In the context of the era of carbon peaking and carbon neutrality,clarifying the emission patterns of non-CO_(2)Greenhouse Gas(GHG)from agricultural sources is of practical significance to China’s implementation of g...In the context of the era of carbon peaking and carbon neutrality,clarifying the emission patterns of non-CO_(2)Greenhouse Gas(GHG)from agricultural sources is of practical significance to China’s implementation of greenhouse gas emission reduction policies.The Intergovernmental Panel on Climate Change(IPCC)coefficient method was used to calculate non-CO_(2)GHG emissions from agricultural sources in 122 counties in Hunan Province,China,from 2010 to 2020,and the spatiotemporal evolution characteristics of emission intensity were analyzed.The Stochastic Impacts by Regression on Population,Affluence,and Technology(STRIPAT)model forecasted the prospective evolution of non-CO_(2)GHG emissions from agricultural sources at the county level under various scenarios from 2030 to 2050.The results demonstrated a general decline in non-CO_(2)GHG emissions from agricultural sources within the study area,with 75.41%of counties exhibiting a reduction in emissions.Geographically,emissions were higher in the Dongting Lake area and central Hengyang.The emission intensity per unit of agricultural added value and the intensity per unit of agricultural land area showed an overall downward trend.Spatially,the emission intensity per unit of farmland area in a few counties(cities,districts)in southern Hunan was still relatively high.By forecasting the non-CO_(2)GHG emissions from agricultural sources,the majority of counties(cities and districts)demonstrated a gradual decline in emissions,suggesting that agricultural production had the potential to reduce emissions in the future,while also facing certain pressure to reduce emissions.It is recommended that Hunan Province formulate agricultural carbon emission reduction policies that take regional development differences into account.This would provide a reference for future agricultural carbon emission reduction research in the whole country.展开更多
This longitudinal study investigated how self-management and learning burnout influences the relationship between habitual mobile phone use and subjective well-being amongfirst-year university students.A sample of 1172 ...This longitudinal study investigated how self-management and learning burnout influences the relationship between habitual mobile phone use and subjective well-being amongfirst-year university students.A sample of 1172 Chinese university students participated in a two-wave survey,with data collected six months apart at two time points(T1,T2).The results of Pearson correlation revealed that higher habitual mobile phone use at T1 was associated with lower subjective well-being at T2.Self-management was associated with healthy phone use habits and higher subjective wellbeing.Learning burnout risk was higher with habitual phone usage.Lower self-management and learning burnout at T2 played a chain mediating role between habitual mobile phone use at T1 and subjective well-being at T2 so that subjective well-being was much lower that with either of the variables alone.Overall,thesefindings suggest that habitual mobile phone use is a reliable predictor of college student’s subjective well-being,by their self-management and level of learning burnout over time.This research highlights the long-term impact of habitual mobile phone use on students’subjective well-being and provides valuable insights for developing effective interventions to support students well-being.展开更多
The integration of cloud computing into traditional industrial control systems is accelerating the evolution of Industrial Cyber-Physical System(ICPS),enhancing intelligence and autonomy.However,this transition also e...The integration of cloud computing into traditional industrial control systems is accelerating the evolution of Industrial Cyber-Physical System(ICPS),enhancing intelligence and autonomy.However,this transition also expands the attack surface,introducing critical security vulnerabilities.To address these challenges,this article proposes a hybrid intrusion detection scheme for securing ICPSs that combines system state anomaly and network traffic anomaly detection.Specifically,an improved variation-Bayesian-based noise covariance-adaptive nonlinear Kalman filtering(IVB-NCA-NLKF)method is developed to model nonlinear system dynamics,enabling optimal state estimation in multi-sensor ICPS environments.Intrusions within the physical sensing system are identified by analyzing residual discrepancies between predicted and observed system states.Simultaneously,an adaptive network traffic anomaly detection mechanism is introduced,leveraging learned traffic patterns to detect node-and network-level anomalies through pattern matching.Extensive experiments on a simulated network control system demonstrate that the proposed framework achieves higher detection accuracy(92.14%)with a reduced false alarm rate(0.81%).Moreover,it not only detects known attacks and vulnerabilities but also uncovers stealthy attacks that induce system state deviations,providing a robust and comprehensive security solution for the safety protection of ICPS.展开更多
The ubiquity of mobile devices has driven advancements in mobile object detection.However,challenges in multi-scale object detection in open,complex environments persist due to limited computational resources.Traditio...The ubiquity of mobile devices has driven advancements in mobile object detection.However,challenges in multi-scale object detection in open,complex environments persist due to limited computational resources.Traditional approaches like network compression,quantization,and lightweight design often sacrifice accuracy or feature representation robustness.This article introduces the Fast Multi-scale Channel Shuffling Network(FMCSNet),a novel lightweight detection model optimized for mobile devices.FMCSNet integrates a fully convolutional Multilayer Perceptron(MLP)module,offering global perception without significantly increasing parameters,effectively bridging the gap between CNNs and Vision Transformers.FMCSNet achieves a delicate balance between computation and accuracy mainly by two key modules:the ShiftMLP module,including a shift operation and an MLP module,and a Partial group Convolutional(PGConv)module,reducing computation while enhancing information exchange between channels.With a computational complexity of 1.4G FLOPs and 1.3M parameters,FMCSNet outperforms CNN-based and DWConv-based ShuffleNetv2 by 1%and 4.5%mAP on the Pascal VOC 2007 dataset,respectively.Additionally,FMCSNet achieves a mAP of 30.0(0.5:0.95 IoU threshold)with only 2.5G FLOPs and 2.0M parameters.It achieves 32 FPS on low-performance i5-series CPUs,meeting real-time detection requirements.The versatility of the PGConv module’s adaptability across scenarios further highlights FMCSNet as a promising solution for real-time mobile object detection.展开更多
