Objective:Patient safety culture is a concern in every healthcare organization,therefore,the healthcare leadership is encountering issues related to patient safety across the globe.In India,there is limited research a...Objective:Patient safety culture is a concern in every healthcare organization,therefore,the healthcare leadership is encountering issues related to patient safety across the globe.In India,there is limited research and information about patient safety culture among healthcare stakeholders and there is relatively little qualitative research available that captures the factors of patient safety culture.Hence,this study aims to explore the perception of healthcare professionals on patient safety culture.Methods:An exploratory qualitative study design was adopted in a tertiary care hospital.Structured focus group discussion(FGD)(n=4)among healthcare professionals and two in-depth interview focus groups were audio-recorded and transcribed.Two coders reviewed transcripts using the editing approach and organized codes into themes.The data were analyzed through MAXQDA 2022(VERBI Software GmbH,Berlin,Germany),qualitative data analysis software,and descriptive analysis technique.The main codes and themes were generated using inductive and deductive method and smart coding was done.Results:Overall,there were 190 unique mentions of codes related to patient safety culture from 4 FGDs.They were categorized into 6 major themes and subcodes were derived via smart coding using the MAXQDA software.“Resources and constraints”was the most prominent code,followed by management support,manpower shortage,burnout,and lack of personnel commitment.Conclusions:The study highlights significant gaps in patient safety culture within the healthcare setting,with resource constraints,management support,and manpower shortages emerging as critical challenges.Burnout and lack of personnel commitment further exacerbate these issues,underscoring the need for targeted interventions.展开更多
Our ability to learn and remember depends on the active formation,remodeling,and elimination of synapses.Thus,the development and growth of synapses as well as their weakening and elimination are essential for neurona...Our ability to learn and remember depends on the active formation,remodeling,and elimination of synapses.Thus,the development and growth of synapses as well as their weakening and elimination are essential for neuronal rewiring.The structural reorganization of synaptic complexes,changes in actin cytos keleton and organelle dynamics,as well as modulation of gene expression,determine synaptic plasticity.It has been proposed that dys regulation of these key synaptic homeostatic processes underlies the synaptic dysfunction observed in many neurodegenerative diseases.Much is known about downstream signaling of activated N-methyl-D-aspartate andα-amino-3-hydroxy-5-methyl-4-isoazolepro pionate receptors;howeve r,other signaling pathways can also contribute to synaptic plasticity and long-lasting changes in learning and memory.The non-receptor tyrosine kinase c-Abl(ABL1)is a key signal transducer of intra and extracellular signals,and it shuttles between the cyto plasm and the nucleus.This review focuses on c-Abl and its synaptic and neuronal functions.Here,we discuss the evidence showing that the activation of c-Abl can be detrimental to neurons,promoting the development of neurodegenerative diseases.Nevertheless,c-Abl activity seems to be in a pivotal balance between healthy synaptic plasticity,regulating dendritic spines remodeling and gene expression after cognitive training,and synaptic dysfunction and loss in neurodegenerative diseases.Thus,c-Abl genetic ablation not only improves learning and memory and modulates the brain genetic program of trained mice,but its absence provides dendritic spines resiliency against damage.Therefo re,the present review has been designed to elu cidate the common links between c-Abl regulation of structural changes that involve the actin cytos keleton and organelles dynamics,and the transc riptional program activated during synaptic plasticity.By summarizing the recent discove ries on c-Abl functions,we aim to provide an overview of how its inhibition co uld be a potentially fruitful treatment to improve degenerative outcomes and delay memory loss.展开更多
In Europe, there are an increasing number of persons suffering from depression, which also affects many relatives. The burden and health when being the relative of an inpatient suffering from severe depression has bee...In Europe, there are an increasing number of persons suffering from depression, which also affects many relatives. The burden and health when being the relative of an inpatient suffering from severe depression has been less examined. The aim of the study was to describe burden, health and sense of coherence among relatives of inpatients with severe depression. Furthermore, the aim was to investigate relatives’ burden in relation to their health and sense of coherence. A cross-sectional design was performed, with a questionnaire consisting of background questions and three instruments;Burden Assessment Scale, General Health Questionnaire and Sense of Coherence scale. The participants consisted of 68 relatives recruited from a sample of inpatients diagnosed with depression in the psychiatric specialist health services in one hospital trust in Norway. The Regional Committee for Medical and Health Research Ethics, Norway South East, gave approval to the study. The relatives reported burden to a various degree, with some reporting a significantly greater burden, poorer health and a weaker sense of coherence than others. With regard to subjective burden eight out of ten relatives reported “Worry about future”, and almost six out of ten were “Upset by change in patient”. Regarding objective burden, more than half the relatives reported having “Less time for friends” and “Reduced leisure time”. In conclusion the relatives with a high level of burden reported more mental distress, poorer health and weaker sense of coherence than those with lower level of burden. Further research should focus on identification of factors predicting burden and health of relatives of inpatients with severe depression.展开更多
Purpose:Wearable devices are commonly used to measure physical activity.However,it remains unclear the effect of wearing these devices on health awareness.Our aim was to provide evidence related to wearing physical ac...Purpose:Wearable devices are commonly used to measure physical activity.However,it remains unclear the effect of wearing these devices on health awareness.Our aim was to provide evidence related to wearing physical activity trackers and health awareness.Methods:A quantitative comparison study design was used comparing participants who wore physical activity tracking devices(n=108)and those who did not(n=112).A paper-based Physical Health Knowledge survey designed for the purpose of this research was used for data collection in 2018.Results:A difference between participants who wore physical activity tracking devices and those that did not was identified in relation to activity levels and physical health awareness.Wearable devices are suggested as an opportunity for nurses to engage people in physical activity with the potential to improve their health awareness.Conclusions:Nurses are well placed in the healthcare landscape to work with patients who own an activity tracker device concerning increasing activity self-monitoring.This information the patient has from the device can also form the basis of health discussions between nurses and the people in their care.展开更多
Objective: The aim of this study was to elucidate the process of professional identity formation and the factors that affect the process in public health nurses (PHNs). Methods: We performed an inductive qualitative a...Objective: The aim of this study was to elucidate the process of professional identity formation and the factors that affect the process in public health nurses (PHNs). Methods: We performed an inductive qualitative analysis based on semi-structured interviews and focus group interviews of 65 PHNs. Results: At years 1 - 5, PHNs did not have a professional self-identity. Therefore, it was important for them to recognize the significance of their own work. At years 6 - 10, PHNs acquired self-assurance as a practitioner through feedback from residents. It was important for them to have a better understanding, broader viewpoints and more affection for their own community. At years 11 - 20, PHNs felt ambivalent toward the challenges and heavy responsibilities based on the objective assessment of their jobs and roles. PHNs felt embarrassed by role changes when they became a manager or an expert. It was important for them to become aware of their new role through managerial education and training. However, some PHNs who were unable to establish a clear PHN identity experienced setbacks at each developmental stage. Conclusions: Our data suggest that a differential approach dependent on the stage and level of confidence in an individual’s PHN identity is required for the formation of PHN identity.展开更多
