Objective: Describe the contribution of Doppler ultrasonography of the cervical and encephalic arteries in the lesion diagnosis of ischemic strokes. Materials and Methods: This was a prospective descriptive and analyt...Objective: Describe the contribution of Doppler ultrasonography of the cervical and encephalic arteries in the lesion diagnosis of ischemic strokes. Materials and Methods: This was a prospective descriptive and analytical study carried out from August 2022 to August 2024 (2 years) in the Doppler ultrasound room in the cardiology departments of Dogta-Lafiè Hospital in Lomé and Kara University Hospital. All patients who underwent Doppler ultrasonography of the cervical and encephalic arteries for ischemic stoke during the study period were included. Results: We selected 110 Doppler ultrasound scans for ischemic stroke. The mean age was 62.1 ± 12.6 years. The M/F sex ratio was 1.4. Cardiovascular risk factors included hypertension (40%), dyslipidemia (42.8%), diabetes (14.5%) and a history of ischemic stroke (09.1%). Doppler ultrasonography was normal in 22 patients, and significant lesions were present in 88 patients (80%). Significant stenoses were found in 60 patients (55%) and occlusions in 28 (25%). These lesions were intracranial (40.9%), extracranial (59.1%), or mixed (19.3%). Significant stenoses and occlusions involved the carotid system in 78.6% and the vertebrobasilar system in 21.4%. In the cervical region, bulbar carotid and post-bulbar stenoses accounted for 61.5%. In the encephalic region, stenoses of the middle and posterior cerebral arteries accounted for 61.1% and 30.5% of lesions respectively. Transcranial Doppler ultrasound revealed 23.9% (21 patients) of intracranial lesions in patients with normal Doppler at the cervical level. Diabetes increases the likelihood of stenosing lesions, while hypertension favours occlusive lesions. Conclusion: arterial lesions in ischemic stroke are intracranial, and extracranial, hence the need to couple transcranial Doppler with Doppler ultrasound of cervical vessels.展开更多
Objectives To investigate the correlation between sex hormones(SH) and aging. Methods Through epidemiological investigation in our country, the levels of SH were measured by radioimmunoassy; lipid profile, glucose and...Objectives To investigate the correlation between sex hormones(SH) and aging. Methods Through epidemiological investigation in our country, the levels of SH were measured by radioimmunoassy; lipid profile, glucose and apolipoprotein by automatic biochemic analytical instrument; T cell subsets by flow cytometer; and MDA, SOD were evaluated by the thiobarbituric acid (TBA) test and the nitrite method modified by Oyanagui respectively using spectrophotometry. Results In men, the serum levels of follicle stimulating hormone ( FSH)、luteinizing hormone(LH) increased significantly with aging, but serum prolactin(PRL) and progesterone(P) levels remained unchanged in all life; Both testosterone (T) and free testosterone (FT) all decreased greatly with aging, but 17β - estradiol( 17β - E_2) was reverse ; E_2 was negatively correlated with T and E_2/T increased with aging. The level of serum total cholesterol (TC) increased with aging, but triglycerides (TG) remain unchanged; compared with young group, high - density lipoprotein cholesterol ( HDL - C) ; HDL - C/TC of other groups decreased significantly, but low - density lipoprotein cholesterol ( LDL - C ) changed inversely; HDL- C/LDL- C reduced slightly with aging and showed no difference between groups. Apolipoprotein A1 (apoA1) and apoB all enhanced greatly with aging; meanwhile the ratio of apoA1/apoB decreased. The concentration of serum glucose (GLU) was unchanged in all life. To compare with those in the young group, CD3 + , CD4 + in other groups reduced greatly, CD4 + remained unchanged. Meanwhile, CD8 + increased significantly with aging. Compared with the young group, serum malondialdehyde(MDA) value of the old ones increased obviously, but the activity of superoxide dismutase(SOD) was reverse. By partial correlation analysis (controlling BMI, FSH, LH and PRL), TC、 LDL-C、apoA1、apoB、CD8 + 、MDA of men all presented a positive correlation with E_2/T respectively, their correlation coefficients (γ) were 0. 