The contemporary Chinese human rights theory can be deciphered based on the "people-centered" concept. "Putting people in the center " is an approach to deve lopment,a concept of governance and a r...The contemporary Chinese human rights theory can be deciphered based on the "people-centered" concept. "Putting people in the center " is an approach to deve lopment,a concept of governance and a ruling orientation,and it is the idea shaping of the governing party,the ideological guideline for administrative organs and the principle of action for relevant personnel.The human rights system is thoughts,theories,systems and practice proposed by social groups and individuals to the social authority,especially the resource provider,around the basic demands for subsistence and development.Fundamentally speaking,the "people-centered" approach and the human rights system,though belonging to different political ethics and political philosophy fields,share many common points or similarities in their specific way of existence and operation process.Therefore,there is coherence between the "people-centered" approach and human rights,and there is systematic compatibility between the human rightsbased way of thinking and the people-centered governing concept.The two approaches share many commonalities in the implementation measures and actions,both requiring the integration of concepts,norms,systems and actions.The deciphering helps China to provide wisdom and marke contributions in enriching world human rights theories.展开更多
The right to subsistence and the right to development are the primary basic human rights,and there is a certain connection between the two.Although they refer to different things,they are mutually dependent and restri...The right to subsistence and the right to development are the primary basic human rights,and there is a certain connection between the two.Although they refer to different things,they are mutually dependent and restricted.It is necessary to distinguish the right to development as a means and the right to development as an end.The former is the right to participate in,promote,and enjoy development,while the latter is the right of all people to enjoy free,comprehensive,and harmonious development.The protection of the right to subsistence and the right to development form an interacting virtuous cycle under certain conditions.The process of building a moderately prosperous society embodies this virtuous cycle.To build a modern socialist country in an all-round way,it is still necessary to keep on promoting the virtuous cycle between the right to subsistence and the right to development.展开更多
Background Ongoing debates question the harm of internet use with the evolving technology,as many individuals transition from regular to problematic internet use(PIU).The habenula(Hb),located between the thalamus and ...Background Ongoing debates question the harm of internet use with the evolving technology,as many individuals transition from regular to problematic internet use(PIU).The habenula(Hb),located between the thalamus and the third ventricle,is implicated in various psychiatric disorders.In addition,personality features have been suggested to play a role in the pathophysiology of PIU.Aims This study aimed to investigate Hb volumetry in individuals with subclinical PIU and the mediating effect of personality traits on this relationship.Methods 110 healthy adults in this cross-sectional study underwent structural magnetic resonance imaging.Hb segmentation was performed using a deep learning technique.The Internet Addiction Test(IAT)and the NEO Five-Factor Inventory were used to assess the PIU level and personality,respectively.Partial Spearman's correlation analyses were performed to explore the reiationships between Hb volumetry,IAT and NEO.Multiple regression analysis was applied to identify personality traits that predict IAT scores.The significant trait was then treated as a mediator between Hb volume and IAT correlation in mediation analysis with a bootstrap value of 5000.Results Relative Hb volume was negatively correlated with IAT scores(partial rho=-0.142,p=0.009).The IAT score was positively correlated with neuroticism(partial rho=0.430,p<0.001)and negatively correlated with extraversion,agreeableness and conscientiousness(partial rho=-0.213,p<0.001;partial rho=-0.279,p<0.001;and partial rho=-0.327,p<0.001).There was a significant indirect effect of Hb volume on this model(β=-0.061,p=0.048,boot 95%confidence interval:-0.149 to-0.001).Conclusions This study uncovered a crucial link between reduced Hb volume and heightened PIU.Our findings highlight neuroticism as a key risk factor for developing PIU.Moreover,neuroticism was shown to mediate the relationship between Hb volume and PIU tendency,offering valuable insight into the complexities of this interaction.展开更多
BACKGROUND Colorectal cancer is the third most common malignancy and the fourth leading cause of cancer-related deaths worldwide.Several studies have shown an association between gut microbiota and colorectal cancer.G...BACKGROUND Colorectal cancer is the third most common malignancy and the fourth leading cause of cancer-related deaths worldwide.Several studies have shown an association between gut microbiota and colorectal cancer.Gut microbiota is unique and can be influenced by geographic factors and habits.This study aimed to determine the diversity and composition of colonic mucosal microbiota in patients with and without colorectal cancer.AIM To determine the diversity and composition of colonic mucosal microbiota in patients with and without colorectal cancer in Indonesia.METHODS This case-control study included 59 subjects(35 colorectal cancer patients and 24 non-colorectal cancer patients indicated for colonoscopy at Dr.Cipto Mangunkusumo Gastrointestinal Endoscopy Center and Fatmawati Hospital.Microbiota examination was performed using 16S rRNA sequencing.Bioinformatics analysis was performed using the wf-metagenomics pipeline from EPI2Me-Labs(Oxford Nanopore Technologies platform).RESULTS Patients with colorectal cancer had a higher median index value on the Shannon index(3.28 vs 2.82,P>0.05)and a lower value on the Simpson index(0.050 vs 0.060,P>0.05).Significant differences in beta diversity were observed at the genus(P=0.002)and species levels(P=0.001).Firmicutes,Proteobacteria,Bacteroidetes,and Fusobacteria were the dominant phyla.The genera Bacteroides,Campylobacter,Peptostreptococcus,and Parvimonas were found more frequently in colorectal cancer,while Faecalibacterium,Haemophilus,and Phocaeicola were more frequently found in non-colorectal cancer.The relative abundance of Fusobacterium nucleatum,Bacteroides fragilis,Enterococcus faecalis,Campylobacter hominis,and Enterococcus faecalis species was significantly elevated in patients with colorectal cancer.Meanwhile,Faecalibacterium prausnitzii,Faecalibacterium duncaniae,and Prevotella copri were more commonly found in non-colorectal cancer.CONCLUSION Patients with colorectal cancer exhibit distinct differences in the composition and diversity of their colonic mucosal microbiota compared to those with non-colorectal cancer.This study was reviewed and approved by the Ethics Committee of Faculty of Medicine,Universitas Indonesia(No.KET-1517/UN2.F1/ETIK/PPM.00.02/2023).展开更多
