Studies on plant diversity are usually based on the total number of species in a community.However,few studies have examined species richness(SR)of different plant life forms in a community along largescale environmen...Studies on plant diversity are usually based on the total number of species in a community.However,few studies have examined species richness(SR)of different plant life forms in a community along largescale environmental gradients.Particularly,the relative importance(RIV)of different plant life forms in a community and how they vary with environmental variables are still unclear.To fill these gaps,we determined plant diversity of ephemeral plants,annual herbs,perennial herbs,and woody plants from 187 sites across drylands in China.The SR patterns of herbaceous plants,especially perennial herbs,and their RIV in plant communities increased with increasing precipitation and soil nutrient content;however,the RIV of annual herbs was not altered along these gradients.The SR and RIV of ephemeral plants were affected mainly by precipitation seasonality.The SR of woody plants had a unimodal relationship with air temperature and exhibited the highest RIV and SR percentage in plant communities under the harshest environments.An obvious shift emerged in plant community composition,SR and their critical impact factors at 238.5 mm of mean annual precipitation(MAP).In mesic regions(>238.5 mm),herbs were the dominant species,and the SR displayed a relatively slow decreasing rate with increasing aridity,which was mediated mainly by MAP and soil nutrients.In arid regions(<238.5 mm),woody plants were the dominant species,and the SR displayed a relatively fast decreasing rate with increasing aridity,which was mediated mainly by climate variables,especially precipitation.Our findings highlight the importance of comparative life form studies in community structure and biodiversity,as their responses to gradients differed substantially on a large scale.展开更多
Memory enables organisms to encode,store,and retrieve information essential for interacting with and adapting to a dynamic environment.As an internal representation of the external world,memory serves as a crucial bri...Memory enables organisms to encode,store,and retrieve information essential for interacting with and adapting to a dynamic environment.As an internal representation of the external world,memory serves as a crucial bridge between past experiences and future behaviors.However,the brain continuously forms new memories,raising the question of how new memories are integrated without disrupting previously formed ones.展开更多
Predictive maintenance plays a crucial role in preventing equipment failures and minimizing operational downtime in modern industries.However,traditional predictive maintenance methods often face challenges in adaptin...Predictive maintenance plays a crucial role in preventing equipment failures and minimizing operational downtime in modern industries.However,traditional predictive maintenance methods often face challenges in adapting to diverse industrial environments and ensuring the transparency and fairness of their predictions.This paper presents a novel predictive maintenance framework that integrates deep learning and optimization techniques while addressing key ethical considerations,such as transparency,fairness,and explainability,in artificial intelligence driven decision-making.The framework employs an Autoencoder for feature reduction,a Convolutional Neural Network for pattern recognition,and a Long Short-Term Memory network for temporal analysis.To enhance transparency,the decision-making process of the framework is made interpretable,allowing stakeholders to understand and trust the model’s predictions.Additionally,Particle Swarm Optimization is used to refine hyperparameters for optimal performance and mitigate potential biases in the model.Experiments are conducted on multiple datasets from different industrial scenarios,with performance validated using accuracy,precision,recall,F1-score,and training time metrics.The results demonstrate an impressive accuracy of up to 99.92%and 99.45%across different datasets,highlighting the framework’s effectiveness in enhancing predictive maintenance strategies.Furthermore,the model’s explainability ensures that the decisions can be audited for fairness and accountability,aligning with ethical standards for critical systems.By addressing transparency and reducing potential biases,this framework contributes to the responsible and trustworthy deployment of artificial intelligence in industrial environments,particularly in safety-critical applications.The results underscore its potential for wide application across various industrial contexts,enhancing both performance and ethical decision-making.展开更多
Objective:To explore the impact of exogenous chitosan on the growth and metabolism of Glycyrrhiza uralensis Fisch.(G.uralensis)and to improve the quality of cultivated G.uralensis for both medicine and food and aid in...Objective:To explore the impact of exogenous chitosan on the growth and metabolism of Glycyrrhiza uralensis Fisch.