The objective of this survey was to determine the sexual and reproductive health needs of conservative and/or economically challenged adolescent girls. A total of 310 subjects (16.5 ± 2.2 years old), attending th...The objective of this survey was to determine the sexual and reproductive health needs of conservative and/or economically challenged adolescent girls. A total of 310 subjects (16.5 ± 2.2 years old), attending three private institutes teaching Islamic matter and the holy Quran and two private institutes teaching carpet-weaving in Erzurum, Turkey, were interviewed between November 2004 and February 2005. The ques-tionnaire covered knowledge on reproductive health and sexual matters to attain their feelings prior to their first menarche, their practices during menstruation, and their awareness of gynecological and sexually transmitted dis-eases as well as their attitudes toward and re-sponsiveness to domestic violence. Their re-sponses showed that these issues were con-sidered taboo and/or embarrassing to share. Also, a considerable percentage of the girls had no or limited knowledge on reproductive health and sexual matters and mismanaged gyneco-logical problems and domestic violence. More-over, those had knowledge revealed that their sources were non-scientific information from unprofessional individuals. In conclusion, the conservative and/or economically challenged adolescent girls who are not attending regular high schools need professional lectures on re-productive health and sexual matters.展开更多
Background and aim: People suffering from mental illness and their experiences of attitudes towards them are rarely investigated from the perspective of the individual. The aim was to gain an understanding of how a gr...Background and aim: People suffering from mental illness and their experiences of attitudes towards them are rarely investigated from the perspective of the individual. The aim was to gain an understanding of how a group of mental health patients experienced social relationships in personal settings as well as in society. Method: Open interviews with twenty-five mental health patients were conducted and analysed with a qualitative content analysis. Result: The essence of the result was that mental health patients’ experiences are still not taken enough into account, neither by mental health professionals nor by their social networks. This was underpinned by four core categories: Patients’ experience of deteriorated and reduced social contacts due to various degrees of acceptance and knowledge of people in general;service users reported on difficulties with social contacts in general, with family relationships, relationships with friends and workmates and with employers;reduced life opportunities were expressed, including violated self-image and poor coping competence and, ambivalent experiences of contact with the mental health services were reported. Conclusion and clinical implication: The present study contributes to the understanding of mental health patients’ experiences of professional services and of their social networks. This knowledge may strengthen the implications of patient-centred care essential for the outcome of the care.展开更多
Introduction: Oral health education is an important issue that should be given to children and adolescents, allowing the acquisition of correct oral health behaviors. The objective of this study was to determine the p...Introduction: Oral health education is an important issue that should be given to children and adolescents, allowing the acquisition of correct oral health behaviors. The objective of this study was to determine the prevalence of oral health behaviors among a sample of portuguese adolescents and verify the association with socio-demographic factors, in order to analyze the main needs related with oral health education to improve oral health status among adolescents. Methods: A cross-sectional study was designed with a sample of 447 adolescents aged 12 to 19 years old, attending a public school in Sátão, Portugal. A self-administered questionnaire was applied questioning about socio-demographic factors and oral health behaviors to each adolescent in the classroom. Prevalence was expressed in proportions and crude odds ratio (OR) with 95% confidence intervals (CI) were used to measure the strength of association between oral health behaviors and socio-demographic factors. Results: The prevalence of tooth brushing (twice-a-day or more) was 90.6%. Five point eight percent of adolescents reported daily flossing, more frequent among female gender (female, OR = 2.03, 95% CI = (1.35 to 3.05)) and adolescents older than 15 years (>15 years, OR = 1.90, 95% CI = (1.24 to 2.92)). Sixty-seven percent had at least one dental appointment in the previous twelve months. The prevalence of dental appointments was associated with the father’s professional situation (unemployed, OR = 0.33, 95% CI = (0.17 to 0.65)) and crowding index (>1, OR = 0.4, 95% CI = (0.16 to 0.98)). Thirty-two point nine percent of adolescents referred having at least one episode of dental pain during their lives. Conclusion: Considering the results of the present study that show the need of improvement of some aspects related with oral health among adolescents, oral health community programs and primary preventive strategies, such as improvement of oral health education in schools should be considered in order to reduce the risk level of oral diseases and develop better oral health behaviors.展开更多
This study assessed the knowledge, and perceptions on safety measure practices and challenges of private sector participation (PSP) operators on solid waste management in Lagos State, Nigeria. This was a cross-section...This study assessed the knowledge, and perceptions on safety measure practices and challenges of private sector participation (PSP) operators on solid waste management in Lagos State, Nigeria. This was a cross-sectional study and utilized interviewer administered questionnaire. The study employed purposive sampling among 256 PSP operators. Data were analyzed using descriptive statistics, Pearson’s product moment and multiple regression analysis correlation at 5% level of significance. Respondents’ age was 35.7 ± 4.2 years, and included 78.5% male. About 55.9% of the respondents spent up to 5 years in the waste management operations. Some 44.9% had at least completed secondary school education. A good knowledge of waste management was exhibited by 68.4% of the respondents. The respondents who had spent 16 years and above in waste management operations were more knowledgeable (8.0 ± 2.1) compared to those who had spent lesser time展开更多
The objective of this work is to analyze the reasons why community health interventions in Africa do not consider multisectoral approaches. To achieve it, we perform a mini-review of health development policies and pl...The objective of this work is to analyze the reasons why community health interventions in Africa do not consider multisectoral approaches. To achieve it, we perform a mini-review of health development policies and plans available online in seven countries from four regions of Sub-Saharan Africa. Thus, two main reasons have been highlighted. First, national strategic plans and policies for health development, in their formulation, neither sufficiently emphasize multisectoral approaches, nor sufficiently make these approaches operational in strategies and activities. Second, the mindset of health professionals due to their initial training orientation based on the biomedical approach, stands that disease is only a result of a physiological imbalance in the body;therefore, to restore health, such an imbalance only needs sophisticated procedures and interventions to be overcome. Such an orientation completely ignores the social, cultural and economic context in which the individual lives, which has an irretrievable influence on the health imbalance. However, health, influenced by the conditions in which people are conceived, born, grow, live, work and aged, cannot be effectively improved in a sustainable way without taking into account all these conditions. Whence the importance of approaches based on every sector of human activity that influences the living conditions.展开更多
