This paper gives insight into the use of underground space in Helsinki,Finland.The city has an underground master plan(UMP) for its whole municipal area,not only for certain parts of the city.Further,the decision-maki...This paper gives insight into the use of underground space in Helsinki,Finland.The city has an underground master plan(UMP) for its whole municipal area,not only for certain parts of the city.Further,the decision-making history of the UMP is described step-by-step.Some examples of underground space use in other cities are also given.The focus of this paper is on the sustainability issues related to urban underground space use,including its contribution to an environmentally sustainable and aesthetically acceptable landscape,anticipated structural longevity and maintaining the opportunity for urban development by future generations.Underground planning enhances overall safety and economy efficiency.The need for underground space use in city areas has grown rapidly since the 21 st century;at the same time,the necessity to control construction work has also increased.The UMP of Helsinki reserves designated space for public and private utilities in various underground areas of bedrock over the long term.The plan also provides the framework for managing and controlling the city’s underground construction work and allows suitable locations to be allocated for underground facilities.Tampere,the third most populated city in Finland and the biggest inland city in the Nordic countries,is also a good example of a city that is taking steps to utilise underground resources.Oulu,the capital city of northern Finland,has also started to ‘go underground’.An example of the possibility to combine two cities by an 80-km subsea tunnel is also discussed.A new fixed link would generate huge potential for the capital areas of Finland and Estonia to become a real Helsinki-Tallinn twin city.展开更多
The visual system of teleost fish grows continuously,which is a useful model for studying regeneration of the central nervous system.Glial cells are key for this process,but their contribution is still not well define...The visual system of teleost fish grows continuously,which is a useful model for studying regeneration of the central nervous system.Glial cells are key for this process,but their contribution is still not well defined.We followed oligodendrocytes in the visual system of adult zebrafish during regeneration of the optic nerve at 6,24,and 72 hours post-lesion and at 7 and 14 days post-lesion via the sox10:tagRFP transgenic line and confocal microscopy.To understand the changes that these oligodendrocytes undergo during regeneration,we used Sox2 immunohistochemistry,a stem cell marker involved in oligodendrocyte differentiation.We also used the Click-iT™ Plus TUNEL assay to study cell death and a BrdU assay to determine cell proliferation.Before optic nerve crush,sox10:tagRFP oligodendrocytes are located in the retina,in the optic nerve head,and through all the entire optic nerve.Sox2-positive cells are present in the peripheral germinal zone,the mature retina,and the optic nerve.After optic nerve crush,sox10:tagRFP cells disappeared from the optic nerve crush zone,suggesting that they died,although they were not TUNEL positive.Concomitantly,the number of Sox2-positive cells increased around the crushed area,the optic nerve head,and the retina.Then,between 24 hours post-lesion and 14 days post-lesion,double sox10:tagRFP/Sox2-positive cells were detected in the retina,optic nerve head,and whole optic nerve,together with a proliferation response at 72 hours post-lesion.Our results confirm that a degenerating process may occur prior to regeneration.First,sox10:tagRFP oligodendrocytes that surround the degenerated axons stop wrapping them,change their“myelinating oligodendrocyte”morphology to a“nonmyelinating oligodendrocyte”morphology,and die.Then,residual oligodendrocyte progenitor cells in the optic nerve and retina proliferate and differentiate for the purpose of remyelination.As new axons arise from the surviving retinal ganglion cells,new sox10:tagRFP oligodendrocytes arise from residual oligodendrocyte progenitor cells to guide,nourish and myelinate them.Thus,oligodendrocytes play an active role in zebrafish axon regeneration and remyelination.展开更多
