In today’s world some changes have been occurred in human lifestyle,these changes,along with the advantages,have led to a series of disadvantages including their disconnection with the nature.One of the most importan...In today’s world some changes have been occurred in human lifestyle,these changes,along with the advantages,have led to a series of disadvantages including their disconnection with the nature.One of the most important areas to re-establish the relationship is the school.The presence of nature at schools,and holding some classes in nature,in addition to meeting the special needs of children causes their separation from those small and boring classes as well as their interest in courses.This study aimed to investigate the role of nature in children’s learning.For this purpose,third,fourth and fifth grade classes of 3 schools were held outside the school environment and in the nature in 5 courses.The study is a combinational research and field,indirect observation and library data collection methods were applied,where in the indirect observation,two types of questionnaires were prepared related to the students and teachers and were randomly distributed among 580 students and 50 elementary school teachers.Test reliability was assessed using Cronbach’s alpha and it was obtained to be 0.890.The results of this study indicate that the physical place as one of the factors in children’s learning has the maximum impact on teaching and learning of children.At the end of the study and by investigating the existing factors in the environment we understood that the expansion of the nature and natural light of it causes the students’interest in lessons in nature.展开更多
Repetitive traumatic brain injury impacts adult neurogenesis in the hippocampal dentate gyrus,leading to long-term cognitive impairment.However,the mechanism underlying this neurogenesis impairment remains unknown.In ...Repetitive traumatic brain injury impacts adult neurogenesis in the hippocampal dentate gyrus,leading to long-term cognitive impairment.However,the mechanism underlying this neurogenesis impairment remains unknown.In this study,we established a male mouse model of repetitive traumatic brain injury and performed long-term evaluation of neurogenesis of the hippocampal dentate gyrus after repetitive traumatic brain injury.Our results showed that repetitive traumatic brain injury inhibited neural stem cell proliferation and development,delayed neuronal maturation,and reduced the complexity of neuronal dendrites and spines.Mice with repetitive traumatic brain injuryalso showed deficits in spatial memory retrieval.Moreover,following repetitive traumatic brain injury,neuroinflammation was enhanced in the neurogenesis microenvironment where C1q levels were increased,C1q binding protein levels were decreased,and canonical Wnt/β-catenin signaling was downregulated.An inhibitor of C1 reversed the long-term impairment of neurogenesis induced by repetitive traumatic brain injury and improved neurological function.These findings suggest that repetitive traumatic brain injury–induced C1-related inflammation impairs long-term neurogenesis in the dentate gyrus and contributes to spatial memory retrieval dysfunction.展开更多
Background:Ferroptosis is a type of regulated cell death characterized by iron-dependent lipid peroxidation,which has been linked to tumor progression and therapeutic resistance.However,the contribution of lactate met...Background:Ferroptosis is a type of regulated cell death characterized by iron-dependent lipid peroxidation,which has been linked to tumor progression and therapeutic resistance.However,the contribution of lactate metabolism and its receptor,hydroxycarboxylic acid receptor 1(HCAR1),in ferroptosis regulation in gastric cancer(GC)remains poorly understood.Focusing specifically on its effects on cell proliferation,ferroptosis regulation,and the disruption of lactate-mediatedmetabolic pathways,the study aimed to clarify the role ofHCAR1 in GC progression.Methods:Bioinformatics analysis identified prognostic genes associated with ferroptosis in GC.Receiver operating characteristic(ROC)curves were generated to assess the diagnostic potential of the predictive genes.The biological role of HCAR1 was investigated through gain and loss-of-function experiments in GC cell lines,followed by assessments of cell viability,oxidative stress indicators,gene/protein expression,and ferroptosis sensitivity under lactate stimulation or HCAR1modulation.Results:HCAR1 was significantly upregulated in GC tissues and linked to poor patient outcomes.Silencing HCAR1 inhibited GC cell growth and induced ferroptosis,as shown by increased levels of reactive oxygen species(ROS)and malondialdehyde(MDA),along with decreased expression of solute carrier family 7 member 11(SLC7A11)and