To adapt to national climate change strategies,understanding the thermal vulnerability of urban functional zones(UFZs)is critical for enhancing the livability and sustainable development of cities.We address the limit...To adapt to national climate change strategies,understanding the thermal vulnerability of urban functional zones(UFZs)is critical for enhancing the livability and sustainable development of cities.We address the limitations of existing thermal vulnerability assessments by incorporating human perception into the analysis.Specifically,we introduce the sky openness index to reflect human perception of the thermal environment and examine variations in thermal vulnerability across different UFZs.Using the Extreme Gradient Boosting(XGBoost)-SHapley Additive exPlanations(SHAP)model,we analyze the contributions of 2D and 3D urban form indicators to thermal vulnerability and link these contributions to the unique needs and vulnerability characteristics of UFZs of Foshan City,China in 2023.The results reveal that:1)high-value heat-fragile areas(1.74–2.00]constitute 10.42%of Foshan City;2)traffic zone and publiccommercial zone exhibit the highest levels of thermal vulnerability;and 3)building height and the normalized building index are the most influential factors,with contributions of|0.06|and|0.03|,respectively.We provide a scientific foundation for developing governance strategies to promote urban resilience.展开更多
Objectives:Emotional stress is a significant public health challenge.Virtual reality(VR)offers the potential for aiding emotional recovery.This study explores the impact of VR environment design factors on emotional r...Objectives:Emotional stress is a significant public health challenge.Virtual reality(VR)offers the potential for aiding emotional recovery.This study explores the impact of VR environment design factors on emotional recovery,examining underlying mechanisms through physiological indicators and behavioral responses.Methods:Two experimentswere conducted.Experiment 1 employed a 4[Scene Type:real environment(RE),virtual scenes that restore the RE(VR),virtual scenes that incorporate natural window view design(VR-W),and a no-scene control condition(CTL)]×3(Experimental Phase:baseline,emotion arousal,recovery)mixed design(N=33).Participants viewed a 4-min anxiety-inducing video followed by a 3-min scene exposure.State-Trait Anxiety Inventory-State Form(STAIS),galvanic skin response(GSR),and blood-volume pulse(BVP)frequency were analyzed with linear mixed-effects models.Experiment 2 used a 3(Motion-control mode:Unnatural,Semi-natural,Natural)×2(Sound form:Spatial positioning,Surround)×3(Experimental Phase:baseline,emotion arousal,recovery)mixed design(N=42).Presence was analyzed with the Scheirer–Ray–Hare test;phase efficacy was verified with Friedman tests.Results:Experiment 1 showed significant Scene Type×Experimental Phase interactions for GSR(F=8.006,p<0.001,η^(2)_(p)=0.624)and BVP frequency(F=11.491,p<0.001,η^(2)_(p)=0.704).VR-Wproduced the largest recovery(ΔGSR=–1.26;ΔBVP=–5.80;Hedges g≥0.83)vs.RE and VR.STAI-S returned to baseline across all Scene Types.Experiment 2 revealedmain effects of Motion-control mode(F=8.55,p=0.001,η^(2)_(p)=0.32)and Sound form(F=4.35,p=0.044,η^(2)_(p)=0.11)on Presence(Semi-natural+Spatial positioning highest).The greatest physiological recovery occurred with the UnnaturalMotioncontrolmode(GSRH=20.17,p<0.001,ε^(2)=0.49;BVPH=7.92,p=0.019),amplified by Spatial positioning Sound form only in this mode.Design factors did not influence STAI-S change.Conclusions:VR scenes are as restorative as RE;embedding VR-W accelerates recovery.Maximal Presence is not essential:Unnatural Motion-control mode induced the largest physiological recovery,especially combined with Spatial positioning Sound form.展开更多
Many epidemiological and experimental studies have suggested that dietary fiber plays an important role in colon cancer prevention. These findings may relate to the ability of fiber to reduce the contact time of carci...Many epidemiological and experimental studies have suggested that dietary fiber plays an important role in colon cancer prevention. These findings may relate to the ability of fiber to reduce the contact time of carcinogens within the intestinal lumen and to promote healthy gut microbiota, which modifies the host's metabolism in various ways. Elucidation of the mechanisms by which dietary fiber-dependent changes in gut microbiota enhance bile acid deconjugation, produce short chain fatty acids, and modulate inflammatory bioactive substances can lead to a better understanding of the beneficial role of dietary fiber. This article reviews the current knowledge concerning the mechanisms via which dietary fiber protects against colon cancer.展开更多
Royal jelly (R J)from honeybee has been widely used as a health promotion supplement.The major royal jelly proteins (MRJPs)have been identified as the functional component of RJ.However,the question of whether MRJPs h...Royal jelly (R J)from honeybee has been widely used as a health promotion supplement.The major royal jelly proteins (MRJPs)have been identified as the functional component of RJ.However,the question of whether MRJPs have anti-senescence activity for human cells remains.Human embryonic lung fibroblast (HFL-I)cells were cultured in media containing no MRJPs (A),MRJPs at 0.1mg/ml (B),0.2mg/ml (C),or 0.3mg/ml (D),or bovine serum albumin (BSA)at 0.2mg/ml (E).The mean population doubling levels of cells in media B,C,D,and E were increased by 12.4%,31.2%,24.0%,and 10.4%,respectively,compared with that in medium A.The cells in medium C also exhibited the highest relative proliferation activity,the lowest senescence,and the longest telomeres.Moreover, MRJPs up-regulated the expression of superoxide dismutase-1(SOD1)and down-regulated the expression of mammalian target of rapamycin (MTOR),catenin beta like-1(CTNNB1),and tumor protein p53(TP53).Raman spectra analysis showed that there were two unique bands related to DNA synthesis materials,amide carbonyl group vibrations and aromatic hydrogens.These results suggest that MRJPs possess anti-senescence activity for the HFL-I cell line,and provide new knowledge illustrating the molecular mechanism of MRJPs as anti-senescence factors.展开更多
Turmeric residue（TR）, containing residual levels of curcumin, is a solid by-product waste generated after the extraction and separation of curcumin from turmeric root. A feeding trial was conducted to evaluate the e...Turmeric residue（TR）, containing residual levels of curcumin, is a solid by-product waste generated after the extraction and separation of curcumin from turmeric root. A feeding trial was conducted to evaluate the effects of TR on the survival of Chinese soft-shelled turtles（SSTs）, Pelodiscus sinensis, under a high ambient temperature. A total of 320 female SSTs were assigned randomly to two diets： basal diet（the control group, n=160） and an interventional diet supplemented with 10% TR（the TR group, n=160）. Our results demonstrated that supplementation of TR increased the SST survival rate by 135.5%, and superoxide dismutase（SOD） activity of SST liver by 112.8%, and decreased the malondialdehyde（MDA） content of SST liver by 36.4%, compared to the control group. The skin of the SST fed TR showed a golden color. High-performance liquid chromatography（HPLC） analysis indicated that the concentrations of curcumin in TR and the skin of the SST fed TR were（1.69±0.30） and（0.14±0.03） μg/g, respectively. Our observation suggests that supplementation of TR increased the survival rate of SST under high ambient temperatures. We speculated that the increased survival rate and tolerance at the high ambient temperature were associated with the anti-oxidation activity of curcumin from TR. Moreover, curcumin in TR could be deposited in SST skin, which made it more favored in the market of China. Our findings provide new knowledge and evidence to effectively reuse TR as a feed additive in animal and aquatic farming.展开更多
