Purpose We aimed to investigate the effects of running shoe longitudinal bending stiffness(LBS)and midsole energy return on running economy and ankle mechanics and energetics.Methods PubMed,Scopus,SPORTDiscus,Embase,C...Purpose We aimed to investigate the effects of running shoe longitudinal bending stiffness(LBS)and midsole energy return on running economy and ankle mechanics and energetics.Methods PubMed,Scopus,SPORTDiscus,Embase,CINAHL,and Web of Science were systematically searched for this meta-analysis.Crossover studies comparing the effects of running shoe LBS and/or midsole energy return on at least 1 of the following outcomes:running economy,ankle plantarflexion moment,work,power,or angular velocity were included.Results Of the 2453 studies screened,48 were included(n=878).Results indicated that advanced footwear technologies(AFTs)significantly reduced oxygen consumption(standardized mean difference=–0.44,95%confidence interval:–0.60 to–0.28),p<0.001)as well as peak ankle moments and positive/negative ankle work and power.However,neither LBS nor midsole energy return alone significantly affected oxygen consumption,ankle moments,positive and negative work,or positive power.The effects of AFTs were moderated by the training status and speed of the runner.The quality of evidence for all outcomes were low or very low for all outcomes except the effect of LBS on negative ankle work.Conclusion AFT may improve running economy by minimizing ankle moments,work,and power.The absence of significant independent effects of LBS and midsole energy return suggests that the benefits of AFTs arise from the interaction of these properties.Further research is necessary to understand the mechanisms for improved running performance in AFTs.展开更多
Parkinson's disease(PD) has a complex and multifactorial pathophysiology. Various studies, conducted both in pre-clinical models and PD patients, have reported a link between the disruption of calcium(Ca^(2+)) hom...Parkinson's disease(PD) has a complex and multifactorial pathophysiology. Various studies, conducted both in pre-clinical models and PD patients, have reported a link between the disruption of calcium(Ca^(2+)) homeostasis and the subsequent development of PD. Ca^(2+) regulation is crucial for neuronal survival, differentiation,exocytosis at synapses,gene transcription,and proliferation.展开更多
Lithic miniaturization is a key adaptive and technological feature of human populations and one of the key cultural hallmarks in the Late Pleistocene of Eastern Asia.In northern China this form of stone tool technolog...Lithic miniaturization is a key adaptive and technological feature of human populations and one of the key cultural hallmarks in the Late Pleistocene of Eastern Asia.In northern China this form of stone tool technology is well represented,including by microblade technology.Lithic miniaturization has been identified in South China,though this technological feature has received little research attention in comparison to the north.Here,we examine three miniaturized lithic assemblages in South China,ranging from the terminal Pleistocene to middle Holocene.To examine technological variations in lithic miniaturization,the three assemblages were subject to comparative quantitative analyses,including principal component analysis(PCA),K-means clustering and the Zingg system.The three sites were found to exhibit varied temporal and geographic patterns of lithic miniaturization across South China,potentially related to fluctuating climatic conditions and changes in population dynamics since the Late Pleistocene.展开更多
The subcutaneous air pouch model has been used extensively to study the pathophysiology of inflammatory conditions such as joint diseases and the potential efficacy of pharmacological treatments in vivo.Delivery of ai...The subcutaneous air pouch model has been used extensively to study the pathophysiology of inflammatory conditions such as joint diseases and the potential efficacy of pharmacological treatments in vivo.Delivery of air between the subcutaneous and dermal layer of the intra-scapular zone of the rodent generates an environment analogous to the synovial joint space.Introduction of monosodium urate crystals or calcium pyrophosphate crystals into the air space produces a sterile acute inflammatory response mimicking clinical gout and pseudogout,respectively.The inflammatory response can be quantitatively and robustly evaluated by measuring leukocyte infiltration,inflammatory cytokine production,eicosanoid release,complement activation and reactive oxygen species generation.Despite the utility of this model,great variation exists within the literature regarding the design,sampling time points,and endpoints measured.This systematic review summarizes the current literature on the subcutaneous air pouch model studying monosodium urate or calcium pyrophosphate crystals and provides recommendations for standardizing and improving the reliability and validity of this model.Standardizing the experimental approach would improve inter-study comparability,increase the internal validity of studies and reproducibility of results,and ultimately improve the understanding of gout and pseudogout and accelerate the discovery of new pharmacological therapies.展开更多
Shape memory alloy(SMA)bars are currently preferred over elastomeric seismic isolators due to the elimination of degradation within effective damping and stiffness factors during the cyclic response of an isolation sy...Shape memory alloy(SMA)bars are currently preferred over elastomeric seismic isolators due to the elimination of degradation within effective damping and stiffness factors during the cyclic response of an isolation system.These bars could also be used to prevent the functionality of the isolator units from failing due to large deformations.This study aims to investigate the performance of a high damping rubber bearing(HDRB)isolator that is combined with two different types of SMA bars,i.e.,Nickel-Titanium(Ni-Ti)and Copper-Aluminum-Beryllium(Cu-Al-Be),subjected to near-fault ground motions that are characterized with forward directivity and fling step effects.To achieve this objective,a self-centering material with flag-shape,force-deformation hysteresis was utilized to simulate the behavior of SMA bars in OpenSees.A single degree of freedom(SDOF)system representing an isolated one-story shear building was developed to conduct nonlinear analysis under selected ground motions.The SMA bars were introduced as an X-shape within the model and were connected diagonally to the top and bottom of the isolator.Results showed that the HDRB system’s hysteretic response under near-fault ground accelerations experiences significant degradation,especially when near-fault motions involve the fling step effect.It was demonstrated that SMA bars effectively reduce large displacement observed in HDRB systems under near-fault earthquakes.Comparing the results of the base-isolated HDRB and SMA-HDRB subjected to selected ground motions demonstrated that maximum displacement was found to be significantly reduced by an average of 79%when SMA bars were used.Incorporating SMA bars with a larger diameter significantly improves the efficiency of SMA HDRB systems,and a reduction in maximum displacements is more pronounced for fling step,near-fault ground motions.展开更多
