As silicon-based transistors face fundamental scaling limits,the search for breakthrough alternatives has led to innovations in 3D architectures,heterogeneous integration,and sub-3 nm semiconductor body thicknesses.Ho...As silicon-based transistors face fundamental scaling limits,the search for breakthrough alternatives has led to innovations in 3D architectures,heterogeneous integration,and sub-3 nm semiconductor body thicknesses.However,the true effectiveness of these advancements lies in the seamless integration of alternative semiconductors tailored for next-generation transistors.In this review,we highlight key advances that enhance both scalability and switching performance by leveraging emerging semiconductor materials.Among the most promising candidates are 2D van der Waals semiconductors,Mott insulators,and amorphous oxide semiconductors,which offer not only unique electrical properties but also low-power operation and high carrier mobility.Additionally,we explore the synergistic interactions between these novel semiconductors and advanced gate dielectrics,including high-K materials,ferroelectrics,and atomically thin hexagonal boron nitride layers.Beyond introducing these novel material configurations,we address critical challenges such as leakage current and long-term device reliability,which become increasingly crucial as transistors scale down to atomic dimensions.Through concrete examples showcasing the potential of these materials in transistors,we provide key insights into overcoming fundamental obstacles—such as device reliability,scaling down limitations,and extended applications in artificial intelligence—ultimately paving the way for the development of future transistor technologies.展开更多
Flexible electronics face critical challenges in achieving monolithic three-dimensional(3D)integration,including material compatibility,structural stability,and scalable fabrication methods.Inspired by the tactile sen...Flexible electronics face critical challenges in achieving monolithic three-dimensional(3D)integration,including material compatibility,structural stability,and scalable fabrication methods.Inspired by the tactile sensing mechanism of the human skin,we have developed a flexible monolithic 3D-integrated tactile sensing system based on a holey MXene paste,where each vertical one-body unit simultaneously functions as a microsupercapacitor and pressure sensor.The in-plane mesopores of MXene significantly improve ion accessibility,mitigate the self-stacking of nanosheets,and allow the holey MXene to multifunctionally act as a sensing material,an active electrode,and a conductive interconnect,thus drastically reducing the interface mismatch and enhancing the mechanical robustness.Furthermore,we fabricate a large-scale device using a blade-coating and stamping method,which demonstrates excellent mechanical flexibility,low-power consumption,rapid response,and stable long-term operation.As a proof-of-concept application,we integrate our sensing array into a smart access control system,leveraging deep learning to accurately identify users based on their unique pressing behaviors.This study provides a promising approach for designing highly integrated,intelligent,and flexible electronic systems for advanced human-computer interactions and personalized electronics.展开更多
Protein aggregates,mitochondrial import stress and neurodegenerative disorders:A salient hallmark of several neurodegenerative diseases,including Parkinson’s disease,is the abundance of protein aggregates(Goiran et a...Protein aggregates,mitochondrial import stress and neurodegenerative disorders:A salient hallmark of several neurodegenerative diseases,including Parkinson’s disease,is the abundance of protein aggregates(Goiran et al.,2022).This molecular event is believed to lead to activation of stress pathways ultimately resulting in cellular dysfunction(Eldeeb et al.,2022).Accordingly,many lines of research investigations focused on dampening the formation of protein aggregates or augmenting the clearance of protein aggregates as a potential therapeutic strategy to counteract the progression of neurodegenerative diseases,albeit with little success(Costa-Mattioli and Walter,2020).Cell stress cues such as the accumulation of protein aggregates lead to the activation of stress response pathways that aid cells in responding to the damage.Despite the notion that the transient activation of these pathways helps cells cope with stressors,persistent activation can induce unwanted apoptosis of cells and reduce overall tissue strength as well as lead to an accumulation of aggregation-prone proteins(Hetz and Papa,2018).Mutations in proteins involved in stress signaling termination can cause conditions like ataxia and early-onset dementia(Conroy et al.,2014).Therefore,it is crucial for stress response signaling to be turned off once conditions have improved.Nevertheless,the mechanisms by which cells silence these signals are still elusive.展开更多
Covert timing channels(CTC)exploit network resources to establish hidden communication pathways,posing signi cant risks to data security and policy compliance.erefore,detecting such hidden and dangerous threats remain...Covert timing channels(CTC)exploit network resources to establish hidden communication pathways,posing signi cant risks to data security and policy compliance.erefore,detecting such hidden and dangerous threats remains one of the security challenges. is paper proposes LinguTimeX,a new framework that combines natural language processing with arti cial intelligence,along with explainable Arti cial Intelligence(AI)not only to detect CTC but also to provide insights into the decision process.LinguTimeX performs multidimensional feature extraction by fusing linguistic attributes with temporal network patterns to identify covert channels precisely.LinguTimeX demonstrates strong e ectiveness in detecting CTC across multiple languages;namely English,Arabic,and Chinese.Speci cally,the LSTM and RNN models achieved F1 scores of 90%on the English dataset,89%on the Arabic dataset,and 88%on the Chinese dataset,showcasing their superior performance and ability to generalize across multiple languages. is highlights their robustness in detecting CTCs within security systems,regardless of the language or cultural context of the data.In contrast,the DeepForest model produced F1-scores ranging from 86%to 87%across the same datasets,further con rming its e ectiveness in CTC detection.Although other algorithms also showed reasonable accuracy,the LSTM and RNN models consistently outperformed them in multilingual settings,suggesting that deep learning models might be better suited for this particular problem.展开更多
Objective Selective estrogen receptor modulators(SERMs)have demonstrated efficacy in the treatment of hypogonadism in males and male factor infertility.Two SERMs,clomiphene citrate and tamoxifen,are now prescribed for...Objective Selective estrogen receptor modulators(SERMs)have demonstrated efficacy in the treatment of hypogonadism in males and male factor infertility.Two SERMs,clomiphene citrate and tamoxifen,are now prescribed for off-label use to treat both conditions in males.However,existing literature compares mixed protocols with active management.We aimed to conduct a meta-analysis to evaluate the effect of clomiphene and tamoxifen versus placebo on natural pregnancy rates.Methods We conducted a comprehensive systematic review of electronic databases:MEDLINE,PubMed/PMC,EMBASE,CINAHL,Cochrane Central Register of Controlled Trials(CENTRAL),Scopus,Google Scholar,and Web of Science.Articles satisfying all selection criteria were analyzed.The primary outcome was the incidence of pregnancy after receiving the treatment.Secondary outcomes included serum follicle-stimulating hormone,luteinizing hormone,and testosterone levels,and sperm count and motility.We calculated the pooled odds ratio,risk ratio,and risk difference to ascertain possible alterations in the direction of the pooled effect size.Results Ten randomized controlled trials were ultimately included and underwent data extraction.Clomiphene citrate and placebo groups had similar pregnancy rates(10.4%and 7.1%,respectively;odds ratio 1.30[95%confidence interval 0.27–6.17];p=0.74).No meta-analysis could be calculated for pregnancy rates in tamoxifen versus placebo groups.Heterogeneity among the studies of both SERMs ranged from low to high.Conclusion Although clomiphene citrate and tamoxifen are often used off-label for the treatment of male infertility secondary to hypogonadism,studies of SERMs in the treatment of idiopathic male factor infertility are limited and heterogenous,preventing this meta-analysis from investigating the efficacy of SERMs on male infertility.The effect of clomiphene citrate or tamoxifen on the pregnancy rate remains uncertain.展开更多
This study was used oceanographic database in the Sea of Okhotsk between the period from 1929 to 2020(131286 stations).The paper used gas hydrate dissociation parameters for the“pure methane-seawater”system obtained...This study was used oceanographic database in the Sea of Okhotsk between the period from 1929 to 2020(131286 stations).The paper used gas hydrate dissociation parameters for the“pure methane-seawater”system obtained in the study by Dickens GR and Quinby-Hunt MS.The results have elucidated the spatiotemporal variability of distribution of such parameters at the upper boundary of the gas hydrate stability zone(GHSZ)as water temperature,salinity,and top depth of the stability zone.As the study has shown(based on average long-term spatial distributions),the minimum temperature and depth values of the GHSZ upper boundary in the Sea of Okhotsk occur off the western and southwestern parts of the water area.The maximum temperature and depth values of the GHSZ upper boundary are typical of the southeastern sea area and over the Kamchatka Peninsula slope.This study has also identified an area,where there are no thermobaric conditions for the emergence and stable existence of methane hydrates in the water column.The results presented agree well with the materials of observations conducted during expeditions and the previous data of predictive simulations for the Sea of Okhotsk.展开更多