(G.uralensis)and to improve the quality of cultivated G.uralensis for both medicine and food and aid in the increase in the content of effective components in G.uralensis.Methods:In this study,whole G.uralensis plants were treated with exogenous chitosan,and compre-hensive analyses of secondary metabolites and proteins were conducted using liquid chromatography with tandem mass spectrometry and isobaric tag for relative and absolute quantitation,respectively.Effects of chitosan induction on endogenous hormones of G.uralensis were analyzed using an enzyme-linked immunosorbent assay.Gene ontology function annotation and Kyoto Encyclopedia of Genes and Genomes pathway annotation were conducted to study the effect of chitosan induction on the proteome.Results:Chitosan induction significantly increased the levels of flavonoids in G.uralensis;however,the variation in triterpenoids was not substantial.Biological processes,including photosynthesis,secondary metabolism,and abiotic stress responses,were significantly enriched.Additionally,the photosynthetic pathway,photosynthesis-antenna protein pathway,and plant hormone signal transduction pathway were significantly enriched.In the flavonoid biosynthesis pathway,the upstream-related enzyme phenylalanine ammonia-lyase(PAL)and the downstream-related enzymes chalcone synthase(CHS),polyketide reductase(PKR),chalcone isomerase(CHI),and vestitone reductase(VR)were significantly upregulated.Conclusions:Our findings suggest that chitosan induction may promote the tricarboxylic acid(TCA)cycle,and the TCA cycle enhancement significantly upregulated PAL,CHS,PKR,CHI,and VR,the five key enzymes involved in flavonoid synthesis of G.uralensis,indicating that chitosan induction activated the entire metabolic pathway associated with flavonoids in G.uralensis.Our findings provide a reference for improving the quality of cultivated G.uralensis from the perspective of pharmacodynamic components.展开更多
Migration is a potential strategy to reduce poverty in the Global South.In China,the Poverty-alleviation Relocation(PAR)is a government-led,large-scale migration initiative aimed at eliminating poverty and promoting e...Migration is a potential strategy to reduce poverty in the Global South.In China,the Poverty-alleviation Relocation(PAR)is a government-led,large-scale migration initiative aimed at eliminating poverty and promoting environmental sustainability.To examine the ecological and socio-economic effects of the PAR,we quantified the changes in five types of ecosystem services(ES)as well as the subjective well-being of rural residents in Fuping county,Hebei province of China,by using ES mapping,household survey,and semi-structured interviews.We found that the PAR improves people's quality of life,with the well-being scores associated with transportation,communication,education,and healthcare increasing by 0.45–0.81.Additionally,the PAR enhances the supply of ES,evidenced by the increases in four types of ES in both in-migration and out-migration areas.The ES growth rates in in-migration areas ranged from 0.7%to 3.9%,while in out-migration areas,the rates ranged from 0.4%to 2.5%.However,the changes in income and food well-being are minimal,with scores at 0 and 0.32,respectively.More importantly,the elderly and low-educated residents experience minimal improvements in well-being after relocation.Our findings suggest that for other developing countries seeking to adopt PAR,it is crucial to provide targeted support for livelihood transitions,particularly for marginalized social groups,restore out-migration areas,and strengthen cross-regional cooperation to better address ecological constraints on livelihoods.展开更多
The aim of this work is to find an alternative lubricating grease formulation that can be produced from renewable and biodegradable sources with minimal risks to human health and the environment.We used a castor oil a...The aim of this work is to find an alternative lubricating grease formulation that can be produced from renewable and biodegradable sources with minimal risks to human health and the environment.We used a castor oil and electrospun cellulose acetate propionate(CAp)as raw materials.We hypothesized that the acetyl and propionyl groups could provide an adequate chemical compatibility with the castor oil and that the electrospun nanostructures could enable improved physical stability by creating a variety of morphologies allowing the tailoring of the rheological and tribological properties of the resulting greases.The experimental results show that the use of electrospun CAp nanostructures can indeed yield physically stable formulations,even when used at low concentrations(3 wt%).The resulting dispersions went through structural transitions due to changes in the thickener morphologies and/or concentration,as shown by oscillatory rheology,oil holding capacity,tackiness,and lubrication performance in metal–metal contact.We found that the formulations,containing smooth or porous CAp nanofibers,at 5 wt%as a thickener,possess suitable rheological and tribological properties with a performance comparable to that of traditional lithium lubricating greases.展开更多
A low rare-earth containing ZEK100-O magnesium alloy was welded to AA1230-clad high-strength AA2024-T3 aluminum alloy via solidstate ultrasonic spot welding(USW)to evaluate the microstructure,tensile lap shear strengt...A low rare-earth containing ZEK100-O magnesium alloy was welded to AA1230-clad high-strength AA2024-T3 aluminum alloy via solidstate ultrasonic spot welding(USW)to evaluate the microstructure,tensile lap shear strength,and fatigue properties.The tensile strength increased with increasing welding energy,peaked at a welding energy of 1000 J,and then decreased due to the formation of an increasingly thick diffusion layer mainly containing Al12Mg17intermetallic compound at higher energy levels.The peak tensile lap shear strength attained at 1000 J was attributed to the optimal inter-diffusion between the magnesium alloy and softer AA1230-clad Al layer along with the presence of‘fishhook'-like mechanical interlocks at the weld interface and the formation of an indistinguishable intermetallic layer.The dissimilar joints welded at 1000 J also exhibited a longer fatigue life than other Mg-Al dissimilar joints,suggesting the beneficial role of the softer clad layer with a better intermingling capacity during USW.While the transverse-through-thickness(TTT)failure mode prevailed at lower cyclic loading levels,interfacial failure was the predominant mode of fatigue failure at higher cyclic loads,where distinctive fatigue striations were also observed on the fracture surface of the softer clad Al layer.This was associated with the presence of opening stress and bending moment near the nugget edge despite the tension-tension lap shear cyclic loading applied.展开更多
