Background Ongoing debates question the harm of internet use with the evolving technology,as many individuals transition from regular to problematic internet use(PIU).The habenula(Hb),located between the thalamus and ...Background Ongoing debates question the harm of internet use with the evolving technology,as many individuals transition from regular to problematic internet use(PIU).The habenula(Hb),located between the thalamus and the third ventricle,is implicated in various psychiatric disorders.In addition,personality features have been suggested to play a role in the pathophysiology of PIU.Aims This study aimed to investigate Hb volumetry in individuals with subclinical PIU and the mediating effect of personality traits on this relationship.Methods 110 healthy adults in this cross-sectional study underwent structural magnetic resonance imaging.Hb segmentation was performed using a deep learning technique.The Internet Addiction Test(IAT)and the NEO Five-Factor Inventory were used to assess the PIU level and personality,respectively.Partial Spearman's correlation analyses were performed to explore the reiationships between Hb volumetry,IAT and NEO.Multiple regression analysis was applied to identify personality traits that predict IAT scores.The significant trait was then treated as a mediator between Hb volume and IAT correlation in mediation analysis with a bootstrap value of 5000.Results Relative Hb volume was negatively correlated with IAT scores(partial rho=-0.142,p=0.009).The IAT score was positively correlated with neuroticism(partial rho=0.430,p<0.001)and negatively correlated with extraversion,agreeableness and conscientiousness(partial rho=-0.213,p<0.001;partial rho=-0.279,p<0.001;and partial rho=-0.327,p<0.001).There was a significant indirect effect of Hb volume on this model(β=-0.061,p=0.048,boot 95%confidence interval:-0.149 to-0.001).Conclusions This study uncovered a crucial link between reduced Hb volume and heightened PIU.Our findings highlight neuroticism as a key risk factor for developing PIU.Moreover,neuroticism was shown to mediate the relationship between Hb volume and PIU tendency,offering valuable insight into the complexities of this interaction.展开更多
BACKGROUND Colorectal cancer is the third most common malignancy and the fourth leading cause of cancer-related deaths worldwide.Several studies have shown an association between gut microbiota and colorectal cancer.G...BACKGROUND Colorectal cancer is the third most common malignancy and the fourth leading cause of cancer-related deaths worldwide.Several studies have shown an association between gut microbiota and colorectal cancer.Gut microbiota is unique and can be influenced by geographic factors and habits.This study aimed to determine the diversity and composition of colonic mucosal microbiota in patients with and without colorectal cancer.AIM To determine the diversity and composition of colonic mucosal microbiota in patients with and without colorectal cancer in Indonesia.METHODS This case-control study included 59 subjects(35 colorectal cancer patients and 24 non-colorectal cancer patients indicated for colonoscopy at Dr.Cipto Mangunkusumo Gastrointestinal Endoscopy Center and Fatmawati Hospital.Microbiota examination was performed using 16S rRNA sequencing.Bioinformatics analysis was performed using the wf-metagenomics pipeline from EPI2Me-Labs(Oxford Nanopore Technologies platform).RESULTS Patients with colorectal cancer had a higher median index value on the Shannon index(3.28 vs 2.82,P>0.05)and a lower value on the Simpson index(0.050 vs 0.060,P>0.05).Significant differences in beta diversity were observed at the genus(P=0.002)and species levels(P=0.001).Firmicutes,Proteobacteria,Bacteroidetes,and Fusobacteria were the dominant phyla.The genera Bacteroides,Campylobacter,Peptostreptococcus,and Parvimonas were found more frequently in colorectal cancer,while Faecalibacterium,Haemophilus,and Phocaeicola were more frequently found in non-colorectal cancer.The relative abundance of Fusobacterium nucleatum,Bacteroides fragilis,Enterococcus faecalis,Campylobacter hominis,and Enterococcus faecalis species was significantly elevated in patients with colorectal cancer.Meanwhile,Faecalibacterium prausnitzii,Faecalibacterium duncaniae,and Prevotella copri were more commonly found in non-colorectal cancer.CONCLUSION Patients with colorectal cancer exhibit distinct differences in the composition and diversity of their colonic mucosal microbiota compared to those with non-colorectal cancer.This study was reviewed and approved by the Ethics Committee of Faculty of Medicine,Universitas Indonesia(No.KET-1517/UN2.F1/ETIK/PPM.00.02/2023).展开更多
To adapt to national climate change strategies,understanding the thermal vulnerability of urban functional zones(UFZs)is critical for enhancing the livability and sustainable development of cities.We address the limit...To adapt to national climate change strategies,understanding the thermal vulnerability of urban functional zones(UFZs)is critical for enhancing the livability and sustainable development of cities.We address the limitations of existing thermal vulnerability assessments by incorporating human perception into the analysis.Specifically,we introduce the sky openness index to reflect human perception of the thermal environment and examine variations in thermal vulnerability across different UFZs.Using the Extreme Gradient Boosting(XGBoost)-SHapley Additive exPlanations(SHAP)model,we analyze the contributions of 2D and 3D urban form indicators to thermal vulnerability and link these contributions to the unique needs and vulnerability characteristics of UFZs of Foshan City,China in 2023.The results reveal that:1)high-value heat-fragile areas(1.74–2.00]constitute 10.42%of Foshan City;2)traffic zone and publiccommercial zone exhibit the highest levels of thermal vulnerability;and 3)building height and the normalized building index are the most influential factors,with contributions of|0.06|and|0.03|,respectively.We provide a scientific foundation for developing governance strategies to promote urban resilience.展开更多
Objectives:Emotional stress is a significant public health challenge.Virtual reality(VR)offers the potential for aiding emotional recovery.This study explores the impact of VR environment design factors on emotional r...Objectives:Emotional stress is a significant public health challenge.Virtual reality(VR)offers the potential for aiding emotional recovery.This study explores the impact of VR environment design factors on emotional recovery,examining underlying mechanisms through physiological indicators and behavioral responses.Methods:Two experimentswere conducted.Experiment 1 employed a 4[Scene Type:real environment(RE),virtual scenes that restore the RE(VR),virtual scenes that incorporate natural window view design(VR-W),and a no-scene control condition(CTL)]×3(Experimental Phase:baseline,emotion arousal,recovery)mixed design(N=33).Participants viewed a 4-min anxiety-inducing video followed by a 3-min scene exposure.State-Trait Anxiety Inventory-State Form(STAIS),galvanic skin response(GSR),and blood-volume pulse(BVP)frequency were analyzed with linear mixed-effects models.Experiment 2 used a 3(Motion-control mode:Unnatural,Semi-natural,Natural)×2(Sound form:Spatial positioning,Surround)×3(Experimental Phase:baseline,emotion