This paper studies the relationship between accessibility and housing prices in Dalian by using an improved geographically weighted regression model and house prices, traffic, remote sensing images, etc. Multi-source ...This paper studies the relationship between accessibility and housing prices in Dalian by using an improved geographically weighted regression model and house prices, traffic, remote sensing images, etc. Multi-source data improves the accuracy of the spatial differentiation that reflects the impact of traffic accessibility on house prices. The results are as follows: first, the average house price is 12 436 yuan(RMB)/m^2, and reveals a declining trend from coastal areas to inland areas. The exception was Guilin Street, which demonstrates a local peak of house prices that decreases from the center of the street to its periphery. Second, the accessibility value is 33 minutes on average, excluding northern and eastern fringe areas, which was over 50 minutes. Third, the significant spatial correlation coefficient between accessibility and house prices is 0.423, and the coefficient increases in the southeastern direction. The strongest impact of accessibility on house prices is in the southeastern coast, and can be seen in the Lehua, Yingke, and Hushan communities, while the weakest impact is in the northwestern fringe, and can be seen in the Yingchengzi, Xixiaomo, and Daheishi community areas.展开更多
The major royal jelly proteins(MRJPs)are the central constituents responsible for the specific activities of royal jelly.Here MRJPs via oral administration daily for 45 consecutive days were evaluated the effects on t...The major royal jelly proteins(MRJPs)are the central constituents responsible for the specific activities of royal jelly.Here MRJPs via oral administration daily for 45 consecutive days were evaluated the effects on the reproductive parameters in immature female mice(FM).Neonatal FM were divided into four groups fed MRJPs with doses of 0,125,250 and 500 mg/kg/body weight(M125,M250 and M500).The results in M125,M250 and M500 showed that the times of estrus were accelerated by 10.7%,15.5%and 10.7%,the secondary follicles number were increased by 50.7%,78.8%and 38.6%,the Graafian follicles were increased by 600.0%and 774.0%and 150.0%,respectively.M500 induced multi-oocyte follicles.The serum estradiol levels of the three groups were increased by 47.1%,64.9%and 31.1%,the action of MRJPs raising hormone secretion level is mainly via upregulating expression of ERˇgene.Antioxidant parameters of ovarian tissue showed that the malondialdehyde levels in M125 and M250 were decreased,the superoxide dismutase activities and glutathione peroxidase activities in M125 and M250 were increased.In conclusion,MRJPs may accelerate onset of puberty and promote follicular development in FM.Our findings would facilitate better understanding of the benefit effect of MRJPs as the key ingredient in royal jelly on promoting fertility performance.展开更多
The distribution of repetitive DNAs along chromosomes is one of the crucial elements for understanding the organization and the evolution of plant genomes.Using a modified genomic in situ hybridization(GISH)procedure,...The distribution of repetitive DNAs along chromosomes is one of the crucial elements for understanding the organization and the evolution of plant genomes.Using a modified genomic in situ hybridization(GISH)procedure,fluorescence in situ hybridization(FISH)with genomic DNA to their own chromosomes(called self-genomic in situ hybridization,self-GISH)was carried out in six selected plant species with different genome size and amount of repetitive DNA.Nonuniform distribution of the fluorescent labeled probe DNA was observed on the chromosomes of all the species that were tested.The signal patterns varied among species and were related to the genome size.The chromosomes of the small Arabidopsis genome were labeled almost only in the pericentromeric regions and the nucleolus organizer regions(NORs).The signals in the relatively small genomes,rice,sorghum,and Brassica oleracea var.capitata L.,were dispersed along the chromosome lengths,with a predominant distribution in the pericentromeric or proximal regions and some heterochromatic arms.All chromosomes of the large genomes,maize and barley,were densely labeled with strongly labeled regions and weakly labeled or unlabeled regions being arranged alternatively throughout the lengths.In addition,enhanced signal bands were shown in all pericentromeres and the NORs in B.oleracea var.capitata,and in all pericentromeric regions and certain intercalary sites in barley.The enhanced signal band pattern in barley was found consistent with the N-banding pattern of this species.The GISH with self-genomic DNA was compared with FISH with Cot-1 DNA in rice,and their signal patterns are found to be basically consistent.Our results showed that the self-GISH signals actually reflected the hybridization of genomic repetitive DNAs to the chromosomes,thus the self-GISH technique would be useful for revealing the distribution of the regions where repetitive DNAs concentrate along chromosomes and some chromatin differentiation associated with repetitive DNAs in plants.展开更多
This paper describes a multiple camera-based method to reconstruct the 3D shape of a human foot. From a foot database, an initial 3D model of the foot represented by a cloud of points is built. The shape parameters, w...This paper describes a multiple camera-based method to reconstruct the 3D shape of a human foot. From a foot database, an initial 3D model of the foot represented by a cloud of points is built. The shape parameters, which can characterize more than 92% of a foot, are defined by using the principal component analysis method. Then, using ＂active shape models＂, the initial 3D model is adapted to the real foot captured in multiple images by applying some constraints （edge points＇ distance and color variance）. We insist here on the experiment part where we demonstrate the efficiency of the proposed method on a plastic foot model, and also on real human feet with various shapes. We propose and compare different ways of texturing the foot which is needed for reconstruction. We present an experiment performed on the plastic foot model and on human feet and propose two different ways to improve the final 3D shapers accuracy according to the previous experiments＇ results. The first improvement proposed is the densification of the cloud of points used to represent the initial model and the foot database. The second improvement concerns the projected patterns used to texture the foot. We conclude by showing the obtained results for a human foot with the average computed shape error being only 1.06 mm.展开更多