Healthcare networks are transitioning from manual records to electronic health records,but this shift introduces vulnerabilities such as secure communication issues,privacy concerns,and the presence of malicious nodes...Healthcare networks are transitioning from manual records to electronic health records,but this shift introduces vulnerabilities such as secure communication issues,privacy concerns,and the presence of malicious nodes.Existing machine and deep learning-based anomalies detection methods often rely on centralized training,leading to reduced accuracy and potential privacy breaches.Therefore,this study proposes a Blockchain-based-Federated Learning architecture for Malicious Node Detection(BFL-MND)model.It trains models locally within healthcare clusters,sharing only model updates instead of patient data,preserving privacy and improving accuracy.Cloud and edge computing enhance the model’s scalability,while blockchain ensures secure,tamper-proof access to health data.Using the PhysioNet dataset,the proposed model achieves an accuracy of 0.95,F1 score of 0.93,precision of 0.94,and recall of 0.96,outperforming baseline models like random forest(0.88),adaptive boosting(0.90),logistic regression(0.86),perceptron(0.83),and deep neural networks(0.92).展开更多
Foliar resorption is a principal nutrient conservation mechanism in terrestrial vegetation that could be sensitive to ongoing changes in climate and atmospheric nitrogen(N)deposition.We quantified N resorption in nort...Foliar resorption is a principal nutrient conservation mechanism in terrestrial vegetation that could be sensitive to ongoing changes in climate and atmospheric nitrogen(N)deposition.We quantified N resorption in northern hardwood forests along an elevation gradient of decreasing temperature and increasing soil N availability to evaluate how this critical nutrient cycling process can be expected to respond to global and regional environmental changes.Foliar N resorption proficiency(NRP)increased significantly at lower elevations for both sugar maple and American beech,the dominant species in these forests.Foliar N resorption efficiency(NRE)also decreased with increasing elevation,but only in one year.Both species exhibited strong negative relationships between NRP and soil N availability.Thus,we anticipate that with climate warming and decreasing N inputs,northern hardwood forests can be expected to exhibit stronger N conservation via foliar resorption.Both species also exhibited strong correlations between resorption efficiency of N and C,but resorption of both elements was much greater for beech than sugar maple,suggesting contrasting mechanisms of nutrient conservation between these two widespread species.展开更多
Background Supplementation of choline chloride in culture medium programs the preimplantation bovine embryo to increase weaning weight of the resultant calf.Here,it was hypothesized that similar programming actions of...Background Supplementation of choline chloride in culture medium programs the preimplantation bovine embryo to increase weaning weight of the resultant calf.Here,it was hypothesized that similar programming actions of choline can be induced by feeding rumen-protected choline(RPC)to beef cows during the periconceptional period.Results A preliminary experiment was conducted to determine changes in circulating concentrations of choline and its metabolites after RPC supplementation.Suckled beef cows were individually fed 0,30,60,and 90 g of RPC(i.e.,0,8.6,17.3 and 25.9 g choline chloride)and blood samples were collected at random times after feeding.There were no differences in plasma concentrations of choline or its metabolites between groups.In the second experiment,effects of feeding 60 g/d RPC from d-1 to 7 relative to timed artificial insemination were examined for suckled beef cows.Feeding RPC did not affect pregnancy or calving rates,pregnancy losses,plasma concentrations of pregnancy-associated glycoproteins,gestation length or calf birth weight.Calves from RPC fed dams were lighter than control calves at~118 days of age(range 75–150;age included in the statistical model)and at weaning at~248 days of age.There was no effect of treatment on hip height at~118 days of age although there was a trend for RPC calves to be shorter at weaning.Weight/height ratio was lower for RPC than control at both 118 and 248 days of age.Treatment did not affect testis weight at~118 days of age.Conclusions Supplementation of RPC during the periconceptional period programmed development to alter calf phenotype in the postnatal period.The net result,reduced body weight,was the opposite of the phenotype caused by the addition of choline to embryo culture medium.展开更多
When the dominant species in a plant community are palatable,many believe that large herbivores will reduce the dominant species and promote the proportion of previously suppressed species.However,this view may not al...When the dominant species in a plant community are palatable,many believe that large herbivores will reduce the dominant species and promote the proportion of previously suppressed species.However,this view may not always hold true.We conducted a 4-year yak grazing experiment on the Qinghai-Tibet Plateau and tracked the plant compositions of the rotational grazing(RG)and grazing exclusion(GE)grasslands during the four years.The results showed that in the absence of yaks under GE,the plant community was dominated by two palatable species,Kobresia pygmaea and Stipa capillata,due to their small leaf area and rapid growth strategy.The presence of yaks under RG significantly inhibited S.capillata and over half of the