Urban tree species provide various essential ecosystem services in cities,such as regulating urban temperatures,reducing noise,capturing carbon,and mitigating the urban heat island effect.The quality of these services...Urban tree species provide various essential ecosystem services in cities,such as regulating urban temperatures,reducing noise,capturing carbon,and mitigating the urban heat island effect.The quality of these services is influenced by species diversity,tree health,and the distribution and the composition of trees.Traditionally,data on urban trees has been collected through field surveys and manual interpretation of remote sensing images.In this study,we evaluated the effectiveness of multispectral airborne laser scanning(ALS)data in classifying 24 common urban roadside tree species in Espoo,Finland.Tree crown structure information,intensity features,and spectral data were used for classification.Eight different machine learning algorithms were tested,with the extra trees(ET)algorithm performing the best,achieving an overall accuracy of 71.7%using multispectral LiDAR data.This result highlights that integrating structural and spectral information within a single framework can improve the classification accuracy.Future research will focus on identifying the most important features for species classification and developing algorithms with greater efficiency and accuracy.展开更多
Objectives:Childhood and adolescent obesity are an increasing global health concern.This study aimed to evaluate the effectiveness of digital components and interaction types in counseling interventions for prevention...Objectives:Childhood and adolescent obesity are an increasing global health concern.This study aimed to evaluate the effectiveness of digital components and interaction types in counseling interventions for prevention and treatment.Methods:All studies were searched in online databases and grey literature,including PubMed(Medline),Web of Science,CINAHL,Scopus,IEEE Xplore Digital Library,Journal of Medical Internet Research(JMIR),MedNar,EBSco Open Dissertations.The search period is from inception to June 2023,and the languages are Finnish,English and Swedish.The research quality was evaluated using the web-based data management system Covidence for prevalence studies.The study protocol was registered with PROSPERO(registration number:CRD42021247595).Results:In this review,4,407 studies were screened,and 22 were included.These involved 3,433 participants and 264 child-parent pairs.The digital approaches included multicomponent elements like internet platforms,text messaging,video conferencing,online communities,wearable technology,and mobile apps,allowing one-way,two-way,and face-to-face interactions.Two studies showed statistically significant effects of treatment on BMI and waist-to-hip ratio.Most interventions reported positive outcomes,with no significant differences between groups,and none showed null effects during followup.Conclusions:Digital multicomponents like mobile apps and wearables can help obese children and adolescents adopt healthier lifestyles.While these interventions show promise for obesity management,further research is needed to assess their effectiveness,particularly regarding nurses'perspectives.展开更多
We review a 3d quantum gravity model, which incorporates massive spinning fields into the Euclidean path integral in a Chern-Simons formulation. Fundamental matter as defined in our previous preon model is recapped. B...We review a 3d quantum gravity model, which incorporates massive spinning fields into the Euclidean path integral in a Chern-Simons formulation. Fundamental matter as defined in our previous preon model is recapped. Both quantum gravity and the particle model are shown to be derivable from the supersymmetric 3d Chern-Simons action. Forces-Matter unification is achieved.展开更多
The current Tanzanian policy guidelines regarding ecological restoration encourage total protection (enclosure system) against grazing activities, fires and wood extraction to allow regeneration in state-based Miombo ...The current Tanzanian policy guidelines regarding ecological restoration encourage total protection (enclosure system) against grazing activities, fires and wood extraction to allow regeneration in state-based Miombo woodlands. However, there is little evidence on how such treatments would promote restoration. We fetched the pieces of evidence from studies that evaluated the impact of management treatments on the lightly degraded Miombo woodlands at Kitulangalo Forest Reserve in eastern Tanzania. Plot fencing and fire exclusion constrained woody species regeneration due to competition compared to unfenced plots. Adopting quota grazing policies and controlled burning systems can be the shortest and most eco-friendly pathways towards Miombo restoration. The results pointed out that stand disturbances and silvicultural practices can promote regeneration, which is crucial to promoting ecological restoration in Miombo woodlands.展开更多