Background Body weight is an important indicator of the overall health and production efficiency in broiler chickens.In broiler houses,body weight of chicks is variable despite the same genetics,hatching and feeding p...Background Body weight is an important indicator of the overall health and production efficiency in broiler chickens.In broiler houses,body weight of chicks is variable despite the same genetics,hatching and feeding practices within a production system.The objective of this study was to investigate the intestinal microbiota and bile salt hydrolase(BSH)activity in slow and fast growing broiler chickens,which belonged to the 10th and 90th percentile body weight groups,respectively.Methods A total of 300 Ross 308 broiler chickens(100 per cohort from three independent cohorts)were selected and mucosal samples from the jejunum,ileum,and cecum were collected at day of arrival,11 and 25(n=450).Then,bacterial counts,16S rRNA amplicon sequencing,species specific real-time qPCR,as well as BSH activity were analyzed.Results Results of bacterial counts showed no significant difference between slow and fast growing cohorts(P>0.05),but they tended to be higher in the slow growing chickens in all measured bacterial groups in cecum.The 16S rRNA amplicon sequencing revealed higher relative abundance of E.coli-Shigella(71.3%−79.8%)at day of arrival,while the most abundant microorganisms at d 25 was Candidatus Arthromitus(slow:44.5%;fast:27.4%)in small intestine.qPCR results indicated significant differences in bacterial populations between the slow and fast growing chickens,especially higher total bacteria,Enterococcus,and Clostridium cluster I in the slow growing chickens at d 25.BSH activity was higher in the slow growing chickens than the fast growing chickens[slow:0.476ΔOD/protein(μg/mL);fast:0.258ΔOD/protein(μg/mL);P<0.0001],and correlation analysis highlighted associations between BSH activity,body weight,feed intake,body weight gain,and bacterial counts.Conclusions We postulate that high total bacteria and Enterococcus abundance are associated with high BSH activity,impacting low feed intake and body weight gain,ultimately resulting in separation into slow and fast growing birds.The findings of this study contribute to understanding the relationship between gut microbiota,BSH activity,and host physiology in broiler chickens,with potential implications for poultry production.展开更多
This paper proposes a model-based control framework for vehicle platooning systems with secondorder nonlinear dynamics operating over switching signed networks,time-varying delays,and deception attacks.The study inclu...This paper proposes a model-based control framework for vehicle platooning systems with secondorder nonlinear dynamics operating over switching signed networks,time-varying delays,and deception attacks.The study includes two configurations:a leaderless structure using Finite-Time Non-Singular Terminal Bipartite Consensus(FNTBC)and Fixed-Time Bipartite Consensus(FXTBC),and a leader—follower structure ensuring structural balance and robustness against deceptive signals.In the leaderless model,a bipartite controller based on impulsive control theory,gauge transformation,and Markovian switching Lyapunov functions ensures mean-square stability and coordination under deception attacks and communication delays.The FNTBC achieves finite-time convergence depending on initial conditions,while the FXTBC guarantees fixed-time convergence independent of them,providing adaptability to different operating states.In the leader—follower case,a discontinuous impulsive control law synchronizes all followers with the leader despite deceptive attacks and switching topologies,maintaining robust coordination through nonlinear corrective mechanisms.To validate the approach,simulations are conducted on systems of five and seventeen vehicles in both leaderless and leader—follower configurations.The results demonstrate that the proposed framework achieves rapid consensus,strong robustness,and high resistance to deception attacks,offering a secure and scalable model-based control solution for modern vehicular communication networks.展开更多
How ecological and evolutionary factors affect small mammal diversity in arid regions remains largely unknown.Here,we combined the largest phylogeny and occurrence dataset of Gerbillinae desert rodents to explore the ...How ecological and evolutionary factors affect small mammal diversity in arid regions remains largely unknown.Here,we combined the largest phylogeny and occurrence dataset of Gerbillinae desert rodents to explore the underlying factors shaping present-day distribution patterns.In particular,we analyzed the relative contributions of ecological and evolutionary factors on their species diversity using a variety of models.Additionally,we inferred the ancestral range and possible dispersal scenarios and estimated the diversification rate of Gerbillinae.We found that Gerbillinae likely originated in the Horn of Africa in the Middle Miocene and then dispersed and diversified across arid regions in northern and southern Africa and western and central Asia,forming their current distribution pattern.Multiple ecological and evolutionary factors jointly determine the spatial pattern of Gerbillinae diversity,but evolutionary factors(evolutionary time and speciation rate)and habitat filtering were the most important in explaining the spatial variation in species richness.Our study enhances the understanding of the diversity patterns of small mammals in arid regions and highlights the importance of including evolutionary factors when interpreting the mechanisms underlying large-scale species diversity patterns.展开更多
Purpose: The primary aim of this study was to develop an assessment of the fundamental, combined, and complex movement skills required to support childhood physical literacy. The secondary aim was to establish the fea...Purpose: The primary aim of this study was to develop an assessment of the fundamental, combined, and complex movement skills required to support childhood physical literacy. The secondary aim was to establish the feasibility, objectivity, and reliability evidence for the assessment.Methods: An expert advisory group recommended a course format for the assessment that would require children to complete a series of dynamic movement skills. Criterion-referenced skill performance and completion time were the recommended forms of evaluation. Children, 8–12 years of age, self-reported their age and gender and then completed the study assessments while attending local schools or day camps. Face validity was previously established through a Delphi expert(n = 19, 21% female) review process. Convergent validity was evaluated by age and gender associations with assessment performance. Inter-and intra-rater(n = 53, 34% female) objectivity and test–retest(n = 60, 47% female) reliability were assessed through repeated test administration.Results: Median total score was 21 of 28 points(range 5–28). Median completion time was 17 s. Total scores were feasible for all 995 children who self-reported age and gender. Total score did not differ between inside and outside environments(95% confidence interval(CI) of difference:-0.7 to 0.6;p = 0.91) or with/without footwear(95%CI of difference:-2.5 to 1.9; p = 0.77). Older age(p < 0.001, η2= 0.15) and male gender(p < 0.001, η2= 0.02)were associated with a higher total score. Inter-rater objectivity evidence was excellent(intraclass correlation coefficient(ICC) = 0.99) for completion time and substantial for skill score(ICC = 0.69) for 104 attempts by 53 children(34% female). Intra-rater objectivity was moderate(ICC = 0.52) for skill score and excellent for completion time(ICC = 0.99). Reliability was excellent for completion time over a short(2–4 days; ICC = 0.84) or long(8–14days; ICC = 0.82) interval. Skill score reliability was moderate(ICC = 0.46) over a short interval, and substantial(ICC = 0.74) over a long interval.Conclusion: The Canadian Agility and Movement Skill Assessment is a feasible measure of selected fundamental, complex and combined movement skills, which are an important building block for childhood physical literacy. Moderate-to-excellent objectivity was demonstrated for children 8–12 years of age. Test–retest reliability has been established over an interval of at least 1 week. The time and skill scores can be accurately estimated by 1 trained examiner.展开更多
