Human spinal cord organoids(hSCOs)offer a promising platform to study neurotrauma by addressing many limitations of traditional research models.These organoids provide access to human-specific physiological and geneti...Human spinal cord organoids(hSCOs)offer a promising platform to study neurotrauma by addressing many limitations of traditional research models.These organoids provide access to human-specific physiological and genetic mechanisms and can be derived from an individual's somatic cells(e.g.,blood or skin).This enables patient-specific paradigms for precision neurotrauma research,pa rticula rly relevant to the over 300,000 people in the United States living with chronic effects of spinal cord injury(SCI).展开更多
BACKGROUND To prevent mother to child transmission(MTCT)of human immunodeficiency virus(HIV),sustained maternal viral load suppression(VLS)and early HIV testing among HIV exposed infants(HEI)is critical.AIM To investi...BACKGROUND To prevent mother to child transmission(MTCT)of human immunodeficiency virus(HIV),sustained maternal viral load suppression(VLS)and early HIV testing among HIV exposed infants(HEI)is critical.AIM To investigate maternal viral load results and infant HIV testing uptake at 6-weeks,and 9-months and 18-months in Rwanda.METHODS Between 2015 and 2022,VLS(<200 copies/mL)was measured among pregnant women living with HIV(WLHIV)from 38-healthcare facilities.Viral loads(VL)were measured at 6-months,12-months and 24-months,respectively.For maternal VL,the unit of analysis was visit-pair,and the pairs were created to define those with VL<200 copies/mL at two consecutive visits as having sustained VLS,persistent viremia(VL≥200 copies/mL at two consecutive visits),viral rebound(VL<200 copies/mL at prior visit only)and newly suppressed(VL<200 copies/mL at subsequent visit only).HEI were considered to have persistent HIV testing if they had all three HIV tests.Poisson regression models with generalized estimating equations were used to estimate the adjusted incidence rate ratio(aIRR)and 95%CI for factors associated with sustained VLS and persistent HIV testing.RESULTS A total of 1145 mother-infant pairs were analyzed.Infant HIV testing uptake at 6-weeks,9-months and 18-months was 1145(100.0%),1089(95.1%),1006(87.9%)respectively.Nine hundred ninety-nine HEI(87.3%)tested for HIV persistently.At 18-months,the incidence of HIV among HEI was 8(0.7%).Of 1145 mothers,1076(94.0%)had≥2 VL results making a total of 2010 visit-pairs(142-single;934-double visit-pairs).The incidence rate of sustained VLS,persistent viremia,viral rebound and new suppression were 91.0%,1.3%,3.6%and 4.0%respectively.Maternal disclosure of HIV status(aIRR=1.08,95%CI:1.02-1.14)was associated with increased likelihood of sustained VLS.Having peer support(aIRR=1.0595%CI:1.01-1.10)was associated with persistent HIV testing among HEI.CONCLUSION Sustained VLS is high among pregnant WLHIV in Rwanda.The low incidence of HIV among HEI may be attributed to high VLS levels.Targeted interventions,including enhanced HIV disclosure and peer support,are crucial for improving sustained VLS and increasing infant HIV testing uptake to reduce MTCT.展开更多
As a public policy,the Human Rights Action Plan of China provides a clear roadmap for achieving the phased goals of human rights education development.The evolution of human rights education policies over the four edi...As a public policy,the Human Rights Action Plan of China provides a clear roadmap for achieving the phased goals of human rights education development.The evolution of human rights education policies over the four editions demonstrates a clear and distinct logic of progression:human rights education in primary and secondary schools has shifted from fostering students’awareness of human rights to establishing human rights values;human rights education in higher education has transitioned from the construction of single human rights course to the systematic development of human rights disciplines;human rights knowledge training has evolved from disseminating basic human rights knowledge among legal and political workers to cultivating a human rights mindset among public officials;and the popularization of human rights knowledge has moved from enhancing communication effectiveness to strengthening cultural confidence in human rights.These shifts reflect the characteristics of the policy evolution of human rights education,which are unified in their gradual and continuous nature,responsiveness and forward-looking nature,and value-oriented and contemporary nature.Fundamentally,the gap between the current state of human rights education development and policy goals serves as the intrinsic driving force for the evolution of human rights education policies.While the external factors influencing the evolution of policy content mainly include the human rights cause’s contemporary context,historical achievements,and current needs.Looking ahead to the future development of human rights education,it is essential to continuously innovate human rights teaching methods,enrich the content of human rights education,improve relevant institutional guarantee mechanisms,strengthen the construction of multi-stakeholder collaborative human rights education teams,compile and publish high-quality human rights textbooks,and increase the intensity of human rights knowledge training for journalists,in order to create a favorable public opinion atmosphere and cultural environment for the development of China’s human rights cause in the new era.展开更多
The development of human settlements(HS)in coastal cities is an integral component and a vital pathway toward building a strong marine power.It is also an essential requirement for achieving the coordinated developmen...The development of human settlements(HS)in coastal cities is an integral component and a vital pathway toward building a strong marine power.It is also an essential requirement for achieving the coordinated development of HS systems in these cities.In this study,we constructed an indicator system to analyze the coupling coordination degree(CCD)of HS systems in coastal cities in the Bohai Rim region of China(CCBRR).This study is based on five systems and employs methods such as the entropy weight method,CCD model,spatial trend surface analysis,and geographic detector to examine comprehensively the spatial and temporal patterns of CCD in 17 CCBRR during the period 2011–2022,as well as to explore their influencing factors.The findings are as follows:(1)Temporally,the CCD is high and exhibits a slow increasing trend,with distinct stage characteristics.(2)Spatially,the distribution of CCD reveals a“one core,many strengths”structural pattern.(3)Moreover,socioeconomic factors are the dominant force driving the CCD of the internal HS systems in the CCBRR.(4)Finally,we constructed a coupling coordination driving mechanism for HS in the CCBRR with the aim of providing scientific references and path choices for the high-quality and coordinated development of the CCBRR along with the implementation of the new quality productive forces regionalization.展开更多
In 2024,China’s human rights research has assumed a distinct“autonomy-oriented shift,”with scholars beginning to refine and construct uniquely Chinese and locally identifiable human rights concepts,categories,and d...In 2024,China’s human rights research has assumed a distinct“autonomy-oriented shift,”with scholars beginning to refine and construct uniquely Chinese and locally identifiable human rights concepts,categories,and discourses.Building an independent human rights knowledge system has become a core academic focus in China’s human rights research field.Upholding fundamental principles and breaking new ground are the key methodological principles for the process.China’s human rights research should be rooted in the“cultural lineage”by preserving the essence of fine traditional Chinese culture,guided by the“moral lineage”by adhering to the Marxist view on human rights,and anchored in the“Four-sphere Confidence”by upholding a distinct human rights development path,so as to define the historical coordinates and value stance of China’s independent human rights knowledge system.Meanwhile,it should maintain a high degree of openness in knowledge,theory,and methodology to address emerging rights demands and contribute to building a new global human rights governance order,so as to underscore the mission of China’s independent human rights knowledge system in the contemporary era and China’s responsibility as a major global actor.China’s human rights research should uphold the dialectical unity between the fundamental principles and innovations,and advance the systemic and theoretical interpretation of its independent human rights knowledge.展开更多
