AIM: To determine whether online diffusion of the "Ten Warning Signs of Primary Immunodeficiency Diseases(PID)'' adheres to accepted scientific standards.METHODS: We analyzed how reproducible is online di...AIM: To determine whether online diffusion of the "Ten Warning Signs of Primary Immunodeficiency Diseases(PID)'' adheres to accepted scientific standards.METHODS: We analyzed how reproducible is online diffusion of a unique instrument, the "Ten Warning Signs of PID", created by the Jeffrey Modell Foundation(JMF),by Google-assisted searches among highly visited sites from professional, academic and scientific organizations;governmental agencies; and patient support/advocacy organizations. We examined the diffusion, consistency of use and adequate referencing of this instrument.Where applicable, variant versions of the instrument were examined for changes in factual content that would have practical impact on physicians or on patients and their families.RESULTS: Among the first 100 sites identified by Google search, 85 faithfully reproduced the JMF model, and correctly referenced to its source. By contrast, the other15 also referenced the JMF source but presented one or more changes in content relative to their purported model and therefore represent uncontrolled variants, of unknown origin. Discrepancies identified in the latter included changes in factual content of the original JMF list(C), as well as removal(R) and introduction(I) of novel signs(Table 2), all made without reference to any scientific publications that might account for the drastic changes in factual content. Factual changes include changes inthe number of infectious episodes considered necessary to raise suspicion of PID, as well as the inclusion of various medical conditions not mentioned in the original.Together, these changes will affect the way physicians use the instrument to consult or to inform patients,and the way patients and families think about the need for specialist consultation in view of a possible PID diagnosis.CONCLUSION: The retrieved adaptations and variants,which significantly depart from the original instrument,raise concerns about standards for scientific information provided online to physicians, patients and families.展开更多
Accurate classification of encrypted traffic plays an important role in network management.However,current methods confronts several problems:inability to characterize traffic that exhibits great dispersion,inability ...Accurate classification of encrypted traffic plays an important role in network management.However,current methods confronts several problems:inability to characterize traffic that exhibits great dispersion,inability to classify traffic with multi-level features,and degradation due to limited training traffic size.To address these problems,this paper proposes a traffic granularity-based cryptographic traffic classification method,called Granular Classifier(GC).In this paper,a novel Cardinality-based Constrained Fuzzy C-Means(CCFCM)clustering algorithm is proposed to address the problem caused by limited training traffic,considering the ratio of cardinality that must be linked between flows to achieve good traffic partitioning.Then,an original representation format of traffic is presented based on granular computing,named Traffic Granules(TG),to accurately describe traffic structure by catching the dispersion of different traffic features.Each granule is a compact set of similar data with a refined boundary by excluding outliers.Based on TG,GC is constructed to perform traffic classification based on multi-level features.The performance of the GC is evaluated based on real-world encrypted network traffic data.Experimental results show that the GC achieves outstanding performance for encrypted traffic classification with limited size of training traffic and keeps accurate classification in dynamic network conditions.展开更多
本文介绍了采用无格点Kinetic Monte Carlo(KMC)方法,模拟TiN薄膜在TiN(001)基底表面上外延生长的仿真结果。在此无格点KMC方法中,使用了Dimer算法在势能面中搜索鞍点和低能盆底。仿真的结果证实,此无格点KMC方法对于仿真二元薄膜外延...本文介绍了采用无格点Kinetic Monte Carlo(KMC)方法,模拟TiN薄膜在TiN(001)基底表面上外延生长的仿真结果。在此无格点KMC方法中,使用了Dimer算法在势能面中搜索鞍点和低能盆底。仿真的结果证实,此无格点KMC方法对于仿真二元薄膜外延生长是有效的。本文中还讨论了无格点KMC的计算量问题、运算过程中Dimer的初始位置问题和势能面中浅盆底问题。展开更多
Reservoir engineering is the term used in quantum control and information technologies to describe manipulating the environment within which an open quantum system operates. Reservoir engineering is essential in appli...Reservoir engineering is the term used in quantum control and information technologies to describe manipulating the environment within which an open quantum system operates. Reservoir engineering is essential in applications where storing quantum information is required. From the control theory perspective, a quantum system is capable of storing quantum information if it possesses a so-called decoherence free subsystem （DFS）. This paper explores pole placement techniques to facilitate synthesis of decoherence free subsystems via coherent quantum feedback control. We discuss limitations of the conventional ＇open loop＇ approach and propose a constructive feedback design methodology for decoherence free subsystem engineering. It captures a quite general dynamic coherent feedback structure which allows systems with decoherence free modes to be synthesized from components which do not have such modes.展开更多
