The improved granular mixtures are widely used as the fillings of railway 8ubgrade, and in order to investigate the effect of coarse grain content on granular mixtures, a series of field tests were conducted. The expe...The improved granular mixtures are widely used as the fillings of railway 8ubgrade, and in order to investigate the effect of coarse grain content on granular mixtures, a series of field tests were conducted. The experimental results indicate that the permeability coefficient increases significantly with the increment of granite gravel content, especially in the range of 60%-70%. Thcrc exists a coarse grain content limit defined as 53%-58.5% to reform the permeable granular skeleton. Beyond this limit, the permeable granular skeleton is efficiently formed, and the macro pores between the separate gravels are partially filled, which is the explanation lbr the permeability increase. The investigations indicate the subgrade resistance modulus （ks0, Ev2, and Evd） depends on the granite gravel content, and the resistance modulus increases significantly beyond granite gravel content of 50%. The skeletons of granitc gravel clayey sand mixture change in the long-term deformation objected to the train-induced dynamic load, which involves three main repeated and circular deformation stages. Generally, the long-time deformation is explained as the gravel crushing and filling the internal porous space with crushed gravel fragments. Through these investigations, the C40-G60 or C30-G70 is recommended as an optimum soil mixture for the good permeability and high resistance modulus.展开更多
Noise pollution is a major hazardous factor to human health and is likely harmful for vulnerable groups such as pre-term infants under lifesupport system in an intensive care unit. Previous studies have suggested that...Noise pollution is a major hazardous factor to human health and is likely harmful for vulnerable groups such as pre-term infants under lifesupport system in an intensive care unit. Previous studies have suggested that noise exposure impairs children’s learning ability and cognitive performance and cognitive functions in animal models in which the effect is mainly attributed to the oxidant stress of noise on the cognitive brain. The potential role of noise induced hearing loss(NIHL), rather than the oxidant stress, has also been indicated by a depression of neurogenesis in the hippocampus long after a brief noise exposure, which produces only a tentative oxidant stress. It is not clear if noise exposure and NIHL during early development exerts a long term impact on cognitive function and neurogenesis towards adulthood. In the present study, a brief noise exposure at high sound level was performed in neonatal C57BL/6J mice(15 days after birth) to produce a significant amount of permanent hearing loss as proved 2 months after the noise. At this age, the noise-exposed animals showed deteriorated spatial learning and memory abilities and a reduction of hippocampal neurogenesis as compared with the control. The averaged hearing threshold was found to be strongly correlated with the scores for spatial learning and memory. We consider the effects observed are largely due to the loss of hearing sensitivity, rather than the oxidant stress, due to the long interval between noise exposure and the observations.展开更多
We examined the neural correlates of the statistical learning of orthographic-semantic connections in Chinese adult learners.Visual event-related potentials(ERPs) were recorded while participants were exposed to a seq...We examined the neural correlates of the statistical learning of orthographic-semantic connections in Chinese adult learners.Visual event-related potentials(ERPs) were recorded while participants were exposed to a sequence of artificial logographic characters containing semantic radicals carrying low,moderate,or high levels of semantic consistency.The behavioral results showed that the mean accuracy of participants’ recognition of previously exposed characters was 63.1% that was significantly above chance level(50%),indicating the statistical learning of the regularities of semantic radicals.The ERP data revealed a temporal sequence of the neural process of statistical learning of orthographic-semantic connections,and different brain indexes were found to be associated with this processing,i.e.,a clear N170-P200-N400 pattern.For N170,the larger negative amplitudes were evoked by the high and moderate consistency than the low consistency.For P200,the mean amplitudes elicited by the moderate and low consistency were larger than the high consistency.In contrast,a larger N400 amplitude was observed in the low than moderate and high consistency;and more negative amplitude was elicited by the moderate than high consistency.We propose that the initial potential shifts(N170 and P200) may reflect orthographic or graphic form identification,while the later component(N400) may be associated with semantic information analysis.展开更多