glutathione peroxidase 4(GPX4).Conversely,HCAR1 overexpression or exposure to extracellular lactate inhibited ferroptosis and activated antioxidant defenses.Mechanistically,lactate activation of HCAR1 increases ATP levels,which in turn inactivates AMP-activated protein kinase(AMPK).It also upregulates stearoyl-CoA desaturase 1(SCD1)through the sterol regulatory element binding protein 1(SREBP1)signaling pathway.Blocking HCAR1 reversed these effects and restored ferroptosis sensitivity.Conclusion:HCAR1 mediates lactate-driven ferroptosis resistance in GC through the AMPK-SCD1 signaling pathway.Targeting the HCAR1-lactate axis may offer a promising strategy for overcoming metabolic adaptation and improving GC treatment outcomes.展开更多
BACKGROUND Recurrence of common bile duct(CBD)calculi within 30 days following T-tube cholangiography is exceedingly rare.CASE SUMMARY This article details an instance of choledocholithiasis involving a 1.2 cm×0....BACKGROUND Recurrence of common bile duct(CBD)calculi within 30 days following T-tube cholangiography is exceedingly rare.CASE SUMMARY This article details an instance of choledocholithiasis involving a 1.2 cm×0.9 cm stone located in the lower and middle segments of the CBD,identified 30 days after T-tube cholangiography,accompanied by multiple microstones.Magnetic resonance cholangiopancreatography revealed dilation of both intrahepatic and extrahepatic bile ducts,with the widest segment of the CBD measuring approximately 2 cm.The patient underwent laparoscopic choledochal exploration followed by choledochojejunostomy using the Roux-en-Y technique.CONCLUSION Although recurrence of choledocholithiasis within such a short postoperative period is exceedingly uncommon,this case underscores the necessity for clinicians to remain vigilant regarding the potential for early postoperative recurrence.展开更多
According to the characteristic of cruise missiles,navigation point setting is simplified,and the principle of route planning for saturation attack and a concept of reference route are put forward.With the help of the...According to the characteristic of cruise missiles,navigation point setting is simplified,and the principle of route planning for saturation attack and a concept of reference route are put forward.With the help of the shortest-tangent idea in route-planning and the algorithm of back reasoning from targets,a reference route algorithm is built on the shortest range and threat avoidance.Then a route-flight-time algorithm is built on navigation points.Based on the conditions of multi-direction saturation attack,a route planning algorithm of multi-direction saturation attack is built on reference route,route-flight-time,and impact azimuth.Simulation results show that the algorithm can realize missiles fired in a salvo launch reaching the target simultaneously from different directions while avoiding threat.展开更多
A series solution of displacement response of the ground surface in the presence of underground twin tunnels subjected to excitation of incident plane SV waves is derived by using Fourier-Bessel series expansion metho...A series solution of displacement response of the ground surface in the presence of underground twin tunnels subjected to excitation of incident plane SV waves is derived by using Fourier-Bessel series expansion method.The numerical parametric study shows that underground twin tunnels significantly amplify the nearby surface ground motion.It is suggested that the effect of subways on ground motion should be considered when the subways are planned and designed.展开更多
Peripheral facial paralysis is a frequently encountered disease with a high incidence, and it is one of the most common diseases in acupuncture and moxibustion treatment. Because there are rich
AIM:To investigate mortality reduction from gastric cancer based on the results of endoscopic screening.METHODS:The study population consisted of participants of gastric cancer screening by endoscopy,regular radiograp...AIM:To investigate mortality reduction from gastric cancer based on the results of endoscopic screening.METHODS:The study population consisted of participants of gastric cancer screening by endoscopy,regular radiography,and photofluorography at Niigata city in 2005.The observed numbers of cumulative deaths from gastric cancers and other cancers were accumulated by linkage with the Niigata Prefectural Cancer Registry.The standardized mortality ratio(SMR)of gastric cancer and other cancer deaths in each screening group was calculated by applying the mortality rate of the reference population.RESULTS:Based on the results calculated from the mortality rate of the population of Niigata city,the SMRs of gastric cancer death were 0.43(95%CI:0.30-0.57)for the endoscopic screening group,0.68(95%CI:0.55-0.79)for the regular radiographic screening group,and 0.85(95%CI:0.71-0.94)for the photofluorography screening group.The mortality reduction from gastric cancer was higher in the endoscopic screening group than in the regular radiographic screening group despite the nearly equal mortality rates of all cancers except gastric cancer.CONCLUSION:The 57%mortality reduction from gastric cancer might indicate the effectiveness of endoscopic screening for gastric cancer.Further studies and prudent interpretation of results are needed.展开更多