BACKGROUND Hematoma expansion(HE)typically portends a poor prognosis in spontaneous intracerebral hemorrhage(ICH).Several radiographic and laboratory values have been proposed as predictive markers of HE.AIM To perfor...BACKGROUND Hematoma expansion(HE)typically portends a poor prognosis in spontaneous intracerebral hemorrhage(ICH).Several radiographic and laboratory values have been proposed as predictive markers of HE.AIM To perform a systematic review and meta-analysis on the association of neu-trophil-to-lymphocyte ratio(NLR)and HE in ICH.A secondary outcome exa-mined was the association of NLR and perihematomal(PHE)growth.METHODS Three databases were searched(PubMed,EMBASE,and Cochrane)for studies evaluating the effect of NLR on HE and PHE growth.The inverse variance me-thod was applied to estimate an overall effect for each specific outcome by combining weighted averages of the individual studies’estimates of the logarithm odds ratio(OR).Given heterogeneity of the studies,a random effect was applied.Risk of bias was analyzed using the Newcastle-Ottawa Scale.The study was conducted following the Preferred Reporting Items for Systematic Review and Meta-analysis guidelines.The protocol was registered in PROSPERO(No.CRD42024549924).RESULTS Eleven retrospective cohort studies involving 2953 patients were included in the meta-analysis.Among those,HE was investigated in eight studies,whereas PHE growth was evaluated in three.Blood sample was obtained on admission in ten studies,and at 24 hours in one study.There was no consensus on cut-off value among the studies.NLR was found to be significantly associated with higher odds of HE(OR=1.09,95%CI:1.04-1.15,I2=86%,P<0.01),and PHE growth(OR=1.28,95%CI:1.19-1.38,I2=0%,P<0.01).Qualitative analysis of each outcome revealed overall moderate risk of bias mainly due to lack of control for systemic confounders.CONCLUSION The available literature suggests that a possible association may exist between NLR on admission and HE,and PHE growth.Future studies controlled for systemic confounders should be designed to consolidate this finding.If confirmed,NLR could be added as a readily available and inexpensive biomarker to identify a subgroup of patients at higher risk of developing HE.展开更多
Background Exogenous xylanase can increase utilization of fiber and energy when included in diets for pigs,and xylo-oligosaccharides(XOS)may improve growth performance of pigs by modulating intestinal fermentation.How...Background Exogenous xylanase can increase utilization of fiber and energy when included in diets for pigs,and xylo-oligosaccharides(XOS)may improve growth performance of pigs by modulating intestinal fermentation.However,it is unclear if a stimbiotic(i.e.,a combination of xylanase and XOS)has superior effects compared with a xylanase alone,and there is a lack of data demonstrating if xylanase fed to lactating sows influences growth performance of weanling pigs.Therefore,two hypotheses were tested:1)xylanase and stimbiotic improve growth performance,apparent total tract digestibility(ATTD)of gross energy(GE)and total dietary fiber(TDF),digestible energy(DE),and intestinal health of weanling pigs and 2)offspring of sows fed xylanase in lactation have greater growth performance after weaning than offspring of sows fed no xylanase during lactation.Methods One hundred and twenty pigs were weaned from sows fed a diet without xylanase,and 120 pigs were weaned from sows fed a lactation diet containing 16,000 beechwood xylanase units per kg(initial weight:5.81±0.50 kg).Pigs were allotted to a 2×3 factorial with two sow groups(lactation diet without or with xylanase)and three dietary treatments(i.e.,control,control plus xylanase,or control plus stimbiotic).Results There were no interactions between sow treatment and post-weaning pig treatment,and sow treatment did not impact post-weaning growth or ATTD of GE and TDF in weaned pigs.From d 15 to 28 post-weaning,the ADG,G:F,ATTD of GE and TDF,and concentration of DE were greater(P<0.05)for pigs fed the diet with stimbiotic than if fed the xylanase diet or the control diet,and pigs fed the xylanase diet had greater(P<0.05)ADG,G:F,ATTD of GE and TDF,and concentration of DE than pigs fed the control diet.From d 29 to 42 post-weaning,pigs fed the diets with xylanase or stimbiotic had greater(P<0.05)ADG,ATTD of GE and TDF,and DE than pigs fed the control diet.Conclusions Pigs fed xylanase or stimbiotic had greater ATTD of GE and TDF,greater DE,and greater overall ADG,G:F,and final body weight on d 42 post-weaning than pigs fed the control diet,but feeding sows xylanase in lactation did not influence post-weaning growth performance.展开更多
This paper provides a systematic review on the resilience analysis of active distribution networks(ADNs)against hazardous weather events,considering the underlying cyber-physical interdependencies.As cyber-physical sy...This paper provides a systematic review on the resilience analysis of active distribution networks(ADNs)against hazardous weather events,considering the underlying cyber-physical interdependencies.As cyber-physical systems,ADNs are characterized by widespread structural and functional interdependen-cies between cyber(communication,computing,and control)and physical(electric power)subsystems and thus present complex hazardous-weather-related resilience issues.To bridge current research gaps,this paper first classifies diverse hazardous weather events for ADNs according to different time spans and degrees of hazard,with model-based and data-driven methods being utilized to characterize weather evolutions.Then,the adverse impacts of hazardous weather on all aspects of ADNs’sources,physical/cyber networks,and loads are analyzed.This paper further emphasizes the importance of situational awareness and cyber-physical collaboration throughout hazardous weather events,as these enhance the implementation of preventive dispatches,corrective actions,and coordinated restorations.In addition,a generalized quantitative resilience evaluation process is proposed regarding additional considerations about cyber subsystems and cyber-physical connections.Finally,potential hazardous-weather-related resilience challenges for both physical and cyber subsystems are discussed.展开更多
Penile fracture is a rare clinical entity that occurs secondary to direct trauma to an erect penis,most commonly during sexual intercourse.Specifically,increased pressure within the corpus cavernosa results in rupture...Penile fracture is a rare clinical entity that occurs secondary to direct trauma to an erect penis,most commonly during sexual intercourse.Specifically,increased pressure within the corpus cavernosa results in rupture of the tunica albuginea.Occasionally,these injuries extend to the urethra and very rarely cause a complete urethral avulsion.Emergent exploration improves posttraumatic erectile function,penile curvature,and prevents painful erections.The traditional approach is a subcoronal circumcising incision to allow for adequate visualization.We present an uncircumcised male with bilateral corporal injuries and complete urethral avulsion who underwent a ventral midline approach for successful foreskin preservation.展开更多
Most wildfires are caused by human activities.Road networks play a dual role in wildfire dynamics,functioning either as potential ignition sources or as essential channels for suppression.This study focuses on roads a...Most wildfires are caused by human activities.Road networks play a dual role in wildfire dynamics,functioning either as potential ignition sources or as essential channels for suppression.This study focuses on roads as the link between human activity and the wildfire life cycle,identifying functional road elements and exploring design strategies for wildfire management.A literature review identified the relationship between roads and wildfires,and these insights were aligned with design elements through feature extraction from common geographical and infrastructural characteristics of affected areas.A qualitative and quantitative database was constructed for 225 wildfires in Korea from 2013 to 2022,each covering 2.5 ha or more.Cross-tabulation analysis demonstrated that wider roads have a mitigating effect on wildfire occurrence.Feature importance was further examined through Random Forest and Extra Trees regression,which identified significant variables associated with wildfire ignition.Based on the findings,several policy strategies were proposed.The results suggest that integrating road design elements into planning and upgrades can strengthen both wildfire prevention and suppression capacities.Moreover,the study highlights the need for greater policy attention to road infrastructure,given its substantial influence across the wildfire life cycle.展开更多
Soils play a critical role in the global carbon cycle, and can be major source or sink of CO2 depending upon land use, vegetation type and soil management practices. Fine roots are important component of a forest ecos...Soils play a critical role in the global carbon cycle, and can be major source or sink of CO2 depending upon land use, vegetation type and soil management practices. Fine roots are important component of a forest ecosystem in terms of water and nutrient uptake. In this study the effects of thinning and litter fall removal on fine root production and soil organic carbon content were examined in 20-year-old Masson pine （Pinus resinosa） plantations in Huitong, Hunan Province of China in the growing seasons of 2004 and 2005. The results showed that fine root production was significantly lower in the thinning plots than in the control plots, with a decrease of 58% and 14% in 2004 and 2005 growing seasons, respectively. Litter fall removal significantly increased fine root production by 14% in 2004. Soil temperature （Tsoil） and soil moisture （Msoil） were higher in the thinning plots than those in the controls. Litter fall removal had significant effects on Tsoil and Msoil. Soil organic carbon content was higher in the thinning plots but was lower in the plots with litter fall removal compared with that in the controls. Our results also indicated that annual production of fine roots resulted in small carbon accumulation in the upper layers of the soil, and removal of tree by thinning resulted in a significant increase of carbon storage in Masson pine plantations.展开更多