New coronavirus disease(COVID-19)has constituted a global pandemic and has spread to most countries and regions in the world.Through understanding the development trend of confirmed cases in a region,the government ca...New coronavirus disease(COVID-19)has constituted a global pandemic and has spread to most countries and regions in the world.Through understanding the development trend of confirmed cases in a region,the government can control the pandemic by using the corresponding policies.However,the common traditional mathematical differential equations and population prediction models have limitations for time series population prediction,and even have large estimation errors.To address this issue,we propose an improved method for predicting confirmed cases based on LSTM(Long-Short Term Memory)neural network.This work compares the deviation between the experimental results of the improved LSTM prediction model and the digital prediction models(such as Logistic and Hill equations)with the real data as reference.Furthermore,this work uses the goodness of fitting to evaluate the fitting effect of the improvement.Experiments show that the proposed approach has a smaller prediction deviation and a better fitting effect.Compared with the previous forecasting methods,the contributions of our proposed improvement methods are mainly in the following aspects:1)we have fully considered the spatiotemporal characteristics of the data,rather than single standardized data.2)the improved parameter settings and evaluation indicators are more accurate for fitting and forecasting.3)we consider the impact of the epidemic stage and conduct reasonable data processing for different stage.展开更多
The study on scientific analysis and prediction of China’s future carbon emissions is conducive to balancing the relationship between economic development and carbon emissions in the new era,and actively responding t...The study on scientific analysis and prediction of China’s future carbon emissions is conducive to balancing the relationship between economic development and carbon emissions in the new era,and actively responding to climate change policy.Through the analysis of the application of the generalized regression neural network(GRNN)in prediction,this paper improved the prediction method of GRNN.Genetic algorithm(GA)was adopted to search the optimal smooth factor as the only factor of GRNN,which was then used for prediction in GRNN.During the prediction of carbon dioxide emissions using the improved method,the increments of data were taken into account.The target values were obtained after the calculation of the predicted results.Finally,compared with the results of GRNN,the improved method realized higher prediction accuracy.It thus offers a new way of predicting total carbon dioxide emissions,and the prediction results can provide macroscopic guidance and decision-making reference for China’s environmental protection and trading of carbon emissions.展开更多
Optical chaos has attracted widespread attention owing to its complex dynamic behaviors.However,the time delay signature(TDS)caused by the external cavity mode reduces the complexity of optical chaos.We propose and nu...Optical chaos has attracted widespread attention owing to its complex dynamic behaviors.However,the time delay signature(TDS)caused by the external cavity mode reduces the complexity of optical chaos.We propose and numerically demonstrate the critical dispersion of chirped fiber Bragg grating(CFBG)for eliminating the TDS of laser chaos in this work.The critical dispersion,as a function of relaxation frequency and bandwidth of the optical spectrum,is found through extensive dynamics simulations.It is shown that the TDS can be eliminated when the dispersion of CFBG is above this critical dispersion.In addition,the influence of dispersive feedback light and output light from a laser is investigated.These results provide important quantitative guidance for designing chaotic semiconductor lasers without TDS.展开更多
In the end of 1970s,China’s East Asian novels in Chinese began to attract Chinese scholars’attention.Since 1980s,the study of foreign novels in Chinese has become the focus of the Chinese scholars.A lot of scholars ...In the end of 1970s,China’s East Asian novels in Chinese began to attract Chinese scholars’attention.Since 1980s,the study of foreign novels in Chinese has become the focus of the Chinese scholars.A lot of scholars in Taiwan and the Mainland have deepened this study in different ways.inclu.ding document collection and literature review,the study of texts and the cultural research,and have ob-tained a series of remarkable academic achievements.Therefore,this article,as a general review of the re-search achievements from the 1980s,aims to study the present emendation and research situation of East A-sian novels in Chinese and interpret the academic significance deeply.展开更多
Background: This article traces the history of scientific ideas connecting forest cover with rainfall to inform ongoing debates about whether forests are net users or producers of water in the hydrological cycle. Scho...Background: This article traces the history of scientific ideas connecting forest cover with rainfall to inform ongoing debates about whether forests are net users or producers of water in the hydrological cycle. Scholars of the supply-side school argue that forests are net producers and magnifiers that increase rainfall at regional scales. Supply-side scholars seek to challenge the dominance of demand-side thinking. The demand-side school emphasizes that trees are net users of water within a catchment that decrease overall water available for other users. This scientific debate has significant implications for the development of policies to manage forests and water. Results: Scientists have debated the question of whether forests improve or worsen water balance for over two hundred years. Connections between forests and rainfall gained prominence in scientific circles during the second half of the nineteenth century