PurposeThe study aimed to investigate the otology-specific and general health-related quality of life(HRQoL)after cochlear implantation,and scrutinize the variables associated with them.MethodsThe Ear Outcome Survey-1...PurposeThe study aimed to investigate the otology-specific and general health-related quality of life(HRQoL)after cochlear implantation,and scrutinize the variables associated with them.MethodsThe Ear Outcome Survey-16(EOS-16),which assesses ear-specific symptoms and quality of life(QoL),was administered before and after cochlear implantation along with the post-operative administration of the 15D questionnaire that evaluates general HRQoL.The authors investigated post-implantation changes in the EOS-16 total scores and its category responses,examining their relationship with pre-and post-operative hearing levels,speech perception in noise,and the follow-up period length(time elapsed since cochlear implantation).ResultsThere were positive changes noted for the hearing,need for care,and QoL categories of the EOS-16 after implantation.The length of the follow-up period was a significant factor associated with improvements in subjective outcome measures.Changes in self-perceived hearing and HRQoL post-implantation seem independent of pre-and post-implantation hearing performance.ConclusionThese results suggest that while patients regain their hearing abilities shortly after implant activation,their subjective hearing-related benefits and QoL improve over time.展开更多
The duration of snow cover has shortened in the boreal region,and the amount of seasonal snow decreased.This affects the coupling between soil and air temperatures and may thus lead to colder soil and deeper soil fros...The duration of snow cover has shortened in the boreal region,and the amount of seasonal snow decreased.This affects the coupling between soil and air temperatures and may thus lead to colder soil and deeper soil frost.We prevented snow reaching the forest floor for two winters in mature boreal forest and studied how that affects tree and forest floor processes.The studied species were Scots pine,Norway spruce,silver birch,and a dwarf shrub bilberry.Decreased soil temperature,due to the lack of snow cover,decreased forest floor respiration in winter and spring.Simultaneously,response of respiration to temperature seemed to increase,perhaps due to the exposure of forest floor vegetation to cold air temperature.Indeed,lack of snow cover induced mortality of bilberry,but the remaining ramets grew more in height and their average leaf size was larger likely to compensate for the lost plant biomass.Lack of snow cover also affected tree hydraulics as tree water uptake was decreased in spring,and the start of the sap season delayed in birch.Pine and birch tended to grow less in the snow exclusion treatment(differences not statistically significant),whereas spruce grew more.Coarse root traits,e.g.water content and cellular frost damages,were not affected by the snow exclusion treatment.The results of this case study increase our understanding on the effects of changing snow cover on spring-time tree and forest floor processes in mature boreal forest,but also reveal the need for further studies on mature trees.展开更多
AIM:To examine effects of switching intravitreal aflibercept to bevacizumab in neovascular age-related macular degeneration(nAMD).METHODS:Data from patients treated for nAMD with anti-vascular endothelial growth facto...AIM:To examine effects of switching intravitreal aflibercept to bevacizumab in neovascular age-related macular degeneration(nAMD).METHODS:Data from patients treated for nAMD with anti-vascular endothelial growth factor(VEGF)injections atÖrebro University Hospital between January 2014 and June 2020,were extracted from the Swedish macular register(SMR).A total of 230 eyes were included in the study:116 in the study/bevacizumab switch group and 114 in the control/aflibercept group.Central retinal thickness(CRT)was measured at baseline and after 2y.Primary outcome was mean change in best corrected visual acuity(BCVA)between baseline and 2y.Secondary outcome variables included proportion of patients with a clinically significant change in BCVA[increase or decrease of≥15 Early Treatment Diabetic Retinopathy Study(ETDRS)letters],mean change in CRT,number of anti-VEGF injections,number of visits assessing disease activity and number of visits with active disease.RESULTS:The mean difference in BCVA between baseline and 2y was 1.13±14.47 ETDRS letters in the bevacizumab switch group and 1.81±13.01 ETDRS letters in the aflibercept group.The lower bound of the 95%confidence interval of the difference in BCVA was-4.25,indicating non-inferiority within a 5 ETDRS letter limit.No significant differences in mean change of CRT between baseline and 2y were detected(study-185.9±167.0 versus control-149.4±193.1μm,P=0.127).The distribution of clinically significant improvement(P=0.598)or worsening(P=0.508)of BCVA during follow-up did not show statistically significant differences between groups.The number of anti-VEGF injections administered(study 12.76±2.20 versus control 13.10±4.20,P=0.442),the number of visits assessing disease activity(P=0.301),and the number of visits with active disease(P=0.065)did not show differences between subjects receiving bevacizumab and aflibercept treatment.No significant differences were detected in baseline characteristics between the study and control groups,including age,BCVA,CRT,neovascular membrane type or location,duration of symptoms or prior cataract surgery.CONCLUSION:Switching to off-label bevacizumab in patients responding to initial aflibercept treatment is noninferior to continued aflibercept treatment with respect to change in visual acuity at 2y.Switching anti-VEGF from aflibercept to bevacizumab may be a viable option in clinical settings with limited resources.展开更多
