Foam injection is a promising solution for control of mobility in oil and gas field exploration and development,including enhanced oil recovery,matrix-acidization treatments,contaminated-aquifer remediation and gas le...Foam injection is a promising solution for control of mobility in oil and gas field exploration and development,including enhanced oil recovery,matrix-acidization treatments,contaminated-aquifer remediation and gas leakage prevention.This study presents a numerical investigation of foam behavior in a porous medium.Fractional flow method is applied to describe steady-state foam displacement in the entrance region.In this model,foam flow for the cases of excluding and including capillary pressure and for two types of gas,nitrogen(N2)and carbon dioxide(CO2)are investigated.Effects of pertinent parameters are also verified.Results indicate that the foam texture strongly governs foam flow in porous media.Required entrance region may be quite different for foam texture to accede local equilibrium,depending on the case and physical properties that are used.According to the fact that the aim of foaming of injected gas is to reduce gas mobility,results show that CO2 is a more proper injecting gas than N2.There are also some ideas presented here on improvement in foam displacement process.This study will provide an insight into future laboratory research and development of full-field foam flow in a porous medium.展开更多
Laboratory filtration experiments are employed to investigate effective well killing while minimizing its impacts on surrounding rocks.The novelty of this experimental study lies in the prolonged exposure of rock samp...Laboratory filtration experiments are employed to investigate effective well killing while minimizing its impacts on surrounding rocks.The novelty of this experimental study lies in the prolonged exposure of rock samples to the killing fluid for seven days,corresponding to the average duration of well workovers in the oilfields in Perm Krai,Russia.Our findings indicate that critical factors influencing the interactions between rocks and the killing fluid include the chemical composition of the killing fluid,the mineralogical composition of the carbonate rocks,reservoir pressure and temperature,and the contact time.Petrophysical analyses using multi-scale X-ray computed tomography,field emission scanning electron microscopy,and X-ray diffraction were conducted on samples both before and after the well killing simulation.The experiments were performed using real samples of cores,crude oil,and the killing fluid.The results from this study indicate that low-mineralized water(practically fresh water)is a carbonate rock solvent.Such water causes the dissolution of rock components,the formation of new calcite crystals and amoeba-like secretions,and the migration of small particles(clay,quartz,and carbonates).The formation of deep channels was also recorded.The assessment reveals that the change in the pH of the killing fluid indicates that the observed mineral reactions were caused by carbonate dissolution.These combined phenomena led to a decrease in the total number of voids in the core samples,which was 25%on average,predominantly among voids measuring between 45 and 70μm in size.The change in the pore distribution in the bulk of the samples resulted in decreases in porosity of 1.8%and permeability of 67.0%in the studied core samples.The results from this study indicate the unsuitability of low-mineralized water as a well killing fluid in carbonate reservoirs.The composition of the killing fluid should be optimized,for example,in terms of the ionic composition of water,which we intend to investigate in future research.展开更多
Gas condensate is one of the most different fluids in reservoir simulation due to retrograde condensation in case of pressure reduction.In this kind of fluids,two phenomena named negative inertia and positive coupling...Gas condensate is one of the most different fluids in reservoir simulation due to retrograde condensation in case of pressure reduction.In this kind of fluids,two phenomena named negative inertia and positive coupling,become significant in the high velocity zone around the wellbore.In this study,a modified black oil simulator is developed that take into account the velocity dependent relative permeability.Against the industrial simulator that assumes linear variation of transmissibilities by pressure,modified black oil nonlinear equations are solved directly without linearization.The developed code is validated by ECLIPSE simulator.The behavior of two real gas condensate fluids,a lean and a rich one,are compared with each other.For each fluid,simulations of PVT experiments are carried out to calculate black oil property applying Coats approach for gas condensate fluids.For both fluids,the proposed models for gas condensate velocity dependent relative permeability show different influence of velocity on relative permeability in the same conditions.Moreover,it is observed that higher flow rate of gas production leads to more condensate production during constant rate well testing.展开更多
The stability of acid-crude oil emulsion poses manifold issues in the oil industry.Experimentally evaluating this phenomenon may be costly and time-consuming.In contrast,machine learning models have proven effective i...The stability of acid-crude oil emulsion poses manifold issues in the oil industry.Experimentally evaluating this phenomenon may be costly and time-consuming.In contrast,machine learning models have proven effective in predicting and evaluating various phenomena.This research is the first of its kind to assess the stability of acid-crude oil emulsion,employing various classification machine learning models.For this purpose,a data set consisting of 249 experimental data points belonging to 11 different crude oil samples was collected.Three tree-based models,namely decision tree(DT),random forest(RF),and categorical boosting(CatBoost),as well as three artificial neural network models,namely radial basis function(RBF),multi-layer perceptron(MLP) and convolutional neural network(CNN),were developed based on the properties of crude oil,acid,and protective additive.The CatBoost model obtained the highest accuracy with 0.9687,followed closely by the CNN model with 0.9673.In addition,confusion matrix findings showed the superiority of the CatBoost model.Finally,by applying the SHapley Additive exPlanations(SHAP) method to analyze the impact of input parameters,it was found that the crude oil viscosity has the most significant effect on the model's output with the mean absolute SHAP value of 0.88.展开更多