and again during the past three decades. The popularity of forest- rainfall connections has paralleled societal and scientific interest in anthropogenic climate change and deforestation. Theories connecting forests with rainfall peaked in popularity in the 1850s to 1880s, a period when scientists expressed alarm that deforestation caused regional declines in precipitation. Forests were understood to create rain within a locality and region. Scientific consensus shifted by the early twentieth century to the view that forests did not play a significant role in determining rainfall. The forest-rainfall connection reemerged in the 1980s alongside advances in climate modelling and growing fears of anthropogenic global warming and tropical deforestation. Using new data and theories, supply-side advocates have once again placed a strong forest-rainfall connection into scientific prominence. Conclusion: Supply-side management policies have a checkered history that should elicit caution, while demand-side policies, which are based on almost a century of hydrological research, should not be overturned quickly in regions that face potential water scarcity before more research is conducted.展开更多
Background: Excessive daytime sleepiness (EDS) is common in adults. A need exists for an easier and faster objective clinical measures of EDS. The autonomic nervous system controls pupil size and prior pupillometry st...Background: Excessive daytime sleepiness (EDS) is common in adults. A need exists for an easier and faster objective clinical measures of EDS. The autonomic nervous system controls pupil size and prior pupillometry studies have demonstrated associations with sleepiness. We used a novel portable device to assess pupillometry and prospectively evaluated a sleep clinic cohort. Methods: Following IRB approval Pupillometry (The ForSiteTM, NeurOptics, Irvine, CA), was performed on 113 sleep clinic patients. Constriction and dilation velocity and latencies, minimum and maximum aperture were obtained along with Epworth Sleepiness Score (ESS), 10 point Visual Analog Scale (VAS), BMI, gender, age and AHI. Three sets of measures were obtained and analyzed with ANOVA, t-test, Linear Regression and Pearson correlation coefficients (SAS, Cary, NC). Results: Both constriction velocity and latency correlated with VAS (n = 88, r = 0.28, p = 0.007 and r = 0.31, p = 0.004). Only constriction velocity correlated with AHI (n = 78, r = -0.27, p = 0.016). Multivariate linear regression which includes VAS and age predicted constriction velocity (r = 0.36, p = 0.002) and latency (r = 0.38, p = 0.001). Using Pearson correlation, AHI and VAS combined were associated with constriction velocity (-0.273 (0.016), and 0.284 (0.007), respectively). Using a maximum constriction velocity threshold value (age adjusted) of 2.8, VAS ≥ 6 was predicted with a sensitivity of 83% and specificity of 84%. Conclusions: Pupillary constriction velocity and latency predict self-reported VAS state of sleepiness. While both are affected by age, only constriction velocity is affected by apnea severity. These data suggest that a portable pupillometer may provide a method to identify individuals with abnormal sleepiness.展开更多
This paper mainly discusses verbal aspects and their syntactic markers in Lhasa Tibetan. Since aspects in Tibetan always share markers with other important categories called evidentiality and egocentricity, the former...This paper mainly discusses verbal aspects and their syntactic markers in Lhasa Tibetan. Since aspects in Tibetan always share markers with other important categories called evidentiality and egocentricity, the former of which assesses the evidence of speaker's statement and the latter denotes behavioral characteristics of a speaker'sego-centricity, this paper simultaneously describes all three types: aspect, evidentiality and egocentricity. There are nine types of verb aspects in Lhasa Tibetan, namely: Prospective, Imminent, Premediated, Realis, Durative, Resultative, Merely-past, Perfect, and Contextual aspects. There are four types of evidentialities, namely, Self-knowledge, Knowing-by-sight, Knowing-by-newly-found-information and Knowing-by-inference evidentialities. Categories of egocentricity demonstrate whether an action is towards the Self or the Other, whether the speaker gains or loses, and so on. Additionally, this essay also discusses the interactive relationship between syntactical verb aspects and personal pronouns, intentionality, modality, as well as temporal-spatial cognition.展开更多
Zebrafish have the potential to regrow injured organs and tissues,but their use as a model for hearing regeneration following blast injury has never been reported.In this study,zebrafish were exposed to a blast wave p...Zebrafish have the potential to regrow injured organs and tissues,but their use as a model for hearing regeneration following blast injury has never been reported.In this study,zebrafish were exposed to a blast wave produced by an underwater blast wave generator.The first peak sound pressures produced by this generator were up to 224dB and 160kPa,measured at 25cm away from the machine.Zebrafish hearing sensitivity was examined by analyzing auditory evoked potentials from 1 to 35 days post blast wave exposure.Cell death and cell proliferation in inner ear organs,including the saccule,lagena,and utricle,were investigated using a terminal deoxynucleotidyl transferase deoxyuridine triphosphate nick-end labeling assay,and cell proliferation assay using 