This study aims to enhance the mechanical properties,disintegration,and dissolution rates of crosslinked carrageenan(CRG)capsule shells by shortening the long chains of CRG through a hydrolysis reaction with citric ac...This study aims to enhance the mechanical properties,disintegration,and dissolution rates of crosslinked carrageenan(CRG)capsule shells by shortening the long chains of CRG through a hydrolysis reaction with citric acid(CA).The hydrolysis of CRG was carried out using varying concentrations of CA,resulting in hydrolyzed CRG(HCRG).This was followed by cross-linking with xanthan gum(XG)and the addition of sorbitol(SOR)as a plasticizer.The results indicated that the optimal swelling capacity of HCRG-XG/SOR hard-shell capsules occurred at a CA concentration of 0.5%,achieving a maximum swelling rate of 445.39%after 15 min.Additionally,the best capsule hardness was alsomeasured at this CA concentration,reaching a hardness level of 480.157 g(F=4.67 N).FTIR analysis demonstrated that the presence of the acid group from CA altered the composition of the CRG chains.Furthermore,SEM-EDX mapping analysis revealed that the surface morphology of the synthesized capsules exhibited a relatively smooth texture with a limited number and size of pores,resulting in good capsule stability for drug delivery.Thein vitro disintegration and dissolution rates of theHCRG-XG/SOR capsuleswere observed to be the fastest and highest atpH1.2,respectively.The disintegration time was recorded at 20 min and 46 s,while the dissolution test indicated a drug release of 78.08%after 5min and 100%after 120 min.The drug delivery kinetics ofHCRG-XG/SOR followed the Ritger-Peppas model,indicating a complex release mechanism that involved swelling,diffusion,erosion,and capsule disintegration.展开更多
To review the neuroprotective effects of minocycline in focal cerebral ischemia in animal models.By searching in the databases of PubMed,ScienceDirect,and Scopus,and considering the inclusion and exclusion criteria of...To review the neuroprotective effects of minocycline in focal cerebral ischemia in animal models.By searching in the databases of PubMed,ScienceDirect,and Scopus,and considering the inclusion and exclusion criteria of the study.Studies were included if focal cerebral ischemia model was performed in mammals and including a control group that has been compared with a minocycline group.Written in languages other than English;duplicate data;in vitro studies and combination of minocycline with other neuroprotective agents were excluded.Neurological function of patients was assessed by National Institute of Health Stroke Scale,modified Rankin Scale,and modified Barthel Index.Neuroprotective effects were assessed by detecting the expression of inflammatory cytokines.We examined 35 papers concerning the protective effects of minocycline in focal cerebral ischemia in animal models and 6 clinical trials which had evaluated the neuroprotective effects of minocycline in ischemic stroke.These studies revealed that minocycline increases the viability of neurons and decreases the infarct volume following cerebral ischemia.The mechanisms that were reported in these studies included anti-inflammatory,antioxidant,as well as anti-apoptotic effects.Minocycline also increases the neuronal regeneration following cerebral ischemia.Minocycline has considerable neuroprotective effects against cerebral ischemia-induced neuronal damages.However,larger clinical trials may be required before using minocycline as a neuroprotective drug in ischemic stroke.展开更多
Infant formula provides the largest, if not sole, source of nutrition for an extended interval;the nutritional adequacy of the formula must be confirmed and the indications for its use were well understood. Both iron ...Infant formula provides the largest, if not sole, source of nutrition for an extended interval;the nutritional adequacy of the formula must be confirmed and the indications for its use were well understood. Both iron deficiency and iron excess during the fetal and neonatal period bode poorly for developing organ systems. Voltammetry is analytical method based on current potential measurements in electrochemical cells. In this study the concentration of iron in four brands of powder milk and baby food (based on rice and based on wheat) was analyzed with DPASV and voltammeter device. Total Means ± SE of Iron in baby foods and powder milk (n = 40) were 8.55 ± 1.18 mg/100g, 5.21 ± 0.66 respectively. Iron level in baby food type I and II was lower than labeled value (p p < 0.05).展开更多