Stable HCl-crude oil emulsion and its subsequent sludge formation,with detrimental impacts on oil production,may stem from acid stimulation.One major ambiguity in this process is to discern the most influential compon...Stable HCl-crude oil emulsion and its subsequent sludge formation,with detrimental impacts on oil production,may stem from acid stimulation.One major ambiguity in this process is to discern the most influential component of crude oil on the stability of formed emulsions.This fundamental question has not adequately been addressed in previous studies.In this work,the impact of de-asphalted part of crude oil(maltene)has been investigated on the acid-induced emulsion and sludge separately.Accordingly,the emulsion phase separation and the amount of formed sludge have been compared for four crude oils and their maltene samples for different concentrations of ferric ion and acidic pH values.The results of phase separation,as a criterion for emulsion stability,showed that crude oil samples formed 6 to 25 percent more stable emulsions than maltene samples,when using blank HCl.The emulsions of maltene and spent acid(pH=2)broke completely during the first 15 min after emulsification.In addition,the maltene components usually had less contribution to sludge formation in the presence of blank HCl.It was concluded that asphaltene is the key component during interaction with HCl.However,the maltene of one crude sample formed higher acid sludge in comparison to its crude oil.For acid solutions containing 3000 ppm of ferric ion,the emulsion stability increased for all crude oil and maltene samples.Moreover,the stability of some maltene emulsions increased to 48%and 100%in the presence of 3000 ppm of ferric ions.The presence of ferric ions caused forming very stable emulsions,while most of the sludge formation took place at higher pH values.Finally,it was also attained that emulsion and sludge formations could happen simultaneously.展开更多
Nanoparticles have already gained attentions for their countless potential applications in enhanced oil recovery.Nano-sized particles would help to recover trapped oil by several mechanisms including interfacial tensi...Nanoparticles have already gained attentions for their countless potential applications in enhanced oil recovery.Nano-sized particles would help to recover trapped oil by several mechanisms including interfacial tension reduction, impulsive emulsion formation and wettability alteration of porous media. The presence of dispersed nanoparticles in injected fluids would enhance the recovery process through their movement towards oil–water interface. This would cause the interfacial tension to be reduced. In this research, the effects of different types of nanoparticles and different nanoparticle concentrations on EOR processes were investigated. Different flooding experiments were investigated to reveal enhancing oil recovery mechanisms. The results showed that nanoparticles have the ability to reduce the IFT as well as contact angle, making the solid surface to more water wet. As nanoparticle concentration increases more trapped oil was produced mainly due to wettability alteration to water wet and IFT reduction. However, pore blockage was also observed due to adsorption of nanoparticles, a phenomenon which caused the injection pressure to increase. Nonetheless, such higher injection pressure could displace some trapped oil in the small pore channels out of the model. The investigated results gave a clear indication that the EOR potential of nanoparticle fluid is significant.展开更多
Phases of Cu-（0.4%-2.0%） Cr-（0.05%-0.16%） Zr alloys were analyzed in both as cast and deformed state. Solute-rich clusters of Cr, which was supposed to form during aging treatment, were observed in as cast state; ...Phases of Cu-（0.4%-2.0%） Cr-（0.05%-0.16%） Zr alloys were analyzed in both as cast and deformed state. Solute-rich clusters of Cr, which was supposed to form during aging treatment, were observed in as cast state; along with the morphology character, corresponding preferential orientation of Cr phase in as cast state was also investigated. Precipitates were observed to distribute in the matrix with a bimodal distribution, viz. coarse precipitates with dimension larger than several hundred nanometers and fine precipitates with size of 2- 10 nm. Three types of intermetallics, the common compound of Cu51Zr14, correspondingly infrequent Cu5Zr and rare Cu5Zr3, were characterized in different samples.展开更多
Most fractured carbonate oil reservoirs have oil-wet rocks.Therefore,the process of imbibing water from the fractures into the matrix is usually poor or basically does not exist due to negative capillary pressure.To a...Most fractured carbonate oil reservoirs have oil-wet rocks.Therefore,the process of imbibing water from the fractures into the matrix is usually poor or basically does not exist due to negative capillary pressure.To achieve appropriate ultimate oil recovery in these reservoirs,a water-based enhanced oil recovery method must be capable of altering the wettability of matrix blocks.Previous studies showed that carbonated water can alter wettability of carbonate oil-wet rocks toward less oil-wet or neutral wettability conditions,but the degree of modification is not high enough to allow water to imbibe spontaneously into the matrix blocks at an effective rate.In this study,we manipulated carbonated brine chemistry to enhance its wettability alteration features and hence to improve water imbibition rate and ultimate oil recovery upon spontaneous imbibition in dolomite rocks.First,the contact angle and interfacial tension(IFT)of brine/crude oil systems were measured for several synthetic brine samples with different compositions.Thereafter,two solutions with a significant difference in WAI(wettability alteration index)but approximately equal brine/oil IFT were chosen for spontaneous imbibition experiments.In the next step,spontaneous imbibition experiments at ambient and high pressures were conducted to evaluate the ability of carbonated smart water in enhancing the spontaneous imbibition rate and ultimate oil recovery in dolomite rocks.Experimental results showed that an appropriate adjustment of the imbibition brine(i.e.,carbonated smart water)chemistry improves imbibition rate of carbonated water in oil-wet dolomite rocks as well as the ultimate oil recovery.展开更多