forbs,while the proportion of K.pygmaea increased and it became the absolute dominant species,contradicting the view that large herbivores inhibit palatable species.Interannually,the dominance of K.pygmaea under RG decreased in the dry year,leading to an increase in the dominance of the other eight species.Under GE,the dominance of K.pygmaea declined notably in the dry year,while S.capillata and seven other forbs increased substantially.Overall,these results suggest that K.pygmaea is grazing-tolerant but not drought-tolerant,whereas the other eight species are drought-tolerant but not grazingtolerant.At the community level,community composition shifts resulting from succession after grazing exclusion exceeded those caused by drought,drought tends to induce community species turnover while grazing tends to induce species abundance variations.In summary,our conclusions remind ranch managers that when considering the impact of livestock on plant community composition,they should factor in local conditions and climate change rather than simply assuming that livestock will suppress the palatable species.展开更多
Background The biological mechanisms by which postdiagnosis physical activity improves disease-free survival in colorectal cancer survivors remain incompletely understood.This trial tested the hypothesis that 12 weeks...Background The biological mechanisms by which postdiagnosis physical activity improves disease-free survival in colorectal cancer survivors remain incompletely understood.This trial tested the hypothesis that 12 weeks of moderate-intensity aerobic exercise,when compared with a control group,would change inflammation,circulating tumor cells(CTCs),and circulating tumor DNA(ctDNA)in a manner consistent with an improved cancer prognosis.Methods This trial randomized Stages I–III colorectal cancer survivors to 12 weeks of home-based moderate-intensity aerobic exercise or a waitlist control group.The co-primary endpoints were high-sensitivity C-reactive protein(hs-CRP)and interleukin-6(IL-6),secondary endpoints were soluble tumor necrosis factor-αreceptor 2(sTNFαR2)and CTCs,and the exploratory endpoint was tumor fraction quantified from ctDNA.Results Sixty subjects were randomized(age=60.6±10.8 years,mean±SD;39(65%)females;46(77%)colonic primary tumor),and 59(98%)subjects completed the study.Over 12 weeks,exercise adherence was 92%(95%confidence interval(95%CI):86‒99).Exercise improved submaximal fitness capacity(0.36 metabolic equivalents;95%CI:0.05‒0.67;p=0.025)and objectively measured moderate-to-vigorous-intensity physical activity(34.8%,95%CI:11.3‒63.1;p=0.002)compared to control.Exercise did not change hs-CRP(20.9%,95%CI:−17.1 to 76.2;p=0.32),IL-6(11.4%,95%CI:−7.5 to 34.0;p=0.25),or sTNFαR2(−3.6%,95%CI:−13.7 to 7.7;p=0.52)compared to control.In the subgroup of subjects with elevated baseline hs-CRP(n=35,58.3%),aerobic exercise reduced hs-CRP(−35.5%,95%CI:−55.3 to−3.8;p=0.031).Exercise did not change CTCs(0.59 cells/mL,95%CI:−0.33 to 1.51;p=0.21)or tumor fraction(0.0005,95%CI:−0.0024 to 0.0034;p=0.73).In exploratory analyses,higher aerobic exercise adherence correlated with a reduction in CTCs(ρ=−0.37,95%CI:−0.66 to−0.08;p=0.013).Conclusion Colorectal cancer survivors achieved high adherence to a home-based moderate-intensity aerobic exercise prescription that improved fitness capacity and physical activity but did not reduce inflammation or change tumor endpoints from a liquid biopsy.展开更多
A wearable health monitoring system is a promising device for opening the era of the fourth industrial revolution due to increasing interest in health among modern people.Wearable health monitoring systems were demons...A wearable health monitoring system is a promising device for opening the era of the fourth industrial revolution due to increasing interest in health among modern people.Wearable health monitoring systems were demonstrated by several researchers,but still have critical issues of low performance,inefficient and complex fabrication processes.Here,we present the world’s first wearable multifunctional health monitoring system based on flash-induced porous graphene(FPG).FPG was efficiently synthesized via flash lamp,resulting in a large area in four milliseconds.Moreover,to demonstrate the sensing performance of FPG,a wearable multifunctional health monitoring system was fabricated onto a single substrate.A carbon nanotube-polydimethylsiloxane(CNT-PDMS)nanocomposite electrode was successfully formed on the uneven FPG surface using screen printing.The performance of the FPG-based wearable multifunctional health monitoring system was enhanced by the large surface area of the 3D-porous structure FPG.Finally,the FPG-based wearable multifunctional health monitoring system effectively detected motion,skin temperature,and sweat with a strain GF of 2564.38,a linear thermal response of 0.98Ω℃^(-1) under the skin temperature range,and a low ion detection limit of 10μM.展开更多
移动增强现实应用中,用户频繁地与环境中不同的智能物体交互完成任务,其完成效率和用户体验由所采用的定向交互技术决定.然而,从交互手段上来说,现阶段定向交互依赖于Wi-Fi、BLE等无线技术,其信号全向传播的特点使其不能利用用户的空间...移动增强现实应用中,用户频繁地与环境中不同的智能物体交互完成任务,其完成效率和用户体验由所采用的定向交互技术决定.然而,从交互手段上来说,现阶段定向交互依赖于Wi-Fi、BLE等无线技术,其信号全向传播的特点使其不能利用用户的空间环境(即位置和方向)来缩短互动时间,带来了不必要的时间成本;从交互界面上来说,现阶段基于视觉的界面存在可靠性低、扩展性低等问题,进一步限制了系统的通用性.本文介绍了RetroAR——基于可见光逆反射通信的定向交互系统.RetroAR利用了光的定向传播特性来保留用户的空间环境,并依靠逆反射通信实现用户与目标设备之间无连接的快速定向交互.系统实验表明,RetroAR最远可在4 m距离支持100°视角的交互,同时实现厘米级的六自由度(6-Degrees Of Freedom,6-DoF)三维跟踪.用户研究表明,与基于Wi-Fi的解决方案相比,RetroAR将非接触式控制的交互时间减少了2倍,并且具有更好的用户体验.RetroAR借助可见光逆反射通信来利用用户空间环境,保持交互过程中的直观性.用户可以“所指即所控”的方式与多个目标进行互动,实现类似自然交互的快速定向交互.展开更多
基金supported by the National Key Research and Development Program of China(2023YFF0805602)National Natural Science Foundation of China(32225032,32001192,32271597)+1 种基金the Innovation Base Project of Gansu Province(2021YFF0703904)the Science and Technology Program of Gansu Province(24JRRA515,22JR5RA525,23JRRA1157).
