The purpose of this study is to gain perspectives on introducing IBCTL(International Baccalaureate Certificate in Teaching and Learning)into graduate school of teacher education in Japan,which are currently providing ...The purpose of this study is to gain perspectives on introducing IBCTL(International Baccalaureate Certificate in Teaching and Learning)into graduate school of teacher education in Japan,which are currently providing advanced teacher training programs aimed at cultivating student agency,a comprehensive set of skills necessary for children living in the future,as advocated by the Organisation for Economic Co-operation and Development(OECD)Education 2030 Project.To achieve this goal,I examined the curriculum and structure that are important for IB teacher training and the introduction of IBCTL.I attempted to achieve this goal by examining the curriculum being developed at a graduate school of teacher education attempting to implement IBCTL and the creation of a syllabus based on that curriculum through lesson planning.As a result,I examined the curriculum and structure as a perspective for introducing IBCTL into graduate school of teacher education in Japan,where advanced teacher training is required.I found that a core curriculum and structure that incorporates the core of the IBCTL into the core of graduate school of teacher education programs is important for implementing an IB education that is aligned with the advancement of teacher training and the development of student agency.展开更多
In the classroom,teachers usually find that students fail to remain focused and think actively.This relatively low classroom participation also affects students'reading and writing abilities.Therefore,it has been ...In the classroom,teachers usually find that students fail to remain focused and think actively.This relatively low classroom participation also affects students'reading and writing abilities.Therefore,it has been a common concern of educational researchers and practitioners worldwide to understand how students'initiative can be stimulated and how students can be fostered to become self-driven readers,thinkers,and writers.Catherine Snow is an expert on language and literacy development in children.展开更多
Questionnaires and interviews are employed in this paper to investigate and analyze the situation with respect to express packaging waste at the Graduate School of the Chinese Academy of Social Sciences(GCASS).The sur...Questionnaires and interviews are employed in this paper to investigate and analyze the situation with respect to express packaging waste at the Graduate School of the Chinese Academy of Social Sciences(GCASS).The survey results show that:(1)the campus receives a large number of express packages and there is,in turn,a considerable amount of packaging waste;(2)there are four main types of express packaging materials:paper packaging,plastic bags,wrapping tapes and package fillers;(3)neither the students nor the school perform well in the recycling of express packaging waste;(4)the samples investigated in this paper can be divided into four categories by cluster analysis,and the author infers from this that the colleges and universities with a large proportion of female students should pay more attention to the issue of recycling of express packaging waste.Several suggestions are presented based on the research results:(1)establishing a campus waste recycling system is the most efficient way to solve the problem of express packaging waste at GCASS;(2)we should advocate for green packaging and manage it from the source of waste generation because most of the express packaging material does not easily degrade naturally,and this represents a huge hidden danger to human health and the environment;(3)the school should cultivate student awareness of environmental protection.If education and penalties are implemented together,the recovery system will run better.展开更多
This study aims to investigate the current status of AI competencies among Chinese high school students using quantitative research methods.By integrating UNESCO’s AI Competency Framework for Students with China’s e...This study aims to investigate the current status of AI competencies among Chinese high school students using quantitative research methods.By integrating UNESCO’s AI Competency Framework for Students with China’s educational practices,a questionnaire was developed.Altogether,300 students from eight high schools joined the research.SPSS 26.0 was used for reliability and validity tests,exploratory factor analysis,and group difference analysis.The results show that the questionnaire has good reliability and validity(Cronbach’sα=0.974,KMO=0.912,Bartlett’s test of sphericity was significant with p<0.001,cumulative variance explained 72.0%).Besides,Chinese high school students’AI competencies exhibit a typical pattern of“strong in technology,weak in ethics,and insufficient in creativity”,with technical application ability(mean=3.7)significantly higher than ethical assessment(mean=3.0)and system design(mean=2.8).What’s more,students in the eastern region have significantly better overall competencies than those in the central and western regions(p<0.05),with the largest gap in the technical application dimension(mean difference=0.7)and the smallest gap in the ethical dimension(mean difference=0.3).The study recommends optimizing high school curricula by adding modules for ethical debates and interdisciplinary projects and promoting equitable distribution of educational resources.This research empirically supports global AI education standardization and offers a scientific basis for AI education policies and curriculum design in China’s high schools.展开更多
BACKGROUND Sex education was introduced early in foreign countries.For example,there is a more systematic sex education system abroad,which can better achieve the popularization of sex education.China's sex educat...BACKGROUND Sex education was introduced early in foreign countries.For example,there is a more systematic sex education system abroad,which can better achieve the popularization of sex education.China's sex education started relatively late,yet there are many problems in the development of sex education in China;for example,college students lack knowledge of sexuality.AIM To explore the perception of sex education among medical college students.METHODS Students majoring in medicine in a medical school were selected as the survey subjects.Anonymous online questionnaires were used to conduct the survey,and the results were analyzed using GraphPad Prism,SPSS,Microsoft Excel,and other software.The questionnaire was administered to understand the source of sexual knowledge,sexual responsibility,mastery of sexual knowledge,and distress caused by sexual problems.RESULTS Most students majoring in medicine had no formal sex education,lacked sexual knowledge,or had a biased understanding of sexual responsibility.This study analyzed future research trends in sex education based on relevant achievements in the Chinese context and abroad to further realize the practical significance and value of sex education popularization in China and provide recommendations for parents and schools at different levels.CONCLUSION Sex education should be conducted among college students,and medical colleges and universities should strengthen scientific sex education.展开更多