Robust preclinical models of transgender male(TGM) gender-affirming hormone therapy(GAHT) can inform clinicians of the isolated effects of GAHT;however existing models vary significantly in approach. We aimed to asses...Robust preclinical models of transgender male(TGM) gender-affirming hormone therapy(GAHT) can inform clinicians of the isolated effects of GAHT;however existing models vary significantly in approach. We aimed to assess existing methodology and how it influences circulating sex-hormone levels in rodent models of TGM GAHT to provide recommendations of best practise. Pub Med, Embase, and Scopus databases were systematically searched for studies that investigated GAHT in rodent models and were published from inception to the 1st of August 2024. Study characteristics and methodology were extracted and compared. Post-intervention circulating sex hormone concentrations were the primary outcome used to determine whether successful gender affirming hormone therapy had been achieved. Sixteen experimental rodent studies were included. Studies were performed on mice( n = 11) and rats( n = 5). Subcutaneous(SC) pellets and SC silastic implants were featured in some studies but weekly SC injections of testosterone enanthate was the preferred method. Sesame oil was the preferred solvent for injected testosterone formulations. Weekly doses of ~ 450 μg(mice) and ~ 420–900 μg(rats) consistently induced the testosterone levels of the male counterpart. Similarly, 10 mg of unesterified testosterone in a SC silastic implant in mice or 10 mg/100 g in rats were also successful methods. Most studies administered hormones for 6–8 weeks before performing post-treatment assessments. This review demonstrates that methods largely varied across studies and successfully identifies the effective methodological approaches that improve the reproducibility and accuracy of preclinical models. Representing an integral step forward to bridging gaps in preclinical transgender healthcare research.展开更多
This paper experimentally investigates the wave pressure and pore pressure within a sandy seabed around two pipelines under the action of random waves(currents).The experiments revealed that when the random wave plus ...This paper experimentally investigates the wave pressure and pore pressure within a sandy seabed around two pipelines under the action of random waves(currents).The experiments revealed that when the random wave plus current cases are compared with the random wave-only case,the forward current promotes wave propagation,whereas the reversed backward current inhibits wave propagation.Furthermore,the wave pressure on the downstream pipeline decreases as the relative spacing ratio increases and increases as the diameter increases.However,alterations in the relative spacing ratio or dimensions of the downstream pipeline exert a negligible influence on the wave pressure of the upstream pipeline.Moreover,the relative spacing ratio between the pipelines and the dimensions of the pipelines considerably influence the pore pressure in the sand bed.When the relative spacing ratio remains constant,increasing the downstream pipeline diameter will increase the pore-water pressure of the soil below the downstream pipeline.展开更多
In recent years,photo-powered energy storage devices have attracted considerable research attention due to their potential applications in smart electronics.In this review,we present a comprehensive summary of recent ...In recent years,photo-powered energy storage devices have attracted considerable research attention due to their potential applications in smart electronics.In this review,we present a comprehensive summary of recent developments in two distinct but highly promising energy storage technologies,photo-assisted metal-air batteries and photo-supercapacitors.The section on metal-air batteries primarily describes the electrochemical performance of Zn-air and Li-air systems,innovative photo-electrode designs,and mechanisms that enhance oxygen evolution and reduction reactions.A brief discussion is also provided of other metal-air systems,including Mg,Fe,and Al.In contrast,the section on photo-supercapacitors explores recent advancements in light-driven charge storage,electrode materials,and device architectures,presenting a comparative performance analysis of materials such as metal oxides,sulfides,and perovskites.Various critical challenges,including material stability,efficiency under varying light conditions,and scalability,are also thoroughly examined.Despite their different working principles,both technologies hold great potential to increase energy efficiency and sustainability through the use of photo-assisted processes.The purpose of this review is to bridge existing knowledge gaps and propose future directions for research in these emerging fields.展开更多
Efficiently executing inference tasks of deep neural networks on devices with limited resources poses a significant load in IoT systems.To alleviate the load,one innovative method is branching that adds extra layers w...Efficiently executing inference tasks of deep neural networks on devices with limited resources poses a significant load in IoT systems.To alleviate the load,one innovative method is branching that adds extra layers with classification exits to a pre-trained model,enabling inputs with high-confidence predictions to exit early,thus reducing inference cost.However,branching networks,not originally tailored for IoT environments,are susceptible to noisy and out-of-distribution(OOD)data,and they demand additional training for optimal performance.The authors introduce BrevisNet,a novel branching methodology designed for creating on-device branching models that are both resourceadaptive and noise-robust for IoT applications.The method leverages the refined uncertainty estimation capabilities of Dirichlet distributions for classification predictions,combined with the superior OOD detection of energy-based models.The authors propose a unique training approach and thresholding technique that enhances the precision of branch predictions,offering robustness against noise and OOD inputs.The findings demonstrate that BrevisNet surpasses existing branching techniques in training efficiency,accuracy,overall performance,and robustness.展开更多
Developing an efficient photocatalyst is the key to realize the practical application of photocatalysis.The S-scheme heterojunction has great potential in photocatalysis due to its unique charge-carrier migration path...Developing an efficient photocatalyst is the key to realize the practical application of photocatalysis.The S-scheme heterojunction has great potential in photocatalysis due to its unique charge-carrier migration pathway,effective light absorption and high redox capacity.However,further enhancing the built-in electric field of the S-scheme,accelerating carrier separation,and achieving higher photocatalytic performance remain unresolved challenges.Herein,based on the continuously adjustable band structure of continuous solid-solution,a novel 0D/2D all solid-solution S-scheme heterojunction with adjustable internal electric field was designed and fabricated by employing a solid-solution of ZnxCd_(1–x)S and Bi_(2)MoyW_(1–y)O_(6)respectively as reduction and oxidation semiconductors.The synergistic optimization of effective light absorption,fast photogenerated carrier separation,and high redox potential leads can be tuned to promote photocatalytic activity.Under visible light,the S-scheme system constructed by Zn_(0.4)Cd_(0.6)S quantum dot(QDs)and Bi_(2)Mo_(0.2)W_(0.8)O_(6)monolayer exhibits a high rate for photocatalytic degradation C_(2)H_(4)(150.6×10^(–3)min^(–1)),which is 16.5 times higher than that of pure Zn_(0.4)Cd_(0.6)S(9.1×10^(–3)min^(–1))and 53.8 times higher than pure Bi_(2)Mo_(0.2)W_(0.8)O_(6)(2.8×10^(–3)min^(–1)).Due to the unique charge-carrier migration pathway,photo-corrosion of Zn_(x)Cd_(1–x)S is further inhibited simultaneously.In-situ irradiation X-ray photoelectron spectroscopy,photoluminescence spectroscopy,time-resolved photoluminescence,transient absorption spectroscopy and electron paramagnetic resonance provide compelling evidence for interfacial charge transfer via S-scheme pathways,while in-situ diffuse reflectance infrared Fourier transform spectroscopy identifies the reaction pathway for C_(2)H_(4)degradation.This novel S-scheme photocatalysts demonstrates excellent performance and potential for the practical application of the fruits and vegetables preservation at room temperatures.展开更多