The objective of this review is the determination of tyramine in 13 nonalcoholic beers (Maoshaieer) of Tehran market and survey of it’s probably interaction with monoamine oxidase inhibitor drugs (MAOIs) has been inv...The objective of this review is the determination of tyramine in 13 nonalcoholic beers (Maoshaieer) of Tehran market and survey of it’s probably interaction with monoamine oxidase inhibitor drugs (MAOIs) has been investigated. Tyramine was at the highest levels in Baltika (111.34 ± 8.19 μg/ml) and at the lowest level in Bitmalt (8.01 ± 2.09 μg/ml). Comparing different flavors of malt drinks, the highest tyramine content was shown for classic or normal flavor (average 72.99 ± 30.87 μg/ml), while the lowest value belonged to cantaloupe flavored drinks (average 10.55 ± 1.29 μg/ml). In our study, it is seen that there is a significant difference between import and Iranian non-alcoholic beers, the import ones has more tyramine than Iranians. A number of 10 kinds of 13 samples interact whit MAOIs in one serving (250 ml) usage 18.50 mg. The highest tyramine content of Iranian ones is 17.74 mg/250ml and for import ones is 27.83 mg/250ml.展开更多
Global industrialization could be considered as a major cause of environmental contamination with heavy metals. Barley and malt, vastly used in the food industries, are of no exception. Therefore, we aimed to measure ...Global industrialization could be considered as a major cause of environmental contamination with heavy metals. Barley and malt, vastly used in the food industries, are of no exception. Therefore, we aimed to measure the levels of trace elements Zinc, Copper and heavy metals Lead and Cadmium by Differential Pulse Anodic Stripping Voltammetry in 19 barley grain cultivars and their malts in Iran. Ferric reducing antioxidant power (FRAP) assay was also used for determination of antioxidant activity of the samples. The mean levels of Zn, Cd, Pb and Cu were measured to be 18.813 ± 8.575, 0.212 ± 0.116, 0.278 ± 0.163, 3.746 ± 1.118 mg/100g in the barley samples and 14.364 ± 6.391, 0.153 ± 0.098, 0.179 ± 0.082 and 3.033 ± 1.392 mg/100g in the malt samples, respectively. The highest concentration of Zn was measured in the Bahman cultivar of barley and Mb-82-4 sample of malt while the Sahra cultivar of barley and Valfajr sample of malt had the lowest concentration of Pb and the Nimrooz cultivar of barley and Rihane-03 sample of malt had the lowest concentration Cu. The mean levels of zinc and lead in the evaluated samples of barley and the mean levels of zinc, lead and cadmium in the samples of malt were significantly lower than standard limits. Although not significant, the mean levels of cadmium in barley samples and copper in malt samples were higher than the standard limits, but the mean level of copper was found to be significantly higher than the standard limits in the samples of barley (p = 0.008). Antioxidant acitivity was found to be highest in the Mb-82-12 sample of malt and Nik cultivar of barley. The average antioxidant activity was found to be significantly higher in the malt compared to barley grain;1.584 ± 0.596 mg/kg vs. 0.633 ± 0.221 mg/kg (p < 0.001). The mean level of copper in barley samples was significantly higher than the standard limit that needs further investigations to be controlled.展开更多
基金funded through the Penelitian Unggulan Halal,Airlangga University FY 2024 grant number:987/UN3/2024.
文摘This study aims to enhance the mechanical properties,disintegration,and dissolution rates of crosslinked carrageenan(CRG)capsule shells by shortening the long chains of CRG through a hydrolysis reaction with citric acid(CA).The hydrolysis of CRG was carried out using varying concentrations of CA,resulting in hydrolyzed CRG(HCRG).This was followed by cross-linking with xanthan gum(XG)and the addition of sorbitol(SOR)as a plasticizer.The results indicated that the optimal swelling capacity of HCRG-XG/SOR hard-shell capsules occurred at a CA concentration of 0.5%,achieving a maximum swelling rate of 445.39%after 15 min.Additionally,the best capsule hardness was alsomeasured at this CA concentration,reaching a hardness level of 480.157 g(F=4.67 N).FTIR analysis demonstrated that the presence of the acid group from CA altered the composition of the CRG chains.Furthermore,SEM-EDX mapping analysis revealed that the surface morphology of the synthesized capsules exhibited a relatively smooth texture with a limited number and size of pores,resulting in good capsule stability for drug delivery.Thein vitro disintegration and dissolution rates of theHCRG-XG/SOR capsuleswere observed to be the fastest and highest atpH1.2,respectively.The disintegration time was recorded at 20 min and 46 s,while the dissolution test indicated a drug release of 78.08%after 5min and 100%after 120 min.The drug delivery kinetics ofHCRG-XG/SOR followed the Ritger-Peppas model,indicating a complex release mechanism that involved swelling,diffusion,erosion,and capsule disintegration.