Carbonated water injection(CWI)is known as an efficient technique for both CO2 storage and enhanced oil recovery(EOR).During CWI process,CO2 moves from the water phase into the oil phase and results in oil swelling.Th...Carbonated water injection(CWI)is known as an efficient technique for both CO2 storage and enhanced oil recovery(EOR).During CWI process,CO2 moves from the water phase into the oil phase and results in oil swelling.This mechanism is considered as a reason for EOR.Viscous fingering leading to early breakthrough and leaving a large proportion of reservoir un-swept is known as an unfavorable phenomenon during flooding trials.Generally,instability at the interface due to disturbances in porous medium promotes viscous fingering phenomenon.Connate water makes viscous fingers longer and more irregular consisting of large number of tributaries leading to the ultimate oil recovery reduction.Therefore,higher in-situ water content can worsen this condition.Besides,this water can play as a barrier between oil and gas phases and adversely affect the gas diffusion,which results in EOR reduction.On the other hand,from gas storage point of view,it should be noted that CO2 solubility is not the same in the water and oil phases.In this study for a specified water salinity,the effects of different connate water saturations(Swc)on the ultimate oil recovery and CO2 storage capacity during secondary CWI are being presented using carbonate rock samples from one of Iranian carbonate oil reservoir.The results showed higher oil recovery and CO2 storage in the case of lower connate water saturation,as 14%reduction of Swc resulted in 20%and 16%higher oil recovery and CO2 storage capacity,respectively.展开更多
Sand production from loosely consolidated reservoirs is one of the critical issues in the oil and gas in-dustry all around the world that can cause many problems,such as erosion of surface and well equip-ment,sand acc...Sand production from loosely consolidated reservoirs is one of the critical issues in the oil and gas in-dustry all around the world that can cause many problems,such as erosion of surface and well equip-ment,sand accumulation in wells and operation facilities,buckling of casing in cased-hole wells and well productivity reduction.Sand production control methods include restrictive production rate,mechanical methods(slotted liner,wire-wrapped screen,pre-packed screen,frac-pack,gravel pack,high-rate water pack)and chemical consolidation that chemical method is considered for more effectiveness in sand production alleviation due to increasing formation strength in near wellbore region.This review provides an overview on the laboratory and filed operation investigations of chemical remedy for sand production.Some used chemical agents and more common laboratory tests for evaluating the chemical performance in sand consolidation are introduced in this paper.Furthermore,the results of field operations and in-jections of chemicals into the desired formation are also reported.These results show that the chemical sand consolidation is more effective in newly perforated wells which have no sand production experi-ence and have a production history of less than two years.Finally,it was concluded that the main challenges in applying this method are permeability and capillary force reduction around the wellbore and selective injection into the targeted formation layers.展开更多
Calcite has a highly anisotropic thermal expansion coefficient, and repeated heating and cooling cycles can potentially destabilize chalks by breaking cement bonds between neighboring particles. Based on tensile stren...Calcite has a highly anisotropic thermal expansion coefficient, and repeated heating and cooling cycles can potentially destabilize chalks by breaking cement bonds between neighboring particles. Based on tensile strength measurements, we investigated how temperature cycles induce weakening of chalk.Tensile strength tests were performed on chalk specimens sampled from Kansas(USA) and Mons(Belgium), each with differing amounts of contact cement. Samples of the two chalk types were tested in dry and water-saturated states, and then exposed to 0, 15, and 30 temperature cycles in order to find out under what circumstances thermally induced tensile strength reduction occurs. The testing results show that the dry samples were not influenced by temperature cycling in either of the chalk types. However, in the water-saturated state, tensile strength is increasingly reduced with progressive numbers of temperature cycles for both chalk samples, especially for the more cemented Kansas chalk. The Kansas chalk demonstrated higher initial tensile strength compared to the less cemented Mons chalk, but the strength of both chalks was reduced by the same relative proportion when undergoing thermal cycles in the water-saturated state.展开更多
Enhanced oil recovery(EOR)methods are mostly based on different phenomena taking place at the interfaces between fluid–fluid and rock–fluid phases.Over the last decade,carbonated water injection(CWI)has been conside...Enhanced oil recovery(EOR)methods are mostly based on different phenomena taking place at the interfaces between fluid–fluid and rock–fluid phases.Over the last decade,carbonated water injection(CWI)has been considered as one of the multi-objective EOR techniques to store CO2 in the hydrocarbon bearing formations as well as improving oil recovery efficiency.During CWI process,as the reservoir pressure declines,the dissolved CO2 in the oil phase evolves and gas nucleation phenomenon would occur.As a result,it can lead to oil saturation restoration and subsequently,oil displacement due to the hysteresis effect.At this condition,CO2 would act as insitu dissolved gas into the oil phase,and play the role of an artificial solution gas drive(SGD).In this study,the effect of SGD as an extra oil recovery mechanism after secondary and tertiary CWI(SCWI-TCWI)modes has been experimentally investigated in carbonate rocks using coreflood tests.The depressurization tests resulted in more than 25%and 18%of original oil in place(OOIP)because of the SGD after SCWI and TCWI tests,respectively.From the ultimate enhanced oil recovery point of view,the efficiency of SGD was observed to be more than one-third of that of CWI itself.Furthermore,the pressure drop data revealed that the system pressure depends more on the oil production pattern than water production.展开更多
