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面向边缘异构算力的高通量视频分析优化研究
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作者 马丽娜 严龙 +3 位作者 曹华伟 梁彦 叶笑春 范东睿 《高技术通讯》 北大核心 2026年第1期53-66,共14页
大数据时代,视频数据占据了数据流量的82%以上,是名副其实的大数据。如何快速有效地从视频数据中获取价值信息以支持视频驱动的信息服务系统具有十分重要的价值。为了提高视频数据的并发处理能力、降低带宽成本,当前视频分析系统通常部... 大数据时代,视频数据占据了数据流量的82%以上,是名副其实的大数据。如何快速有效地从视频数据中获取价值信息以支持视频驱动的信息服务系统具有十分重要的价值。为了提高视频数据的并发处理能力、降低带宽成本,当前视频分析系统通常部署在靠近数据源头的边缘计算中心,依靠集成异构硬件的边缘计算处理方式来提高处理效果,但相关工作未能充分发挥异构加速芯片的能力。本文针对上述问题,提出了面向异构硬件加速设备的高通量视频分析方法。通过采用解码优化策略和多发射异步执行策略,该方法能够充分利用异构芯片资源,实现了单芯片解码速度提升1.49倍,推理速度提升1.44倍。此外,本文提出的优化策略确保了良好的线性扩展性。在一个由12颗解码芯片和18颗推理芯片组成的有限算力的边缘异构平台上,分别实现了17.71倍解码加速、25.52倍推理加速以及33.22倍的视频内容分析全流程加速效果。 展开更多
关键词 高通量计算 视频处理 边缘计算 异构硬件 解码加速 推理加速
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联合超常规剂量NaCl治疗ACLF伴腹水和SBP临床研究:1例报道 被引量:1
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作者 刘建军 王梦梦 +1 位作者 何国堂 吕广波 《胃肠病学和肝病学杂志》 2025年第4期574-576,共3页
本文报道1例重症酒精性肝炎(alcoholic hepatitis,AH)伴慢加急性肝衰竭(chronic acute liver failure,ACLF)、失代偿性腹水、自发性腹膜炎(spontaneous peritonitis,SBP)、低蛋白血症、电解质紊乱患者联合使用超常规剂量氯化钠(sodium c... 本文报道1例重症酒精性肝炎(alcoholic hepatitis,AH)伴慢加急性肝衰竭(chronic acute liver failure,ACLF)、失代偿性腹水、自发性腹膜炎(spontaneous peritonitis,SBP)、低蛋白血症、电解质紊乱患者联合使用超常规剂量氯化钠(sodium chloride,NaCl)治疗转归。患者除应用人血白蛋白、血浆、糖皮质激素、抗生素、乳果糖、袢利尿剂和螺内酯等治疗外,嘱正常摄入钠盐(6~9 g/d)。另静脉补充平均浓度为2.69%(2.4%~3.5%)和0.9%的NaCl溶液310 mL/d和518.9 mL/d,住院37 d共分别补充11470 mL和19200 mL。收到了纠正低钠血症、增加尿量(2600~4200 mL/d),腹水消失,SBP全愈,改善肝功能与凝血功能,并避免了利尿剂抵抗(diuretic resistance,DR)和血管活性物质抵抗(vasoactive substance resistance,VSR)等,治疗效果显著。 展开更多
关键词 慢加急性肝衰竭 失代偿性腹水 自发性腹膜炎 氯化钠 补钠治疗
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基因6a型丙型病毒性肝炎DAAs治疗失败后再治疗成功1例报道
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作者 王晶 袁琦 廖金卯 《胃肠病学和肝病学杂志》 2025年第4期621-622,共2页
丙型病毒性肝炎是由丙型肝炎病毒(hepatitis C virus,HCV)感染所致的疾病,目前仍是全球常见的感染性疾病之一。基因6型HCV在全球HCV基因型中占比逐年升高,在某些地区已成为主要基因类型,大多数经直接抗病毒药物(direct acting antiviral... 丙型病毒性肝炎是由丙型肝炎病毒(hepatitis C virus,HCV)感染所致的疾病,目前仍是全球常见的感染性疾病之一。基因6型HCV在全球HCV基因型中占比逐年升高,在某些地区已成为主要基因类型,大多数经直接抗病毒药物(direct acting antivirals,DAAs)治疗可治愈,但仍有极小部分治疗失败的病例,本文现报道1例基因6a型丙型病毒性肝炎经2次DAAs治疗失败后使用DAAs联合利巴韦挽救治疗实现持续病毒学应答(sustained virological response,SVR),旨在为本病的治疗方案提供新参考和选择。 展开更多
关键词 慢性丙型肝炎 直接抗病毒药物 治疗失败 再治疗
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县域级基于机器学习的精准招募方法的建立
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作者 傅晓燕 张子涵 +7 位作者 赵芳 周春兰 梁文飚 郁成 严樱枝 斯唯 谭卫斌 薛晖 《中国输血杂志》 2025年第12期1752-1758,共7页
目的建立县域级基于机器学习的献血者精准招募模型,并验证该方法的可推广性与普适性。方法采用回顾性设计,分析苏州市中心血站太仓分站2019—2024年的献血与短信招募数据;综合运用多种机器学习算法,包括极端梯度提升、支持向量机、K近... 目的建立县域级基于机器学习的献血者精准招募模型,并验证该方法的可推广性与普适性。方法采用回顾性设计,分析苏州市中心血站太仓分站2019—2024年的献血与短信招募数据;综合运用多种机器学习算法,包括极端梯度提升、支持向量机、K近邻、逻辑回归、决策树、随机森林及多层感知机,并结合合成少数类过采样、欠采样及代价敏感(MFE、MSFE损失函数)等方法;通过网格搜索调参以筛选性能最佳的模型。结果研究发现,在与常规方法对照的前瞻性研究中,机器学习模型可使高意愿献血者的招募成功率平均提升129.15%,每条短信的平均招募效率较传统方法提高125.02%;在全量短信发送条件下,短信招募率平均提升42.61%,短信发送效率提高31.77%,提高了短信的招募效率。结论本研究为国内首个在县级市层面上开展的基于机器学习的献血者精准招募研究。基于机器学习的精准招募框架不仅能够提升招募效率,降低招募成本,还具有可推广性与普适性,为实现血液供应的安全性与可持续性提供了1种科学且可行的智慧献血路径。 展开更多
关键词 献血者 短信 精准招募 机器学习 人工智能
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基于传统体系结构的CDN内容分发服务性能分析
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作者 马丽娜 张承龙 +3 位作者 曹华伟 梁彦 叶笑春 范东睿 《高技术通讯》 北大核心 2025年第12期1311-1324,共14页