Point source CO_(2) capture(PSCC)is crucial for decarbonizing various industrial sectors,while direct air capture(DAC)holds promise for removing CO_(2) directly from the air.Sorbents play a critical role in both techn...Point source CO_(2) capture(PSCC)is crucial for decarbonizing various industrial sectors,while direct air capture(DAC)holds promise for removing CO_(2) directly from the air.Sorbents play a critical role in both technologies,with their performances,efficiency,cost,etc.,largely depending on which type is used(physical or chemical).Solid amine sorbents(SAS)employed in the chemical adsorption of CO_(2) are suitable for both PSCC and DAC.SAS offer significant advantages over liquid amines such as monoethanolamine(MEA),due to their ability to perform cyclic adsorption–desorption with much lower energy requirement.The environmental concern associated with MEA can be mitigated by SAS.Support materials have a significantly important role in stabilizing amine and enhancing stability and kinetics;varieties of support materials have been screened at a laboratory scale.One promising support material is a silica gel(SG),which is commercially available and attractive for designing cost-effective sorbents for large-scale CO_(2) capture.Various impregnation methods such as physical adsorption and covalent functionalization have been employed to functionalize silica surfaces with amines.This review provided a comprehensive critical analysis of SG-based SAS for CO_(2) capture.We discussed and evaluated them in terms of their adsorption capacity,adsorption,and desorption conditions,and the kinetics involved in these processes.Finally,we proposed a few recommendations for further development of low-cost,lower carbon footprint SAS for large-scale deployment of CO_(2) capture technology.展开更多
Chemical short-range order(SRO),a phenomenon at the atomic scale resulting from inhomogeneities in the local chemical environment,is usually studied using machine learning force field-based molecular dynamics simulati...Chemical short-range order(SRO),a phenomenon at the atomic scale resulting from inhomogeneities in the local chemical environment,is usually studied using machine learning force field-based molecular dynamics simulations due to the limitations of experimental methods.To promote the reliable application of machine potentials in high-entropy alloy simulations,first,this work uses NEP models trained on two different datasets to predict the SRO coefficients of NbMoTaW.The results show that within the same machine learning framework,there are significant differences in the prediction of SRO coefficients for the Nb-Nb atomic pair.Subsequently,this work predicts the SRO coefficients of NbMoTaW using the NEP model and the SNAP model,both of which are trained on the same dataset.The results reveal significant discrepancies in SRO predictions for like-element pairs(e.g.,Nb-Nb and W-W)between the two potentials,despite the identical training data.The findings of this study indicate that discrepancies in the prediction results of SRO coefficients can arise from either the same machine learning framework trained on different datasets or different learning frameworks trained on the same dataset.This reflects possible incompleteness in the current training set's coverage of local chemical environments at the atomic scale.Future research should establish unified evaluation standards to assess the capability of training sets to accurately describe complex atomic-scale behaviors such as SRO.展开更多
This study aimed to model and identify the most productive cutting methods of tree plantations by comparing a forward felling technique(C)with sideways techniques outside(A and D)or inside cutting edge(B and E).Drone ...This study aimed to model and identify the most productive cutting methods of tree plantations by comparing a forward felling technique(C)with sideways techniques outside(A and D)or inside cutting edge(B and E).Drone video material of each tree was analyzed by comparing time distribution of work phases.The relation between this input data and harvester production data was analyzed by regression models.A quadratic model predicted productiv-ity precisely(R^(2)=0.95)and explained the effective-hour productivity in cutting cycle with dummy variables of har-vesting conditions.The productivity was explained by tree size and cutting cycle time,while effects of operator and harvester were eliminated by statistical analysis.In loblolly pine(Pinus taeda L.)plantations on flat terrain,cutting method B was 4.8 m3/E0h(effective working hour)more productive than method A,and 6.7 m^(3)/E0h than method C.In Sydney blue gum(Eucalyptus saligna Sm.)plantations,cutting method E was 1.8 m^(3)/E0h more productive than cut-ting method D on sloping terrain.Of the time-cycle vari-ables,time consumption of the“moving of tree”changed significantly between the cutting methods,of which the ones that used the sideways felling technique inside cutting edge were most efficient.This quadratic modeling structure can be recommended for precise studies in similar harvesting conditions.展开更多
