This report is about the first record of non-avian dinosaur eggs in the Hefei Basin,Anhui Province,China.Based on the combination of elongated egg body,linear ridges on the outer surface and two structure layer,the eg...This report is about the first record of non-avian dinosaur eggs in the Hefei Basin,Anhui Province,China.Based on the combination of elongated egg body,linear ridges on the outer surface and two structure layer,the eggs can be referred to Elongatoolithidae.The gradual boundary between the cone and the column layers as well as the relative thin eggshell(less than 1 mm)indicates its affinity within Elongatoolithus.The eggs are identified as Elongatoolithus oosp.,as they were severely compressed and experienced erosion on both inner and outer surfaces.The discovery of egg fossil in the Hefei Basin offers evidence for stratum comparison in this region and supplements the diversity of egg fossils in Anhui.Meanwhile,this discovery also enriches the paleogeographic distribution of elongatoolithids.展开更多
Extreme ozone pollution events(EOPEs)are associated with synoptic weather patterns(SWPs)and pose severe health and ecological risks.However,a systematic investigation of themeteorological causes,transport pathways,and...Extreme ozone pollution events(EOPEs)are associated with synoptic weather patterns(SWPs)and pose severe health and ecological risks.However,a systematic investigation of themeteorological causes,transport pathways,and source contributions to historical EOPEs is still lacking.In this paper,the K-means clustering method is applied to identify six dominant SWPs during the warm season in the Yangtze River Delta(YRD)region from 2016 to 2022.It provides an integrated analysis of the meteorological factors affecting ozone pollution in Hefei under different SWPs.Using the WRF-FLEXPART model,the transport pathways(TPPs)and geographical sources of the near-surface air masses in Hefei during EOPEs are investigated.The results reveal that Hefei experienced the highest ozone concentration(134.77±42.82μg/m^(3)),exceedance frequency(46 days(23.23%)),and proportion of EOPEs(21 instances,47.7%)under the control of peripheral subsidence of typhoon(Type 5).Regional southeast winds correlated with the ozone pollution in Hefei.During EOPEs,a high boundary layer height,solar radiation,and temperature;lowhumidity and cloud cover;and pronounced subsidence airflow occurred over Hefei and the broader YRD region.The East-South(E_S)patterns exhibited the highest frequency(28 instances,65.11%).Regarding the TPPs and geographical sources of the near-surface air masses during historical EOPEs.The YRD was the main source for land-originating air masses under E_S patterns(50.28%),with Hefei,southern Anhui,southern Jiangsu,and northern Zhejiang being key contributors.These findings can help improve ozone pollution early warning and control mechanisms at urban and regional scales.展开更多
The Tan-Lu Fault Zone is a large NNE-trending fault zone that has a substantial effect on the development of eastern China and its earthquake disaster prevention efforts. Aiming at the azimuthally anisotropic structur...The Tan-Lu Fault Zone is a large NNE-trending fault zone that has a substantial effect on the development of eastern China and its earthquake disaster prevention efforts. Aiming at the azimuthally anisotropic structure in the upper crust and seismogenic tectonics in the Hefei segment of this fault, we collected phase velocity dispersion data of fundamental mode Rayleigh waves from ambient noise cross-correlation functions of ~400 temporal seismographs in an area of approximately 80 × 70 km along the fault zone. The period band of the dispersion data was ~0.5–10 s. We inverted for the upper crustal three-dimensional(3-D) shear velocity model with azimuthal anisotropy from the surface to 10 km depth by using a 3-D direct azimuthal anisotropy inversion method. The inversion result shows the spatial distribution characteristics of the tectonic units in the upper crust. Additionally, the deformation of the Tan-Lu Fault Zone and its conjugated fault systems could be inferred from the anisotropy model. In particular, the faults that have remained active from the early and middle Pleistocene control the anisotropic characteristics of the upper crustal structure in this area. The direction of fast axes near the fault zone area in the upper crust is consistent with the strike of the faults, whereas for the region far away from the fault zone, the direction of fast axes is consistent with the direction of the regional principal stress caused by plate movement. Combined with the azimuthal anisotropy models in the deep crust and uppermost mantle from the surface wave and Pn wave, the different anisotropic patterns caused by the Tan-Lu Fault Zone and its conjugated fault system nearby are shown in the upper and lower crust. Furthermore,by using the double-difference method, we relocated the Lujiang earthquake series, which contained 32 earthquakes with a depth shallower than 10 km. Both the Vs model and earthquake relocation results indicate that earthquakes mostly occurred in the vicinity of structural boundaries with fractured media, with high-level development of cracks and small-scale faults jammed between more rigid areas.展开更多
Neurodegenerative diseases,which are characterized by progressive neuronal loss and the lack of disease-modifying therapies,are becoming a major global health challenge.The existing neuromodulation techniques,such as ...Neurodegenerative diseases,which are characterized by progressive neuronal loss and the lack of disease-modifying therapies,are becoming a major global health challenge.The existing neuromodulation techniques,such as deep brain stimulation and transcranial magnetic stimulation,show limitations such as invasiveness,restricted cortical targeting,and irreversible tissue effects.In this context,low-intensity transcranial ultrasound has emerged as a promising noninvasive alternative that can penetrate deep into the brain and modulate neuroplasticity.This review comprehensively assesses the therapeutic mechanisms,efficacy,and translational potential of low-intensity transcranial ultrasound in treating neurodegenerative diseases,with emphasis on its role in promoting neuronal regeneration,modulating neuroinflammation,and enhancing functional recovery.We summarize the findings of previous studies and systematically illustrate the potential of low-intensity transcranial ultrasound in regulating cell death mechanisms,enhancing neural repair and regeneration,and alleviating symptoms associated with neurodegenerative diseases.Preclinical findings indicate that low-intensity transcranial ultrasound can enhance the release of neurotrophic factors(e.g.,brain-derived neurotrophic factor),promote autophagy to clear protein aggregates,modulate microglial activation,and temporarily open the blood-brain barrier to facilitate targeted drug delivery.Existing clinical trial data show that low-intensity transcranial ultrasound can reduce amyloid-βplaques,improve motor and cognitive deficits,and promote remyelination in various disease models.Early clinical trials suggest that low-intensity transcranial ultrasound may enhance cognitive scores in Alzheimer’s disease and alleviate motor symptoms in Parkinson’s disease,all while demonstrating a favorable safety profile.Past studies support the notion that by integrating safety,precision,and reversibility,low-intensity transcranial ultrasound can transform the treatment landscape for neurodegenerative disease.However,more advancements are necessary for future clinical application of low-intensity transcranial ultrasound,including optimizing parameters such as frequency,intensity,and duty cycle;considering individual anatomical differences;and confirming long-term efficacy.We believe establishing standardized protocols,conducting larger trials,and investigating the underlying mechanisms to clarify dose-response relationships and refine personalized application strategies are essential in this regard.Future research should focus on translating preclinical findings into clinical practice,addressing technical challenges,and exploring combination therapies with pharmacological or gene interventions.展开更多