随着移动互联网和物联网的快速发展,越来越多的终端设备接入网络边缘节点,数据量呈现爆炸式增长,其中流媒体数据占比超80%。网络边缘设备需要从数据中心请求数据,导致主干网络流量压力剧增,进而导致数据传输延迟增加,用户服务质量难以... 随着移动互联网和物联网的快速发展,越来越多的终端设备接入网络边缘节点,数据量呈现爆炸式增长,其中流媒体数据占比超80%。网络边缘设备需要从数据中心请求数据,导致主干网络流量压力剧增,进而导致数据传输延迟增加,用户服务质量难以得到有效保障。内容分发网络(content distribution networks,CDN)是缓解主干网络压力、提高服务质量的有效手段。CDN将一定区域内用户经常访问的数据缓存在靠近用户的网络边缘节点,从而减少网络带宽压力,降低数据传输时延,提高服务质量。然而,网络数据内容分发,尤其是流媒体处理,对服务器体系结构性能和功耗有着非常严格的要求,而且网络数据内容分发应用具有不同于传统高性能应用的特征。因此,如何设计高能效CDN服务器体系结构成为亟需解决的问题。基于此,本文对CDN应用在传统服务器体系结构上的性能进行全面的测试,包括应用类型、中央处理器(central processing unit,CPU)利用率、分支预测失误率、缓存(Cache)失效率、网络带宽、时延以及片外存储性能等;基于测试结果,分析了CDN应用对体系结构不同于传统高性能计算应用的需求;基于分析结果,对面向CDN应用的体系结构给出了相应的设计建议和优化方向。本文的研究结果对面向未来高能效的CDN服务器体系结构设计具有一定的借鉴意义和实用价值。 展开更多
关键词 内容分发网络 流媒体 性能特征 架构探索 NGINX
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小肠克罗恩病并发小肠腺癌1例报道
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作者 王馨 陈卫昌 《胃肠病学和肝病学杂志》 2025年第4期623-624,共2页
克罗恩病(Crohn’s disease,CD)是一种免疫介导的胃肠道慢性疾病,小肠腺癌(small bowel adenocarcinoma,SBA)是CD的一种极罕见并发症。CD患者相较健康人群发生SBA的风险显著升高、发病年龄更早、发现更晚、预后更差,多数确诊病例常因术... 克罗恩病(Crohn’s disease,CD)是一种免疫介导的胃肠道慢性疾病,小肠腺癌(small bowel adenocarcinoma,SBA)是CD的一种极罕见并发症。CD患者相较健康人群发生SBA的风险显著升高、发病年龄更早、发现更晚、预后更差,多数确诊病例常因术后病理才能明确诊断。本文报道小肠CD并发SBA病例1例,并进行相关文献回顾。 展开更多
关键词 克罗恩病 小肠腺癌 病例报道
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Cardiovascular implications of metabolic dysfunction-associated fatty liver disease and type 2 diabetes mellitus:A meta-analysis 被引量:1
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作者 Sahana Shetty Renuka Suvarna +2 位作者 Vanessa Ambrose Fistus Shivam Modi Joseph M Pappachan 《World Journal of Hepatology》 2025年第5期198-208,共11页
BACKGROUND Metabolic dysfunction-associated fatty liver disease(MAFLD)and type 2 diabetes mellitus(T2DM)are independent risk factors for the development of cardiovascular disease(CVD)and an exaggerated CVD risk is exp... BACKGROUND Metabolic dysfunction-associated fatty liver disease(MAFLD)and type 2 diabetes mellitus(T2DM)are independent risk factors for the development of cardiovascular disease(CVD)and an exaggerated CVD risk is expected when both diseases co-exist.Therefore,thorough risk stratification is important to inform better clinical practice decisions based on good quality evidence for patient with MAFLD and T2DM.AIM To identify the CVD and cardiovascular event(CVE)risk in a systematic review when MAFLD and T2DM co-exist to inform better clinical practice decisions.METHODS A systematic review was performed by compiling data by searching PubMed,EMBASE and Cochrane Library databases.Quality appraisal of retrieved studies and the meta-analysis were performed using Joanna Briggs Institute(JBI)tool and RevMan 5.4 software respectively.The effect indicators for CVE and CVD risk were expressed as odds ratios(OR)and 95%CI with P-values<0.05 as significant.RESULTS Fourteen(5 cohort and 9 cross-sectional)studies with 370013 participants were included in this review.The metaanalysis of CVE showed that the risk of CVE in T2DM was higher in the MAFLD group when compared to the non-MAFLD group[OR 1.28(95%CI,1.04-1.56)P=0.02]with follow up duration ranging between 5-6 years.The prevalence of CVD in the metanalysis of cross-sectional studies was found to be higher[OR 1.47(95%CI,1.21-1.78)P=0.0001]in T2DM with MAFLD when compared to T2DM without MAFLD.Significant heterogeneity exists due to variations in study design,methodologies,and MAFLD diagnostic criteria,which may have influenced the study's findings.CONCLUSION The presence of MAFLD in T2DM increased the risk of CVE.The prevalence of CVD is higher in T2DM with MAFLD as compared to T2DM without MAFLD.Large well-designed multicentric long-term prospective studies are necessary to appropriately risk stratify the cardiovascular effect of the MAFLD in T2DM patients. 展开更多