BACKGROUND Reports in the field of robotic surgery for rectal cancer are increasing year by year.However,most of these studies enroll patients at a relatively early stage and have small sample sizes.In fact,studies on...BACKGROUND Reports in the field of robotic surgery for rectal cancer are increasing year by year.However,most of these studies enroll patients at a relatively early stage and have small sample sizes.In fact,studies only on patients with locally advanced rectal cancer(LARC)and with relatively large sample sizes are lacking.AIM To investigate whether the short-term outcomes differed between robotic-assisted proctectomy(RAP)and laparoscopic-assisted proctectomy(LAP)for LARC.METHODS The clinicopathological data of patients with LARC who underwent robotic-or laparoscopic-assisted radical surgery between January 2015 and October 2019 were collected retrospectively.To reduce patient selection bias,we used the clinical baseline characteristics of the two groups of patients as covariates for propensity-score matching(PSM)analysis.Short-term outcomes were compared between the two groups.RESULTS The clinical features were well matched in the PSM cohort.Compared with the LAP group,the RAP group had less intraoperative blood loss,lower volume of pelvic cavity drainage,less time to remove the pelvic drainage tube and urinary catheter,longer distal resection margin and lower rates of conversion(P<0.05).However,the time to recover bowel function,the harvested lymph nodes,the postoperative length of hospital stay,and the rate of unplanned readmission within 30 days postoperatively showed no difference between the two groups(P>0.05).The rates of total complications and all individual complications were similar between the RAP and LAP groups(P>0.05).CONCLUSION This retrospective study indicated that RAP is a safe and feasible method for LARC with better short-term outcomes than LAP,but we have to admit that the clinically significant of part of indicators are relatively small in the practical situation.展开更多
The application of multi-hull ship or trimaran vessel as a mode of transports in both river and sea environments have grown rapidly in recent years.Trimaran vessels are currently of interest for many new high speed sh...The application of multi-hull ship or trimaran vessel as a mode of transports in both river and sea environments have grown rapidly in recent years.Trimaran vessels are currently of interest for many new high speed ship projects due to the high levels of hydrodynamic efficiency that can be achieved,compared to the mono-hull and catamaran hull forms.The purpose of this study is to identify the possible effects of using an unsymmetrical trimaran ship model with configuration（S/L） 0.1-0.3 and R/L=0.1-0.2.Unsymmetrical trimaran ship model with main dimensions： L=2000mm,B=200 mm and T=45 mm.Experimental methods（towing tank） were performed in the study using speed variations at Froude number 0.1-0.6.The ship model was pulled by an electric motor whose speed could be varied and adjusted.The ship model resistance was measured precisely by using a load cell transducer.The comparison of ship resistance for each configuration with mono-hull was shown on the graph as a function of the total resistance coefficient and Froude number.The test results found that the effective drag reduction could be achieved up to 17% at Fr=0.35 with configuration S/L=0.1.展开更多
Continuous annealing simulation tests were conducted by using a continuous annealing thermomechanical simulator. Holding times of 5, 60, 180, and 480 seconds for an intercritical annealing temperature of 820℃ were ad...Continuous annealing simulation tests were conducted by using a continuous annealing thermomechanical simulator. Holding times of 5, 60, 180, and 480 seconds for an intercritical annealing temperature of 820℃ were adopted to investigate the evolution of the mierostructure and mechanical properties of ferrite-bainite dual-phase steel. The ferrite-bainite dual-phase steel was characterized by high strength and low yield ratio due to the presence of the constituents （polygonal ferrite, bainite, martensite and retained austenite） of the steel microstructure. Specimen 3 exhibits the highest value of A50 （7.67%） and a product of Rm × A50 （10453MPa%） after a 180s holding. This