Filter pruning effectively compresses the neural network by reducing both its parameters and computational cost.Existing pruning methods typically rely on pre-designed pruning criteria to measure filter importance and...Filter pruning effectively compresses the neural network by reducing both its parameters and computational cost.Existing pruning methods typically rely on pre-designed pruning criteria to measure filter importance and remove those deemed unimportant.However,different layers of the neural network exhibit varying filter distributions,making it inappropriate to implement the same pruning criterion for all layers.Additionally,some approaches apply different criteria from the set of pre-defined pruning rules for different layers,but the limited space leads to the difficulty of covering all layers.If criteria for all layers are manually designed,it is costly and difficult to generalize to other networks.To solve this problem,we present a novel neural network pruning method based on the Criterion Learner and Attention Distillation(CLAD).Specifically,CLAD develops a differentiable criterion learner,which is integrated into each layer of the network.The learner can automatically learn the appropriate pruning criterion according to the filter parameters of each layer,thus the requirement of manual design is eliminated.Furthermore,the criterion learner is trained end-to-end by the gradient optimization algorithm to achieve efficient pruning.In addition,attention distillation,which fully utilizes the knowledge of unpruned networks to guide the optimization of the learner and improve the pruned network performance,is introduced in the process of learner optimization.Experiments conducted on various datasets and networks demonstrate the effectiveness of the proposed method.Notably,CLAD reduces the FLOPs of Res Net-110 by about 53%on the CIFAR-10 dataset,while simultaneously improves the network's accuracy by 0.05%.Moreover,it reduces the FLOPs of Res Net-50 by about 46%on the Image Net-1K dataset,and maintains a top-1 accuracy of 75.45%.展开更多
Primary biliary cholangitis(PBC)is a chronic autoimmune cholestatic liver disease characterized by progressive bile duct destruction,leading to fibrosis,cirrhosis,and eventual liver failure.Over the past two decades,s...Primary biliary cholangitis(PBC)is a chronic autoimmune cholestatic liver disease characterized by progressive bile duct destruction,leading to fibrosis,cirrhosis,and eventual liver failure.Over the past two decades,significant advancements have paved the way for novel therapeutic strategies.Ursodeoxycholic acid(UDCA)has been the cornerstone of PBC management,improving survival and delaying disease progression in most patients.However,up to 40%of patients demonstrate an inadequate response to UDCA,necessitating additional treatment options.Obeticholic acid(OCA),a farnesoid X receptor agonist,has emerged as a second-line therapy,showing efficacy in reducing alkaline phosphatase levels and improving liver biochemistry.Beyond UDCA and OCA,a new wave of therapeutic agents are reshaping the PBC landscape.These include fibrates,peroxisome proliferator-activated receptor agonists and novel immunomodulatory drugs aimed at reducing autoimmune-mediated liver injury.Bile acid transport inhibitors,anti-fibrotic agents,and gut microbiome-targeted therapies are also under investigation,offering hope for personalized treatment approaches.This review highlights the evolution of PBC therapy,emphasizing the unmet needs of patients with refractory disease and the potential of emerging therapies to improve outcomes.As the therapeutic landscape continues to expand,optimizing treatment strategies through precision medicine holds the promise of transforming the management of PBC.展开更多
Electric vehicles are pivotal in the global shift toward decarbonizing road transport,with lithium-ion batteries at the heart of this technological evolution.However,the pursuit of batteries capable of extremely fast ...Electric vehicles are pivotal in the global shift toward decarbonizing road transport,with lithium-ion batteries at the heart of this technological evolution.However,the pursuit of batteries capable of extremely fast charging that also satisfy high energy and safety criteria,poses a significant challenge to current lithium-ion batteries technologies.Additionally,the increasing demand for aluminum(Al)and copper(Cu)in electrification,solar energy technologies,and vehicle light-eighting is driving these metals toward near-critical status in the medium term.This study introduces metalized polythylene terephthalate(mPET)polymer films by depositing an Al or Cu thin layer onto two sides of a polyethylene terephthalate film—named mPET/Al and mPET/Cu,as lightweight,cost-effective alternatives to traditional metal current collectors in lithium-ion batteries.We have fabricated current collectors that significantly reduce weight(by 73%),thickness(by 33%),and cost(by 85%)compared with traditional metal foil counterparts.These advancements have the potential to enhance energy density to 280 Wh kg^(-1) at the electrode level under 10-min charging at 6 C.Through testing,including a novel extremely fast charging protocol across various C-rates and long-term cycling(up to 1000 cycles)in different cell configurations,the superior performance of these metalized polymer films has been demonstrated.Notably,mPET/Cu and mPET/Al films exhibited comparable capacities to conventional cells under extremely fast charging,with the mPET cells showing a 27%improvement in energy density at 6 C and maintaining significant energy density after 1000 cycles.This study underscores the potential of mPET films to revolutionize the roll-to-roll battery manufacturing process and significantly advance the performance metrics of lithium-ion batteries in electric vehicles applications.展开更多
BACKGROUND Percutaneous transhepatic gallbladder drainage has been the most frequently performed treatment for acute cholecystitis for patients who are not candidates for surgery.Endoscopic transpapillary gallbladder ...BACKGROUND Percutaneous transhepatic gallbladder drainage has been the most frequently performed treatment for acute cholecystitis for patients who are not candidates for surgery.Endoscopic transpapillary gallbladder drainage(ETGBD)has evolved into an alternative treatment.There have been numerous retrospective and prospective studies evaluating ETGBD for acute cholecystitis,though results have been variable.AIM To evaluate the efficacy and safety of ETGBD in the treatment of inoperable patients with acute cholecystitis.METHODS We performed a systematic review of major literature databases including PubMed,OVID,Science Direct,Google Scholar(from inception to March 2021)to identify studies reporting technical and clinical success,and post procedure adverse events in ETGBD.Weighted pooled rates were then calculated using fixed effects models for technical and clinical success,and post procedure adverse events,including recurrent cholecystitis.RESULTS We found 21 relevant articles that were then included in the study.In all 1307 patients were identified.The pooled technical success rate was 82.62%[95%confidence interval(CI):80.63-84.52].The pooled clinical success rate was found to be 94.87%(95%CI:93.54-96.05).The pooled overall complication rate was 8.83%(95%CI:7.42-10.34).Pooled rates of post procedure adverse events were bleeding 1.03%(95%CI:0.58-1.62),perforation 0.78%(95%CI:0.39-1.29),peritonitis/bile leak 0.45%(95%CI:0.17-0.87),and pancreatitis 1.98%(95%CI:1.33-2.76).The pooled rates of stent occlusion and migration were 0.39%(95%CI:0.13-0.78)and 1.3%(95%CI:0.75-1.99)respectively.The pooled rate of cholecystitis recurrence following ETGBD was 1.48%(95%CI:0.92-2.16).CONCLUSION Our meta-analysis suggests that ETGBD is a feasible and efficacious treatment for inoperable patients with acute cholecystitis.展开更多
基金supported by the National Research Foundation of Korea(NRF)funded by the Ministry of Science and ICT(MSIT),South Korea(RS-2024-00421181)financially supported in part by National R&D Program(2021M3H4A3A02086430)through NRF(National Research Foundation of Korea)funded by Ministry of Science and ICT+2 种基金the National Research Council of Science&Technology(NST)grant by the Korea government(MSIT)(No.GTL25021-210)The Inter-University Semiconductor Research Center,Institute of Engineering Research,and Soft Foundry Institute at Seoul National University provided research facilities for this workhe grant by the National Research Foundation of Korea(NSF)supported by the Korea government(MIST)(RS-2025-16903034)。
文摘As silicon-based transistors face fundamental scaling limits,the search for breakthrough alternatives has led to innovations in 3D architectures,heterogeneous integration,and sub-3 nm semiconductor body thicknesses.However,the true effectiveness of these advancements lies in the seamless integration of alternative semiconductors tailored for next-generation transistors.In this review,we highlight key advances that enhance both scalability and switching performance by leveraging emerging semiconductor materials.Among the most promising candidates are 2D van der Waals semiconductors,Mott insulators,and amorphous oxide semiconductors,which offer not only unique electrical properties but also low-power operation and high carrier mobility.Additionally,we explore the synergistic interactions between these novel semiconductors and advanced gate dielectrics,including high-K materials,ferroelectrics,and atomically thin hexagonal boron nitride layers.Beyond introducing these novel material configurations,we address critical challenges such as leakage current and long-term device reliability,which become increasingly crucial as transistors scale down to atomic dimensions.Through concrete examples showcasing the potential of these materials in transistors,we provide key insights into overcoming fundamental obstacles—such as device reliability,scaling down limitations,and extended applications in artificial intelligence—ultimately paving the way for the development of future transistor technologies.