关键词 Cardiovascular disease Cardiovascular events Insulin resistance Metabolic dysfunction-associated fatty liver disease Type 2 diabetes mellitus
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Current perspectives and the future of disease-modifying therapies in type 1 diabetes
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作者 Sunetra Mondal Joseph M Pappachan 《World Journal of Diabetes》 SCIE 2025年第1期12-21,共10页
Use of immunomodulating agents to prevent the progression of autoimmuneβ-cell damage leading to type 1 diabetes mellitus(T1DM)is an interesting area for research.These include non-specific anti-inflammatory agents,im... Use of immunomodulating agents to prevent the progression of autoimmuneβ-cell damage leading to type 1 diabetes mellitus(T1DM)is an interesting area for research.These include non-specific anti-inflammatory agents,immunologic vaccination and anti-inflammatory agents targeting specific immune cells or cytokines.Teplizumab is an anti-CD3-molecule that binds to and leads to the disappearance of the CD3/TCR complex and rendering the T cell anergic to its target antigen.Preclinical and clinical trials have demonstrated its efficacy in reducing the decline in serum C-peptide levels and the need for insulin therapy if used early in the disease process of T1DM.The benefits have been apparent as early as six months to as long as seven years after therapy.It has recently been approved by the Food and Drug Administration to delay the onset of clinical(stage 3)type 1 diabetes in children above 8 years of age.In their recent metaanalysis published in the World Journal of Diabetes,Ma et al found that those in the teplizumab treatment group have a greater likelihood of reduction in insulin use,change in C-peptide response,and better glycemic control compared to the control group with a good safety profile.However,all the included randomized control trials have been conducted in high-income countries.High cost of therapy and unknown utility of the molecule in stage 3 disease limit its widespread use. 展开更多
关键词 Teplizumab Type 1 diabetes mellitus Disease modifying therapy β-cell function C-PEPTIDE IMMUNOTHERAPY
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巴赫《第一小提琴独奏奏鸣曲》中的速度、揉弦与和弦分析
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作者 王禹哲 《黄河之声》 2025年第6期71-74,共4页
文章聚焦巴赫《g小调第一小提琴独奏奏鸣曲》(BWV 1001),从速度、揉弦与和弦演奏三方面展开深入分析。这三者在小提琴演奏中彼此密切关联,直接影响音乐表现力与诠释风格。通过比较不同演奏家的录音,文章探讨了演奏速度与和弦处理方法之... 文章聚焦巴赫《g小调第一小提琴独奏奏鸣曲》(BWV 1001),从速度、揉弦与和弦演奏三方面展开深入分析。这三者在小提琴演奏中彼此密切关联,直接影响音乐表现力与诠释风格。通过比较不同演奏家的录音,文章探讨了演奏速度与和弦处理方法之间的相互作用,以及揉弦对音符延展性和情感表达的作用。 展开更多
关键词 小提琴演奏技法 古典音乐 巴赫 巴洛克音乐 多声部音乐
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转棒行为学评价美他多辛对小鼠急性酒精中毒治疗效果
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作者 陈玥 苏丹 +5 位作者 罗峰 张敏 杨棣远 徐钰惟 贵文娟 孙效容 《实验动物科学》 2025年第2期38-43,共6页
