Objective:To analyze the diagnostic value of transvaginal three-dimensional ultrasound(3D-TVS)in evaluating endometrial receptivity(ER)for ovulation disorder infertility(ODI),and to investigate the impact of subendome...Objective:To analyze the diagnostic value of transvaginal three-dimensional ultrasound(3D-TVS)in evaluating endometrial receptivity(ER)for ovulation disorder infertility(ODI),and to investigate the impact of subendometrial endometrial vascular index(VI)and endometrial vascular flow index(VFI)levels on ODI.Methods:A total of 110 patients diagnosed with ODI admitted between January 2023 and June 2024 were selected.All patients underwent ovulation induction therapy,3D-TVS examination,and sex hormone testing.Based on pregnancy outcomes,patients were divided into a successful pregnancy group(73 cases)and an unsuccessful pregnancy group(37 cases).ER parameters,sex hormone levels,and endometrial blood flow patterns were compared between the two groups.Receiver operating characteristic(ROC)curves were plotted to evaluate the predictive value of ER for ODI.Results:The spiral artery peak systolic velocity(PSV),endometrial volume(EMV),endometrial flow index(FI),and VFI in the successful pregnancy group were significantly higher than those in the unsuccessful pregnancy group(p<0.05).No significant differences were observed in other ER parameters between the two groups(p>0.05).There was no significant difference in sex hormone levels between the two groups on the day of human chorionic gonadotropin(hCG)treatment(p>0.05).Among the endometrial blood flow classifications in the pregnant group,the proportion of Type II was lower than that in the nonpregnant group(p<0.05).The Receiver Operating Characteristic(ROC)curve demonstrated that the area under the curve(AUC)for Endometrial Volume(EMV)in predicting pregnancy after Ovarian Dysfunction Infertility(ODI)treatment was 0.854,with a sensitivity of 92.61%and a specificity of 71.75%.The AUC for Vascularization Index(VI)was 0.771,with a sensitivity of 52.18%and a specificity of 88.70%.The AUC for Vascularization Flow Index(VFI)of the endometrium was 0.887,with a sensitivity of 80.01%and a specificity of 69.20%.Conclusion:Three-dimensional transvaginal sonography(3D-TVS)assessment of endometrial receptivity(ER)can effectively detect ODI,and the levels of subendometrial VI and VFI demonstrate superior predictive performance for pregnancy outcomes in this condition,serving as commonly used predictive indicators for the disease.展开更多
To analyze the therapeutic effect of mifepristone, misoprostol and curettage on embryo development. Methods: 56 patients with embryonic development arrest diagnosed and treated in our hospital from March 2019 to March...To analyze the therapeutic effect of mifepristone, misoprostol and curettage on embryo development. Methods: 56 patients with embryonic development arrest diagnosed and treated in our hospital from March 2019 to March 2021 were selected as observation objects, and were divided into two groups according to different treatment plans. The reference group and the research group were treated with misoprostol combined with curettage, mifepristone and misoprostol combined with curettage respectively. The effects of cervical softening and dilation, success rate of one-time curettage, operation index, incidence of adverse reactions and the effects on the levels of immune function index, D- dimer and three items of thyroid function of patients in the two groups were compared. Results: compared with the reference group, the total effective rate of cervical softening and dilation in the study group was 96.43%, the success rate of one-time curettage was 100.00% higher, the time of operation, pregnancy discharge and vaginal hemorrhage were shorter, the amount of intraoperative hemorrhage was less, the levels of immune function indexes (IgA, IgM, IgG) were higher, and the values of three indexes of three items of thyroid function (TSH, FT3, FT4) and D- dimer were lower in the study group, P<0.05. There was no significant difference in the incidence of adverse reactions between the two groups (P>0.05). Conclusion: the combined use of mifepristone, misoprostol and curettage in patients with embryonic development arrest has significant effects on improving the cervical softening and dilation effect, increasing the success rate of one-time curettage and improving the operation condition of patients, immune function after treatment, D- dimer and three indexes of hypothyroidism.展开更多
文摘Objective:To analyze the diagnostic value of transvaginal three-dimensional ultrasound(3D-TVS)in evaluating endometrial receptivity(ER)for ovulation disorder infertility(ODI),and to investigate the impact of subendometrial endometrial vascular index(VI)and endometrial vascular flow index(VFI)levels on ODI.Methods:A total of 110 patients diagnosed with ODI admitted between January 2023 and June 2024 were selected.All patients underwent ovulation induction therapy,3D-TVS examination,and sex hormone testing.Based on pregnancy outcomes,patients were divided into a successful pregnancy group(73 cases)and an unsuccessful pregnancy group(37 cases).ER parameters,sex hormone levels,and endometrial blood flow patterns were compared between the two groups.Receiver operating characteristic(ROC)curves were plotted to evaluate the predictive value of ER for ODI.Results:The spiral artery peak systolic velocity(PSV),endometrial volume(EMV),endometrial flow index(FI),and VFI in the successful pregnancy group were significantly higher than those in the unsuccessful pregnancy group(p<0.05).No significant differences were observed in other ER parameters between the two groups(p>0.05).There was no significant difference in sex hormone levels between the two groups on the day of human chorionic gonadotropin(hCG)treatment(p>0.05).Among the endometrial blood flow classifications in the pregnant group,the proportion of Type II was lower than that in the nonpregnant group(p<0.05).The Receiver Operating Characteristic(ROC)curve demonstrated that the area under the curve(AUC)for Endometrial Volume(EMV)in predicting pregnancy after Ovarian Dysfunction Infertility(ODI)treatment was 0.854,with a sensitivity of 92.61%and a specificity of 71.75%.The AUC for Vascularization Index(VI)was 0.771,with a sensitivity of 52.18%and a specificity of 88.70%.The AUC for Vascularization Flow Index(VFI)of the endometrium was 0.887,with a sensitivity of 80.01%and a specificity of 69.20%.Conclusion:Three-dimensional transvaginal sonography(3D-TVS)assessment of endometrial receptivity(ER)can effectively detect ODI,and the levels of subendometrial VI and VFI demonstrate superior predictive performance for pregnancy outcomes in this condition,serving as commonly used predictive indicators for the disease.
文摘To analyze the therapeutic effect of mifepristone, misoprostol and curettage on embryo development. Methods: 56 patients with embryonic development arrest diagnosed and treated in our hospital from March 2019 to March 2021 were selected as observation objects, and were divided into two groups according to different treatment plans. The reference group and the research group were treated with misoprostol combined with curettage, mifepristone and misoprostol combined with curettage respectively. The effects of cervical softening and dilation, success rate of one-time curettage, operation index, incidence of adverse reactions and the effects on the levels of immune function index, D- dimer and three items of thyroid function of patients in the two groups were compared. Results: compared with the reference group, the total effective rate of cervical softening and dilation in the study group was 96.43%, the success rate of one-time curettage was 100.00% higher, the time of operation, pregnancy discharge and vaginal hemorrhage were shorter, the amount of intraoperative hemorrhage was less, the levels of immune function indexes (IgA, IgM, IgG) were higher, and the values of three indexes of three items of thyroid function (TSH, FT3, FT4) and D- dimer were lower in the study group, P<0.05. There was no significant difference in the incidence of adverse reactions between the two groups (P>0.05). Conclusion: the combined use of mifepristone, misoprostol and curettage in patients with embryonic development arrest has significant effects on improving the cervical softening and dilation effect, increasing the success rate of one-time curettage and improving the operation condition of patients, immune function after treatment, D- dimer and three indexes of hypothyroidism.