Temperature history can have a significant effect on the strength of water-saturated chalk.In this study,hydrostatic stress cycles are applied to understand the mechanical response of chalk samples exposed to temperat...Temperature history can have a significant effect on the strength of water-saturated chalk.In this study,hydrostatic stress cycles are applied to understand the mechanical response of chalk samples exposed to temperature cycling between each stress cycle,compared to the samples tested at a constant temperature.The total accumulated strain during a stress cycle and the irreversible strain are reported.Chalk samples from Kansas(USA)and Mons(Belgium),with different degrees of induration(i.e.amount of contact cementation),were used.The samples were saturated with equilibrated water(polar)and nonpolar Isopar H oil to quantify water weakening.All samples tested during 10 stress cycles with varying temperature(i.e.temperature cycled in between each stress cycle)accumulated more strain than those tested at constant temperatures.All the stress cycles were performed at 30℃.The two chalk types behaved similarly when saturated with Isopar H oil,but differently when saturated with water.When saturated with water,the stronger Kansas chalk accumulated more total strain and more irreversible strain within each stress cycle than the weaker Mons chalk.展开更多
Imbibition of water,as wetting phase in oil-wet fractured carbonate reservoirs,plays a key role in fluid flow between matrix and fracture system.The type of injected seawater and its chemistry would profoundly influen...Imbibition of water,as wetting phase in oil-wet fractured carbonate reservoirs,plays a key role in fluid flow between matrix and fracture system.The type of injected seawater and its chemistry would profoundly influence the imbibition process.In this study,the impact of smart water(a brine that its ions have been adjusted to facilitate oil recovery)and low salinity water on co-and counter-current imbibition processes for oil-wet carbonate cores has been experimentally investigated.The results show an increase of about 10% in oil recovery for co-and counter-currents for smart seawater imbibition compared to that of low salinity seawater.In addition,as a result of the influence of co-and counter-current on each other,by co-current removal from one core face,the countercurrent in the other face would be intensified by as much as about 75%.A close examination of different lengths(5,7 and 9 cm)of carbonate cores with the same permeability revealed that by decreasing porous medium length,the amount of counter-current producing oil would be decreased so that in the 5 cm core,counter current oil production will not happen.For similar core lengths by increasing permeability,the share of counter current flow would be decreased approximately 18% since the capillary pressure could not overcome non-wetting phase viscous forces.Considering the role of matrix length along with a modified brine(which is designed according to the matrix mixture)strengthen the relevant mechanisms to have more oil production so that the higher thickness of matrix causes the higher amount of co-current oil producing and consequently more total recovery.展开更多
Congenital bilateral absence of vas deferens （CBAVD） is a manifestation of the mildest form of cystic fibrosis （CF） and is characterized by obstructive azoospermia in otherwise healthy patients. Owing to the avail...Congenital bilateral absence of vas deferens （CBAVD） is a manifestation of the mildest form of cystic fibrosis （CF） and is characterized by obstructive azoospermia in otherwise healthy patients. Owing to the availability of assisted reproductive technology, CBAVD patients can father children. These fathers are at risk of transmitting a mutated allele of the CF transmembrane conductance regulator （CFTR） gene, responsible for CF, to their offspring. The identification of mutations in both CFTR alleles in CBAVD patients is a crucial requirement for calculating the risk of producing a child with full-blown CF if the female partner is a healthy CF carrier. However, in the majority of CBAVD patients, conventional mutation screening is not able to detect mutations in both CFTR alleles, and this difficulty hampers the execution of correct genetic counselling. To obtain information about the most represented CFTR mutations in CBAVD patients, we analysed 23 CBAVD patients, 15 of whom had a single CFTR mutation after screening for 36 mutations and the 5T allele. The search for the second CFTR mutation in these cases was performed by using a triplex approach： （i） first, a reverse dot-blot analysis was performed to detect mutations with regional impact; （ii） next, multiple ligation-dependent probe amplification assays were conducted to search for large rearrangements; and （iii） finally, denaturing high-performance liquid chromatography was used to search for point mutations in the entire coding region. Using these approaches, the second CFTR mutation was detected in six patients, which increased the final detection rate to 60.8%.展开更多