The stability of the plane grating monochromator in the Hefei Advanced Light Facility is highly important for beamline focusing,with angular vibration being a key indicator for assessing its stability.This paper propo...The stability of the plane grating monochromator in the Hefei Advanced Light Facility is highly important for beamline focusing,with angular vibration being a key indicator for assessing its stability.This paper proposes an elastic fitting method based on fifth-order polynomial fitting for the precise analysis of microangular vibrations on grating surfaces.Compared with the traditional rigid body method,this method fully considers the three major elastic characteristics exhibited by optical components during vibration:significant phase differences,nonuniform deformation gradients,and spatial distribution differences in angular deformation.The research results indicate that this method can accurately reflect the actual vibration state of the grating surface,not only enabling the quantitative prediction of local angular microvibration but also establishing a reliable theoretical analysis framework for the stability assessment of high-precision instruments.展开更多
The longitudinal π-extension of carbon nanohoops is one of the most effective bottom-up synthetic strategies toward carbon nanotubes(CNTs).Herein,the precise synthesis of a multi-substituted carbon nanohoop([12]CPP-8...The longitudinal π-extension of carbon nanohoops is one of the most effective bottom-up synthetic strategies toward carbon nanotubes(CNTs).Herein,the precise synthesis of a multi-substituted carbon nanohoop([12]CPP-8PBPy)based on cycloparaphenylenes(CPPs)grafted with eight pyrene-functionalized units was reported.This structurally well-defined nanohoop not only acts as a segment of armchair-type CNTs but also achieves enhanced longitudinal π-extension.The structure of[12]CPP-8PBPy was confirmed by high-resolution mass spectrometry(HRMS)and nuclear magnetic resonance(NMR).The photophysical properties were studied by UV/Vis and photoluminescence spectroscopy.The potential applications of[12]CPP-8PBPy in electron-transport devices were further investigated.展开更多
A detailed investigation was carried out to understand how the variations in configurations of the spiroannulated 6-6-6-5-5 pentacyclic diastereoisomers,the key intermediates for the synthesis of two C30 terpene quino...A detailed investigation was carried out to understand how the variations in configurations of the spiroannulated 6-6-6-5-5 pentacyclic diastereoisomers,the key intermediates for the synthesis of two C30 terpene quinonemethides and their stereoisomers,impact the reactivity of cyclopropanation.The configurations at C9,C8,and C14 for all four pentacyclic diastereoisomers involved in the diastereoisomeric mixture were determined through a combination of suitable chemical derivatization and multiple NMR spectroscopic analyses.Based on the defined configuration,the 3D structures of these diastereoisomers were optimized by density functional theory(DFT)calculation.These investigations provide reasonable supports,mainly from the steric considerations,for understanding why different diastereoisomers exhibit markedly different reactivity,as well as regio-and stereo-selectivity for cyclopropanation.In addition,the mechanism for the construction of the spiroannulated 6-6-6-5-5 pentacyclic scaffold via intramolecular Michael/aldol cascade was also investigated by deuterium labeling experiments.展开更多
In this study,a novel polysaccharide GPA-G 2-H was derived from ginseng.Furthermore,the coherent study of its structural characteristics,fermented characteristics in vitro,as well as antioxidant mechanism of fermented...In this study,a novel polysaccharide GPA-G 2-H was derived from ginseng.Furthermore,the coherent study of its structural characteristics,fermented characteristics in vitro,as well as antioxidant mechanism of fermented product FGPA-G 2-H on Aβ25-35-induced PC 12 cells were explored.The structure of GPA-G 2-H was determined by means of zeta potential analysis,FTIR,HPLC,XRD,GC-MS and NMR.The backbone of GPA-G 2-H was mainly composed of→4)-α-D-Glcp-(1→with branches substituted at O-3.Notably,GPA-G 2-H was degraded by intestinal microbiota in vitro with total sugar content and pH value decreasing,and short-chain fatty acids(SCFAs)increasing.Moreover,GPA-G 2-H significantly promoted the proliferation of Lactobacillus,Muribaculaceae and Weissella,thereby making positive alterations in intestinal microbiota composition.Additionally,FGPA-G 2-H activated the Nrf 2/HO-1 signaling pathway,enhanced HO-1,NQO 1,SOD and GSH-Px,while inhabited Keap 1,MDA and LDH,which alleviated Aβ-induced oxidative stress in PC 12 cells.These provide a solid theoretical basis for the further development of ginseng polysaccharides as functional food and antioxidant drugs.展开更多
Ischemic stroke represents a significant global health challenge,frequently associated with intricate pathophysiological alterations.During ischemic stroke,the generation of reactive oxygen species markedly increases,...Ischemic stroke represents a significant global health challenge,frequently associated with intricate pathophysiological alterations.During ischemic stroke,the generation of reactive oxygen species markedly increases,leading to direct neuronal damage as well as initiating a cascade of inflammatory responses.This oxidative stress can also disturb the equilibrium of the gut microbiota,resulting in dysbiosis.In turn,an imbalance in gut microbiota can further exacerbate the production of reactive oxygen species and contribute to a pro-inflammatory environment within the body.This creates a vicious cycle that not only promotes the progression of stroke but also leads to adverse functional outcomes.The neuroinflammation and intestinal microbiota dysbiosis that occur following ischemic stroke are critical contributors to stroke progression and adverse functional outcomes.We previously developed manganese-iron Prussian blue nanozymes,characterized by a multi-enzyme structure and a porous design,that exhibit strong antioxidant properties.However,the therapeutic effects of manganese-iron Prussian blue nanozymes on ischemic stroke and their mechanisms of action remain have not been fully elucidated.To investigate this,we constructed a mouse model of middle cerebral artery occlusion and administered manganese-iron Prussian blue nanozymes via gastric gavage.Our results demonstrated that these nanozymes substantially reduced infarct volume,improved neurological function,restored gut microbiota balance,and increased levels of short-chain fatty acids in the mouse model.Treatment of lipopolysaccharide-treated BV-2 cells with short-chain fatty acids markedly decreased the expression levels of components of the Toll-like receptor 4/nuclear factor kappa B signaling pathway,including Toll-like receptor 4,inhibitor of nuclear factor kappa-B kinase subunit alpha,and pp65.These findings suggest that manganese-iron Prussian blue nanozymes can correct gut microbiota dysbiosis and increase short-chain fatty acid production by modulating the Toll-like receptor 4/nuclear factor kappa B signaling pathway,thereby providing therapeutic benefits in the context of ischemic stroke.展开更多