Human activities have significantly impacted the land surface temperature(LST),endangering human health;however,the relationship between these two factors has not been adequately quantified.This study comprehensively ...Human activities have significantly impacted the land surface temperature(LST),endangering human health;however,the relationship between these two factors has not been adequately quantified.This study comprehensively constructs a Human Activity Intensity(HAI)index and employs the Maximal Information Coefficient,four-quadrant model,and XGBoostSHAP model to investigate the spatiotemporal relationship and influencing factors of HAI-LST in the Yellow River Basin(YRB)from 2000 to 2020.The results indicated that from 2000 to 2020,as HAI and LST increased,the static HAI-LST relationship in the YRB showed a positive correlation that continued to strengthen.This dynamic relationship exhibited conflicting development,with the proportion of coordinated to conflicting regions shifting from 1:4 to 1:2,indicating a reduction in conflict intensity.Notably,only the degree of conflict in the source area decreased significantly,whereas it intensified in the upper and lower reaches.The key factors influencing the HAI-LST relationship include fractional vegetation cover,slope,precipitation,and evapotranspiration,along with region-specific factors such as PM_(2.5),biodiversity,and elevation.Based on these findings,region-specific ecological management strategies have been proposed to mitigate conflict-prone areas and alleviate thermal stress,thereby providing important guidance for promoting harmonious development between humans and nature.展开更多
The Chinese perspective is an open and evolving theoretical system.From a spatiotemporal viewpoint,it can be theoretically distilled into such four dimensions as the world dimension,the historical dimension,the practi...The Chinese perspective is an open and evolving theoretical system.From a spatiotemporal viewpoint,it can be theoretically distilled into such four dimensions as the world dimension,the historical dimension,the practical dimension,and the theoretical dimension,which collectively form a“unified framework of four”of logical construction.The“world”dimension represents the synchronic extension of human rights practices,outwardly touching on the shared values of all humanity guided by relational rationality and the vision of a community with a shared future for humanity.The“historical”dimension reflects the diachronic extension of China’s path of human rights development,encompassing the cultural subjectivity of Chinese civilization and the complex context of modern human rights endeavors.The“practical”dimension serves as the“meta-perspective”of contemporary Chinese perspective on human rights,where the leadership of the Communist Party of China and the people-centered approach constitute the fundamental stance for developing the perspectives of human rights and human rights governance.The“theoretical”dimension focuses on the deconstruction and reconstruction of indigenous human rights notions,emphasizing a set of values that are confident,inclusive,equitable,shared,and forward-looking.The“world”dimension of“taking the world as a method”,provides a reference perspective for“taking China as a method”narrative centered on the“historical-practical-theoretical”framework,while the latter injects a human rights methodology grounded in Chinese wisdom into the former.By integrating these four dimensions,a more profound and comprehensive understanding of the value core and normative paradigm of contemporary Chinese perspective on human rights can be achieved.展开更多
Human dignity is widely regarded as the foundation of modern human rights concepts and norms.The doctrine of human dignity in Chinese culture enjoys a long and profound history,and the pre-Qin assertion that“humans a...Human dignity is widely regarded as the foundation of modern human rights concepts and norms.The doctrine of human dignity in Chinese culture enjoys a long and profound history,and the pre-Qin assertion that“humans are the most precious”is the most representative expression of human dignity.Ancient Chinese scholars’elaboration on dignity was ethically oriented;they affirmed that humans have the freedom to make moral choices in spirit and required them to assume moral responsibilities towards others and society.Since modern times,with the changes of the times and the introduction of Western liberalism,the traditional view of moral dignity has seen a significant expansion of its scope,incorporating freedom in economic,political,and social life into the category of human dignity and establishing a closer connection with human rights.In contemporary China,under the guidance of Marxism,the view of dignity regards the free,comprehensive,and common development of human beings as the intrinsic requirement and external manifestation of human dignity,takes the rights to subsistence and development as the primary and fundamental human rights,and comprehensively safeguards the dignity of every individual through the coordinated protection of economic,political,social,and cultural rights.展开更多
At the 2024 China-Europe Seminar on Human Rights,over 60 experts and scholars from 16 countries gathered to discuss“Safeguarding Emerging Rights:Perspectives from China and Europe.”The seminar highlighted that the g...At the 2024 China-Europe Seminar on Human Rights,over 60 experts and scholars from 16 countries gathered to discuss“Safeguarding Emerging Rights:Perspectives from China and Europe.”The seminar highlighted that the global new round of technological revolution and industrial transformation,along with changes in production methods and social structures,as well as the rising awareness of human rights,have led to the emergence of many new rights.At the same time,these developments have also given traditional human rights new digital forms.The constant emergence of new rights concepts poses challenges to the traditional human rights theoretical framework and has sparked numerous debates within the international community regarding human rights theory and practice.On issues like economic equality and social rights,particularly emerging rights topics such as climate and human rights and digital human rights,countries should focus on balancing the relationship between individuals,society,and nature and seek a path for the sustainable existence and development of humanity.The core principle for protecting emerging rights should be“humanity first,”and true multilateralism should be embraced to prevent imbalances in the global governance of emerging rights.Open and fair cooperation should help build consensus and provide solutions for the global protection of emerging rights.展开更多
Hans Zempel1,2 TAU,a microtubule-associated protein,encoded by the microtubule-associated protein tau(MAPT)gene,is a central regulator of microtubule stability and axonal function in the human brain,with its pathologi...Hans Zempel1,2 TAU,a microtubule-associated protein,encoded by the microtubule-associated protein tau(MAPT)gene,is a central regulator of microtubule stability and axonal function in the human brain,with its pathological aggregation representing a hallmark of Alzheimer’s disease and related tauopathies.Despite extensive research into the role of TAU in neurodegeneration,its essentiality for human brain development has remained unclear.This perspective synthesizes recent genetic,molecular,and cellular evidence to demonstrate that the human brain-specific TAU isoform 0N3R is indispensable for proper neurodevelopment,pointing to loss-of-function of this isoform as a novel paradigm for TAU-associated disease.Alternative splicing of MAPT generates six brain-specific TAU isoforms,with 0N3R being exclusively expressed during fetal brain development.Analysis of large-scale human genetic datasets(gnomAD v4.0.0)reveals a high probability of loss-of-function intolerance(pLI=0.96)for the 0N3R isoform.This is in stark contrast to the canonical Matched Annotation from the NCBI and EMBL-EBI(MANE)transcript and peripheral“Big