目的探讨转棒行为学在小鼠急性酒精中毒模型中的应用价值及美他多辛的治疗作用。方法将30只雄性C57小鼠随机分为3组,分别为正常对照组、模型对照组和美他多辛治疗组(欣立得,0.3 mg/10 g),口服灌胃给药后1 h再灌胃56度二锅头0.15 mL/10 ... 目的探讨转棒行为学在小鼠急性酒精中毒模型中的应用价值及美他多辛的治疗作用。方法将30只雄性C57小鼠随机分为3组,分别为正常对照组、模型对照组和美他多辛治疗组(欣立得,0.3 mg/10 g),口服灌胃给药后1 h再灌胃56度二锅头0.15 mL/10 g。记录小鼠醉酒时间和醒酒时间;酒精灌胃后6 h进行转棒行为学检测,采集小鼠血液,测定血清天冬氨酸转氨酶(AST)、谷丙转氨酶(ALT)、甘油三酯(TG)含量;测定肝乙醇脱氢酶(ADH)活性、超氧化物歧化酶(SOD)活性、丙二醛(MDA)含量、过氧化氢酶(CAT)活性;肝HE染色观察肝组织病理学变化。结果酒精灌胃后,模型对照组醉酒时间短,醒酒时间长,转棒行为学检测在棒时间明显缩短,跌落时转速慢,在棒圈数少,血清AST、ALT、TG明显上升,肝ADH、SOD明显降低,MDA明显增加,与正常对照组相比差异有统计学意义(P<0.01);HE染色提示肝病变呈现区域性特点,可见肝细胞严重变性甚至坏死。与模型对照组相比,美他多辛治疗组小鼠醉酒时间延长,醒酒时间快,转棒行为学检测在棒时间增加,跌落时转速增加,血清AST、ALT、TG明显上升,肝ADH明显增加,MDA明显减少,差异有统计学意义(P<0.05或P<0.01);HE染色提示肝病变呈现区域性特点,肝细胞病变程度较模型对照组明显减轻,且部分肝区域未见明显病变。结论转棒行为学可作为小鼠急性酒精中毒的行为学评价手段,美他多辛对小鼠急性酒精中毒有较好保护作用。 展开更多
关键词 小鼠 急性酒精中毒 肝损伤 转棒行为学 美他多辛
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Strengthening human papillomavirus vaccination programs through multi-country peer learning:lessons from the CHIC initiative
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作者 Christopher Morgan Mary Carol Jennings +8 位作者 Dur-e-Nayab Waheed Nicolas Theopold Anissa Sidibe Ana Bolio Elaine Charurat Felix Ricardo Burdier Emilie Karafillakis Shana Kagan Alex Vorsters 《Cancer Biology & Medicine》 2025年第9期997-1001,共5页
Introduction Human papillomavirus(HPV)vaccination is a cornerstone of cervical cancer prevention,particularly in low-and middle-income countries(LMICs),where the burden of disease remains high~1.The World Health Organ... Introduction Human papillomavirus(HPV)vaccination is a cornerstone of cervical cancer prevention,particularly in low-and middle-income countries(LMICs),where the burden of disease remains high~1.The World Health Organization(WHO)HPV Vaccine Introduction Clearing House reported that 147 countries(of 194 reporting)had fully introduced the HPV vaccine into their national schedules as of 20242.After COVID-19 pandemic disruptions,global coverage is again increasing. 展开更多
关键词 WHO HPV vaccine introduction clearing house multi country peer learning cervical cancer prevention CHIC initiative global coverage human papillomavirus vaccination human papillomavirus hpv vaccination low middle income countries
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A Novel Approach to Enhanced Cancelable Multi-Biometrics Personal Identification Based on Incremental Deep Learning
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作者 Ali Batouche Souham Meshoul +1 位作者 Hadil Shaiba Mohamed Batouche 《Computers, Materials & Continua》 2025年第5期1727-1752,共26页
The field of biometric identification has seen significant advancements over the years,with research focusing on enhancing the accuracy and security of these systems.One of the key developments is the integration of d... The field of biometric identification has seen significant advancements over the years,with research focusing on enhancing the accuracy and security of these systems.One of the key developments is the integration of deep learning techniques in biometric systems.However,despite these advancements,certain challenges persist.One of the most significant challenges is scalability over growing complexity.Traditional methods either require maintaining and securing a growing database,introducing serious security challenges,or relying on retraining the entiremodelwhen new data is introduced-a process that can be computationally