Lung oncogenesis relies on intracellular cysteine to overcome oxidative stress.Several tumor types,including non-small cell lung cancer(NSCLC),upregulate the system x-c cystine/glutamate antiporter(xCT)through overexp...Lung oncogenesis relies on intracellular cysteine to overcome oxidative stress.Several tumor types,including non-small cell lung cancer(NSCLC),upregulate the system x-c cystine/glutamate antiporter(xCT)through overexpression of the cystine transporter SLC7A11,thus sustaining intracellular cysteine levels to support glutathione synthesis.Nuclear factor erythroid 2-related factor 2(NRF2)serves as a master regulator of oxidative stress resistance by regulating SLC7A11,whereas Kelch-like ECH-associated protein(KEAP1)acts as a cytoplasmic repressor of the oxidative responsive transcription factor NRF2.Mutations in KEAP1/NRF2 and p53 induce SLC7A11 activation in NSCLC.Extracellular cystine is crucial in supplying the intracellular cysteine levels necessary to combat oxidative stress.Disruptions in cystine availability lead to iron-dependent lipid peroxidation,thus resulting in a type of cell death called ferroptosis.Pharmacologic inhibitors of xCT(either SLC7A11 or GPX4)induce ferroptosis of NSCLC cells and other tumor types.When cystine uptake is impaired,the intracellular cysteine pool can be sustained by the transsulfuration pathway,which is catalyzed by cystathionine-B-synthase(CBS)and cystathionine g-lyase(CSE).The involvement of exogenous cysteine/cystine and the transsulfuration pathway in the cysteine pool and downstream metabolites results in compromised CD8^(+)T cell function and evasion of immunotherapy,diminishing immune response and potentially reducing the effectiveness of immunotherapeutic interventions.Pyroptosis is a previously unrecognized form of regulated cell death.In NSCLCs driven by EGFR,ALK,or KRAS,selective inhibitors induce pyroptotic cell death as well as apoptosis.After targeted therapy,the mitochondrial intrinsic apoptotic pathway is activated,thus leading to the cleavage and activation of caspase-3.Consequently,gasdermin E is activated,thus leading to permeabilization of the cytoplasmic membrane and cell-lytic pyroptosis(indicated by characteristic cell membrane ballooning).Breakthroughs in KRAS G12C allele-specific inhibitors and potential mechanisms of resistance are also discussed herein.展开更多
文摘Foam injection is a promising solution for control of mobility in oil and gas field exploration and development,including enhanced oil recovery,matrix-acidization treatments,contaminated-aquifer remediation and gas leakage prevention.This study presents a numerical investigation of foam behavior in a porous medium.Fractional flow method is applied to describe steady-state foam displacement in the entrance region.In this model,foam flow for the cases of excluding and including capillary pressure and for two types of gas,nitrogen(N2)and carbon dioxide(CO2)are investigated.Effects of pertinent parameters are also verified.Results indicate that the foam texture strongly governs foam flow in porous media.Required entrance region may be quite different for foam texture to accede local equilibrium,depending on the case and physical properties that are used.According to the fact that the aim of foaming of injected gas is to reduce gas mobility,results show that CO2 is a more proper injecting gas than N2.There are also some ideas presented here on improvement in foam displacement process.This study will provide an insight into future laboratory research and development of full-field foam flow in a porous medium.
基金funded by the Ministry of Science and Higher Education of the Russian Federation(FSNM-2024-0005).
文摘Laboratory filtration experiments are employed to investigate effective well killing while minimizing its impacts on surrounding rocks.The novelty of this experimental study lies in the prolonged exposure of rock samples to the killing fluid for seven days,corresponding to the average duration of well workovers in the oilfields in Perm Krai,Russia.Our findings indicate that critical factors influencing the interactions between rocks and the killing fluid include the chemical composition of the killing fluid,the mineralogical composition of the carbonate rocks,reservoir pressure and temperature,and the contact time.Petrophysical analyses using multi-scale X-ray computed tomography,field emission scanning electron microscopy,and X-ray diffraction were conducted on samples both before and after the well killing simulation.The experiments were performed using real samples of cores,crude oil,and the killing fluid.The results from this study indicate that low-mineralized water(practically fresh water)is a carbonate rock solvent.Such water causes the dissolution of rock components,the formation of new calcite crystals and amoeba-like secretions,and the migration of small particles(clay,quartz,and carbonates).The formation of deep channels was also recorded.The assessment reveals that the change in the pH of the killing fluid indicates that the observed mineral reactions were caused by carbonate dissolution.These combined phenomena led to a decrease in the total number of voids in the core samples,which was 25%on average,predominantly among voids measuring between 45 and 70μm in size.The change in the pore distribution in the bulk of the samples resulted in decreases in porosity of 1.8%and permeability of 67.0%in the studied core samples.The results from this study indicate the unsuitability of low-mineralized water as a well killing fluid in carbonate reservoirs.The composition of the killing fluid should be optimized,for example,in terms of the ionic composition of water,which we intend to investigate in future research.
文摘Gas condensate is one of the most different fluids in reservoir simulation due to retrograde condensation in case of pressure reduction.In this kind of fluids,two phenomena named negative inertia and positive coupling,become significant in the high velocity zone around the wellbore.In this study,a modified black oil simulator is developed that take into account the velocity dependent relative permeability.Against the industrial simulator that assumes linear variation of transmissibilities by pressure,modified black oil nonlinear equations are solved directly without linearization.The developed code is validated by ECLIPSE simulator.The behavior of two real gas condensate fluids,a lean and a rich one,are compared with each other.For each fluid,simulations of PVT experiments are carried out to calculate black oil property applying Coats approach for gas condensate fluids.For both fluids,the proposed models for gas condensate velocity dependent relative permeability show different influence of velocity on relative permeability in the same conditions.Moreover,it is observed that higher flow rate of gas production leads to more condensate production during constant rate well testing.