Exposure to high PM10 by women and children for hours on a daily basis in poor ventilated kitchen may lead to respiratory morbidity among this vulnerable group. In Nigeria, data on the levels of air pollutants associa...Exposure to high PM10 by women and children for hours on a daily basis in poor ventilated kitchen may lead to respiratory morbidity among this vulnerable group. In Nigeria, data on the levels of air pollutants associated with kerosene stove combustion are very scarce. Like-wise little had been documented on the pulmonary health of women exposed to kerosene stove emission. This study was carried out to measure the levels of kerosene combustion emissions within kitchen environments and also assess the pulmonary function status of the exposed women at baseline. Particulate matter (PM10) and gaseous emissions (GE) were measured in six purposively selected clusters of regular kerosene stove users (KSU) using gravimetric sampler and gas monitors, respectively and their values compared with WHO guideline limits. 167 randomly selected KSU were surveyed to elicit their socio demographic features. A spirometer was used to assess the lung function status (FEV1) of 72 KSU in six neighbourhood kitchen clusters. Data were analysed using descriptive statistics, and Pearson’s correlation tests. Respondents’ mean age was 38 + 12.9 years. Mean duration of exposure to GE was 18.9 + 9.8 years. Mean PM10 was 248.1 + 14.1 μg/m3 and ten folds higher than WHO guideline limit of 25 μg/m3. Mean GE in ppm were: CO (0.00), CO2 (200.1 + 12.4), SO2 (0.01 + 0.00) and NO2 (0.00). Mean FEV1 among KSU was 2.0 + 0.5 litres which was significantly lower than the mean predicted value of 2.7 ± 0.5 litres. There was a negative correlation between PM10 and FEV1 (r = -0.7539, p > 0.05). Safer cooking methods and practices to obviate health hazards are advocated.展开更多
Japan’s aging rate (ratio of elderly aged 65 and older to total population) has exceeded 20%. The aim of this study was to clarify the relationships between Health Related Quality of Life, Body Mass Index (BMI), and ...Japan’s aging rate (ratio of elderly aged 65 and older to total population) has exceeded 20%. The aim of this study was to clarify the relationships between Health Related Quality of Life, Body Mass Index (BMI), and sleep quality. Subjects were 51 adults over 55 years old with chronic disease who living in the community. Instruments and structured interviews were used giving due consideration to privacy. Interviews were conducted within 10 - 20 minutes at the out-patient department. The evaluation instruments included bodymass index, Pittsburgh Sleep Quality Index (PSQI), Health Related Quality of Life (HRQOL), and Oral Health Impact Profile (OHIP-14). A significant positive correlation (ρ = 0.321, p < 0.05) between PSQI and QOL (OHIP-14) scores was confirmed with sleep quality being lower with lower QOL scores. A negative correlation (ρ = ?0.339, p < 0.05) between physical health component summary scores (PCS) and mental health component summary scores (MCS) of HRQOL was confirmed, demonstrating that PCS was low, and the level of MCS was high. Sleep quality was found lower among those with lower oral health-related QOL scores. Moreover, in subjects with lower MCS scores, the PCS scores were found to be higher. Accordingly, it was considered appropriate that dental treatment and care, support the maintenance of activities and sleep, and mental health promotion which are likely requisites critical for elderly persons’ maintenance of independent lifestyles in their familiar community.展开更多
Aim: To examine the experiences of health care professional (HCP)-patient interactions in Multiple Sclerosis (MS), identifying factors that can influence these interactions. Methods: A three-stage systematic review an...Aim: To examine the experiences of health care professional (HCP)-patient interactions in Multiple Sclerosis (MS), identifying factors that can influence these interactions. Methods: A three-stage systematic review and thematic synthesis of qualitative and quantitative research was undertaken. Stage 1: the systematic literature search;Stage 2: methodological appraisal of the qualitative papers;Stage 3: thematic synthesis of all qualitative papers and the integration of quantitative findings into the synthesis. Results: Forty-nine qualitative studies were identified. This included 1014 individuals with MS (244 male, 755 female and 15 unknown) and 106 carers and 86 HCPs. Seventeen quantitative studies were identified which included 7680 (2008 male, 5812 females, and 40 unknown) participants as well as 224 carers. Two themes are discussed: 1) The expectations, experiences and perceptions of interactions with HCPs, and 2) The factors that influenced interactions and relationships. Discussion: There is need for improvement in the content and provision of information to patients with MS from HCPs. Specific strategies are suggested and implications for patients and health care providers are considered.展开更多
Countries that have made the health transition from a communicable disease base to a non communicable disease base find themselves gripped in an epidemic of wealth created diseases mediated by altered macronutrient i...Countries that have made the health transition from a communicable disease base to a non communicable disease base find themselves gripped in an epidemic of wealth created diseases mediated by altered macronutrient intakes, energy intakes and reduction in physical activity. Avoiding the negative impact of the nutrition transition while accepting the positive aspects of the wealth transition can best be achieved by focussing on publicising the benefits of a low fat diet in the context of an active lifestyle. How this is achieved should reflect ecologically sound food production appropriate to national needs. Countries that achieve this will be in the best position to capitalize on the reduction in communicable disease rates without causing a rise in non communicable disease rates.展开更多
Objective: The importance of culture in nursing lies in its influence on patients’ health perceptions, behaviors, and responses to care. Despite the challenges posed by the complexity of studying culture, there remai...Objective: The importance of culture in nursing lies in its influence on patients’ health perceptions, behaviors, and responses to care. Despite the challenges posed by the complexity of studying culture, there remains a critical need to develop cultural competence in nursing. This study investigated how nursing students in rural Indonesia enhance their cultural competence through education and practice. Methods: This study employed a qualitative descriptive phenomenological approach. It conducted face-to-face interviews with 32 students across 6 regions, selected purposively. Thematic analysis was employed to evaluate the results. Results: Five themes emerge in this research: perceptions of cultural competence, learning cultural competence in the classroom, practical experience, learning expectations related to cultural competence, and cultural learning barriers. Conclusions: Enhancing cultural competence necessitates enriched curricula, adept clinical mentors, and continual student evaluation. This iterative assessment informs tailored strategies for nurturing cultural proficiency.展开更多
Objective:To evaluate nurses’levels of knowledge and practice regarding preoperative hair removal and prevention of surgical site infection(SSI).Methods:The descriptive and cross-sectional research was conducted betw...Objective:To evaluate nurses’levels of knowledge and practice regarding preoperative hair removal and prevention of surgical site infection(SSI).Methods:The descriptive and cross-sectional research was conducted between February 2023 and May 2023 in a public hospital in northern Turkey with 123 nurses who agreed to participate in the study.Results:The results showed that 64.2%of the nurses thought that preoperative hair removal should be done by shaving with a razor,74%thought that hair removal should be performed the night before the operation,and 70.7%thought that the patient/patient’s relative should perform preoperative hair removal.Conclusions:This study found that nurses’levels of knowledge and practice regarding preoperative hair removal and prevention of SSI were not at the desired level.Following current resources and improving their levels of knowledge and practices are considered to be important for nurses.展开更多