Gas storage in abandoned mines is one way to reuse waste space resources.The surrounding rock of gas storage reservoirs in underground roadways undergoes damage and deformation under the cyclic loading of gas charging...Gas storage in abandoned mines is one way to reuse waste space resources.The surrounding rock of gas storage reservoirs in underground roadways undergoes damage and deformation under the cyclic loading of gas charging and discharging,which can pose a risk to the safety of the reservoirs.This study establishes a true triaxial numerical model of rock mass with the discrete element method(DEM)and explores the crack evolution of surrounding rock of underground gas storage during cyclic loading and unloading.Also,a damage evolution model in numerical analysis considering residual deformation is developed to explain the experimental results.As was revealed,cyclic loading and unloading resulted in fatigue damage in the specimen and caused strength deterioration of the specimen.During the loading process,the uniformly distributed force chains of the rock mass redistributed,evolving gradually to mostly transverse force chains.This contributed to the appearance of blank areas in the force chains when through cracks appear.The ratio of tensile cracks to shear cracks gradually decreases and finally stabilizes at 7:1.The damage evolution model considering residual strain can be mutually verified with the numerical simulation results.Based on the DEM model,it was found that there was a certain threshold of confining pressure.When the confining pressure exceeded 30 MPa,the deformation to ductility of sandstone samples began to accelerate,with a greater residual strength.This study provides a theoretical basis for analyzing the long-term mechanical behavior of surrounding rock of gas storage in abandoned mines.展开更多
BACKGROUND Pancreatic exocrine insufficiency(PEI)leads to fat malabsorption and maldigestion and is most commonly treated with pancreatic enzyme replacement therapy(PERT).Patients suffering from PEI in China are more ...BACKGROUND Pancreatic exocrine insufficiency(PEI)leads to fat malabsorption and maldigestion and is most commonly treated with pancreatic enzyme replacement therapy(PERT).Patients suffering from PEI in China are more likely not to receive adequate treatment as this drug is not part of the Chinese national essential medicine list.AIM To examine the cost-effectiveness of PERT for patients suffering from PEI in China.METHODS A decision analytical Markov model was constructed to simulate the progress of patients with PEI in China.The population included in the analyses were patients suffering from PEI with advanced(non-resectable)pancreatic cancer,who have undergone surgery due to pancreatic cancer and who have undergone endoscopic treatment due to chronic pancreatitis.The cost-effectiveness analyses were undertaken from a Chinese societal perspective comparing PERT with no PERT.The incremental cost-effectiveness ratio in United States dollars per quality adjusted life year(QALY)gained is the main outcome.Input was informed by publicly available data supplemented with expert clinical advice.RESULTS The cost-effectiveness analyses estimated that PERT resulted in additional 0.45 to 2.93 QALYs at discounted costs of between 4315 dollars to 15193 dollars.This resulted in an incremental cost-effectiveness ratio of 5178 dollars to 9533 dollars per QALY.The one-way sensitivity analyses showed that the main drivers of the model were the cost of PERT and overall survival.CONCLUSION This study demonstrates that PERT is a cost-effective treatment for patients suffering from PEI in China.展开更多
Chloroform and other volatile organic pollutants have garnered widespread attention from the public and researchers,because of their potential harm to the respiratory system,nervous system,skin,and eyes.However,resear...Chloroform and other volatile organic pollutants have garnered widespread attention from the public and researchers,because of their potential harm to the respiratory system,nervous system,skin,and eyes.However,research on chloroform vapor sensing is still in its early stages,primarily due to the lack of specific recognition motif.Here we report a mesoporous photonic crystal sensor incorporating carbon dots-based nanoreceptor(HMSS@CDs-PCs)for enhanced chloroform sensing.The colloidal PC packed with hollow mesoporous silica spheres provides an interconnected ordered macro-meso-hierarchical porous structure,ideal for rapid gas sensing utilizing the photonic bandgap shift as the readout signal.The as-synthesized CDs with pyridinic-N-oxide functional groups adsorbed in the hollow mesoporous silica spheres are found to not only serve as the chloroform adsorption sites,but also a molecular glue that prevents crack formation in the colloidal PC.The sensitivity of HMSS@CDs-PCs sensor is 0.79 nm ppm^(-1)and an impressively low limit of detection is 3.22 ppm,which are the best reported values in fast-response chloroform vapor sensor without multi-signal assistance.The positive response time is 7.5 s and the negative response time 9 s.Furthermore,relatively stable sensing can be maintained within a relative humidity of 20%-85%RH and temperature of 25-55℃.This study demonstrates that HMSS@CDs-PCs sensors have practical application potential in indoor and outdoor chloroform vapor detection.展开更多
Single-atom catalysts(SACs)have demonstrated exceptional performance in electrocatalytic water splitting,owing to their maximized atomic utilization efficiency and superior reaction kinetics.The incorporation of SACs ...Single-atom catalysts(SACs)have demonstrated exceptional performance in electrocatalytic water splitting,owing to their maximized atomic utilization efficiency and superior reaction kinetics.The incorporation of SACs typically depends on robust metal-support interactions,which stabilize the single atoms on the support through various unsaturated chemical sites or spatial confinement.A critical challenge lies in precisely modulating the electronic structure and coordination environment of metal atoms.However,current research primarily focuses on single-atom metals,often neglecting the significant role of support materials in SACs.Two-dimensional(2D)atomically thin materials(ATMs)possess unique physicochemical properties and tunable reaction environments,which can modulate catalytic performance via metal-support interactions,positioning them as promising platforms for SAC loading.This paper reviews the recent advancements and the current status of SACs supported on 2D ATMs(SACs@ATMs).The structural design theory and synthesis strategies of SACs@ATMs are systematically discussed.The significance of advanced characterization techniques in elucidating the coordination environment and metal-support interactions is highlighted.Additionally,the reaction mechanisms and applications of SACs in electrocatalytic water splitting are summarized.Finally,the future challenges and opportunities for SACs@ATMs are outlined.This paper aims to provide insights and guidance for the rational design of SACs@ATMs with high-performance electrocatalytic water splitting capabilities.展开更多