In the context of building a country with a strong transportation network,railway container transportation(RCT)is an important means of reducing costs,increasing efficiency,and adjusting transportation structures.Thus...In the context of building a country with a strong transportation network,railway container transportation(RCT)is an important means of reducing costs,increasing efficiency,and adjusting transportation structures.Thus,its impact on regional economic development is important.Based on data from railway container-handling stations and spatial econometric models,this study discusses the differences in the development of RCT and their impact on regional economic development at different leves.This study has three main findings:first,there are significant regional differences in the development of the RCT.The intra-regional differences between the eastern and central regions of China(which do not include Hong Kong,Macao and Taiwan)are gradually narrowing,while the regional differences in the western region are widening.Meanwhile,the intra-regional differences in important economic zones such as Pearl River Delta Economic Zone(PRDEZ),Chengdu-Chongqing Economic Zone(CYEZ),Bohai Rim Economic Zone(BHEZ),and Yangtze River Delta Economic Zone(YRDEZ)are narrowing daily.Second,the development differences of RCT in regional level and important economic regions level show different trends.The unbalanced features of large regions are increasingly evident,whereas the differences in economic regions are decreasing.However,the problem of overlapping RCT remains prominent.Third,the transformation of RCT development mode and fierce competition among transportation modes cause RCT to have a restraining effect on the regional economy at three levels.Rational allocation of resources and other means must be used to guide the transformation from inhibition to promotion,and by formulating targeted policies that will promote the development of RCT,which will improve the transportation structure and help construct a country with a strong transportation system.展开更多
Even though mutations in LMNA have been reported in patients with typical dilated cardio-myopathy(DCM)and atrioventricular block(AVB)previously,the purpose of this study was to disclose this novel genetic abnormality ...Even though mutations in LMNA have been reported in patients with typical dilated cardio-myopathy(DCM)and atrioventricular block(AVB)previously,the purpose of this study was to disclose this novel genetic abnormality in one Chinese family with the atypical phenotype of progressive AVB followed by DCM with normal QRS interval.Genome-wide linkage analysis mapped the AVB gene in this family to a marker at chromosome 1q21.2,where the LMNA gene was located.Direct DNA sequence analysis revealed a heterozygous G t...展开更多
We investigated the relationships between the existence of exercise partners and exercise habits among Japanese university students. Subjects were 650 university students (539 males, 111 females;age range 18 - 27 year...We investigated the relationships between the existence of exercise partners and exercise habits among Japanese university students. Subjects were 650 university students (539 males, 111 females;age range 18 - 27 years). They responded to an anonymous questionnaire asking about current and past exercise habits, preference for exercise (i.e., like or dislike of exercise), and the existence of one or more exercise partners. In the results, the existence of exercise partners had a significant association with exercise habits at each school stage in both genders. Exercise preference had a significant association with exercise habits during high school in both genders;during primary and middle school, however, this association was significant only in males. In males, exercise habits and the preference for exercising in high school affected current exercise habits. In females, only exercise habits in high school affected current exercise habits. Our results suggest that the existence of one or more exercise partners is important for the practice of exercise, as well as the preference for exercise. They also suggest that continuity of exercise habits is different between males and females.展开更多
Background: Animal studies have demonstrated that iron may be related to carcinogenesis, and human studies found that heme iron can increase the formation of Nnitroso compounds, which are known carcinogens. Objectives...Background: Animal studies have demonstrated that iron may be related to carcinogenesis, and human studies found that heme iron can increase the formation of Nnitroso compounds, which are known carcinogens. Objectives: One of the postulated mechanisms linking red meat intake to cancer risk involves iron. Epidemiologic studies attempt to investigate the association between heme iron intake and cancer by applying a standard factor to total iron from meat. However, laboratory studies suggest that heme iron levels in meat vary according to cooking method and doneness level. We measured heme iron in meats cooked by different cooking methods to a range of doneness levels to use in conjunction with a food frequency questionnaire to estimate heme iron intake. Methods: Composite meat samples were made to represent each meat type, cooking method and doneness level. Heme iron was measured using atomic absorption spectrometry and inductively coupled plasma-atomic emission spectrometry. Results: Steak and hamburgers contained the highest levels of heme iron, pork and chicken thigh meat had slightly lower levels, and chicken breast meat had the lowest. Conclusions: Although heme iron levels varied, there was no clear effect of cooking method or doneness level. We outline the methods used to create a heme iron database to be used in conjunction with food frequency questionnaires to estimate heme iron intake in relation to disease outcome.展开更多
文摘The contemporary Chinese human rights theory can be deciphered based on the "people-centered" concept. "Putting people in the center " is an approach to deve lopment,a concept of governance and a ruling orientation,and it is the idea shaping of the governing party,the ideological guideline for administrative organs and the principle of action for relevant personnel.The human rights system is thoughts,theories,systems and practice proposed by social groups and individuals to the social authority,especially the resource provider,around the basic demands for subsistence and development.Fundamentally speaking,the "people-centered" approach and the human rights system,though belonging to different political ethics and political philosophy fields,share many common points or similarities in their specific way of existence and operation process.Therefore,there is coherence between the "people-centered" approach and human rights,and there is systematic compatibility between the human rightsbased way of thinking and the people-centered governing concept.The two approaches share many commonalities in the implementation measures and actions,both requiring the integration of concepts,norms,systems and actions.The deciphering helps China to provide wisdom and marke contributions in enriching world human rights theories.
