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Cerebrospinal fluid as a therapeutic medium for magnetic nanoparticle transport in brain cancer hyperthermia
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作者 Essam T Abdelwahab Ahmed A Elsawy +1 位作者 Abdallah A Henedy Sara I Abdelsalam 《Chinese Physics B》 2026年第2期475-490,共16页
Neuronanomedicine is a promising interdisciplinary field combining two critical fields,neuroscience and nanotechnology.This study focuses on the engineering of magnetized nanoparticles(MNPs)in diagnosing and treating ... Neuronanomedicine is a promising interdisciplinary field combining two critical fields,neuroscience and nanotechnology.This study focuses on the engineering of magnetized nanoparticles(MNPs)in diagnosing and treating neurological disorders and brain cancer.Additionally,this mechanism enhances the effectiveness of magnetic-guided drug delivery.The alternating magnetic field is applied to control the directions of the MNPs to target the tumor cells.This study approaches the radiotherapy techniques of magnetic hyperthermia therapy(MHT),wherein the thermal radiative heat transfer effect is applied to achieve homogenous heating to destroy cancer cells.MNPs are injected through the cerebrospinal fluid(CSF)transport in the glymphatic system.The elastic properties of the cerebral arteries cause peristaltic propulsion for the resulting nanofluid.Therefore,the effective Maxwell model for the nanofluid thermal conductivity is selected.The nanofluid governing equations are solved using the perturbation technique under small wavelength number and long wavelength approximation with small Reynolds number.Additionally,the effects of thermal slip and elastic properties boundary conditions are incorporated.The graphical results for the streamwise velocity,pressure,and temperature distributions are plotted using MATLAB package considering the different effects of the magnetic flux intensity,thermal radiation parameter,thermal slipping at boundaries,elastic wall properties,and nanoparticle concentration.The results demonstrate the strong impact of the magnetic field and radiation heating in terms of enhancing the nanofluid CSF flow behavior and destroying cancer. 展开更多
关键词 peristaltic flow thermal radiation magnetic field NANOFLUID perturbation technique
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Benchmarking the composite performance of distinct shapes of ferrometallic gold nanoshells:photothermal cancer therapy 被引量:1
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作者 Sara I.Abdelsalam Essam T.Abdelwahab +2 位作者 I.M.Eldesoky Ramzy M.Abumandour M.M.Ahmed 《Acta Mechanica Sinica》 2025年第6期3-15,共13页
This article presents a detailed theoretical hybrid analysis of the magnetism and the thermal radiative heat transfer in the presence of heat generation affecting the behavior of the dispersed gold nanoparticles(AuNPs... This article presents a detailed theoretical hybrid analysis of the magnetism and the thermal radiative heat transfer in the presence of heat generation affecting the behavior of the dispersed gold nanoparticles(AuNPs)through the blood vessels of the human body.The rheology of gold-blood nanofluid is treated as magnetohydrodynamic(MHD)flow with ferromagnetic properties.The AuNPs take different shapes as bricks,cylinders,and platelets which are considered in changing the nanofluid flow behavior.Physiologically,the blood is circulated under the kinetics of the peristaltic action.The mixed properties of the slip flow,the gravity,the space porosity,the transverse ferromagnetic field,the thermal radiation,the nanoparticles shape factors,the peristaltic amplitude ratio,and the concentration of the AuNPs are interacted and analyzed for the gold-blood circulation in the inclined tube.The appropriate model for the thermal conductivity of the nanofluid is chosen to be the effective Hamilton-Crosser model.The undertaken nanofluid can be treated as incompressible non-Newtonian ferromagnetic fluid.The solutions of the partial differential governing equations of the MHD nanofluid flow are executed by the strategy of perturbation approach under the assumption of long wavelength and low Reynolds number.Graphs for the streamwise velocity distributions,temperature distributions,pressure gradients,pressure drops,and streamlines are presented under the influences of the pertinent properties.The practical implementation of this research finds application in treating cancer through a technique known as photothermal therapy(PTT).The results indicate the control role of the magnetism,the heat generation,the shape factors of the AuNPs,and its concentration on the enhancement of the thermal properties and the streamwise velocity of the nanofluid.The results reveal a marked enhancement in the temperature profiles of the nanofluid,prominently influenced by both the intensified heat source and the heightened volume fractions of the nanoparticles.Furthermore,the platelet shape is regarded as most advantageous for heat conduction owing to its highest effective thermal conductivity.AuNPs proved strong efficiency in delivering and targeting the drug to reach the affected area with tumors.These results offer valuable insights into evaluating the effectiveness of PTT in addressing diverse cancer conditions and regulating their progression. 展开更多