arousal,recovery)mixed design(N=42).Presence was analyzed with the Scheirer–Ray–Hare test;phase efficacy was verified with Friedman tests.Results:Experiment 1 showed significant Scene Type×Experimental Phase interactions for GSR(F=8.006,p<0.001,η^(2)_(p)=0.624)and BVP frequency(F=11.491,p<0.001,η^(2)_(p)=0.704).VR-Wproduced the largest recovery(ΔGSR=–1.26;ΔBVP=–5.80;Hedges g≥0.83)vs.RE and VR.STAI-S returned to baseline across all Scene Types.Experiment 2 revealedmain effects of Motion-control mode(F=8.55,p=0.001,η^(2)_(p)=0.32)and Sound form(F=4.35,p=0.044,η^(2)_(p)=0.11)on Presence(Semi-natural+Spatial positioning highest).The greatest physiological recovery occurred with the UnnaturalMotioncontrolmode(GSRH=20.17,p<0.001,ε^(2)=0.49;BVPH=7.92,p=0.019),amplified by Spatial positioning Sound form only in this mode.Design factors did not influence STAI-S change.Conclusions:VR scenes are as restorative as RE;embedding VR-W accelerates recovery.Maximal Presence is not essential:Unnatural Motion-control mode induced the largest physiological recovery,especially combined with Spatial positioning Sound form.展开更多
The contemporary Chinese human rights theory can be deciphered based on the "people-centered" concept. "Putting people in the center " is an approach to deve lopment,a concept of governance and a r...The contemporary Chinese human rights theory can be deciphered based on the "people-centered" concept. "Putting people in the center " is an approach to deve lopment,a concept of governance and a ruling orientation,and it is the idea shaping of the governing party,the ideological guideline for administrative organs and the principle of action for relevant personnel.The human rights system is thoughts,theories,systems and practice proposed by social groups and individuals to the social authority,especially the resource provider,around the basic demands for subsistence and development.Fundamentally speaking,the "people-centered" approach and the human rights system,though belonging to different political ethics and political philosophy fields,share many common points or similarities in their specific way of existence and operation process.Therefore,there is coherence between the "people-centered" approach and human rights,and there is systematic compatibility between the human rightsbased way of thinking and the people-centered governing concept.The two approaches share many commonalities in the implementation measures and actions,both requiring the integration of concepts,norms,systems and actions.The deciphering helps China to provide wisdom and marke contributions in enriching world human rights theories.展开更多
The right to subsistence and the right to development are the primary basic human rights,and there is a certain connection between the two.Although they refer to different things,they are mutually dependent and restri...The right to subsistence and the right to development are the primary basic human rights,and there is a certain connection between the two.Although they refer to different things,they are mutually dependent and restricted.It is necessary to distinguish the right to development as a means and the right to development as an end.The former is the right to participate in,promote,and enjoy development,while the latter is the right of all people to enjoy free,comprehensive,and harmonious development.The protection of the right to subsistence and the right to development form an interacting virtuous cycle under certain conditions.The process of building a moderately prosperous society embodies this virtuous cycle.To build a modern socialist country in an all-round way,it is still necessary to keep on promoting the virtuous cycle between the right to subsistence and the right to development.展开更多
In the context of building a country with a strong transportation network,railway container transportation(RCT)is an important means of reducing costs,increasing efficiency,and adjusting transportation structures.Thus...In the context of building a country with a strong transportation network,railway container transportation(RCT)is an important means of reducing costs,increasing efficiency,and adjusting transportation structures.Thus,its impact on regional economic development is important.Based on data from railway container-handling stations and spatial econometric models,this study discusses the differences in the development of RCT and their impact on regional economic development at different leves.This study has three main findings:first,there are significant regional differences in the development of the RCT.The intra-regional differences between the eastern and central regions of China(which do not include Hong Kong,Macao and Taiwan)are gradually narrowing,while the regional differences in the western region are widening.Meanwhile,the intra-regional differences in important economic zones such as Pearl River Delta Economic Zone(PRDEZ),Chengdu-Chongqing Economic Zone(CYEZ),Bohai Rim Economic Zone(BHEZ),and Yangtze River Delta Economic Zone(YRDEZ)are narrowing daily.Second,the development differences of RCT in regional level and important economic regions level show different trends.The unbalanced features of large regions are increasingly evident,whereas the differences in economic regions are decreasing.However,the problem of overlapping RCT remains prominent.Third,the transformation of RCT development mode and fierce competition among transportation modes cause RCT to have a restraining effect on the regional economy at three levels.Rational allocation of resources and other means must be used to guide the transformation from inhibition to promotion,and by formulating targeted policies that will promote the development of RCT,which will improve the transportation structure and help construct a country with a strong transportation system.展开更多
The development of China’s human rights path is driven by both external and internal factors,influenced by general principles of human rights worldwide while also following China’s own endogenous logic.The concept o...The development of China’s human rights path is driven by both external and internal factors,influenced by general principles of human rights worldwide while also following China’s own endogenous logic.The concept of the“Two Integrations”reflects the continuous theoretical innovation of the Chinese Communist Party based on China’s national conditions,significantly illustrating the endogenous logic of China’s human rights path.Among these,the“basic principles of Marxism”occupy a“core”position within the endogenous logic of China’s human rights path,and to some extent,embody an understanding of the inherent laws of human rights.Meanwhile,“China’s specific realities”and“fine traditional Chinese culture”serve as the“living water sources”for the ongoing advancement of China’s human rights.The“Two Integrations”represent an intrinsic requirement of historical materialism and practical materialism.The logical structure of“One Core,Two Sources”explains the endogenous nature of China’s human rights path,offering both an interpretation of the driving forces behind China’s human rights path and a defense of its rationality.展开更多