5-ethynyl-20-deoxyuridine,respectively.Significant differences in auditory evoked potential thresholds were observed between exposed and control groups,demonstrating both blast wave-induced hearing loss and recovery of hearing sensitivity.An apoptosis assay revealed significantly increased numbers of terminal deoxynucleotidyl transferase deoxyuridine triphosphate nick-end labelingpositive cells in the inner ear sensory epithelia of exposed groups compared with the control group.However,numbers of 5-ethynyl-20-deoxyuridine-positive cells in the inner ear of exposed groups recovered to a normal level within 10 post blast wave exposure.Furthermore,blast wave exposure caused brain injury with increased cell apoptosis and decreased neurogenesis.Compared with drug or noise-induced zebrafish models,our blast wave-induced model elicited more serious hearing loss phenotypes,which required more time to return to a normal level.Overall,this zebrafish model can provide a reliable animal model for both hearing loss and regeneration research.The study was approved by the Shanghai 6th Hospital Animal Care and Use Committee,China(approval No.2017-0196)on February 28,2017.展开更多
A fundamental difference among modern languages in the world are made by word-syllable structures(WSS), not by distinctive phonemes. Language diversity is supposed to be an evolutionary result of the WSSs, which is de...A fundamental difference among modern languages in the world are made by word-syllable structures(WSS), not by distinctive phonemes. Language diversity is supposed to be an evolutionary result of the WSSs, which is decided by types of syllable constitution and the length of word by syllables. Here we use Swadesh lists of 179 modern languages to analyze their geographic distribution of WSS diversity index and try to discover their developing positions and depths in the evolutionary processes. We also set an ideal WSS offset model for languages, calculate the offset distance and offset direction of each language, and then divide languages into three groups according to the data result, each of which represents an evolutionary type. Our conclusion is that the WSS diversity and the WSS offset model represent the evolutionary trend of diversity and the evolutionary process of human languages in the world. In addition, every language nowadays keeps the most primary WSS features to some extent. Therefore, the WSS may be regarded as genetic factors of human languages.展开更多
基金Project(51378514)supported by the National Natural Science Foundation of China
文摘The improved granular mixtures are widely used as the fillings of railway 8ubgrade, and in order to investigate the effect of coarse grain content on granular mixtures, a series of field tests were conducted. The experimental results indicate that the permeability coefficient increases significantly with the increment of granite gravel content, especially in the range of 60%-70%. Thcrc exists a coarse grain content limit defined as 53%-58.5% to reform the permeable granular skeleton. Beyond this limit, the permeable granular skeleton is efficiently formed, and the macro pores between the separate gravels are partially filled, which is the explanation lbr the permeability increase. The investigations indicate the subgrade resistance modulus （ks0, Ev2, and Evd） depends on the granite gravel content, and the resistance modulus increases significantly beyond granite gravel content of 50%. The skeletons of granitc gravel clayey sand mixture change in the long-term deformation objected to the train-induced dynamic load, which involves three main repeated and circular deformation stages. Generally, the long-time deformation is explained as the gravel crushing and filling the internal porous space with crushed gravel fragments. Through these investigations, the C40-G60 or C30-G70 is recommended as an optimum soil mixture for the good permeability and high resistance modulus.
基金supported by a grant from Nature Science Foundation of China (Grant#:81272086)
文摘Noise pollution is a major hazardous factor to human health and is likely harmful for vulnerable groups such as pre-term infants under lifesupport system in an intensive care unit. Previous studies have suggested that noise exposure impairs children’s learning ability and cognitive performance and cognitive functions in animal models in which the effect is mainly attributed to the oxidant stress of noise on the cognitive brain. The potential role of noise induced hearing loss(NIHL), rather than the oxidant stress, has also been indicated by a depression of neurogenesis in the hippocampus long after a brief noise exposure, which produces only a tentative oxidant stress. It is not clear if noise exposure and NIHL during early development exerts a long term impact on cognitive function and neurogenesis towards adulthood. In the present study, a brief noise exposure at high sound level was performed in neonatal C57BL/6J mice(15 days after birth) to produce a significant amount of permanent hearing loss as proved 2 months after the noise. At this age, the noise-exposed animals showed deteriorated spatial learning and memory abilities and a reduction of hippocampal neurogenesis as compared with the control. The averaged hearing threshold was found to be strongly correlated with the scores for spatial learning and memory. We consider the effects observed are largely due to the loss of hearing sensitivity, rather than the oxidant stress, due to the long interval between noise exposure and the observations.