The electrocatalytic furfural oxidation reaction(FFOR)represents an economical and promising technology to replace conventional oxygen evolution reaction,enabling the co-production of high value chemicals and H_(2).Re...The electrocatalytic furfural oxidation reaction(FFOR)represents an economical and promising technology to replace conventional oxygen evolution reaction,enabling the co-production of high value chemicals and H_(2).Regulating the adsorption of furfural(FF)and OH^(-)species holds paramount importance in enhancing the overall performance.Herein,we have developed a unique CuO catalyst enriched with oxygen vacancies(O_(v)-CuO)resulting from the electrochemical reconstruction ofα-Cu_(2)S,which demonstrates exceptional FFOR performance,with a conversion of 95.3%,near-perfect selectivity and Faraday efficiency(FE)for furoic acid(FA)at 1.475 V vs.RHE.The study provides detailed comparison of the structural evolution of different sulfide precatalysts and their impact on FFOR.Furthermore,it delves into the structure-activity relationship through a combination of characterization and theoretical calculations.The O_(v)-CuO not only enhances OH^(-)adsorption,changes the rate-determining step,but also reduces the reaction energy barrier toward FFOR.Additionally,a much lower cell voltage is required to coproduce FA and hydrogen in the two-electrode co-electrolysis system.This work would provide valuable insights into the reaction mechanism of FFOR on Cu based catalysts and establish guidelines for designing defective electrocatalysts for biomass conversion.展开更多
The paleoenvironmental changes and adaptation strategies of hominins during the Late Pleistocene are crucial for understanding the evolution,dispersal,and behavioral shifts of early modern humans.Despite South China&#...The paleoenvironmental changes and adaptation strategies of hominins during the Late Pleistocene are crucial for understanding the evolution,dispersal,and behavioral shifts of early modern humans.Despite South China's significance as a nexus for hominin dispersal and handaxe technology diffusion,quantitative reconstructions of paleoenvironments linked to archaeological records remain scarce.The Sandinggai site(96.6-13.3 ka BP)in central South China,with its well-preserved stratigraphy and abundant lithic artefacts,is notable for providing valuable insights.In this study,quantitative reconstruction of the vegetation succession and climate change sequences at the site was conducted using palynological and isotopic data.The results indicated a shift from a warm-temperate evergreen and deciduous broadleaf mixed forest to a temperate deciduous broadleaf forest,with the climate transitioning from warm and humid to cooler and drier conditions.During the early phase,an increase in lithic production suggested favorable conditions for hominin survival.In the later phase,decreased lithic production and the replacement of large handaxe tools by smaller flake tools,indicated that hominins adapted to the cooler,drier climate and more open landscapes through lithic miniaturization.These findings highlight the environment-driven adaptation of lithic technology and hominin behavior,thereby shedding light on human survival adaptation strategies.展开更多
Fungi play a crucial role in the utilization and storage of soil organic carbon(SOC).Biochars can potentially influence soil carbon(C)turnover by mediating extracellular electron transfer,which can be facilitated by f...Fungi play a crucial role in the utilization and storage of soil organic carbon(SOC).Biochars can potentially influence soil carbon(C)turnover by mediating extracellular electron transfer,which can be facilitated by fungi.However,the effects of biochar and soil type on the community,abundance,enzyme secretion,and necromass of fungi mediating SOC storage remain unclear.A mesocosm incubation experiment was conducted using forest and paddy soils from southern China to study the impact of biochars pyrolyzed at low(300℃BL)and high(700℃BH)temperatures on fungal abundance,community composition,necromass abundance,and C-degrading enzyme activities.The SOC retention ratio was higher under BL(84.0%)than under BH(76.3%).Addition of BL increased fungal abundance in the forest soil by 230%.In contrast,addition of BH decreased fungal abundance in the paddy soil by 20.8%.Biochar addition affected fungal necromass accumulation and oxidase activity and regulated SOC turnover.The high available C content and moderate liming effect of BL significantly increased fungal abundance and necromass abundance in the forest soil compared to the paddy soil.Moreover,after 16 weeks of incubation,BL addition decreased peroxidase activity by 32.1%in the forest soil due to the higher C use efficiency of fungi(i.e.,the enrichment of Talaromyces,Umbelopsis,and Trichoderma),decreasing C-degrading enzyme secretion and reducing SOC degradation compared to the paddy soil.However,BH addition increased the Fusarium abundance,which regulated the polyphenol oxidase activity and promoted SOC degradation in the paddy soil.We concluded that biochars could alter the soil environment and extracellular electron transfer to mediate fungal necromass content and C-degrading enzyme activities,thus affecting SOC storage in the forest and paddy soils.展开更多
Grassland degradation presents overwhelming challenges to biodiversity,ecosystem services,and the socioeconomic sustainability of dependent communities.However,a comprehensive synthesis of global knowledge on the fron...Grassland degradation presents overwhelming challenges to biodiversity,ecosystem services,and the socioeconomic sustainability of dependent communities.However,a comprehensive synthesis of global knowledge on the frontiers and key areas of grassland degradation research has not been achieved due to the limitations of traditional scientometrics methods.The present synthesis of information employed BERTopic,an advanced natural language processing tool,to analyze the extensive ecological literature on grassland degradation.We compiled a dataset of 4,504 publications from the Web of Science core collection database and used it to evaluate the geographic distribution and temporal evolution of different grassland types and available knowledge on the subject.Our analysis identified key topics in the global grassland degradation research domain,including the effects of grassland degradation on ecosystem functions,grassland ecological restoration and biodiversity conservation,erosion processes and hydrological models in grasslands,and others.The BERTopic analysis significantly outperforms traditional methods in identifying complex and evolving topics in large datasets of literature.Compared to traditional scientometrics analysis,BERTopic provides a more comprehensive perspective on the research areas,revealing not only popular topics but also emerging research areas that traditional methods may overlook,although scientometrics offers more specificity and detail.Therefore,we argue for the simultaneous use of both approaches to achieve more systematic and comprehensive assessments of specific research areas.This study represents an emerging application of BERTopic algorithms in ecological research,particularly in the critical research focused on global grassland degradation.It also highlights the need for integrating advanced computational methods in ecological research in this era of data explosion.Tools like the BERTopic algorithm are essential for enhancing our understanding of complex environmental problems,and it marks an important stride towards more sophisticated,data-driven analysis in ecology.展开更多
基金supported by a National Health and Medical Research Council(NHMRC)Investigator Grant Emerging Leadership Level 1(Grant No.2017012).