文摘This paper gives insight into the use of underground space in Helsinki,Finland.The city has an underground master plan(UMP) for its whole municipal area,not only for certain parts of the city.Further,the decision-making history of the UMP is described step-by-step.Some examples of underground space use in other cities are also given.The focus of this paper is on the sustainability issues related to urban underground space use,including its contribution to an environmentally sustainable and aesthetically acceptable landscape,anticipated structural longevity and maintaining the opportunity for urban development by future generations.Underground planning enhances overall safety and economy efficiency.The need for underground space use in city areas has grown rapidly since the 21 st century;at the same time,the necessity to control construction work has also increased.The UMP of Helsinki reserves designated space for public and private utilities in various underground areas of bedrock over the long term.The plan also provides the framework for managing and controlling the city’s underground construction work and allows suitable locations to be allocated for underground facilities.Tampere,the third most populated city in Finland and the biggest inland city in the Nordic countries,is also a good example of a city that is taking steps to utilise underground resources.Oulu,the capital city of northern Finland,has also started to ‘go underground’.An example of the possibility to combine two cities by an 80-km subsea tunnel is also discussed.A new fixed link would generate huge potential for the capital areas of Finland and Estonia to become a real Helsinki-Tallinn twin city.
基金supported by the Lanzadera TCUE and C2 program(Universidad de Salamanca)(to ASL)the Spanish National Research Council(CSIC)funded by the Junta de Castilla y León and co-financed by the European Regional Development Fund(ERDF“Europe drives our growth”):Internationalization Project“CL-EI-2021-08-IBFG Unit of Excellence”,Grant(PID2022-138478OA-100)funded by MICIU/AEI/10.13039/501100011033 and,by FEDER,UE(to MGM)+3 种基金Junta de Castilla y León(SA225P23)Gerencia Regional de Salud(2701/A1/2023)(to AV)the Plan Especial Grado Medicina(USAL)(to CPM)a Ramón y Cajal researcher:Grant RYC2021-033684-I funded by MICIU/AEI/10.13039/501100011033 and,by European Union NextGenerationEU/PRTR.
文摘The visual system of teleost fish grows continuously,which is a useful model for studying regeneration of the central nervous system.Glial cells are key for this process,but their contribution is still not well defined.We followed oligodendrocytes in the visual system of adult zebrafish during regeneration of the optic nerve at 6,24,and 72 hours post-lesion and at 7 and 14 days post-lesion via the sox10:tagRFP transgenic line and confocal microscopy.To understand the changes that these oligodendrocytes undergo during regeneration,we used Sox2 immunohistochemistry,a stem cell marker involved in oligodendrocyte differentiation.We also used the Click-iT™ Plus TUNEL assay to study cell death and a BrdU assay to determine cell proliferation.Before optic nerve crush,sox10:tagRFP oligodendrocytes are located in the retina,in the optic nerve head,and through all the entire optic nerve.Sox2-positive cells are present in the peripheral germinal zone,the mature retina,and the optic nerve.After optic nerve crush,sox10:tagRFP cells disappeared from the optic nerve crush zone,suggesting that they died,although they were not TUNEL positive.Concomitantly,the number of Sox2-positive cells increased around the crushed area,the optic nerve head,and the retina.Then,between 24 hours post-lesion and 14 days post-lesion,double sox10:tagRFP/Sox2-positive cells were detected in the retina,optic nerve head,and whole optic nerve,together with a proliferation response at 72 hours post-lesion.Our results confirm that a degenerating process may occur prior to regeneration.First,sox10:tagRFP oligodendrocytes that surround the degenerated axons stop wrapping them,change their“myelinating oligodendrocyte”morphology to a“nonmyelinating oligodendrocyte”morphology,and die.Then,residual oligodendrocyte progenitor cells in the optic nerve and retina proliferate and differentiate for the purpose of remyelination.As new axons arise from the surviving retinal ganglion cells,new sox10:tagRFP oligodendrocytes arise from residual oligodendrocyte progenitor cells to guide,nourish and myelinate them.Thus,oligodendrocytes play an active role in zebrafish axon regeneration and remyelination.
