Background: HPV is one of the main sexually transmitted diseases, especially among the female population. This is an important etiologic agent for the development of cervical intraepithelial lesions and cervical cance...Background: HPV is one of the main sexually transmitted diseases, especially among the female population. This is an important etiologic agent for the development of cervical intraepithelial lesions and cervical cancer. It is considered a public health problem, since young women are the most vulnerable group to this virus. Therefore, it is important that the socioeconomic and demographic profile of these women and their risk behaviors are known, so that it is possible to contribute in reducing infection occurrences in the studied population. Objectives: To describe the socioeconomic and demographic characteristics and investigate the behavioral sexual-affective aspects of risk of adolescents and young students from Rio de Janeiro/Brazil when tackling HPV infection. Methods: A group composed by 128 individuals susceptible to HPV—classified as adolescent women and young women who are students at a high school in one unity of the municipality of Rio de Janeiro. The studied period was from May to November. A quantitative descriptive approach was used, in which data were highlighted in variables, divided into economic, demographic and behavioral characteristics. Data were entered into an Excel spreadsheet and organized by descriptive statistics performed by simple frequency (%). Results: The age range of the young women who have the possibility of being infected with HPV was from 15 to 25. The focused family income among these young women was up to 2 minimum wages. The risk behavior detected in 37.5% of adolescent women and in 43.8% of young women is that these women never used condoms in sexual intercourse. Conclusion: The research showed that the studied women are vulnerable due to risk behavior practices that may lead to the virus acquisition. More focuses on educational actions of preventive measures regarding HPV infection should be emphasized, favoring a lower incidence of human papillomavirus infection and cervical cancer.展开更多
Background: Hepatocellular adenoma is a rare liver tumor that may require surgical treatment in cases of hemorrhage or suspicion of malignant lesions. Aim: To analyze data from patients who underwent hepatectomy for h...Background: Hepatocellular adenoma is a rare liver tumor that may require surgical treatment in cases of hemorrhage or suspicion of malignant lesions. Aim: To analyze data from patients who underwent hepatectomy for hepatocellular adenoma (HCA) in Rio de Janeiro, Brazil. Methods: From January 2005 to March 2019, sixty-nine patients with HCA underwent hepatectomy at centers in Rio de Janeiro. They were included in the analysis patients undergoing hepatectomy with pathological diagnosis of hepatocellular adenoma and excluded patients with hepatectomy with anatomopathological diagnosis other than hepatocellular adenoma, mainly nodular focal hyperplasia. Data related to patients, tumor and surgery were analyzed retrospectively. Results: Sixty patients (87%) were female and nine were male. Among women, 83% had a history of contraceptive use;among men, only one had an androgen intake history. Overall mean age was 36.4 years (15 - 49), with men older than women (33.9 ± 8.14 years vs. 40.4 ± 6.27 years;P = 0.02). Forty one patients reported abdominal pain, associated or not to other symptoms;32% had an episode of hemorrhage;28 were asymptomatic with an incidental radiological finding. In total, 45 patients presented only one lesion and overall mean size was 8.1 cm (2 - 31);tumors were larger among men (mean size 12.9 ± 9.86 cm vs. 7.7 ± 4.58 cm;P = 0.009). Twenty one surgeries were laparoscopic. Hepatocellular carcinoma (HCC) was identified in three specimens and the incidence was higher among men (22.2% vs. 1.6%;P = 0.042) and in tumors larger than 20 cm (66.6% vs. 0.02%). There was no perioperative mortality. Two of the three patients with HCC died with extrahepatic recurrence;the remaining patient is well after 36 months. Overall mean follow-up time was 14.2 months (2 - 76). Conclusion: Male patients with HCA were older and had larger tumors when compared to females. Incidence of HCC was higher among men and in lesions larger than 20 cm. Male patients with HCA should be treated more aggressively than females.展开更多
Examples of photoluminescence(PL)are being reported with increasing frequency in a wide range of organisms from diverse ecosystems.However,the chemical basis of this PL remains poorly defined,and our understanding of i...Examples of photoluminescence(PL)are being reported with increasing frequency in a wide range of organisms from diverse ecosystems.However,the chemical basis of this PL remains poorly defined,and our understanding of its potential ecological function is still superficial.Among mammals,recent analyses have identified free-base por-phyrins as the compounds responsible for the reddish ultraviolet-induced photoluminescence(UV-PL)observed in the pelage of springhares and hedgehogs.However,the localization of the pigments within the hair largely remains to be determined.Here,we use photoluminescence multispectral imaging emission and excitation spec-troscopy to detect,map,and characterize porphyrinic compounds in skin appendages in situ.We also document new cases of mammalian UV-PL caused by free-base porphyrins in distantly related species.Spatial distribution of the UV-PL is strongly suggestive of an endogenous origin of the porphyrinic compounds.We argue that reddish UV-PL is predominantly observed in crepuscular and nocturnal mammals because porphyrins are photodegradable.Con-sequently,this phenomenon may not have a specific function in intra-or interspecific communication but rather represents a byproduct of potentially widespread physiological processes.展开更多