基金a periodic result of both the research project of China Society for Human Rights Studies“Research on Modern Chinese View on Human Rights”the national planned social science project“Research on Grassroots Political Stability and Its Risk Control”(19BZZ048)
文摘The right to subsistence and the right to development are the primary basic human rights,and there is a certain connection between the two.Although they refer to different things,they are mutually dependent and restricted.It is necessary to distinguish the right to development as a means and the right to development as an end.The former is the right to participate in,promote,and enjoy development,while the latter is the right of all people to enjoy free,comprehensive,and harmonious development.The protection of the right to subsistence and the right to development form an interacting virtuous cycle under certain conditions.The process of building a moderately prosperous society embodies this virtuous cycle.To build a modern socialist country in an all-round way,it is still necessary to keep on promoting the virtuous cycle between the right to subsistence and the right to development.
基金funded by a Grant-in-Aid for Scientific Research(B)(Japan Society for The Promotion of Science,21H02849)Grant-in-Aid for Scientific Research(C)(Japan Society for The Promotion of Science,23K07013)+2 种基金Grant-in-Aid for Transformative Research Areas(A)(Japan Society for The Promotion of Science,JP21H05173)Grant-in-Aid by the Smoking Research FoundationGrant-in-Aid by the Telecommunications Advancement Foundation.
文摘Background Ongoing debates question the harm of internet use with the evolving technology,as many individuals transition from regular to problematic internet use(PIU).The habenula(Hb),located between the thalamus and the third ventricle,is implicated in various psychiatric disorders.In addition,personality features have been suggested to play a role in the pathophysiology of PIU.Aims This study aimed to investigate Hb volumetry in individuals with subclinical PIU and the mediating effect of personality traits on this relationship.Methods 110 healthy adults in this cross-sectional study underwent structural magnetic resonance imaging.Hb segmentation was performed using a deep learning technique.The Internet Addiction Test(IAT)and the NEO Five-Factor Inventory were used to assess the PIU level and personality,respectively.Partial Spearman's correlation analyses were performed to explore the reiationships between Hb volumetry,IAT and NEO.Multiple regression analysis was applied to identify personality traits that predict IAT scores.The significant trait was then treated as a mediator between Hb volume and IAT correlation in mediation analysis with a bootstrap value of 5000.Results Relative Hb volume was negatively correlated with IAT scores(partial rho=-0.142,p=0.009).The IAT score was positively correlated with neuroticism(partial rho=0.430,p<0.001)and negatively correlated with extraversion,agreeableness and conscientiousness(partial rho=-0.213,p<0.001;partial rho=-0.279,p<0.001;and partial rho=-0.327,p<0.001).There was a significant indirect effect of Hb volume on this model(β=-0.061,p=0.048,boot 95%confidence interval:-0.149 to-0.001).Conclusions This study uncovered a crucial link between reduced Hb volume and heightened PIU.Our findings highlight neuroticism as a key risk factor for developing PIU.Moreover,neuroticism was shown to mediate the relationship between Hb volume and PIU tendency,offering valuable insight into the complexities of this interaction.
文摘BACKGROUND Colorectal cancer is the third most common malignancy and the fourth leading cause of cancer-related deaths worldwide.Several studies have shown an association between gut microbiota and colorectal cancer.Gut microbiota is unique and can be influenced by geographic factors and habits.This study aimed to determine the diversity and composition of colonic mucosal microbiota in patients with and without colorectal cancer.AIM To determine the diversity and composition of colonic mucosal microbiota in patients with and without colorectal cancer in Indonesia.METHODS This case-control study included 59 subjects(35 colorectal cancer patients and 24 non-colorectal cancer patients indicated for colonoscopy at Dr.Cipto Mangunkusumo Gastrointestinal Endoscopy Center and Fatmawati Hospital.Microbiota examination was performed using 16S rRNA sequencing.Bioinformatics analysis was performed using the wf-metagenomics pipeline from EPI2Me-Labs(Oxford Nanopore Technologies platform).RESULTS Patients with colorectal cancer had a higher median index value on the Shannon index(3.28 vs 2.82,P>0.05)and a lower value on the Simpson index(0.050 vs 0.060,P>0.05).Significant differences in beta diversity were observed at the genus(P=0.002)and species levels(P=0.001).Firmicutes,Proteobacteria,Bacteroidetes,and Fusobacteria were the dominant phyla.The genera Bacteroides,Campylobacter,Peptostreptococcus,and Parvimonas were found more frequently in colorectal cancer,while Faecalibacterium,Haemophilus,and Phocaeicola were more frequently found in non-colorectal cancer.The relative abundance of Fusobacterium nucleatum,Bacteroides fragilis,Enterococcus faecalis,Campylobacter hominis,and Enterococcus faecalis species was significantly elevated in patients with colorectal cancer.Meanwhile,Faecalibacterium prausnitzii,Faecalibacterium duncaniae,and Prevotella copri were more commonly found in non-colorectal cancer.CONCLUSION Patients with colorectal cancer exhibit distinct differences in the composition and diversity of their colonic mucosal microbiota compared to those with non-colorectal cancer.This study was reviewed and approved by the Ethics Committee of Faculty of Medicine,Universitas Indonesia(No.KET-1517/UN2.F1/ETIK/PPM.00.02/2023).