Background:This retrospective cross-sectional study evaluated the antibiogram profile of Gram-negative bacterial infections at Yastebsheron Hospital.The study aimed to identify prevalent pathogens,assess antimicrobial...Background:This retrospective cross-sectional study evaluated the antibiogram profile of Gram-negative bacterial infections at Yastebsheron Hospital.The study aimed to identify prevalent pathogens,assess antimicrobial susceptibility patterns,and develop evidence-based recommendations for empirical antibiotic therapy.Methods:A total of 1,182 clinical specimens(urine,swabs,aspirates,and cerebrospinal fluid)collected in 2022 were analyzed following standard microbiological procedures.Culture and sensitivity testing were performed according to established protocols.Data were analyzed using SPSS version 23 and Microsoft Excel,with results presented through descriptive statistics.Results:Gram-negative bacteria accounted for 48.4%of isolates.Urinary tract infections(UTIs)were the most prevalent,with a significantly higher incidence among female patients(67%).Escherichia coli(59.8%)was the predominant uropathogen.Among the frequently isolated pathogens E.coli(52.5%),Enterobacter spp.(21.9%),Proteus mirabilis(9.8%),and Pseudomonas aeruginosa(8.4%)meropenem demonstrated the highest efficacy.Levofloxacin showed excellent activity against Enterobacter spp.and P.mirabilis(92%susceptibility),while amikacin exhibited moderate effectiveness against E.coli(78%).Morganella morganii displayed the highest multidrug-resistance rates.Colistin was universally effective against P.aeruginosa.Third-generation cephalosporins and nalidixic acid showed limited efficacy against E.coli(21-41%susceptibility).P.mirabilis,Klebsiella pneumoniae,and M.morganii demonstrated low susceptibility to most tested antibiotics.Conclusion:Regular antibiogram updates are essential for monitoring antimicrobial resistance trends and guiding empirical therapy.The study findings support the use of meropenem and levofloxacin as first-line options while highlighting concerning resistance patterns to cephalosporins and quinolones.Local susceptibility data remain crucial for optimizing antibiotic selection and stewardship efforts.展开更多
Objectives This study aimed to determine the current prevalence of nurse retention in Sub-Saharan Africa(SSA),evaluate the strategies and interventions in SSA countries used to retain their nurses,and identify the key...Objectives This study aimed to determine the current prevalence of nurse retention in Sub-Saharan Africa(SSA),evaluate the strategies and interventions in SSA countries used to retain their nurses,and identify the key challenges impeding nurse retention.Methods A systematic review and meta-analysis were conducted.An electronic search was performed in August 2024 across multiple databases,including PubMed,Ovid Medline,Embase,CINAHL,Scopus,and grey literature sources.The studies were screened using Covidence,and quality assessments were conducted using the Mixed Methods Appraisal Tool.Results A total of 31 articles were included in the review.Meta-analysis revealed that the pooled nurses’retention rate in SSA was 53%(95%CI:38%–67%;I2=97%),while the pooled intention to stay(ITS)rate at work was 57%(95%CI:43%–71%;I2=99%).Subgroup analysis by region showed that the ITS rate was highest in East Africa(65%),followed by West Africa(63%),and lowest in Southern Africa(35%).Effective retention strategies included financial and non-financial incentives,increased production and training of nurses,steering students to shortage specialties,adequate rural housing,facility level improvements,availability of career and professional progression opportunities,nurses’recognition and involvement,employment terms,transparency and predictable management of human resources,supportive work environments,leadership,religious factors,and stakeholders’collaborations.Key challenges to nurses’retention include inadequate healthcare funding,governance issues,poor remuneration and working conditions,political interference,high unemployment rates,ineffective mobility management,unregulated international migration,and active recruitment by wealthier nations.Conclusions Nurse retention in SSA remains critically low.Interventions should be formulated for the above-mentioned effective improvement strategies to address these systemic challenges in order to retain nurses in SSA.展开更多
Objective:To evaluate the antioxidant activity of Kaempferia(K.)parviflora rhizome extract and study its protective effect against male reproductive impairment induced by fenitrothion.Methods:The phytochemicals and an...Objective:To evaluate the antioxidant activity of Kaempferia(K.)parviflora rhizome extract and study its protective effect against male reproductive impairment induced by fenitrothion.Methods:The phytochemicals and antioxidant properties of K.parviflora ethanolic extract were assessed.Twenty-four male mice aged 4-weeks-old were assigned into four groups.Groups 1 to 4 respectively received extra virgin olive oil(served as the vehicle control),20 mg/kg body weight(bw)of fenitrothion,50 mg/kg bw of K.parviflora ethanolic extract,and 50 mg/kg bw of K.parviflora ethanolic extract plus 20 mg/kg bw of fenitrothion.Upon completion of 28 days of continuous feeding treatment,the mice were subjected to mating evaluation and the assessment of epididymal sperm quality,lipid peroxidation,testosterone level and histological evaluation.Results:Eight phytochemical compounds were detected in the ethanolic extract of K.parviflora via GC-MS.The extract exhibited a DPPH radical scavenging activity with an EC50 value of(0.870±0.007)mg/mL.Mice fed with fenitrothion in group 2 displayed an increase in relative testis weight,lipid peroxidation levels and a significant reduction in all sperm parameters(sperm concentration,progressive motility,and viability),as well as serum testosterone levels compared to the control mice in group 1(P<0.05).On the other hand,mice fed with K.parviflora ethanolic extract in group 3 showed a significant increase in serum testosterone levels compared to group 1.Mice co-administered with K.parviflora ethanolic extract and fenitrothion in group 4 exhibited a significant improvement in testosterone levels,sperm concentration,motility,and viability compared to the mice administered only with fenitrothion in group 2(P<0.05).Histological analysis of testicular tissue from group 4 further revealed improved testicular morphology in comparison to fenitrothion-treated mice.Conclusions:Eight bioactive compounds were identified in K.parviflora ethanolic extract and the extract exhibited antioxidative properties.Fenitrothion administration impairs testicular function,reducing sperm parameters and testosterone while increasing lipid peroxidation.However,K.parviflora ethanolic extract coadministration alleviates oxidative stress,improves sperm parameters and testosterone levels,and enhances testicular morphology.These findings suggest that K.parviflora ethanolic extract has the therapeutic potential in mitigating male reproductive adverse effects induced by fenitrothion.展开更多