The rapid advancement of modern science and technology,coupled with the recent surge in new-energy electric vehicles,has significantly boosted the demand for lithium.This has promoted the development and efficient uti...The rapid advancement of modern science and technology,coupled with the recent surge in new-energy electric vehicles,has significantly boosted the demand for lithium.This has promoted the development and efficient utilization of lepidolite as a lithium source.Therefore,the processes for the flotation of lepidolite have been studied in depth,particularly the development and use of lepidolite flotation collectors and the action mechanism of the collectors on the lepidolite surface.Based on the crystal-structure characteristics of lepidolite minerals,this review focuses on the application of anionic collectors,amine cationic collectors(primary amines,quaternary ammonium salts,ether amines,and Gemini amines),and combined collectors to the flotation behavior of lepidolite as well as the adsorption mechanisms.New directions and technologies for the controllable flotation of lepidolite are proposed,including process improvement,reagent synthesis,and mechanistic research.This analysis demonstrates the need for the further study of the complex environment inside lepidolite and pulp.By using modern analytical detection methods and quantum chemical calculations,research on reagents for the flotation of lepidolite has expanded,providing new concepts and references for the efficient flotation recovery and utilization of lepidolite.展开更多
Spinal cord injury results in permanent loss of neurological functions due to severance of neural networks.Transplantation of neural stem cells holds promise to repair disrupted connections.Yet,ensuring the survival a...Spinal cord injury results in permanent loss of neurological functions due to severance of neural networks.Transplantation of neural stem cells holds promise to repair disrupted connections.Yet,ensuring the survival and integration of neural stem cells into the host neural circuit remains a formidable challenge.Here,we investigated whether modifying the intrinsic properties of neural stem cells could enhance their integration post-transplantation.We focused on phosphatase and tensin homolog(PTEN),a well-characterized tumor suppressor known to critically regulate neuronal survival and axonal regeneration.By deleting Pten in mouse neural stem cells,we observed increased neurite outgrowth and enhanced resistance to neurotoxic environments in culture.Upon transplantation into injured spinal cords,Pten-deficient neural stem cells exhibited higher survival and more extensive rostrocaudal distribution.To examine the potential influence of partial PTEN suppression,rat neural stem cells were treated with short hairpin RNA targeting PTEN,and the PTEN knockdown resulted in significant improvements in neurite growth,survival,and neurosphere motility in vitro.Transplantation of sh PTEN-treated neural stem cells into the injured spinal cord also led to an increase in graft survival and migration to an extent similar to that of complete deletion.Moreover,PTEN suppression facilitated neurite elongation from NSC-derived neurons migrating from the lesion epicenter.These findings suggest that modifying intrinsic signaling pathways,such as PTEN,within neural stem cells could bolster their therapeutic efficacy,offering potential avenues for future regenerative strategies for spinal cord injury.展开更多
This paper examines a model that combines vortex generators and leading-edge tubercles for controlling the laminar separation bubble(LSB)over an airfoil at low Reynolds numbers(Re).This new concept of passive flow con...This paper examines a model that combines vortex generators and leading-edge tubercles for controlling the laminar separation bubble(LSB)over an airfoil at low Reynolds numbers(Re).This new concept of passive flow control technique utilizing a tubercle and vortex generator(VG)close to the leading edge was analyzed numerically for a NACA0015 airfoil.In this study,the Shear Stress Transport(SST)turbulence model was employed in the numerical modelling.Numerical modelling was completed using the ANSYS-Fluent 18.2 solver.Analyses were conducted to investigate the flow pattern and understand the underlying LSB control phenomena that enabled the new passive flow control method to provide this significant performance benefit.The findings indicated that the new concept of passive flow control technique suppressed the formation of an LSB at the suction surface of the NACA0015 airfoil,resulting in a higher lift coefficient and improved aerodynamic performance.Improvements in LSB dynamics and aerodynamic performance through the passive flow control method lead to increased energy output and enhanced stability.展开更多
Lithium–sulfur(Li–S)batteries are promisingcandidates for next-generation energy storagegiven their high energy density and potential low cost.Chemically activated carbon(CAC)is often used fortheir cathodes,because ...Lithium–sulfur(Li–S)batteries are promisingcandidates for next-generation energy storagegiven their high energy density and potential low cost.Chemically activated carbon(CAC)is often used fortheir cathodes,because it has a high specific surfacearea for sulfur loading.We have developed a pressurizedphysical activation(PPA)method that producedan activated carbon(PPAC)with a high specific surfacearea comparable to that of CAC.The pore structure of PPAC could be changed and its use as a cathode material for Li–Sbatteries was investigated.Battery tests at different capacity rates(C-rates)showed that it had a much improved high-rate performancewith a discharge capacity of 900 mAh/(g of sulfur)at 1 C,in contrast to only 600 mAh/(g of sulfur)for CAC.Porestructure analyses showed that PPAC prepared at a high activation temperature(1000℃)had unusual channel-like mesoporesbetween the microdomains that are the basic structural units of artificial carbon materials.These are connected to microporesdeveloped in each microdomain,and deliver ions from the surroundings to the internal pores and vice versa.The well-developedmicropores and mesopores of PPAC respectively ensured the high adsorption of lithium polysulfides and a high rate ofion diffusion.Compared to CAC,PPAC is a high-performance,low-cost cathode material that is promising for use in futureLi–S batteries.展开更多
Neurodegenerative disease is characterized by the presence of inclusion bodies containing abnormal toxic proteins in the central nervous system.Physiologicalα-synuclein exists in the form of a monomer or dimer at the...Neurodegenerative disease is characterized by the presence of inclusion bodies containing abnormal toxic proteins in the central nervous system.Physiologicalα-synuclein exists in the form of a monomer or dimer at the presynaptic nerve terminal.It serves as a key molecule to modulate endocytosis and exocytosis.However,under pathological conditions,α-synuclein adopts different conformations,being converted into toxic oligomers.The molecular weight ofα-synuclein oligomers ranges from 25 to 180 kDa,and they do not form filamentous aggregates ofα-synuclein.Subsequently,α-synuclein oligomers change to aggregates,including protofibrils and fibrils(Miki et al.,2022).This process has been implicated in the pathogenesis of neurodegenerative diseases collectively termed synucleinopathies,which include Parkinson’s disease,dementia with Lewy bodies,and multiple system atrophy(MSA).展开更多