文摘Studies on plant diversity are usually based on the total number of species in a community.However,few studies have examined species richness(SR)of different plant life forms in a community along largescale environmental gradients.Particularly,the relative importance(RIV)of different plant life forms in a community and how they vary with environmental variables are still unclear.To fill these gaps,we determined plant diversity of ephemeral plants,annual herbs,perennial herbs,and woody plants from 187 sites across drylands in China.The SR patterns of herbaceous plants,especially perennial herbs,and their RIV in plant communities increased with increasing precipitation and soil nutrient content;however,the RIV of annual herbs was not altered along these gradients.The SR and RIV of ephemeral plants were affected mainly by precipitation seasonality.The SR of woody plants had a unimodal relationship with air temperature and exhibited the highest RIV and SR percentage in plant communities under the harshest environments.An obvious shift emerged in plant community composition,SR and their critical impact factors at 238.5 mm of mean annual precipitation(MAP).In mesic regions(>238.5 mm),herbs were the dominant species,and the SR displayed a relatively slow decreasing rate with increasing aridity,which was mediated mainly by MAP and soil nutrients.In arid regions(<238.5 mm),woody plants were the dominant species,and the SR displayed a relatively fast decreasing rate with increasing aridity,which was mediated mainly by climate variables,especially precipitation.Our findings highlight the importance of comparative life form studies in community structure and biodiversity,as their responses to gradients differed substantially on a large scale.
文摘Memory enables organisms to encode,store,and retrieve information essential for interacting with and adapting to a dynamic environment.As an internal representation of the external world,memory serves as a crucial bridge between past experiences and future behaviors.However,the brain continuously forms new memories,raising the question of how new memories are integrated without disrupting previously formed ones.
文摘Predictive maintenance plays a crucial role in preventing equipment failures and minimizing operational downtime in modern industries.However,traditional predictive maintenance methods often face challenges in adapting to diverse industrial environments and ensuring the transparency and fairness of their predictions.This paper presents a novel predictive maintenance framework that integrates deep learning and optimization techniques while addressing key ethical considerations,such as transparency,fairness,and explainability,in artificial intelligence driven decision-making.The framework employs an Autoencoder for feature reduction,a Convolutional Neural Network for pattern recognition,and a Long Short-Term Memory network for temporal analysis.To enhance transparency,the decision-making process of the framework is made interpretable,allowing stakeholders to understand and trust the model’s predictions.Additionally,Particle Swarm Optimization is used to refine hyperparameters for optimal performance and mitigate potential biases in the model.Experiments are conducted on multiple datasets from different industrial scenarios,with performance validated using accuracy,precision,recall,F1-score,and training time metrics.The results demonstrate an impressive accuracy of up to 99.92%and 99.45%across different datasets,highlighting the framework’s effectiveness in enhancing predictive maintenance strategies.Furthermore,the model’s explainability ensures that the decisions can be audited for fairness and accountability,aligning with ethical standards for critical systems.By addressing transparency and reducing potential biases,this framework contributes to the responsible and trustworthy deployment of artificial intelligence in industrial environments,particularly in safety-critical applications.The results underscore its potential for wide application across various industrial contexts,enhancing both performance and ethical decision-making.
基金supported by grants from the National Natural Science Foundation of China(81773838).
文摘Objective:To explore the impact of exogenous chitosan on the growth and metabolism of Glycyrrhiza uralensis Fisch.(G.uralensis)and to improve the quality of cultivated G.uralensis for both medicine and food and aid in the increase in the content of effective components in G.uralensis.Methods:In this study,whole G.uralensis plants were treated with exogenous chitosan,and compre-hensive analyses of secondary metabolites and proteins were conducted using liquid chromatography with tandem mass spectrometry and isobaric tag for relative and absolute quantitation,respectively.Effects of chitosan induction on endogenous hormones of G.uralensis were analyzed using an enzyme-linked immunosorbent assay.Gene ontology function annotation and Kyoto Encyclopedia of Genes and Genomes pathway annotation were conducted to study the effect of chitosan induction on the proteome.Results:Chitosan induction significantly increased the levels of flavonoids in G.uralensis;however,the variation in triterpenoids was not substantial.Biological processes,including photosynthesis,secondary metabolism,and abiotic stress responses,were significantly enriched.Additionally,the photosynthetic pathway,photosynthesis-antenna protein pathway,and plant hormone signal transduction pathway were significantly enriched.In the flavonoid biosynthesis pathway,the upstream-related enzyme phenylalanine ammonia-lyase(PAL)and the downstream-related enzymes chalcone synthase(CHS),polyketide reductase(PKR),chalcone isomerase(CHI),and vestitone reductase(VR)were significantly upregulated.Conclusions:Our findings suggest that chitosan induction may promote the tricarboxylic acid(TCA)cycle,and the TCA cycle enhancement significantly upregulated PAL,CHS,PKR,CHI,and VR,the five key enzymes involved in flavonoid synthesis of G.uralensis,indicating that chitosan induction activated the entire metabolic pathway associated with flavonoids in G.uralensis.Our findings provide a reference for improving the quality of cultivated G.uralensis from the perspective of pharmacodynamic components.