关键词 Peristaltic flow NANOFLUID AuNPs MAGNETISM Shape factor Gravity Heat transfer Porous medium
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Numerical Simulation via Homotopy Perturbation Approach of a Dissipative Squeezed Carreau Fluid Flow Due to a Sensor Surface
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作者 Sara I.Abdelsalam W.Abbas +2 位作者 Ahmed M.Megahed Hassan M.H.Sadek M.S.Emam 《Frontiers in Heat and Mass Transfer》 2025年第5期1511-1527,共17页
This study rigorously examines the interplay between viscous dissipation,magnetic effects,and thermal radiation on the flow behavior of a non-Newtonian Carreau squeezed fluid passing by a sensor surface within a micro... This study rigorously examines the interplay between viscous dissipation,magnetic effects,and thermal radiation on the flow behavior of a non-Newtonian Carreau squeezed fluid passing by a sensor surface within a micro cantilever channel,aiming to deepen our understanding of heat transport processes in complex fluid dynamics scenarios.The primary objective is to elucidate how physical operational parameters influence both the velocity of fluid flow and its temperature distribution,utilizing a comprehensive numerical approach.Employing a combination of mathematical modeling techniques,including similarity transformation,this investigation transforms complex partial differential equations into more manageable ordinary ones,subsequently solving them using the homotopy perturbation method.By analyzing the obtained solutions and presenting them graphically,alongside detailed analysis,the study sheds light on the pivotal role of significant parameters in shaping fluid movement and energy distribution.Noteworthy observations reveal a substantial increase in fluid velocity with escalating magnetic parameters,while conversely,a contrasting trend emerges in the temperature distribution,highlighting the intricate relationship between magnetic effects,flow dynamics,and thermal behavior in non-Newtonian fluids.Further,the suction velocity enhance both the local skin friction and Nusselt numbers,whereas theWeissenberg number reduces them,opposite to the effect of the power-law index. 展开更多
关键词 Homotopy perturbation method squeezed flow Carreau fluid sensor surface magnetic field viscous dissipation
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Artificial neural network validation of MHD natural bioconvection in a square enclosure:entropic analysis and optimization
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作者 Noura Alsedais Mohamed Ahmed Mansour +1 位作者 Abdelraheem Mahmoud Aly Sara I.Abdelsalam 《Acta Mechanica Sinica》 2025年第9期17-35,共19页
This study numerically investigates inclined magneto-hydrodynamic natural convection in a porous cavity filled with nanofluid containing gyrotactic microorganisms.The governing equations are nondimensionalized and sol... This study numerically investigates inclined magneto-hydrodynamic natural convection in a porous cavity filled with nanofluid containing gyrotactic microorganisms.The governing equations are nondimensionalized and solved using the finite volume method.The simulations examine the impact of key parameters such as heat source length and position,Peclet number,porosity,and heat generation/absorption on flow patterns,temperature distribution,concentration profiles,and microorganism rotation.Results indicate that extending the heat source length enhances convective currents and heat transfer efficiency,while optimizing the heat source position reduces entropy generation.Higher Peclet numbers amplify convective currents and microorganism distribution complexity.Variations in porosity and heat generation/absorption significantly influence flow dynamics.Additionally,the artificial neural network model reliably predicts the mean Nusselt and Sherwood numbers(Nu&Sh),demonstrating its effectiveness for such analyses.The simulation results reveal that increasing the heat source length significantly enhances heat transfer,as evidenced by a 15%increase in the mean Nusselt number. 展开更多
关键词 Artificial neural network Gyrotactic microorganisms MAGNETOHYDRODYNAMICS Natural convection Square enclosure
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Semi Analytical Solution of MHD and Heat Transfer of Couple Stress Fluid over a Stretching Sheet with Radiation in Porous Medium
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作者 Sara I.Abdelsalam M.Khairy +2 位作者 W.Abbas Ahmed M.Megahed M.S.Emam 《Frontiers in Heat and Mass Transfer》 2025年第6期1833-1846,共14页