expensive and complex.This challenge underscores the need for more efficient methods to scale securely.To this end,we introduce a novel approach that addresses these challenges by integrating multimodal biometrics,cancelable biometrics,and incremental learning techniques.This work is among the first attempts to seamlessly incorporate deep cancelable biometrics with dynamic architectural updates,applied incrementally to the deep learning model as new users are enrolled,achieving high performance with minimal catastrophic forgetting.By leveraging a One-Dimensional Convolutional Neural Network(1D-CNN)architecture combined with a hybrid incremental learning approach,our system achieves high recognition accuracy,averaging 98.98% over incrementing datasets,while ensuring user privacy through cancelable templates generated via a pre-trained CNN model and random projection.The approach demonstrates remarkable adaptability,utilizing the least intrusive biometric traits like facial features and fingerprints,ensuring not only robust performance but also long-term serviceability. 展开更多
关键词 Incremental learning personal identification cancelablemulti-biometrics pattern recognition security deep learning cyber-attacks transfer learning random projection catastrophic forgetting
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Pancreatic neuroendocrine tumors:A case-based evidence review
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作者 Naveena Rikhraj Cornelius J Fernandez +1 位作者 Vanishri Ganakumar Joseph M Pappachan 《World Journal of Gastrointestinal Pathophysiology》 2025年第2期1-11,共11页
Pancreatic neuroendocrine tumors(pNETs)are rare,presenting significant challenges in timely diagnosis and subsequent treatment.The clinical and pathobiological behavior of these tumors varies significantly,making foll... Pancreatic neuroendocrine tumors(pNETs)are rare,presenting significant challenges in timely diagnosis and subsequent treatment.The clinical and pathobiological behavior of these tumors varies significantly,making follow-up and therapeutic approaches challenging for clinicians.Although the majority of these neoplasms are hormonally inactive,some can be associated with endocrine dysfunction.Very rarely,a nonfunctional tumor can later become hormonally active,further complicating prognostication and management.Depending on the character of the disease,clinical picture and prognosis,different treatment modalities are instituted with varying effectivities.We recently came across a unique case of nonfunctioning malignant pNET at an advanced stage,metastatic disease upon diagnosis,managed medically with somatostatin analog therapy(Octreotide)and targeted therapy(Everolimus)with stable disease for 40 months that subsequently turned out to become functional(insulinoma).With the aid of this unique case,we update the current clinical,diagnostic and therapeutic approach to pNETs in this evidence-based review. 展开更多
关键词 Pancreatic neuroendocrine tumour Somatostatin analog therapy INSULINOMA Nonfunctional pNET Metastatic disease Somatostatin receptor imaging
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Renal effects and safety of tirzepatide in subjects with and without diabetes:A systematic review and meta-analysis