Background:Glioblastoma(GBM)prognosis has seen little improvement over the past two decades.While immunotherapy has revolutionized cancer treatment,its impact on GBM remains limited.To characterize the evolving resear...Background:Glioblastoma(GBM)prognosis has seen little improvement over the past two decades.While immunotherapy has revolutionized cancer treatment,its impact on GBM remains limited.To characterize the evolving research landscape and identify future directions in GBM immunotherapy,we conducted a comprehensive bibliometric review.Methods:All literature related to immunotherapy in GBM from 1999 to 2024 was collected from the Web of Science Core Collection.CtieSpace and VOSviewer were used to conduct bibliometric analysis and visualize the data.Results:Bibliometric analysis identified 5038 publications authored by 23,335 researchers from 4699 institutions across 96 countries/regions,published in 945 journals.The United States produced the highest number of publications,while Switzerland achieved the highest average citation rate.Duke University led in institutional output and citations.John H Sampson was the most productive author,and Roger Stupp was the most cited.Frontiers in Immunology published the most papers,while Clinical Cancer Research was the most cited journal.Research focus centered on adoptive T cell therapy,particularly chimeric antigen receptor(CAR)-T cells with 572 dedicated publications.Within CAR-T research for GBM,the University of Pennsylvania was the leading institution,Frontiers in Immunology the predominant journal,and Christine E Brown(City of Hope National Medical Center)was the most prolific and cited author.Conclusions:There has been a growing interest in GBM immunotherapy over past decades.The United States is the dominant contributor.CAR-T therapy represents the primary research focus.Emerging strategies like chimeric antigen receptor-modified natural killer(CAR-NK)cells,chimeric antigen receptor-engineered macrophages(CAR-M),and cytomegalovirus-specific T cell receptor(CMV-TCR)T cells are gaining prominence,aiming to address limitations in antigen recognition inherent to CAR-T therapy for GBM.展开更多
A new species of Megophrys (Amphibia: Anura: Megophryidae), Megophrys tuberogranulatus Shen, Mo et Li, sp.nov. (Holotype HNUL 03080902, adult male, SVL: 38.2 mm), from Sangzhi County, Hunan Province, is described. Meg...A new species of Megophrys (Amphibia: Anura: Megophryidae), Megophrys tuberogranulatus Shen, Mo et Li, sp.nov. (Holotype HNUL 03080902, adult male, SVL: 38.2 mm), from Sangzhi County, Hunan Province, is described. Megophrystuberogranulatus is closely related to both Megophrys kuatunensis and Megophrys minor. Characters of the new species that differentiatethis species from close relatives are skin granulated with big tubercles on the dorsal sides of both thigh and tibia, thebigger inner metacarpal tubercle, upper eyelid wider than the interorbital space, hind limbs longer, overlapping of the left andright calcaneal parts. The type specimens are deposited in the Animal Museum of Life Sciences College of Hunan Normal University.展开更多
A new species of the genus Tylototriton is described in this article based on morphological and genetic evidence. The new species is identified belonging to the T. asperrimus group and is similar to T. wenxianensis. T...A new species of the genus Tylototriton is described in this article based on morphological and genetic evidence. The new species is identified belonging to the T. asperrimus group and is similar to T. wenxianensis. The diagnostic characters of the new species are as follows: dorsal ridge broad and thick,its width approximately equal to eye diameter(P < 0.001); tail height greater than width at base of tail(P < 0.001); no villous genital papilla found inside the male anal fissure; nodule-like warts,along lateral margin of the trunk,bulge and forming tubercles,and thin and transverse striae present between the tubercles.展开更多
In high intensity focused ultrasound(HIFU)treatment,it is crucial to accurately identify denatured and normal biological tissues.In this paper,a novel method based on compressed sensing(CS)and refined composite multi-...In high intensity focused ultrasound(HIFU)treatment,it is crucial to accurately identify denatured and normal biological tissues.In this paper,a novel method based on compressed sensing(CS)and refined composite multi-scale fuzzy entropy(RCMFE)is proposed.First,CS is used to denoise the HIFU echo signals.Then the multi-scale fuzzy entropy(MFE)and RCMFE of the denoised HIFU echo signals are calculated.This study analyzed 90 cases of HIFU echo signals,including 45 cases in normal status and 45 cases in denatured status,and the results show that although both MFE and RCMFE can be used to identify denatured tissues,the intra-class distance of RCMFE on each scale factor is smaller than MFE,and the inter-class distance is larger than MFE.Compared with MFE,RCMFE can calculate the complexity of the signal more accurately and improve the stability,compactness,and separability.When RCMFE is selected as the characteristic parameter,the RCMFE difference between denatured and normal biological tissues is more evident than that of MFE,which helps doctors evaluate the treatment effect more accurately.When the scale factor is selected as 16,the best distinguishing effect can be obtained.展开更多