is likely attributed to the presence of a C-enriched retained anstenite in the microstructure. And the effect of martensite islands and carbide precipitate is thought to be able to contribute in strengthening the present steel. It is expected that equilibrium of anstenite fraction would be reached for reasonable intercritical holding period, regardless of the heating temperature. The results suggest that long increasing holding times may not be needed because the major phase of the microstructure does not change very significantly. It is favorable for industrial production of DP steels to shorten holding times. Key words： ferrite-bainite dual-phase steel; holding time; martensite islands; mechanical properties展开更多
Accelerated degradation test is a useful approach to predict the product lifetime at the normal use stress level, especially for highly reliable products. Two kinds of the lifetime prediction based on Gamma processes ...Accelerated degradation test is a useful approach to predict the product lifetime at the normal use stress level, especially for highly reliable products. Two kinds of the lifetime prediction based on Gamma processes were studied. One was to predict the lifetime of the population from accelerated degradation data, and the other was to predict the lifetime of an individual by taking the accelerated degradation data as prior information. For an extensive application, the Gamma process with a time transformation and random effects was considered. A novel contribution is that a deducing method for determining the relationships between the shape and scale parameters of Gamma processes and accelerated stresses was presented. When predicting the lifetime of an individual, Bayesian inference methods were adopted to improve the prediction accuracy, in which the conjugate prior distribution and the non-conjugate prior distribution of random parameters were studied. The conjugate prior distribution only considers the random effect of the scale parameter while the non-conjugate prior distribution considers the random effects of both the scale and shape parameter. The application and usefulness of the proposed method was demonstrated by the accelerated degradation data of carbon-film resistors.展开更多
The shrinkage and chilling tendency of spheroidal graphite (abbreviated SG) cast iron is much greater than that of the flake graphite cast iron in spite of its higher amount of C and Si contents. Why? The main reason ...The shrinkage and chilling tendency of spheroidal graphite (abbreviated SG) cast iron is much greater than that of the flake graphite cast iron in spite of its higher amount of C and Si contents. Why? The main reason should be the difference in their graphitization during the eutectic solidification. In this paper, we discuss the difference in the solidification mechanism of both cast irons for solving these problems using unidirectional solidification and the cooling curves of the spheroidal graphite cast iron. The eutectic solidification rate of the SG cast iron is controlled by the diffusion of carbon through the austenite shell, and the final thickness is 1.4 times the radius of the SG, therefore, the reduction of the SG size, namely, the increase in the number, is the main solution of these problems.展开更多
Objective. To investigate the relationship of plasma homocysteine (Hcy) level to stroke and genetic factor to elevated plasma Hcy level.Methods. The plasma Hcy level was measured by capillary electrophoresis- ultravio...Objective. To investigate the relationship of plasma homocysteine (Hcy) level to stroke and genetic factor to elevated plasma Hcy level.Methods. The plasma Hcy level was measured by capillary electrophoresis- ultraviolet detection and the gene polymorphism of N5, N10 - methylenetetrahydrofolate reductase (MTHFR) was studied with PCR - RFLP assay in 43 patients with cortical cerebral infarction and 42 healthy controls.Results. The plasma Hcy level of the patients ( 19. 3 + 6. 0 μ mol/L) was markedly higher than that of the controls (13.7 + 5.4 μ mol/L) ( t = 4. 16, P ＜ 0. 001). There are 3 genotypes, C/C, C/T and T/T, about base - variation of MTHFR gene at locus 677. The plasma Hcy level of the subjects with T/T genotype was higher than that of subjects with other genotypes. However, the frequencies of each genotype and allele were not significantly different between the patients and the controls.Conclusions. The elevated plasma Hcy level is a risk factor for atherothrombotic cerebral infarction, and is related to the C→T mutation at locus 677 of MTHFR gene.展开更多