This comprehensive research examines the dynamics of magnetohydrodynamic(MHD)flow and heat transfer within a couple stress fluid.The investigation specifically focuses on the fluid’s behavior over a vertical stretchi... This comprehensive research examines the dynamics of magnetohydrodynamic(MHD)flow and heat transfer within a couple stress fluid.The investigation specifically focuses on the fluid’s behavior over a vertical stretching sheet embedded within a porous medium,providing valuable insights into the complex interactions between fluid mechanics,thermal transport,and magnetic fields.This study accounts for the significant impact of heat generation and thermal radiation,crucial factors for enhancing heat transfer efficiency in various industrial and technological contexts.The research employs mathematical techniques to simplify complex partial differential equations(PDEs)governing fluid flow and heat transfer.Specifically,suitable similarity transformations are applied to convert the PDEs into a more manageable system of ordinary differential equations(ODEs).The homotopy perturbation method(HPM)is employed to derive approximate analytical solutions for the problem.The influences of key parameters,such as magnetic field strength,heat generation,thermal radiation,porosity,and couple stress,on velocity and temperature profiles are analyzed and discussed.Findings indicate that the mixed convection parameter positively affects flow velocity,while the magnetic field parameter significantly alters the flow dynamics,exhibiting an inverse relationship.Further,this type of flow behavior model is relevant to real-world systems like cooling of nuclear reactors and oil extraction through porous formations,where magnetic and thermal effects are significant. 展开更多
关键词 Couple stress fluid HPM MHD non-newtonian fluid heat transfer stretched sheet thermal radiation
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Biomimetic amelioration of zirconium nanoparticles on a rigid substrate over viscous slime--a physiological approach 被引量:1
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作者 S.I.ABDELSALAM A.Z.ZAHER 《Applied Mathematics and Mechanics(English Edition)》 SCIE EI CSCD 2023年第9期1563-1576,共14页
In this article,an investigation is conducted to study the precise role of zirconium nanoparticles that exist in a slime-like fluid subject to specific adjustments.Since gliding is a technique of mobility used by bact... In this article,an investigation is conducted to study the precise role of zirconium nanoparticles that exist in a slime-like fluid subject to specific adjustments.Since gliding is a technique of mobility used by bacteria that lack motility components,bacteria travel on their own strength in gliding locomotion by secreting a layer of slime on the substrate.A model of an undulating sheet over a layer of slime of a Rabinowitsch fluid is investigated as a potential model of bacteria’s gliding motility.With the aid of long wavelength approximation,the equations governing the circulation of slime underneath the cells are established and analytically solved.The effects of pseudoplasticity,dilatation and non-Newtonian parameter on the behavior of zirconium concentration,speed of microorganism(bacteria),streamline patterns,and pressure rise for non-Newtonian and Newtonian fluids are compared.The power required for propulsion is also investigated.Physical interpretation for the pertinent variables has been graphically discussed against the parameters under consideration.It is found that with the increase in the concentration of zirconium nanoparticles,the bacterial flow is accelerated and attains its maximum near the rigid substrate wall while an opposite behavior is noticed in the rest region. 展开更多
关键词 zirconium nanoparticle gliding bacterium Grashof heat transfer glider's speed Rabinowitsch fluid
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Geometrodynamical Analysis to Characterize the Dynamics and Stability of a Molecular System through the Boundary of the Hill’s Region
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作者 Alberto Vergel Rosa M. Benito +1 位作者 Juan C. Losada Florentino Borondo 《Applied Mathematics》 2014年第16期2630-2642,共13页
In this paper we study the dynamics and stability of a two-dimensional model for the vibrations of the LiCN molecule making use of the Riemannian geometry via the Jacobi-Levi-Civita equations applied to the Jacobi met... In this paper we study the dynamics and stability of a two-dimensional model for the vibrations of the LiCN molecule making use of the Riemannian geometry via the Jacobi-Levi-Civita equations applied to the Jacobi metric. The Stability Geometrical Indicator for short times is calculated to locate regular and chaotic trajectories as the relative extrema of this indicator. Only trajectories with initial conditions at the boundary of the Hill’s region are considered to characterize the dynamics of the system. The importance of the curvature of this boundary for the stability of trajectories bouncing on it is also discussed. 展开更多
关键词 Geometrodynamical Analysis MOLECULAR Nonlinear DYNAMICS STABILITY Geometrical Indicator RIEMANNIAN Geometry HAMILTONIAN Systems
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Artificial Intelligence-Driven FVM-ANNModel for Entropy Analysis ofMHD Natural Bioconvection in Nanofluid-Filled Porous Cavities
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作者 Noura Alsedais Mohamed Ahmed Mansour +1 位作者 Abdelraheem M.Aly Sara I.Abdelsalam 《Frontiers in Heat and Mass Transfer》 EI 2024年第5期1277-1307,共31页