In order to understand the status of fixed ammonium, fixed ammonium content, maximum capacity of ammonium fixation, and their influencing factors in major types of tillage soils of Hunan Province, China, were studied ...In order to understand the status of fixed ammonium, fixed ammonium content, maximum capacity of ammonium fixation, and their influencing factors in major types of tillage soils of Hunan Province, China, were studied with sampling on fields, and laboratory incubation and determination. The main results are summarized as follows： （1） Content of fixed ammonium in the tested soils varies greatly with soil use pattern and the nature of parent material. For the paddy soils, it ranges from 135.4 ± 57.4 to 412.8±32,4 mg kg^-1, with 304.7±96.7 mg kg^-1 in average; while it ranges from 59.4 to 435.7 mg kg^-1, with 230.1 ± 89.2 mg kg^-1 in average for the upland soils. The soils developed from limnic material and slate had higher fixed ammonium content than the soils developed from granite. The percentage of fixed ammonium to total N in the upland soils is always higher than that in the paddy soils. It ranges from 6.1 ±3.6% to 16.6±4.6%, with 14.0% ±5.1% in average for the paddy soils and it amounted to 5.8±2.0% to 40.1 ± 17.8%, with 23.5 ± 14.2% in average for upland soils. （2） The maximum capacity of ammonium fixation has the same trend with the fixed ammonium content in the tested soils. For all the tested soils, the percentage of recently fixed ammonium to maximum capacity of ammonium fixation is always bellow 20% and it may be due to the fact that the soils have high fertility and high saturation of ammonium-fixing site. （3） The clay content and clay composition in the tested soils are the two important factors influencing their fixed ammonium content and maximum capacity of ammonium fixation. The results showed that hydrous mica is the main 2：1 type clay mineral in 〈 0.02 mm clay of the paddy soils, and its content in 0.02-0.002 mm clay is much higher than that in 〈 0.002 mm clay of the soils. The statistical analysis showed that both the fixed ammonium content and the maximum capacity of ammonium fixation of the paddy soils were positively correlated with the total 2：1 type clay mineral content and hydrous mica content in 〈 0.02 mm clay and 0,02-0.002 mm clay at the significant level of P0.01 or P0.05, respectively, but not correlated with the total 2：1 type clay mineral content and hydrous mica content in 〈0.002 mm clay significantly, It demonstrated that the ammonium-fixing matrix of the tested soils mainly exists in the 0.02-0.002 mm clay. The above-mentioned results showed that fixed ammonium is a major form of N in the tillage soils in Hunan Province, China. It would play an important role in N nutrition of crops, especially for upland crops, and deserve to be further researched.展开更多
Using the 1970-2005 annual precipitation and evaporation data at 80 gauge stations across Hunan province,this work analyzes the spatial distribution and variation tendency of the local droughts and floods using linear...Using the 1970-2005 annual precipitation and evaporation data at 80 gauge stations across Hunan province,this work analyzes the spatial distribution and variation tendency of the local droughts and floods using linear regression,wavelet analysis,abrupt change,clusters,Empirical Orthogonal Function (EOF) and rotated EOF (REOF).Results show that there are four dry areas and three wet areas in Hunan.The whole province exhibits a moistening trend except some small areas in western,eastern and southern Hunan.The most prominent feature of annual precipitation is that the whole province basically displays a consistent variation tendency,as far as the dominant EOF mode is concerned.In addition,the spatial features of the other EOF modes include dry-wet differences,e.g.wet (or dry) in the north versus dry (or wet) in the south,wet (or dry) in the center and dry (or wet) in the surrounding areas.The distribution of the ratios of evaporation to precipitation exhibits both common features as well as spatial differences,which can be classified into four types:South Hunan,North Hunan,Northeast Hunan,and Central Hunan.There is an abrupt change from dry to wet patterns in the early 1990s.Generally,the drought-flood distribution presents variations of three periods.In the late 2000s,Hunan province will be in a period of drought,followed by a period of flood.展开更多
A new species of gekkonid,Hemiphyllodactylus dupanglingensis sp.nov.,is described based on six specimens from Hunan Province,China.The new species is phylogenetically close to H.zugi,H.hongkongensis,H.dushanensis,and ...A new species of gekkonid,Hemiphyllodactylus dupanglingensis sp.nov.,is described based on six specimens from Hunan Province,China.The new species is phylogenetically close to H.zugi,H.hongkongensis,H.dushanensis,and H.huishuiensis,and can be distinguished from its congeners by the following combination of cha racters:9-11 chin scales;postmental scales enlarged;9-12 infralabials,11-14 supralabials;14-16 dorsal scales and 10-11 ventral scales longitudinally arranged at the midbody contained with one eye diameter;a manual lamellar formula of 4-4-5-4 or 4-5-5-4 and a pedal lamellar formula of 4-5-5-5 or 5-6-6-4;21-25 continuous precloacal and femoral pores in males.展开更多
Previous studies show that actin-binding Rho activating protein （Abra） is expressed in cardiomyocytes and vascular smooth muscle cells. In this study, we investigated the expression profile of Abra in the central ne...Previous studies show that actin-binding Rho activating protein （Abra） is expressed in cardiomyocytes and vascular smooth muscle cells. In this study, we investigated the expression profile of Abra in the central nervous system of normal adult rats by confocal immunofluorescence. Results showed that Abra immunostaining was located in neuronal nuclei, cytoplasm and processes in the central nervous system, with the strongest staining in the nuclei; in the cerebral cortex, Abra positive neuronal bodies and processes were distributed in six cortical layers including molecular layer, external granular layer, external pyramidal layer, internal granular layer, internal pyramidal layer and polymorphic layer; in the hippocampus, the cell bodies of Abra positive neurons were distributed evenly in pyramidal layer and granular layer, with positive processes in molecular layer and orien layer; in the cerebellar cortex, Abra staining showed the positive neuronal cell bodies in Purkinje cell layer and granular layer and positive processes in molecular layer; in the spinal cord, Abra-immunopositive products covered the whole gray matter and white matter; co-localization studies showed that Abra was co-stained with F-actin in neuronal cytoplasm and processes, but weakly in the nuclei. In addition, in the hippocampus, Abra was co-stained with F-actin only in neuronal processes, but not in the cell body. This study for the first time presents a comprehensive overview of Abra expression in the central nervous system, providing insights for further investigating the role of Abra in the mature central nervous system.展开更多