TAU,”both of which are tolerant to loss-of-function mutations.This intolerance is further supported by the scarcity of loss-of-function mutations in 0N3R-encoding exons and high missense constraint scores,suggesting strong evolutionary selection against disruption of this isoform.Functional studies using human induced pluripotent stem cell-derived cortical neurons with CRISPR-Cas9-mediated MAPT knockout reveal that,unlike in murine models where compensation by other microtubule-associated proteins occurs,loss of TAU in human neurons leads to deficits in neurite outgrowth,axon initial segment shortening,and a trend toward hyperexcitability,accompanied by broad transcriptomic changes affecting genes involved in microtubule organization and synaptic structure.Remarkably,re-expression of any of the six human brain-specific TAU isoforms rescues these phenotypes,underscoring their functional redundancy during development.These findings position the 0N3R isoform as essential for human brain development and suggest that loss-of-function mutations affecting this isoform likely result in neurodevelopmental impairment,potentially manifesting as intellectual disability without overt dysmorphic features.This contrasts with the apparent tolerance to MAPT loss-of-function in mice and peripheral tissues,highlighting a critical species-and isoform-specific requirement for TAU in human neurodevelopment.The hypothesis of 0N3R-TAU loss-of-function intolerance opens new avenues for understanding neurodevelopmental disorders and refines the conceptual framework of TAU-associated disease mechanisms beyond toxic gain-of-function.展开更多
DIS3 is the main catalytic subunit of the nuclear RNA exosome,a complex playing a crucial role in RNA processing and the degradation of various noncoding RNA substrates.In mice,DIS3 is essential for genomic rearrangem...DIS3 is the main catalytic subunit of the nuclear RNA exosome,a complex playing a crucial role in RNA processing and the degradation of various noncoding RNA substrates.In mice,DIS3 is essential for genomic rearrangements during B cell development,but its role in terminal plasma cell(PC)differentiation has not been explored.Although DIS3 gene alterations are frequent in multiple myeloma(MM),a PC malignancy,their molecular impact remains poorly understood.In this study,we developed an antisense oligonucleotide strategy to knock down DIS3 expression in a well-characterized model of human PC differentiation.Reducing DIS3 expression systematically led to decreased B cell proliferation and impaired PC differentiation with lower levels of switched immunoglobulin secretion.Transcriptome analyses confirmed alterations in the proliferation and differentiation programs,alongside an accumulation of noncoding RNAs.Notably,centromere-associated noncoding RNAs were highly sensitive to DIS3 activity,and their accumulation in DIS3-deficient cells,either as transcripts or DNA-associated RNAs,correlated with the mislocalization of the centromere-specific histone variant CENP-A.We finally observed reduced physiological DNA recombination and somatic hypermutation but increased genomic instability in DIS3-deficient cells,in agreement with the higher levels of IGH translocations observed in our large cohort of DIS3-mutant MM patients.Together,these results underscore the essential role of DIS3 in regulating B cell proliferation,DNA recombination,and physiological or malignant PC differentiation in humans.展开更多
The year 2025 marked the 80^(th) anniversary of the founding of the United Nations(UN).Over the past eight decades,the UN has played an irreplaceable and important role in safeguarding peace and security,advancing eco...The year 2025 marked the 80^(th) anniversary of the founding of the United Nations(UN).Over the past eight decades,the UN has played an irreplaceable and important role in safeguarding peace and security,advancing economic and social development,and protecting human rights.展开更多
During the“Axial Age,”Chinese civilization experienced a distinctive human rights awareness characterized by its endogeneity,autonomy,and originality.This awareness,based primarily on humanism,populism,and naturalis...During the“Axial Age,”Chinese civilization experienced a distinctive human rights awareness characterized by its endogeneity,autonomy,and originality.This awareness,based primarily on humanism,populism,and naturalism,emphasized respect for human beings,highlighting the importance of caring for,respecting,and protecting people,and focusing on“benefiting the people,”“nurturing the people,”“enriching the people,”and“prospering the people.”It reflected an awareness of human rights such as the rights to life,personality,subsistence,development,and environment.This human rights awareness,oriented towards values such as“achieving benevolence,”“valuing goodness,”“revering righteousness,”“cherishing harmony,”and“seeking the public good,”established a cognitive logic that unifies human nature,virtue,and rationality.It featured a human rights spirit that is not dominated by divine authority,based on moral and ethical philosophy,and oriented towards“positive”rights.This awareness delved into the value of being human and the meaning of human existence,demonstrating creativity and innovation,and marking a significant breakthrough in the history of human rights civilization.The ideological wisdom,spiritual strength,and practical pathways contained in this human rights awareness not only laid the foundation for the human rights thought of classical Chinese civilization but are also indispensable for contemporary China’s commitment to the“two combinations”.It holds important practical significance for advancing Chinese modernization and creating a modern human rights civilization for the Chinese nation.展开更多
As a core component of Xi Jinping Thought on the Rule of Law and Xi Jinping Thought on Diplomacy,the concept of a Community with a Shared Future for Mankind plays three pivotal roles in advancing human rights:cognitiv...As a core component of Xi Jinping Thought on the Rule of Law and Xi Jinping Thought on Diplomacy,the concept of a Community with a Shared Future for Mankind plays three pivotal roles in advancing human rights:cognitive guidance,value-based evaluation,and actionable framework.It offers a normative compass for resolving human rights disputes by establishing four key value benchmarks—prioritizing common interests over parochial concerns,upholding peace and cooperation,honoring commitments,and adhering to the principle of proportionality—thereby enabling a more coherent ranking of diverse human rights perspectives.Serving as the overarching value lens for observing and analyzing human rights issues,this vision provides a robust reference framework for constructive human rights discourse.In practice,it outlines a clear actionable framework for human rights implementation,urging countries to act in the interest of individual development and collective human progress,mitigate inter-state antagonism and fragmentation,and advance human rights across five critical dimensions:peace,security,development,inclusiveness,and environmental protection.Rooted in the wisdom of traditional Chinese culture and drawing on China’s experience in global governance,the concept of a Community with a Shared Future for Mankind constitutes a guiding ideological system with profound implications for the global human rights cause.展开更多
Xi Jinping,general secretary of the Communist Party of China(CPC)Central Committee,delivered an important speech at the Commemoration of the 80th Anniversary of the Victory of the Chinese People’s War of Resistance A...Xi Jinping,general secretary of the Communist Party of China(CPC)Central Committee,delivered an important speech at the Commemoration of the 80th Anniversary of the Victory of the Chinese People’s War of Resistance Against Japanese Aggression(1931-1945)and the World Anti-Fascist War.展开更多
