Micro/nanorobots have exhibited excellent application potential in the biomedical field,such as drug delivery,minimally invasive surgery,and bio-sensing.Furthermore,in order to achieve practical application,it is esse...Micro/nanorobots have exhibited excellent application potential in the biomedical field,such as drug delivery,minimally invasive surgery,and bio-sensing.Furthermore,in order to achieve practical application,it is essential for swimming micro/nanorobots to navigate towards specific targets or adjust their speed and morphology in complete environments.The navigation of swimming micro/nanorobots with temporal and spatial precision is critical for fulfilling the demand of applications.Here,we introduced a fully integrated wearable control system for micro/nanorobots navigation and manipulation,which is composed of a multifunctional sensor array,an artificial intelligence(AI)planner,and a magnetic field generator.The sensor array could perceive real-time changes in gestures,wrist rotation,and acoustic signals.AI planner based on machine learning offers adaptive path planning in response to dynamically changing signals to generate magnetic fields for the on-demand manipulation of micro/nanorobots.Such a novel,feasible control strategy was validated in the biological experiment in which cancer cells were targeted and killed by photothermal therapy using micro/nanorobots and integrated control platform.This wearable control system could play a crucial role in future intelligent medical applications and could be easily reconfigured toward other medical robots’control.展开更多
Per-and polyfluorinated alkyl substances(PFASs) are commonly used in industrial processes and daily life products.Because they are persistent, they accumulate in the environment, wildlife and humans.Although many stud...Per-and polyfluorinated alkyl substances(PFASs) are commonly used in industrial processes and daily life products.Because they are persistent, they accumulate in the environment, wildlife and humans.Although many studies have focused on two of the most representative PFASs, PFOS and PFOA, the potential toxicity of short-chain PFASs has not yet been given sufficient attention.We used a battery of assays to evaluate the toxicity of several four-carbon and six-carbon perfluorinated sulfonates and carboxyl acids(PFBS,PFHxS, PFBA and PFHxA), with a human mesenchymal stem cell(hMSC) system.Our results demonstrate significant cyto-and potential developmental toxicity for all the compounds analyzed, with shared but also distinct mechanisms of toxicity.Moreover, the effects of PFBS and PFHxS were stronger than those of PFBA and PFHxA, but occurred at higher doses compared to PFOS or PFOA.展开更多
How a mammalian fertilized egg acquires totipotency and develops into a full-term offspring is a fundamental scientific question.Human embryonic development is difficult to study due to limited resources,technical cha...How a mammalian fertilized egg acquires totipotency and develops into a full-term offspring is a fundamental scientific question.Human embryonic development is difficult to study due to limited resources,technical challenges and ethics.Moreover,the precise regulatory mechanism underlying early human embryonic development remains unknown.In recent years,the emergence of stem cell-based embryo models(SCBEM)provides the opportunity to reconstitute pre-to post-implantation development in vitro.These models to some extent mimic the embryo morphologically and transcriptionally,and thus may be used to study key events in mammalian pre-and post-implantation development.Many groups have successfully generated SCBEM of the mouse and human.Here,we provide a comparative review of the mouse and human SCBEM,discuss the capability of these models to mimic natural embryos and give a perspective on their potential future applications.展开更多
Hepatitis C virus (HCV) has emerged as a leading cause of hepatocellular carcinoma (HCC). In most cases, the virus causes HCC in the presence of chronic hepatic inflammation, advanced fibrosis, and cirrhosis. A combin...Hepatitis C virus (HCV) has emerged as a leading cause of hepatocellular carcinoma (HCC). In most cases, the virus causes HCC in the presence of chronic hepatic inflammation, advanced fibrosis, and cirrhosis. A combination of viral, environmental, and genetic factors are likely to determine the host immune response to the infection as well as the progression to HCC. Clinical and epidemiologic studies have identified many of the risk factors associated with HCC development in patients with chronic hepatitis C. Male sex and older age are considered as independent risk factors for HCC, while alcohol consumption accelerates fibrosis, increasing the risk for progression to HCC. Obesity, diabetes mellitus, nonalcoholic fatty liver disease, aflatoxin exposure and occult hepatitis B infection, all contribute to a higher HCC risk. HCV patients infected with HCV genotype 3 are also more likely to develop HCC and genetic variations such as single nucleotide polymorphisms, which may also alter the risk. Sustained virological response to the antiviral therapy results in significantly more favorable long-term outcomes. The incidence of HCC after HCV eradication is similar between patients treated with peginterferon plus ribavirin and direct-acting antiviral therapy.展开更多