Localization is crucial in wireless sensor networks for various applications,such as tracking objects in outdoor environments where GPS(Global Positioning System)or prior installed infrastructure is unavailable.Howeve...Localization is crucial in wireless sensor networks for various applications,such as tracking objects in outdoor environments where GPS(Global Positioning System)or prior installed infrastructure is unavailable.However,traditional techniques involve many anchor nodes,increasing costs and reducing accuracy.Existing solutions do not address the selection of appropriate anchor nodes and selecting localized nodes as assistant anchor nodes for the localization process,which is a critical element in the localization process.Furthermore,an inaccurate average hop distance significantly affects localization accuracy.We propose an improved DV-Hop algorithm based on anchor sets(AS-IDV-Hop)to improve the localization accuracy.Through simulation analysis,we validated that the ASIDV-Hop proposed algorithm is more efficient in minimizing localization errors than existing studies.The ASIDV-Hop algorithm provides an efficient and cost-effective solution for localization in Wireless Sensor Networks.By strategically selecting anchor and assistant anchor nodes and rectifying the average hop distance,AS-IDV-Hop demonstrated superior performance,achieving a mean accuracy of approximately 1.59,which represents about 25.44%,38.28%,and 73.00%improvement over other algorithms,respectively.The estimated localization error is approximately 0.345,highlighting AS-IDV-Hop’s effectiveness.This substantial reduction in localization error underscores the advantages of implementing AS-IDV-Hop,particularly in complex scenarios requiring precise node localization.展开更多
Many cities face heat wave(HW) events, combined with the existent surface urban heat island(SUHI) effects. This places pressure on human settlements and sustainable development. However, few studies have investigated ...Many cities face heat wave(HW) events, combined with the existent surface urban heat island(SUHI) effects. This places pressure on human settlements and sustainable development. However, few studies have investigated the SUHI effects from the perspective of HWs. In this study, the summer HWs in Beijing from 2001 to 2021 were calculated, and the evolution of HWs and SUHIs was quantitatively analyzed based on the dynamic nature of the urban-rural boundary. Beijing experienced 27 HWs in the 21 years, including 10 instances in June, four in July, and 13 in August. The SUHI varied during HWs, between 2–3℃ in most years. The highest SUHI occurred in 2019, reaching 3.99℃ and covering the largest area(10,887 km^(2)). The fluctuation in HWs and SUHIs generally displayed the same spatiotemporal pattern, and HWs amplified the SUHIs to a certain extent, with the highest correlation coefficient being 0.44. Additionally, impervious surfaces and cropland contributed most to SUHIs,and night light enhanced SUHIs. Observing the co-evolution of HWs and SUHIs will be helpful for ecological maintenance and urban infrastructure optimization and provide theoretical support for reducing heat risk and improving the human settlement environment.展开更多
The activity of occipitotemporal regions involved in linguistic reading processes,such as the ventral occipitotemporal cortex(vOT),is believed to exhibit strong interactions during higher-order language processing,spe...The activity of occipitotemporal regions involved in linguistic reading processes,such as the ventral occipitotemporal cortex(vOT),is believed to exhibit strong interactions during higher-order language processing,specifically in the connectivity between the occipital gyrus and the temporal gyrus.In this study,we utilized functional magnetic resonance imaging(fMRI)with psychophysiological interaction(PPI)and dynamic causal modeling(DCM)to investigate the functional and effective connectivity in the occipitotemporal network during speed reading.We conducted the experiment with native Japanese speakers who underwent and without speed-reading training and subsequently performed established reading tasks at different speeds(slow,medium,and fast)while undergoing 3-Tesla Siemens fMRI.Our activation analyses revealed significant changes in occipital and temporal regions as reading speed increased,indicating functional connectivity within the occipitotemporal network.DCM results further demonstrated more intricate effective connections and high involvement within the occipitotemporal pathway:(1)reading signals originated from the inferior occipital gyrus(iO),distributed to the vOT and the posterior superior temporal sulcus(pSTS),and then gathered in the anterior superior temporal sulcus(aSTS);(2)reading speed loads had modulation effects on the pathways from the aSTS to vOT and from the iO to vOT.These findings highlight the complex connectivity and dynamic interactions within the occipitotemporal network during speed-reading processes.展开更多
Carboxyl ester lipase(CEL),a pivotal enzyme involved in lipid metabolism,is recurrently mutated in obese mice.Here,we aimed to elucidate the functional significance,molecular mechanism,and therapeutic potential of CEL...Carboxyl ester lipase(CEL),a pivotal enzyme involved in lipid metabolism,is recurrently mutated in obese mice.Here,we aimed to elucidate the functional significance,molecular mechanism,and therapeutic potential of CEL in metabolic dysfunction-associated steatohepatitis(MASH).Hepatocyte-specific carboxyl ester lipase gene(Cel)knockout(Cel^(DHEP))and wildtype(WT)littermates were fed with cholinedeficient high-fat diet(CD-HFD)for 16 weeks,or methionine-and choline-deficient diet(MCD)for three weeks to induce MASH.Liquid chromatography–mass spectrometry and co-immunoprecipitation were employed to identify the downstream targets of CEL.CD-HFD/MCD-fed WT mice received intravenous injections of CEL-adeno-associated viral,serotype 8(AAV8)to induce specific overexpression of CEL in the liver.We observed a decrease in CEL protein levels in MASH induced by CD-HFD or MCD in mice.Cel^(DHEP) mice fed with CD-HFD or MCD exhibited pronounced hepatic steatosis,inflammation,lipid peroxidation,and liver injury compared to WT littermates,accompanied by increased hepatic nuclear factor kappa-light-chain-enhancer of activated B cell(NF-jB)activation.Consistently,Cel knockdown in mouse primary hepatocytes and AML12 cells aggravated lipid accumulation and inflammation,whereas CEL overexpression exerted the opposite effect.Mechanistically,CEL directly bound to fatty acid synthase(FASN),resulting in reduced FASN SUMOylation,which in turn promoted FASN degradation through the proteasome pathway.Furthermore,inhibition of FASN ameliorated hepatocyte lipid accumulation and inflammation induced by Cel knockdown in vivo and in vitro.Hepatocyte-specific CEL overexpression using AAV8-Cel significantly mitigated steatohepatitis in mice fed with CD-HFD or MCD.CEL protects against steatohepatitis development by directly interacting with FASN and suppressing its expression for de novo lipogenesis.CEL overexpression confers a therapeutic benefit in steatohepatitis.展开更多