A novel time-domain identification technique is developed for the seismic response analysis of soil-structure interaction.A two-degree-of-freedom (2DOF) model with eight lumped parameters is adopted to model the frequ...A novel time-domain identification technique is developed for the seismic response analysis of soil-structure interaction.A two-degree-of-freedom (2DOF) model with eight lumped parameters is adopted to model the frequency- dependent behavior of soils.For layered soil,the equivalent eight parameters of the 2DOF model are identified by the extended Kalman filter (EKF) method using recorded seismic data.The polynomial approximations for derivation of state estimators are applied in the EKF procedure.A realistic identification example is given for the layered-soil of a building site in Anchorage,Alaska in the United States.Results of the example demonstrate the feasibility and practicality of the proposed identification technique.The 2DOF soil model and the identification technique can be used for nonlinear response analysis of soil-structure interaction in the time-domain for layered or complex soil conditions.The identified parameters can be stored in a database tor use in other similar soil conditions,lfa universal database that covers information related to most soil conditions is developed in the thture,engineers could conveniently perform time history analyses of soil-structural interaction.展开更多
Objective:To observe changes in the molecular expression of the NLR Family Pyrin Domain Containing Protein 3(NLRP3)pathway in depressed rats after treatment with Xiaoyaosan,and identify the regulatory mechanism of thi...Objective:To observe changes in the molecular expression of the NLR Family Pyrin Domain Containing Protein 3(NLRP3)pathway in depressed rats after treatment with Xiaoyaosan,and identify the regulatory mechanism of this compound.Methods:Male SpragueeD awley rats were randomly divided into five groups with 12 rats in each group,including the control group,model group,Fluoxetine group,Xiaoyaosan group,and MCC950 group.A depression model was generated by chronic immobilization stress(induced by 3 h of restraint immobilization every day),and the drugs were administered at the same time in each group for 21 days.The effects of Xiaoyaosan on behavioral changes of depressed rats were observed through macroscopic characterization,body mass,open field experiments,and a sucrose preference test.The m RNA and protein expression of the NLRP3 signaling pathway was examined by fluorescence real-time quantitative PCR and Western blot assays.Results:The Xiaoyaosan group,Fluoxetine group,and MCC950 group rats showed improved depressive behavior and an increased weight of sucrose water consumption.The protein and mRNA expression levels of NLRP3,Caspase-1,and IL-1 b were also decreased in the Fluoxetine,Xiaoyaosan,and MCC950 groups.Conclusion:NLRP3,Caspase-1,and IL-1 b protein and mRNA expression levels were increased in the cortex of depressed rats,while Xiaoyaosan protected cortical tissue in these rats by decreasing NLRP3,Caspase-1,and IL-1 b protein and mRNA expression.展开更多
The present study was undertaken to determine the effects of different levels of urea-N fertilizer in addition to ipil-ipil tree litter on yield of rice and insect prevalence. The field study was conducted at the Agro...The present study was undertaken to determine the effects of different levels of urea-N fertilizer in addition to ipil-ipil tree litter on yield of rice and insect prevalence. The field study was conducted at the Agroforestry Field Laboratory, Bangladesh Agricultural University, Mymensingh during July-December 2004. The treatments included 0, 90, 180, and 270 kg urea per hectare. All four treatments received five tons ipil-ipil tree litter per hectare. The experiment was laid out in a randomized complete block design （RCBD） with four replications. The results showed that the different treatments significantly influenced the yield and yield component viz. total tillers/hill, effective tillers/hill, filled grains and unfilled grains/panicle. The highest yield of 4.62 t·h^m-2 with an increase of 21.57% over the control was recorded in treatment 180 kg urea·h^m-2, which was statistically similar to treatment 90 kg urea·h^m-2. The prevalence of insects viz. green leafhopper, brown plant hopper, rice bugs, leaf folder and stem borers were mostly correlated with N-levels. The prevalence of insects in general gradu- ally increased with the increase of N. Therefore, this study suggests that the combined application of organic materials （tree litter of ipil-ipil） and N-fertilizer of 90 kg·h^m-2 may oroduce good yield while minimizine insect arevalence in the rice field.展开更多