Programmable two-particle quantum walks are crucial for advancing quantum simulation,computation,and information processing.Although disorder is traditionally associated with information loss,it can also facilitate em...Programmable two-particle quantum walks are crucial for advancing quantum simulation,computation,and information processing.Although disorder is traditionally associated with information loss,it can also facilitate emergent phenomena such as enhanced energy transport.Here,we experimentally realize a 12-step discrete-time quantum walk in programmable integrated photonic circuits,introducing tunable static and dynamic disorder to explore quantum transport dynamics.In periodic lattices,disorder induces light localization and drives a transition from quantum ballistic to classical diffusive behavior.In particular,quantum walks of correlated photons exhibit a disorder-induced bunching effect,accompanied by enhanced nonclassical correlations.Our platform provides a scalable framework for investigating multiparticle quantum dynamics in engineered environments,promoting the development of quantum optics toward large-scale applications.展开更多
Vitamin D deficiency(VDD)represents a significant nutritional concern among children and adolescents.The estimated prevalence of VDD in China is 46.8%in this population^([1]).VDD during childhood and adolescence has b...Vitamin D deficiency(VDD)represents a significant nutritional concern among children and adolescents.The estimated prevalence of VDD in China is 46.8%in this population^([1]).VDD during childhood and adolescence has been associated with the onset of various conditions,including acute respiratory infections,asthma,atopic dermatitis,and food allergies^([2]).Multiple factors,including age,sun exposure,adiposity,and genetics,influence vitamin D levels^([2,3]).Increasing attention has been directed toward understanding the environmental determinants that may influence vitamin D status.Given the potential of metallic pollutants to disrupt endocrine function and their ubiquity in the environment,investigating the effects of metal exposure on human vitamin D status,particularly in vulnerable populations,is imperative.展开更多
In this work,we develop an extended dissipaton theory that generalizes the environmental couplings beyond the conventional linear and quadratic forms,enabling the treatment of ar-bitrary order of bath couplings.Ap-ply...In this work,we develop an extended dissipaton theory that generalizes the environmental couplings beyond the conventional linear and quadratic forms,enabling the treatment of ar-bitrary order of bath couplings.Ap-plying this theoretical framework to the condensed-phase non-Condon spectroscopy,we demonstrate the in-terplay of anharmonicity,non-Con-don and solvent effects on optical spectra,where the higher-order cou-plings arise from the anharmonicity of nuclear potential surface of the excited state.Precise simulations are carried out with high efficiency on linear absorption spectra involving the above mentioned correlated effects.We exhibit how an anharmonic potential modulates the vibronic feature,offering insights into the role of nonlinear environmental couplings in spectroscopic signatures and exemplifying the success of the extended dissipaton formalism as an exact and efficient method for higher-or-der bath couplings.展开更多
Background Undernutrition disrupts pregnant ewe's metabolic homeostasis and severely inhibits fetal growth and development.In this study,undernourished and nutrition-recovery pregnant sheep models and rumen epithe...Background Undernutrition disrupts pregnant ewe's metabolic homeostasis and severely inhibits fetal growth and development.In this study,undernourished and nutrition-recovery pregnant sheep models and rumen epithelial cells were utilized to investigate the mechanisms behind undernutrition-induced disruptions in male fetal rumen metabolism and development.Results Maternal undernutrition significantly reduced male fetal rumen weight and papilla length,width and surface area.Maternal undernutrition extremely suppressed nutrient metabolism and energy production in male fetal rumen via JAK3/STAT3 signaling to inhibit cell cycle progression and male fetal rumen development,while maternal nutritional recovery partially restored metabolic inhibition but failed to alleviate male fetal rumen development.Meanwhile,64 differentially expressed miRNAs(DEMs)were identified in male fetal rumen between undernourished ewes and controls.Novel miR-736 was overexpressed both in male fetal rumen of undernourished and nutrition-recovery models.E2F transcription factor 2(E2F2)and MYB proto-oncogene like 2(MYBL2)were the intersection of male fetal rumen differentially expressed genes(DEGs)and DEMs target genes integrated analysis and were predicted as novel miR-736 target genes.Further,we confirmed that novel miR-736 targeted and downregulated E2F2 and MYBL2 expression levels.Silencing E2F2 and MYBL2 promoted apoptosis and inhibited S-phase entry in rumen epithelial cells.Conclusions In summary,maternal undernutrition disrupted male fetal rumen metabolism and elevated novel miR-736,which targeted and downregulated E2F2 and MYBL2 to inhibit cell cycle progression and promote apoptosis,finally inhibited male fetal rumen development.This study provides new insights into the epigenetic mechanisms underlying maternal undernutrition-induced male fetal rumen developmental deficits.展开更多
The development of epoxy(EP)nanocomposites has emerged as a prominent research area across diverse sectors,including automotive,construction,and aerospace industries.Recently,adopting biomimetic strategies for the pre...The development of epoxy(EP)nanocomposites has emerged as a prominent research area across diverse sectors,including automotive,construction,and aerospace industries.Recently,adopting biomimetic strategies for the preparation of nanomaterials to design multifunctional epoxy resins has emerged as a prominent research hotspot.Inspired by the growth pattern of coral reefs,this study successfully engineered a novel hierarchical nanostructured material(Fe-NiPS-PBA)with the aim of creating EP nanocomposites that exhibit highly flame-retardant efficiency,exceptional mechanical strength,and distinguished wear-resisting property even at low additive concentrations.With a 3 wt%addition of Fe-NiPS-PBA,the limiting oxygen index of the EP/3Fe-NiPS-PBA nanocomposite increased from 23.5 to 25.9,achieving a UL-94 V-0 rating.Compared to pure EP,EP/3Fe-NiPSPBA nanocomposite reduced the peak heat release rate(PHRR),total heat release(THR),peak smoke production rate(PSPR),total smoke production(TSP),and maximum CO emission(MCO)by 44.1%,66.7%,47.0%,67.8%,and 51.7%,respectively.Moreover,the incorporation of a 1 wt%additive resulted in significant enhancements of tensile strength from 76.7 MPa to 96.9 MPa,while the wear rate demonstrated a remarkable reduction of 77.8%.The Fe-NiPS-PBA significantly enhanced the fire performance and mechanical strength of EP nanocomposites,demonstrating exceptional overall performance in various applications.展开更多
The integration of accurate detection and immediate bactericidal in a single platform significantly enhances pathogen monitoring and control capabilities,but nanomaterial functional compatibility remains a major chall...The integration of accurate detection and immediate bactericidal in a single platform significantly enhances pathogen monitoring and control capabilities,but nanomaterial functional compatibility remains a major challenge.Here,we developed a multifunctional nanoplatform integrating multimode flexible detection and magnetic aggregation-induced sterilization by utilizing the synergistic effect of quinone-phenol grafting nanozymes loaded with Pt single atoms(Pt SA@Q-ACDs)and magnetic carbon dots(Fe_(3)O_(4)@DCDs).In Pt SA@Q-ACDs,Pt SA increased the electron transfer from the quinone-phenol system,and the hydroxyl and pyridine state N defects sequentially synergized to form a double anchor site,the energy barrier for reducing H_(2)O_(2) was reduced,constituting a"1+1>2"bicatalytic system,which improved signal output and sterilization efficiency.Fe_(3)O_(4)@DCD enriches target bacteria through magnetic induction,dramatically reduces background interference,and increases the sterilization efficiency to 100%while realizing the detection of pathogenic bacteria at the single-cell level.Complementing this,we designed an intelligent portable device capable of dynamically switching and interpreting multimodal signals,enabling adaptable field deployment.The multifunctional platform can realize early warning from food processing to the terminal,combined with high bactericidal efficiency,and can implement"closed-loop monitoring"for pathogenic bacteria in an all-round way,which has great potential.展开更多