In real-world autonomous driving tests,unexpected events such as pedestrians or wild animals suddenly entering the driving path can occur.Conducting actual test drives under various weather conditions may also lead to...In real-world autonomous driving tests,unexpected events such as pedestrians or wild animals suddenly entering the driving path can occur.Conducting actual test drives under various weather conditions may also lead to dangerous situations.Furthermore,autonomous vehicles may operate abnormally in bad weather due to limitations of their sensors and GPS.Driving simulators,which replicate driving conditions nearly identical to those in the real world,can drastically reduce the time and cost required for market entry validation;consequently,they have become widely used.In this paper,we design a virtual driving test environment capable of collecting and verifying SiLS data under adverse weather conditions using multi-source images.The proposed method generates a virtual testing environment that incorporates various events,including weather,time of day,and moving objects,that cannot be easily verified in real-world autonomous driving tests.By setting up scenario-based virtual environment events,multi-source image analysis and verification using real-world DCUs(Data Concentrator Units)with V2X-Car edge cloud can effectively address risk factors that may arise in real-world situations.We tested and validated the proposed method with scenarios employing V2X communication and multi-source image analysis.展开更多
Planning in lexical-prior-free environments presents a fundamental challenge for evaluating whether large language models(LLMs)possess genuine structural reasoning capabilities beyond lexical memorization.When predica...Planning in lexical-prior-free environments presents a fundamental challenge for evaluating whether large language models(LLMs)possess genuine structural reasoning capabilities beyond lexical memorization.When predicates and action names are replaced with semantically irrelevant random symbols while preserving logical structures,existing direct generation approaches exhibit severe performance degradation.This paper proposes a symbol-agnostic closed-loop planning pipeline that enables models to construct executable plans through systematic validation and iterative refinement.The system implements a complete generate-verify-repair cycle through six core processing components:semantic comprehension extracts structural constraints,language planner generates text plans,symbol translator performs structure-preserving mapping,consistency checker conducts static screening,Stanford Research Institute Problem Solver(STRIPS)simulator executes step-by-step validation,and VAL(Validator)provides semantic verification.A repair controller orchestrates four targeted strategies addressing typical failure patterns including first-step precondition errors andmid-segment statemaintenance issues.Comprehensive evaluation on PlanBench Mystery Blocksworld demonstrates substantial improvements over baseline approaches across both language models and reasoning models.Ablation studies confirm that each architectural component contributes non-redundantly to overall effectiveness,with targeted repair providing the largest impact,followed by deep constraint extraction and stepwise validation,demonstrating that superior performance emerges from synergistic integration of these mechanisms rather than any single dominant factor.Analysis reveals distinct failure patterns betweenmodel types—languagemodels struggle with local precondition satisfaction while reasoning models face global goal achievement challenges—yet the validation-driven mechanism successfully addresses these diverse weaknesses.A particularly noteworthy finding is the convergence of final success rates across models with varying intrinsic capabilities,suggesting that systematic validation and repair mechanisms play a more decisive role than raw model capacity in lexical-prior-free scenarios.This work establishes a rigorous evaluation framework incorporating statistical significance testing and mechanistic failure analysis,providingmethodological contributions for fair assessment and practical insights into building reliable planning systems under extreme constraint conditions.展开更多
Objective:We assessed the risk for physical inactivity due to inadequate health literacy using multivariable analysis in a large middleaged population.Methods:This cross-sectional mail survey using a self-administered...Objective:We assessed the risk for physical inactivity due to inadequate health literacy using multivariable analysis in a large middleaged population.Methods:This cross-sectional mail survey using a self-administered questionnaire was conducted in 2020 and included 33,902 community residents aged 40-64 years from 5 cities in Osaka Prefecture,Japan.Of these,12,446(36.7%)agreed to participate in the survey.After exclusion of those with regular visits to medical institutions and those with missing data,the analysis included 3742 participants.Health literacy was measured by the communicative and critical health literacy(CCHL)scale,and participants were classified into 3 groups(low,medium,and high health literacy groups)by the tertiles of the CCHL scale score.Physical inactivity was defined as not completing at least 150 min of moderate-intensity physical activity throughout the week.Results:After adjustment for age,gender,education level,occupation,economic status,living alone,and stages of health behavior change,the multivariable-adjusted odds ratios(ORs)for physical inactivity were 1.36(95% confidence interval[CI]:1.16-1.59,P<0.001)in the medium health literacy group and 1.70(95%CI:1.36-2.11,P<0.001)in the low health literacy group compared with the high health literacy group.Conclusions:This large-scale study provides compelling evidence that those with inadequate health literacy are at higher risk for physical inactivity among middle-aged adults.展开更多
Background:Minimally invasive distal pancreatectomy(MIDP)is increasingly being used,although its oncologic safety for pancreatic ductal adenocarcinoma(PDAC)remains controversial.In Japan,MIDP for PDAC has limited endo...Background:Minimally invasive distal pancreatectomy(MIDP)is increasingly being used,although its oncologic safety for pancreatic ductal adenocarcinoma(PDAC)remains controversial.In Japan,MIDP for PDAC has limited endorsement due to insufficient data.This study aimed to compare the perioperative and long-term outcomes of open distal pancreatectomy(ODP)and MIDP for PDAC.Methods:We retrospectively analyzed patients with resectable pancreatic body and tail cancer treated with ODP or MIDP(laparoscopic or robotic)between January 2007 and July 2022.The surgical procedures(ODP and MIDP)were compared and the patient characteristics,perioperative outcomes,and long-term outcomes were analyzed.We also compared the outcomes of patients with neoadjuvant chemotherapy(NAC)and without NAC.Results:A total of 72 distal pancreatectomies were performed(37 ODPs and 35 MIDPs).In the upfront group,MIDP resulted in significantly less blood loss than ODP(P<0.01),despite similar operative time.There was no statistically significant difference in the 2-year recurrence-free survival(RFS)rates between ODP and MIDP(39.7%vs.57.8%,P=0.60)or in the overall survival(OS)rates(66.7%vs.74.1%,P=0.43).Similarly,in the NAC group,MIDP resulted in significantly less blood loss than ODP(P=0.01);ODP and MIDP had similar 2-year RFS rates(41.7%and 60.0%,P=0.75)and OS rates(50.0%and 70.0%,P=0.36).The interval from surgery to adjuvant chemotherapy initiation did not significantly differ between the ODP and MIDP subgroups in both the upfront group(P=0.13)and the NAC group(P=0.14).The incidence of recurrence was 64.8%for ODP and 42.8%for MIDP(P=0.06).Both procedures showed similar distributions of local and distant recurrence.Conclusions:MIDP caused less blood loss and had similar oncologic safety compared with ODP.MIDP could become a feasible,minimally invasive option with sufficient oncologic safety for pancreatic body and tail cancers.展开更多