By using the third-order Wentzel-Kramers-Brillouin approximation and the monodromy methods, the quasnormal modes of a coupled scalar field in the canonical non-rotating acoustic black hole spacetime are investigated. ...By using the third-order Wentzel-Kramers-Brillouin approximation and the monodromy methods, the quasnormal modes of a coupled scalar field in the canonical non-rotating acoustic black hole spacetime are investigated. It is shown that the coupling between the scalar field and background metric affects the quasinormal frequencies. At low overtones, both the real part and the magnitude of imaginary part increase with the couple factor ξ. For the larger ξ, both of them are almost linearly related to the couple factor. At high overtones, it is found that the frequency formula of the quasinormal modes is 2πω/κ = ln （ 1 ＋ 2 cos√9-24ξ/5 π） - i（2n ＋ 1）π, which means that 5 when ξ is larger, the real part is the linear function of ξ^1/2.展开更多
We study the random motion of a charged test particle with a normal classical constant velocity in a spacetime with a perfectly reflecting plane boundary and calculate both the velocity and position dispersions of the...We study the random motion of a charged test particle with a normal classical constant velocity in a spacetime with a perfectly reflecting plane boundary and calculate both the velocity and position dispersions of the test particle. Our results show that the dispersions in the normal direction are weakened while those in the parallel directions are strengthened as compared to the classical static case when the test particle classically moves away from the boundary. However, if the classical motion reverses its direction, then the dispersions in the normal direction are reinforced while those in the parallel directions get weakened.展开更多
We describe a new species from the family Salamandridae from northeastern Hunan Province of China based on morphological and molecular genetic evidences.The new species,Tylototriton liuyangensis,is a member of the T.a...We describe a new species from the family Salamandridae from northeastern Hunan Province of China based on morphological and molecular genetic evidences.The new species,Tylototriton liuyangensis,is a member of the T.asperrimus group,and shares a number of similarities with T.wenxianensis and T.broadoridgus.The dorsal surface of the new Tylototriton species is completely black,with nodule-like warts distributed evenly along the lateral margin of dorsal body,and there is no transverse striae between the warts.There are several diagnostic characters of the new species that differ from those of T.wenxianensis and T.broadoridgus as follows：（1）the interorbital space（IOS）is comparatively wide;（2）there is a bony ridge present on the dorsal head surface,running along the upper eyelids;（3）the space between axilla and groin（AGS）is comparatively large,with the mean male AGS approximately equal to 50%of the snout-vent length（SVL）and the mean female AGS being 53%of SVL;and（4）there is a small genital armature on the anterior angle of labial folds present inside the anal fissure of adult males during the breeding season.The result from the molecular phylogenetic analysis of the genus Tylototriton（including the type specimen of the new species）based on the complete DNA sequence of the mitochondrial ND2 gene（1035 bp）indicated that the new species was similar to T.wenxianensis,T.dabienicus,and T.broadoridgus,but formed an independent clade.This result was consistent with the morphological analysis above,supporting that the Liuyang Population represented a distinct species.展开更多
Background With an aggravated social ageing level, the number of patients with Alzheimer's disease (AD) is gradually increasing, and mild cognitive impairment (MCI) is considered to be an early form of Alzheimer&#...Background With an aggravated social ageing level, the number of patients with Alzheimer's disease (AD) is gradually increasing, and mild cognitive impairment (MCI) is considered to be an early form of Alzheimer's disease. How to distinguish diseases in the early stage for the purposes of early diagnosis and treatment is an important topic. Aims The purpose of our study was to investigate the differences in brain cortical thickness and surface area among elderly patients with AD, elderly patients with amnestic MCI (aMCI) and normal controls (NC). Methods 20 AD patients, 21 aMCIs and 25 NC were recruited in the study. FreeSurfer software was used to calculate cortical thickness and surface area among groups. Results The patients with AD had less cortical thickness both in the left and right hemisphere in 17 of the 36 brain regions examined than the patients with aMCI or NC. The patients with AD also had smaller cerebral surface area both in the left and right hemisphere in 3 of the 36 brain regions examined than the patients with aMCI or NC. Compared with the NC, the patients with aMCI only had slight atrophy in the inferior parietal lobe of the left hemisphere, and no significant difference was found. Conclusion AD, as well as aMCI (to a lesser extent), is associated with reduced cortical thickness and surface area in a few brain regions associated with cognitive impairment. These results suggest that cortical thickness and surface area could be used for early detection of AD.展开更多
In this paper,we first discuss the boundedness of certain integral operator T_(t) on the normal weight general function space F(p,μ,s)in the unit ball Bnof C^(n).As an application of this operator,we prove that the G...In this paper,we first discuss the boundedness of certain integral operator T_(t) on the normal weight general function space F(p,μ,s)in the unit ball Bnof C^(n).As an application of this operator,we prove that the Gleason’s problem is solvable on F(p,μ,s).展开更多
The massless scalar quasiaormal modes （QNMs） of a stationary axisymmetric Einstein-Maxwell dilato-axioa （EMDA） black hole are calculated numerically using the continued fraction method first proposed by Leaver. Th...The massless scalar quasiaormal modes （QNMs） of a stationary axisymmetric Einstein-Maxwell dilato-axioa （EMDA） black hole are calculated numerically using the continued fraction method first proposed by Leaver. The fundamental quasinormal frequencies （slowly damped QNMs） are obtained and the peculiar behaviours of them are studied. It is shown that these frequencies depend on the dilaton parameter D, the rotational parameter a, the multiple moment l and the azimuthal number m, and have the same values with other authors at the Schwarzschild and Kerr limit.展开更多
基金Under the auspices of the National Natural Science Foundation of China(No.42471241,41971219,41571168)Hunan Provincial Natural Science Foundation(No.2020JJ4372)。