The basic human rights concepts in Chinese classics mainly encompass three categories:the concept of order and freedom influenced by the worldview of the harmony between humanity and nature,the concept of human subjec...The basic human rights concepts in Chinese classics mainly encompass three categories:the concept of order and freedom influenced by the worldview of the harmony between humanity and nature,the concept of human subjectivity and the source of human rights influenced by the people-oriented or benevolence-oriented values,as well as the concept of the relationship between human rights and state power guided by the outlook on life of the great unity of all under heaven(tianxia).Among them,the concept of order and freedom of the harmony between humanity and nature and modeling itself on nature is more beneficial to the stability and development of human society than the Western concept of order and freedom under“rational choice.”The norm prototype of“Do not do to others what you do not want others to do to you”formed the Article 4 of the French Declaration of the Rights of Man and of the Citizen in 1789,and the concepts of“benevolence”and“human superiority”were written into Article 1 of the Universal Declaration of Human Rights and the preamble of the Declaration of the United Nations Conference on the Human Environment,respectively,which have become the common spiritual wealth of all humankind.The ancient Chinese imperial examination system for selecting virtuous and capable people was basically consistent with the provisions on the political rights of citizens to hold public office stipulated in contemporary human rights documents,and was advanced in the world at that time.The contemporary Chinese system of“the state respects and protects human rights”is a system rooted in the Chinese historical and cultural traditions and is with the superiority of socialism.展开更多
The 2030 Agenda for Sustainable Development provides a core framework and platform for global development,mainly characterized by the incorporation of human rights protection responsibilities and explicit acknowledgme...The 2030 Agenda for Sustainable Development provides a core framework and platform for global development,mainly characterized by the incorporation of human rights protection responsibilities and explicit acknowledgment of the shared role of development and human rights in safeguarding human dignity and well-being.Human rights responsibilities require states to prioritize human development within their development agenda,achieve human rights through development,and adhere to human rights principles and standards.Integrating human rights responsibilities into the development agenda not only makes development more comprehensive but also provides legal constraints and monitoring mechanisms for the implementation of development goals.The 2030 Agenda for Sustainable Development redefines the relationship between development and human rights and is thus closely aligned with China’s practice of advancing sustainable development and human rights protection simultaneously.Guided by the people-centered development philosophy and new development philosophy,China has accomplished the historic tasks of the fight against poverty and the building of a moderately prosperous society in all respects,while significantly enhancing human rights protection.These achievements have provided a unique country-specific experience of“promoting human rights through development”for the implementation of sustainable development goals.展开更多
The current international dissemination of China’s human rights discourse predominantly adopts a“sender-oriented”model,emphasizing the output of human rights discourse by transmitters while overlooking strategy adj...The current international dissemination of China’s human rights discourse predominantly adopts a“sender-oriented”model,emphasizing the output of human rights discourse by transmitters while overlooking strategy adjustments based on audience feedback.To some extent,the current approach has resulted in characteristics such as strong practical implementation but weak discourse,limited theoretical foundation,and insufficient recognition in China’s international human rights communication.Consequently,while China has achieved remarkable progress in its human rights endeavors,human rights issues remain a critical area of stigmatization by some Western countries.An“effect-oriented”mechanism for the international dissemination of China’s human rights discourse,therefore,aims to address this challenge by re-centering the audience as active participants in the communication process.By emphasizing the dual nature of human rights’international communication,this approach leverages the reflexive monitoring of initial transmitters throughout the dissemination process to finally construct a dynamic human rights discourse framework responsive to different time and space contexts.This mechanism directly confronts the diverse backgrounds of global audiences and the resulting varied interpretations of China’s human rights discourse.It advocates for dynamic evaluation of global dissemination outcomes based on audience feedback and the timely adaptation of communication strategies according to context.By doing so,it seeks to effectively advance China’s human rights communication efforts and enhance dissemination efficiency on the global scale.展开更多
Stem cells play a crucial role in maintaining tissue regenerative capacity and homeostasis.However,mechanisms associated with stem cell senescence require further investigation.In this study,we conducted a proteomic a...Stem cells play a crucial role in maintaining tissue regenerative capacity and homeostasis.However,mechanisms associated with stem cell senescence require further investigation.In this study,we conducted a proteomic analysis of human dental pulp stem cells(HDPSCs)obtained from individuals of various ages.Our findings showed that the expression of NUP62 was decreased in aged HDPSCs.We discovered that NUP62 alleviated senescence-associated phenotypes and enhanced differentiation potential both in vitro and in vivo.Conversely,the knocking down of NUP62 expression aggravated the senescence-associated phenotypes and impaired the proliferation and migration capacity of HDPSCs.Through RNA-sequence and decoding the epigenomic landscapes remodeled induced by NUP62 overexpression,we found that NUP62 helps alleviate senescence in HDPSCs by enhancing the nuclear transport of the transcription factor E2F1.This,in turn,stimulates the transcription of the epigenetic enzyme NSD2.Finally,the overexpression of NUP62 influences the H3K36me2 and H3K36me3 modifications of anti-aging genes(HMGA1,HMGA2,and SIRT6).Our results demonstrated that NUP62 regulates the fate of HDPSCs via NSD2-dependent epigenetic reprogramming.展开更多
Interpreting the Universal Declaration of Human Rights from political,juridical and philosophical perspectives is es-sential for promoting the guiding principles of the Declaration,build-ing consensus on human rights,...Interpreting the Universal Declaration of Human Rights from political,juridical and philosophical perspectives is es-sential for promoting the guiding principles of the Declaration,build-ing consensus on human rights,and advancing human rights practice in the new historical context.To conduct an academic,systematic in-terpretation of the Declaration that conforms to the trends of the times and answers the fundamental questions of the world,it is necessary to find a new research paradigm.The common values of humanity,namely peace,development,equity,justice,democracy and freedom,put forward by Xi Jinping,general secretary of the Communist Party of China(CPC)Central Committee,provide the most explanatory and penetrating scientific paradigm for reaching the issue.This paper an-alyzes and reflects on the views,value foundation and principled(con-tractual)consensus of human rights in the Declaration,and narrates and foresees the far-reaching significance of the three global initia-tives(namely,the Global Development Initiative,the Global Security Initiative,and the Global Civilization Initiative)with the common val-ues of humanity as the soul in advancing the modernization of global human rights governance and building a new form of human rights civilization.展开更多
基金supported by the Belle Carnell Regenerative Neurorehabilitation Fundthe National Institutes of Health(R01NS113935 to CKF)。
文摘Human spinal cord organoids(hSCOs)offer a promising platform to study neurotrauma by addressing many limitations of traditional research models.These organoids provide access to human-specific physiological and genetic mechanisms and can be derived from an individual's somatic cells(e.g.,blood or skin).This enables patient-specific paradigms for precision neurotrauma research,pa rticula rly relevant to the over 300,000 people in the United States living with chronic effects of spinal cord injury(SCI).