文摘Urban tree species provide various essential ecosystem services in cities,such as regulating urban temperatures,reducing noise,capturing carbon,and mitigating the urban heat island effect.The quality of these services is influenced by species diversity,tree health,and the distribution and the composition of trees.Traditionally,data on urban trees has been collected through field surveys and manual interpretation of remote sensing images.In this study,we evaluated the effectiveness of multispectral airborne laser scanning(ALS)data in classifying 24 common urban roadside tree species in Espoo,Finland.Tree crown structure information,intensity features,and spectral data were used for classification.Eight different machine learning algorithms were tested,with the extra trees(ET)algorithm performing the best,achieving an overall accuracy of 71.7%using multispectral LiDAR data.This result highlights that integrating structural and spectral information within a single framework can improve the classification accuracy.Future research will focus on identifying the most important features for species classification and developing algorithms with greater efficiency and accuracy.
文摘Objectives:Childhood and adolescent obesity are an increasing global health concern.This study aimed to evaluate the effectiveness of digital components and interaction types in counseling interventions for prevention and treatment.Methods:All studies were searched in online databases and grey literature,including PubMed(Medline),Web of Science,CINAHL,Scopus,IEEE Xplore Digital Library,Journal of Medical Internet Research(JMIR),MedNar,EBSco Open Dissertations.The search period is from inception to June 2023,and the languages are Finnish,English and Swedish.The research quality was evaluated using the web-based data management system Covidence for prevalence studies.The study protocol was registered with PROSPERO(registration number:CRD42021247595).Results:In this review,4,407 studies were screened,and 22 were included.These involved 3,433 participants and 264 child-parent pairs.The digital approaches included multicomponent elements like internet platforms,text messaging,video conferencing,online communities,wearable technology,and mobile apps,allowing one-way,two-way,and face-to-face interactions.Two studies showed statistically significant effects of treatment on BMI and waist-to-hip ratio.Most interventions reported positive outcomes,with no significant differences between groups,and none showed null effects during followup.Conclusions:Digital multicomponents like mobile apps and wearables can help obese children and adolescents adopt healthier lifestyles.While these interventions show promise for obesity management,further research is needed to assess their effectiveness,particularly regarding nurses'perspectives.
文摘We review a 3d quantum gravity model, which incorporates massive spinning fields into the Euclidean path integral in a Chern-Simons formulation. Fundamental matter as defined in our previous preon model is recapped. Both quantum gravity and the particle model are shown to be derivable from the supersymmetric 3d Chern-Simons action. Forces-Matter unification is achieved.
文摘The current Tanzanian policy guidelines regarding ecological restoration encourage total protection (enclosure system) against grazing activities, fires and wood extraction to allow regeneration in state-based Miombo woodlands. However, there is little evidence on how such treatments would promote restoration. We fetched the pieces of evidence from studies that evaluated the impact of management treatments on the lightly degraded Miombo woodlands at Kitulangalo Forest Reserve in eastern Tanzania. Plot fencing and fire exclusion constrained woody species regeneration due to competition compared to unfenced plots. Adopting quota grazing policies and controlled burning systems can be the shortest and most eco-friendly pathways towards Miombo restoration. The results pointed out that stand disturbances and silvicultural practices can promote regeneration, which is crucial to promoting ecological restoration in Miombo woodlands.