文摘In the context of the era of carbon peaking and carbon neutrality,clarifying the emission patterns of non-CO_(2)Greenhouse Gas(GHG)from agricultural sources is of practical significance to China’s implementation of greenhouse gas emission reduction policies.The Intergovernmental Panel on Climate Change(IPCC)coefficient method was used to calculate non-CO_(2)GHG emissions from agricultural sources in 122 counties in Hunan Province,China,from 2010 to 2020,and the spatiotemporal evolution characteristics of emission intensity were analyzed.The Stochastic Impacts by Regression on Population,Affluence,and Technology(STRIPAT)model forecasted the prospective evolution of non-CO_(2)GHG emissions from agricultural sources at the county level under various scenarios from 2030 to 2050.The results demonstrated a general decline in non-CO_(2)GHG emissions from agricultural sources within the study area,with 75.41%of counties exhibiting a reduction in emissions.Geographically,emissions were higher in the Dongting Lake area and central Hengyang.The emission intensity per unit of agricultural added value and the intensity per unit of agricultural land area showed an overall downward trend.Spatially,the emission intensity per unit of farmland area in a few counties(cities,districts)in southern Hunan was still relatively high.By forecasting the non-CO_(2)GHG emissions from agricultural sources,the majority of counties(cities and districts)demonstrated a gradual decline in emissions,suggesting that agricultural production had the potential to reduce emissions in the future,while also facing certain pressure to reduce emissions.It is recommended that Hunan Province formulate agricultural carbon emission reduction policies that take regional development differences into account.This would provide a reference for future agricultural carbon emission reduction research in the whole country.
文摘This longitudinal study investigated how self-management and learning burnout influences the relationship between habitual mobile phone use and subjective well-being amongfirst-year university students.A sample of 1172 Chinese university students participated in a two-wave survey,with data collected six months apart at two time points(T1,T2).The results of Pearson correlation revealed that higher habitual mobile phone use at T1 was associated with lower subjective well-being at T2.Self-management was associated with healthy phone use habits and higher subjective wellbeing.Learning burnout risk was higher with habitual phone usage.Lower self-management and learning burnout at T2 played a chain mediating role between habitual mobile phone use at T1 and subjective well-being at T2 so that subjective well-being was much lower that with either of the variables alone.Overall,thesefindings suggest that habitual mobile phone use is a reliable predictor of college student’s subjective well-being,by their self-management and level of learning burnout over time.This research highlights the long-term impact of habitual mobile phone use on students’subjective well-being and provides valuable insights for developing effective interventions to support students well-being.
基金supported by the National Natural Science Foundation of China(NSFC)under grant No.62371187the Hunan Provincial Natural Science Foundation of China under Grant Nos.2024JJ8309 and 2023JJ50495.
文摘The integration of cloud computing into traditional industrial control systems is accelerating the evolution of Industrial Cyber-Physical System(ICPS),enhancing intelligence and autonomy.However,this transition also expands the attack surface,introducing critical security vulnerabilities.To address these challenges,this article proposes a hybrid intrusion detection scheme for securing ICPSs that combines system state anomaly and network traffic anomaly detection.Specifically,an improved variation-Bayesian-based noise covariance-adaptive nonlinear Kalman filtering(IVB-NCA-NLKF)method is developed to model nonlinear system dynamics,enabling optimal state estimation in multi-sensor ICPS environments.Intrusions within the physical sensing system are identified by analyzing residual discrepancies between predicted and observed system states.Simultaneously,an adaptive network traffic anomaly detection mechanism is introduced,leveraging learned traffic patterns to detect node-and network-level anomalies through pattern matching.Extensive experiments on a simulated network control system demonstrate that the proposed framework achieves higher detection accuracy(92.14%)with a reduced false alarm rate(0.81%).Moreover,it not only detects known attacks and vulnerabilities but also uncovers stealthy attacks that induce system state deviations,providing a robust and comprehensive security solution for the safety protection of ICPS.
基金funded by the National Natural Science Foundation of China under Grant No.62371187the Open Program of Hunan Intelligent Rehabilitation Robot and Auxiliary Equipment Engineering Technology Research Center under Grant No.2024JS101.
文摘The ubiquity of mobile devices has driven advancements in mobile object detection.However,challenges in multi-scale object detection in open,complex environments persist due to limited computational resources.Traditional approaches like network compression,quantization,and lightweight design often sacrifice accuracy or feature representation robustness.This article introduces the Fast Multi-scale Channel Shuffling Network(FMCSNet),a novel lightweight detection model optimized for mobile devices.FMCSNet integrates a fully convolutional Multilayer Perceptron(MLP)module,offering global perception without significantly increasing parameters,effectively bridging the gap between CNNs and Vision Transformers.FMCSNet achieves a delicate balance between computation and accuracy mainly by two key modules:the ShiftMLP module,including a shift operation and an MLP module,and a Partial group Convolutional(PGConv)module,reducing computation while enhancing information exchange between channels.With a computational complexity of 1.4G FLOPs and 1.3M parameters,FMCSNet outperforms CNN-based and DWConv-based ShuffleNetv2 by 1%and 4.5%mAP on the Pascal VOC 2007 dataset,respectively.Additionally,FMCSNet achieves a mAP of 30.0(0.5:0.95 IoU threshold)with only 2.5G FLOPs and 2.0M parameters.It achieves 32 FPS on low-performance i5-series CPUs,meeting real-time detection requirements.The versatility of the PGConv module’s adaptability across scenarios further highlights FMCSNet as a promising solution for real-time mobile object detection.
