Tropical calcific pancreatitis(TCP)is a form of chronic non-alcoholic pancreatitis initially reported in the developing parts of the tropical world.The clinical phenotype of TCP has undergone marked changes since its ...Tropical calcific pancreatitis(TCP)is a form of chronic non-alcoholic pancreatitis initially reported in the developing parts of the tropical world.The clinical phenotype of TCP has undergone marked changes since its first description in 1968.The disease is now seen in relatively older people with less severe symptoms.In addition,there are varying reports on the proportion of cases presenting with imaging abnormalities like calcification,ductal dilation,and glandular atrophy.Significant progress has also been made in understanding the etiopathology of TCP.The role of malnutrition and cassava toxicity in its pathogenesis is disproven and few studies have focused on the role of micronutrient deficiency and oxidative stress in the etiopathogenesis of TCP.Emerging evidence support an important role for genetic risk factors in TCP.Several studies have shown that,rather than mutations in trypsinogens,variants in serine protease inhibitor kazal type 1,cathepsin B,chymotrypsin C,cystic fibrosis transmembrane regulator,and carboxypeptidase A1,predict risk of TCP.These studies also provided evidence of mutational heterogeneity between TCP and chronic pancreatitis in Western populations.The current review summarizes recent advances that have implications in the understanding of the pathophysiology and thus,heterogeneity in genotype-phenotype correlations in TCP.展开更多
Aim: To evaluate data related to mental work functioning of workers with cancer diagnosis in radiotherapy in a private service in the city of Campinas, State of São Paulo, Brazil. Method: It consists in a c...Aim: To evaluate data related to mental work functioning of workers with cancer diagnosis in radiotherapy in a private service in the city of Campinas, State of São Paulo, Brazil. Method: It consists in a cross-sectional, observational and analytical study with comparison between cancer patients and healthy people, using the Brazilian version of the Work Role Functioning Questionnaire (WRFQ-Br). Descriptive and statistical analysis is performed by the Mann-Whitney test. Results: There was a significant difference between the groups in the evaluation of mental demand;however, the population diagnosed with malignant neoplasm submitted to radiotherapy had unexpected higher scores, reflecting lower mental exigency. Conclusions: The observed context may occur due to extensive support of family, government and interdisciplinary team of health care for individuals diagnosed with cancer. This data provide support for new research studies related to the importance of the work to promote mental health, considering aspects related to social interaction and productivity as the support system members. The importance of disseminating these results and limitation is based in the necessity of investments to improve research and actions to promote the permanence and early return to work for cancer survivors in Brazil and Latin America.展开更多
OIA （optical image analysis） has traditionally been used for reliable identification of different iron oxides and oxyhydroxides in iron ore. The automated CSIRO OIA system Mineral 4/Recognition 4 was created for rap...OIA （optical image analysis） has traditionally been used for reliable identification of different iron oxides and oxyhydroxides in iron ore. The automated CSIRO OIA system Mineral 4/Recognition 4 was created for rapid mineral and textural charaeterisation of iron ore providing identification of different minerals and different morphologies. The technique has further been applied to processed iron ore products such as iron ore sinter to determine key parameters such as porosity, different morphologies of hematite （primary and secondary）, and different morphologies of SFCA （silicon ferrite of calcium and alumininm）. Application of textural identification has recently been extended to coke characterisation where the software gives comprehensive characterisation of porosity, IMDC （inert material derived components）, RMDC （reactive material derived components） and the boundaries between IMDC and RMDC. The software also has many unique features needed for iron ore research including characterisation of large objects like pellets and ore lumps; automated gangue （including quartz） identification; automated particle separation; multiple image set processing and on-line measurements. All these features make the Mineral 4/Recognition 4OIA system a unique, reliable, industry/research focused tool for ore, sinter, pellet and coke characterisation.展开更多
基金support from the Council of Scientific and Industrial Research,Indian Council of Medical ResearchDepartment of Biotechnology,Government of India,India
文摘Tropical calcific pancreatitis(TCP)is a form of chronic non-alcoholic pancreatitis initially reported in the developing parts of the tropical world.The clinical phenotype of TCP has undergone marked changes since its first description in 1968.The disease is now seen in relatively older people with less severe symptoms.In addition,there are varying reports on the proportion of cases presenting with imaging abnormalities like calcification,ductal dilation,and glandular atrophy.Significant progress has also been made in understanding the etiopathology of TCP.The role of malnutrition and cassava toxicity in its pathogenesis is disproven and few studies have focused on the role of micronutrient deficiency and oxidative stress in the etiopathogenesis of TCP.Emerging evidence support an important role for genetic risk factors in TCP.Several studies have shown that,rather than mutations in trypsinogens,variants in serine protease inhibitor kazal type 1,cathepsin B,chymotrypsin C,cystic fibrosis transmembrane regulator,and carboxypeptidase A1,predict risk of TCP.These studies also provided evidence of mutational heterogeneity between TCP and chronic pancreatitis in Western populations.The current review summarizes recent advances that have implications in the understanding of the pathophysiology and thus,heterogeneity in genotype-phenotype correlations in TCP.
文摘Aim: To evaluate data related to mental work functioning of workers with cancer diagnosis in radiotherapy in a private service in the city of Campinas, State of São Paulo, Brazil. Method: It consists in a cross-sectional, observational and analytical study with comparison between cancer patients and healthy people, using the Brazilian version of the Work Role Functioning Questionnaire (WRFQ-Br). Descriptive and statistical analysis is performed by the Mann-Whitney test. Results: There was a significant difference between the groups in the evaluation of mental demand;however, the population diagnosed with malignant neoplasm submitted to radiotherapy had unexpected higher scores, reflecting lower mental exigency. Conclusions: The observed context may occur due to extensive support of family, government and interdisciplinary team of health care for individuals diagnosed with cancer. This data provide support for new research studies related to the importance of the work to promote mental health, considering aspects related to social interaction and productivity as the support system members. The importance of disseminating these results and limitation is based in the necessity of investments to improve research and actions to promote the permanence and early return to work for cancer survivors in Brazil and Latin America.
文摘OIA （optical image analysis） has traditionally been used for reliable identification of different iron oxides and oxyhydroxides in iron ore. The automated CSIRO OIA system Mineral 4/Recognition 4 was created for rapid mineral and textural charaeterisation of iron ore providing identification of different minerals and different morphologies. The technique has further been applied to processed iron ore products such as iron ore sinter to determine key parameters such as porosity, different morphologies of hematite （primary and secondary）, and different morphologies of SFCA （silicon ferrite of calcium and alumininm）. Application of textural identification has recently been extended to coke characterisation where the software gives comprehensive characterisation of porosity, IMDC （inert material derived components）, RMDC （reactive material derived components） and the boundaries between IMDC and RMDC. The software also has many unique features needed for iron ore research including characterisation of large objects like pellets and ore lumps; automated gangue （including quartz） identification; automated particle separation; multiple image set processing and on-line measurements. All these features make the Mineral 4/Recognition 4OIA system a unique, reliable, industry/research focused tool for ore, sinter, pellet and coke characterisation.