In order to identify potential wood substitutes for the production of energy by gasification, binary blends （wood/miscanthus, miscanthus/straw and wood/straw） and ternary blends （wood, miscanthus and organic residu...In order to identify potential wood substitutes for the production of energy by gasification, binary blends （wood/miscanthus, miscanthus/straw and wood/straw） and ternary blends （wood, miscanthus and organic residue） were systematic tested in a laboratory bubbling fluidized bed gasification system. The results of experiments were compared with results of wood gasification. Of the binary blends, wood and miscanthus exhibited great potential as a wood substitute in fluidized bed gasification in terms of process stability and product gas quality. Adding 10 wt. % of organic residues to form ternary blends further improved the product gas quality. Gasification of fuels blended with straw tended to agglomerate in the fluidized bed because of straw＇s low ash melting temperature. This can be counteracted by adding Ca（OH）2 to fuels. Nonetheless, fuels blended with straw with higher percentages of Ca（OH）2 need further study to establish the optimal additive ratio.展开更多
The increase in chronic diseases in childhood highlights the need for a biopsychosocial approach to deal with the complexity of these health conditions. The International Classification of Functioning, Disability, and...The increase in chronic diseases in childhood highlights the need for a biopsychosocial approach to deal with the complexity of these health conditions. The International Classification of Functioning, Disability, and Health (ICF) results from the need to implement new explanatory evaluative and therapeutic models. Thus, the present systematic review aims to identify published studies on the use of the ICF in chronic childhood diseases. As a secondary objective, to map the themes that have already been studied in the area to support the discussion on the expansion of the use of this classification in health services. The systematic review followed the PRISMA protocol, and the model was the PICO acronym, where Population was children and adolescents with chronic diseases, Intervention/Exposure was evaluation based on ICF concepts, Comparator was any tool, instrument, or intervention, and outcome was direct or indirect use of the ICF. We selected eight articles, five of which used the ICF as a conceptual tool and three as a classification system, divided into the following themes: quality of life, evaluation of patients (without using coding) and mapping the inclusion of the activity’s results and participation in clinical trials. Thus, use of the ICF in clinical practice is still incipient, although it has been recommended in guidelines. Further studies are necessary to expand the number of contributions by the ICF and to develop the necessary approaches for understanding the classification’s use.展开更多
文摘AIM: To determine whether online diffusion of the "Ten Warning Signs of Primary Immunodeficiency Diseases(PID)'' adheres to accepted scientific standards.METHODS: We analyzed how reproducible is online diffusion of a unique instrument, the "Ten Warning Signs of PID", created by the Jeffrey Modell Foundation(JMF),by Google-assisted searches among highly visited sites from professional, academic and scientific organizations;governmental agencies; and patient support/advocacy organizations. We examined the diffusion, consistency of use and adequate referencing of this instrument.Where applicable, variant versions of the instrument were examined for changes in factual content that would have practical impact on physicians or on patients and their families.RESULTS: Among the first 100 sites identified by Google search, 85 faithfully reproduced the JMF model, and correctly referenced to its source. By contrast, the other15 also referenced the JMF source but presented one or more changes in content relative to their purported model and therefore represent uncontrolled variants, of unknown origin. Discrepancies identified in the latter included changes in factual content of the original JMF list(C), as well as removal(R) and introduction(I) of novel signs(Table 2), all made without reference to any scientific publications that might account for the drastic changes in factual content. Factual changes include changes inthe number of infectious episodes considered necessary to raise suspicion of PID, as well as the inclusion of various medical conditions not mentioned in the original.Together, these changes will affect the way physicians use the instrument to consult or to inform patients,and the way patients and families think about the need for specialist consultation in view of a possible PID diagnosis.CONCLUSION: The retrieved adaptations and variants,which significantly depart from the original instrument,raise concerns about standards for scientific information provided online to physicians, patients and families.