文摘PurposeThe study aimed to investigate the otology-specific and general health-related quality of life(HRQoL)after cochlear implantation,and scrutinize the variables associated with them.MethodsThe Ear Outcome Survey-16(EOS-16),which assesses ear-specific symptoms and quality of life(QoL),was administered before and after cochlear implantation along with the post-operative administration of the 15D questionnaire that evaluates general HRQoL.The authors investigated post-implantation changes in the EOS-16 total scores and its category responses,examining their relationship with pre-and post-operative hearing levels,speech perception in noise,and the follow-up period length(time elapsed since cochlear implantation).ResultsThere were positive changes noted for the hearing,need for care,and QoL categories of the EOS-16 after implantation.The length of the follow-up period was a significant factor associated with improvements in subjective outcome measures.Changes in self-perceived hearing and HRQoL post-implantation seem independent of pre-and post-implantation hearing performance.ConclusionThese results suggest that while patients regain their hearing abilities shortly after implant activation,their subjective hearing-related benefits and QoL improve over time.
基金supported by the European Union-Next Generation EU instrument and the Research Council of Finland funding(grants 323843,347782,353218,355142,and 357902)INAR RI research infrastructure。
文摘The duration of snow cover has shortened in the boreal region,and the amount of seasonal snow decreased.This affects the coupling between soil and air temperatures and may thus lead to colder soil and deeper soil frost.We prevented snow reaching the forest floor for two winters in mature boreal forest and studied how that affects tree and forest floor processes.The studied species were Scots pine,Norway spruce,silver birch,and a dwarf shrub bilberry.Decreased soil temperature,due to the lack of snow cover,decreased forest floor respiration in winter and spring.Simultaneously,response of respiration to temperature seemed to increase,perhaps due to the exposure of forest floor vegetation to cold air temperature.Indeed,lack of snow cover induced mortality of bilberry,but the remaining ramets grew more in height and their average leaf size was larger likely to compensate for the lost plant biomass.Lack of snow cover also affected tree hydraulics as tree water uptake was decreased in spring,and the start of the sap season delayed in birch.Pine and birch tended to grow less in the snow exclusion treatment(differences not statistically significant),whereas spruce grew more.Coarse root traits,e.g.water content and cellular frost damages,were not affected by the snow exclusion treatment.The results of this case study increase our understanding on the effects of changing snow cover on spring-time tree and forest floor processes in mature boreal forest,but also reveal the need for further studies on mature trees.
文摘AIM:To examine effects of switching intravitreal aflibercept to bevacizumab in neovascular age-related macular degeneration(nAMD).METHODS:Data from patients treated for nAMD with anti-vascular endothelial growth factor(VEGF)injections atÖrebro University Hospital between January 2014 and June 2020,were extracted from the Swedish macular register(SMR).A total of 230 eyes were included in the study:116 in the study/bevacizumab switch group and 114 in the control/aflibercept group.Central retinal thickness(CRT)was measured at baseline and after 2y.Primary outcome was mean change in best corrected visual acuity(BCVA)between baseline and 2y.Secondary outcome variables included proportion of patients with a clinically significant change in BCVA[increase or decrease of≥15 Early Treatment Diabetic Retinopathy Study(ETDRS)letters],mean change in CRT,number of anti-VEGF injections,number of visits assessing disease activity and number of visits with active disease.RESULTS:The mean difference in BCVA between baseline and 2y was 1.13±14.47 ETDRS letters in the bevacizumab switch group and 1.81±13.01 ETDRS letters in the aflibercept group.The lower bound of the 95%confidence interval of the difference in BCVA was-4.25,indicating non-inferiority within a 5 ETDRS letter limit.No significant differences in mean change of CRT between baseline and 2y were detected(study-185.9±167.0 versus control-149.4±193.1μm,P=0.127).The distribution of clinically significant improvement(P=0.598)or worsening(P=0.508)of BCVA during follow-up did not show statistically significant differences between groups.The number of anti-VEGF injections administered(study 12.76±2.20 versus control 13.10±4.20,P=0.442),the number of visits assessing disease activity(P=0.301),and the number of visits with active disease(P=0.065)did not show differences between subjects receiving bevacizumab and aflibercept treatment.No significant differences were detected in baseline characteristics between the study and control groups,including age,BCVA,CRT,neovascular membrane type or location,duration of symptoms or prior cataract surgery.CONCLUSION:Switching to off-label bevacizumab in patients responding to initial aflibercept treatment is noninferior to continued aflibercept treatment with respect to change in visual acuity at 2y.Switching anti-VEGF from aflibercept to bevacizumab may be a viable option in clinical settings with limited resources.