The China-ASEAN Free Trade Area(CAFTA)3.0Upgrade Protocol added a section on“Supply Chain Connectivity,”which emphasizes that all parties recognize the lessons learned from the COVID-19 pandemic and cooperate to enh...The China-ASEAN Free Trade Area(CAFTA)3.0Upgrade Protocol added a section on“Supply Chain Connectivity,”which emphasizes that all parties recognize the lessons learned from the COVID-19 pandemic and cooperate to enhance the resilience of the regional supply chain.This is an inevitable trend amid the current accelerated restructuring of the global supply chain,the complex and severe international economic and trade situation,and the impact on the regional industrial chain.It also represents a fundamental shift and consensus on the logic of supply chain cooperation between China and ASEAN countries—a transformation from“Efficiency First”to“Resilience First.”展开更多
Selective internal radiation therapy using yttrium-90 has been used to treat hepatocellular carcinoma,intrahepatic cholangiocarcinoma,and other malignant tumors that have spread to the liver locally.The authors used t...Selective internal radiation therapy using yttrium-90 has been used to treat hepatocellular carcinoma,intrahepatic cholangiocarcinoma,and other malignant tumors that have spread to the liver locally.The authors used the bibliometric approach in response to the neoplasms,using the keyword“Yttrium 90 AND Liver Neoplasms”as a search parameter and then looked up pertinent English-language literature in the Web of Science core collection database’s selfbuilt database through November 30,2025.For statistical analysis and literature management,EndNote and Excel tools were utilized.In addition to co-citation and emergent keyword analysis of authors,VOSviewer and CiteSpace were utilized for social network and chronological order of countries,institutions,authors,and keywords.The aim of this study was to serve as a reference for future research by methodically sorting through the international research literature on Yttrium 90 treatment of liver neoplasms and summarizing the research status and hot trends in this field.In recent years,research focus has increasingly shifted toward high-quality,multi-center clinical trials that combine SIRT-targeted systemic therapy with hepatectomy following the descending stage.This approach is likely to remain a significant research trend in the field.展开更多
Oral squamous cell carcinoma(OSCC)is a prevalent malignancy with high morbidity and mortality.Globally,about 400000 people are affected,often with a poor quality of life.Its high mortality is mainly due to its aggress...Oral squamous cell carcinoma(OSCC)is a prevalent malignancy with high morbidity and mortality.Globally,about 400000 people are affected,often with a poor quality of life.Its high mortality is mainly due to its aggressive growth and tendency to spread.Epithelial-mesenchymal transition(EMT)is a central regulatory hub driving tumor cell migration and invasion by enabling changes in cell characteristics.During EMT,epithelial cells gradually take on mesenchymal traits,gaining mobility and spreading mo re easily.Recent multi-omics studies show that many cancer cells exist in a hybrid or partial-EMT state,which lies between the full epithelial and mesenchymal forms.Cells in this state are especially invasive and metastatic,with high plasticity that promotes tumor progression.This review summarizes the role of partial-EMT in OSCC,with a focus on how it alters the tumor microenvironment(TME),promotes invasion and metastasis,and influences cancer stem cells(CSCs).We also highlight the link between partial-EMT and treatment resistance in OSCC.Based on these insights,we discuss therapeutic strategies targeting partial-EMT to improve outcomes.Targeting partial-EMT may offer promising strategies to enhance treatment effectiveness and improve patient survival and quality of life.展开更多
In this review,the synthesis,functions,and applications of the polymers containing germanium and tin,which are heavy group 14 elements,in their polymer frameworks are summarized.Germanium and tin can form similar skel...In this review,the synthesis,functions,and applications of the polymers containing germanium and tin,which are heavy group 14 elements,in their polymer frameworks are summarized.Germanium and tin can form similar skeletal structures with their homologues carbon and silicon,whereas the polymers containing germanium and tin show unique properties derived from their large atomic radii and weak binding energies.For example,polygermane and polystannane exhibited light absorption in the UV–visible region and conductivity because of theσ-conjugation through the polymer main-chain constructed byσ-bonds between heavy elements.Theσ-conjugation was affected by the conformational change of the polymer main-chain,and thermochromic properties can be induced.Furthermore,the weak bonds were able to be cleaved homolytically upon photoirradiation,and radicals were subsequently generated.By incorporating hypervalent heavy elements into theπ-conjugated system,it was possible to modulate the electronic structures of theπ-conjugated system throughσ*–π*conjugation with highly coordinated elements.Finally,applications for organic solar cells,organic lightemitting materials,and chemical sensors have been achieved.Herein,representative synthetic methods and unique properties for creating smart materials with germanium and tin will be explained.展开更多
文摘The purpose of this study is to gain perspectives on introducing IBCTL(International Baccalaureate Certificate in Teaching and Learning)into graduate school of teacher education in Japan,which are currently providing advanced teacher training programs aimed at cultivating student agency,a comprehensive set of skills necessary for children living in the future,as advocated by the Organisation for Economic Co-operation and Development(OECD)Education 2030 Project.To achieve this goal,I examined the curriculum and structure that are important for IB teacher training and the introduction of IBCTL.I attempted to achieve this goal by examining the curriculum being developed at a graduate school of teacher education attempting to implement IBCTL and the creation of a syllabus based on that curriculum through lesson planning.As a result,I examined the curriculum and structure as a perspective for introducing IBCTL into graduate school of teacher education in Japan,where advanced teacher training is required.I found that a core curriculum and structure that incorporates the core of the IBCTL into the core of graduate school of teacher education programs is important for implementing an IB education that is aligned with the advancement of teacher training and the development of student agency.