The objective of this study is to identify system parameters from the recorded response of base isolated buildings,such as USC hospital building,during the 1994 Northridge earthquake.Full state measurements are not av...The objective of this study is to identify system parameters from the recorded response of base isolated buildings,such as USC hospital building,during the 1994 Northridge earthquake.Full state measurements are not available for identification.Additionally,the response is nonlinear due to the yielding of the lead-rubber bearings.Two new approaches are presented in this paper to solve the aforementioned problems.First,a reduced order observer is used to estimate the unmeasured states.Second,a least squares technique with time segments is developed to identify the piece-wise linear system properties.The observer is used to estimate the initial conditions needed for the time segmented identification.A series of equivalent linear system parameters are identified in different time segments.It is shown that the change in system parameters,such as frequencies and damping ratios,due to nonlinear behavior of the lead-rubber bearings,are reliably estimated using the presented technique.It is shown that the response was reduced due to yielding of the lead-rubber bearings and period lengthening.展开更多
An analytical solution for scattering of plane P waves by a semi-cylindrical hill was derived by using the wave function expansion method, and convergence of the solution and accuracy of truncation were verified. The ...An analytical solution for scattering of plane P waves by a semi-cylindrical hill was derived by using the wave function expansion method, and convergence of the solution and accuracy of truncation were verified. The effect of incident frequency and incident angle on the surface motion of the hill was discussed, and it was shown that a hill greatly amplifies incident plane P waves, and maximum horizontal displacement amplitudes appear mostly at the inclined incidence of waves, which are located at the half-space; and maximum vertical displacement amplitudes emerge mostly at the vertical incidence of waves, which are situated at the hill.展开更多
文摘In today’s world some changes have been occurred in human lifestyle,these changes,along with the advantages,have led to a series of disadvantages including their disconnection with the nature.One of the most important areas to re-establish the relationship is the school.The presence of nature at schools,and holding some classes in nature,in addition to meeting the special needs of children causes their separation from those small and boring classes as well as their interest in courses.This study aimed to investigate the role of nature in children’s learning.For this purpose,third,fourth and fifth grade classes of 3 schools were held outside the school environment and in the nature in 5 courses.The study is a combinational research and field,indirect observation and library data collection methods were applied,where in the indirect observation,two types of questionnaires were prepared related to the students and teachers and were randomly distributed among 580 students and 50 elementary school teachers.Test reliability was assessed using Cronbach’s alpha and it was obtained to be 0.890.The results of this study indicate that the physical place as one of the factors in children’s learning has the maximum impact on teaching and learning of children.At the end of the study and by investigating the existing factors in the environment we understood that the expansion of the nature and natural light of it causes the students’interest in lessons in nature.
基金supported by the Fundamental Research Program of Shanxi Province of China,No.20210302124277the Science Foundation of Shanxi Bethune Hospital,No.2021YJ13(both to JW)。
文摘Repetitive traumatic brain injury impacts adult neurogenesis in the hippocampal dentate gyrus,leading to long-term cognitive impairment.However,the mechanism underlying this neurogenesis impairment remains unknown.In this study,we established a male mouse model of repetitive traumatic brain injury and performed long-term evaluation of neurogenesis of the hippocampal dentate gyrus after repetitive traumatic brain injury.Our results showed that repetitive traumatic brain injury inhibited neural stem cell proliferation and development,delayed neuronal maturation,and reduced the complexity of neuronal dendrites and spines.Mice with repetitive traumatic brain injuryalso showed deficits in spatial memory retrieval.Moreover,following repetitive traumatic brain injury,neuroinflammation was enhanced in the neurogenesis microenvironment where C1q levels were increased,C1q binding protein levels were decreased,and canonical Wnt/β-catenin signaling was downregulated.An inhibitor of C1 reversed the long-term impairment of neurogenesis induced by repetitive traumatic brain injury and improved neurological function.These findings suggest that repetitive traumatic brain injury–induced C1-related inflammation impairs long-term neurogenesis in the dentate gyrus and contributes to spatial memory retrieval dysfunction.