基金supported by the National Natural Science Foundation of China(52272177,12204010)the Foundation for the Introduction of High-Level Talents of Anhui University(S020118002/097)+1 种基金the University Synergy Innovation Program of Anhui Province(GXXT-2023-066)the Scientific Research Project of Anhui Provincial Higher Education Institution(2023AH040008)。
文摘Flexible electronics face critical challenges in achieving monolithic three-dimensional(3D)integration,including material compatibility,structural stability,and scalable fabrication methods.Inspired by the tactile sensing mechanism of the human skin,we have developed a flexible monolithic 3D-integrated tactile sensing system based on a holey MXene paste,where each vertical one-body unit simultaneously functions as a microsupercapacitor and pressure sensor.The in-plane mesopores of MXene significantly improve ion accessibility,mitigate the self-stacking of nanosheets,and allow the holey MXene to multifunctionally act as a sensing material,an active electrode,and a conductive interconnect,thus drastically reducing the interface mismatch and enhancing the mechanical robustness.Furthermore,we fabricate a large-scale device using a blade-coating and stamping method,which demonstrates excellent mechanical flexibility,low-power consumption,rapid response,and stable long-term operation.As a proof-of-concept application,we integrate our sensing array into a smart access control system,leveraging deep learning to accurately identify users based on their unique pressing behaviors.This study provides a promising approach for designing highly integrated,intelligent,and flexible electronic systems for advanced human-computer interactions and personalized electronics.
文摘Protein aggregates,mitochondrial import stress and neurodegenerative disorders:A salient hallmark of several neurodegenerative diseases,including Parkinson’s disease,is the abundance of protein aggregates(Goiran et al.,2022).This molecular event is believed to lead to activation of stress pathways ultimately resulting in cellular dysfunction(Eldeeb et al.,2022).Accordingly,many lines of research investigations focused on dampening the formation of protein aggregates or augmenting the clearance of protein aggregates as a potential therapeutic strategy to counteract the progression of neurodegenerative diseases,albeit with little success(Costa-Mattioli and Walter,2020).Cell stress cues such as the accumulation of protein aggregates lead to the activation of stress response pathways that aid cells in responding to the damage.Despite the notion that the transient activation of these pathways helps cells cope with stressors,persistent activation can induce unwanted apoptosis of cells and reduce overall tissue strength as well as lead to an accumulation of aggregation-prone proteins(Hetz and Papa,2018).Mutations in proteins involved in stress signaling termination can cause conditions like ataxia and early-onset dementia(Conroy et al.,2014).Therefore,it is crucial for stress response signaling to be turned off once conditions have improved.Nevertheless,the mechanisms by which cells silence these signals are still elusive.
基金This study is financed by the European Union-NextGenerationEU,through the National Recovery and Resilience Plan of the Republic of Bulgaria,Project No.BG-RRP-2.013-0001.
文摘Covert timing channels(CTC)exploit network resources to establish hidden communication pathways,posing signi cant risks to data security and policy compliance.erefore,detecting such hidden and dangerous threats remains one of the security challenges. is paper proposes LinguTimeX,a new framework that combines natural language processing with arti cial intelligence,along with explainable Arti cial Intelligence(AI)not only to detect CTC but also to provide insights into the decision process.LinguTimeX performs multidimensional feature extraction by fusing linguistic attributes with temporal network patterns to identify covert channels precisely.LinguTimeX demonstrates strong e ectiveness in detecting CTC across multiple languages;namely English,Arabic,and Chinese.Speci cally,the LSTM and RNN models achieved F1 scores of 90%on the English dataset,89%on the Arabic dataset,and 88%on the Chinese dataset,showcasing their superior performance and ability to generalize across multiple languages. is highlights their robustness in detecting CTCs within security systems,regardless of the language or cultural context of the data.In contrast,the DeepForest model produced F1-scores ranging from 86%to 87%across the same datasets,further con rming its e ectiveness in CTC detection.Although other algorithms also showed reasonable accuracy,the LSTM and RNN models consistently outperformed them in multilingual settings,suggesting that deep learning models might be better suited for this particular problem.
文摘Objective Selective estrogen receptor modulators(SERMs)have demonstrated efficacy in the treatment of hypogonadism in males and male factor infertility.Two SERMs,clomiphene citrate and tamoxifen,are now prescribed for off-label use to treat both conditions in males.However,existing literature compares mixed protocols with active management.We aimed to conduct a meta-analysis to evaluate the effect of clomiphene and tamoxifen versus placebo on natural pregnancy rates.Methods We conducted a comprehensive systematic review of electronic databases:MEDLINE,PubMed/PMC,EMBASE,CINAHL,Cochrane Central Register of Controlled Trials(CENTRAL),Scopus,Google Scholar,and Web of Science.Articles satisfying all selection criteria were analyzed.The primary outcome was the incidence of pregnancy after receiving the treatment.Secondary outcomes included serum follicle-stimulating hormone,luteinizing hormone,and testosterone levels,and sperm count and motility.We calculated the pooled odds ratio,risk ratio,and risk difference to ascertain possible alterations in the direction of the pooled effect size.Results Ten randomized controlled trials were ultimately included and underwent data extraction.Clomiphene citrate and placebo groups had similar pregnancy rates(10.4%and 7.1%,respectively;odds ratio 1.30[95%confidence interval 0.27–6.17];p=0.74).No meta-analysis could be calculated for pregnancy rates in tamoxifen versus placebo groups.Heterogeneity among the studies of both SERMs ranged from low to high.Conclusion Although clomiphene citrate and tamoxifen are often used off-label for the treatment of male infertility secondary to hypogonadism,studies of SERMs in the treatment of idiopathic male factor infertility are limited and heterogenous,preventing this meta-analysis from investigating the efficacy of SERMs on male infertility.The effect of clomiphene citrate or tamoxifen on the pregnancy rate remains uncertain.