Metagenomics has opened new avenues for exploring the genetic potential of uncultured microorganisms,which may serve as promising sources of enzymes and natural products for industrial applications.Identifying enzymes...Metagenomics has opened new avenues for exploring the genetic potential of uncultured microorganisms,which may serve as promising sources of enzymes and natural products for industrial applications.Identifying enzymes with improved catalytic properties from the vast amount of available metagenomic data poses a significant challenge that demands the development of novel computational and functional screening tools.The catalytic properties of all enzymes are primarily dictated by their structures,which are predominantly determined by their amino acid sequences.However,this aspect has not been fully considered in the enzyme bioprospecting processes.With the accumulating number of available enzyme sequences and the increasing demand for discovering novel biocatalysts,structural and functional modeling can be employed to identify potential enzymes with novel catalytic properties.Recent efforts to discover new polysaccharide-degrading enzymes from rumen metagenome data using homology-based searches and machine learning-based models have shown significant promise.Here,we will explore various computational approaches that can be employed to screen and shortlist metagenome-derived enzymes as potential biocatalyst candidates,in conjunction with the wet lab analytical methods traditionally used for enzyme characterization.展开更多
Many epidemiological and experimental studies have suggested that dietary fiber plays an important role in colon cancer prevention. These findings may relate to the ability of fiber to reduce the contact time of carci...Many epidemiological and experimental studies have suggested that dietary fiber plays an important role in colon cancer prevention. These findings may relate to the ability of fiber to reduce the contact time of carcinogens within the intestinal lumen and to promote healthy gut microbiota, which modifies the host's metabolism in various ways. Elucidation of the mechanisms by which dietary fiber-dependent changes in gut microbiota enhance bile acid deconjugation, produce short chain fatty acids, and modulate inflammatory bioactive substances can lead to a better understanding of the beneficial role of dietary fiber. This article reviews the current knowledge concerning the mechanisms via which dietary fiber protects against colon cancer.展开更多
Royal jelly (R J)from honeybee has been widely used as a health promotion supplement.The major royal jelly proteins (MRJPs)have been identified as the functional component of RJ.However,the question of whether MRJPs h...Royal jelly (R J)from honeybee has been widely used as a health promotion supplement.The major royal jelly proteins (MRJPs)have been identified as the functional component of RJ.However,the question of whether MRJPs have anti-senescence activity for human cells remains.Human embryonic lung fibroblast (HFL-I)cells were cultured in media containing no MRJPs (A),MRJPs at 0.1mg/ml (B),0.2mg/ml (C),or 0.3mg/ml (D),or bovine serum albumin (BSA)at 0.2mg/ml (E).The mean population doubling levels of cells in media B,C,D,and E were increased by 12.4%,31.2%,24.0%,and 10.4%,respectively,compared with that in medium A.The cells in medium C also exhibited the highest relative proliferation activity,the lowest senescence,and the longest telomeres.Moreover, MRJPs up-regulated the expression of superoxide dismutase-1(SOD1)and down-regulated the expression of mammalian target of rapamycin (MTOR),catenin beta like-1(CTNNB1),and tumor protein p53(TP53).Raman spectra analysis showed that there were two unique bands related to DNA synthesis materials,amide carbonyl group vibrations and aromatic hydrogens.These results suggest that MRJPs possess anti-senescence activity for the HFL-I cell line,and provide new knowledge illustrating the molecular mechanism of MRJPs as anti-senescence factors.展开更多
Turmeric residue（TR）, containing residual levels of curcumin, is a solid by-product waste generated after the extraction and separation of curcumin from turmeric root. A feeding trial was conducted to evaluate the e...Turmeric residue（TR）, containing residual levels of curcumin, is a solid by-product waste generated after the extraction and separation of curcumin from turmeric root. A feeding trial was conducted to evaluate the effects of TR on the survival of Chinese soft-shelled turtles（SSTs）, Pelodiscus sinensis, under a high ambient temperature. A total of 320 female SSTs were assigned randomly to two diets： basal diet（the control group, n=160） and an interventional diet supplemented with 10% TR（the TR group, n=160）. Our results demonstrated that supplementation of TR increased the SST survival rate by 135.5%, and superoxide dismutase（SOD） activity of SST liver by 112.8%, and decreased the malondialdehyde（MDA） content of SST liver by 36.4%, compared to the control group. The skin of the SST fed TR showed a golden color. High-performance liquid chromatography（HPLC） analysis indicated that the concentrations of curcumin in TR and the skin of the SST fed TR were（1.69±0.30） and（0.14±0.03） μg/g, respectively. Our observation suggests that supplementation of TR increased the survival rate of SST under high ambient temperatures. We speculated that the increased survival rate and tolerance at the high ambient temperature were associated with the anti-oxidation activity of curcumin from TR. Moreover, curcumin in TR could be deposited in SST skin, which made it more favored in the market of China. Our findings provide new knowledge and evidence to effectively reuse TR as a feed additive in animal and aquatic farming.展开更多
This paper describes a multiple camera-based method to reconstruct the 3D shape of a human foot. From a foot database, an initial 3D model of the foot represented by a cloud of points is built. The shape parameters, w...This paper describes a multiple camera-based method to reconstruct the 3D shape of a human foot. From a foot database, an initial 3D model of the foot represented by a cloud of points is built. The shape parameters, which can characterize more than 92% of a foot, are defined by using the principal component analysis method. Then, using ＂active shape models＂, the initial 3D model is adapted to the real foot captured in multiple images by applying some constraints （edge points＇ distance and color variance）. We insist here on the experiment part where we demonstrate the efficiency of the proposed method on a plastic foot model, and also on real human feet with various shapes. We propose and compare different ways of texturing the foot which is needed for reconstruction. We present an experiment performed on the plastic foot model and on human feet and propose two different ways to improve the final 3D shapers accuracy according to the previous experiments＇ results. The first improvement proposed is the densification of the cloud of points used to represent the initial model and the foot database. The second improvement concerns the projected patterns used to texture the foot. We conclude by showing the obtained results for a human foot with the average computed shape error being only 1.06 mm.展开更多
基金funded by a Grant-in-Aid for Scientific Research(B)(Japan Society for The Promotion of Science,21H02849)Grant-in-Aid for Scientific Research(C)(Japan Society for The Promotion of Science,23K07013)+2 种基金Grant-in-Aid for Transformative Research Areas(A)(Japan Society for The Promotion of Science,JP21H05173)Grant-in-Aid by the Smoking Research FoundationGrant-in-Aid by the Telecommunications Advancement Foundation.
