In order to reduce the effort in the integration and actualization of heterogeneous healthcare legacy systems that should share a common database, we propose the creation of an interoperability bus using the HL7 stand...In order to reduce the effort in the integration and actualization of heterogeneous healthcare legacy systems that should share a common database, we propose the creation of an interoperability bus using the HL7 standard—the HL7Middleware. This interoperability bus is an intermediate layer responsible for the communication between a database, health information systems and medical equipment, called HL7Server. Connected systems use the HL7 messaging semantics to store and retrieve data from the database. We validate our approach with respect to two different criteria: performance and integration costs. Benchmark tests were executed with and without the use of HL7Middleware and with different network bandwidths. These results demonstrated that the performance of the interoperability bus is higher when compared to traditional database access for larger volumes of data and when the bandwidth of the user is considerably lower than the bandwidth of the connection between HL7Server and database. The overall development and deployment cost was considered low and the reusability degree of wrapper code was considered high, thus suggesting a progressive reduction of the integration costs of additional services and subsystems of an organization.展开更多
In this paper,an irregular displacement-based lensless wide-field microscopy imaging platform is presented by combining digital in-line holography and computational pixel super-resolution using multi-frame processing....In this paper,an irregular displacement-based lensless wide-field microscopy imaging platform is presented by combining digital in-line holography and computational pixel super-resolution using multi-frame processing.The samples are illuminated by a nearly coherent illumination system,where the hologram shadows are projected into a complementary metal-oxide semiconductor-based imaging sensor.To increase the resolution,a multi-frame pixel resolution approach is employed to produce a single holographic image from multiple frame observations of the scene,with small planar displacements.Displacements are resolved by a hybrid approach:(i)alignment of the LR images by a fast feature-based registration method,and(ii)fine adjustment of the sub-pixel information using a continuous optimization approach designed to find the global optimum solution.Numerical method for phase-retrieval is applied to decode the signal and reconstruct the morphological details of the analyzed sample.The presented approach was evaluated with various biological samples including sperm and platelets,whose dimensions are in the order of a few microns.The obtained results demonstrate a spatial resolution of 1.55 μm on a field-of-view of<30 mm^(2).展开更多
文摘In order to reduce the effort in the integration and actualization of heterogeneous healthcare legacy systems that should share a common database, we propose the creation of an interoperability bus using the HL7 standard—the HL7Middleware. This interoperability bus is an intermediate layer responsible for the communication between a database, health information systems and medical equipment, called HL7Server. Connected systems use the HL7 messaging semantics to store and retrieve data from the database. We validate our approach with respect to two different criteria: performance and integration costs. Benchmark tests were executed with and without the use of HL7Middleware and with different network bandwidths. These results demonstrated that the performance of the interoperability bus is higher when compared to traditional database access for larger volumes of data and when the bandwidth of the user is considerably lower than the bandwidth of the connection between HL7Server and database. The overall development and deployment cost was considered low and the reusability degree of wrapper code was considered high, thus suggesting a progressive reduction of the integration costs of additional services and subsystems of an organization.
基金We would like to acknowledge National Institute of Health(NIH)NIH R01AI093282,NIH R01AI081534,NIH U54EB15408,NIH R21AI087107,and Brigham and Women’s Hospital-BRI Translatable Technologies and Care Innovation GrantWe would also like to acknowledge the support provided by the Brazilian National Council for Scientific and Technological Development(process 551967/2011-0)
文摘In this paper,an irregular displacement-based lensless wide-field microscopy imaging platform is presented by combining digital in-line holography and computational pixel super-resolution using multi-frame processing.The samples are illuminated by a nearly coherent illumination system,where the hologram shadows are projected into a complementary metal-oxide semiconductor-based imaging sensor.To increase the resolution,a multi-frame pixel resolution approach is employed to produce a single holographic image from multiple frame observations of the scene,with small planar displacements.Displacements are resolved by a hybrid approach:(i)alignment of the LR images by a fast feature-based registration method,and(ii)fine adjustment of the sub-pixel information using a continuous optimization approach designed to find the global optimum solution.Numerical method for phase-retrieval is applied to decode the signal and reconstruct the morphological details of the analyzed sample.The presented approach was evaluated with various biological samples including sperm and platelets,whose dimensions are in the order of a few microns.The obtained results demonstrate a spatial resolution of 1.55 μm on a field-of-view of<30 mm^(2).