文摘BACKGROUND To prevent mother to child transmission(MTCT)of human immunodeficiency virus(HIV),sustained maternal viral load suppression(VLS)and early HIV testing among HIV exposed infants(HEI)is critical.AIM To investigate maternal viral load results and infant HIV testing uptake at 6-weeks,and 9-months and 18-months in Rwanda.METHODS Between 2015 and 2022,VLS(<200 copies/mL)was measured among pregnant women living with HIV(WLHIV)from 38-healthcare facilities.Viral loads(VL)were measured at 6-months,12-months and 24-months,respectively.For maternal VL,the unit of analysis was visit-pair,and the pairs were created to define those with VL<200 copies/mL at two consecutive visits as having sustained VLS,persistent viremia(VL≥200 copies/mL at two consecutive visits),viral rebound(VL<200 copies/mL at prior visit only)and newly suppressed(VL<200 copies/mL at subsequent visit only).HEI were considered to have persistent HIV testing if they had all three HIV tests.Poisson regression models with generalized estimating equations were used to estimate the adjusted incidence rate ratio(aIRR)and 95%CI for factors associated with sustained VLS and persistent HIV testing.RESULTS A total of 1145 mother-infant pairs were analyzed.Infant HIV testing uptake at 6-weeks,9-months and 18-months was 1145(100.0%),1089(95.1%),1006(87.9%)respectively.Nine hundred ninety-nine HEI(87.3%)tested for HIV persistently.At 18-months,the incidence of HIV among HEI was 8(0.7%).Of 1145 mothers,1076(94.0%)had≥2 VL results making a total of 2010 visit-pairs(142-single;934-double visit-pairs).The incidence rate of sustained VLS,persistent viremia,viral rebound and new suppression were 91.0%,1.3%,3.6%and 4.0%respectively.Maternal disclosure of HIV status(aIRR=1.08,95%CI:1.02-1.14)was associated with increased likelihood of sustained VLS.Having peer support(aIRR=1.0595%CI:1.01-1.10)was associated with persistent HIV testing among HEI.CONCLUSION Sustained VLS is high among pregnant WLHIV in Rwanda.The low incidence of HIV among HEI may be attributed to high VLS levels.Targeted interventions,including enhanced HIV disclosure and peer support,are crucial for improving sustained VLS and increasing infant HIV testing uptake to reduce MTCT.
基金the National Social Science Fund Major Project“Research on the Background of the Formation,Logical Structure,and Value Orientation of the Chinese Human Rights Knowledge System”(Project Approval Number 24&ZD129)the National Social Science Fund Major Project“Research on General Secretary Xi Jinping’s Important Discourses on Respecting and Protecting Human Rights”(Project Approval Number 22&ZD004).
文摘As a public policy,the Human Rights Action Plan of China provides a clear roadmap for achieving the phased goals of human rights education development.The evolution of human rights education policies over the four editions demonstrates a clear and distinct logic of progression:human rights education in primary and secondary schools has shifted from fostering students’awareness of human rights to establishing human rights values;human rights education in higher education has transitioned from the construction of single human rights course to the systematic development of human rights disciplines;human rights knowledge training has evolved from disseminating basic human rights knowledge among legal and political workers to cultivating a human rights mindset among public officials;and the popularization of human rights knowledge has moved from enhancing communication effectiveness to strengthening cultural confidence in human rights.These shifts reflect the characteristics of the policy evolution of human rights education,which are unified in their gradual and continuous nature,responsiveness and forward-looking nature,and value-oriented and contemporary nature.Fundamentally,the gap between the current state of human rights education development and policy goals serves as the intrinsic driving force for the evolution of human rights education policies.While the external factors influencing the evolution of policy content mainly include the human rights cause’s contemporary context,historical achievements,and current needs.Looking ahead to the future development of human rights education,it is essential to continuously innovate human rights teaching methods,enrich the content of human rights education,improve relevant institutional guarantee mechanisms,strengthen the construction of multi-stakeholder collaborative human rights education teams,compile and publish high-quality human rights textbooks,and increase the intensity of human rights knowledge training for journalists,in order to create a favorable public opinion atmosphere and cultural environment for the development of China’s human rights cause in the new era.
基金National Natural Science Foundation of China,No.42201221,No.42471246Liaoning Province Natural Science Foundation Project,No.2023-MS-254+1 种基金Liaoning Province Social Science Planning Fund Project,No.L22CJY016Dalian Federation of Social Sciences,No.2022dlskzd037。
文摘The development of human settlements(HS)in coastal cities is an integral component and a vital pathway toward building a strong marine power.It is also an essential requirement for achieving the coordinated development of HS systems in these cities.In this study,we constructed an indicator system to analyze the coupling coordination degree(CCD)of HS systems in coastal cities in the Bohai Rim region of China(CCBRR).This study is based on five systems and employs methods such as the entropy weight method,CCD model,spatial trend surface analysis,and geographic detector to examine comprehensively the spatial and temporal patterns of CCD in 17 CCBRR during the period 2011–2022,as well as to explore their influencing factors.The findings are as follows:(1)Temporally,the CCD is high and exhibits a slow increasing trend,with distinct stage characteristics.(2)Spatially,the distribution of CCD reveals a“one core,many strengths”structural pattern.(3)Moreover,socioeconomic factors are the dominant force driving the CCD of the internal HS systems in the CCBRR.(4)Finally,we constructed a coupling coordination driving mechanism for HS in the CCBRR with the aim of providing scientific references and path choices for the high-quality and coordinated development of the CCBRR along with the implementation of the new quality productive forces regionalization.
基金a phased result funded by the Special Funds for Basic Scientific Research Expenses of Universities under the Central Government(24CXTD01).