基金Under the auspices of Liaoning Revitalization Talents Program(No.XLYC2202024)Basic Scientific Research Project(Key Project)of the Education Department of Liaoning Province(No.LJ212410165084)the Fundamental Research Funds for the Central Universities(No.N2111003,N2411001)。
文摘To adapt to national climate change strategies,understanding the thermal vulnerability of urban functional zones(UFZs)is critical for enhancing the livability and sustainable development of cities.We address the limitations of existing thermal vulnerability assessments by incorporating human perception into the analysis.Specifically,we introduce the sky openness index to reflect human perception of the thermal environment and examine variations in thermal vulnerability across different UFZs.Using the Extreme Gradient Boosting(XGBoost)-SHapley Additive exPlanations(SHAP)model,we analyze the contributions of 2D and 3D urban form indicators to thermal vulnerability and link these contributions to the unique needs and vulnerability characteristics of UFZs of Foshan City,China in 2023.The results reveal that:1)high-value heat-fragile areas(1.74–2.00]constitute 10.42%of Foshan City;2)traffic zone and publiccommercial zone exhibit the highest levels of thermal vulnerability;and 3)building height and the normalized building index are the most influential factors,with contributions of|0.06|and|0.03|,respectively.We provide a scientific foundation for developing governance strategies to promote urban resilience.
基金funded by the General Project of the National Social Science Fund(NSSF)of China in Art(Project No.23BG133)the Scientific Research Foundation ofWuhan Institute of Technology(Project No.K2023064)+2 种基金the Open Fund of Key Research Base of Humanities and Social Sciences in Hubei Province—Research Center for College Students’Development and Innovation Education:“VR Healing Intervention for College Students’Academic Anxiety—VR Healing Based on Intention Dialogue”(Project No.DXS2023017)the Research Project of China Youth and Children Research Society(Project No.2025B11)the Major Strategic Consulting Projects of the Chinese Academy of Engineering between Academy and Local Regions(Project No.2024-DFZD-41).
文摘Objectives:Emotional stress is a significant public health challenge.Virtual reality(VR)offers the potential for aiding emotional recovery.This study explores the impact of VR environment design factors on emotional recovery,examining underlying mechanisms through physiological indicators and behavioral responses.Methods:Two experimentswere conducted.Experiment 1 employed a 4[Scene Type:real environment(RE),virtual scenes that restore the RE(VR),virtual scenes that incorporate natural window view design(VR-W),and a no-scene control condition(CTL)]×3(Experimental Phase:baseline,emotion arousal,recovery)mixed design(N=33).Participants viewed a 4-min anxiety-inducing video followed by a 3-min scene exposure.State-Trait Anxiety Inventory-State Form(STAIS),galvanic skin response(GSR),and blood-volume pulse(BVP)frequency were analyzed with linear mixed-effects models.Experiment 2 used a 3(Motion-control mode:Unnatural,Semi-natural,Natural)×2(Sound form:Spatial positioning,Surround)×3(Experimental Phase:baseline,emotion arousal,recovery)mixed design(N=42).Presence was analyzed with the Scheirer–Ray–Hare test;phase efficacy was verified with Friedman tests.Results:Experiment 1 showed significant Scene Type×Experimental Phase interactions for GSR(F=8.006,p<0.001,η^(2)_(p)=0.624)and BVP frequency(F=11.491,p<0.001,η^(2)_(p)=0.704).VR-Wproduced the largest recovery(ΔGSR=–1.26;ΔBVP=–5.80;Hedges g≥0.83)vs.RE and VR.STAI-S returned to baseline across all Scene Types.Experiment 2 revealedmain effects of Motion-control mode(F=8.55,p=0.001,η^(2)_(p)=0.32)and Sound form(F=4.35,p=0.044,η^(2)_(p)=0.11)on Presence(Semi-natural+Spatial positioning highest).The greatest physiological recovery occurred with the UnnaturalMotioncontrolmode(GSRH=20.17,p<0.001,ε^(2)=0.49;BVPH=7.92,p=0.019),amplified by Spatial positioning Sound form only in this mode.Design factors did not influence STAI-S change.Conclusions:VR scenes are as restorative as RE;embedding VR-W accelerates recovery.Maximal Presence is not essential:Unnatural Motion-control mode induced the largest physiological recovery,especially combined with Spatial positioning Sound form.
基金Supported by The United States Department of Agriculture
文摘Many epidemiological and experimental studies have suggested that dietary fiber plays an important role in colon cancer prevention. These findings may relate to the ability of fiber to reduce the contact time of carcinogens within the intestinal lumen and to promote healthy gut microbiota, which modifies the host's metabolism in various ways. Elucidation of the mechanisms by which dietary fiber-dependent changes in gut microbiota enhance bile acid deconjugation, produce short chain fatty acids, and modulate inflammatory bioactive substances can lead to a better understanding of the beneficial role of dietary fiber. This article reviews the current knowledge concerning the mechanisms via which dietary fiber protects against colon cancer.