基金supported,in part,by the General Research Fund of the Hong Kong Government Research Grant Council(17609518)the Early Career Scheme of the Hong Kong Grants Council (28606419)the National Natural Science Foundation of China (31600903)。
文摘We examined the neural correlates of the statistical learning of orthographic-semantic connections in Chinese adult learners.Visual event-related potentials(ERPs) were recorded while participants were exposed to a sequence of artificial logographic characters containing semantic radicals carrying low,moderate,or high levels of semantic consistency.The behavioral results showed that the mean accuracy of participants’ recognition of previously exposed characters was 63.1% that was significantly above chance level(50%),indicating the statistical learning of the regularities of semantic radicals.The ERP data revealed a temporal sequence of the neural process of statistical learning of orthographic-semantic connections,and different brain indexes were found to be associated with this processing,i.e.,a clear N170-P200-N400 pattern.For N170,the larger negative amplitudes were evoked by the high and moderate consistency than the low consistency.For P200,the mean amplitudes elicited by the moderate and low consistency were larger than the high consistency.In contrast,a larger N400 amplitude was observed in the low than moderate and high consistency;and more negative amplitude was elicited by the moderate than high consistency.We propose that the initial potential shifts(N170 and P200) may reflect orthographic or graphic form identification,while the later component(N400) may be associated with semantic information analysis.
基金This work was supported by the Hainan Provincial Natural Science Foundation of China[2018CXTD333,617048]National Natural Science Foundation of China[61762033,61702539]+3 种基金Hainan University Doctor Start Fund Project[kyqd1328]Hainan University Youth Fund Project[qnjj1444]Ministry of Education Humanities and Social Sciences Research Program Fund Project[19YJA710010]the Opening Project of Shanghai Trusted Industrial Control Platform.
文摘New coronavirus disease(COVID-19)has constituted a global pandemic and has spread to most countries and regions in the world.Through understanding the development trend of confirmed cases in a region,the government can control the pandemic by using the corresponding policies.However,the common traditional mathematical differential equations and population prediction models have limitations for time series population prediction,and even have large estimation errors.To address this issue,we propose an improved method for predicting confirmed cases based on LSTM(Long-Short Term Memory)neural network.This work compares the deviation between the experimental results of the improved LSTM prediction model and the digital prediction models(such as Logistic and Hill equations)with the real data as reference.Furthermore,this work uses the goodness of fitting to evaluate the fitting effect of the improvement.Experiments show that the proposed approach has a smaller prediction deviation and a better fitting effect.Compared with the previous forecasting methods,the contributions of our proposed improvement methods are mainly in the following aspects:1)we have fully considered the spatiotemporal characteristics of the data,rather than single standardized data.2)the improved parameter settings and evaluation indicators are more accurate for fitting and forecasting.3)we consider the impact of the epidemic stage and conduct reasonable data processing for different stage.
文摘The study on scientific analysis and prediction of China’s future carbon emissions is conducive to balancing the relationship between economic development and carbon emissions in the new era,and actively responding to climate change policy.Through the analysis of the application of the generalized regression neural network(GRNN)in prediction,this paper improved the prediction method of GRNN.Genetic algorithm(GA)was adopted to search the optimal smooth factor as the only factor of GRNN,which was then used for prediction in GRNN.During the prediction of carbon dioxide emissions using the improved method,the increments of data were taken into account.The target values were obtained after the calculation of the predicted results.Finally,compared with the results of GRNN,the improved method realized higher prediction accuracy.It thus offers a new way of predicting total carbon dioxide emissions,and the prediction results can provide macroscopic guidance and decision-making reference for China’s environmental protection and trading of carbon emissions.