文摘Purpose We aimed to investigate the effects of running shoe longitudinal bending stiffness(LBS)and midsole energy return on running economy and ankle mechanics and energetics.Methods PubMed,Scopus,SPORTDiscus,Embase,CINAHL,and Web of Science were systematically searched for this meta-analysis.Crossover studies comparing the effects of running shoe LBS and/or midsole energy return on at least 1 of the following outcomes:running economy,ankle plantarflexion moment,work,power,or angular velocity were included.Results Of the 2453 studies screened,48 were included(n=878).Results indicated that advanced footwear technologies(AFTs)significantly reduced oxygen consumption(standardized mean difference=–0.44,95%confidence interval:–0.60 to–0.28),p<0.001)as well as peak ankle moments and positive/negative ankle work and power.However,neither LBS nor midsole energy return alone significantly affected oxygen consumption,ankle moments,positive and negative work,or positive power.The effects of AFTs were moderated by the training status and speed of the runner.The quality of evidence for all outcomes were low or very low for all outcomes except the effect of LBS on negative ankle work.Conclusion AFT may improve running economy by minimizing ankle moments,work,and power.The absence of significant independent effects of LBS and midsole energy return suggests that the benefits of AFTs arise from the interaction of these properties.Further research is necessary to understand the mechanisms for improved running performance in AFTs.
文摘Parkinson's disease(PD) has a complex and multifactorial pathophysiology. Various studies, conducted both in pre-clinical models and PD patients, have reported a link between the disruption of calcium(Ca^(2+)) homeostasis and the subsequent development of PD. Ca^(2+) regulation is crucial for neuronal survival, differentiation,exocytosis at synapses,gene transcription,and proliferation.
基金National Natural Science Foundation of China,No.42177424,No.42488201Youth Innovation Promotion Association of the Chinese Academy of Sciences,No.2020074National Key Research and Development Projects,No.2022YFF0801502。
文摘Lithic miniaturization is a key adaptive and technological feature of human populations and one of the key cultural hallmarks in the Late Pleistocene of Eastern Asia.In northern China this form of stone tool technology is well represented,including by microblade technology.Lithic miniaturization has been identified in South China,though this technological feature has received little research attention in comparison to the north.Here,we examine three miniaturized lithic assemblages in South China,ranging from the terminal Pleistocene to middle Holocene.To examine technological variations in lithic miniaturization,the three assemblages were subject to comparative quantitative analyses,including principal component analysis(PCA),K-means clustering and the Zingg system.The three sites were found to exhibit varied temporal and geographic patterns of lithic miniaturization across South China,potentially related to fluctuating climatic conditions and changes in population dynamics since the Late Pleistocene.
文摘The subcutaneous air pouch model has been used extensively to study the pathophysiology of inflammatory conditions such as joint diseases and the potential efficacy of pharmacological treatments in vivo.Delivery of air between the subcutaneous and dermal layer of the intra-scapular zone of the rodent generates an environment analogous to the synovial joint space.Introduction of monosodium urate crystals or calcium pyrophosphate crystals into the air space produces a sterile acute inflammatory response mimicking clinical gout and pseudogout,respectively.The inflammatory response can be quantitatively and robustly evaluated by measuring leukocyte infiltration,inflammatory cytokine production,eicosanoid release,complement activation and reactive oxygen species generation.Despite the utility of this model,great variation exists within the literature regarding the design,sampling time points,and endpoints measured.This systematic review summarizes the current literature on the subcutaneous air pouch model studying monosodium urate or calcium pyrophosphate crystals and provides recommendations for standardizing and improving the reliability and validity of this model.Standardizing the experimental approach would improve inter-study comparability,increase the internal validity of studies and reproducibility of results,and ultimately improve the understanding of gout and pseudogout and accelerate the discovery of new pharmacological therapies.
基金Open Access funding enabled and organized by CAUL and its Member Institutions。
文摘Shape memory alloy(SMA)bars are currently preferred over elastomeric seismic isolators due to the elimination of degradation within effective damping and stiffness factors during the cyclic response of an isolation system.These bars could also be used to prevent the functionality of the isolator units from failing due to large deformations.This study aims to investigate the performance of a high damping rubber bearing(HDRB)isolator that is combined with two different types of SMA bars,i.e.,Nickel-Titanium(Ni-Ti)and Copper-Aluminum-Beryllium(Cu-Al-Be),subjected to near-fault ground motions that are characterized with forward directivity and fling step effects.To achieve this objective,a self-centering material with flag-shape,force-deformation hysteresis was utilized to simulate the behavior of SMA bars in OpenSees.A single degree of freedom(SDOF)system representing an isolated one-story shear building was developed to conduct nonlinear analysis under selected ground motions.The SMA bars were introduced as an X-shape within the model and were connected diagonally to the top and bottom of the isolator.Results showed that the HDRB system’s hysteretic response under near-fault ground accelerations experiences significant degradation,especially when near-fault motions involve the fling step effect.It was demonstrated that SMA bars effectively reduce large displacement observed in HDRB systems under near-fault earthquakes.Comparing the results of the base-isolated HDRB and SMA-HDRB subjected to selected ground motions demonstrated that maximum displacement was found to be significantly reduced by an average of 79%when SMA bars were used.Incorporating SMA bars with a larger diameter significantly improves the efficiency of SMA HDRB systems,and a reduction in maximum displacements is more pronounced for fling step,near-fault ground motions.