文摘Background Ongoing debates question the harm of internet use with the evolving technology,as many individuals transition from regular to problematic internet use(PIU).The habenula(Hb),located between the thalamus and the third ventricle,is implicated in various psychiatric disorders.In addition,personality features have been suggested to play a role in the pathophysiology of PIU.Aims This study aimed to investigate Hb volumetry in individuals with subclinical PIU and the mediating effect of personality traits on this relationship.Methods 110 healthy adults in this cross-sectional study underwent structural magnetic resonance imaging.Hb segmentation was performed using a deep learning technique.The Internet Addiction Test(IAT)and the NEO Five-Factor Inventory were used to assess the PIU level and personality,respectively.Partial Spearman's correlation analyses were performed to explore the reiationships between Hb volumetry,IAT and NEO.Multiple regression analysis was applied to identify personality traits that predict IAT scores.The significant trait was then treated as a mediator between Hb volume and IAT correlation in mediation analysis with a bootstrap value of 5000.Results Relative Hb volume was negatively correlated with IAT scores(partial rho=-0.142,p=0.009).The IAT score was positively correlated with neuroticism(partial rho=0.430,p<0.001)and negatively correlated with extraversion,agreeableness and conscientiousness(partial rho=-0.213,p<0.001;partial rho=-0.279,p<0.001;and partial rho=-0.327,p<0.001).There was a significant indirect effect of Hb volume on this model(β=-0.061,p=0.048,boot 95%confidence interval:-0.149 to-0.001).Conclusions This study uncovered a crucial link between reduced Hb volume and heightened PIU.Our findings highlight neuroticism as a key risk factor for developing PIU.Moreover,neuroticism was shown to mediate the relationship between Hb volume and PIU tendency,offering valuable insight into the complexities of this interaction.
文摘BACKGROUND Colorectal cancer is the third most common malignancy and the fourth leading cause of cancer-related deaths worldwide.Several studies have shown an association between gut microbiota and colorectal cancer.Gut microbiota is unique and can be influenced by geographic factors and habits.This study aimed to determine the diversity and composition of colonic mucosal microbiota in patients with and without colorectal cancer.AIM To determine the diversity and composition of colonic mucosal microbiota in patients with and without colorectal cancer in Indonesia.METHODS This case-control study included 59 subjects(35 colorectal cancer patients and 24 non-colorectal cancer patients indicated for colonoscopy at Dr.Cipto Mangunkusumo Gastrointestinal Endoscopy Center and Fatmawati Hospital.Microbiota examination was performed using 16S rRNA sequencing.Bioinformatics analysis was performed using the wf-metagenomics pipeline from EPI2Me-Labs(Oxford Nanopore Technologies platform).RESULTS Patients with colorectal cancer had a higher median index value on the Shannon index(3.28 vs 2.82,P>0.05)and a lower value on the Simpson index(0.050 vs 0.060,P>0.05).Significant differences in beta diversity were observed at the genus(P=0.002)and species levels(P=0.001).Firmicutes,Proteobacteria,Bacteroidetes,and Fusobacteria were the dominant phyla.The genera Bacteroides,Campylobacter,Peptostreptococcus,and Parvimonas were found more frequently in colorectal cancer,while Faecalibacterium,Haemophilus,and Phocaeicola were more frequently found in non-colorectal cancer.The relative abundance of Fusobacterium nucleatum,Bacteroides fragilis,Enterococcus faecalis,Campylobacter hominis,and Enterococcus faecalis species was significantly elevated in patients with colorectal cancer.Meanwhile,Faecalibacterium prausnitzii,Faecalibacterium duncaniae,and Prevotella copri were more commonly found in non-colorectal cancer.CONCLUSION Patients with colorectal cancer exhibit distinct differences in the composition and diversity of their colonic mucosal microbiota compared to those with non-colorectal cancer.This study was reviewed and approved by the Ethics Committee of Faculty of Medicine,Universitas Indonesia(No.KET-1517/UN2.F1/ETIK/PPM.00.02/2023).
基金Under the auspices of Liaoning Revitalization Talents Program(No.XLYC2202024)Basic Scientific Research Project(Key Project)of the Education Department of Liaoning Province(No.LJ212410165084)the Fundamental Research Funds for the Central Universities(No.N2111003,N2411001)。
文摘To adapt to national climate change strategies,understanding the thermal vulnerability of urban functional zones(UFZs)is critical for enhancing the livability and sustainable development of cities.We address the limitations of existing thermal vulnerability assessments by incorporating human perception into the analysis.Specifically,we introduce the sky openness index to reflect human perception of the thermal environment and examine variations in thermal vulnerability across different UFZs.Using the Extreme Gradient Boosting(XGBoost)-SHapley Additive exPlanations(SHAP)model,we analyze the contributions of 2D and 3D urban form indicators to thermal vulnerability and link these contributions to the unique needs and vulnerability characteristics of UFZs of Foshan City,China in 2023.The results reveal that:1)high-value heat-fragile areas(1.74–2.00]constitute 10.42%of Foshan City;2)traffic zone and publiccommercial zone exhibit the highest levels of thermal vulnerability;and 3)building height and the normalized building index are the most influential factors,with contributions of|0.06|and|0.03|,respectively.We provide a scientific foundation for developing governance strategies to promote urban resilience.
基金funded by the General Project of the National Social Science Fund(NSSF)of China in Art(Project No.23BG133)the Scientific Research Foundation ofWuhan Institute of Technology(Project No.K2023064)+2 种基金the Open Fund of Key Research Base of Humanities and Social Sciences in Hubei Province—Research Center for College Students’Development and Innovation Education:“VR Healing Intervention for College Students’Academic Anxiety—VR Healing Based on Intention Dialogue”(Project No.DXS2023017)the Research Project of China Youth and Children Research Society(Project No.2025B11)the Major Strategic Consulting Projects of the Chinese Academy of Engineering between Academy and Local Regions(Project No.2024-DFZD-41).