Objective:This study aimed to describe the implementation of advance care planning(ACP)in patients with stroke.Methods:A scoping review was conducted according to the Arksey and O'Malley framework.Accordingly,we s...Objective:This study aimed to describe the implementation of advance care planning(ACP)in patients with stroke.Methods:A scoping review was conducted according to the Arksey and O'Malley framework.Accordingly,we searched for articles published in ScienceDirect,PubMed,Scopus,ProQuest,and Medline.The inclusion criteria were original research on ACP among adult or elderly stroke patients,hospital-or community-based studies,and those published in English or Indonesian.Qualitative analysis was then used to identify keywords,categories,and themes.Results:Among the 1,050 articles identified,only 8 satisfied the inclusion criteria,indicating that limited studies were available for ACP interventions among stroke patients.Four themes were ultimately identified:the strategy implementation of AC,the challenges of ACP implementation,the benefits of ACP,and the factors influencing ACP.Strategy ACP implementation included the ACP method,the communication style,participation role,media used,and ACP documentation.Lack of information about ACP,facilities,incapacitated patients,and reluctance to implement have become challenges to implementation in stroke.The benefits of ACP,particularly the outcomes of the ACP program,included awareness of ACP engagement,patients can express their wishes,and increased advance directive(AD)documentation.The factors influencing ACP included patient condition,knowledge,and appropriate ACP methods.Conclusion:ACP has not been widely used when providing interventions for stroke patients.The implementation of ACP in stroke patients is full of challenges due to various patient conditions.Effective strategies are needed to improve ACP in stroke patients.It is necessary to develop an ACP for stroke patients'method that involves interprofessional collaboration,and studies on AcP in stroke patients need to be further conducted through interprofessional collaboration.展开更多
文摘Objective:Patient safety culture is a concern in every healthcare organization,therefore,the healthcare leadership is encountering issues related to patient safety across the globe.In India,there is limited research and information about patient safety culture among healthcare stakeholders and there is relatively little qualitative research available that captures the factors of patient safety culture.Hence,this study aims to explore the perception of healthcare professionals on patient safety culture.Methods:An exploratory qualitative study design was adopted in a tertiary care hospital.Structured focus group discussion(FGD)(n=4)among healthcare professionals and two in-depth interview focus groups were audio-recorded and transcribed.Two coders reviewed transcripts using the editing approach and organized codes into themes.The data were analyzed through MAXQDA 2022(VERBI Software GmbH,Berlin,Germany),qualitative data analysis software,and descriptive analysis technique.The main codes and themes were generated using inductive and deductive method and smart coding was done.Results:Overall,there were 190 unique mentions of codes related to patient safety culture from 4 FGDs.They were categorized into 6 major themes and subcodes were derived via smart coding using the MAXQDA software.“Resources and constraints”was the most prominent code,followed by management support,manpower shortage,burnout,and lack of personnel commitment.Conclusions:The study highlights significant gaps in patient safety culture within the healthcare setting,with resource constraints,management support,and manpower shortages emerging as critical challenges.Burnout and lack of personnel commitment further exacerbate these issues,underscoring the need for targeted interventions.
基金supported by Comisión Nacional de Investigación Cientifica y Tecnologica-Chile Fondecyt 12011668(to ARA)Fondecyt 1190334(to SZ)+6 种基金Fondecyt 11200592(to MJY)Fondef ID21/10347(to ARA andSZ)Fondef D10E1077(to ARA and SZ)CARE-UCAFB 170005(to ARA)MSCA-RISE-2016-Lysomod-734825 European Union's Horizon 2020Research and Innovation Program under the Marie Sklodowska-Curie grant agreement N°953489(to SZ)Millennium Science Initiative Program-ICN09_016/ICN 2021_045(to ARA)。
文摘Our ability to learn and remember depends on the active formation,remodeling,and elimination of synapses.Thus,the development and growth of synapses as well as their weakening and elimination are essential for neuronal rewiring.The structural reorganization of synaptic complexes,changes in actin cytos keleton and organelle dynamics,as well as modulation of gene expression,determine synaptic plasticity.It has been proposed that dys regulation of these key synaptic homeostatic processes underlies the synaptic dysfunction observed in many neurodegenerative diseases.Much is known about downstream signaling of activated N-methyl-D-aspartate andα-amino-3-hydroxy-5-methyl-4-isoazolepro pionate receptors;howeve r,other signaling pathways can also contribute to synaptic plasticity and long-lasting changes in learning and memory.The non-receptor tyrosine kinase c-Abl(ABL1)is a key signal transducer of intra and extracellular signals,and it shuttles between the cyto plasm and the nucleus.This review focuses on c-Abl and its synaptic and neuronal functions.Here,we discuss the evidence showing that the activation of c-Abl can be detrimental to neurons,promoting the development of neurodegenerative diseases.Nevertheless,c-Abl activity seems to be in a pivotal balance between healthy synaptic plasticity,regulating dendritic spines remodeling and gene expression after cognitive training,and synaptic dysfunction and loss in neurodegenerative diseases.Thus,c-Abl genetic ablation not only improves learning and memory and modulates the brain genetic program of trained mice,but its absence provides dendritic spines resiliency against damage.Therefo re,the present review has been designed to elu cidate the common links between c-Abl regulation of structural changes that involve the actin cytos keleton and organelles dynamics,and the transc riptional program activated during synaptic plasticity.By summarizing the recent discove ries on c-Abl functions,we aim to provide an overview of how its inhibition co uld be a potentially fruitful treatment to improve degenerative outcomes and delay memory loss.
文摘In Europe, there are an increasing number of persons suffering from depression, which also affects many relatives. The burden and health when being the relative of an inpatient suffering from severe depression has been less examined. The aim of the study was to describe burden, health and sense of coherence among relatives of inpatients with severe depression. Furthermore, the aim was to investigate relatives’ burden in relation to their health and sense of coherence. A cross-sectional design was performed, with a questionnaire consisting of background questions and three instruments;Burden Assessment Scale, General Health Questionnaire and Sense of Coherence scale. The participants consisted of 68 relatives recruited from a sample of inpatients diagnosed with depression in the psychiatric specialist health services in one hospital trust in Norway. The Regional Committee for Medical and Health Research Ethics, Norway South East, gave approval to the study. The relatives reported burden to a various degree, with some reporting a significantly greater burden, poorer health and a weaker sense of coherence than others. With regard to subjective burden eight out of ten relatives reported “Worry about future”, and almost six out of ten were “Upset by change in patient”. Regarding objective burden, more than half the relatives reported having “Less time for friends” and “Reduced leisure time”. In conclusion the relatives with a high level of burden reported more mental distress, poorer health and weaker sense of coherence than those with lower level of burden. Further research should focus on identification of factors predicting burden and health of relatives of inpatients with severe depression.
文摘Purpose:Wearable devices are commonly used to measure physical activity.However,it remains unclear the effect of wearing these devices on health awareness.Our aim was to provide evidence related to wearing physical activity trackers and health awareness.Methods:A quantitative comparison study design was used comparing participants who wore physical activity tracking devices(n=108)and those who did not(n=112).A paper-based Physical Health Knowledge survey designed for the purpose of this research was used for data collection in 2018.Results:A difference between participants who wore physical activity tracking devices and those that did not was identified in relation to activity levels and physical health awareness.Wearable devices are suggested as an opportunity for nurses to engage people in physical activity with the potential to improve their health awareness.Conclusions:Nurses are well placed in the healthcare landscape to work with patients who own an activity tracker device concerning increasing activity self-monitoring.This information the patient has from the device can also form the basis of health discussions between nurses and the people in their care.
