End-stage heart failure has become a major global health challenge.1 The global scarcity of pediatric donor organs results in an insufficient number of annual heart transplantations to meet the clinical demands of chi...End-stage heart failure has become a major global health challenge.1 The global scarcity of pediatric donor organs results in an insufficient number of annual heart transplantations to meet the clinical demands of children with end-stage heart failure.2 While ventricular assist devices(VADs)serve as an effective alternative to heart transplantation,only 448 pediatric VAD implantations were reported in the United States from 2012 to 2021,according to the Pediatric Interagency Registry for Mechanical Circulatory Support(PediMACS).3 Similarly,pediatric VAD utilization in Europe has remained limited over the past two decades.Currently,only first-and second-generation pumps are internationally available for children,with no third-generation,fully magnetically levitated VADs specifically designed for pediatric use.The most commonly used HeartMate III is restricted to older children.4 Notably,China currently lacks dedicated VADs specifically designed for infants and young children.展开更多
基金supported by the National Key R&D Program(2023YFC2706200)the National Natural Science Foundation of China(82470423)Hubei Provincial Natural Science Foundation Projects(JCZRYB202500142).
文摘End-stage heart failure has become a major global health challenge.1 The global scarcity of pediatric donor organs results in an insufficient number of annual heart transplantations to meet the clinical demands of children with end-stage heart failure.2 While ventricular assist devices(VADs)serve as an effective alternative to heart transplantation,only 448 pediatric VAD implantations were reported in the United States from 2012 to 2021,according to the Pediatric Interagency Registry for Mechanical Circulatory Support(PediMACS).3 Similarly,pediatric VAD utilization in Europe has remained limited over the past two decades.Currently,only first-and second-generation pumps are internationally available for children,with no third-generation,fully magnetically levitated VADs specifically designed for pediatric use.The most commonly used HeartMate III is restricted to older children.4 Notably,China currently lacks dedicated VADs specifically designed for infants and young children.