文摘In the classroom,teachers usually find that students fail to remain focused and think actively.This relatively low classroom participation also affects students'reading and writing abilities.Therefore,it has been a common concern of educational researchers and practitioners worldwide to understand how students'initiative can be stimulated and how students can be fostered to become self-driven readers,thinkers,and writers.Catherine Snow is an expert on language and literacy development in children.
文摘Questionnaires and interviews are employed in this paper to investigate and analyze the situation with respect to express packaging waste at the Graduate School of the Chinese Academy of Social Sciences(GCASS).The survey results show that:(1)the campus receives a large number of express packages and there is,in turn,a considerable amount of packaging waste;(2)there are four main types of express packaging materials:paper packaging,plastic bags,wrapping tapes and package fillers;(3)neither the students nor the school perform well in the recycling of express packaging waste;(4)the samples investigated in this paper can be divided into four categories by cluster analysis,and the author infers from this that the colleges and universities with a large proportion of female students should pay more attention to the issue of recycling of express packaging waste.Several suggestions are presented based on the research results:(1)establishing a campus waste recycling system is the most efficient way to solve the problem of express packaging waste at GCASS;(2)we should advocate for green packaging and manage it from the source of waste generation because most of the express packaging material does not easily degrade naturally,and this represents a huge hidden danger to human health and the environment;(3)the school should cultivate student awareness of environmental protection.If education and penalties are implemented together,the recovery system will run better.
基金supported by Research Project on Humanities and Social Sciences in Higher Education Institutions of Guizhou Provincial Department of Education(No.24RWZX060).
文摘This study aims to investigate the current status of AI competencies among Chinese high school students using quantitative research methods.By integrating UNESCO’s AI Competency Framework for Students with China’s educational practices,a questionnaire was developed.Altogether,300 students from eight high schools joined the research.SPSS 26.0 was used for reliability and validity tests,exploratory factor analysis,and group difference analysis.The results show that the questionnaire has good reliability and validity(Cronbach’sα=0.974,KMO=0.912,Bartlett’s test of sphericity was significant with p<0.001,cumulative variance explained 72.0%).Besides,Chinese high school students’AI competencies exhibit a typical pattern of“strong in technology,weak in ethics,and insufficient in creativity”,with technical application ability(mean=3.7)significantly higher than ethical assessment(mean=3.0)and system design(mean=2.8).What’s more,students in the eastern region have significantly better overall competencies than those in the central and western regions(p<0.05),with the largest gap in the technical application dimension(mean difference=0.7)and the smallest gap in the ethical dimension(mean difference=0.3).The study recommends optimizing high school curricula by adding modules for ethical debates and interdisciplinary projects and promoting equitable distribution of educational resources.This research empirically supports global AI education standardization and offers a scientific basis for AI education policies and curriculum design in China’s high schools.
基金Supported by Scientific Research Project of College Students in Liaoning Province,No.S202410164004.
文摘BACKGROUND Sex education was introduced early in foreign countries.For example,there is a more systematic sex education system abroad,which can better achieve the popularization of sex education.China's sex education started relatively late,yet there are many problems in the development of sex education in China;for example,college students lack knowledge of sexuality.AIM To explore the perception of sex education among medical college students.METHODS Students majoring in medicine in a medical school were selected as the survey subjects.Anonymous online questionnaires were used to conduct the survey,and the results were analyzed using GraphPad Prism,SPSS,Microsoft Excel,and other software.The questionnaire was administered to understand the source of sexual knowledge,sexual responsibility,mastery of sexual knowledge,and distress caused by sexual problems.RESULTS Most students majoring in medicine had no formal sex education,lacked sexual knowledge,or had a biased understanding of sexual responsibility.This study analyzed future research trends in sex education based on relevant achievements in the Chinese context and abroad to further realize the practical significance and value of sex education popularization in China and provide recommendations for parents and schools at different levels.CONCLUSION Sex education should be conducted among college students,and medical colleges and universities should strengthen scientific sex education.