文摘Objective: The aim of this study was to elucidate the process of professional identity formation and the factors that affect the process in public health nurses (PHNs). Methods: We performed an inductive qualitative analysis based on semi-structured interviews and focus group interviews of 65 PHNs. Results: At years 1 - 5, PHNs did not have a professional self-identity. Therefore, it was important for them to recognize the significance of their own work. At years 6 - 10, PHNs acquired self-assurance as a practitioner through feedback from residents. It was important for them to have a better understanding, broader viewpoints and more affection for their own community. At years 11 - 20, PHNs felt ambivalent toward the challenges and heavy responsibilities based on the objective assessment of their jobs and roles. PHNs felt embarrassed by role changes when they became a manager or an expert. It was important for them to become aware of their new role through managerial education and training. However, some PHNs who were unable to establish a clear PHN identity experienced setbacks at each developmental stage. Conclusions: Our data suggest that a differential approach dependent on the stage and level of confidence in an individual’s PHN identity is required for the formation of PHN identity.
文摘The objective of this survey was to determine the sexual and reproductive health needs of conservative and/or economically challenged adolescent girls. A total of 310 subjects (16.5 ± 2.2 years old), attending three private institutes teaching Islamic matter and the holy Quran and two private institutes teaching carpet-weaving in Erzurum, Turkey, were interviewed between November 2004 and February 2005. The ques-tionnaire covered knowledge on reproductive health and sexual matters to attain their feelings prior to their first menarche, their practices during menstruation, and their awareness of gynecological and sexually transmitted dis-eases as well as their attitudes toward and re-sponsiveness to domestic violence. Their re-sponses showed that these issues were con-sidered taboo and/or embarrassing to share. Also, a considerable percentage of the girls had no or limited knowledge on reproductive health and sexual matters and mismanaged gyneco-logical problems and domestic violence. More-over, those had knowledge revealed that their sources were non-scientific information from unprofessional individuals. In conclusion, the conservative and/or economically challenged adolescent girls who are not attending regular high schools need professional lectures on re-productive health and sexual matters.
文摘Background and aim: People suffering from mental illness and their experiences of attitudes towards them are rarely investigated from the perspective of the individual. The aim was to gain an understanding of how a group of mental health patients experienced social relationships in personal settings as well as in society. Method: Open interviews with twenty-five mental health patients were conducted and analysed with a qualitative content analysis. Result: The essence of the result was that mental health patients’ experiences are still not taken enough into account, neither by mental health professionals nor by their social networks. This was underpinned by four core categories: Patients’ experience of deteriorated and reduced social contacts due to various degrees of acceptance and knowledge of people in general;service users reported on difficulties with social contacts in general, with family relationships, relationships with friends and workmates and with employers;reduced life opportunities were expressed, including violated self-image and poor coping competence and, ambivalent experiences of contact with the mental health services were reported. Conclusion and clinical implication: The present study contributes to the understanding of mental health patients’ experiences of professional services and of their social networks. This knowledge may strengthen the implications of patient-centred care essential for the outcome of the care.
文摘Introduction: Oral health education is an important issue that should be given to children and adolescents, allowing the acquisition of correct oral health behaviors. The objective of this study was to determine the prevalence of oral health behaviors among a sample of portuguese adolescents and verify the association with socio-demographic factors, in order to analyze the main needs related with oral health education to improve oral health status among adolescents. Methods: A cross-sectional study was designed with a sample of 447 adolescents aged 12 to 19 years old, attending a public school in Sátão, Portugal. A self-administered questionnaire was applied questioning about socio-demographic factors and oral health behaviors to each adolescent in the classroom. Prevalence was expressed in proportions and crude odds ratio (OR) with 95% confidence intervals (CI) were used to measure the strength of association between oral health behaviors and socio-demographic factors. Results: The prevalence of tooth brushing (twice-a-day or more) was 90.6%. Five point eight percent of adolescents reported daily flossing, more frequent among female gender (female, OR = 2.03, 95% CI = (1.35 to 3.05)) and adolescents older than 15 years (>15 years, OR = 1.90, 95% CI = (1.24 to 2.92)). Sixty-seven percent had at least one dental appointment in the previous twelve months. The prevalence of dental appointments was associated with the father’s professional situation (unemployed, OR = 0.33, 95% CI = (0.17 to 0.65)) and crowding index (>1, OR = 0.4, 95% CI = (0.16 to 0.98)). Thirty-two point nine percent of adolescents referred having at least one episode of dental pain during their lives. Conclusion: Considering the results of the present study that show the need of improvement of some aspects related with oral health among adolescents, oral health community programs and primary preventive strategies, such as improvement of oral health education in schools should be considered in order to reduce the risk level of oral diseases and develop better oral health behaviors.
文摘This study assessed the knowledge, and perceptions on safety measure practices and challenges of private sector participation (PSP) operators on solid waste management in Lagos State, Nigeria. This was a cross-sectional study and utilized interviewer administered questionnaire. The study employed purposive sampling among 256 PSP operators. Data were analyzed using descriptive statistics, Pearson’s product moment and multiple regression analysis correlation at 5% level of significance. Respondents’ age was 35.7 ± 4.2 years, and included 78.5% male. About 55.9% of the respondents spent up to 5 years in the waste management operations. Some 44.9% had at least completed secondary school education. A good knowledge of waste management was exhibited by 68.4% of the respondents. The respondents who had spent 16 years and above in waste management operations were more knowledgeable (8.0 ± 2.1) compared to those who had spent lesser time
文摘The objective of this work is to analyze the reasons why community health interventions in Africa do not consider multisectoral approaches. To achieve it, we perform a mini-review of health development policies and plans available online in seven countries from four regions of Sub-Saharan Africa. Thus, two main reasons have been highlighted. First, national strategic plans and policies for health development, in their formulation, neither sufficiently emphasize multisectoral approaches, nor sufficiently make these approaches operational in strategies and activities. Second, the mindset of health professionals due to their initial training orientation based on the biomedical approach, stands that disease is only a result of a physiological imbalance in the body;therefore, to restore health, such an imbalance only needs sophisticated procedures and interventions to be overcome. Such an orientation completely ignores the social, cultural and economic context in which the individual lives, which has an irretrievable influence on the health imbalance. However, health, influenced by the conditions in which people are conceived, born, grow, live, work and aged, cannot be effectively improved in a sustainable way without taking into account all these conditions. Whence the importance of approaches based on every sector of human activity that influences the living conditions.