基金the POI FEB RAS,entitled“Study of the Structure and Dynamics of World’s Oceans Waters in Conditions of Current Climate Change”(reg.no.124022100079-4).
文摘This study was used oceanographic database in the Sea of Okhotsk between the period from 1929 to 2020(131286 stations).The paper used gas hydrate dissociation parameters for the“pure methane-seawater”system obtained in the study by Dickens GR and Quinby-Hunt MS.The results have elucidated the spatiotemporal variability of distribution of such parameters at the upper boundary of the gas hydrate stability zone(GHSZ)as water temperature,salinity,and top depth of the stability zone.As the study has shown(based on average long-term spatial distributions),the minimum temperature and depth values of the GHSZ upper boundary in the Sea of Okhotsk occur off the western and southwestern parts of the water area.The maximum temperature and depth values of the GHSZ upper boundary are typical of the southeastern sea area and over the Kamchatka Peninsula slope.This study has also identified an area,where there are no thermobaric conditions for the emergence and stable existence of methane hydrates in the water column.The results presented agree well with the materials of observations conducted during expeditions and the previous data of predictive simulations for the Sea of Okhotsk.
基金supported by research funding provided by Arm&Hammer Animal and Food Production,Waukesha,WI 53186,USA.
文摘Background Body weight is an important indicator of the overall health and production efficiency in broiler chickens.In broiler houses,body weight of chicks is variable despite the same genetics,hatching and feeding practices within a production system.The objective of this study was to investigate the intestinal microbiota and bile salt hydrolase(BSH)activity in slow and fast growing broiler chickens,which belonged to the 10th and 90th percentile body weight groups,respectively.Methods A total of 300 Ross 308 broiler chickens(100 per cohort from three independent cohorts)were selected and mucosal samples from the jejunum,ileum,and cecum were collected at day of arrival,11 and 25(n=450).Then,bacterial counts,16S rRNA amplicon sequencing,species specific real-time qPCR,as well as BSH activity were analyzed.Results Results of bacterial counts showed no significant difference between slow and fast growing cohorts(P>0.05),but they tended to be higher in the slow growing chickens in all measured bacterial groups in cecum.The 16S rRNA amplicon sequencing revealed higher relative abundance of E.coli-Shigella(71.3%−79.8%)at day of arrival,while the most abundant microorganisms at d 25 was Candidatus Arthromitus(slow:44.5%;fast:27.4%)in small intestine.qPCR results indicated significant differences in bacterial populations between the slow and fast growing chickens,especially higher total bacteria,Enterococcus,and Clostridium cluster I in the slow growing chickens at d 25.BSH activity was higher in the slow growing chickens than the fast growing chickens[slow:0.476ΔOD/protein(μg/mL);fast:0.258ΔOD/protein(μg/mL);P<0.0001],and correlation analysis highlighted associations between BSH activity,body weight,feed intake,body weight gain,and bacterial counts.Conclusions We postulate that high total bacteria and Enterococcus abundance are associated with high BSH activity,impacting low feed intake and body weight gain,ultimately resulting in separation into slow and fast growing birds.The findings of this study contribute to understanding the relationship between gut microbiota,BSH activity,and host physiology in broiler chickens,with potential implications for poultry production.
基金Deanship of Research and Graduate Studies at King Khalid University for funding this work through Large Research Project under grant number RGP.2/103/46”Deanship of Scientific Research at Northern Border University,Arar,Saudi Arabia for funding this research work through project number“NBU-FFR-2025-871-15”funding from Prince Sattam bin Abdulaziz University project number(PSAU/2025/R/1447).
文摘This paper proposes a model-based control framework for vehicle platooning systems with secondorder nonlinear dynamics operating over switching signed networks,time-varying delays,and deception attacks.The study includes two configurations:a leaderless structure using Finite-Time Non-Singular Terminal Bipartite Consensus(FNTBC)and Fixed-Time Bipartite Consensus(FXTBC),and a leader—follower structure ensuring structural balance and robustness against deceptive signals.In the leaderless model,a bipartite controller based on impulsive control theory,gauge transformation,and Markovian switching Lyapunov functions ensures mean-square stability and coordination under deception attacks and communication delays.The FNTBC achieves finite-time convergence depending on initial conditions,while the FXTBC guarantees fixed-time convergence independent of them,providing adaptability to different operating states.In the leader—follower case,a discontinuous impulsive control law synchronizes all followers with the leader despite deceptive attacks and switching topologies,maintaining robust coordination through nonlinear corrective mechanisms.To validate the approach,simulations are conducted on systems of five and seventeen vehicles in both leaderless and leader—follower configurations.The results demonstrate that the proposed framework achieves rapid consensus,strong robustness,and high resistance to deception attacks,offering a secure and scalable model-based control solution for modern vehicular communication networks.
基金supported by grants from the Third Xinjiang Scientific Expedition Program(Grant No.2022xjkk0205 to Lin Xia,No.2021xjkk0604 to Jilong Cheng)the National Natural Science Foundation of China(32170416 to Qisen Yang,31900325 to Jilong Cheng)+1 种基金the Joint Fund of National Natural Science Foundation of China(U2003203 to Lin Xia)the Key Laboratory of Zoological Systematics and Evolution of the Chinese Academy of Sciences(Y229YX5105 to Qisen Yang).
文摘How ecological and evolutionary factors affect small mammal diversity in arid regions remains largely unknown.Here,we combined the largest phylogeny and occurrence dataset of Gerbillinae desert rodents to explore the underlying factors shaping present-day distribution patterns.In particular,we analyzed the relative contributions of ecological and evolutionary factors on their species diversity using a variety of models.Additionally,we inferred the ancestral range and possible dispersal scenarios and estimated the diversification rate of Gerbillinae.We found that Gerbillinae likely originated in the Horn of Africa in the Middle Miocene and then dispersed and diversified across arid regions in northern and southern Africa and western and central Asia,forming their current distribution pattern.Multiple ecological and evolutionary factors jointly determine the spatial pattern of Gerbillinae diversity,but evolutionary factors(evolutionary time and speciation rate)and habitat filtering were the most important in explaining the spatial variation in species richness.Our study enhances the understanding of the diversity patterns of small mammals in arid regions and highlights the importance of including evolutionary factors when interpreting the mechanisms underlying large-scale species diversity patterns.
基金funded by a grant from the Canadian Institutes of Health Research awarded to Dr. Meghann Lloyd and Dr. Mark Tremblay (IHD 94356)
文摘Purpose: The primary aim of this study was to develop an assessment of the fundamental, combined, and complex movement skills required to support childhood physical literacy. The secondary aim was to establish the feasibility, objectivity, and reliability evidence for the assessment.Methods: An expert advisory group recommended a course format for the assessment that would require children to complete a series of dynamic movement skills. Criterion-referenced skill performance and completion time were the recommended forms of evaluation. Children, 8–12 years of age, self-reported their age and gender and then completed the study assessments while attending local schools or day camps. Face validity was previously established through a Delphi expert(n = 19, 21% female) review process. Convergent validity was evaluated by age and gender associations with assessment performance. Inter-and intra-rater(n = 53, 34% female) objectivity and test–retest(n = 60, 47% female) reliability were assessed through repeated test administration.Results: Median total score was 21 of 28 points(range 5–28). Median completion time was 17 s. Total scores were feasible for all 995 children who self-reported age and gender. Total score did not differ between inside and outside environments(95% confidence interval(CI) of difference:-0.7 to 0.6;p = 0.91) or with/without footwear(95%CI of difference:-2.5 to 1.9; p = 0.77). Older age(p < 0.001, η2= 0.15) and male gender(p < 0.001, η2= 0.02)were associated with a higher total score. Inter-rater objectivity evidence was excellent(intraclass correlation coefficient(ICC) = 0.99) for completion time and substantial for skill score(ICC = 0.69) for 104 attempts by 53 children(34% female). Intra-rater objectivity was moderate(ICC = 0.52) for skill score and excellent for completion time(ICC = 0.99). Reliability was excellent for completion time over a short(2–4 days; ICC = 0.84) or long(8–14days; ICC = 0.82) interval. Skill score reliability was moderate(ICC = 0.46) over a short interval, and substantial(ICC = 0.74) over a long interval.Conclusion: The Canadian Agility and Movement Skill Assessment is a feasible measure of selected fundamental, complex and combined movement skills, which are an important building block for childhood physical literacy. Moderate-to-excellent objectivity was demonstrated for children 8–12 years of age. Test–retest reliability has been established over an interval of at least 1 week. The time and skill scores can be accurately estimated by 1 trained examiner.