文摘The stability of acid-crude oil emulsion poses manifold issues in the oil industry.Experimentally evaluating this phenomenon may be costly and time-consuming.In contrast,machine learning models have proven effective in predicting and evaluating various phenomena.This research is the first of its kind to assess the stability of acid-crude oil emulsion,employing various classification machine learning models.For this purpose,a data set consisting of 249 experimental data points belonging to 11 different crude oil samples was collected.Three tree-based models,namely decision tree(DT),random forest(RF),and categorical boosting(CatBoost),as well as three artificial neural network models,namely radial basis function(RBF),multi-layer perceptron(MLP) and convolutional neural network(CNN),were developed based on the properties of crude oil,acid,and protective additive.The CatBoost model obtained the highest accuracy with 0.9687,followed closely by the CNN model with 0.9673.In addition,confusion matrix findings showed the superiority of the CatBoost model.Finally,by applying the SHapley Additive exPlanations(SHAP) method to analyze the impact of input parameters,it was found that the crude oil viscosity has the most significant effect on the model's output with the mean absolute SHAP value of 0.88.
文摘Stable HCl-crude oil emulsion and its subsequent sludge formation,with detrimental impacts on oil production,may stem from acid stimulation.One major ambiguity in this process is to discern the most influential component of crude oil on the stability of formed emulsions.This fundamental question has not adequately been addressed in previous studies.In this work,the impact of de-asphalted part of crude oil(maltene)has been investigated on the acid-induced emulsion and sludge separately.Accordingly,the emulsion phase separation and the amount of formed sludge have been compared for four crude oils and their maltene samples for different concentrations of ferric ion and acidic pH values.The results of phase separation,as a criterion for emulsion stability,showed that crude oil samples formed 6 to 25 percent more stable emulsions than maltene samples,when using blank HCl.The emulsions of maltene and spent acid(pH=2)broke completely during the first 15 min after emulsification.In addition,the maltene components usually had less contribution to sludge formation in the presence of blank HCl.It was concluded that asphaltene is the key component during interaction with HCl.However,the maltene of one crude sample formed higher acid sludge in comparison to its crude oil.For acid solutions containing 3000 ppm of ferric ion,the emulsion stability increased for all crude oil and maltene samples.Moreover,the stability of some maltene emulsions increased to 48%and 100%in the presence of 3000 ppm of ferric ions.The presence of ferric ions caused forming very stable emulsions,while most of the sludge formation took place at higher pH values.Finally,it was also attained that emulsion and sludge formations could happen simultaneously.
文摘Nanoparticles have already gained attentions for their countless potential applications in enhanced oil recovery.Nano-sized particles would help to recover trapped oil by several mechanisms including interfacial tension reduction, impulsive emulsion formation and wettability alteration of porous media. The presence of dispersed nanoparticles in injected fluids would enhance the recovery process through their movement towards oil–water interface. This would cause the interfacial tension to be reduced. In this research, the effects of different types of nanoparticles and different nanoparticle concentrations on EOR processes were investigated. Different flooding experiments were investigated to reveal enhancing oil recovery mechanisms. The results showed that nanoparticles have the ability to reduce the IFT as well as contact angle, making the solid surface to more water wet. As nanoparticle concentration increases more trapped oil was produced mainly due to wettability alteration to water wet and IFT reduction. However, pore blockage was also observed due to adsorption of nanoparticles, a phenomenon which caused the injection pressure to increase. Nonetheless, such higher injection pressure could displace some trapped oil in the small pore channels out of the model. The investigated results gave a clear indication that the EOR potential of nanoparticle fluid is significant.
文摘Phases of Cu-（0.4%-2.0%） Cr-（0.05%-0.16%） Zr alloys were analyzed in both as cast and deformed state. Solute-rich clusters of Cr, which was supposed to form during aging treatment, were observed in as cast state; along with the morphology character, corresponding preferential orientation of Cr phase in as cast state was also investigated. Precipitates were observed to distribute in the matrix with a bimodal distribution, viz. coarse precipitates with dimension larger than several hundred nanometers and fine precipitates with size of 2- 10 nm. Three types of intermetallics, the common compound of Cu51Zr14, correspondingly infrequent Cu5Zr and rare Cu5Zr3, were characterized in different samples.
基金financial support from National Iranian South Oil Company(NISOC)
文摘Most fractured carbonate oil reservoirs have oil-wet rocks.Therefore,the process of imbibing water from the fractures into the matrix is usually poor or basically does not exist due to negative capillary pressure.To achieve appropriate ultimate oil recovery in these reservoirs,a water-based enhanced oil recovery method must be capable of altering the wettability of matrix blocks.Previous studies showed that carbonated water can alter wettability of carbonate oil-wet rocks toward less oil-wet or neutral wettability conditions,but the degree of modification is not high enough to allow water to imbibe spontaneously into the matrix blocks at an effective rate.In this study,we manipulated carbonated brine chemistry to enhance its wettability alteration features and hence to improve water imbibition rate and ultimate oil recovery upon spontaneous imbibition in dolomite rocks.First,the contact angle and interfacial tension(IFT)of brine/crude oil systems were measured for several synthetic brine samples with different compositions.Thereafter,two solutions with a significant difference in WAI(wettability alteration index)but approximately equal brine/oil IFT were chosen for spontaneous imbibition experiments.In the next step,spontaneous imbibition experiments at ambient and high pressures were conducted to evaluate the ability of carbonated smart water in enhancing the spontaneous imbibition rate and ultimate oil recovery in dolomite rocks.Experimental results showed that an appropriate adjustment of the imbibition brine(i.e.,carbonated smart water)chemistry improves imbibition rate of carbonated water in oil-wet dolomite rocks as well as the ultimate oil recovery.