文摘Objectives:Emotional stress is a significant public health challenge.Virtual reality(VR)offers the potential for aiding emotional recovery.This study explores the impact of VR environment design factors on emotional recovery,examining underlying mechanisms through physiological indicators and behavioral responses.Methods:Two experimentswere conducted.Experiment 1 employed a 4[Scene Type:real environment(RE),virtual scenes that restore the RE(VR),virtual scenes that incorporate natural window view design(VR-W),and a no-scene control condition(CTL)]×3(Experimental Phase:baseline,emotion arousal,recovery)mixed design(N=33).Participants viewed a 4-min anxiety-inducing video followed by a 3-min scene exposure.State-Trait Anxiety Inventory-State Form(STAIS),galvanic skin response(GSR),and blood-volume pulse(BVP)frequency were analyzed with linear mixed-effects models.Experiment 2 used a 3(Motion-control mode:Unnatural,Semi-natural,Natural)×2(Sound form:Spatial positioning,Surround)×3(Experimental Phase:baseline,emotion arousal,recovery)mixed design(N=42).Presence was analyzed with the Scheirer–Ray–Hare test;phase efficacy was verified with Friedman tests.Results:Experiment 1 showed significant Scene Type×Experimental Phase interactions for GSR(F=8.006,p<0.001,η^(2)_(p)=0.624)and BVP frequency(F=11.491,p<0.001,η^(2)_(p)=0.704).VR-Wproduced the largest recovery(ΔGSR=–1.26;ΔBVP=–5.80;Hedges g≥0.83)vs.RE and VR.STAI-S returned to baseline across all Scene Types.Experiment 2 revealedmain effects of Motion-control mode(F=8.55,p=0.001,η^(2)_(p)=0.32)and Sound form(F=4.35,p=0.044,η^(2)_(p)=0.11)on Presence(Semi-natural+Spatial positioning highest).The greatest physiological recovery occurred with the UnnaturalMotioncontrolmode(GSRH=20.17,p<0.001,ε^(2)=0.49;BVPH=7.92,p=0.019),amplified by Spatial positioning Sound form only in this mode.Design factors did not influence STAI-S change.Conclusions:VR scenes are as restorative as RE;embedding VR-W accelerates recovery.Maximal Presence is not essential:Unnatural Motion-control mode induced the largest physiological recovery,especially combined with Spatial positioning Sound form.
文摘The contemporary Chinese human rights theory can be deciphered based on the "people-centered" concept. "Putting people in the center " is an approach to deve lopment,a concept of governance and a ruling orientation,and it is the idea shaping of the governing party,the ideological guideline for administrative organs and the principle of action for relevant personnel.The human rights system is thoughts,theories,systems and practice proposed by social groups and individuals to the social authority,especially the resource provider,around the basic demands for subsistence and development.Fundamentally speaking,the "people-centered" approach and the human rights system,though belonging to different political ethics and political philosophy fields,share many common points or similarities in their specific way of existence and operation process.Therefore,there is coherence between the "people-centered" approach and human rights,and there is systematic compatibility between the human rightsbased way of thinking and the people-centered governing concept.The two approaches share many commonalities in the implementation measures and actions,both requiring the integration of concepts,norms,systems and actions.The deciphering helps China to provide wisdom and marke contributions in enriching world human rights theories.
基金a periodic result of both the research project of China Society for Human Rights Studies“Research on Modern Chinese View on Human Rights”the national planned social science project“Research on Grassroots Political Stability and Its Risk Control”(19BZZ048)
文摘The right to subsistence and the right to development are the primary basic human rights,and there is a certain connection between the two.Although they refer to different things,they are mutually dependent and restricted.It is necessary to distinguish the right to development as a means and the right to development as an end.The former is the right to participate in,promote,and enjoy development,while the latter is the right of all people to enjoy free,comprehensive,and harmonious development.The protection of the right to subsistence and the right to development form an interacting virtuous cycle under certain conditions.The process of building a moderately prosperous society embodies this virtuous cycle.To build a modern socialist country in an all-round way,it is still necessary to keep on promoting the virtuous cycle between the right to subsistence and the right to development.
基金Under the auspices of National Key Research and Development Program of China(No.2023YFB4302200)National Natural Science Foundation of China(No.71831002,72174053)+1 种基金Liaoning Province Xingliao Talent Plan(No.XLYC2008030)Talent Planning in Dalian(No.2022RG05)。
文摘In the context of building a country with a strong transportation network,railway container transportation(RCT)is an important means of reducing costs,increasing efficiency,and adjusting transportation structures.Thus,its impact on regional economic development is important.Based on data from railway container-handling stations and spatial econometric models,this study discusses the differences in the development of RCT and their impact on regional economic development at different leves.This study has three main findings:first,there are significant regional differences in the development of the RCT.The intra-regional differences between the eastern and central regions of China(which do not include Hong Kong,Macao and Taiwan)are gradually narrowing,while the regional differences in the western region are widening.Meanwhile,the intra-regional differences in important economic zones such as Pearl River Delta Economic Zone(PRDEZ),Chengdu-Chongqing Economic Zone(CYEZ),Bohai Rim Economic Zone(BHEZ),and Yangtze River Delta Economic Zone(YRDEZ)are narrowing daily.Second,the development differences of RCT in regional level and important economic regions level show different trends.The unbalanced features of large regions are increasingly evident,whereas the differences in economic regions are decreasing.However,the problem of overlapping RCT remains prominent.Third,the transformation of RCT development mode and fierce competition among transportation modes cause RCT to have a restraining effect on the regional economy at three levels.Rational allocation of resources and other means must be used to guide the transformation from inhibition to promotion,and by formulating targeted policies that will promote the development of RCT,which will improve the transportation structure and help construct a country with a strong transportation system.
基金the General Project under the National Social Sci-ence Fund of China,“A Political and Philosophical Research on the Concept of a Global Community from the Perspective of the Common Values of All Mankind”(Project Approval Number 22BZX009)the Project of the Asia Research Center in Nankai University(Project Approval Number AS2120).
文摘The development of China’s human rights path is driven by both external and internal factors,influenced by general principles of human rights worldwide while also following China’s own endogenous logic.The concept of the“Two Integrations”reflects the continuous theoretical innovation of the Chinese Communist Party based on China’s national conditions,significantly illustrating the endogenous logic of China’s human rights path.Among these,the“basic principles of Marxism”occupy a“core”position within the endogenous logic of China’s human rights path,and to some extent,embody an understanding of the inherent laws of human rights.Meanwhile,“China’s specific realities”and“fine traditional Chinese culture”serve as the“living water sources”for the ongoing advancement of China’s human rights.The“Two Integrations”represent an intrinsic requirement of historical materialism and practical materialism.The logical structure of“One Core,Two Sources”explains the endogenous nature of China’s human rights path,offering both an interpretation of the driving forces behind China’s human rights path and a defense of its rationality.