文摘Robust preclinical models of transgender male(TGM) gender-affirming hormone therapy(GAHT) can inform clinicians of the isolated effects of GAHT;however existing models vary significantly in approach. We aimed to assess existing methodology and how it influences circulating sex-hormone levels in rodent models of TGM GAHT to provide recommendations of best practise. Pub Med, Embase, and Scopus databases were systematically searched for studies that investigated GAHT in rodent models and were published from inception to the 1st of August 2024. Study characteristics and methodology were extracted and compared. Post-intervention circulating sex hormone concentrations were the primary outcome used to determine whether successful gender affirming hormone therapy had been achieved. Sixteen experimental rodent studies were included. Studies were performed on mice( n = 11) and rats( n = 5). Subcutaneous(SC) pellets and SC silastic implants were featured in some studies but weekly SC injections of testosterone enanthate was the preferred method. Sesame oil was the preferred solvent for injected testosterone formulations. Weekly doses of ~ 450 μg(mice) and ~ 420–900 μg(rats) consistently induced the testosterone levels of the male counterpart. Similarly, 10 mg of unesterified testosterone in a SC silastic implant in mice or 10 mg/100 g in rats were also successful methods. Most studies administered hormones for 6–8 weeks before performing post-treatment assessments. This review demonstrates that methods largely varied across studies and successfully identifies the effective methodological approaches that improve the reproducibility and accuracy of preclinical models. Representing an integral step forward to bridging gaps in preclinical transgender healthcare research.
基金supported by the National Natural Science Foundation of China(Grant No.52271281)Shandong Provincial High-Level Talent Workstation,Shandong Province Natural Science Foundation Youth project(Grant No.ZR2023QE190)an Open funding project from the Key Laboratory of Ministry of Education for Coastal Disaster and Protection,Hohai University,China(Grant No.202206).
文摘This paper experimentally investigates the wave pressure and pore pressure within a sandy seabed around two pipelines under the action of random waves(currents).The experiments revealed that when the random wave plus current cases are compared with the random wave-only case,the forward current promotes wave propagation,whereas the reversed backward current inhibits wave propagation.Furthermore,the wave pressure on the downstream pipeline decreases as the relative spacing ratio increases and increases as the diameter increases.However,alterations in the relative spacing ratio or dimensions of the downstream pipeline exert a negligible influence on the wave pressure of the upstream pipeline.Moreover,the relative spacing ratio between the pipelines and the dimensions of the pipelines considerably influence the pore pressure in the sand bed.When the relative spacing ratio remains constant,increasing the downstream pipeline diameter will increase the pore-water pressure of the soil below the downstream pipeline.
基金supported by the National Natural Science Foundation of China(Grant No.52263028)Xingdian Talent Funding Project(Year 2022,Yunnan Province,China).
文摘In recent years,photo-powered energy storage devices have attracted considerable research attention due to their potential applications in smart electronics.In this review,we present a comprehensive summary of recent developments in two distinct but highly promising energy storage technologies,photo-assisted metal-air batteries and photo-supercapacitors.The section on metal-air batteries primarily describes the electrochemical performance of Zn-air and Li-air systems,innovative photo-electrode designs,and mechanisms that enhance oxygen evolution and reduction reactions.A brief discussion is also provided of other metal-air systems,including Mg,Fe,and Al.In contrast,the section on photo-supercapacitors explores recent advancements in light-driven charge storage,electrode materials,and device architectures,presenting a comparative performance analysis of materials such as metal oxides,sulfides,and perovskites.Various critical challenges,including material stability,efficiency under varying light conditions,and scalability,are also thoroughly examined.Despite their different working principles,both technologies hold great potential to increase energy efficiency and sustainability through the use of photo-assisted processes.The purpose of this review is to bridge existing knowledge gaps and propose future directions for research in these emerging fields.
基金Australian Research Council,Grant/Award Numbers:DE200101465,DP240101108。
文摘Efficiently executing inference tasks of deep neural networks on devices with limited resources poses a significant load in IoT systems.To alleviate the load,one innovative method is branching that adds extra layers with classification exits to a pre-trained model,enabling inputs with high-confidence predictions to exit early,thus reducing inference cost.However,branching networks,not originally tailored for IoT environments,are susceptible to noisy and out-of-distribution(OOD)data,and they demand additional training for optimal performance.The authors introduce BrevisNet,a novel branching methodology designed for creating on-device branching models that are both resourceadaptive and noise-robust for IoT applications.The method leverages the refined uncertainty estimation capabilities of Dirichlet distributions for classification predictions,combined with the superior OOD detection of energy-based models.The authors propose a unique training approach and thresholding technique that enhances the precision of branch predictions,offering robustness against noise and OOD inputs.The findings demonstrate that BrevisNet surpasses existing branching techniques in training efficiency,accuracy,overall performance,and robustness.
文摘Developing an efficient photocatalyst is the key to realize the practical application of photocatalysis.The S-scheme heterojunction has great potential in photocatalysis due to its unique charge-carrier migration pathway,effective light absorption and high redox capacity.However,further enhancing the built-in electric field of the S-scheme,accelerating carrier separation,and achieving higher photocatalytic performance remain unresolved challenges.Herein,based on the continuously adjustable band structure of continuous solid-solution,a novel 0D/2D all solid-solution S-scheme heterojunction with adjustable internal electric field was designed and fabricated by employing a solid-solution of ZnxCd_(1–x)S and Bi_(2)MoyW_(1–y)O_(6)respectively as reduction and oxidation semiconductors.The synergistic optimization of effective light absorption,fast photogenerated carrier separation,and high redox potential leads can be tuned to promote photocatalytic activity.Under visible light,the S-scheme system constructed by Zn_(0.4)Cd_(0.6)S quantum dot(QDs)and Bi_(2)Mo_(0.2)W_(0.8)O_(6)monolayer exhibits a high rate for photocatalytic degradation C_(2)H_(4)(150.6×10^(–3)min^(–1)),which is 16.5 times higher than that of pure Zn_(0.4)Cd_(0.6)S(9.1×10^(–3)min^(–1))and 53.8 times higher than pure Bi_(2)Mo_(0.2)W_(0.8)O_(6)(2.8×10^(–3)min^(–1)).Due to the unique charge-carrier migration pathway,photo-corrosion of Zn_(x)Cd_(1–x)S is further inhibited simultaneously.In-situ irradiation X-ray photoelectron spectroscopy,photoluminescence spectroscopy,time-resolved photoluminescence,transient absorption spectroscopy and electron paramagnetic resonance provide compelling evidence for interfacial charge transfer via S-scheme pathways,while in-situ diffuse reflectance infrared Fourier transform spectroscopy identifies the reaction pathway for C_(2)H_(4)degradation.This novel S-scheme photocatalysts demonstrates excellent performance and potential for the practical application of the fruits and vegetables preservation at room temperatures.