Nanoscale red phosphorus(NRP)was synthesized via a phosphorus-amine dissolution method and immobilized onto mesoporous silica nanospheres(MSNs)to obtain hybrid NRP@MSN particles with improved dispersion stability.Epox...Nanoscale red phosphorus(NRP)was synthesized via a phosphorus-amine dissolution method and immobilized onto mesoporous silica nanospheres(MSNs)to obtain hybrid NRP@MSN particles with improved dispersion stability.Epoxy resin(EP)composites containing 2 wt%fillers were prepared to evaluate their thermal and flame-retardant behaviors.Compared with EP,the NRP@MSNs/EP composite significantly enhanced fire safety,resulting in a 52.8%reduction in the peak heat release rate,a 13.9%decrease in total smoke production,and a 165%increase in char yield.Mechanical testing revealed a notable toughening effect under impact loading.The improved flame retardancy originates from the combined nano-barrier effect of MSNs and the catalytic charring and radical-quenching functions of NRP.This work demonstrates an efficient strategy for stabilizing NRP and highlights its strong potential as an environmentally friendly flame retardant for EP systems.展开更多
Flexible electronics face critical challenges in achieving monolithic three-dimensional(3D)integration,including material compatibility,structural stability,and scalable fabrication methods.Inspired by the tactile sen...Flexible electronics face critical challenges in achieving monolithic three-dimensional(3D)integration,including material compatibility,structural stability,and scalable fabrication methods.Inspired by the tactile sensing mechanism of the human skin,we have developed a flexible monolithic 3D-integrated tactile sensing system based on a holey MXene paste,where each vertical one-body unit simultaneously functions as a microsupercapacitor and pressure sensor.The in-plane mesopores of MXene significantly improve ion accessibility,mitigate the self-stacking of nanosheets,and allow the holey MXene to multifunctionally act as a sensing material,an active electrode,and a conductive interconnect,thus drastically reducing the interface mismatch and enhancing the mechanical robustness.Furthermore,we fabricate a large-scale device using a blade-coating and stamping method,which demonstrates excellent mechanical flexibility,low-power consumption,rapid response,and stable long-term operation.As a proof-of-concept application,we integrate our sensing array into a smart access control system,leveraging deep learning to accurately identify users based on their unique pressing behaviors.This study provides a promising approach for designing highly integrated,intelligent,and flexible electronic systems for advanced human-computer interactions and personalized electronics.展开更多
Acute eosinophilic pneumonia(AEP) is a pulmonary condition characterized by acute febrile illness and respiratory distress,with bilateral pulmonary infiltrates,particularly eosinophilic infiltration of the lungs.^([1]...Acute eosinophilic pneumonia(AEP) is a pulmonary condition characterized by acute febrile illness and respiratory distress,with bilateral pulmonary infiltrates,particularly eosinophilic infiltration of the lungs.^([1])Amiodarone,a widely applied antiarrhythmic agent,has been reported as a potential cause of drug-induced AEP.^([2]) Most reported cases of amiodarone-induced AEP typically occur following prolonged exposure for two months or more.展开更多
Chemotherapeutic paclitaxel(PTX) formulations are widely used in clinical cancer treatment;however, they are also associated with concomitant programmed death-ligand(PD-L1) upregulation and an immunosuppressive microe...Chemotherapeutic paclitaxel(PTX) formulations are widely used in clinical cancer treatment;however, they are also associated with concomitant programmed death-ligand(PD-L1) upregulation and an immunosuppressive microenvironment. Herein, we rationally designed carrier-free, reduction-sensitive PTX dimer self-assembling nanoprodrugs(di PC NPs), composed of a glutathione(GSH)-responsive PTX dimer prodrug(di PTX) and the PD-L1 downregulator celastrol(Cel) for combinational chemoimmunotherapy. Following intravenous administration, the di PC NPs exhibited prolonged blood circulation and preferential tumor accumulation by exploiting the enhanced permeability and retention effect. Subsequently, the elevated GSH levels in tumor cells cleaved the disulfide bonds,triggering the rapid release of PTX and Cel. The released PTX elicited potent cytotoxic effects and induced immunogenic cell death(ICD), whereas the released Cel synergistically enhanced ICD and downregulated PD-L1 expression in tumor cells. Together, these effects resulted in remarkable antitumor efficacy with exhibited a favorable safety profile within the therapeutic window in both Lewis lung carcinoma cells and B16F10 tumorbearing mice. Our findings highlight a promising strategy for highly efficient combination chemoimmunotherapy.展开更多
To maintain air quality during the 31st World University Games,Chengdu employed a range of monitoring and control strategies in 2023.High-resolution regional pollutant distributions were reconstructed by integrating t...To maintain air quality during the 31st World University Games,Chengdu employed a range of monitoring and control strategies in 2023.High-resolution regional pollutant distributions were reconstructed by integrating the vertical column densities(VCDs)from mobile MAX-DOAS measurements with Gaussian process regression analysis.The correlation between the spatial distribution derived from MAX-DOAS and that of GEMS and TROPOMI satellite data exceeded 0.6.This paper explores the impact of air quality improvements during the games on the sources of HCHO and the formation process of HONO.During the control period,primary emissions and secondary formations of HCHO contributed 50.85%±24.24%and 42.81%±7.57%to the total atmospheric HCHO,respectively.The study indicates that with improved air quality,HCHO primary emissions decrease while secondary emissions and atmospheric radiation transmission intensities rise.It is found that HONO always appears under the condition of high aerosol optical depth(AOD)and NO_(2),but high NO_(2) concentration and AOD are not necessarily accompanied by high concentrations of HONO.To assess the influence of temperature and humidity on the formation of HONO from NO_(2),we calculated the emission ratesΔHONO∕ΔNO_(2) to quantify the impact of primary sources on total HONO concentrations.The analysis results show that the turning point of relative humidity is 65%(60%–70%)and the turning point of temperature is 31℃(30–32℃).Lower temperatures and higher humidity levels were found to decrease the rate of secondary HONO formation from NO_(2).展开更多
文摘This report is about the first record of non-avian dinosaur eggs in the Hefei Basin,Anhui Province,China.Based on the combination of elongated egg body,linear ridges on the outer surface and two structure layer,the eggs can be referred to Elongatoolithidae.The gradual boundary between the cone and the column layers as well as the relative thin eggshell(less than 1 mm)indicates its affinity within Elongatoolithus.The eggs are identified as Elongatoolithus oosp.,as they were severely compressed and experienced erosion on both inner and outer surfaces.The discovery of egg fossil in the Hefei Basin offers evidence for stratum comparison in this region and supplements the diversity of egg fossils in Anhui.Meanwhile,this discovery also enriches the paleogeographic distribution of elongatoolithids.