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作者 ABM Kamrul-Hasan Shinjan Patra +4 位作者 Deep Dutta Lakshmi Nagendra AFM Muntahi-Reza Sanja Borozan Joseph M Pappachan 《World Journal of Diabetes》 2025年第2期270-283,共14页
BACKGROUND Type 2 diabetes(T2D),as well as obesity,are risk factors for chronic kidney disease(CKD)and end-stage renal disease.The renal impacts of glucose-lowering and weight-lowering drugs and their potential benefi... BACKGROUND Type 2 diabetes(T2D),as well as obesity,are risk factors for chronic kidney disease(CKD)and end-stage renal disease.The renal impacts of glucose-lowering and weight-lowering drugs and their potential benefits in preventing CKD often guide clinicians in choosing them appropriately.Only limited data based on randomized controlled trials(RCTs)is currently available on the renal effects and safety profile of tirzepatide.AIM To explore the renal benefits and safety of tirzepatide vs controls.METHODS RCTs involving patients receiving tirzepatide for any indication in the intervention arm and placebo or active comparator in the control arm were searched through multiple electronic databases.The co-primary outcomes were percent change from baseline(CFB)in urine albumin-to-creatinine ratio(UACR)and absolute CFB in estimated glomerular filtration rate(eGFR;in mL/min/1.73 m^(2));the secondary outcome was tirzepatide’s renal safety profile.RevMan web was used to conduct meta-analysis using random-effects models.Outcomes were presented as mean differences(MD)or risk ratios with 95%confidence intervals.RESULTS Fifteen RCTs(n=14471)with mostly low risk of bias(RoB)were included.Over 26-72 weeks,tirzepatide 10 mg[MD-26.95%(-40.13,-13.76),P<0.0001]and 15 mg[MD-18.03%(-28.58,-7.47),P=0.0008]were superior to placebo in percent reductions of UACR.Tirzepatide,at all doses,outperformed insulin in percent reductions of UACR.Compared to the placebo,the percent UACR reduction was greater in subjects with T2D than those with obesity but without T2D(MD-33.25%vs-7.93%;P=0.001).The CFB in eGFR with all doses of tirzepatide was comparable[5 mg:MD 0.36(-1.41,2.14);10 mg:MD 1.17(-0.22,2.56);15 mg:MD 1.42(-0.04,2.88)];P>0.05 for all vs insulin.Tirzepatide(pooled and separate doses)did not increase the risks of adverse renal events,urinary tract infection,nephrolithiasis,acute kidney injury,and renal cancer compared to the placebo,insulin,and glucagon-like peptide-1 receptor agonists.CONCLUSION Short-term data from RCTs with low RoB suggests that tirzepatide positively impacts UACR without detrimental effects on eGFR in subjects with T2D and obesity without T2D,with a reassuring renal safety profile.Larger RCTs are warranted to prove the longer-term renal benefits of tirzepatide,which might also prevent eGFR decline and worsening of CKD. 展开更多
关键词 Tirzepatide Type 2 diabetes Obesity Urine albumin creatinine ratio Estimated glomerular filtration rate Renal safety Acute kidney injury Chronic kidney disease
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北京冬奥会背景下我国冰雪产业高质量发展的困境与实现路径 被引量:38
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作者 闫静 徐诗枧 《体育文化导刊》 CSSCI 北大核心 2021年第5期78-83,共6页