Walking on the water surface is an effective method for miniature robots to transport payloads with dramatically decreased interfacial drag. Current aquatic robots reported are generally actuated by a beam of focused ...Walking on the water surface is an effective method for miniature robots to transport payloads with dramatically decreased interfacial drag. Current aquatic robots reported are generally actuated by a beam of focused light that can trigger asymmetrical deformation, enabling the directional movement through horizontal momentum transfer of photoinduced actuation force to the water. However, the operations are heavily dependent on manual manipulation of the focused light, making the long-term actuation and application of the aquatic robots in vast scenarios challenging. Herein, we developed a kind of water striderinspired robot that can autonomously manage the motion on the water surface under solar irradiation, with their direction steerable by a magnetic field. The motion of this bioinspired robot on the water surface was achieved by the use of a solar cell panel as a driving module to enable propulsive motion based on the conversion of light-electric-mechanical energies. The superhydrophobic design of its leg surfaces enables the aquatic robots with weight-bearing and drag-reducing abilities. With the assistance of magnetic navigation, the bioinspired robot can continuously and controllably locomote to the oily spill floating on the water body and collect them with high efficiency. For further demonstration, the treatment of oil spills in a campus pool with high efficiency has also been achieved. This on-site oil-spill treating strategy, taking advantage of a home-made bioinspired robot actuated by natural sunlight under magnetic steering, shows great potential applications in water-body remediation.展开更多
基金supported by the National Key Research and Development Program(2022YFB4701700)National Excellent Youth Science Fund Project of the National Natural Science Foundation of China(52322502)+6 种基金the National Outstanding Youth Science Fund Project of National Natural Science Foundation of China(52025054)National Natural Science Foundation of China(52175009),Postdoctoral Fellowship Program of CPSF(GZC20232498)Postdoctoral Innovative Talents in Shandong Province(SDBX2023011)China Postdoctoral Science Foundation Grant(2023M733341)Key R&D Program of Shandong Province,China(2021ZLGX04)National Heilongjiang Providence Nature Science Foundation of China(YQ2022E022)Fundamental Research Funds for the Central Universities。
文摘Micro/nanorobots have exhibited excellent application potential in the biomedical field,such as drug delivery,minimally invasive surgery,and bio-sensing.Furthermore,in order to achieve practical application,it is essential for swimming micro/nanorobots to navigate towards specific targets or adjust their speed and morphology in complete environments.The navigation of swimming micro/nanorobots with temporal and spatial precision is critical for fulfilling the demand of applications.Here,we introduced a fully integrated wearable control system for micro/nanorobots navigation and manipulation,which is composed of a multifunctional sensor array,an artificial intelligence(AI)planner,and a magnetic field generator.The sensor array could perceive real-time changes in gestures,wrist rotation,and acoustic signals.AI planner based on machine learning offers adaptive path planning in response to dynamically changing signals to generate magnetic fields for the on-demand manipulation of micro/nanorobots.Such a novel,feasible control strategy was validated in the biological experiment in which cancer cells were targeted and killed by photothermal therapy using micro/nanorobots and integrated control platform.This wearable control system could play a crucial role in future intelligent medical applications and could be easily reconfigured toward other medical robots’control.
基金supported by the National Natural Science Foundation of China (Nos.21876197, 21577166, 21707160)the Chinese Academy of Sciences (Nos.XDB14040301, 29[2015]30, QYZDJ-SSW-DQC017)the K.C.Wong Education Foundation.
文摘Per-and polyfluorinated alkyl substances(PFASs) are commonly used in industrial processes and daily life products.Because they are persistent, they accumulate in the environment, wildlife and humans.Although many studies have focused on two of the most representative PFASs, PFOS and PFOA, the potential toxicity of short-chain PFASs has not yet been given sufficient attention.We used a battery of assays to evaluate the toxicity of several four-carbon and six-carbon perfluorinated sulfonates and carboxyl acids(PFBS,PFHxS, PFBA and PFHxA), with a human mesenchymal stem cell(hMSC) system.Our results demonstrate significant cyto-and potential developmental toxicity for all the compounds analyzed, with shared but also distinct mechanisms of toxicity.Moreover, the effects of PFBS and PFHxS were stronger than those of PFBA and PFHxA, but occurred at higher doses compared to PFOS or PFOA.