基金supported by the National Natural Science Foundation of China(Nos.U19A2044,42105132,42030609,and 41975037)the National Key Research and Development Programof China(No.2022YFC3700303).
文摘Extreme ozone pollution events(EOPEs)are associated with synoptic weather patterns(SWPs)and pose severe health and ecological risks.However,a systematic investigation of themeteorological causes,transport pathways,and source contributions to historical EOPEs is still lacking.In this paper,the K-means clustering method is applied to identify six dominant SWPs during the warm season in the Yangtze River Delta(YRD)region from 2016 to 2022.It provides an integrated analysis of the meteorological factors affecting ozone pollution in Hefei under different SWPs.Using the WRF-FLEXPART model,the transport pathways(TPPs)and geographical sources of the near-surface air masses in Hefei during EOPEs are investigated.The results reveal that Hefei experienced the highest ozone concentration(134.77±42.82μg/m^(3)),exceedance frequency(46 days(23.23%)),and proportion of EOPEs(21 instances,47.7%)under the control of peripheral subsidence of typhoon(Type 5).Regional southeast winds correlated with the ozone pollution in Hefei.During EOPEs,a high boundary layer height,solar radiation,and temperature;lowhumidity and cloud cover;and pronounced subsidence airflow occurred over Hefei and the broader YRD region.The East-South(E_S)patterns exhibited the highest frequency(28 instances,65.11%).Regarding the TPPs and geographical sources of the near-surface air masses during historical EOPEs.The YRD was the main source for land-originating air masses under E_S patterns(50.28%),with Hefei,southern Anhui,southern Jiangsu,and northern Zhejiang being key contributors.These findings can help improve ozone pollution early warning and control mechanisms at urban and regional scales.
基金financially supported by the National Key Research and Development Program of China (2022YFC3005600)the Foundation of the Anhui Educational Commission (2023AH051198)+1 种基金the National Natural Science Foundation of China (42125401 and 42104063)the Joint Open Fund of Mengcheng National Geophysical Observatory (MENGO-202201)。
文摘The Tan-Lu Fault Zone is a large NNE-trending fault zone that has a substantial effect on the development of eastern China and its earthquake disaster prevention efforts. Aiming at the azimuthally anisotropic structure in the upper crust and seismogenic tectonics in the Hefei segment of this fault, we collected phase velocity dispersion data of fundamental mode Rayleigh waves from ambient noise cross-correlation functions of ~400 temporal seismographs in an area of approximately 80 × 70 km along the fault zone. The period band of the dispersion data was ~0.5–10 s. We inverted for the upper crustal three-dimensional(3-D) shear velocity model with azimuthal anisotropy from the surface to 10 km depth by using a 3-D direct azimuthal anisotropy inversion method. The inversion result shows the spatial distribution characteristics of the tectonic units in the upper crust. Additionally, the deformation of the Tan-Lu Fault Zone and its conjugated fault systems could be inferred from the anisotropy model. In particular, the faults that have remained active from the early and middle Pleistocene control the anisotropic characteristics of the upper crustal structure in this area. The direction of fast axes near the fault zone area in the upper crust is consistent with the strike of the faults, whereas for the region far away from the fault zone, the direction of fast axes is consistent with the direction of the regional principal stress caused by plate movement. Combined with the azimuthal anisotropy models in the deep crust and uppermost mantle from the surface wave and Pn wave, the different anisotropic patterns caused by the Tan-Lu Fault Zone and its conjugated fault system nearby are shown in the upper and lower crust. Furthermore,by using the double-difference method, we relocated the Lujiang earthquake series, which contained 32 earthquakes with a depth shallower than 10 km. Both the Vs model and earthquake relocation results indicate that earthquakes mostly occurred in the vicinity of structural boundaries with fractured media, with high-level development of cracks and small-scale faults jammed between more rigid areas.
基金supported by STI2030-Major Project,No,2021ZD0204200(to LX).
文摘Neurodegenerative diseases,which are characterized by progressive neuronal loss and the lack of disease-modifying therapies,are becoming a major global health challenge.The existing neuromodulation techniques,such as deep brain stimulation and transcranial magnetic stimulation,show limitations such as invasiveness,restricted cortical targeting,and irreversible tissue effects.In this context,low-intensity transcranial ultrasound has emerged as a promising noninvasive alternative that can penetrate deep into the brain and modulate neuroplasticity.This review comprehensively assesses the therapeutic mechanisms,efficacy,and translational potential of low-intensity transcranial ultrasound in treating neurodegenerative diseases,with emphasis on its role in promoting neuronal regeneration,modulating neuroinflammation,and enhancing functional recovery.We summarize the findings of previous studies and systematically illustrate the potential of low-intensity transcranial ultrasound in regulating cell death mechanisms,enhancing neural repair and regeneration,and alleviating symptoms associated with neurodegenerative diseases.Preclinical findings indicate that low-intensity transcranial ultrasound can enhance the release of neurotrophic factors(e.g.,brain-derived neurotrophic factor),promote autophagy to clear protein aggregates,modulate microglial activation,and temporarily open the blood-brain barrier to facilitate targeted drug delivery.Existing clinical trial data show that low-intensity transcranial ultrasound can reduce amyloid-βplaques,improve motor and cognitive deficits,and promote remyelination in various disease models.Early clinical trials suggest that low-intensity transcranial ultrasound may enhance cognitive scores in Alzheimer’s disease and alleviate motor symptoms in Parkinson’s disease,all while demonstrating a favorable safety profile.Past studies support the notion that by integrating safety,precision,and reversibility,low-intensity transcranial ultrasound can transform the treatment landscape for neurodegenerative disease.However,more advancements are necessary for future clinical application of low-intensity transcranial ultrasound,including optimizing parameters such as frequency,intensity,and duty cycle;considering individual anatomical differences;and confirming long-term efficacy.We believe establishing standardized protocols,conducting larger trials,and investigating the underlying mechanisms to clarify dose-response relationships and refine personalized application strategies are essential in this regard.Future research should focus on translating preclinical findings into clinical practice,addressing technical challenges,and exploring combination therapies with pharmacological or gene interventions.
基金supported by the National Natural Science Foundation of China(Grant Nos.12372187 and 12402228)Fundamental Research Funds for the Central Universities(Grant No.WK2480000010)+3 种基金Fellowship of China Postdoctoral Science Foundation(Grant No.2024M753103)CAS Talent Introduction Program(Grant No.KJ2090007006)Anhui Provincial Natural Science Foundation(Grant No.2408085QA014)National Synchrotron Radiation Laboratory Joint Foundation(Grant Nos.KY2090000097 and KY2090000124).
文摘The stability of the plane grating monochromator in the Hefei Advanced Light Facility is highly important for beamline focusing,with angular vibration being a key indicator for assessing its stability.This paper proposes an elastic fitting method based on fifth-order polynomial fitting for the precise analysis of microangular vibrations on grating surfaces.Compared with the traditional rigid body method,this method fully considers the three major elastic characteristics exhibited by optical components during vibration:significant phase differences,nonuniform deformation gradients,and spatial distribution differences in angular deformation.The research results indicate that this method can accurately reflect the actual vibration state of the grating surface,not only enabling the quantitative prediction of local angular microvibration but also establishing a reliable theoretical analysis framework for the stability assessment of high-precision instruments.