基金supported by Key Research and Development Plan of Hunan Province(2024DK2006)the Fundamental Research Funds for the Central Universities of Central South University(1053320221769)+2 种基金Hunan Provincial Respiratory Disease Rehabilitation and Nursing Engineering Research Center Innovation Capacity Building Project(No.202012)the Zhangjiajie Science and Technology Development Key Special Project(No.202304)the National Key Clinical Specialty Major Scientific Research Project(No.20230382).
文摘Background:Glioblastoma(GBM)prognosis has seen little improvement over the past two decades.While immunotherapy has revolutionized cancer treatment,its impact on GBM remains limited.To characterize the evolving research landscape and identify future directions in GBM immunotherapy,we conducted a comprehensive bibliometric review.Methods:All literature related to immunotherapy in GBM from 1999 to 2024 was collected from the Web of Science Core Collection.CtieSpace and VOSviewer were used to conduct bibliometric analysis and visualize the data.Results:Bibliometric analysis identified 5038 publications authored by 23,335 researchers from 4699 institutions across 96 countries/regions,published in 945 journals.The United States produced the highest number of publications,while Switzerland achieved the highest average citation rate.Duke University led in institutional output and citations.John H Sampson was the most productive author,and Roger Stupp was the most cited.Frontiers in Immunology published the most papers,while Clinical Cancer Research was the most cited journal.Research focus centered on adoptive T cell therapy,particularly chimeric antigen receptor(CAR)-T cells with 572 dedicated publications.Within CAR-T research for GBM,the University of Pennsylvania was the leading institution,Frontiers in Immunology the predominant journal,and Christine E Brown(City of Hope National Medical Center)was the most prolific and cited author.Conclusions:There has been a growing interest in GBM immunotherapy over past decades.The United States is the dominant contributor.CAR-T therapy represents the primary research focus.Emerging strategies like chimeric antigen receptor-modified natural killer(CAR-NK)cells,chimeric antigen receptor-engineered macrophages(CAR-M),and cytomegalovirus-specific T cell receptor(CMV-TCR)T cells are gaining prominence,aiming to address limitations in antigen recognition inherent to CAR-T therapy for GBM.
基金supported by Grants from the National Science Foundation of China (30771170, 30971105)a General Grant from China Postdoctoral Foundation (20060400260)+1 种基金a Special Grant from China Postdoctoral FoundationScience and Technology Grants from Hunan Province (2008RS4011, 2008NK3108, 2009NK4036)
文摘A new species of Megophrys (Amphibia: Anura: Megophryidae), Megophrys tuberogranulatus Shen, Mo et Li, sp.nov. (Holotype HNUL 03080902, adult male, SVL: 38.2 mm), from Sangzhi County, Hunan Province, is described. Megophrystuberogranulatus is closely related to both Megophrys kuatunensis and Megophrys minor. Characters of the new species that differentiatethis species from close relatives are skin granulated with big tubercles on the dorsal sides of both thigh and tibia, thebigger inner metacarpal tubercle, upper eyelid wider than the interorbital space, hind limbs longer, overlapping of the left andright calcaneal parts. The type specimens are deposited in the Animal Museum of Life Sciences College of Hunan Normal University.
基金supported by the National Natural Science Foundation of China(NSFC-30770316,31071906)the Knowledge Innovation Program of the Chinese Academy of Sciences(KSCX2-EW-J-22)to Jianping JIANG
文摘A new species of the genus Tylototriton is described in this article based on morphological and genetic evidence. The new species is identified belonging to the T. asperrimus group and is similar to T. wenxianensis. The diagnostic characters of the new species are as follows: dorsal ridge broad and thick,its width approximately equal to eye diameter(P < 0.001); tail height greater than width at base of tail(P < 0.001); no villous genital papilla found inside the male anal fissure; nodule-like warts,along lateral margin of the trunk,bulge and forming tubercles,and thin and transverse striae present between the tubercles.
基金Project supported by the National Natural Science Foundation of China(Grant Nos.11774088 and 11474090)。
文摘In high intensity focused ultrasound(HIFU)treatment,it is crucial to accurately identify denatured and normal biological tissues.In this paper,a novel method based on compressed sensing(CS)and refined composite multi-scale fuzzy entropy(RCMFE)is proposed.First,CS is used to denoise the HIFU echo signals.Then the multi-scale fuzzy entropy(MFE)and RCMFE of the denoised HIFU echo signals are calculated.This study analyzed 90 cases of HIFU echo signals,including 45 cases in normal status and 45 cases in denatured status,and the results show that although both MFE and RCMFE can be used to identify denatured tissues,the intra-class distance of RCMFE on each scale factor is smaller than MFE,and the inter-class distance is larger than MFE.Compared with MFE,RCMFE can calculate the complexity of the signal more accurately and improve the stability,compactness,and separability.When RCMFE is selected as the characteristic parameter,the RCMFE difference between denatured and normal biological tissues is more evident than that of MFE,which helps doctors evaluate the treatment effect more accurately.When the scale factor is selected as 16,the best distinguishing effect can be obtained.