基金National Natural Science Foundation of China,Grant/Award Numbers:U22A20598,52104107National Key Research and Development Program of China,Grant/Award Numbers:2023YFC2907300,2019YFE0118500,2019YFC1904304Natural Science Foundation of Jiangsu Province,Grant/Award Number:BK20200634。
文摘Gas storage in abandoned mines is one way to reuse waste space resources.The surrounding rock of gas storage reservoirs in underground roadways undergoes damage and deformation under the cyclic loading of gas charging and discharging,which can pose a risk to the safety of the reservoirs.This study establishes a true triaxial numerical model of rock mass with the discrete element method(DEM)and explores the crack evolution of surrounding rock of underground gas storage during cyclic loading and unloading.Also,a damage evolution model in numerical analysis considering residual deformation is developed to explain the experimental results.As was revealed,cyclic loading and unloading resulted in fatigue damage in the specimen and caused strength deterioration of the specimen.During the loading process,the uniformly distributed force chains of the rock mass redistributed,evolving gradually to mostly transverse force chains.This contributed to the appearance of blank areas in the force chains when through cracks appear.The ratio of tensile cracks to shear cracks gradually decreases and finally stabilizes at 7:1.The damage evolution model considering residual strain can be mutually verified with the numerical simulation results.Based on the DEM model,it was found that there was a certain threshold of confining pressure.When the confining pressure exceeded 30 MPa,the deformation to ductility of sandstone samples began to accelerate,with a greater residual strength.This study provides a theoretical basis for analyzing the long-term mechanical behavior of surrounding rock of gas storage in abandoned mines.
文摘BACKGROUND Pancreatic exocrine insufficiency(PEI)leads to fat malabsorption and maldigestion and is most commonly treated with pancreatic enzyme replacement therapy(PERT).Patients suffering from PEI in China are more likely not to receive adequate treatment as this drug is not part of the Chinese national essential medicine list.AIM To examine the cost-effectiveness of PERT for patients suffering from PEI in China.METHODS A decision analytical Markov model was constructed to simulate the progress of patients with PEI in China.The population included in the analyses were patients suffering from PEI with advanced(non-resectable)pancreatic cancer,who have undergone surgery due to pancreatic cancer and who have undergone endoscopic treatment due to chronic pancreatitis.The cost-effectiveness analyses were undertaken from a Chinese societal perspective comparing PERT with no PERT.The incremental cost-effectiveness ratio in United States dollars per quality adjusted life year(QALY)gained is the main outcome.Input was informed by publicly available data supplemented with expert clinical advice.RESULTS The cost-effectiveness analyses estimated that PERT resulted in additional 0.45 to 2.93 QALYs at discounted costs of between 4315 dollars to 15193 dollars.This resulted in an incremental cost-effectiveness ratio of 5178 dollars to 9533 dollars per QALY.The one-way sensitivity analyses showed that the main drivers of the model were the cost of PERT and overall survival.CONCLUSION This study demonstrates that PERT is a cost-effective treatment for patients suffering from PEI in China.
基金supported by the National Key Research and Development Program of China(No.2022YFB3205500)National Natural Science Foundation of China(Nos.U23A20360 and 62303192)QL wishes to thank Water Research Australia(WRA 1144/21)for funding support.
文摘Chloroform and other volatile organic pollutants have garnered widespread attention from the public and researchers,because of their potential harm to the respiratory system,nervous system,skin,and eyes.However,research on chloroform vapor sensing is still in its early stages,primarily due to the lack of specific recognition motif.Here we report a mesoporous photonic crystal sensor incorporating carbon dots-based nanoreceptor(HMSS@CDs-PCs)for enhanced chloroform sensing.The colloidal PC packed with hollow mesoporous silica spheres provides an interconnected ordered macro-meso-hierarchical porous structure,ideal for rapid gas sensing utilizing the photonic bandgap shift as the readout signal.The as-synthesized CDs with pyridinic-N-oxide functional groups adsorbed in the hollow mesoporous silica spheres are found to not only serve as the chloroform adsorption sites,but also a molecular glue that prevents crack formation in the colloidal PC.The sensitivity of HMSS@CDs-PCs sensor is 0.79 nm ppm^(-1)and an impressively low limit of detection is 3.22 ppm,which are the best reported values in fast-response chloroform vapor sensor without multi-signal assistance.The positive response time is 7.5 s and the negative response time 9 s.Furthermore,relatively stable sensing can be maintained within a relative humidity of 20%-85%RH and temperature of 25-55℃.This study demonstrates that HMSS@CDs-PCs sensors have practical application potential in indoor and outdoor chloroform vapor detection.
基金financially supported by the National Oversea Postdoctoral Talent Attraction Programthe Pilot Group Program of the Research Fund for International Senior Scientists(52350710795)the Youth Fund of the National Natural Science Foundation of China(52402288).
文摘Single-atom catalysts(SACs)have demonstrated exceptional performance in electrocatalytic water splitting,owing to their maximized atomic utilization efficiency and superior reaction kinetics.The incorporation of SACs typically depends on robust metal-support interactions,which stabilize the single atoms on the support through various unsaturated chemical sites or spatial confinement.A critical challenge lies in precisely modulating the electronic structure and coordination environment of metal atoms.However,current research primarily focuses on single-atom metals,often neglecting the significant role of support materials in SACs.Two-dimensional(2D)atomically thin materials(ATMs)possess unique physicochemical properties and tunable reaction environments,which can modulate catalytic performance via metal-support interactions,positioning them as promising platforms for SAC loading.This paper reviews the recent advancements and the current status of SACs supported on 2D ATMs(SACs@ATMs).The structural design theory and synthesis strategies of SACs@ATMs are systematically discussed.The significance of advanced characterization techniques in elucidating the coordination environment and metal-support interactions is highlighted.Additionally,the reaction mechanisms and applications of SACs in electrocatalytic water splitting are summarized.Finally,the future challenges and opportunities for SACs@ATMs are outlined.This paper aims to provide insights and guidance for the rational design of SACs@ATMs with high-performance electrocatalytic water splitting capabilities.