基金Project supported by the Science and Technology Project of Zhejiang Province(No.2017C32033)the National Natural Science Foundation of China(No.3127848)
文摘Royal jelly (R J)from honeybee has been widely used as a health promotion supplement.The major royal jelly proteins (MRJPs)have been identified as the functional component of RJ.However,the question of whether MRJPs have anti-senescence activity for human cells remains.Human embryonic lung fibroblast (HFL-I)cells were cultured in media containing no MRJPs (A),MRJPs at 0.1mg/ml (B),0.2mg/ml (C),or 0.3mg/ml (D),or bovine serum albumin (BSA)at 0.2mg/ml (E).The mean population doubling levels of cells in media B,C,D,and E were increased by 12.4%,31.2%,24.0%,and 10.4%,respectively,compared with that in medium A.The cells in medium C also exhibited the highest relative proliferation activity,the lowest senescence,and the longest telomeres.Moreover, MRJPs up-regulated the expression of superoxide dismutase-1(SOD1)and down-regulated the expression of mammalian target of rapamycin (MTOR),catenin beta like-1(CTNNB1),and tumor protein p53(TP53).Raman spectra analysis showed that there were two unique bands related to DNA synthesis materials,amide carbonyl group vibrations and aromatic hydrogens.These results suggest that MRJPs possess anti-senescence activity for the HFL-I cell line,and provide new knowledge illustrating the molecular mechanism of MRJPs as anti-senescence factors.
基金Project supported by the National Natural Science Foundation of China(No.31271848)the Foundation of Fuli Institute of Food Science of Zhejiang University(No.KY201404),China
文摘Turmeric residue（TR）, containing residual levels of curcumin, is a solid by-product waste generated after the extraction and separation of curcumin from turmeric root. A feeding trial was conducted to evaluate the effects of TR on the survival of Chinese soft-shelled turtles（SSTs）, Pelodiscus sinensis, under a high ambient temperature. A total of 320 female SSTs were assigned randomly to two diets： basal diet（the control group, n=160） and an interventional diet supplemented with 10% TR（the TR group, n=160）. Our results demonstrated that supplementation of TR increased the SST survival rate by 135.5%, and superoxide dismutase（SOD） activity of SST liver by 112.8%, and decreased the malondialdehyde（MDA） content of SST liver by 36.4%, compared to the control group. The skin of the SST fed TR showed a golden color. High-performance liquid chromatography（HPLC） analysis indicated that the concentrations of curcumin in TR and the skin of the SST fed TR were（1.69±0.30） and（0.14±0.03） μg/g, respectively. Our observation suggests that supplementation of TR increased the survival rate of SST under high ambient temperatures. We speculated that the increased survival rate and tolerance at the high ambient temperature were associated with the anti-oxidation activity of curcumin from TR. Moreover, curcumin in TR could be deposited in SST skin, which made it more favored in the market of China. Our findings provide new knowledge and evidence to effectively reuse TR as a feed additive in animal and aquatic farming.
基金Under the auspices of National Natural Science Foundation of China(No.41471140,41771178)Liaoning Province Outstanding Youth Program(No.LJQ2015058)
文摘This paper studies the relationship between accessibility and housing prices in Dalian by using an improved geographically weighted regression model and house prices, traffic, remote sensing images, etc. Multi-source data improves the accuracy of the spatial differentiation that reflects the impact of traffic accessibility on house prices. The results are as follows: first, the average house price is 12 436 yuan(RMB)/m^2, and reveals a declining trend from coastal areas to inland areas. The exception was Guilin Street, which demonstrates a local peak of house prices that decreases from the center of the street to its periphery. Second, the accessibility value is 33 minutes on average, excluding northern and eastern fringe areas, which was over 50 minutes. Third, the significant spatial correlation coefficient between accessibility and house prices is 0.423, and the coefficient increases in the southeastern direction. The strongest impact of accessibility on house prices is in the southeastern coast, and can be seen in the Lehua, Yingke, and Hushan communities, while the weakest impact is in the northwestern fringe, and can be seen in the Yingchengzi, Xixiaomo, and Daheishi community areas.
基金The authors are grateful to Dr.Quanwei Wei from Nanjing Agricultural University,Nanjing,China for his technical assistance.This work was supported by the National Natural Science Foundation of China(no.31271848)。
文摘The major royal jelly proteins(MRJPs)are the central constituents responsible for the specific activities of royal jelly.Here MRJPs via oral administration daily for 45 consecutive days were evaluated the effects on the reproductive parameters in immature female mice(FM).Neonatal FM were divided into four groups fed MRJPs with doses of 0,125,250 and 500 mg/kg/body weight(M125,M250 and M500).The results in M125,M250 and M500 showed that the times of estrus were accelerated by 10.7%,15.5%and 10.7%,the secondary follicles number were increased by 50.7%,78.8%and 38.6%,the Graafian follicles were increased by 600.0%and 774.0%and 150.0%,respectively.M500 induced multi-oocyte follicles.The serum estradiol levels of the three groups were increased by 47.1%,64.9%and 31.1%,the action of MRJPs raising hormone secretion level is mainly via upregulating expression of ERˇgene.Antioxidant parameters of ovarian tissue showed that the malondialdehyde levels in M125 and M250 were decreased,the superoxide dismutase activities and glutathione peroxidase activities in M125 and M250 were increased.In conclusion,MRJPs may accelerate onset of puberty and promote follicular development in FM.Our findings would facilitate better understanding of the benefit effect of MRJPs as the key ingredient in royal jelly on promoting fertility performance.
基金This work was supported by the National Natural Sciences Foundation of China(No.39870423).
文摘The distribution of repetitive DNAs along chromosomes is one of the crucial elements for understanding the organization and the evolution of plant genomes.Using a modified genomic in situ hybridization(GISH)procedure,fluorescence in situ hybridization(FISH)with genomic DNA to their own chromosomes(called self-genomic in situ hybridization,self-GISH)was carried out in six selected plant species with different genome size and amount of repetitive DNA.Nonuniform distribution of the fluorescent labeled probe DNA was observed on the chromosomes of all the species that were tested.The signal patterns varied among species and were related to the genome size.The chromosomes of the small Arabidopsis genome were labeled almost only in the pericentromeric regions and the nucleolus organizer regions(NORs).The signals in the relatively small genomes,rice,sorghum,and Brassica oleracea var.capitata L.,were dispersed along the chromosome lengths,with a predominant distribution in the pericentromeric or proximal regions and some heterochromatic arms.All chromosomes of the large genomes,maize and barley,were densely labeled with strongly labeled regions and weakly labeled or unlabeled regions being arranged alternatively throughout the lengths.In addition,enhanced signal bands were shown in all pericentromeres and the NORs in B.oleracea var.capitata,and in all pericentromeric regions and certain intercalary sites in barley.The enhanced signal band pattern in barley was found consistent with the N-banding pattern of this species.The GISH with self-genomic DNA was compared with FISH with Cot-1 DNA in rice,and their signal patterns are found to be basically consistent.Our results showed that the self-GISH signals actually reflected the hybridization of genomic repetitive DNAs to the chromosomes,thus the self-GISH technique would be useful for revealing the distribution of the regions where repetitive DNAs concentrate along chromosomes and some chromatin differentiation associated with repetitive DNAs in plants.