基金financially supported by the Excellent Youth Scholars Program of State Key Laboratory of Complex Nonferrous Metal Resource Clean Utilization,Kunming University of Science and Technology,China(No.YXQN-2024003)the Central Government-Guided Local Science and Technology Development Fund Project,China(No.202407AB110022)。
文摘The rapid advancement of modern science and technology,coupled with the recent surge in new-energy electric vehicles,has significantly boosted the demand for lithium.This has promoted the development and efficient utilization of lepidolite as a lithium source.Therefore,the processes for the flotation of lepidolite have been studied in depth,particularly the development and use of lepidolite flotation collectors and the action mechanism of the collectors on the lepidolite surface.Based on the crystal-structure characteristics of lepidolite minerals,this review focuses on the application of anionic collectors,amine cationic collectors(primary amines,quaternary ammonium salts,ether amines,and Gemini amines),and combined collectors to the flotation behavior of lepidolite as well as the adsorption mechanisms.New directions and technologies for the controllable flotation of lepidolite are proposed,including process improvement,reagent synthesis,and mechanistic research.This analysis demonstrates the need for the further study of the complex environment inside lepidolite and pulp.By using modern analytical detection methods and quantum chemical calculations,research on reagents for the flotation of lepidolite has expanded,providing new concepts and references for the efficient flotation recovery and utilization of lepidolite.
基金supported by the National Research Foundation of Korea,Nos.2021R1A2C2006110,2021M3E5D9021364,2019R1A5A2026045(to BGK)the Korea Initiative for Fostering University of Research and Innovation(KIURI)Program of the NRF funded by the MSIT(to HK),No.NRF2021M3H1A104892211(to HSK)。
文摘Spinal cord injury results in permanent loss of neurological functions due to severance of neural networks.Transplantation of neural stem cells holds promise to repair disrupted connections.Yet,ensuring the survival and integration of neural stem cells into the host neural circuit remains a formidable challenge.Here,we investigated whether modifying the intrinsic properties of neural stem cells could enhance their integration post-transplantation.We focused on phosphatase and tensin homolog(PTEN),a well-characterized tumor suppressor known to critically regulate neuronal survival and axonal regeneration.By deleting Pten in mouse neural stem cells,we observed increased neurite outgrowth and enhanced resistance to neurotoxic environments in culture.Upon transplantation into injured spinal cords,Pten-deficient neural stem cells exhibited higher survival and more extensive rostrocaudal distribution.To examine the potential influence of partial PTEN suppression,rat neural stem cells were treated with short hairpin RNA targeting PTEN,and the PTEN knockdown resulted in significant improvements in neurite growth,survival,and neurosphere motility in vitro.Transplantation of sh PTEN-treated neural stem cells into the injured spinal cord also led to an increase in graft survival and migration to an extent similar to that of complete deletion.Moreover,PTEN suppression facilitated neurite elongation from NSC-derived neurons migrating from the lesion epicenter.These findings suggest that modifying intrinsic signaling pathways,such as PTEN,within neural stem cells could bolster their therapeutic efficacy,offering potential avenues for future regenerative strategies for spinal cord injury.
基金the Scientific Research Projects Unit of Erciyes University under contract no:FDS-2022-11532 and FOA-2025-14773.
文摘This paper examines a model that combines vortex generators and leading-edge tubercles for controlling the laminar separation bubble(LSB)over an airfoil at low Reynolds numbers(Re).This new concept of passive flow control technique utilizing a tubercle and vortex generator(VG)close to the leading edge was analyzed numerically for a NACA0015 airfoil.In this study,the Shear Stress Transport(SST)turbulence model was employed in the numerical modelling.Numerical modelling was completed using the ANSYS-Fluent 18.2 solver.Analyses were conducted to investigate the flow pattern and understand the underlying LSB control phenomena that enabled the new passive flow control method to provide this significant performance benefit.The findings indicated that the new concept of passive flow control technique suppressed the formation of an LSB at the suction surface of the NACA0015 airfoil,resulting in a higher lift coefficient and improved aerodynamic performance.Improvements in LSB dynamics and aerodynamic performance through the passive flow control method lead to increased energy output and enhanced stability.
文摘Lithium–sulfur(Li–S)batteries are promisingcandidates for next-generation energy storagegiven their high energy density and potential low cost.Chemically activated carbon(CAC)is often used fortheir cathodes,because it has a high specific surfacearea for sulfur loading.We have developed a pressurizedphysical activation(PPA)method that producedan activated carbon(PPAC)with a high specific surfacearea comparable to that of CAC.The pore structure of PPAC could be changed and its use as a cathode material for Li–Sbatteries was investigated.Battery tests at different capacity rates(C-rates)showed that it had a much improved high-rate performancewith a discharge capacity of 900 mAh/(g of sulfur)at 1 C,in contrast to only 600 mAh/(g of sulfur)for CAC.Porestructure analyses showed that PPAC prepared at a high activation temperature(1000℃)had unusual channel-like mesoporesbetween the microdomains that are the basic structural units of artificial carbon materials.These are connected to microporesdeveloped in each microdomain,and deliver ions from the surroundings to the internal pores and vice versa.The well-developedmicropores and mesopores of PPAC respectively ensured the high adsorption of lithium polysulfides and a high rate ofion diffusion.Compared to CAC,PPAC is a high-performance,low-cost cathode material that is promising for use in futureLi–S batteries.
基金supported by Hirosaki University Priority Research Grant for Future Innovation(to YM),JSPS KAKENHI Grant Numbers 24K10654(to YM)and 23K24209(to KW)the Collaborative Research Project of the Brain Research Institute,Niigata University(to YM).
文摘Neurodegenerative disease is characterized by the presence of inclusion bodies containing abnormal toxic proteins in the central nervous system.Physiologicalα-synuclein exists in the form of a monomer or dimer at the presynaptic nerve terminal.It serves as a key molecule to modulate endocytosis and exocytosis.However,under pathological conditions,α-synuclein adopts different conformations,being converted into toxic oligomers.The molecular weight ofα-synuclein oligomers ranges from 25 to 180 kDa,and they do not form filamentous aggregates ofα-synuclein.Subsequently,α-synuclein oligomers change to aggregates,including protofibrils and fibrils(Miki et al.,2022).This process has been implicated in the pathogenesis of neurodegenerative diseases collectively termed synucleinopathies,which include Parkinson’s disease,dementia with Lewy bodies,and multiple system atrophy(MSA).