262、0. 136、 0. 532、0. 379、0. 394、0. 234 (P < 0. 001 ) ; HDL - C、 HDL- C/TC、HDL- C/LDL- C、CD3 + 、CD4 +/CD8 + 、SOD showed a negatively correlation with E_2/T respectively, γequaled - 0.563、- 0.332、- 0.654、- 0.1530、-0.4140、-0.236(P<0.001). In women, the serum concentrations of FSH、LH increased significantly after menopause; PRL increased little with aging; compared with young group, E_2 and P in postmenopausal groups reduced obviously, E_2/P revealed significant reduce with aging. T enhanced significantly after menopause, but nor did FT. E_2, P and the ratio of E_2/P were negatively correlated with age respectively by bivariate correlation analysis, and a positive relation between T and age. After 70 years old, the level of TC increased obviously, and so did that of TG after menopause; HDL decreased with aging, but LDL increased after 70, with the result that the ratios of HDL- C/TC and HDL- C/LDL- C all reduced with aging; apoA1 decreased gently after 70, but apoB increased signifi- cantly after menopause; correspondingly, the ratio of apoA1/apoB declined obviously. The concentration of GLU increased with aging. CD3 + and CD4 + didn't change until 60, but reduced after 60. Compared with the young groups, CD8 + remained unchanged, CD4 +/CD8 + reduced greatly with aging, CD4 + and CD8 + presented a negatively correlation with age respectively. The value of MDA in serum of women increased notably after 70 years old, but SOD activity already decreased significantly from 60. By partial correlation analysis (controlling BMI, FSH, LH and PRL), HDL-C、CD4 +、CD4 +/CD8 + showed a certain correlation with E_2/P respectively; γ were 0. 245、 0.157、0. 154 ( P <0.05 ) ; TG、 LDL、 apoB、 apoA1/ apoB、SOD presented a negatively correlation with E_2/P respectively, γ were 0. 452、 0. 236、 0.321、 0. 135、 0.156、0.154、0.426 ( P < 0.05 ). Conclusions The Disequilibrium of SH had correlations with lipid profile, cellular immunological function and lipid peroxides and oxidation system; these suggested SH took an important role in the process of aging.展开更多
文摘Objective: Describe the contribution of Doppler ultrasonography of the cervical and encephalic arteries in the lesion diagnosis of ischemic strokes. Materials and Methods: This was a prospective descriptive and analytical study carried out from August 2022 to August 2024 (2 years) in the Doppler ultrasound room in the cardiology departments of Dogta-Lafiè Hospital in Lomé and Kara University Hospital. All patients who underwent Doppler ultrasonography of the cervical and encephalic arteries for ischemic stoke during the study period were included. Results: We selected 110 Doppler ultrasound scans for ischemic stroke. The mean age was 62.1 ± 12.6 years. The M/F sex ratio was 1.4. Cardiovascular risk factors included hypertension (40%), dyslipidemia (42.8%), diabetes (14.5%) and a history of ischemic stroke (09.1%). Doppler ultrasonography was normal in 22 patients, and significant lesions were present in 88 patients (80%). Significant stenoses were found in 60 patients (55%) and occlusions in 28 (25%). These lesions were intracranial (40.9%), extracranial (59.1%), or mixed (19.3%). Significant stenoses and occlusions involved the carotid system in 78.6% and the vertebrobasilar system in 21.4%. In the cervical region, bulbar carotid and post-bulbar stenoses accounted for 61.5%. In the encephalic region, stenoses of the middle and posterior cerebral arteries accounted for 61.1% and 30.5% of lesions respectively. Transcranial Doppler ultrasound revealed 23.9% (21 patients) of intracranial lesions in patients with normal Doppler at the cervical level. Diabetes increases the likelihood of stenosing lesions, while hypertension favours occlusive lesions. Conclusion: arterial lesions in ischemic stroke are intracranial, and extracranial, hence the need to couple transcranial Doppler with Doppler ultrasound of cervical vessels.