基金National Natural Science Foundation of China,No.42361144859Team Construction Project of Faculty of Geographical Science,BNU,No.2024-JXTD-03,No.2024-KYTD-09The Beijing Normal University Tang Scholar,No.2021。
文摘Migration is a potential strategy to reduce poverty in the Global South.In China,the Poverty-alleviation Relocation(PAR)is a government-led,large-scale migration initiative aimed at eliminating poverty and promoting environmental sustainability.To examine the ecological and socio-economic effects of the PAR,we quantified the changes in five types of ecosystem services(ES)as well as the subjective well-being of rural residents in Fuping county,Hebei province of China,by using ES mapping,household survey,and semi-structured interviews.We found that the PAR improves people's quality of life,with the well-being scores associated with transportation,communication,education,and healthcare increasing by 0.45–0.81.Additionally,the PAR enhances the supply of ES,evidenced by the increases in four types of ES in both in-migration and out-migration areas.The ES growth rates in in-migration areas ranged from 0.7%to 3.9%,while in out-migration areas,the rates ranged from 0.4%to 2.5%.However,the changes in income and food well-being are minimal,with scores at 0 and 0.32,respectively.More importantly,the elderly and low-educated residents experience minimal improvements in well-being after relocation.Our findings suggest that for other developing countries seeking to adopt PAR,it is crucial to provide targeted support for livelihood transitions,particularly for marginalized social groups,restore out-migration areas,and strengthen cross-regional cooperation to better address ecological constraints on livelihoods.
基金sponsored by MCIN/AEI/10.13039/501100011033“ERDF A way of making Europe”(grant PID2021-125637OB-I00)FEDER/Junta de Andalucía Programmes(grants PY20_00751 and UHU202029).
文摘The aim of this work is to find an alternative lubricating grease formulation that can be produced from renewable and biodegradable sources with minimal risks to human health and the environment.We used a castor oil and electrospun cellulose acetate propionate(CAp)as raw materials.We hypothesized that the acetyl and propionyl groups could provide an adequate chemical compatibility with the castor oil and that the electrospun nanostructures could enable improved physical stability by creating a variety of morphologies allowing the tailoring of the rheological and tribological properties of the resulting greases.The experimental results show that the use of electrospun CAp nanostructures can indeed yield physically stable formulations,even when used at low concentrations(3 wt%).The resulting dispersions went through structural transitions due to changes in the thickener morphologies and/or concentration,as shown by oscillatory rheology,oil holding capacity,tackiness,and lubrication performance in metal–metal contact.We found that the formulations,containing smooth or porous CAp nanofibers,at 5 wt%as a thickener,possess suitable rheological and tribological properties with a performance comparable to that of traditional lithium lubricating greases.
基金the National Natural Science Foundation of China(Grant No.51971183)supported by OU(Osaka University,Japan)program for multilateral international collaboration research in joining and welding。
文摘A low rare-earth containing ZEK100-O magnesium alloy was welded to AA1230-clad high-strength AA2024-T3 aluminum alloy via solidstate ultrasonic spot welding(USW)to evaluate the microstructure,tensile lap shear strength,and fatigue properties.The tensile strength increased with increasing welding energy,peaked at a welding energy of 1000 J,and then decreased due to the formation of an increasingly thick diffusion layer mainly containing Al12Mg17intermetallic compound at higher energy levels.The peak tensile lap shear strength attained at 1000 J was attributed to the optimal inter-diffusion between the magnesium alloy and softer AA1230-clad Al layer along with the presence of‘fishhook'-like mechanical interlocks at the weld interface and the formation of an indistinguishable intermetallic layer.The dissimilar joints welded at 1000 J also exhibited a longer fatigue life than other Mg-Al dissimilar joints,suggesting the beneficial role of the softer clad layer with a better intermingling capacity during USW.While the transverse-through-thickness(TTT)failure mode prevailed at lower cyclic loading levels,interfacial failure was the predominant mode of fatigue failure at higher cyclic loads,where distinctive fatigue striations were also observed on the fracture surface of the softer clad Al layer.This was associated with the presence of opening stress and bending moment near the nugget edge despite the tension-tension lap shear cyclic loading applied.
基金funded by the Northern Border University,Arar,KSA,under the project number“NBU-FFR-2025-3555-07”.
文摘Healthcare networks are transitioning from manual records to electronic health records,but this shift introduces vulnerabilities such as secure communication issues,privacy concerns,and the presence of malicious nodes.Existing machine and deep learning-based anomalies detection methods often rely on centralized training,leading to reduced accuracy and potential privacy breaches.Therefore,this study proposes a Blockchain-based-Federated Learning architecture for Malicious Node Detection(BFL-MND)model.It trains models locally within healthcare clusters,sharing only model updates instead of patient data,preserving privacy and improving accuracy.Cloud and edge computing enhance the model’s scalability,while blockchain ensures secure,tamper-proof access to health data.Using the PhysioNet dataset,the proposed model achieves an accuracy of 0.95,F1 score of 0.93,precision of 0.94,and recall of 0.96,outperforming baseline models like random forest(0.88),adaptive boosting(0.90),logistic regression(0.86),perceptron(0.83),and deep neural networks(0.92).