基金supported by Institute of Information and Communications Technology Planning and Evaluation(IITP)grant funded by the Korean government(MSIT)(No.2019-0-01842,Artificial Intelligence Graduate School Program(GIST))supported by Korea Planning&Evaluation Institute of Industrial Technology(KEIT)grant funded by the Ministry of Trade,Industry&Energy(MOTIE,Republic of Korea)(RS-2025-25448249+1 种基金Automotive Industry Technology Development(R&D)Program)supported by the Regional Innovation System&Education(RISE)programthrough the(Gwangju RISE Center),funded by the Ministry of Education(MOE)and the Gwangju Metropolitan City,Republic of Korea(2025-RISE-05-001).
文摘In real-world autonomous driving tests,unexpected events such as pedestrians or wild animals suddenly entering the driving path can occur.Conducting actual test drives under various weather conditions may also lead to dangerous situations.Furthermore,autonomous vehicles may operate abnormally in bad weather due to limitations of their sensors and GPS.Driving simulators,which replicate driving conditions nearly identical to those in the real world,can drastically reduce the time and cost required for market entry validation;consequently,they have become widely used.In this paper,we design a virtual driving test environment capable of collecting and verifying SiLS data under adverse weather conditions using multi-source images.The proposed method generates a virtual testing environment that incorporates various events,including weather,time of day,and moving objects,that cannot be easily verified in real-world autonomous driving tests.By setting up scenario-based virtual environment events,multi-source image analysis and verification using real-world DCUs(Data Concentrator Units)with V2X-Car edge cloud can effectively address risk factors that may arise in real-world situations.We tested and validated the proposed method with scenarios employing V2X communication and multi-source image analysis.
基金supported by the Information,Production and Systems Research Center,Waseda University,and partly supported by the Future Robotics Organization,Waseda Universitythe Humanoid Robotics Institute,Waseda University,under the Humanoid Project+1 种基金the Waseda University Grant for Special Research Projects(grant numbers 2024C-518 and 2025E-027)was partly executed under the cooperation of organization between Kioxia Corporation andWaseda University.
文摘Planning in lexical-prior-free environments presents a fundamental challenge for evaluating whether large language models(LLMs)possess genuine structural reasoning capabilities beyond lexical memorization.When predicates and action names are replaced with semantically irrelevant random symbols while preserving logical structures,existing direct generation approaches exhibit severe performance degradation.This paper proposes a symbol-agnostic closed-loop planning pipeline that enables models to construct executable plans through systematic validation and iterative refinement.The system implements a complete generate-verify-repair cycle through six core processing components:semantic comprehension extracts structural constraints,language planner generates text plans,symbol translator performs structure-preserving mapping,consistency checker conducts static screening,Stanford Research Institute Problem Solver(STRIPS)simulator executes step-by-step validation,and VAL(Validator)provides semantic verification.A repair controller orchestrates four targeted strategies addressing typical failure patterns including first-step precondition errors andmid-segment statemaintenance issues.Comprehensive evaluation on PlanBench Mystery Blocksworld demonstrates substantial improvements over baseline approaches across both language models and reasoning models.Ablation studies confirm that each architectural component contributes non-redundantly to overall effectiveness,with targeted repair providing the largest impact,followed by deep constraint extraction and stepwise validation,demonstrating that superior performance emerges from synergistic integration of these mechanisms rather than any single dominant factor.Analysis reveals distinct failure patterns betweenmodel types—languagemodels struggle with local precondition satisfaction while reasoning models face global goal achievement challenges—yet the validation-driven mechanism successfully addresses these diverse weaknesses.A particularly noteworthy finding is the convergence of final success rates across models with varying intrinsic capabilities,suggesting that systematic validation and repair mechanisms play a more decisive role than raw model capacity in lexical-prior-free scenarios.This work establishes a rigorous evaluation framework incorporating statistical significance testing and mechanistic failure analysis,providingmethodological contributions for fair assessment and practical insights into building reliable planning systems under extreme constraint conditions.
基金supported by the Fund for Health Promotion from Osaka Prefecture。
文摘Objective:We assessed the risk for physical inactivity due to inadequate health literacy using multivariable analysis in a large middleaged population.Methods:This cross-sectional mail survey using a self-administered questionnaire was conducted in 2020 and included 33,902 community residents aged 40-64 years from 5 cities in Osaka Prefecture,Japan.Of these,12,446(36.7%)agreed to participate in the survey.After exclusion of those with regular visits to medical institutions and those with missing data,the analysis included 3742 participants.Health literacy was measured by the communicative and critical health literacy(CCHL)scale,and participants were classified into 3 groups(low,medium,and high health literacy groups)by the tertiles of the CCHL scale score.Physical inactivity was defined as not completing at least 150 min of moderate-intensity physical activity throughout the week.Results:After adjustment for age,gender,education level,occupation,economic status,living alone,and stages of health behavior change,the multivariable-adjusted odds ratios(ORs)for physical inactivity were 1.36(95% confidence interval[CI]:1.16-1.59,P<0.001)in the medium health literacy group and 1.70(95%CI:1.36-2.11,P<0.001)in the low health literacy group compared with the high health literacy group.Conclusions:This large-scale study provides compelling evidence that those with inadequate health literacy are at higher risk for physical inactivity among middle-aged adults.