文摘In 2024,China’s human rights research has assumed a distinct“autonomy-oriented shift,”with scholars beginning to refine and construct uniquely Chinese and locally identifiable human rights concepts,categories,and discourses.Building an independent human rights knowledge system has become a core academic focus in China’s human rights research field.Upholding fundamental principles and breaking new ground are the key methodological principles for the process.China’s human rights research should be rooted in the“cultural lineage”by preserving the essence of fine traditional Chinese culture,guided by the“moral lineage”by adhering to the Marxist view on human rights,and anchored in the“Four-sphere Confidence”by upholding a distinct human rights development path,so as to define the historical coordinates and value stance of China’s independent human rights knowledge system.Meanwhile,it should maintain a high degree of openness in knowledge,theory,and methodology to address emerging rights demands and contribute to building a new global human rights governance order,so as to underscore the mission of China’s independent human rights knowledge system in the contemporary era and China’s responsibility as a major global actor.China’s human rights research should uphold the dialectical unity between the fundamental principles and innovations,and advance the systemic and theoretical interpretation of its independent human rights knowledge.
基金Shanxi Province Graduate Research Practice Innovation Project,No.2023KY465Project on the Reform of Graduate Education and Teaching in Shanxi Province,No.2021YJJG146+1 种基金Research Project of Shanxi Provincial Cultural Relics Bureau,No.22-8-14-1400-119National Key R&D Program of China,No.2021YFB3901300。
文摘Human activities have significantly impacted the land surface temperature(LST),endangering human health;however,the relationship between these two factors has not been adequately quantified.This study comprehensively constructs a Human Activity Intensity(HAI)index and employs the Maximal Information Coefficient,four-quadrant model,and XGBoostSHAP model to investigate the spatiotemporal relationship and influencing factors of HAI-LST in the Yellow River Basin(YRB)from 2000 to 2020.The results indicated that from 2000 to 2020,as HAI and LST increased,the static HAI-LST relationship in the YRB showed a positive correlation that continued to strengthen.This dynamic relationship exhibited conflicting development,with the proportion of coordinated to conflicting regions shifting from 1:4 to 1:2,indicating a reduction in conflict intensity.Notably,only the degree of conflict in the source area decreased significantly,whereas it intensified in the upper and lower reaches.The key factors influencing the HAI-LST relationship include fractional vegetation cover,slope,precipitation,and evapotranspiration,along with region-specific factors such as PM_(2.5),biodiversity,and elevation.Based on these findings,region-specific ecological management strategies have been proposed to mitigate conflict-prone areas and alleviate thermal stress,thereby providing important guidance for promoting harmonious development between humans and nature.
基金This paper is a phased achievement of the Major Project of the Key Research Base for Humanities and Social Sciences of the Ministry of Education in 2024,titled“Theoretical Legal Studies in the Field of Human Rights”(Project Approval Number 24JJD820002).
文摘The Chinese perspective is an open and evolving theoretical system.From a spatiotemporal viewpoint,it can be theoretically distilled into such four dimensions as the world dimension,the historical dimension,the practical dimension,and the theoretical dimension,which collectively form a“unified framework of four”of logical construction.The“world”dimension represents the synchronic extension of human rights practices,outwardly touching on the shared values of all humanity guided by relational rationality and the vision of a community with a shared future for humanity.The“historical”dimension reflects the diachronic extension of China’s path of human rights development,encompassing the cultural subjectivity of Chinese civilization and the complex context of modern human rights endeavors.The“practical”dimension serves as the“meta-perspective”of contemporary Chinese perspective on human rights,where the leadership of the Communist Party of China and the people-centered approach constitute the fundamental stance for developing the perspectives of human rights and human rights governance.The“theoretical”dimension focuses on the deconstruction and reconstruction of indigenous human rights notions,emphasizing a set of values that are confident,inclusive,equitable,shared,and forward-looking.The“world”dimension of“taking the world as a method”,provides a reference perspective for“taking China as a method”narrative centered on the“historical-practical-theoretical”framework,while the latter injects a human rights methodology grounded in Chinese wisdom into the former.By integrating these four dimensions,a more profound and comprehensive understanding of the value core and normative paradigm of contemporary Chinese perspective on human rights can be achieved.
基金“Research on the Content and Realization Methods of Citizens’Participation Rights,”a major project(Project Number 21JJD820003)funded by the National Human Rights Education and Training Base of the Ministry of Education of China.
文摘Human dignity is widely regarded as the foundation of modern human rights concepts and norms.The doctrine of human dignity in Chinese culture enjoys a long and profound history,and the pre-Qin assertion that“humans are the most precious”is the most representative expression of human dignity.Ancient Chinese scholars’elaboration on dignity was ethically oriented;they affirmed that humans have the freedom to make moral choices in spirit and required them to assume moral responsibilities towards others and society.Since modern times,with the changes of the times and the introduction of Western liberalism,the traditional view of moral dignity has seen a significant expansion of its scope,incorporating freedom in economic,political,and social life into the category of human dignity and establishing a closer connection with human rights.In contemporary China,under the guidance of Marxism,the view of dignity regards the free,comprehensive,and common development of human beings as the intrinsic requirement and external manifestation of human dignity,takes the rights to subsistence and development as the primary and fundamental human rights,and comprehensively safeguards the dignity of every individual through the coordinated protection of economic,political,social,and cultural rights.
基金This paper is a phased achievement of the Major Philosophy and Social Sciences Project of the Ministry of Education,titled“Research on General Secretary Xi Jinping’s Important Discourse on Respecting and Protecting Human Rights”(Project Number 22JZD002).
文摘At the 2024 China-Europe Seminar on Human Rights,over 60 experts and scholars from 16 countries gathered to discuss“Safeguarding Emerging Rights:Perspectives from China and Europe.”The seminar highlighted that the global new round of technological revolution and industrial transformation,along with changes in production methods and social structures,as well as the rising awareness of human rights,have led to the emergence of many new rights.At the same time,these developments have also given traditional human rights new digital forms.The constant emergence of new rights concepts poses challenges to the traditional human rights theoretical framework and has sparked numerous debates within the international community regarding human rights theory and practice.On issues like economic equality and social rights,particularly emerging rights topics such as climate and human rights and digital human rights,countries should focus on balancing the relationship between individuals,society,and nature and seek a path for the sustainable existence and development of humanity.The core principle for protecting emerging rights should be“humanity first,”and true multilateralism should be embraced to prevent imbalances in the global governance of emerging rights.Open and fair cooperation should help build consensus and provide solutions for the global protection of emerging rights.