文摘In order to understand the status of fixed ammonium, fixed ammonium content, maximum capacity of ammonium fixation, and their influencing factors in major types of tillage soils of Hunan Province, China, were studied with sampling on fields, and laboratory incubation and determination. The main results are summarized as follows： （1） Content of fixed ammonium in the tested soils varies greatly with soil use pattern and the nature of parent material. For the paddy soils, it ranges from 135.4 ± 57.4 to 412.8±32,4 mg kg^-1, with 304.7±96.7 mg kg^-1 in average; while it ranges from 59.4 to 435.7 mg kg^-1, with 230.1 ± 89.2 mg kg^-1 in average for the upland soils. The soils developed from limnic material and slate had higher fixed ammonium content than the soils developed from granite. The percentage of fixed ammonium to total N in the upland soils is always higher than that in the paddy soils. It ranges from 6.1 ±3.6% to 16.6±4.6%, with 14.0% ±5.1% in average for the paddy soils and it amounted to 5.8±2.0% to 40.1 ± 17.8%, with 23.5 ± 14.2% in average for upland soils. （2） The maximum capacity of ammonium fixation has the same trend with the fixed ammonium content in the tested soils. For all the tested soils, the percentage of recently fixed ammonium to maximum capacity of ammonium fixation is always bellow 20% and it may be due to the fact that the soils have high fertility and high saturation of ammonium-fixing site. （3） The clay content and clay composition in the tested soils are the two important factors influencing their fixed ammonium content and maximum capacity of ammonium fixation. The results showed that hydrous mica is the main 2：1 type clay mineral in 〈 0.02 mm clay of the paddy soils, and its content in 0.02-0.002 mm clay is much higher than that in 〈 0.002 mm clay of the soils. The statistical analysis showed that both the fixed ammonium content and the maximum capacity of ammonium fixation of the paddy soils were positively correlated with the total 2：1 type clay mineral content and hydrous mica content in 〈 0.02 mm clay and 0,02-0.002 mm clay at the significant level of P0.01 or P0.05, respectively, but not correlated with the total 2：1 type clay mineral content and hydrous mica content in 〈0.002 mm clay significantly, It demonstrated that the ammonium-fixing matrix of the tested soils mainly exists in the 0.02-0.002 mm clay. The above-mentioned results showed that fixed ammonium is a major form of N in the tillage soils in Hunan Province, China. It would play an important role in N nutrition of crops, especially for upland crops, and deserve to be further researched.
基金Project of Key Disciplines of Research of Hunan ProvinceNatural Science Foundation of China (40741002)
文摘Using the 1970-2005 annual precipitation and evaporation data at 80 gauge stations across Hunan province,this work analyzes the spatial distribution and variation tendency of the local droughts and floods using linear regression,wavelet analysis,abrupt change,clusters,Empirical Orthogonal Function (EOF) and rotated EOF (REOF).Results show that there are four dry areas and three wet areas in Hunan.The whole province exhibits a moistening trend except some small areas in western,eastern and southern Hunan.The most prominent feature of annual precipitation is that the whole province basically displays a consistent variation tendency,as far as the dominant EOF mode is concerned.In addition,the spatial features of the other EOF modes include dry-wet differences,e.g.wet (or dry) in the north versus dry (or wet) in the south,wet (or dry) in the center and dry (or wet) in the surrounding areas.The distribution of the ratios of evaporation to precipitation exhibits both common features as well as spatial differences,which can be classified into four types:South Hunan,North Hunan,Northeast Hunan,and Central Hunan.There is an abrupt change from dry to wet patterns in the early 1990s.Generally,the drought-flood distribution presents variations of three periods.In the late 2000s,Hunan province will be in a period of drought,followed by a period of flood.
基金supported by the National Natural Science Foundation of China(Grant No.31472021)the Project for Endangered Wildlife Investigation,Supervision and Industry Regulation of the National Forestry and Grassland Bureau of China(No.2019072-HN-001)。
文摘A new species of gekkonid,Hemiphyllodactylus dupanglingensis sp.nov.,is described based on six specimens from Hunan Province,China.The new species is phylogenetically close to H.zugi,H.hongkongensis,H.dushanensis,and H.huishuiensis,and can be distinguished from its congeners by the following combination of cha racters:9-11 chin scales;postmental scales enlarged;9-12 infralabials,11-14 supralabials;14-16 dorsal scales and 10-11 ventral scales longitudinally arranged at the midbody contained with one eye diameter;a manual lamellar formula of 4-4-5-4 or 4-5-5-4 and a pedal lamellar formula of 4-5-5-5 or 5-6-6-4;21-25 continuous precloacal and femoral pores in males.
基金supported by the National Natural Science Foundation of China,No.30971532Ph.D.Programs Foundation of Ministry of Education of China,No.20090162110063+1 种基金the Natural Science Foundation of Hunan Province,No.09JJ5015the Scientific Research Program of Hunan Provincial Higher Education Institutes,No.110541
文摘Previous studies show that actin-binding Rho activating protein （Abra） is expressed in cardiomyocytes and vascular smooth muscle cells. In this study, we investigated the expression profile of Abra in the central nervous system of normal adult rats by confocal immunofluorescence. Results showed that Abra immunostaining was located in neuronal nuclei, cytoplasm and processes in the central nervous system, with the strongest staining in the nuclei; in the cerebral cortex, Abra positive neuronal bodies and processes were distributed in six cortical layers including molecular layer, external granular layer, external pyramidal layer, internal granular layer, internal pyramidal layer and polymorphic layer; in the hippocampus, the cell bodies of Abra positive neurons were distributed evenly in pyramidal layer and granular layer, with positive processes in molecular layer and orien layer; in the cerebellar cortex, Abra staining showed the positive neuronal cell bodies in Purkinje cell layer and granular layer and positive processes in molecular layer; in the spinal cord, Abra-immunopositive products covered the whole gray matter and white matter; co-localization studies showed that Abra was co-stained with F-actin in neuronal cytoplasm and processes, but weakly in the nuclei. In addition, in the hippocampus, Abra was co-stained with F-actin only in neuronal processes, but not in the cell body. This study for the first time presents a comprehensive overview of Abra expression in the central nervous system, providing insights for further investigating the role of Abra in the mature central nervous system.