基金supported in part by the Shandong Provincial Natural Science Foundation under Grant ZR2021QF008the National Natural Science Foundation of China under Grant 62072351+1 种基金in part by the open research project of ZheJiang Lab under grant 2021PD0AB01in part by the 111 Project under Grant B16037。
文摘Accurate classification of encrypted traffic plays an important role in network management.However,current methods confronts several problems:inability to characterize traffic that exhibits great dispersion,inability to classify traffic with multi-level features,and degradation due to limited training traffic size.To address these problems,this paper proposes a traffic granularity-based cryptographic traffic classification method,called Granular Classifier(GC).In this paper,a novel Cardinality-based Constrained Fuzzy C-Means(CCFCM)clustering algorithm is proposed to address the problem caused by limited training traffic,considering the ratio of cardinality that must be linked between flows to achieve good traffic partitioning.Then,an original representation format of traffic is presented based on granular computing,named Traffic Granules(TG),to accurately describe traffic structure by catching the dispersion of different traffic features.Each granule is a compact set of similar data with a refined boundary by excluding outliers.Based on TG,GC is constructed to perform traffic classification based on multi-level features.The performance of the GC is evaluated based on real-world encrypted network traffic data.Experimental results show that the GC achieves outstanding performance for encrypted traffic classification with limited size of training traffic and keeps accurate classification in dynamic network conditions.
文摘本文介绍了采用无格点Kinetic Monte Carlo(KMC)方法,模拟TiN薄膜在TiN(001)基底表面上外延生长的仿真结果。在此无格点KMC方法中,使用了Dimer算法在势能面中搜索鞍点和低能盆底。仿真的结果证实,此无格点KMC方法对于仿真二元薄膜外延生长是有效的。本文中还讨论了无格点KMC的计算量问题、运算过程中Dimer的初始位置问题和势能面中浅盆底问题。
文摘Reservoir engineering is the term used in quantum control and information technologies to describe manipulating the environment within which an open quantum system operates. Reservoir engineering is essential in applications where storing quantum information is required. From the control theory perspective, a quantum system is capable of storing quantum information if it possesses a so-called decoherence free subsystem （DFS）. This paper explores pole placement techniques to facilitate synthesis of decoherence free subsystems via coherent quantum feedback control. We discuss limitations of the conventional ＇open loop＇ approach and propose a constructive feedback design methodology for decoherence free subsystem engineering. It captures a quite general dynamic coherent feedback structure which allows systems with decoherence free modes to be synthesized from components which do not have such modes.
文摘In order to identify potential wood substitutes for the production of energy by gasification, binary blends （wood/miscanthus, miscanthus/straw and wood/straw） and ternary blends （wood, miscanthus and organic residue） were systematic tested in a laboratory bubbling fluidized bed gasification system. The results of experiments were compared with results of wood gasification. Of the binary blends, wood and miscanthus exhibited great potential as a wood substitute in fluidized bed gasification in terms of process stability and product gas quality. Adding 10 wt. % of organic residues to form ternary blends further improved the product gas quality. Gasification of fuels blended with straw tended to agglomerate in the fluidized bed because of straw＇s low ash melting temperature. This can be counteracted by adding Ca（OH）2 to fuels. Nonetheless, fuels blended with straw with higher percentages of Ca（OH）2 need further study to establish the optimal additive ratio.
文摘The increase in chronic diseases in childhood highlights the need for a biopsychosocial approach to deal with the complexity of these health conditions. The International Classification of Functioning, Disability, and Health (ICF) results from the need to implement new explanatory evaluative and therapeutic models. Thus, the present systematic review aims to identify published studies on the use of the ICF in chronic childhood diseases. As a secondary objective, to map the themes that have already been studied in the area to support the discussion on the expansion of the use of this classification in health services. The systematic review followed the PRISMA protocol, and the model was the PICO acronym, where Population was children and adolescents with chronic diseases, Intervention/Exposure was evaluation based on ICF concepts, Comparator was any tool, instrument, or intervention, and outcome was direct or indirect use of the ICF. We selected eight articles, five of which used the ICF as a conceptual tool and three as a classification system, divided into the following themes: quality of life, evaluation of patients (without using coding) and mapping the inclusion of the activity’s results and participation in clinical trials. Thus, use of the ICF in clinical practice is still incipient, although it has been recommended in guidelines. Further studies are necessary to expand the number of contributions by the ICF and to develop the necessary approaches for understanding the classification’s use.