文摘Hans Zempel1,2 TAU,a microtubule-associated protein,encoded by the microtubule-associated protein tau(MAPT)gene,is a central regulator of microtubule stability and axonal function in the human brain,with its pathological aggregation representing a hallmark of Alzheimer’s disease and related tauopathies.Despite extensive research into the role of TAU in neurodegeneration,its essentiality for human brain development has remained unclear.This perspective synthesizes recent genetic,molecular,and cellular evidence to demonstrate that the human brain-specific TAU isoform 0N3R is indispensable for proper neurodevelopment,pointing to loss-of-function of this isoform as a novel paradigm for TAU-associated disease.Alternative splicing of MAPT generates six brain-specific TAU isoforms,with 0N3R being exclusively expressed during fetal brain development.Analysis of large-scale human genetic datasets(gnomAD v4.0.0)reveals a high probability of loss-of-function intolerance(pLI=0.96)for the 0N3R isoform.This is in stark contrast to the canonical Matched Annotation from the NCBI and EMBL-EBI(MANE)transcript and peripheral“Big TAU,”both of which are tolerant to loss-of-function mutations.This intolerance is further supported by the scarcity of loss-of-function mutations in 0N3R-encoding exons and high missense constraint scores,suggesting strong evolutionary selection against disruption of this isoform.Functional studies using human induced pluripotent stem cell-derived cortical neurons with CRISPR-Cas9-mediated MAPT knockout reveal that,unlike in murine models where compensation by other microtubule-associated proteins occurs,loss of TAU in human neurons leads to deficits in neurite outgrowth,axon initial segment shortening,and a trend toward hyperexcitability,accompanied by broad transcriptomic changes affecting genes involved in microtubule organization and synaptic structure.Remarkably,re-expression of any of the six human brain-specific TAU isoforms rescues these phenotypes,underscoring their functional redundancy during development.These findings position the 0N3R isoform as essential for human brain development and suggest that loss-of-function mutations affecting this isoform likely result in neurodevelopmental impairment,potentially manifesting as intellectual disability without overt dysmorphic features.This contrasts with the apparent tolerance to MAPT loss-of-function in mice and peripheral tissues,highlighting a critical species-and isoform-specific requirement for TAU in human neurodevelopment.The hypothesis of 0N3R-TAU loss-of-function intolerance opens new avenues for understanding neurodevelopmental disorders and refines the conceptual framework of TAU-associated disease mechanisms beyond toxic gain-of-function.
基金supported by the following grants:Agence nationale de la recherche(ANR)grant R23192NNInstitut national du cancer(INCa)grant PLBIO22-217+2 种基金Association pour la Recherche sur le Cancer(ARC)grant ARCPJA2021060003753 and PRTK 2021-025Ligue contre le cancer Grand-OuestAllocations de Recherche Doctorale région Bretagne/Inserm PhD fellowship.
文摘DIS3 is the main catalytic subunit of the nuclear RNA exosome,a complex playing a crucial role in RNA processing and the degradation of various noncoding RNA substrates.In mice,DIS3 is essential for genomic rearrangements during B cell development,but its role in terminal plasma cell(PC)differentiation has not been explored.Although DIS3 gene alterations are frequent in multiple myeloma(MM),a PC malignancy,their molecular impact remains poorly understood.In this study,we developed an antisense oligonucleotide strategy to knock down DIS3 expression in a well-characterized model of human PC differentiation.Reducing DIS3 expression systematically led to decreased B cell proliferation and impaired PC differentiation with lower levels of switched immunoglobulin secretion.Transcriptome analyses confirmed alterations in the proliferation and differentiation programs,alongside an accumulation of noncoding RNAs.Notably,centromere-associated noncoding RNAs were highly sensitive to DIS3 activity,and their accumulation in DIS3-deficient cells,either as transcripts or DNA-associated RNAs,correlated with the mislocalization of the centromere-specific histone variant CENP-A.We finally observed reduced physiological DNA recombination and somatic hypermutation but increased genomic instability in DIS3-deficient cells,in agreement with the higher levels of IGH translocations observed in our large cohort of DIS3-mutant MM patients.Together,these results underscore the essential role of DIS3 in regulating B cell proliferation,DNA recombination,and physiological or malignant PC differentiation in humans.
文摘The year 2025 marked the 80^(th) anniversary of the founding of the United Nations(UN).Over the past eight decades,the UN has played an irreplaceable and important role in safeguarding peace and security,advancing economic and social development,and protecting human rights.
基金the Major Project of the National Social Science Fund of China,entitled“Research on the Generative Context,Construction Logic,and Value Orientation of China’s Human Rights Knowledge System”(Project Approval Number 24&ZD129).
文摘During the“Axial Age,”Chinese civilization experienced a distinctive human rights awareness characterized by its endogeneity,autonomy,and originality.This awareness,based primarily on humanism,populism,and naturalism,emphasized respect for human beings,highlighting the importance of caring for,respecting,and protecting people,and focusing on“benefiting the people,”“nurturing the people,”“enriching the people,”and“prospering the people.”It reflected an awareness of human rights such as the rights to life,personality,subsistence,development,and environment.This human rights awareness,oriented towards values such as“achieving benevolence,”“valuing goodness,”“revering righteousness,”“cherishing harmony,”and“seeking the public good,”established a cognitive logic that unifies human nature,virtue,and rationality.It featured a human rights spirit that is not dominated by divine authority,based on moral and ethical philosophy,and oriented towards“positive”rights.This awareness delved into the value of being human and the meaning of human existence,demonstrating creativity and innovation,and marking a significant breakthrough in the history of human rights civilization.The ideological wisdom,spiritual strength,and practical pathways contained in this human rights awareness not only laid the foundation for the human rights thought of classical Chinese civilization but are also indispensable for contemporary China’s commitment to the“two combinations”.It holds important practical significance for advancing Chinese modernization and creating a modern human rights civilization for the Chinese nation.
文摘As a core component of Xi Jinping Thought on the Rule of Law and Xi Jinping Thought on Diplomacy,the concept of a Community with a Shared Future for Mankind plays three pivotal roles in advancing human rights:cognitive guidance,value-based evaluation,and actionable framework.It offers a normative compass for resolving human rights disputes by establishing four key value benchmarks—prioritizing common interests over parochial concerns,upholding peace and cooperation,honoring commitments,and adhering to the principle of proportionality—thereby enabling a more coherent ranking of diverse human rights perspectives.Serving as the overarching value lens for observing and analyzing human rights issues,this vision provides a robust reference framework for constructive human rights discourse.In practice,it outlines a clear actionable framework for human rights implementation,urging countries to act in the interest of individual development and collective human progress,mitigate inter-state antagonism and fragmentation,and advance human rights across five critical dimensions:peace,security,development,inclusiveness,and environmental protection.Rooted in the wisdom of traditional Chinese culture and drawing on China’s experience in global governance,the concept of a Community with a Shared Future for Mankind constitutes a guiding ideological system with profound implications for the global human rights cause.