The research examines fluid behavior in a porous box-shaped enclosure.The fluid contains nanoscale particles and swimming microbes and is subject to magnetic forces at an angle.Natural circulation driven by biological... The research examines fluid behavior in a porous box-shaped enclosure.The fluid contains nanoscale particles and swimming microbes and is subject to magnetic forces at an angle.Natural circulation driven by biological factors is investigated.The analysis combines a traditional numerical approach with machine learning techniques.Mathematical equations describing the system are transformed into a dimensionless form and then solved using computational methods.The artificial neural network(ANN)model,trained with the Levenberg-Marquardt method,accurately predicts(Nu)values,showing high correlation(R=1),low mean squared error(MSE),and minimal error clustering.Parametric analysis reveals significant effects of parameters,length and location of source(B),(D),heat generation/absorption coefficient(Q),and porosity parameter(ε).Increasing the cooling area length(B)reduces streamline intensity and local Nusselt and Sherwood numbers,while decreasing isotherms,isoconcentrations,and micro-rotation.The Bejan number(Be+)decreases with increasing(B),whereas(Be+++),and global entropy(e+++)increase.Variations in(Q)slightly affect streamlines but reduce isotherm intensity and average Nusselt numbers.Higher(D)significantly impacts isotherms,iso-concentrations,andmicro-rotation,altering streamline contours and local Bejan number distribution.Increased(ε)enhances streamline strength and local Nusselt number profiles but has mixed effects on average Nusselt numbers.These findings highlight the complex interactions between cooling area length,fluid flow,and heat transfer properties.By combining finite volume method(FVM)with machine learning technique,this study provides valuable insights into the complex interactions between key parameters and heat transfer,contributing to the development of more efficient designs in applications such as cooling systems,energy storage,and bioengineering. 展开更多
关键词 ANN model finite volume method natural bioconvection flow magnetohydrodynamics(MHD) porous media
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Towards understanding thermal management in unsteady boundary layer flow with AC/DC electric fields
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作者 Sara I.Abdelsalam Mohamed A.Dagher +1 位作者 Y.Abd Elmaboud A.I.Abdellateef 《Propulsion and Power Research》 2025年第1期64-75,共12页
Unsteady boundary layer flow induced by alternating current(AC)or direct current(DC)electric field through a porous layer is investigated numerically.The finite difference method based on Crank-Nicolson is applied to ... Unsteady boundary layer flow induced by alternating current(AC)or direct current(DC)electric field through a porous layer is investigated numerically.The finite difference method based on Crank-Nicolson is applied to solve the nonlinear system.The governing equations are built with fractional shear stress and the Cattaneo heat flux model,and time fractional derivatives are computed using the Caputo fractional derivative.The numerical results are presented to demonstrate the effects of varying parameters on momentum and thermal boundary layer.The results reveal that the time delay in the velocity profile occurs for larger values of both the velocity fractional derivative parameter and the velocity relaxation time due to the molecules colliding and interacting,thereby exchanging momentum to achieve a new equilibrium.Additionally,factors such as permeability,magnetic field strength(Hartmann number),Grashof number,and Biot number are shown to significantly influence fluid movement,heat convection,and temperature gradients within the boundary layer.This insight is of paramount importance in engineering applications such as enhanced oil recovery,geothermal reservoir management,and advanced cooling systems,where precise control of fluid dynamics and heat transfer is essential for optimizing performance and resource utilization. 展开更多
关键词 AC/DC electric field Fractional shear stress Cattaneo heat flux model Caputo fractional derivative Boundary layer
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1966年Fields奖,2004年Abel奖得主Atiyah爵士访谈录
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作者 Oscar Garcia-Prada 黄雷(译) 龚雪飞(校) 《数学译林》 2019年第3期213-225,共13页
Michael Atiyah(阿蒂亚)和他的合作者改变了近几十年的数学面貌.在他的工作中,人们可以在诸多其他基础性工作外,单独看到在理论物理中有重要应用的指标定理(与Isadore Singer(辛格)合作)和对Yang-Mills(杨振宁-米尔斯)方程的几何研究.... Michael Atiyah(阿蒂亚)和他的合作者改变了近几十年的数学面貌.在他的工作中,人们可以在诸多其他基础性工作外,单独看到在理论物理中有重要应用的指标定理(与Isadore Singer(辛格)合作)和对Yang-Mills(杨振宁-米尔斯)方程的几何研究.他的贡献极好地显示了数学的统一性,特别是几何学和物理学相互影响的重要性.他是对科学界在相关学科的工作有巨大影响的关键人物.在获得了其他诸多奖项外,他被授予1966年的Fields(菲尔兹)奖,1988年的Copley奖和2004年的Abel(阿贝尔)奖.他也是建立欧洲数学会的推动者之一. 展开更多
关键词 理论物理 阿贝尔 杨振宁 相关学科 几何学 物理学 关键人物 阿蒂亚
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The combinatorics of Green's functions in planar field theories
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作者 Kurusch Ebrahimi-Fard Frederic Patras 《Frontiers of physics》 SCIE CSCD 2016年第6期1-23,共23页
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