文摘BACKGROUND Hematoma expansion(HE)typically portends a poor prognosis in spontaneous intracerebral hemorrhage(ICH).Several radiographic and laboratory values have been proposed as predictive markers of HE.AIM To perform a systematic review and meta-analysis on the association of neu-trophil-to-lymphocyte ratio(NLR)and HE in ICH.A secondary outcome exa-mined was the association of NLR and perihematomal(PHE)growth.METHODS Three databases were searched(PubMed,EMBASE,and Cochrane)for studies evaluating the effect of NLR on HE and PHE growth.The inverse variance me-thod was applied to estimate an overall effect for each specific outcome by combining weighted averages of the individual studies’estimates of the logarithm odds ratio(OR).Given heterogeneity of the studies,a random effect was applied.Risk of bias was analyzed using the Newcastle-Ottawa Scale.The study was conducted following the Preferred Reporting Items for Systematic Review and Meta-analysis guidelines.The protocol was registered in PROSPERO(No.CRD42024549924).RESULTS Eleven retrospective cohort studies involving 2953 patients were included in the meta-analysis.Among those,HE was investigated in eight studies,whereas PHE growth was evaluated in three.Blood sample was obtained on admission in ten studies,and at 24 hours in one study.There was no consensus on cut-off value among the studies.NLR was found to be significantly associated with higher odds of HE(OR=1.09,95%CI:1.04-1.15,I2=86%,P<0.01),and PHE growth(OR=1.28,95%CI:1.19-1.38,I2=0%,P<0.01).Qualitative analysis of each outcome revealed overall moderate risk of bias mainly due to lack of control for systemic confounders.CONCLUSION The available literature suggests that a possible association may exist between NLR on admission and HE,and PHE growth.Future studies controlled for systemic confounders should be designed to consolidate this finding.If confirmed,NLR could be added as a readily available and inexpensive biomarker to identify a subgroup of patients at higher risk of developing HE.
基金financial support for this research by AB Vista,Marlborough,UK,is greatly appreciated.
文摘Background Exogenous xylanase can increase utilization of fiber and energy when included in diets for pigs,and xylo-oligosaccharides(XOS)may improve growth performance of pigs by modulating intestinal fermentation.However,it is unclear if a stimbiotic(i.e.,a combination of xylanase and XOS)has superior effects compared with a xylanase alone,and there is a lack of data demonstrating if xylanase fed to lactating sows influences growth performance of weanling pigs.Therefore,two hypotheses were tested:1)xylanase and stimbiotic improve growth performance,apparent total tract digestibility(ATTD)of gross energy(GE)and total dietary fiber(TDF),digestible energy(DE),and intestinal health of weanling pigs and 2)offspring of sows fed xylanase in lactation have greater growth performance after weaning than offspring of sows fed no xylanase during lactation.Methods One hundred and twenty pigs were weaned from sows fed a diet without xylanase,and 120 pigs were weaned from sows fed a lactation diet containing 16,000 beechwood xylanase units per kg(initial weight:5.81±0.50 kg).Pigs were allotted to a 2×3 factorial with two sow groups(lactation diet without or with xylanase)and three dietary treatments(i.e.,control,control plus xylanase,or control plus stimbiotic).Results There were no interactions between sow treatment and post-weaning pig treatment,and sow treatment did not impact post-weaning growth or ATTD of GE and TDF in weaned pigs.From d 15 to 28 post-weaning,the ADG,G:F,ATTD of GE and TDF,and concentration of DE were greater(P<0.05)for pigs fed the diet with stimbiotic than if fed the xylanase diet or the control diet,and pigs fed the xylanase diet had greater(P<0.05)ADG,G:F,ATTD of GE and TDF,and concentration of DE than pigs fed the control diet.From d 29 to 42 post-weaning,pigs fed the diets with xylanase or stimbiotic had greater(P<0.05)ADG,ATTD of GE and TDF,and DE than pigs fed the control diet.Conclusions Pigs fed xylanase or stimbiotic had greater ATTD of GE and TDF,greater DE,and greater overall ADG,G:F,and final body weight on d 42 post-weaning than pigs fed the control diet,but feeding sows xylanase in lactation did not influence post-weaning growth performance.
基金supported by the National Natural Science Foundation of China(52477132 and U2066601).
文摘This paper provides a systematic review on the resilience analysis of active distribution networks(ADNs)against hazardous weather events,considering the underlying cyber-physical interdependencies.As cyber-physical systems,ADNs are characterized by widespread structural and functional interdependen-cies between cyber(communication,computing,and control)and physical(electric power)subsystems and thus present complex hazardous-weather-related resilience issues.To bridge current research gaps,this paper first classifies diverse hazardous weather events for ADNs according to different time spans and degrees of hazard,with model-based and data-driven methods being utilized to characterize weather evolutions.Then,the adverse impacts of hazardous weather on all aspects of ADNs’sources,physical/cyber networks,and loads are analyzed.This paper further emphasizes the importance of situational awareness and cyber-physical collaboration throughout hazardous weather events,as these enhance the implementation of preventive dispatches,corrective actions,and coordinated restorations.In addition,a generalized quantitative resilience evaluation process is proposed regarding additional considerations about cyber subsystems and cyber-physical connections.Finally,potential hazardous-weather-related resilience challenges for both physical and cyber subsystems are discussed.
文摘Penile fracture is a rare clinical entity that occurs secondary to direct trauma to an erect penis,most commonly during sexual intercourse.Specifically,increased pressure within the corpus cavernosa results in rupture of the tunica albuginea.Occasionally,these injuries extend to the urethra and very rarely cause a complete urethral avulsion.Emergent exploration improves posttraumatic erectile function,penile curvature,and prevents painful erections.The traditional approach is a subcoronal circumcising incision to allow for adequate visualization.We present an uncircumcised male with bilateral corporal injuries and complete urethral avulsion who underwent a ventral midline approach for successful foreskin preservation.
文摘Most wildfires are caused by human activities.Road networks play a dual role in wildfire dynamics,functioning either as potential ignition sources or as essential channels for suppression.This study focuses on roads as the link between human activity and the wildfire life cycle,identifying functional road elements and exploring design strategies for wildfire management.A literature review identified the relationship between roads and wildfires,and these insights were aligned with design elements through feature extraction from common geographical and infrastructural characteristics of affected areas.A qualitative and quantitative database was constructed for 225 wildfires in Korea from 2013 to 2022,each covering 2.5 ha or more.Cross-tabulation analysis demonstrated that wider roads have a mitigating effect on wildfire occurrence.Feature importance was further examined through Random Forest and Extra Trees regression,which identified significant variables associated with wildfire ignition.Based on the findings,several policy strategies were proposed.The results suggest that integrating road design elements into planning and upgrades can strengthen both wildfire prevention and suppression capacities.Moreover,the study highlights the need for greater policy attention to road infrastructure,given its substantial influence across the wildfire life cycle.