文摘The longitudinal π-extension of carbon nanohoops is one of the most effective bottom-up synthetic strategies toward carbon nanotubes(CNTs).Herein,the precise synthesis of a multi-substituted carbon nanohoop([12]CPP-8PBPy)based on cycloparaphenylenes(CPPs)grafted with eight pyrene-functionalized units was reported.This structurally well-defined nanohoop not only acts as a segment of armchair-type CNTs but also achieves enhanced longitudinal π-extension.The structure of[12]CPP-8PBPy was confirmed by high-resolution mass spectrometry(HRMS)and nuclear magnetic resonance(NMR).The photophysical properties were studied by UV/Vis and photoluminescence spectroscopy.The potential applications of[12]CPP-8PBPy in electron-transport devices were further investigated.
文摘A detailed investigation was carried out to understand how the variations in configurations of the spiroannulated 6-6-6-5-5 pentacyclic diastereoisomers,the key intermediates for the synthesis of two C30 terpene quinonemethides and their stereoisomers,impact the reactivity of cyclopropanation.The configurations at C9,C8,and C14 for all four pentacyclic diastereoisomers involved in the diastereoisomeric mixture were determined through a combination of suitable chemical derivatization and multiple NMR spectroscopic analyses.Based on the defined configuration,the 3D structures of these diastereoisomers were optimized by density functional theory(DFT)calculation.These investigations provide reasonable supports,mainly from the steric considerations,for understanding why different diastereoisomers exhibit markedly different reactivity,as well as regio-and stereo-selectivity for cyclopropanation.In addition,the mechanism for the construction of the spiroannulated 6-6-6-5-5 pentacyclic scaffold via intramolecular Michael/aldol cascade was also investigated by deuterium labeling experiments.
基金Supported by the National Key Research and Development Program of Traditional Chinese Medicine Modernization Project,China(No.2023YFC3504000)the Science and Technology Development Project of Jilin Province,China(No.20240404043ZP)the Science and Technology Innovation Cooperation Project of Changchun Science and Technology Bureau and Chinese Academy of Sciences,China(No.23SH14)。
文摘In this study,a novel polysaccharide GPA-G 2-H was derived from ginseng.Furthermore,the coherent study of its structural characteristics,fermented characteristics in vitro,as well as antioxidant mechanism of fermented product FGPA-G 2-H on Aβ25-35-induced PC 12 cells were explored.The structure of GPA-G 2-H was determined by means of zeta potential analysis,FTIR,HPLC,XRD,GC-MS and NMR.The backbone of GPA-G 2-H was mainly composed of→4)-α-D-Glcp-(1→with branches substituted at O-3.Notably,GPA-G 2-H was degraded by intestinal microbiota in vitro with total sugar content and pH value decreasing,and short-chain fatty acids(SCFAs)increasing.Moreover,GPA-G 2-H significantly promoted the proliferation of Lactobacillus,Muribaculaceae and Weissella,thereby making positive alterations in intestinal microbiota composition.Additionally,FGPA-G 2-H activated the Nrf 2/HO-1 signaling pathway,enhanced HO-1,NQO 1,SOD and GSH-Px,while inhabited Keap 1,MDA and LDH,which alleviated Aβ-induced oxidative stress in PC 12 cells.These provide a solid theoretical basis for the further development of ginseng polysaccharides as functional food and antioxidant drugs.
基金supported by the Natural Science Foundation of Anhui Province of China,No.2208085Y32Scientific Research Plan Project of Anhui Province of China,No.2022AH020076the Chen Xiao-Ping Foundation for the Development of Science and Technology of Hubei Province,No.CXPJJH12000005-07-115(all to CT).
文摘Ischemic stroke represents a significant global health challenge,frequently associated with intricate pathophysiological alterations.During ischemic stroke,the generation of reactive oxygen species markedly increases,leading to direct neuronal damage as well as initiating a cascade of inflammatory responses.This oxidative stress can also disturb the equilibrium of the gut microbiota,resulting in dysbiosis.In turn,an imbalance in gut microbiota can further exacerbate the production of reactive oxygen species and contribute to a pro-inflammatory environment within the body.This creates a vicious cycle that not only promotes the progression of stroke but also leads to adverse functional outcomes.The neuroinflammation and intestinal microbiota dysbiosis that occur following ischemic stroke are critical contributors to stroke progression and adverse functional outcomes.We previously developed manganese-iron Prussian blue nanozymes,characterized by a multi-enzyme structure and a porous design,that exhibit strong antioxidant properties.However,the therapeutic effects of manganese-iron Prussian blue nanozymes on ischemic stroke and their mechanisms of action remain have not been fully elucidated.To investigate this,we constructed a mouse model of middle cerebral artery occlusion and administered manganese-iron Prussian blue nanozymes via gastric gavage.Our results demonstrated that these nanozymes substantially reduced infarct volume,improved neurological function,restored gut microbiota balance,and increased levels of short-chain fatty acids in the mouse model.Treatment of lipopolysaccharide-treated BV-2 cells with short-chain fatty acids markedly decreased the expression levels of components of the Toll-like receptor 4/nuclear factor kappa B signaling pathway,including Toll-like receptor 4,inhibitor of nuclear factor kappa-B kinase subunit alpha,and pp65.These findings suggest that manganese-iron Prussian blue nanozymes can correct gut microbiota dysbiosis and increase short-chain fatty acid production by modulating the Toll-like receptor 4/nuclear factor kappa B signaling pathway,thereby providing therapeutic benefits in the context of ischemic stroke.
基金supported by the National Natural Science Foundation of China(Grant Nos.T2325022,U23A2074,12204462,62275240,62435009,12474494,and 12204468)the Chinese Academy of Sciences(CAS)Project for Young Scientists in Basic Research(Grant No.253 YSBR-049)+3 种基金the Key Research and Development Program of Anhui Province(Grant No.2022b1302007)the China Postdoctoral Science Foundation(Grant No.2024M753083)the National Postdoctoral Program for Innovative Talents(Grant No.BX20240353)the Fundamental Research Funds for the Central Universities(Grant Nos.WK2030000107,WK2030000108,and WK2030000081)。
文摘Programmable two-particle quantum walks are crucial for advancing quantum simulation,computation,and information processing.Although disorder is traditionally associated with information loss,it can also facilitate emergent phenomena such as enhanced energy transport.Here,we experimentally realize a 12-step discrete-time quantum walk in programmable integrated photonic circuits,introducing tunable static and dynamic disorder to explore quantum transport dynamics.In periodic lattices,disorder induces light localization and drives a transition from quantum ballistic to classical diffusive behavior.In particular,quantum walks of correlated photons exhibit a disorder-induced bunching effect,accompanied by enhanced nonclassical correlations.Our platform provides a scalable framework for investigating multiparticle quantum dynamics in engineered environments,promoting the development of quantum optics toward large-scale applications.