基金National Science Foundation supported this research through the Long Term Ecological Research(LTER)Grant to Hubbard Brook(NSF DEB1114804,1637685,and 2224545)by the project grant(NSF DEB,2020397).
文摘Foliar resorption is a principal nutrient conservation mechanism in terrestrial vegetation that could be sensitive to ongoing changes in climate and atmospheric nitrogen(N)deposition.We quantified N resorption in northern hardwood forests along an elevation gradient of decreasing temperature and increasing soil N availability to evaluate how this critical nutrient cycling process can be expected to respond to global and regional environmental changes.Foliar N resorption proficiency(NRP)increased significantly at lower elevations for both sugar maple and American beech,the dominant species in these forests.Foliar N resorption efficiency(NRE)also decreased with increasing elevation,but only in one year.Both species exhibited strong negative relationships between NRP and soil N availability.Thus,we anticipate that with climate warming and decreasing N inputs,northern hardwood forests can be expected to exhibit stronger N conservation via foliar resorption.Both species also exhibited strong correlations between resorption efficiency of N and C,but resorption of both elements was much greater for beech than sugar maple,suggesting contrasting mechanisms of nutrient conservation between these two widespread species.
基金supported by the L.E.“Red”Larson Endowment and grants number 2020-67015-30821 and 2023-67015-40730 from the Agriculture and Food Research Initiative of USDA-NIFAsupported by the Higher Education Commission of Pakistan。
文摘Background Supplementation of choline chloride in culture medium programs the preimplantation bovine embryo to increase weaning weight of the resultant calf.Here,it was hypothesized that similar programming actions of choline can be induced by feeding rumen-protected choline(RPC)to beef cows during the periconceptional period.Results A preliminary experiment was conducted to determine changes in circulating concentrations of choline and its metabolites after RPC supplementation.Suckled beef cows were individually fed 0,30,60,and 90 g of RPC(i.e.,0,8.6,17.3 and 25.9 g choline chloride)and blood samples were collected at random times after feeding.There were no differences in plasma concentrations of choline or its metabolites between groups.In the second experiment,effects of feeding 60 g/d RPC from d-1 to 7 relative to timed artificial insemination were examined for suckled beef cows.Feeding RPC did not affect pregnancy or calving rates,pregnancy losses,plasma concentrations of pregnancy-associated glycoproteins,gestation length or calf birth weight.Calves from RPC fed dams were lighter than control calves at~118 days of age(range 75–150;age included in the statistical model)and at weaning at~248 days of age.There was no effect of treatment on hip height at~118 days of age although there was a trend for RPC calves to be shorter at weaning.Weight/height ratio was lower for RPC than control at both 118 and 248 days of age.Treatment did not affect testis weight at~118 days of age.Conclusions Supplementation of RPC during the periconceptional period programmed development to alter calf phenotype in the postnatal period.The net result,reduced body weight,was the opposite of the phenotype caused by the addition of choline to embryo culture medium.
基金financially supported by grants from the National Natural Science Foundation of China(32101315 and 32101326)the National Key R&D Program of China(2021YFE0112400)+2 种基金the Second Tibetan Plateau Scientific Expedition and Research Program,China(2019QZKK0307)the HighLevel Talent Research Start-Up Project of Chongqing Technology and Business University,China(950319097)the Scientific and Technological Research Program of Chongqing Municipal Education Commission,China(KJQN202100827)。
文摘When the dominant species in a plant community are palatable,many believe that large herbivores will reduce the dominant species and promote the proportion of previously suppressed species.However,this view may not always hold true.We conducted a 4-year yak grazing experiment on the Qinghai-Tibet Plateau and tracked the plant compositions of the rotational grazing(RG)and grazing exclusion(GE)grasslands during the four years.The results showed that in the absence of yaks under GE,the plant community was dominated by two palatable species,Kobresia pygmaea and Stipa capillata,due to their small leaf area and rapid growth strategy.The presence of yaks under RG significantly inhibited S.capillata and over half of the forbs,while the proportion of K.pygmaea increased and it became the absolute dominant species,contradicting the view that large herbivores inhibit palatable species.Interannually,the dominance of K.pygmaea under RG decreased in the dry year,leading to an increase in the dominance of the other eight species.Under GE,the dominance of K.pygmaea declined notably in the dry year,while S.capillata and seven other forbs increased substantially.Overall,these results suggest that K.pygmaea is grazing-tolerant but not drought-tolerant,whereas the other eight species are drought-tolerant but not grazingtolerant.At the community level,community composition shifts resulting from succession after grazing exclusion exceeded those caused by drought,drought tends to induce community species turnover while grazing tends to induce species abundance variations.In summary,our conclusions remind ranch managers that when considering the impact of livestock on plant community composition,they should factor in local conditions and climate change rather than simply assuming that livestock will suppress the palatable species.