文摘Exposure to high PM10 by women and children for hours on a daily basis in poor ventilated kitchen may lead to respiratory morbidity among this vulnerable group. In Nigeria, data on the levels of air pollutants associated with kerosene stove combustion are very scarce. Like-wise little had been documented on the pulmonary health of women exposed to kerosene stove emission. This study was carried out to measure the levels of kerosene combustion emissions within kitchen environments and also assess the pulmonary function status of the exposed women at baseline. Particulate matter (PM10) and gaseous emissions (GE) were measured in six purposively selected clusters of regular kerosene stove users (KSU) using gravimetric sampler and gas monitors, respectively and their values compared with WHO guideline limits. 167 randomly selected KSU were surveyed to elicit their socio demographic features. A spirometer was used to assess the lung function status (FEV1) of 72 KSU in six neighbourhood kitchen clusters. Data were analysed using descriptive statistics, and Pearson’s correlation tests. Respondents’ mean age was 38 + 12.9 years. Mean duration of exposure to GE was 18.9 + 9.8 years. Mean PM10 was 248.1 + 14.1 μg/m3 and ten folds higher than WHO guideline limit of 25 μg/m3. Mean GE in ppm were: CO (0.00), CO2 (200.1 + 12.4), SO2 (0.01 + 0.00) and NO2 (0.00). Mean FEV1 among KSU was 2.0 + 0.5 litres which was significantly lower than the mean predicted value of 2.7 ± 0.5 litres. There was a negative correlation between PM10 and FEV1 (r = -0.7539, p > 0.05). Safer cooking methods and practices to obviate health hazards are advocated.
文摘Japan’s aging rate (ratio of elderly aged 65 and older to total population) has exceeded 20%. The aim of this study was to clarify the relationships between Health Related Quality of Life, Body Mass Index (BMI), and sleep quality. Subjects were 51 adults over 55 years old with chronic disease who living in the community. Instruments and structured interviews were used giving due consideration to privacy. Interviews were conducted within 10 - 20 minutes at the out-patient department. The evaluation instruments included bodymass index, Pittsburgh Sleep Quality Index (PSQI), Health Related Quality of Life (HRQOL), and Oral Health Impact Profile (OHIP-14). A significant positive correlation (ρ = 0.321, p < 0.05) between PSQI and QOL (OHIP-14) scores was confirmed with sleep quality being lower with lower QOL scores. A negative correlation (ρ = ?0.339, p < 0.05) between physical health component summary scores (PCS) and mental health component summary scores (MCS) of HRQOL was confirmed, demonstrating that PCS was low, and the level of MCS was high. Sleep quality was found lower among those with lower oral health-related QOL scores. Moreover, in subjects with lower MCS scores, the PCS scores were found to be higher. Accordingly, it was considered appropriate that dental treatment and care, support the maintenance of activities and sleep, and mental health promotion which are likely requisites critical for elderly persons’ maintenance of independent lifestyles in their familiar community.
文摘Aim: To examine the experiences of health care professional (HCP)-patient interactions in Multiple Sclerosis (MS), identifying factors that can influence these interactions. Methods: A three-stage systematic review and thematic synthesis of qualitative and quantitative research was undertaken. Stage 1: the systematic literature search;Stage 2: methodological appraisal of the qualitative papers;Stage 3: thematic synthesis of all qualitative papers and the integration of quantitative findings into the synthesis. Results: Forty-nine qualitative studies were identified. This included 1014 individuals with MS (244 male, 755 female and 15 unknown) and 106 carers and 86 HCPs. Seventeen quantitative studies were identified which included 7680 (2008 male, 5812 females, and 40 unknown) participants as well as 224 carers. Two themes are discussed: 1) The expectations, experiences and perceptions of interactions with HCPs, and 2) The factors that influenced interactions and relationships. Discussion: There is need for improvement in the content and provision of information to patients with MS from HCPs. Specific strategies are suggested and implications for patients and health care providers are considered.
文摘Countries that have made the health transition from a communicable disease base to a non communicable disease base find themselves gripped in an epidemic of wealth created diseases mediated by altered macronutrient intakes, energy intakes and reduction in physical activity. Avoiding the negative impact of the nutrition transition while accepting the positive aspects of the wealth transition can best be achieved by focussing on publicising the benefits of a low fat diet in the context of an active lifestyle. How this is achieved should reflect ecologically sound food production appropriate to national needs. Countries that achieve this will be in the best position to capitalize on the reduction in communicable disease rates without causing a rise in non communicable disease rates.
基金supported by an internal grant from Universitas Citra Bangsa(Number 6/VI/LP3M/UCB/22).
文摘Objective: The importance of culture in nursing lies in its influence on patients’ health perceptions, behaviors, and responses to care. Despite the challenges posed by the complexity of studying culture, there remains a critical need to develop cultural competence in nursing. This study investigated how nursing students in rural Indonesia enhance their cultural competence through education and practice. Methods: This study employed a qualitative descriptive phenomenological approach. It conducted face-to-face interviews with 32 students across 6 regions, selected purposively. Thematic analysis was employed to evaluate the results. Results: Five themes emerge in this research: perceptions of cultural competence, learning cultural competence in the classroom, practical experience, learning expectations related to cultural competence, and cultural learning barriers. Conclusions: Enhancing cultural competence necessitates enriched curricula, adept clinical mentors, and continual student evaluation. This iterative assessment informs tailored strategies for nurturing cultural proficiency.
文摘Objective:To evaluate nurses’levels of knowledge and practice regarding preoperative hair removal and prevention of surgical site infection(SSI).Methods:The descriptive and cross-sectional research was conducted between February 2023 and May 2023 in a public hospital in northern Turkey with 123 nurses who agreed to participate in the study.Results:The results showed that 64.2%of the nurses thought that preoperative hair removal should be done by shaving with a razor,74%thought that hair removal should be performed the night before the operation,and 70.7%thought that the patient/patient’s relative should perform preoperative hair removal.Conclusions:This study found that nurses’levels of knowledge and practice regarding preoperative hair removal and prevention of SSI were not at the desired level.Following current resources and improving their levels of knowledge and practices are considered to be important for nurses.