基金supported by the National Science and Technology Major Project(2023ZD0405001)the National Natural Science Foundation of China(32460837 and 32060176)+3 种基金the Program for Young Talents of Science and Technology in Universities of Inner Mongolia Autonomous Region(NJYT23091)the National Key Research and Development Program of China(2022YFD1302202)the Program of“JIE BANG GUA SHUAI”of Inner Mongolia(2022JBGS0021)the Program of Higher-Level Talents of Inner Mongolia University(10000-21311201/058)。
文摘How a mammalian fertilized egg acquires totipotency and develops into a full-term offspring is a fundamental scientific question.Human embryonic development is difficult to study due to limited resources,technical challenges and ethics.Moreover,the precise regulatory mechanism underlying early human embryonic development remains unknown.In recent years,the emergence of stem cell-based embryo models(SCBEM)provides the opportunity to reconstitute pre-to post-implantation development in vitro.These models to some extent mimic the embryo morphologically and transcriptionally,and thus may be used to study key events in mammalian pre-and post-implantation development.Many groups have successfully generated SCBEM of the mouse and human.Here,we provide a comparative review of the mouse and human SCBEM,discuss the capability of these models to mimic natural embryos and give a perspective on their potential future applications.
文摘Hepatitis C virus (HCV) has emerged as a leading cause of hepatocellular carcinoma (HCC). In most cases, the virus causes HCC in the presence of chronic hepatic inflammation, advanced fibrosis, and cirrhosis. A combination of viral, environmental, and genetic factors are likely to determine the host immune response to the infection as well as the progression to HCC. Clinical and epidemiologic studies have identified many of the risk factors associated with HCC development in patients with chronic hepatitis C. Male sex and older age are considered as independent risk factors for HCC, while alcohol consumption accelerates fibrosis, increasing the risk for progression to HCC. Obesity, diabetes mellitus, nonalcoholic fatty liver disease, aflatoxin exposure and occult hepatitis B infection, all contribute to a higher HCC risk. HCV patients infected with HCV genotype 3 are also more likely to develop HCC and genetic variations such as single nucleotide polymorphisms, which may also alter the risk. Sustained virological response to the antiviral therapy results in significantly more favorable long-term outcomes. The incidence of HCC after HCV eradication is similar between patients treated with peginterferon plus ribavirin and direct-acting antiviral therapy.
基金supported by the National Natural Science Foundation of China (Grant Nos. 22102104, 52175550)the Natural Science Foundation of Shenzhen Science and Technology Commission (Grant Nos. RCBS20200714114920190, JCYJ20220531103409021)+2 种基金Guangdong Basic and Applied Basic Research Foundation (Grant No. 2021A1515010672)the Specific Research Project of Guangxi for Research Bases and Talents (Grant No. 2022AC21200)the Opening Project of the Key Laboratory of Bionic Engineering (Ministry of Education), Jilin University (Grant No. KF20211002)。
文摘Walking on the water surface is an effective method for miniature robots to transport payloads with dramatically decreased interfacial drag. Current aquatic robots reported are generally actuated by a beam of focused light that can trigger asymmetrical deformation, enabling the directional movement through horizontal momentum transfer of photoinduced actuation force to the water. However, the operations are heavily dependent on manual manipulation of the focused light, making the long-term actuation and application of the aquatic robots in vast scenarios challenging. Herein, we developed a kind of water striderinspired robot that can autonomously manage the motion on the water surface under solar irradiation, with their direction steerable by a magnetic field. The motion of this bioinspired robot on the water surface was achieved by the use of a solar cell panel as a driving module to enable propulsive motion based on the conversion of light-electric-mechanical energies. The superhydrophobic design of its leg surfaces enables the aquatic robots with weight-bearing and drag-reducing abilities. With the assistance of magnetic navigation, the bioinspired robot can continuously and controllably locomote to the oily spill floating on the water body and collect them with high efficiency. For further demonstration, the treatment of oil spills in a campus pool with high efficiency has also been achieved. This on-site oil-spill treating strategy, taking advantage of a home-made bioinspired robot actuated by natural sunlight under magnetic steering, shows great potential applications in water-body remediation.