基金supported by the National Cancer Institute of the National Institutes of Health under Award Number R00CA218603
文摘Background The biological mechanisms by which postdiagnosis physical activity improves disease-free survival in colorectal cancer survivors remain incompletely understood.This trial tested the hypothesis that 12 weeks of moderate-intensity aerobic exercise,when compared with a control group,would change inflammation,circulating tumor cells(CTCs),and circulating tumor DNA(ctDNA)in a manner consistent with an improved cancer prognosis.Methods This trial randomized Stages I–III colorectal cancer survivors to 12 weeks of home-based moderate-intensity aerobic exercise or a waitlist control group.The co-primary endpoints were high-sensitivity C-reactive protein(hs-CRP)and interleukin-6(IL-6),secondary endpoints were soluble tumor necrosis factor-αreceptor 2(sTNFαR2)and CTCs,and the exploratory endpoint was tumor fraction quantified from ctDNA.Results Sixty subjects were randomized(age=60.6±10.8 years,mean±SD;39(65%)females;46(77%)colonic primary tumor),and 59(98%)subjects completed the study.Over 12 weeks,exercise adherence was 92%(95%confidence interval(95%CI):86‒99).Exercise improved submaximal fitness capacity(0.36 metabolic equivalents;95%CI:0.05‒0.67;p=0.025)and objectively measured moderate-to-vigorous-intensity physical activity(34.8%,95%CI:11.3‒63.1;p=0.002)compared to control.Exercise did not change hs-CRP(20.9%,95%CI:−17.1 to 76.2;p=0.32),IL-6(11.4%,95%CI:−7.5 to 34.0;p=0.25),or sTNFαR2(−3.6%,95%CI:−13.7 to 7.7;p=0.52)compared to control.In the subgroup of subjects with elevated baseline hs-CRP(n=35,58.3%),aerobic exercise reduced hs-CRP(−35.5%,95%CI:−55.3 to−3.8;p=0.031).Exercise did not change CTCs(0.59 cells/mL,95%CI:−0.33 to 1.51;p=0.21)or tumor fraction(0.0005,95%CI:−0.0024 to 0.0034;p=0.73).In exploratory analyses,higher aerobic exercise adherence correlated with a reduction in CTCs(ρ=−0.37,95%CI:−0.66 to−0.08;p=0.013).Conclusion Colorectal cancer survivors achieved high adherence to a home-based moderate-intensity aerobic exercise prescription that improved fitness capacity and physical activity but did not reduce inflammation or change tumor endpoints from a liquid biopsy.
基金supported by the National Research Foundation of Korea(NRF)grants funded by the Ministry of Science,ICT and Future Planning(MSIT)(RS-2024-00408989,RS-2023-00278906,and RS-2023-00217661)the Center for Universitywide Research Facilities(CURF)at Jeonbuk National University for High-Resolution In Vivo Micro-Computed Tomography(Skyscan 1276,BRUKER).
文摘A wearable health monitoring system is a promising device for opening the era of the fourth industrial revolution due to increasing interest in health among modern people.Wearable health monitoring systems were demonstrated by several researchers,but still have critical issues of low performance,inefficient and complex fabrication processes.Here,we present the world’s first wearable multifunctional health monitoring system based on flash-induced porous graphene(FPG).FPG was efficiently synthesized via flash lamp,resulting in a large area in four milliseconds.Moreover,to demonstrate the sensing performance of FPG,a wearable multifunctional health monitoring system was fabricated onto a single substrate.A carbon nanotube-polydimethylsiloxane(CNT-PDMS)nanocomposite electrode was successfully formed on the uneven FPG surface using screen printing.The performance of the FPG-based wearable multifunctional health monitoring system was enhanced by the large surface area of the 3D-porous structure FPG.Finally,the FPG-based wearable multifunctional health monitoring system effectively detected motion,skin temperature,and sweat with a strain GF of 2564.38,a linear thermal response of 0.98Ω℃^(-1) under the skin temperature range,and a low ion detection limit of 10μM.
文摘移动增强现实应用中,用户频繁地与环境中不同的智能物体交互完成任务,其完成效率和用户体验由所采用的定向交互技术决定.然而,从交互手段上来说,现阶段定向交互依赖于Wi-Fi、BLE等无线技术,其信号全向传播的特点使其不能利用用户的空间环境(即位置和方向)来缩短互动时间,带来了不必要的时间成本;从交互界面上来说,现阶段基于视觉的界面存在可靠性低、扩展性低等问题,进一步限制了系统的通用性.本文介绍了RetroAR——基于可见光逆反射通信的定向交互系统.RetroAR利用了光的定向传播特性来保留用户的空间环境,并依靠逆反射通信实现用户与目标设备之间无连接的快速定向交互.系统实验表明,RetroAR最远可在4 m距离支持100°视角的交互,同时实现厘米级的六自由度(6-Degrees Of Freedom,6-DoF)三维跟踪.用户研究表明,与基于Wi-Fi的解决方案相比,RetroAR将非接触式控制的交互时间减少了2倍,并且具有更好的用户体验.RetroAR借助可见光逆反射通信来利用用户空间环境,保持交互过程中的直观性.用户可以“所指即所控”的方式与多个目标进行互动,实现类似自然交互的快速定向交互.