基金the National Natural Science Foundation of China(Grant No.62105190)the Natural Science Foundation of Shanxi Province of China(Grant No.20210302124268)+1 种基金the Scientific and Technological Innovation Programs of Higher Education Institutions of Shanxi Province of China(Grant No.2021L285)the Youth Researchof Shanxi University of Finance and Economics(Grant No.QN-202015)。
文摘Optical chaos has attracted widespread attention owing to its complex dynamic behaviors.However,the time delay signature(TDS)caused by the external cavity mode reduces the complexity of optical chaos.We propose and numerically demonstrate the critical dispersion of chirped fiber Bragg grating(CFBG)for eliminating the TDS of laser chaos in this work.The critical dispersion,as a function of relaxation frequency and bandwidth of the optical spectrum,is found through extensive dynamics simulations.It is shown that the TDS can be eliminated when the dispersion of CFBG is above this critical dispersion.In addition,the influence of dispersive feedback light and output light from a laser is investigated.These results provide important quantitative guidance for designing chaotic semiconductor lasers without TDS.
文摘In the end of 1970s,China’s East Asian novels in Chinese began to attract Chinese scholars’attention.Since 1980s,the study of foreign novels in Chinese has become the focus of the Chinese scholars.A lot of scholars in Taiwan and the Mainland have deepened this study in different ways.inclu.ding document collection and literature review,the study of texts and the cultural research,and have ob-tained a series of remarkable academic achievements.Therefore,this article,as a general review of the re-search achievements from the 1980s,aims to study the present emendation and research situation of East A-sian novels in Chinese and interpret the academic significance deeply.
基金funding from the Australian Research Council for the Discovery Project grant,“Saving the world the first time:global climate theory and desiccation 1765-1960”DP110104024
文摘Background: This article traces the history of scientific ideas connecting forest cover with rainfall to inform ongoing debates about whether forests are net users or producers of water in the hydrological cycle. Scholars of the supply-side school argue that forests are net producers and magnifiers that increase rainfall at regional scales. Supply-side scholars seek to challenge the dominance of demand-side thinking. The demand-side school emphasizes that trees are net users of water within a catchment that decrease overall water available for other users. This scientific debate has significant implications for the development of policies to manage forests and water. Results: Scientists have debated the question of whether forests improve or worsen water balance for over two hundred years. Connections between forests and rainfall gained prominence in scientific circles during the second half of the nineteenth century and again during the past three decades. The popularity of forest- rainfall connections has paralleled societal and scientific interest in anthropogenic climate change and deforestation. Theories connecting forests with rainfall peaked in popularity in the 1850s to 1880s, a period when scientists expressed alarm that deforestation caused regional declines in precipitation. Forests were understood to create rain within a locality and region. Scientific consensus shifted by the early twentieth century to the view that forests did not play a significant role in determining rainfall. The forest-rainfall connection reemerged in the 1980s alongside advances in climate modelling and growing fears of anthropogenic global warming and tropical deforestation. Using new data and theories, supply-side advocates have once again placed a strong forest-rainfall connection into scientific prominence. Conclusion: Supply-side management policies have a checkered history that should elicit caution, while demand-side policies, which are based on almost a century of hydrological research, should not be overturned quickly in regions that face potential water scarcity before more research is conducted.
文摘Background: Excessive daytime sleepiness (EDS) is common in adults. A need exists for an easier and faster objective clinical measures of EDS. The autonomic nervous system controls pupil size and prior pupillometry studies have demonstrated associations with sleepiness. We used a novel portable device to assess pupillometry and prospectively evaluated a sleep clinic cohort. Methods: Following IRB approval Pupillometry (The ForSiteTM, NeurOptics, Irvine, CA), was performed on 113 sleep clinic patients. Constriction and dilation velocity and latencies, minimum and maximum aperture were obtained along with Epworth Sleepiness Score (ESS), 10 point Visual Analog Scale (VAS), BMI, gender, age and AHI. Three sets of measures were obtained and analyzed with ANOVA, t-test, Linear Regression and Pearson correlation coefficients (SAS, Cary, NC). Results: Both constriction velocity and latency correlated with VAS (n = 88, r = 0.28, p = 0.007 and r = 0.31, p = 0.004). Only constriction velocity correlated with AHI (n = 78, r = -0.27, p = 0.016). Multivariate linear regression which includes VAS and age predicted constriction velocity (r = 0.36, p = 0.002) and latency (r = 0.38, p = 0.001). Using Pearson correlation, AHI and VAS combined were associated with constriction velocity (-0.273 (0.016), and 0.284 (0.007), respectively). Using a maximum constriction velocity threshold value (age adjusted) of 2.8, VAS ≥ 6 was predicted with a sensitivity of 83% and specificity of 84%. Conclusions: Pupillary constriction velocity and latency predict self-reported VAS state of sleepiness. While both are affected by age, only constriction velocity is affected by apnea severity. These data suggest that a portable pupillometer may provide a method to identify individuals with abnormal sleepiness.