基金Supported by the "948" Grant of the National Forestry Administration of China (No.2007-4-19)the Special Grantof Chinese Forestry Public Benefits (Nos.200804030 and 2007-4-15)the Provincial Fund for Distinguished Young Scholars of Hunan, China (No.07JJ1004)
文摘Soils play a critical role in the global carbon cycle, and can be major source or sink of CO2 depending upon land use, vegetation type and soil management practices. Fine roots are important component of a forest ecosystem in terms of water and nutrient uptake. In this study the effects of thinning and litter fall removal on fine root production and soil organic carbon content were examined in 20-year-old Masson pine （Pinus resinosa） plantations in Huitong, Hunan Province of China in the growing seasons of 2004 and 2005. The results showed that fine root production was significantly lower in the thinning plots than in the control plots, with a decrease of 58% and 14% in 2004 and 2005 growing seasons, respectively. Litter fall removal significantly increased fine root production by 14% in 2004. Soil temperature （Tsoil） and soil moisture （Msoil） were higher in the thinning plots than those in the controls. Litter fall removal had significant effects on Tsoil and Msoil. Soil organic carbon content was higher in the thinning plots but was lower in the plots with litter fall removal compared with that in the controls. Our results also indicated that annual production of fine roots resulted in small carbon accumulation in the upper layers of the soil, and removal of tree by thinning resulted in a significant increase of carbon storage in Masson pine plantations.
基金supported in part by the National Natural Science Foundation of China under grants 62073085,61973330 and 62350055in part by the Shenzhen Science and Technology Program,China under grant JCYJ20230807093513027in part by the Fundamental Research Funds for the Central Universities,China under grant 1243300008。
文摘Filter pruning effectively compresses the neural network by reducing both its parameters and computational cost.Existing pruning methods typically rely on pre-designed pruning criteria to measure filter importance and remove those deemed unimportant.However,different layers of the neural network exhibit varying filter distributions,making it inappropriate to implement the same pruning criterion for all layers.Additionally,some approaches apply different criteria from the set of pre-defined pruning rules for different layers,but the limited space leads to the difficulty of covering all layers.If criteria for all layers are manually designed,it is costly and difficult to generalize to other networks.To solve this problem,we present a novel neural network pruning method based on the Criterion Learner and Attention Distillation(CLAD).Specifically,CLAD develops a differentiable criterion learner,which is integrated into each layer of the network.The learner can automatically learn the appropriate pruning criterion according to the filter parameters of each layer,thus the requirement of manual design is eliminated.Furthermore,the criterion learner is trained end-to-end by the gradient optimization algorithm to achieve efficient pruning.In addition,attention distillation,which fully utilizes the knowledge of unpruned networks to guide the optimization of the learner and improve the pruned network performance,is introduced in the process of learner optimization.Experiments conducted on various datasets and networks demonstrate the effectiveness of the proposed method.Notably,CLAD reduces the FLOPs of Res Net-110 by about 53%on the CIFAR-10 dataset,while simultaneously improves the network's accuracy by 0.05%.Moreover,it reduces the FLOPs of Res Net-50 by about 46%on the Image Net-1K dataset,and maintains a top-1 accuracy of 75.45%.
文摘Primary biliary cholangitis(PBC)is a chronic autoimmune cholestatic liver disease characterized by progressive bile duct destruction,leading to fibrosis,cirrhosis,and eventual liver failure.Over the past two decades,significant advancements have paved the way for novel therapeutic strategies.Ursodeoxycholic acid(UDCA)has been the cornerstone of PBC management,improving survival and delaying disease progression in most patients.However,up to 40%of patients demonstrate an inadequate response to UDCA,necessitating additional treatment options.Obeticholic acid(OCA),a farnesoid X receptor agonist,has emerged as a second-line therapy,showing efficacy in reducing alkaline phosphatase levels and improving liver biochemistry.Beyond UDCA and OCA,a new wave of therapeutic agents are reshaping the PBC landscape.These include fibrates,peroxisome proliferator-activated receptor agonists and novel immunomodulatory drugs aimed at reducing autoimmune-mediated liver injury.Bile acid transport inhibitors,anti-fibrotic agents,and gut microbiome-targeted therapies are also under investigation,offering hope for personalized treatment approaches.This review highlights the evolution of PBC therapy,emphasizing the unmet needs of patients with refractory disease and the potential of emerging therapies to improve outcomes.As the therapeutic landscape continues to expand,optimizing treatment strategies through precision medicine holds the promise of transforming the management of PBC.
文摘Electric vehicles are pivotal in the global shift toward decarbonizing road transport,with lithium-ion batteries at the heart of this technological evolution.However,the pursuit of batteries capable of extremely fast charging that also satisfy high energy and safety criteria,poses a significant challenge to current lithium-ion batteries technologies.Additionally,the increasing demand for aluminum(Al)and copper(Cu)in electrification,solar energy technologies,and vehicle light-eighting is driving these metals toward near-critical status in the medium term.This study introduces metalized polythylene terephthalate(mPET)polymer films by depositing an Al or Cu thin layer onto two sides of a polyethylene terephthalate film—named mPET/Al and mPET/Cu,as lightweight,cost-effective alternatives to traditional metal current collectors in lithium-ion batteries.We have fabricated current collectors that significantly reduce weight(by 73%),thickness(by 33%),and cost(by 85%)compared with traditional metal foil counterparts.These advancements have the potential to enhance energy density to 280 Wh kg^(-1) at the electrode level under 10-min charging at 6 C.Through testing,including a novel extremely fast charging protocol across various C-rates and long-term cycling(up to 1000 cycles)in different cell configurations,the superior performance of these metalized polymer films has been demonstrated.Notably,mPET/Cu and mPET/Al films exhibited comparable capacities to conventional cells under extremely fast charging,with the mPET cells showing a 27%improvement in energy density at 6 C and maintaining significant energy density after 1000 cycles.This study underscores the potential of mPET films to revolutionize the roll-to-roll battery manufacturing process and significantly advance the performance metrics of lithium-ion batteries in electric vehicles applications.
文摘BACKGROUND Percutaneous transhepatic gallbladder drainage has been the most frequently performed treatment for acute cholecystitis for patients who are not candidates for surgery.Endoscopic transpapillary gallbladder drainage(ETGBD)has evolved into an alternative treatment.There have been numerous retrospective and prospective studies evaluating ETGBD for acute cholecystitis,though results have been variable.AIM To evaluate the efficacy and safety of ETGBD in the treatment of inoperable patients with acute cholecystitis.METHODS We performed a systematic review of major literature databases including PubMed,OVID,Science Direct,Google Scholar(from inception to March 2021)to identify studies reporting technical and clinical success,and post procedure adverse events in ETGBD.Weighted pooled rates were then calculated using fixed effects models for technical and clinical success,and post procedure adverse events,including recurrent cholecystitis.RESULTS We found 21 relevant articles that were then included in the study.In all 1307 patients were identified.The pooled technical success rate was 82.62%[95%confidence interval(CI):80.63-84.52].The pooled clinical success rate was found to be 94.87%(95%CI:93.54-96.05).The pooled overall complication rate was 8.83%(95%CI:7.42-10.34).Pooled rates of post procedure adverse events were bleeding 1.03%(95%CI:0.58-1.62),perforation 0.78%(95%CI:0.39-1.29),peritonitis/bile leak 0.45%(95%CI:0.17-0.87),and pancreatitis 1.98%(95%CI:1.33-2.76).The pooled rates of stent occlusion and migration were 0.39%(95%CI:0.13-0.78)and 1.3%(95%CI:0.75-1.99)respectively.The pooled rate of cholecystitis recurrence following ETGBD was 1.48%(95%CI:0.92-2.16).CONCLUSION Our meta-analysis suggests that ETGBD is a feasible and efficacious treatment for inoperable patients with acute cholecystitis.