基金financial support from Business Finland 8205/31/2022the Magnus Ehrnrooth Foundation for financial support.
文摘Point source CO_(2) capture(PSCC)is crucial for decarbonizing various industrial sectors,while direct air capture(DAC)holds promise for removing CO_(2) directly from the air.Sorbents play a critical role in both technologies,with their performances,efficiency,cost,etc.,largely depending on which type is used(physical or chemical).Solid amine sorbents(SAS)employed in the chemical adsorption of CO_(2) are suitable for both PSCC and DAC.SAS offer significant advantages over liquid amines such as monoethanolamine(MEA),due to their ability to perform cyclic adsorption–desorption with much lower energy requirement.The environmental concern associated with MEA can be mitigated by SAS.Support materials have a significantly important role in stabilizing amine and enhancing stability and kinetics;varieties of support materials have been screened at a laboratory scale.One promising support material is a silica gel(SG),which is commercially available and attractive for designing cost-effective sorbents for large-scale CO_(2) capture.Various impregnation methods such as physical adsorption and covalent functionalization have been employed to functionalize silica surfaces with amines.This review provided a comprehensive critical analysis of SG-based SAS for CO_(2) capture.We discussed and evaluated them in terms of their adsorption capacity,adsorption,and desorption conditions,and the kinetics involved in these processes.Finally,we proposed a few recommendations for further development of low-cost,lower carbon footprint SAS for large-scale deployment of CO_(2) capture technology.
基金Project supported by the Hunan Provincial Natural Science Foundation(Grant Nos.2024JJ6190 and 2024JK2007-1)。
文摘Chemical short-range order(SRO),a phenomenon at the atomic scale resulting from inhomogeneities in the local chemical environment,is usually studied using machine learning force field-based molecular dynamics simulations due to the limitations of experimental methods.To promote the reliable application of machine potentials in high-entropy alloy simulations,first,this work uses NEP models trained on two different datasets to predict the SRO coefficients of NbMoTaW.The results show that within the same machine learning framework,there are significant differences in the prediction of SRO coefficients for the Nb-Nb atomic pair.Subsequently,this work predicts the SRO coefficients of NbMoTaW using the NEP model and the SNAP model,both of which are trained on the same dataset.The results reveal significant discrepancies in SRO predictions for like-element pairs(e.g.,Nb-Nb and W-W)between the two potentials,despite the identical training data.The findings of this study indicate that discrepancies in the prediction results of SRO coefficients can arise from either the same machine learning framework trained on different datasets or different learning frameworks trained on the same dataset.This reflects possible incompleteness in the current training set's coverage of local chemical environments at the atomic scale.Future research should establish unified evaluation standards to assess the capability of training sets to accurately describe complex atomic-scale behaviors such as SRO.
文摘This study aimed to model and identify the most productive cutting methods of tree plantations by comparing a forward felling technique(C)with sideways techniques outside(A and D)or inside cutting edge(B and E).Drone video material of each tree was analyzed by comparing time distribution of work phases.The relation between this input data and harvester production data was analyzed by regression models.A quadratic model predicted productiv-ity precisely(R^(2)=0.95)and explained the effective-hour productivity in cutting cycle with dummy variables of har-vesting conditions.The productivity was explained by tree size and cutting cycle time,while effects of operator and harvester were eliminated by statistical analysis.In loblolly pine(Pinus taeda L.)plantations on flat terrain,cutting method B was 4.8 m3/E0h(effective working hour)more productive than method A,and 6.7 m^(3)/E0h than method C.In Sydney blue gum(Eucalyptus saligna Sm.)plantations,cutting method E was 1.8 m^(3)/E0h more productive than cut-ting method D on sloping terrain.Of the time-cycle vari-ables,time consumption of the“moving of tree”changed significantly between the cutting methods,of which the ones that used the sideways felling technique inside cutting edge were most efficient.This quadratic modeling structure can be recommended for precise studies in similar harvesting conditions.