基金supported by grants from the National Natural Science Foundation of China(G.F.Wang,grant number 82204071)(P.Y.Su,grant numbers 81874268 and 82473655)the Research Funds of the Center for Big Data and Population Health of IHM(P.Y.Su,No.JKS2023016)Anhui Provincial Health Commission Scientific Research Project(Y.Zhou,No.AHWJ2023A30027)。
文摘Vitamin D deficiency(VDD)represents a significant nutritional concern among children and adolescents.The estimated prevalence of VDD in China is 46.8%in this population^([1]).VDD during childhood and adolescence has been associated with the onset of various conditions,including acute respiratory infections,asthma,atopic dermatitis,and food allergies^([2]).Multiple factors,including age,sun exposure,adiposity,and genetics,influence vitamin D levels^([2,3]).Increasing attention has been directed toward understanding the environmental determinants that may influence vitamin D status.Given the potential of metallic pollutants to disrupt endocrine function and their ubiquity in the environment,investigating the effects of metal exposure on human vitamin D status,particularly in vulnerable populations,is imperative.
基金supported by the National Natural Sci-ence Foundation of China(Nos.22373091,224B2305,and 22573099).
文摘In this work,we develop an extended dissipaton theory that generalizes the environmental couplings beyond the conventional linear and quadratic forms,enabling the treatment of ar-bitrary order of bath couplings.Ap-plying this theoretical framework to the condensed-phase non-Condon spectroscopy,we demonstrate the in-terplay of anharmonicity,non-Con-don and solvent effects on optical spectra,where the higher-order cou-plings arise from the anharmonicity of nuclear potential surface of the excited state.Precise simulations are carried out with high efficiency on linear absorption spectra involving the above mentioned correlated effects.We exhibit how an anharmonic potential modulates the vibronic feature,offering insights into the role of nonlinear environmental couplings in spectroscopic signatures and exemplifying the success of the extended dissipaton formalism as an exact and efficient method for higher-or-der bath couplings.
基金supported by the National Natural Science Foundation of China(32402767)National Key Research and Development Program of China(2022YFD1301102)+3 种基金Anhui Province Natural Science Foundation Youth Project(2308085QC104)AAU Introduction of High-level Talent Funds(RC392107)Key Laboratory of Utilization of Livestock and Forage Resources in Circum-Tarim Region(Co-construction by Ministry and Province),Ministry of Agriculture and Rural Affairs(BSGJSYS202502)the China Agriculture Research System(CARS-38)。
文摘Background Undernutrition disrupts pregnant ewe's metabolic homeostasis and severely inhibits fetal growth and development.In this study,undernourished and nutrition-recovery pregnant sheep models and rumen epithelial cells were utilized to investigate the mechanisms behind undernutrition-induced disruptions in male fetal rumen metabolism and development.Results Maternal undernutrition significantly reduced male fetal rumen weight and papilla length,width and surface area.Maternal undernutrition extremely suppressed nutrient metabolism and energy production in male fetal rumen via JAK3/STAT3 signaling to inhibit cell cycle progression and male fetal rumen development,while maternal nutritional recovery partially restored metabolic inhibition but failed to alleviate male fetal rumen development.Meanwhile,64 differentially expressed miRNAs(DEMs)were identified in male fetal rumen between undernourished ewes and controls.Novel miR-736 was overexpressed both in male fetal rumen of undernourished and nutrition-recovery models.E2F transcription factor 2(E2F2)and MYB proto-oncogene like 2(MYBL2)were the intersection of male fetal rumen differentially expressed genes(DEGs)and DEMs target genes integrated analysis and were predicted as novel miR-736 target genes.Further,we confirmed that novel miR-736 targeted and downregulated E2F2 and MYBL2 expression levels.Silencing E2F2 and MYBL2 promoted apoptosis and inhibited S-phase entry in rumen epithelial cells.Conclusions In summary,maternal undernutrition disrupted male fetal rumen metabolism and elevated novel miR-736,which targeted and downregulated E2F2 and MYBL2 to inhibit cell cycle progression and promote apoptosis,finally inhibited male fetal rumen development.This study provides new insights into the epigenetic mechanisms underlying maternal undernutrition-induced male fetal rumen developmental deficits.
基金Outstanding Youth Scientific Research Project in Anhui Province(2022AH020055)Key Research and Development Projects in Anhui Province(2022i01020016)。
文摘The development of epoxy(EP)nanocomposites has emerged as a prominent research area across diverse sectors,including automotive,construction,and aerospace industries.Recently,adopting biomimetic strategies for the preparation of nanomaterials to design multifunctional epoxy resins has emerged as a prominent research hotspot.Inspired by the growth pattern of coral reefs,this study successfully engineered a novel hierarchical nanostructured material(Fe-NiPS-PBA)with the aim of creating EP nanocomposites that exhibit highly flame-retardant efficiency,exceptional mechanical strength,and distinguished wear-resisting property even at low additive concentrations.With a 3 wt%addition of Fe-NiPS-PBA,the limiting oxygen index of the EP/3Fe-NiPS-PBA nanocomposite increased from 23.5 to 25.9,achieving a UL-94 V-0 rating.Compared to pure EP,EP/3Fe-NiPSPBA nanocomposite reduced the peak heat release rate(PHRR),total heat release(THR),peak smoke production rate(PSPR),total smoke production(TSP),and maximum CO emission(MCO)by 44.1%,66.7%,47.0%,67.8%,and 51.7%,respectively.Moreover,the incorporation of a 1 wt%additive resulted in significant enhancements of tensile strength from 76.7 MPa to 96.9 MPa,while the wear rate demonstrated a remarkable reduction of 77.8%.The Fe-NiPS-PBA significantly enhanced the fire performance and mechanical strength of EP nanocomposites,demonstrating exceptional overall performance in various applications.
基金supported by the National Key Research and Development Program,China(2022YFF1100702,2022YFF1100703)the National Natu-ral Science Foundation of China(32230084,32102104)+1 种基金the Guangdong Provincial Key Research and Development Project(2022B11l1040002)the Anhui Natural Science Foundation(2208085J11).
文摘The integration of accurate detection and immediate bactericidal in a single platform significantly enhances pathogen monitoring and control capabilities,but nanomaterial functional compatibility remains a major challenge.Here,we developed a multifunctional nanoplatform integrating multimode flexible detection and magnetic aggregation-induced sterilization by utilizing the synergistic effect of quinone-phenol grafting nanozymes loaded with Pt single atoms(Pt SA@Q-ACDs)and magnetic carbon dots(Fe_(3)O_(4)@DCDs).In Pt SA@Q-ACDs,Pt SA increased the electron transfer from the quinone-phenol system,and the hydroxyl and pyridine state N defects sequentially synergized to form a double anchor site,the energy barrier for reducing H_(2)O_(2) was reduced,constituting a"1+1>2"bicatalytic system,which improved signal output and sterilization efficiency.Fe_(3)O_(4)@DCD enriches target bacteria through magnetic induction,dramatically reduces background interference,and increases the sterilization efficiency to 100%while realizing the detection of pathogenic bacteria at the single-cell level.Complementing this,we designed an intelligent portable device capable of dynamically switching and interpreting multimodal signals,enabling adaptable field deployment.The multifunctional platform can realize early warning from food processing to the terminal,combined with high bactericidal efficiency,and can implement"closed-loop monitoring"for pathogenic bacteria in an all-round way,which has great potential.