基金This study is sponsored by the National Natural Science foundation of China (Number 60173024,60473135). We thank Professors Sun Tianxin, J. L. Randy, J. A. Matisoff and Gu Yang for theirconstructive comments.
文摘This paper mainly discusses verbal aspects and their syntactic markers in Lhasa Tibetan. Since aspects in Tibetan always share markers with other important categories called evidentiality and egocentricity, the former of which assesses the evidence of speaker's statement and the latter denotes behavioral characteristics of a speaker'sego-centricity, this paper simultaneously describes all three types: aspect, evidentiality and egocentricity. There are nine types of verb aspects in Lhasa Tibetan, namely: Prospective, Imminent, Premediated, Realis, Durative, Resultative, Merely-past, Perfect, and Contextual aspects. There are four types of evidentialities, namely, Self-knowledge, Knowing-by-sight, Knowing-by-newly-found-information and Knowing-by-inference evidentialities. Categories of egocentricity demonstrate whether an action is towards the Self or the Other, whether the speaker gains or loses, and so on. Additionally, this essay also discusses the interactive relationship between syntactical verb aspects and personal pronouns, intentionality, modality, as well as temporal-spatial cognition.
基金the State Key Program of National Natural Science Foundation of China(No.81530029 to SY)International Cooperation and Exchange of the National Natural Science Foundation of China(No.8171001156 to SY)+1 种基金National Natural Science Foundation of China(No.81771007 to JW)the Major Program of Shanghai Committee of Science and Technology of China(No.14DJ1400202 to SY).
文摘Zebrafish have the potential to regrow injured organs and tissues,but their use as a model for hearing regeneration following blast injury has never been reported.In this study,zebrafish were exposed to a blast wave produced by an underwater blast wave generator.The first peak sound pressures produced by this generator were up to 224dB and 160kPa,measured at 25cm away from the machine.Zebrafish hearing sensitivity was examined by analyzing auditory evoked potentials from 1 to 35 days post blast wave exposure.Cell death and cell proliferation in inner ear organs,including the saccule,lagena,and utricle,were investigated using a terminal deoxynucleotidyl transferase deoxyuridine triphosphate nick-end labeling assay,and cell proliferation assay using 5-ethynyl-20-deoxyuridine,respectively.Significant differences in auditory evoked potential thresholds were observed between exposed and control groups,demonstrating both blast wave-induced hearing loss and recovery of hearing sensitivity.An apoptosis assay revealed significantly increased numbers of terminal deoxynucleotidyl transferase deoxyuridine triphosphate nick-end labelingpositive cells in the inner ear sensory epithelia of exposed groups compared with the control group.However,numbers of 5-ethynyl-20-deoxyuridine-positive cells in the inner ear of exposed groups recovered to a normal level within 10 post blast wave exposure.Furthermore,blast wave exposure caused brain injury with increased cell apoptosis and decreased neurogenesis.Compared with drug or noise-induced zebrafish models,our blast wave-induced model elicited more serious hearing loss phenotypes,which required more time to return to a normal level.Overall,this zebrafish model can provide a reliable animal model for both hearing loss and regeneration research.The study was approved by the Shanghai 6th Hospital Animal Care and Use Committee,China(approval No.2017-0196)on February 28,2017.
基金supported by the National Natural Science Fundation of China (31271337)the National Social Science Foundation of China (12&ZD174)
文摘A fundamental difference among modern languages in the world are made by word-syllable structures(WSS), not by distinctive phonemes. Language diversity is supposed to be an evolutionary result of the WSSs, which is decided by types of syllable constitution and the length of word by syllables. Here we use Swadesh lists of 179 modern languages to analyze their geographic distribution of WSS diversity index and try to discover their developing positions and depths in the evolutionary processes. We also set an ideal WSS offset model for languages, calculate the offset distance and offset direction of each language, and then divide languages into three groups according to the data result, each of which represents an evolutionary type. Our conclusion is that the WSS diversity and the WSS offset model represent the evolutionary trend of diversity and the evolutionary process of human languages in the world. In addition, every language nowadays keeps the most primary WSS features to some extent. Therefore, the WSS may be regarded as genetic factors of human languages.