文摘Background:This retrospective cross-sectional study evaluated the antibiogram profile of Gram-negative bacterial infections at Yastebsheron Hospital.The study aimed to identify prevalent pathogens,assess antimicrobial susceptibility patterns,and develop evidence-based recommendations for empirical antibiotic therapy.Methods:A total of 1,182 clinical specimens(urine,swabs,aspirates,and cerebrospinal fluid)collected in 2022 were analyzed following standard microbiological procedures.Culture and sensitivity testing were performed according to established protocols.Data were analyzed using SPSS version 23 and Microsoft Excel,with results presented through descriptive statistics.Results:Gram-negative bacteria accounted for 48.4%of isolates.Urinary tract infections(UTIs)were the most prevalent,with a significantly higher incidence among female patients(67%).Escherichia coli(59.8%)was the predominant uropathogen.Among the frequently isolated pathogens E.coli(52.5%),Enterobacter spp.(21.9%),Proteus mirabilis(9.8%),and Pseudomonas aeruginosa(8.4%)meropenem demonstrated the highest efficacy.Levofloxacin showed excellent activity against Enterobacter spp.and P.mirabilis(92%susceptibility),while amikacin exhibited moderate effectiveness against E.coli(78%).Morganella morganii displayed the highest multidrug-resistance rates.Colistin was universally effective against P.aeruginosa.Third-generation cephalosporins and nalidixic acid showed limited efficacy against E.coli(21-41%susceptibility).P.mirabilis,Klebsiella pneumoniae,and M.morganii demonstrated low susceptibility to most tested antibiotics.Conclusion:Regular antibiogram updates are essential for monitoring antimicrobial resistance trends and guiding empirical therapy.The study findings support the use of meropenem and levofloxacin as first-line options while highlighting concerning resistance patterns to cephalosporins and quinolones.Local susceptibility data remain crucial for optimizing antibiotic selection and stewardship efforts.
文摘Objectives This study aimed to determine the current prevalence of nurse retention in Sub-Saharan Africa(SSA),evaluate the strategies and interventions in SSA countries used to retain their nurses,and identify the key challenges impeding nurse retention.Methods A systematic review and meta-analysis were conducted.An electronic search was performed in August 2024 across multiple databases,including PubMed,Ovid Medline,Embase,CINAHL,Scopus,and grey literature sources.The studies were screened using Covidence,and quality assessments were conducted using the Mixed Methods Appraisal Tool.Results A total of 31 articles were included in the review.Meta-analysis revealed that the pooled nurses’retention rate in SSA was 53%(95%CI:38%–67%;I2=97%),while the pooled intention to stay(ITS)rate at work was 57%(95%CI:43%–71%;I2=99%).Subgroup analysis by region showed that the ITS rate was highest in East Africa(65%),followed by West Africa(63%),and lowest in Southern Africa(35%).Effective retention strategies included financial and non-financial incentives,increased production and training of nurses,steering students to shortage specialties,adequate rural housing,facility level improvements,availability of career and professional progression opportunities,nurses’recognition and involvement,employment terms,transparency and predictable management of human resources,supportive work environments,leadership,religious factors,and stakeholders’collaborations.Key challenges to nurses’retention include inadequate healthcare funding,governance issues,poor remuneration and working conditions,political interference,high unemployment rates,ineffective mobility management,unregulated international migration,and active recruitment by wealthier nations.Conclusions Nurse retention in SSA remains critically low.Interventions should be formulated for the above-mentioned effective improvement strategies to address these systemic challenges in order to retain nurses in SSA.
基金supported by Universiti Tunku Abdul Rahman(UTAR)Research Fund(IPSR/RMC/UTARRF 2021-C2/40).
文摘Objective:To evaluate the antioxidant activity of Kaempferia(K.)parviflora rhizome extract and study its protective effect against male reproductive impairment induced by fenitrothion.Methods:The phytochemicals and antioxidant properties of K.parviflora ethanolic extract were assessed.Twenty-four male mice aged 4-weeks-old were assigned into four groups.Groups 1 to 4 respectively received extra virgin olive oil(served as the vehicle control),20 mg/kg body weight(bw)of fenitrothion,50 mg/kg bw of K.parviflora ethanolic extract,and 50 mg/kg bw of K.parviflora ethanolic extract plus 20 mg/kg bw of fenitrothion.Upon completion of 28 days of continuous feeding treatment,the mice were subjected to mating evaluation and the assessment of epididymal sperm quality,lipid peroxidation,testosterone level and histological evaluation.Results:Eight phytochemical compounds were detected in the ethanolic extract of K.parviflora via GC-MS.The extract exhibited a DPPH radical scavenging activity with an EC50 value of(0.870±0.007)mg/mL.Mice fed with fenitrothion in group 2 displayed an increase in relative testis weight,lipid peroxidation levels and a significant reduction in all sperm parameters(sperm concentration,progressive motility,and viability),as well as serum testosterone levels compared to the control mice in group 1(P<0.05).On the other hand,mice fed with K.parviflora ethanolic extract in group 3 showed a significant increase in serum testosterone levels compared to group 1.Mice co-administered with K.parviflora ethanolic extract and fenitrothion in group 4 exhibited a significant improvement in testosterone levels,sperm concentration,motility,and viability compared to the mice administered only with fenitrothion in group 2(P<0.05).Histological analysis of testicular tissue from group 4 further revealed improved testicular morphology in comparison to fenitrothion-treated mice.Conclusions:Eight bioactive compounds were identified in K.parviflora ethanolic extract and the extract exhibited antioxidative properties.Fenitrothion administration impairs testicular function,reducing sperm parameters and testosterone while increasing lipid peroxidation.However,K.parviflora ethanolic extract coadministration alleviates oxidative stress,improves sperm parameters and testosterone levels,and enhances testicular morphology.These findings suggest that K.parviflora ethanolic extract has the therapeutic potential in mitigating male reproductive adverse effects induced by fenitrothion.
基金funded by the Center for Education Financial Service(Puslapdik)and the Indonesia Endowment Fund for Education(LPDP)(Grant number:02651/J5.2.3/BPI.06/9/2022).
文摘Objective:This study aimed to describe the implementation of advance care planning(ACP)in patients with stroke.Methods:A scoping review was conducted according to the Arksey and O'Malley framework.Accordingly,we searched for articles published in ScienceDirect,PubMed,Scopus,ProQuest,and Medline.The inclusion criteria were original research on ACP among adult or elderly stroke patients,hospital-or community-based studies,and those published in English or Indonesian.Qualitative analysis was then used to identify keywords,categories,and themes.Results:Among the 1,050 articles identified,only 8 satisfied the inclusion criteria,indicating that limited studies were available for ACP interventions among stroke patients.Four themes were ultimately identified:the strategy implementation of AC,the challenges of ACP implementation,the benefits of ACP,and the factors influencing ACP.Strategy ACP implementation included the ACP method,the communication style,participation role,media used,and ACP documentation.Lack of information about ACP,facilities,incapacitated patients,and reluctance to implement have become challenges to implementation in stroke.The benefits of ACP,particularly the outcomes of the ACP program,included awareness of ACP engagement,patients can express their wishes,and increased advance directive(AD)documentation.The factors influencing ACP included patient condition,knowledge,and appropriate ACP methods.Conclusion:ACP has not been widely used when providing interventions for stroke patients.The implementation of ACP in stroke patients is full of challenges due to various patient conditions.Effective strategies are needed to improve ACP in stroke patients.It is necessary to develop an ACP for stroke patients'method that involves interprofessional collaboration,and studies on AcP in stroke patients need to be further conducted through interprofessional collaboration.