文摘To review the neuroprotective effects of minocycline in focal cerebral ischemia in animal models.By searching in the databases of PubMed,ScienceDirect,and Scopus,and considering the inclusion and exclusion criteria of the study.Studies were included if focal cerebral ischemia model was performed in mammals and including a control group that has been compared with a minocycline group.Written in languages other than English;duplicate data;in vitro studies and combination of minocycline with other neuroprotective agents were excluded.Neurological function of patients was assessed by National Institute of Health Stroke Scale,modified Rankin Scale,and modified Barthel Index.Neuroprotective effects were assessed by detecting the expression of inflammatory cytokines.We examined 35 papers concerning the protective effects of minocycline in focal cerebral ischemia in animal models and 6 clinical trials which had evaluated the neuroprotective effects of minocycline in ischemic stroke.These studies revealed that minocycline increases the viability of neurons and decreases the infarct volume following cerebral ischemia.The mechanisms that were reported in these studies included anti-inflammatory,antioxidant,as well as anti-apoptotic effects.Minocycline also increases the neuronal regeneration following cerebral ischemia.Minocycline has considerable neuroprotective effects against cerebral ischemia-induced neuronal damages.However,larger clinical trials may be required before using minocycline as a neuroprotective drug in ischemic stroke.
文摘Infant formula provides the largest, if not sole, source of nutrition for an extended interval;the nutritional adequacy of the formula must be confirmed and the indications for its use were well understood. Both iron deficiency and iron excess during the fetal and neonatal period bode poorly for developing organ systems. Voltammetry is analytical method based on current potential measurements in electrochemical cells. In this study the concentration of iron in four brands of powder milk and baby food (based on rice and based on wheat) was analyzed with DPASV and voltammeter device. Total Means ± SE of Iron in baby foods and powder milk (n = 40) were 8.55 ± 1.18 mg/100g, 5.21 ± 0.66 respectively. Iron level in baby food type I and II was lower than labeled value (p p < 0.05).
文摘The objective of this review is the determination of tyramine in 13 nonalcoholic beers (Maoshaieer) of Tehran market and survey of it’s probably interaction with monoamine oxidase inhibitor drugs (MAOIs) has been investigated. Tyramine was at the highest levels in Baltika (111.34 ± 8.19 μg/ml) and at the lowest level in Bitmalt (8.01 ± 2.09 μg/ml). Comparing different flavors of malt drinks, the highest tyramine content was shown for classic or normal flavor (average 72.99 ± 30.87 μg/ml), while the lowest value belonged to cantaloupe flavored drinks (average 10.55 ± 1.29 μg/ml). In our study, it is seen that there is a significant difference between import and Iranian non-alcoholic beers, the import ones has more tyramine than Iranians. A number of 10 kinds of 13 samples interact whit MAOIs in one serving (250 ml) usage 18.50 mg. The highest tyramine content of Iranian ones is 17.74 mg/250ml and for import ones is 27.83 mg/250ml.
文摘Global industrialization could be considered as a major cause of environmental contamination with heavy metals. Barley and malt, vastly used in the food industries, are of no exception. Therefore, we aimed to measure the levels of trace elements Zinc, Copper and heavy metals Lead and Cadmium by Differential Pulse Anodic Stripping Voltammetry in 19 barley grain cultivars and their malts in Iran. Ferric reducing antioxidant power (FRAP) assay was also used for determination of antioxidant activity of the samples. The mean levels of Zn, Cd, Pb and Cu were measured to be 18.813 ± 8.575, 0.212 ± 0.116, 0.278 ± 0.163, 3.746 ± 1.118 mg/100g in the barley samples and 14.364 ± 6.391, 0.153 ± 0.098, 0.179 ± 0.082 and 3.033 ± 1.392 mg/100g in the malt samples, respectively. The highest concentration of Zn was measured in the Bahman cultivar of barley and Mb-82-4 sample of malt while the Sahra cultivar of barley and Valfajr sample of malt had the lowest concentration of Pb and the Nimrooz cultivar of barley and Rihane-03 sample of malt had the lowest concentration Cu. The mean levels of zinc and lead in the evaluated samples of barley and the mean levels of zinc, lead and cadmium in the samples of malt were significantly lower than standard limits. Although not significant, the mean levels of cadmium in barley samples and copper in malt samples were higher than the standard limits, but the mean level of copper was found to be significantly higher than the standard limits in the samples of barley (p = 0.008). Antioxidant acitivity was found to be highest in the Mb-82-12 sample of malt and Nik cultivar of barley. The average antioxidant activity was found to be significantly higher in the malt compared to barley grain;1.584 ± 0.596 mg/kg vs. 0.633 ± 0.221 mg/kg (p < 0.001). The mean level of copper in barley samples was significantly higher than the standard limit that needs further investigations to be controlled.