基金supported by the Deanship of Research and Graduate Studies at King Khalid University through a Large Research Project under grant number RGP.2/259/45.
文摘Localization is crucial in wireless sensor networks for various applications,such as tracking objects in outdoor environments where GPS(Global Positioning System)or prior installed infrastructure is unavailable.However,traditional techniques involve many anchor nodes,increasing costs and reducing accuracy.Existing solutions do not address the selection of appropriate anchor nodes and selecting localized nodes as assistant anchor nodes for the localization process,which is a critical element in the localization process.Furthermore,an inaccurate average hop distance significantly affects localization accuracy.We propose an improved DV-Hop algorithm based on anchor sets(AS-IDV-Hop)to improve the localization accuracy.Through simulation analysis,we validated that the ASIDV-Hop proposed algorithm is more efficient in minimizing localization errors than existing studies.The ASIDV-Hop algorithm provides an efficient and cost-effective solution for localization in Wireless Sensor Networks.By strategically selecting anchor and assistant anchor nodes and rectifying the average hop distance,AS-IDV-Hop demonstrated superior performance,achieving a mean accuracy of approximately 1.59,which represents about 25.44%,38.28%,and 73.00%improvement over other algorithms,respectively.The estimated localization error is approximately 0.345,highlighting AS-IDV-Hop’s effectiveness.This substantial reduction in localization error underscores the advantages of implementing AS-IDV-Hop,particularly in complex scenarios requiring precise node localization.
基金National Natural Science Foundation of China,No.41771178, No.42030409Fundamental Research Funds for the Central Universities,No.N2111003Basic Scientific Research Project (Key Project) of the Education Department of Liaoning Province,No.LJKZ0964。
文摘Many cities face heat wave(HW) events, combined with the existent surface urban heat island(SUHI) effects. This places pressure on human settlements and sustainable development. However, few studies have investigated the SUHI effects from the perspective of HWs. In this study, the summer HWs in Beijing from 2001 to 2021 were calculated, and the evolution of HWs and SUHIs was quantitatively analyzed based on the dynamic nature of the urban-rural boundary. Beijing experienced 27 HWs in the 21 years, including 10 instances in June, four in July, and 13 in August. The SUHI varied during HWs, between 2–3℃ in most years. The highest SUHI occurred in 2019, reaching 3.99℃ and covering the largest area(10,887 km^(2)). The fluctuation in HWs and SUHIs generally displayed the same spatiotemporal pattern, and HWs amplified the SUHIs to a certain extent, with the highest correlation coefficient being 0.44. Additionally, impervious surfaces and cropland contributed most to SUHIs,and night light enhanced SUHIs. Observing the co-evolution of HWs and SUHIs will be helpful for ecological maintenance and urban infrastructure optimization and provide theoretical support for reducing heat risk and improving the human settlement environment.
基金Japan Society for the Promotion of Science(21K15614)National Natural Science Foundation of China(62103404)Chinese Academy of Sciences President’s International Fellowship Initiative(2022VBA0031).
文摘The activity of occipitotemporal regions involved in linguistic reading processes,such as the ventral occipitotemporal cortex(vOT),is believed to exhibit strong interactions during higher-order language processing,specifically in the connectivity between the occipital gyrus and the temporal gyrus.In this study,we utilized functional magnetic resonance imaging(fMRI)with psychophysiological interaction(PPI)and dynamic causal modeling(DCM)to investigate the functional and effective connectivity in the occipitotemporal network during speed reading.We conducted the experiment with native Japanese speakers who underwent and without speed-reading training and subsequently performed established reading tasks at different speeds(slow,medium,and fast)while undergoing 3-Tesla Siemens fMRI.Our activation analyses revealed significant changes in occipital and temporal regions as reading speed increased,indicating functional connectivity within the occipitotemporal network.DCM results further demonstrated more intricate effective connections and high involvement within the occipitotemporal pathway:(1)reading signals originated from the inferior occipital gyrus(iO),distributed to the vOT and the posterior superior temporal sulcus(pSTS),and then gathered in the anterior superior temporal sulcus(aSTS);(2)reading speed loads had modulation effects on the pathways from the aSTS to vOT and from the iO to vOT.These findings highlight the complex connectivity and dynamic interactions within the occipitotemporal network during speed-reading processes.
基金supported by the National Natural Science Foundation of China(82222901,82103355,and 82272619)the Innovation and Technology Fund—Guangdong–Hong Kong Technology Cooperation Funding Scheme(GHP/086/21GD)+4 种基金the Research Grants Council(RGC)Theme-based Research Scheme(T12-703/19-R)the Research Grants Council-General Research Fund(14117422 and 14117123)the Health and Medical Research Fund,Hong Kong(08191336 and 07210097)the CUHK Research Startup Fund(FPU/2023/149)the Natural Science Foundation of Fujian Province(2020J01122587).
文摘Carboxyl ester lipase(CEL),a pivotal enzyme involved in lipid metabolism,is recurrently mutated in obese mice.Here,we aimed to elucidate the functional significance,molecular mechanism,and therapeutic potential of CEL in metabolic dysfunction-associated steatohepatitis(MASH).Hepatocyte-specific carboxyl ester lipase gene(Cel)knockout(Cel^(DHEP))and wildtype(WT)littermates were fed with cholinedeficient high-fat diet(CD-HFD)for 16 weeks,or methionine-and choline-deficient diet(MCD)for three weeks to induce MASH.Liquid chromatography–mass spectrometry and co-immunoprecipitation were employed to identify the downstream targets of CEL.CD-HFD/MCD-fed WT mice received intravenous injections of CEL-adeno-associated viral,serotype 8(AAV8)to induce specific overexpression of CEL in the liver.We observed a decrease in CEL protein levels in MASH induced by CD-HFD or MCD in mice.Cel^(DHEP) mice fed with CD-HFD or MCD exhibited pronounced hepatic steatosis,inflammation,lipid peroxidation,and liver injury compared to WT littermates,accompanied by increased hepatic nuclear factor kappa-light-chain-enhancer of activated B cell(NF-jB)activation.Consistently,Cel knockdown in mouse primary hepatocytes and AML12 cells aggravated lipid accumulation and inflammation,whereas CEL overexpression exerted the opposite effect.Mechanistically,CEL directly bound to fatty acid synthase(FASN),resulting in reduced FASN SUMOylation,which in turn promoted FASN degradation through the proteasome pathway.Furthermore,inhibition of FASN ameliorated hepatocyte lipid accumulation and inflammation induced by Cel knockdown in vivo and in vitro.Hepatocyte-specific CEL overexpression using AAV8-Cel significantly mitigated steatohepatitis in mice fed with CD-HFD or MCD.CEL protects against steatohepatitis development by directly interacting with FASN and suppressing its expression for de novo lipogenesis.CEL overexpression confers a therapeutic benefit in steatohepatitis.