文摘Objectives To investigate the correlation between sex hormones(SH) and aging. Methods Through epidemiological investigation in our country, the levels of SH were measured by radioimmunoassy; lipid profile, glucose and apolipoprotein by automatic biochemic analytical instrument; T cell subsets by flow cytometer; and MDA, SOD were evaluated by the thiobarbituric acid (TBA) test and the nitrite method modified by Oyanagui respectively using spectrophotometry. Results In men, the serum levels of follicle stimulating hormone ( FSH)、luteinizing hormone(LH) increased significantly with aging, but serum prolactin(PRL) and progesterone(P) levels remained unchanged in all life; Both testosterone (T) and free testosterone (FT) all decreased greatly with aging, but 17β - estradiol( 17β - E_2) was reverse ; E_2 was negatively correlated with T and E_2/T increased with aging. The level of serum total cholesterol (TC) increased with aging, but triglycerides (TG) remain unchanged; compared with young group, high - density lipoprotein cholesterol ( HDL - C) ; HDL - C/TC of other groups decreased significantly, but low - density lipoprotein cholesterol ( LDL - C ) changed inversely; HDL- C/LDL- C reduced slightly with aging and showed no difference between groups. Apolipoprotein A1 (apoA1) and apoB all enhanced greatly with aging; meanwhile the ratio of apoA1/apoB decreased. The concentration of serum glucose (GLU) was unchanged in all life. To compare with those in the young group, CD3 + , CD4 + in other groups reduced greatly, CD4 + remained unchanged. Meanwhile, CD8 + increased significantly with aging. Compared with the young group, serum malondialdehyde(MDA) value of the old ones increased obviously, but the activity of superoxide dismutase(SOD) was reverse. By partial correlation analysis (controlling BMI, FSH, LH and PRL), TC、 LDL-C、apoA1、apoB、CD8 + 、MDA of men all presented a positive correlation with E_2/T respectively, their correlation coefficients (γ) were 0. 262、0. 136、 0. 532、0. 379、0. 394、0. 234 (P < 0. 001 ) ; HDL - C、 HDL- C/TC、HDL- C/LDL- C、CD3 + 、CD4 +/CD8 + 、SOD showed a negatively correlation with E_2/T respectively, γequaled - 0.563、- 0.332、- 0.654、- 0.1530、-0.4140、-0.236(P<0.001). In women, the serum concentrations of FSH、LH increased significantly after menopause; PRL increased little with aging; compared with young group, E_2 and P in postmenopausal groups reduced obviously, E_2/P revealed significant reduce with aging. T enhanced significantly after menopause, but nor did FT. E_2, P and the ratio of E_2/P were negatively correlated with age respectively by bivariate correlation analysis, and a positive relation between T and age. After 70 years old, the level of TC increased obviously, and so did that of TG after menopause; HDL decreased with aging, but LDL increased after 70, with the result that the ratios of HDL- C/TC and HDL- C/LDL- C all reduced with aging; apoA1 decreased gently after 70, but apoB increased signifi- cantly after menopause; correspondingly, the ratio of apoA1/apoB declined obviously. The concentration of GLU increased with aging. CD3 + and CD4 + didn't change until 60, but reduced after 60. Compared with the young groups, CD8 + remained unchanged, CD4 +/CD8 + reduced greatly with aging, CD4 + and CD8 + presented a negatively correlation with age respectively. The value of MDA in serum of women increased notably after 70 years old, but SOD activity already decreased significantly from 60. By partial correlation analysis (controlling BMI, FSH, LH and PRL), HDL-C、CD4 +、CD4 +/CD8 + showed a certain correlation with E_2/P respectively; γ were 0. 245、 0.157、0. 154 ( P <0.05 ) ; TG、 LDL、 apoB、 apoA1/ apoB、SOD presented a negatively correlation with E_2/P respectively, γ were 0. 452、 0. 236、 0.321、 0. 135、 0.156、0.154、0.426 ( P < 0.05 ). Conclusions The Disequilibrium of SH had correlations with lipid profile, cellular immunological function and lipid peroxides and oxidation system; these suggested SH took an important role in the process of aging.