文摘Background: HPV is one of the main sexually transmitted diseases, especially among the female population. This is an important etiologic agent for the development of cervical intraepithelial lesions and cervical cancer. It is considered a public health problem, since young women are the most vulnerable group to this virus. Therefore, it is important that the socioeconomic and demographic profile of these women and their risk behaviors are known, so that it is possible to contribute in reducing infection occurrences in the studied population. Objectives: To describe the socioeconomic and demographic characteristics and investigate the behavioral sexual-affective aspects of risk of adolescents and young students from Rio de Janeiro/Brazil when tackling HPV infection. Methods: A group composed by 128 individuals susceptible to HPV—classified as adolescent women and young women who are students at a high school in one unity of the municipality of Rio de Janeiro. The studied period was from May to November. A quantitative descriptive approach was used, in which data were highlighted in variables, divided into economic, demographic and behavioral characteristics. Data were entered into an Excel spreadsheet and organized by descriptive statistics performed by simple frequency (%). Results: The age range of the young women who have the possibility of being infected with HPV was from 15 to 25. The focused family income among these young women was up to 2 minimum wages. The risk behavior detected in 37.5% of adolescent women and in 43.8% of young women is that these women never used condoms in sexual intercourse. Conclusion: The research showed that the studied women are vulnerable due to risk behavior practices that may lead to the virus acquisition. More focuses on educational actions of preventive measures regarding HPV infection should be emphasized, favoring a lower incidence of human papillomavirus infection and cervical cancer.
文摘Background: Hepatocellular adenoma is a rare liver tumor that may require surgical treatment in cases of hemorrhage or suspicion of malignant lesions. Aim: To analyze data from patients who underwent hepatectomy for hepatocellular adenoma (HCA) in Rio de Janeiro, Brazil. Methods: From January 2005 to March 2019, sixty-nine patients with HCA underwent hepatectomy at centers in Rio de Janeiro. They were included in the analysis patients undergoing hepatectomy with pathological diagnosis of hepatocellular adenoma and excluded patients with hepatectomy with anatomopathological diagnosis other than hepatocellular adenoma, mainly nodular focal hyperplasia. Data related to patients, tumor and surgery were analyzed retrospectively. Results: Sixty patients (87%) were female and nine were male. Among women, 83% had a history of contraceptive use;among men, only one had an androgen intake history. Overall mean age was 36.4 years (15 - 49), with men older than women (33.9 ± 8.14 years vs. 40.4 ± 6.27 years;P = 0.02). Forty one patients reported abdominal pain, associated or not to other symptoms;32% had an episode of hemorrhage;28 were asymptomatic with an incidental radiological finding. In total, 45 patients presented only one lesion and overall mean size was 8.1 cm (2 - 31);tumors were larger among men (mean size 12.9 ± 9.86 cm vs. 7.7 ± 4.58 cm;P = 0.009). Twenty one surgeries were laparoscopic. Hepatocellular carcinoma (HCC) was identified in three specimens and the incidence was higher among men (22.2% vs. 1.6%;P = 0.042) and in tumors larger than 20 cm (66.6% vs. 0.02%). There was no perioperative mortality. Two of the three patients with HCC died with extrahepatic recurrence;the remaining patient is well after 36 months. Overall mean follow-up time was 14.2 months (2 - 76). Conclusion: Male patients with HCA were older and had larger tumors when compared to females. Incidence of HCC was higher among men and in lesions larger than 20 cm. Male patients with HCA should be treated more aggressively than females.
基金supported by the Elsa-Neumann-Stipendium(Humboldt-Universität zu Berlin)supported by the Fyssen Foundation and the Alexander Von Humboldt Foundation.
文摘Examples of photoluminescence(PL)are being reported with increasing frequency in a wide range of organisms from diverse ecosystems.However,the chemical basis of this PL remains poorly defined,and our understanding of its potential ecological function is still superficial.Among mammals,recent analyses have identified free-base por-phyrins as the compounds responsible for the reddish ultraviolet-induced photoluminescence(UV-PL)observed in the pelage of springhares and hedgehogs.However,the localization of the pigments within the hair largely remains to be determined.Here,we use photoluminescence multispectral imaging emission and excitation spec-troscopy to detect,map,and characterize porphyrinic compounds in skin appendages in situ.We also document new cases of mammalian UV-PL caused by free-base porphyrins in distantly related species.Spatial distribution of the UV-PL is strongly suggestive of an endogenous origin of the porphyrinic compounds.We argue that reddish UV-PL is predominantly observed in crepuscular and nocturnal mammals because porphyrins are photodegradable.Con-sequently,this phenomenon may not have a specific function in intra-or interspecific communication but rather represents a byproduct of potentially widespread physiological processes.