基金financially supported by the National Natural Science Foundation of China(Nos.22175167 and 22375195)the Science Fund for Distinguished Young Scholars of Anhui Province(No.2308085J05)This work was also partially carried out at the Instruments Center for Physical Science,University of Science and Technology of China,and partially performed using the services from Scientific Compass(www.shiyanjia.com).
文摘Nanoscale red phosphorus(NRP)was synthesized via a phosphorus-amine dissolution method and immobilized onto mesoporous silica nanospheres(MSNs)to obtain hybrid NRP@MSN particles with improved dispersion stability.Epoxy resin(EP)composites containing 2 wt%fillers were prepared to evaluate their thermal and flame-retardant behaviors.Compared with EP,the NRP@MSNs/EP composite significantly enhanced fire safety,resulting in a 52.8%reduction in the peak heat release rate,a 13.9%decrease in total smoke production,and a 165%increase in char yield.Mechanical testing revealed a notable toughening effect under impact loading.The improved flame retardancy originates from the combined nano-barrier effect of MSNs and the catalytic charring and radical-quenching functions of NRP.This work demonstrates an efficient strategy for stabilizing NRP and highlights its strong potential as an environmentally friendly flame retardant for EP systems.
基金supported by the National Natural Science Foundation of China(52272177,12204010)the Foundation for the Introduction of High-Level Talents of Anhui University(S020118002/097)+1 种基金the University Synergy Innovation Program of Anhui Province(GXXT-2023-066)the Scientific Research Project of Anhui Provincial Higher Education Institution(2023AH040008)。
文摘Flexible electronics face critical challenges in achieving monolithic three-dimensional(3D)integration,including material compatibility,structural stability,and scalable fabrication methods.Inspired by the tactile sensing mechanism of the human skin,we have developed a flexible monolithic 3D-integrated tactile sensing system based on a holey MXene paste,where each vertical one-body unit simultaneously functions as a microsupercapacitor and pressure sensor.The in-plane mesopores of MXene significantly improve ion accessibility,mitigate the self-stacking of nanosheets,and allow the holey MXene to multifunctionally act as a sensing material,an active electrode,and a conductive interconnect,thus drastically reducing the interface mismatch and enhancing the mechanical robustness.Furthermore,we fabricate a large-scale device using a blade-coating and stamping method,which demonstrates excellent mechanical flexibility,low-power consumption,rapid response,and stable long-term operation.As a proof-of-concept application,we integrate our sensing array into a smart access control system,leveraging deep learning to accurately identify users based on their unique pressing behaviors.This study provides a promising approach for designing highly integrated,intelligent,and flexible electronic systems for advanced human-computer interactions and personalized electronics.
基金supported by the Anhui Provincial Health and Medical Research Project (AHWJ2023A30277)。
文摘Acute eosinophilic pneumonia(AEP) is a pulmonary condition characterized by acute febrile illness and respiratory distress,with bilateral pulmonary infiltrates,particularly eosinophilic infiltration of the lungs.^([1])Amiodarone,a widely applied antiarrhythmic agent,has been reported as a potential cause of drug-induced AEP.^([2]) Most reported cases of amiodarone-induced AEP typically occur following prolonged exposure for two months or more.
基金the National Natural Science Foundation of China (No. 82374301)the State Key Laboratory of Southwestern Chinese Medicine Resources (No. SKLTCM202410)+2 种基金the Key Project of Anhui Province Department of Education (No. 2023AH030070, 2024AH051040)Anhui Province Key Laboratory, China (KFKT202305, KFKT202507, 2024ZYFBAHKLA11, and 2024ZYFBAHKLA15)Greater Health Research Institute of Hefei Comprehensive National Science Center, China (2023CXMMTCM005)。
文摘Chemotherapeutic paclitaxel(PTX) formulations are widely used in clinical cancer treatment;however, they are also associated with concomitant programmed death-ligand(PD-L1) upregulation and an immunosuppressive microenvironment. Herein, we rationally designed carrier-free, reduction-sensitive PTX dimer self-assembling nanoprodrugs(di PC NPs), composed of a glutathione(GSH)-responsive PTX dimer prodrug(di PTX) and the PD-L1 downregulator celastrol(Cel) for combinational chemoimmunotherapy. Following intravenous administration, the di PC NPs exhibited prolonged blood circulation and preferential tumor accumulation by exploiting the enhanced permeability and retention effect. Subsequently, the elevated GSH levels in tumor cells cleaved the disulfide bonds,triggering the rapid release of PTX and Cel. The released PTX elicited potent cytotoxic effects and induced immunogenic cell death(ICD), whereas the released Cel synergistically enhanced ICD and downregulated PD-L1 expression in tumor cells. Together, these effects resulted in remarkable antitumor efficacy with exhibited a favorable safety profile within the therapeutic window in both Lewis lung carcinoma cells and B16F10 tumorbearing mice. Our findings highlight a promising strategy for highly efficient combination chemoimmunotherapy.
基金supported by the National Key Research and Development Program of China(No.2022YFC3704200)the National Natural Science Foundation of China(Nos.42207113,42475148 and U21A2027)the Presidential Foundation of the Hefei Institutes of Physical Science,Chinese Academy Sciences(No.YZJJQY202401).
文摘To maintain air quality during the 31st World University Games,Chengdu employed a range of monitoring and control strategies in 2023.High-resolution regional pollutant distributions were reconstructed by integrating the vertical column densities(VCDs)from mobile MAX-DOAS measurements with Gaussian process regression analysis.The correlation between the spatial distribution derived from MAX-DOAS and that of GEMS and TROPOMI satellite data exceeded 0.6.This paper explores the impact of air quality improvements during the games on the sources of HCHO and the formation process of HONO.During the control period,primary emissions and secondary formations of HCHO contributed 50.85%±24.24%and 42.81%±7.57%to the total atmospheric HCHO,respectively.The study indicates that with improved air quality,HCHO primary emissions decrease while secondary emissions and atmospheric radiation transmission intensities rise.It is found that HONO always appears under the condition of high aerosol optical depth(AOD)and NO_(2),but high NO_(2) concentration and AOD are not necessarily accompanied by high concentrations of HONO.To assess the influence of temperature and humidity on the formation of HONO from NO_(2),we calculated the emission ratesΔHONO∕ΔNO_(2) to quantify the impact of primary sources on total HONO concentrations.The analysis results show that the turning point of relative humidity is 65%(60%–70%)and the turning point of temperature is 31℃(30–32℃).Lower temperatures and higher humidity levels were found to decrease the rate of secondary HONO formation from NO_(2).