基金supported by the Natural Science Foundation of Zhejiang Province(ZCLZ24B0301)the Lhasa Central Government Guiding Local Science and Technology Development Funds(No.LSKJ202458)the National Natural Science Foundation of China(No.22472150)。
文摘The electrocatalytic furfural oxidation reaction(FFOR)represents an economical and promising technology to replace conventional oxygen evolution reaction,enabling the co-production of high value chemicals and H_(2).Regulating the adsorption of furfural(FF)and OH^(-)species holds paramount importance in enhancing the overall performance.Herein,we have developed a unique CuO catalyst enriched with oxygen vacancies(O_(v)-CuO)resulting from the electrochemical reconstruction ofα-Cu_(2)S,which demonstrates exceptional FFOR performance,with a conversion of 95.3%,near-perfect selectivity and Faraday efficiency(FE)for furoic acid(FA)at 1.475 V vs.RHE.The study provides detailed comparison of the structural evolution of different sulfide precatalysts and their impact on FFOR.Furthermore,it delves into the structure-activity relationship through a combination of characterization and theoretical calculations.The O_(v)-CuO not only enhances OH^(-)adsorption,changes the rate-determining step,but also reduces the reaction energy barrier toward FFOR.Additionally,a much lower cell voltage is required to coproduce FA and hydrogen in the two-electrode co-electrolysis system.This work would provide valuable insights into the reaction mechanism of FFOR on Cu based catalysts and establish guidelines for designing defective electrocatalysts for biomass conversion.
基金National Natural Science Foundation of China,No.42471185,No.T2192952National Key Research and Development Program of China,No.2022YFF0801502。
文摘The paleoenvironmental changes and adaptation strategies of hominins during the Late Pleistocene are crucial for understanding the evolution,dispersal,and behavioral shifts of early modern humans.Despite South China's significance as a nexus for hominin dispersal and handaxe technology diffusion,quantitative reconstructions of paleoenvironments linked to archaeological records remain scarce.The Sandinggai site(96.6-13.3 ka BP)in central South China,with its well-preserved stratigraphy and abundant lithic artefacts,is notable for providing valuable insights.In this study,quantitative reconstruction of the vegetation succession and climate change sequences at the site was conducted using palynological and isotopic data.The results indicated a shift from a warm-temperate evergreen and deciduous broadleaf mixed forest to a temperate deciduous broadleaf forest,with the climate transitioning from warm and humid to cooler and drier conditions.During the early phase,an increase in lithic production suggested favorable conditions for hominin survival.In the later phase,decreased lithic production and the replacement of large handaxe tools by smaller flake tools,indicated that hominins adapted to the cooler,drier climate and more open landscapes through lithic miniaturization.These findings highlight the environment-driven adaptation of lithic technology and hominin behavior,thereby shedding light on human survival adaptation strategies.
基金supported by the National Natural Science Foundation of China(Nos.32101397,42177195,42307527,and 42307567)the Guangdong Basic and Applied Basic Research Foundation,China(Nos.2021A1515011559,2024A1515012566,and 2023A1515012248)+1 种基金the Guangdong Foundation for Program of Science and Technology Research,China(No.2023B1212060044)GDAS'Project of Science and Technology Development,China(Nos.2023 GDASZH-2023010103 and 2020GDASYL-20200103074).
文摘Fungi play a crucial role in the utilization and storage of soil organic carbon(SOC).Biochars can potentially influence soil carbon(C)turnover by mediating extracellular electron transfer,which can be facilitated by fungi.However,the effects of biochar and soil type on the community,abundance,enzyme secretion,and necromass of fungi mediating SOC storage remain unclear.A mesocosm incubation experiment was conducted using forest and paddy soils from southern China to study the impact of biochars pyrolyzed at low(300℃BL)and high(700℃BH)temperatures on fungal abundance,community composition,necromass abundance,and C-degrading enzyme activities.The SOC retention ratio was higher under BL(84.0%)than under BH(76.3%).Addition of BL increased fungal abundance in the forest soil by 230%.In contrast,addition of BH decreased fungal abundance in the paddy soil by 20.8%.Biochar addition affected fungal necromass accumulation and oxidase activity and regulated SOC turnover.The high available C content and moderate liming effect of BL significantly increased fungal abundance and necromass abundance in the forest soil compared to the paddy soil.Moreover,after 16 weeks of incubation,BL addition decreased peroxidase activity by 32.1%in the forest soil due to the higher C use efficiency of fungi(i.e.,the enrichment of Talaromyces,Umbelopsis,and Trichoderma),decreasing C-degrading enzyme secretion and reducing SOC degradation compared to the paddy soil.However,BH addition increased the Fusarium abundance,which regulated the polyphenol oxidase activity and promoted SOC degradation in the paddy soil.We concluded that biochars could alter the soil environment and extracellular electron transfer to mediate fungal necromass content and C-degrading enzyme activities,thus affecting SOC storage in the forest and paddy soils.
基金financially supported by the First-Class Curriculum Program at the School of Economics and Management,University of the Chinese Academy of Sciencesthe National Natural Science Foundation of China(42041005)the National Social Science Foundation of China(23BTQ054)。
文摘Grassland degradation presents overwhelming challenges to biodiversity,ecosystem services,and the socioeconomic sustainability of dependent communities.However,a comprehensive synthesis of global knowledge on the frontiers and key areas of grassland degradation research has not been achieved due to the limitations of traditional scientometrics methods.The present synthesis of information employed BERTopic,an advanced natural language processing tool,to analyze the extensive ecological literature on grassland degradation.We compiled a dataset of 4,504 publications from the Web of Science core collection database and used it to evaluate the geographic distribution and temporal evolution of different grassland types and available knowledge on the subject.Our analysis identified key topics in the global grassland degradation research domain,including the effects of grassland degradation on ecosystem functions,grassland ecological restoration and biodiversity conservation,erosion processes and hydrological models in grasslands,and others.The BERTopic analysis significantly outperforms traditional methods in identifying complex and evolving topics in large datasets of literature.Compared to traditional scientometrics analysis,BERTopic provides a more comprehensive perspective on the research areas,revealing not only popular topics but also emerging research areas that traditional methods may overlook,although scientometrics offers more specificity and detail.Therefore,we argue for the simultaneous use of both approaches to achieve more systematic and comprehensive assessments of specific research areas.This study represents an emerging application of BERTopic algorithms in ecological research,particularly in the critical research focused on global grassland degradation.It also highlights the need for integrating advanced computational methods in ecological research in this era of data explosion.Tools like the BERTopic algorithm are essential for enhancing our understanding of complex environmental problems,and it marks an important stride towards more sophisticated,data-driven analysis in ecology.