文摘Background:Minimally invasive distal pancreatectomy(MIDP)is increasingly being used,although its oncologic safety for pancreatic ductal adenocarcinoma(PDAC)remains controversial.In Japan,MIDP for PDAC has limited endorsement due to insufficient data.This study aimed to compare the perioperative and long-term outcomes of open distal pancreatectomy(ODP)and MIDP for PDAC.Methods:We retrospectively analyzed patients with resectable pancreatic body and tail cancer treated with ODP or MIDP(laparoscopic or robotic)between January 2007 and July 2022.The surgical procedures(ODP and MIDP)were compared and the patient characteristics,perioperative outcomes,and long-term outcomes were analyzed.We also compared the outcomes of patients with neoadjuvant chemotherapy(NAC)and without NAC.Results:A total of 72 distal pancreatectomies were performed(37 ODPs and 35 MIDPs).In the upfront group,MIDP resulted in significantly less blood loss than ODP(P<0.01),despite similar operative time.There was no statistically significant difference in the 2-year recurrence-free survival(RFS)rates between ODP and MIDP(39.7%vs.57.8%,P=0.60)or in the overall survival(OS)rates(66.7%vs.74.1%,P=0.43).Similarly,in the NAC group,MIDP resulted in significantly less blood loss than ODP(P=0.01);ODP and MIDP had similar 2-year RFS rates(41.7%and 60.0%,P=0.75)and OS rates(50.0%and 70.0%,P=0.36).The interval from surgery to adjuvant chemotherapy initiation did not significantly differ between the ODP and MIDP subgroups in both the upfront group(P=0.13)and the NAC group(P=0.14).The incidence of recurrence was 64.8%for ODP and 42.8%for MIDP(P=0.06).Both procedures showed similar distributions of local and distant recurrence.Conclusions:MIDP caused less blood loss and had similar oncologic safety compared with ODP.MIDP could become a feasible,minimally invasive option with sufficient oncologic safety for pancreatic body and tail cancers.
文摘The China-ASEAN Free Trade Area(CAFTA)3.0Upgrade Protocol added a section on“Supply Chain Connectivity,”which emphasizes that all parties recognize the lessons learned from the COVID-19 pandemic and cooperate to enhance the resilience of the regional supply chain.This is an inevitable trend amid the current accelerated restructuring of the global supply chain,the complex and severe international economic and trade situation,and the impact on the regional industrial chain.It also represents a fundamental shift and consensus on the logic of supply chain cooperation between China and ASEAN countries—a transformation from“Efficiency First”to“Resilience First.”
文摘Selective internal radiation therapy using yttrium-90 has been used to treat hepatocellular carcinoma,intrahepatic cholangiocarcinoma,and other malignant tumors that have spread to the liver locally.The authors used the bibliometric approach in response to the neoplasms,using the keyword“Yttrium 90 AND Liver Neoplasms”as a search parameter and then looked up pertinent English-language literature in the Web of Science core collection database’s selfbuilt database through November 30,2025.For statistical analysis and literature management,EndNote and Excel tools were utilized.In addition to co-citation and emergent keyword analysis of authors,VOSviewer and CiteSpace were utilized for social network and chronological order of countries,institutions,authors,and keywords.The aim of this study was to serve as a reference for future research by methodically sorting through the international research literature on Yttrium 90 treatment of liver neoplasms and summarizing the research status and hot trends in this field.In recent years,research focus has increasingly shifted toward high-quality,multi-center clinical trials that combine SIRT-targeted systemic therapy with hepatectomy following the descending stage.This approach is likely to remain a significant research trend in the field.
基金funded by JSPS KAKENHI to Y.K.(22K19629,22H03288,and 21KK0162)JSPS Program for Forming Japan's Peak Research Universities:J-PEAKS(JPJS00420240022)to Y.K.JST SPRING,Grant Number JPMJSP2113 to C.W.and C.S.
文摘Oral squamous cell carcinoma(OSCC)is a prevalent malignancy with high morbidity and mortality.Globally,about 400000 people are affected,often with a poor quality of life.Its high mortality is mainly due to its aggressive growth and tendency to spread.Epithelial-mesenchymal transition(EMT)is a central regulatory hub driving tumor cell migration and invasion by enabling changes in cell characteristics.During EMT,epithelial cells gradually take on mesenchymal traits,gaining mobility and spreading mo re easily.Recent multi-omics studies show that many cancer cells exist in a hybrid or partial-EMT state,which lies between the full epithelial and mesenchymal forms.Cells in this state are especially invasive and metastatic,with high plasticity that promotes tumor progression.This review summarizes the role of partial-EMT in OSCC,with a focus on how it alters the tumor microenvironment(TME),promotes invasion and metastasis,and influences cancer stem cells(CSCs).We also highlight the link between partial-EMT and treatment resistance in OSCC.Based on these insights,we discuss therapeutic strategies targeting partial-EMT to improve outcomes.Targeting partial-EMT may offer promising strategies to enhance treatment effectiveness and improve patient survival and quality of life.
基金supported by Japan Society for the Promotion of Science(JSPS),a Grant-in-Aid for Scientific Research(B)(JP23K23398)(for M.G.)and(JP24K01570)(for K.T.).
文摘In this review,the synthesis,functions,and applications of the polymers containing germanium and tin,which are heavy group 14 elements,in their polymer frameworks are summarized.Germanium and tin can form similar skeletal structures with their homologues carbon and silicon,whereas the polymers containing germanium and tin show unique properties derived from their large atomic radii and weak binding energies.For example,polygermane and polystannane exhibited light absorption in the UV–visible region and conductivity because of theσ-conjugation through the polymer main-chain constructed byσ-bonds between heavy elements.Theσ-conjugation was affected by the conformational change of the polymer main-chain,and thermochromic properties can be induced.Furthermore,the weak bonds were able to be cleaved homolytically upon photoirradiation,and radicals were subsequently generated.By incorporating hypervalent heavy elements into theπ-conjugated system,it was possible to modulate the electronic structures of theπ-conjugated system throughσ*–π*conjugation with highly coordinated elements.Finally,applications for organic solar cells,organic lightemitting materials,and chemical sensors have been achieved.Herein,representative synthetic methods and unique properties for creating smart materials with germanium and tin will be explained.