文摘Carbonated water injection(CWI)is known as an efficient technique for both CO2 storage and enhanced oil recovery(EOR).During CWI process,CO2 moves from the water phase into the oil phase and results in oil swelling.This mechanism is considered as a reason for EOR.Viscous fingering leading to early breakthrough and leaving a large proportion of reservoir un-swept is known as an unfavorable phenomenon during flooding trials.Generally,instability at the interface due to disturbances in porous medium promotes viscous fingering phenomenon.Connate water makes viscous fingers longer and more irregular consisting of large number of tributaries leading to the ultimate oil recovery reduction.Therefore,higher in-situ water content can worsen this condition.Besides,this water can play as a barrier between oil and gas phases and adversely affect the gas diffusion,which results in EOR reduction.On the other hand,from gas storage point of view,it should be noted that CO2 solubility is not the same in the water and oil phases.In this study for a specified water salinity,the effects of different connate water saturations(Swc)on the ultimate oil recovery and CO2 storage capacity during secondary CWI are being presented using carbonate rock samples from one of Iranian carbonate oil reservoir.The results showed higher oil recovery and CO2 storage in the case of lower connate water saturation,as 14%reduction of Swc resulted in 20%and 16%higher oil recovery and CO2 storage capacity,respectively.
文摘Sand production from loosely consolidated reservoirs is one of the critical issues in the oil and gas in-dustry all around the world that can cause many problems,such as erosion of surface and well equip-ment,sand accumulation in wells and operation facilities,buckling of casing in cased-hole wells and well productivity reduction.Sand production control methods include restrictive production rate,mechanical methods(slotted liner,wire-wrapped screen,pre-packed screen,frac-pack,gravel pack,high-rate water pack)and chemical consolidation that chemical method is considered for more effectiveness in sand production alleviation due to increasing formation strength in near wellbore region.This review provides an overview on the laboratory and filed operation investigations of chemical remedy for sand production.Some used chemical agents and more common laboratory tests for evaluating the chemical performance in sand consolidation are introduced in this paper.Furthermore,the results of field operations and in-jections of chemicals into the desired formation are also reported.These results show that the chemical sand consolidation is more effective in newly perforated wells which have no sand production experi-ence and have a production history of less than two years.Finally,it was concluded that the main challenges in applying this method are permeability and capillary force reduction around the wellbore and selective injection into the targeted formation layers.
文摘Calcite has a highly anisotropic thermal expansion coefficient, and repeated heating and cooling cycles can potentially destabilize chalks by breaking cement bonds between neighboring particles. Based on tensile strength measurements, we investigated how temperature cycles induce weakening of chalk.Tensile strength tests were performed on chalk specimens sampled from Kansas(USA) and Mons(Belgium), each with differing amounts of contact cement. Samples of the two chalk types were tested in dry and water-saturated states, and then exposed to 0, 15, and 30 temperature cycles in order to find out under what circumstances thermally induced tensile strength reduction occurs. The testing results show that the dry samples were not influenced by temperature cycling in either of the chalk types. However, in the water-saturated state, tensile strength is increasingly reduced with progressive numbers of temperature cycles for both chalk samples, especially for the more cemented Kansas chalk. The Kansas chalk demonstrated higher initial tensile strength compared to the less cemented Mons chalk, but the strength of both chalks was reduced by the same relative proportion when undergoing thermal cycles in the water-saturated state.
文摘Enhanced oil recovery(EOR)methods are mostly based on different phenomena taking place at the interfaces between fluid–fluid and rock–fluid phases.Over the last decade,carbonated water injection(CWI)has been considered as one of the multi-objective EOR techniques to store CO2 in the hydrocarbon bearing formations as well as improving oil recovery efficiency.During CWI process,as the reservoir pressure declines,the dissolved CO2 in the oil phase evolves and gas nucleation phenomenon would occur.As a result,it can lead to oil saturation restoration and subsequently,oil displacement due to the hysteresis effect.At this condition,CO2 would act as insitu dissolved gas into the oil phase,and play the role of an artificial solution gas drive(SGD).In this study,the effect of SGD as an extra oil recovery mechanism after secondary and tertiary CWI(SCWI-TCWI)modes has been experimentally investigated in carbonate rocks using coreflood tests.The depressurization tests resulted in more than 25%and 18%of original oil in place(OOIP)because of the SGD after SCWI and TCWI tests,respectively.From the ultimate enhanced oil recovery point of view,the efficiency of SGD was observed to be more than one-third of that of CWI itself.Furthermore,the pressure drop data revealed that the system pressure depends more on the oil production pattern than water production.
文摘Temperature history can have a significant effect on the strength of water-saturated chalk.In this study,hydrostatic stress cycles are applied to understand the mechanical response of chalk samples exposed to temperature cycling between each stress cycle,compared to the samples tested at a constant temperature.The total accumulated strain during a stress cycle and the irreversible strain are reported.Chalk samples from Kansas(USA)and Mons(Belgium),with different degrees of induration(i.e.amount of contact cementation),were used.The samples were saturated with equilibrated water(polar)and nonpolar Isopar H oil to quantify water weakening.All samples tested during 10 stress cycles with varying temperature(i.e.temperature cycled in between each stress cycle)accumulated more strain than those tested at constant temperatures.All the stress cycles were performed at 30℃.The two chalk types behaved similarly when saturated with Isopar H oil,but differently when saturated with water.When saturated with water,the stronger Kansas chalk accumulated more total strain and more irreversible strain within each stress cycle than the weaker Mons chalk.