运用文献资料法等,研究我国冰雪产业高质量发展的机遇与困境,并提出实现路径。北京冬奥会背景下,我国冰雪产业正经历从高速度增长向高质量发展转变,发展机遇:北京冬奥会红利的助力,宏观调控政策引导市场风向,“互联网+”模式激发发展潜... 运用文献资料法等,研究我国冰雪产业高质量发展的机遇与困境,并提出实现路径。北京冬奥会背景下,我国冰雪产业正经历从高速度增长向高质量发展转变,发展机遇:北京冬奥会红利的助力,宏观调控政策引导市场风向,“互联网+”模式激发发展潜能;面临的发展困境:资源供需矛盾凸显,常态化冰雪运动待普及;赛事时空差异显著,高品质冰雪活动待丰富;产品研发中端徘徊,创新型冰雪技术需突破;核心层创造力薄弱,全国性产业融合需升级。提出实现高质量发展的路径:加大政策支持力度指明发展方向,以技术创新为驱动力推动产业转型升级,升级赛事满足消费需求,积极鼓励产业融合等。 展开更多
关键词 体育经济 北京冬奥会 冰雪产业 高质量发展
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肝窦内皮细胞在非酒精性脂肪性肝病发病过程中的作用 被引量:5
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作者 杨婧 高红 +1 位作者 赵耀伟 王锐 《临床肝胆病杂志》 CAS 北大核心 2020年第11期2601-2605,共5页
随着非酒精性脂肪性肝病(NAFLD)在西方发达国家和我国富裕地区的发病率逐年上升,与其相关的治疗手段也在不`断地提高,日益成为人们关注的研究热点。而肝窦内皮细胞(LSEC)作为肝脏的重要生理结构,在NAFLD的发生和发展中发挥着重要的作用... 随着非酒精性脂肪性肝病(NAFLD)在西方发达国家和我国富裕地区的发病率逐年上升,与其相关的治疗手段也在不`断地提高,日益成为人们关注的研究热点。而肝窦内皮细胞(LSEC)作为肝脏的重要生理结构,在NAFLD的发生和发展中发挥着重要的作用。总结了LSEC在NAFLD发病过程中的作用机制,主要包括以下途径:LSEC毛细血管化在单纯性脂肪肝中发生并促进脂肪变性;同时,LSEC有助于非酒精性脂肪性肝炎的氧化应激,并且是非酒精性脂肪性肝炎中肝脏炎症的主要效应物,因此也促进肝纤维化;另外,在NAFLD中,血管生成受到高度刺激并促进NAFLD相关的肝细胞癌发生。然而,LSEC在非酒精性脂肪性肝炎相关性肝硬化中的作用尚未得到具体验证,需要进一步明确,以期为治疗提供新的思路和方向。 展开更多
关键词 非酒精性脂肪性肝病 肝窦内皮细胞 病理过程
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优先愿景下的中国儿童医疗保障双重不平等现状研究 被引量:1
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作者 姚强 焦月芳 +2 位作者 陈山泉 李嘉斌 徐玮泽 《中国卫生政策研究》 CSCD 北大核心 2024年第9期6-13,共8页
目的:分析儿童优先愿景下我国儿童医疗保障水平及其不平等现状。方法:利用中国家庭追踪调查2020年数据,基于全民健康覆盖立方体框架,采用多元回归分析儿童与成人、儿童不同群体之间的医疗保障不平等现状。结果:我国儿童参保率为80.96%,... 目的:分析儿童优先愿景下我国儿童医疗保障水平及其不平等现状。方法:利用中国家庭追踪调查2020年数据,基于全民健康覆盖立方体框架,采用多元回归分析儿童与成人、儿童不同群体之间的医疗保障不平等现状。结果:我国儿童参保率为80.96%,住院和非住院群体医疗费用自付比例分别为64.71%和90.09%。参保率方面,儿童显著低于成人(OR=0.434,P<0.01);上学儿童显著高于未上学儿童(OR=2.075,P<0.01),留守儿童显著低于非留守儿童(OR=0.791,P<0.05)。医疗费用方面,儿童自付比例显著高于成人(β=0.066,P<0.01);6周岁及以上儿童自付医疗费用更低(β<-0.316,P<0.01),家庭收入较高(β<-0.022,P<0.05)、参保(β=-0.033,P<0.01)、住院(β=-0.270,P<0.01)儿童自付比例更低。结论:我国儿童医疗保障呈现双重不平等,即儿童保障水平显著低于成人,0~5周岁、未上学、留守以及低收入家庭儿童保障水平相对较低。建议通过优化儿童缴费标准和推行家庭联保等措施提高儿童参保率。同时,医保政策综合考虑儿童医疗卫生服务需求特点以提高保障水平。此外,重点关注和帮扶儿童医疗保障弱势群体,最终实现医疗保障领域的“儿童优先”。 展开更多
关键词 儿童优先 医疗保障 不平等 中国
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Pheasants in sacred and other forests in western Sichuan: their cultural conservation 被引量:2
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作者 王楠 郑光美 Philip J.K.McGowan 《Chinese Birds》 2012年第1期33-46,共14页
Buddhism and local cultural traditions have long protected wildlife species and their habitats in Tibetan-dominated areas of western Sichuan. In Daocheng County, the White Eared-pheasant (Crossoptilon crossoptilon) ha... Buddhism and local cultural traditions have long protected wildlife species and their habitats in Tibetan-dominated areas of western Sichuan. In Daocheng County, the White Eared-pheasant (Crossoptilon crossoptilon) has been afforded special protection by local people because it is conspicuous and white, a color with special symbolism for Buddhists. This and other cultural reasons have led to pheasants and forests benefiting in some areas. Pheasants were found during surveys between January 2003 and June 2004 in forests with varying degrees of local (non-formal) protection. However, there were significant signs that these traditional attitudes were changing in the face of three particular pressures brought to bear by better roads, improving access to and from the rest of China. The first was the development of a significant local demand for the Chinese caterpillar fungus (Cordyceps sinesis), which is much sought after throughout East Asia and mushrooms. Second, and more recent, is a dramatic