基金This work was supported by Grant-in-Aid for Scientific Research (C) (No.17500119)
文摘This paper describes a multiple camera-based method to reconstruct the 3D shape of a human foot. From a foot database, an initial 3D model of the foot represented by a cloud of points is built. The shape parameters, which can characterize more than 92% of a foot, are defined by using the principal component analysis method. Then, using ＂active shape models＂, the initial 3D model is adapted to the real foot captured in multiple images by applying some constraints （edge points＇ distance and color variance）. We insist here on the experiment part where we demonstrate the efficiency of the proposed method on a plastic foot model, and also on real human feet with various shapes. We propose and compare different ways of texturing the foot which is needed for reconstruction. We present an experiment performed on the plastic foot model and on human feet and propose two different ways to improve the final 3D shapers accuracy according to the previous experiments＇ results. The first improvement proposed is the densification of the cloud of points used to represent the initial model and the foot database. The second improvement concerns the projected patterns used to texture the foot. We conclude by showing the obtained results for a human foot with the average computed shape error being only 1.06 mm.
基金Under the auspices of National Key Research and Development Program of China(No.2023YFB4302200)National Natural Science Foundation of China(No.71831002,72174053)+1 种基金Liaoning Province Xingliao Talent Plan(No.XLYC2008030)Talent Planning in Dalian(No.2022RG05)。
文摘In the context of building a country with a strong transportation network,railway container transportation(RCT)is an important means of reducing costs,increasing efficiency,and adjusting transportation structures.Thus,its impact on regional economic development is important.Based on data from railway container-handling stations and spatial econometric models,this study discusses the differences in the development of RCT and their impact on regional economic development at different leves.This study has three main findings:first,there are significant regional differences in the development of the RCT.The intra-regional differences between the eastern and central regions of China(which do not include Hong Kong,Macao and Taiwan)are gradually narrowing,while the regional differences in the western region are widening.Meanwhile,the intra-regional differences in important economic zones such as Pearl River Delta Economic Zone(PRDEZ),Chengdu-Chongqing Economic Zone(CYEZ),Bohai Rim Economic Zone(BHEZ),and Yangtze River Delta Economic Zone(YRDEZ)are narrowing daily.Second,the development differences of RCT in regional level and important economic regions level show different trends.The unbalanced features of large regions are increasingly evident,whereas the differences in economic regions are decreasing.However,the problem of overlapping RCT remains prominent.Third,the transformation of RCT development mode and fierce competition among transportation modes cause RCT to have a restraining effect on the regional economy at three levels.Rational allocation of resources and other means must be used to guide the transformation from inhibition to promotion,and by formulating targeted policies that will promote the development of RCT,which will improve the transportation structure and help construct a country with a strong transportation system.
文摘Even though mutations in LMNA have been reported in patients with typical dilated cardio-myopathy(DCM)and atrioventricular block(AVB)previously,the purpose of this study was to disclose this novel genetic abnormality in one Chinese family with the atypical phenotype of progressive AVB followed by DCM with normal QRS interval.Genome-wide linkage analysis mapped the AVB gene in this family to a marker at chromosome 1q21.2,where the LMNA gene was located.Direct DNA sequence analysis revealed a heterozygous G t...
文摘We investigated the relationships between the existence of exercise partners and exercise habits among Japanese university students. Subjects were 650 university students (539 males, 111 females;age range 18 - 27 years). They responded to an anonymous questionnaire asking about current and past exercise habits, preference for exercise (i.e., like or dislike of exercise), and the existence of one or more exercise partners. In the results, the existence of exercise partners had a significant association with exercise habits at each school stage in both genders. Exercise preference had a significant association with exercise habits during high school in both genders;during primary and middle school, however, this association was significant only in males. In males, exercise habits and the preference for exercising in high school affected current exercise habits. In females, only exercise habits in high school affected current exercise habits. Our results suggest that the existence of one or more exercise partners is important for the practice of exercise, as well as the preference for exercise. They also suggest that continuity of exercise habits is different between males and females.
文摘Background: Animal studies have demonstrated that iron may be related to carcinogenesis, and human studies found that heme iron can increase the formation of Nnitroso compounds, which are known carcinogens. Objectives: One of the postulated mechanisms linking red meat intake to cancer risk involves iron. Epidemiologic studies attempt to investigate the association between heme iron intake and cancer by applying a standard factor to total iron from meat. However, laboratory studies suggest that heme iron levels in meat vary according to cooking method and doneness level. We measured heme iron in meats cooked by different cooking methods to a range of doneness levels to use in conjunction with a food frequency questionnaire to estimate heme iron intake. Methods: Composite meat samples were made to represent each meat type, cooking method and doneness level. Heme iron was measured using atomic absorption spectrometry and inductively coupled plasma-atomic emission spectrometry. Results: Steak and hamburgers contained the highest levels of heme iron, pork and chicken thigh meat had slightly lower levels, and chicken breast meat had the lowest. Conclusions: Although heme iron levels varied, there was no clear effect of cooking method or doneness level. We outline the methods used to create a heme iron database to be used in conjunction with food frequency questionnaires to estimate heme iron intake in relation to disease outcome.