文摘Imbibition of water,as wetting phase in oil-wet fractured carbonate reservoirs,plays a key role in fluid flow between matrix and fracture system.The type of injected seawater and its chemistry would profoundly influence the imbibition process.In this study,the impact of smart water(a brine that its ions have been adjusted to facilitate oil recovery)and low salinity water on co-and counter-current imbibition processes for oil-wet carbonate cores has been experimentally investigated.The results show an increase of about 10% in oil recovery for co-and counter-currents for smart seawater imbibition compared to that of low salinity seawater.In addition,as a result of the influence of co-and counter-current on each other,by co-current removal from one core face,the countercurrent in the other face would be intensified by as much as about 75%.A close examination of different lengths(5,7 and 9 cm)of carbonate cores with the same permeability revealed that by decreasing porous medium length,the amount of counter-current producing oil would be decreased so that in the 5 cm core,counter current oil production will not happen.For similar core lengths by increasing permeability,the share of counter current flow would be decreased approximately 18% since the capillary pressure could not overcome non-wetting phase viscous forces.Considering the role of matrix length along with a modified brine(which is designed according to the matrix mixture)strengthen the relevant mechanisms to have more oil production so that the higher thickness of matrix causes the higher amount of co-current oil producing and consequently more total recovery.
文摘Congenital bilateral absence of vas deferens （CBAVD） is a manifestation of the mildest form of cystic fibrosis （CF） and is characterized by obstructive azoospermia in otherwise healthy patients. Owing to the availability of assisted reproductive technology, CBAVD patients can father children. These fathers are at risk of transmitting a mutated allele of the CF transmembrane conductance regulator （CFTR） gene, responsible for CF, to their offspring. The identification of mutations in both CFTR alleles in CBAVD patients is a crucial requirement for calculating the risk of producing a child with full-blown CF if the female partner is a healthy CF carrier. However, in the majority of CBAVD patients, conventional mutation screening is not able to detect mutations in both CFTR alleles, and this difficulty hampers the execution of correct genetic counselling. To obtain information about the most represented CFTR mutations in CBAVD patients, we analysed 23 CBAVD patients, 15 of whom had a single CFTR mutation after screening for 36 mutations and the 5T allele. The search for the second CFTR mutation in these cases was performed by using a triplex approach： （i） first, a reverse dot-blot analysis was performed to detect mutations with regional impact; （ii） next, multiple ligation-dependent probe amplification assays were conducted to search for large rearrangements; and （iii） finally, denaturing high-performance liquid chromatography was used to search for point mutations in the entire coding region. Using these approaches, the second CFTR mutation was detected in six patients, which increased the final detection rate to 60.8%.
基金supported by a Spanish Association Against Cancer(AECC)grant,(grant No.PROYE18012ROSE)support from Julián Santamaría Vali?o to the IOR Foundation。
文摘Lung oncogenesis relies on intracellular cysteine to overcome oxidative stress.Several tumor types,including non-small cell lung cancer(NSCLC),upregulate the system x-c cystine/glutamate antiporter(xCT)through overexpression of the cystine transporter SLC7A11,thus sustaining intracellular cysteine levels to support glutathione synthesis.Nuclear factor erythroid 2-related factor 2(NRF2)serves as a master regulator of oxidative stress resistance by regulating SLC7A11,whereas Kelch-like ECH-associated protein(KEAP1)acts as a cytoplasmic repressor of the oxidative responsive transcription factor NRF2.Mutations in KEAP1/NRF2 and p53 induce SLC7A11 activation in NSCLC.Extracellular cystine is crucial in supplying the intracellular cysteine levels necessary to combat oxidative stress.Disruptions in cystine availability lead to iron-dependent lipid peroxidation,thus resulting in a type of cell death called ferroptosis.Pharmacologic inhibitors of xCT(either SLC7A11 or GPX4)induce ferroptosis of NSCLC cells and other tumor types.When cystine uptake is impaired,the intracellular cysteine pool can be sustained by the transsulfuration pathway,which is catalyzed by cystathionine-B-synthase(CBS)and cystathionine g-lyase(CSE).The involvement of exogenous cysteine/cystine and the transsulfuration pathway in the cysteine pool and downstream metabolites results in compromised CD8^(+)T cell function and evasion of immunotherapy,diminishing immune response and potentially reducing the effectiveness of immunotherapeutic interventions.Pyroptosis is a previously unrecognized form of regulated cell death.In NSCLCs driven by EGFR,ALK,or KRAS,selective inhibitors induce pyroptotic cell death as well as apoptosis.After targeted therapy,the mitochondrial intrinsic apoptotic pathway is activated,thus leading to the cleavage and activation of caspase-3.Consequently,gasdermin E is activated,thus leading to permeabilization of the cytoplasmic membrane and cell-lytic pyroptosis(indicated by characteristic cell membrane ballooning).Breakthroughs in KRAS G12C allele-specific inhibitors and potential mechanisms of resistance are also discussed herein.