基金Funding was provided by the Agricultural Biotechnology Research Institute of Iran(ABRII),Swedish Research Council(Vetenskapsrådet grant no.:2017-05019)the BBSRC Institute Strategic Programme Gut Microbes and Health(BB/r012490/1,its constituent project BBS/e/F/000Pr10355).
文摘Metagenomics has opened new avenues for exploring the genetic potential of uncultured microorganisms,which may serve as promising sources of enzymes and natural products for industrial applications.Identifying enzymes with improved catalytic properties from the vast amount of available metagenomic data poses a significant challenge that demands the development of novel computational and functional screening tools.The catalytic properties of all enzymes are primarily dictated by their structures,which are predominantly determined by their amino acid sequences.However,this aspect has not been fully considered in the enzyme bioprospecting processes.With the accumulating number of available enzyme sequences and the increasing demand for discovering novel biocatalysts,structural and functional modeling can be employed to identify potential enzymes with novel catalytic properties.Recent efforts to discover new polysaccharide-degrading enzymes from rumen metagenome data using homology-based searches and machine learning-based models have shown significant promise.Here,we will explore various computational approaches that can be employed to screen and shortlist metagenome-derived enzymes as potential biocatalyst candidates,in conjunction with the wet lab analytical methods traditionally used for enzyme characterization.
基金Supported by The United States Department of Agriculture
文摘Many epidemiological and experimental studies have suggested that dietary fiber plays an important role in colon cancer prevention. These findings may relate to the ability of fiber to reduce the contact time of carcinogens within the intestinal lumen and to promote healthy gut microbiota, which modifies the host's metabolism in various ways. Elucidation of the mechanisms by which dietary fiber-dependent changes in gut microbiota enhance bile acid deconjugation, produce short chain fatty acids, and modulate inflammatory bioactive substances can lead to a better understanding of the beneficial role of dietary fiber. This article reviews the current knowledge concerning the mechanisms via which dietary fiber protects against colon cancer.
基金Project supported by the Science and Technology Project of Zhejiang Province(No.2017C32033)the National Natural Science Foundation of China(No.3127848)
文摘Royal jelly (R J)from honeybee has been widely used as a health promotion supplement.The major royal jelly proteins (MRJPs)have been identified as the functional component of RJ.However,the question of whether MRJPs have anti-senescence activity for human cells remains.Human embryonic lung fibroblast (HFL-I)cells were cultured in media containing no MRJPs (A),MRJPs at 0.1mg/ml (B),0.2mg/ml (C),or 0.3mg/ml (D),or bovine serum albumin (BSA)at 0.2mg/ml (E).The mean population doubling levels of cells in media B,C,D,and E were increased by 12.4%,31.2%,24.0%,and 10.4%,respectively,compared with that in medium A.The cells in medium C also exhibited the highest relative proliferation activity,the lowest senescence,and the longest telomeres.Moreover, MRJPs up-regulated the expression of superoxide dismutase-1(SOD1)and down-regulated the expression of mammalian target of rapamycin (MTOR),catenin beta like-1(CTNNB1),and tumor protein p53(TP53).Raman spectra analysis showed that there were two unique bands related to DNA synthesis materials,amide carbonyl group vibrations and aromatic hydrogens.These results suggest that MRJPs possess anti-senescence activity for the HFL-I cell line,and provide new knowledge illustrating the molecular mechanism of MRJPs as anti-senescence factors.
基金Project supported by the National Natural Science Foundation of China(No.31271848)the Foundation of Fuli Institute of Food Science of Zhejiang University(No.KY201404),China
文摘Turmeric residue（TR）, containing residual levels of curcumin, is a solid by-product waste generated after the extraction and separation of curcumin from turmeric root. A feeding trial was conducted to evaluate the effects of TR on the survival of Chinese soft-shelled turtles（SSTs）, Pelodiscus sinensis, under a high ambient temperature. A total of 320 female SSTs were assigned randomly to two diets： basal diet（the control group, n=160） and an interventional diet supplemented with 10% TR（the TR group, n=160）. Our results demonstrated that supplementation of TR increased the SST survival rate by 135.5%, and superoxide dismutase（SOD） activity of SST liver by 112.8%, and decreased the malondialdehyde（MDA） content of SST liver by 36.4%, compared to the control group. The skin of the SST fed TR showed a golden color. High-performance liquid chromatography（HPLC） analysis indicated that the concentrations of curcumin in TR and the skin of the SST fed TR were（1.69±0.30） and（0.14±0.03） μg/g, respectively. Our observation suggests that supplementation of TR increased the survival rate of SST under high ambient temperatures. We speculated that the increased survival rate and tolerance at the high ambient temperature were associated with the anti-oxidation activity of curcumin from TR. Moreover, curcumin in TR could be deposited in SST skin, which made it more favored in the market of China. Our findings provide new knowledge and evidence to effectively reuse TR as a feed additive in animal and aquatic farming.
基金This work was supported by Grant-in-Aid for Scientific Research (C) (No.17500119)
文摘This paper describes a multiple camera-based method to reconstruct the 3D shape of a human foot. From a foot database, an initial 3D model of the foot represented by a cloud of points is built. The shape parameters, which can characterize more than 92% of a foot, are defined by using the principal component analysis method. Then, using ＂active shape models＂, the initial 3D model is adapted to the real foot captured in multiple images by applying some constraints （edge points＇ distance and color variance）. We insist here on the experiment part where we demonstrate the efficiency of the proposed method on a plastic foot model, and also on real human feet with various shapes. We propose and compare different ways of texturing the foot which is needed for reconstruction. We present an experiment performed on the plastic foot model and on human feet and propose two different ways to improve the final 3D shapers accuracy according to the previous experiments＇ results. The first improvement proposed is the densification of the cloud of points used to represent the initial model and the foot database. The second improvement concerns the projected patterns used to texture the foot. We conclude by showing the obtained results for a human foot with the average computed shape error being only 1.06 mm.