文摘Xi Jinping,general secretary of the Communist Party of China(CPC)Central Committee,delivered an important speech at the Commemoration of the 80th Anniversary of the Victory of the Chinese People’s War of Resistance Against Japanese Aggression(1931-1945)and the World Anti-Fascist War.
文摘The basic human rights concepts in Chinese classics mainly encompass three categories:the concept of order and freedom influenced by the worldview of the harmony between humanity and nature,the concept of human subjectivity and the source of human rights influenced by the people-oriented or benevolence-oriented values,as well as the concept of the relationship between human rights and state power guided by the outlook on life of the great unity of all under heaven(tianxia).Among them,the concept of order and freedom of the harmony between humanity and nature and modeling itself on nature is more beneficial to the stability and development of human society than the Western concept of order and freedom under“rational choice.”The norm prototype of“Do not do to others what you do not want others to do to you”formed the Article 4 of the French Declaration of the Rights of Man and of the Citizen in 1789,and the concepts of“benevolence”and“human superiority”were written into Article 1 of the Universal Declaration of Human Rights and the preamble of the Declaration of the United Nations Conference on the Human Environment,respectively,which have become the common spiritual wealth of all humankind.The ancient Chinese imperial examination system for selecting virtuous and capable people was basically consistent with the provisions on the political rights of citizens to hold public office stipulated in contemporary human rights documents,and was advanced in the world at that time.The contemporary Chinese system of“the state respects and protects human rights”is a system rooted in the Chinese historical and cultural traditions and is with the superiority of socialism.
文摘The 2030 Agenda for Sustainable Development provides a core framework and platform for global development,mainly characterized by the incorporation of human rights protection responsibilities and explicit acknowledgment of the shared role of development and human rights in safeguarding human dignity and well-being.Human rights responsibilities require states to prioritize human development within their development agenda,achieve human rights through development,and adhere to human rights principles and standards.Integrating human rights responsibilities into the development agenda not only makes development more comprehensive but also provides legal constraints and monitoring mechanisms for the implementation of development goals.The 2030 Agenda for Sustainable Development redefines the relationship between development and human rights and is thus closely aligned with China’s practice of advancing sustainable development and human rights protection simultaneously.Guided by the people-centered development philosophy and new development philosophy,China has accomplished the historic tasks of the fight against poverty and the building of a moderately prosperous society in all respects,while significantly enhancing human rights protection.These achievements have provided a unique country-specific experience of“promoting human rights through development”for the implementation of sustainable development goals.
基金This paper is a phased outcome of the“Research on the Strategy to Improve the Mechanism for the International Dissemination of China’s Human Rights Discourse”(22JJD820045),a key research project of the National Human Rights Education and Training Base under China’s Ministry of Education.
文摘The current international dissemination of China’s human rights discourse predominantly adopts a“sender-oriented”model,emphasizing the output of human rights discourse by transmitters while overlooking strategy adjustments based on audience feedback.To some extent,the current approach has resulted in characteristics such as strong practical implementation but weak discourse,limited theoretical foundation,and insufficient recognition in China’s international human rights communication.Consequently,while China has achieved remarkable progress in its human rights endeavors,human rights issues remain a critical area of stigmatization by some Western countries.An“effect-oriented”mechanism for the international dissemination of China’s human rights discourse,therefore,aims to address this challenge by re-centering the audience as active participants in the communication process.By emphasizing the dual nature of human rights’international communication,this approach leverages the reflexive monitoring of initial transmitters throughout the dissemination process to finally construct a dynamic human rights discourse framework responsive to different time and space contexts.This mechanism directly confronts the diverse backgrounds of global audiences and the resulting varied interpretations of China’s human rights discourse.It advocates for dynamic evaluation of global dissemination outcomes based on audience feedback and the timely adaptation of communication strategies according to context.By doing so,it seeks to effectively advance China’s human rights communication efforts and enhance dissemination efficiency on the global scale.
基金supported by the National Natural Science Foundation of China(32171347)the Foundation of Leading Talents from Shanghai Health Commission(2022XD038)+1 种基金Training Program for Research Physicians in Innovation,the Funda-mental Research Funds for the Central Universities(YG2023QNA23)Transforma-tion from shanghai hospital development center(SHDC2022CRD002).
文摘Stem cells play a crucial role in maintaining tissue regenerative capacity and homeostasis.However,mechanisms associated with stem cell senescence require further investigation.In this study,we conducted a proteomic analysis of human dental pulp stem cells(HDPSCs)obtained from individuals of various ages.Our findings showed that the expression of NUP62 was decreased in aged HDPSCs.We discovered that NUP62 alleviated senescence-associated phenotypes and enhanced differentiation potential both in vitro and in vivo.Conversely,the knocking down of NUP62 expression aggravated the senescence-associated phenotypes and impaired the proliferation and migration capacity of HDPSCs.Through RNA-sequence and decoding the epigenomic landscapes remodeled induced by NUP62 overexpression,we found that NUP62 helps alleviate senescence in HDPSCs by enhancing the nuclear transport of the transcription factor E2F1.This,in turn,stimulates the transcription of the epigenetic enzyme NSD2.Finally,the overexpression of NUP62 influences the H3K36me2 and H3K36me3 modifications of anti-aging genes(HMGA1,HMGA2,and SIRT6).Our results demonstrated that NUP62 regulates the fate of HDPSCs via NSD2-dependent epigenetic reprogramming.
基金the major special project of the Ministry of Education for Philosophy and Social Science Research,“Research on the Basic Theory and Core Essence of Xi Jinping Thought on the Rule of Law”(Project Approv-al Number 2022JZDZ001).
文摘Interpreting the Universal Declaration of Human Rights from political,juridical and philosophical perspectives is es-sential for promoting the guiding principles of the Declaration,build-ing consensus on human rights,and advancing human rights practice in the new historical context.To conduct an academic,systematic in-terpretation of the Declaration that conforms to the trends of the times and answers the fundamental questions of the world,it is necessary to find a new research paradigm.The common values of humanity,namely peace,development,equity,justice,democracy and freedom,put forward by Xi Jinping,general secretary of the Communist Party of China(CPC)Central Committee,provide the most explanatory and penetrating scientific paradigm for reaching the issue.This paper an-alyzes and reflects on the views,value foundation and principled(con-tractual)consensus of human rights in the Declaration,and narrates and foresees the far-reaching significance of the three global initia-tives(namely,the Global Development Initiative,the Global Security Initiative,and the Global Civilization Initiative)with the common val-ues of humanity as the soul in advancing the modernization of global human rights governance and building a new form of human rights civilization.