increase in tourism from major Chinese cities, bringing non-Tibetan values into Daocheng County and changing the local attitudes to all animals. And then, there is a rise in income of the local population, resulting in a higher timber demand for building big houses, which impact all wildlife in the forest, but local attitudes to sacred forests have been retained so far in spite of this increased timber demand. Lessons should be learnt from the impact that unregulated tourism at Chonggu monastery, the most visited area in the county, has on the surrounding forests so that other sacred and non-sacred forests can best be protected for the long term. The alternative is that several Tibetan Plateau Galliformes, currently considered non-threatened because of their extensive distribution in a remote area, cannot be guaranteed such a healthy future. 展开更多
关键词 cultural conservation Tibetan BUDDHISM wildlife White Eared-pheasant Crossoptilon crossoptilon
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Development of Fuzzy Logic System to Predict the SAW Weldment Shape Profiles
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作者 H. K. Narang M. M. Mahapatra +1 位作者 P K. Jha P. Biswas 《Journal of Marine Science and Application》 2012年第3期387-391,共5页
A fuzzy model was presented to predict the weldment shape profile of submerged arc welds (SAW) including the shape of heat affected zone (HAZ). The SAW bead-on-plates were welded by following a full factorial desi... A fuzzy model was presented to predict the weldment shape profile of submerged arc welds (SAW) including the shape of heat affected zone (HAZ). The SAW bead-on-plates were welded by following a full factorial design matrix. The design matrix consisted of three levels of input welding process parameters. The welds were cross-sectioned and etched, and the zones were measured. A mapping technique was used to measure the various segments of the weld zones. These mapped zones were used to build a fuzzy logic model. The membership functions of the fuzzy model were chosen for the accurate prediction of the weld zone. The fuzzy model was further tested for a set of test case data. The weld zone predicted by the fuzzy logic model was compared with the experimentally obtained shape profiles and close agreement between the two was noted. The mapping technique developed for the weld zones and the fuzzy logiemodel earl be used for on-line control of the SAW process. From the SAW fuzzy logic model an estimation of the fusion and HAZ can also be developed. 展开更多
关键词 submerged arc welding (SAW) fuzzy-logic controller bead height weldment cross-sectional-area heat affected zone (HAZ) fuzzy model fuzzy logic system
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克氏锥虫的新过氧化物酶基因克隆表达研究(英文)
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作者 杨亚明 John Kelly 《中国热带医学》 CAS 2007年第6期876-880,共5页
目的为了探索克氏锥虫的谷胱甘肽依赖的过氧化物酶活性。方法使用基因克隆与表达鉴定的方法学对克氏锥虫谷胱甘肽依赖的过氧化物酶基因克隆和表达。结果一个全新的、18kDa的克氏锥虫单拷贝过氧化物酶基因被完全克隆到E.coli的表达载体pH... 目的为了探索克氏锥虫的谷胱甘肽依赖的过氧化物酶活性。方法使用基因克隆与表达鉴定的方法学对克氏锥虫谷胱甘肽依赖的过氧化物酶基因克隆和表达。结果一个全新的、18kDa的克氏锥虫单拷贝过氧化物酶基因被完全克隆到E.coli的表达载体pHrcHis上,并测序。蛋白序列分析表明与基因库谷胱甘肽依赖的过氧化物酶有高度的同源性。其表达蛋白被纯化分离,测定其酶活性显示了良好的活性,并能被亚油酸-氢过氧化物饱和。结论结果证实克氏锥虫仍然存在过氧化物酶介导的生物代谢。 展开更多
关键词 克氏锥虫 基因克隆 表达 过氧化酶基因
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