基金Supported by the FANEDD under Grant No 2003052, the Natural Science Foundation of Hunan Province of China under Grant No 05JJ40012 and the Hunan Normal University Natural Science Foundation under Grant No 22040639.
文摘By using the third-order Wentzel-Kramers-Brillouin approximation and the monodromy methods, the quasnormal modes of a coupled scalar field in the canonical non-rotating acoustic black hole spacetime are investigated. It is shown that the coupling between the scalar field and background metric affects the quasinormal frequencies. At low overtones, both the real part and the magnitude of imaginary part increase with the couple factor ξ. For the larger ξ, both of them are almost linearly related to the couple factor. At high overtones, it is found that the frequency formula of the quasinormal modes is 2πω/κ = ln （ 1 ＋ 2 cos√9-24ξ/5 π） - i（2n ＋ 1）π, which means that 5 when ξ is larger, the real part is the linear function of ξ^1/2.
基金The project supported by the National Natural Science Foundation of China under Grant No. 10575035
文摘We study the random motion of a charged test particle with a normal classical constant velocity in a spacetime with a perfectly reflecting plane boundary and calculate both the velocity and position dispersions of the test particle. Our results show that the dispersions in the normal direction are weakened while those in the parallel directions are strengthened as compared to the classical static case when the test particle classically moves away from the boundary. However, if the classical motion reverses its direction, then the dispersions in the normal direction are reinforced while those in the parallel directions get weakened.
基金supported by NSFC (31071906)the Public Welfare Scientific Research Project, Ministry of Environmental Protection of the People’s Republic of China (201209028)the Construct Program of the Key Discipline in Hunan Province (CSUFT-2013001)
文摘We describe a new species from the family Salamandridae from northeastern Hunan Province of China based on morphological and molecular genetic evidences.The new species,Tylototriton liuyangensis,is a member of the T.asperrimus group,and shares a number of similarities with T.wenxianensis and T.broadoridgus.The dorsal surface of the new Tylototriton species is completely black,with nodule-like warts distributed evenly along the lateral margin of dorsal body,and there is no transverse striae between the warts.There are several diagnostic characters of the new species that differ from those of T.wenxianensis and T.broadoridgus as follows：（1）the interorbital space（IOS）is comparatively wide;（2）there is a bony ridge present on the dorsal head surface,running along the upper eyelids;（3）the space between axilla and groin（AGS）is comparatively large,with the mean male AGS approximately equal to 50%of the snout-vent length（SVL）and the mean female AGS being 53%of SVL;and（4）there is a small genital armature on the anterior angle of labial folds present inside the anal fissure of adult males during the breeding season.The result from the molecular phylogenetic analysis of the genus Tylototriton（including the type specimen of the new species）based on the complete DNA sequence of the mitochondrial ND2 gene（1035 bp）indicated that the new species was similar to T.wenxianensis,T.dabienicus,and T.broadoridgus,but formed an independent clade.This result was consistent with the morphological analysis above,supporting that the Liuyang Population represented a distinct species.
基金Collaborative Innovation Center for Translational Medicine at Shanghai Jiao Tong University School of Medicine TM201728National Nature Science Foundation of China 81571298+2 种基金Shanghai health system excellent talent training program (excellent subject leader) project 2017BR054Shanghai Municipal Education Commission-Gaofeng Clinical Medicine Grant Support 20172029Shanghai Pujiang Program 17PJD038.
文摘Background With an aggravated social ageing level, the number of patients with Alzheimer's disease (AD) is gradually increasing, and mild cognitive impairment (MCI) is considered to be an early form of Alzheimer's disease. How to distinguish diseases in the early stage for the purposes of early diagnosis and treatment is an important topic. Aims The purpose of our study was to investigate the differences in brain cortical thickness and surface area among elderly patients with AD, elderly patients with amnestic MCI (aMCI) and normal controls (NC). Methods 20 AD patients, 21 aMCIs and 25 NC were recruited in the study. FreeSurfer software was used to calculate cortical thickness and surface area among groups. Results The patients with AD had less cortical thickness both in the left and right hemisphere in 17 of the 36 brain regions examined than the patients with aMCI or NC. The patients with AD also had smaller cerebral surface area both in the left and right hemisphere in 3 of the 36 brain regions examined than the patients with aMCI or NC. Compared with the NC, the patients with aMCI only had slight atrophy in the inferior parietal lobe of the left hemisphere, and no significant difference was found. Conclusion AD, as well as aMCI (to a lesser extent), is associated with reduced cortical thickness and surface area in a few brain regions associated with cognitive impairment. These results suggest that cortical thickness and surface area could be used for early detection of AD.
基金Supported by the National Natural Science Foundation of China(11942109)the Natural Science Foundation of Hunan Province in China(2022JJ30369)。
文摘In this paper,we first discuss the boundedness of certain integral operator T_(t) on the normal weight general function space F(p,μ,s)in the unit ball Bnof C^(n).As an application of this operator,we prove that the Gleason’s problem is solvable on F(p,μ,s).
基金Project supported by the National Natural Science Foundation of China （Grant No 10473004）, the FADEDD （Grant No 200317）, and the SRFDP （Grant No 20040542003）.
文摘The massless scalar quasiaormal modes （QNMs） of a stationary axisymmetric Einstein-Maxwell dilato-axioa （EMDA） black hole are calculated numerically using the continued fraction method first proposed by Leaver. The fundamental quasinormal frequencies （slowly damped QNMs） are obtained and the peculiar behaviours of them are studied. It is shown that these frequencies depend on the dilaton parameter D, the rotational parameter a, the multiple moment l and the azimuthal number m, and have the same values with other authors at the Schwarzschild and Kerr limit.