文摘Background:Ferroptosis is a type of regulated cell death characterized by iron-dependent lipid peroxidation,which has been linked to tumor progression and therapeutic resistance.However,the contribution of lactate metabolism and its receptor,hydroxycarboxylic acid receptor 1(HCAR1),in ferroptosis regulation in gastric cancer(GC)remains poorly understood.Focusing specifically on its effects on cell proliferation,ferroptosis regulation,and the disruption of lactate-mediatedmetabolic pathways,the study aimed to clarify the role ofHCAR1 in GC progression.Methods:Bioinformatics analysis identified prognostic genes associated with ferroptosis in GC.Receiver operating characteristic(ROC)curves were generated to assess the diagnostic potential of the predictive genes.The biological role of HCAR1 was investigated through gain and loss-of-function experiments in GC cell lines,followed by assessments of cell viability,oxidative stress indicators,gene/protein expression,and ferroptosis sensitivity under lactate stimulation or HCAR1modulation.Results:HCAR1 was significantly upregulated in GC tissues and linked to poor patient outcomes.Silencing HCAR1 inhibited GC cell growth and induced ferroptosis,as shown by increased levels of reactive oxygen species(ROS)and malondialdehyde(MDA),along with decreased expression of solute carrier family 7 member 11(SLC7A11)and glutathione peroxidase 4(GPX4).Conversely,HCAR1 overexpression or exposure to extracellular lactate inhibited ferroptosis and activated antioxidant defenses.Mechanistically,lactate activation of HCAR1 increases ATP levels,which in turn inactivates AMP-activated protein kinase(AMPK).It also upregulates stearoyl-CoA desaturase 1(SCD1)through the sterol regulatory element binding protein 1(SREBP1)signaling pathway.Blocking HCAR1 reversed these effects and restored ferroptosis sensitivity.Conclusion:HCAR1 mediates lactate-driven ferroptosis resistance in GC through the AMPK-SCD1 signaling pathway.Targeting the HCAR1-lactate axis may offer a promising strategy for overcoming metabolic adaptation and improving GC treatment outcomes.
基金Supported by the Key Research and Development Program of Shaanxi Province,China,No.2021GXLH-Z-100.
文摘BACKGROUND Recurrence of common bile duct(CBD)calculi within 30 days following T-tube cholangiography is exceedingly rare.CASE SUMMARY This article details an instance of choledocholithiasis involving a 1.2 cm×0.9 cm stone located in the lower and middle segments of the CBD,identified 30 days after T-tube cholangiography,accompanied by multiple microstones.Magnetic resonance cholangiopancreatography revealed dilation of both intrahepatic and extrahepatic bile ducts,with the widest segment of the CBD measuring approximately 2 cm.The patient underwent laparoscopic choledochal exploration followed by choledochojejunostomy using the Roux-en-Y technique.CONCLUSION Although recurrence of choledocholithiasis within such a short postoperative period is exceedingly uncommon,this case underscores the necessity for clinicians to remain vigilant regarding the potential for early postoperative recurrence.
基金supported by the Aeronautical Science Foundation of China (20085584010)
文摘According to the characteristic of cruise missiles,navigation point setting is simplified,and the principle of route planning for saturation attack and a concept of reference route are put forward.With the help of the shortest-tangent idea in route-planning and the algorithm of back reasoning from targets,a reference route algorithm is built on the shortest range and threat avoidance.Then a route-flight-time algorithm is built on navigation points.Based on the conditions of multi-direction saturation attack,a route planning algorithm of multi-direction saturation attack is built on reference route,route-flight-time,and impact azimuth.Simulation results show that the algorithm can realize missiles fired in a salvo launch reaching the target simultaneously from different directions while avoiding threat.
基金National Natural Science Foundation of China(50378063)EYTP of MOESRF for ROCS,MOE
文摘A series solution of displacement response of the ground surface in the presence of underground twin tunnels subjected to excitation of incident plane SV waves is derived by using Fourier-Bessel series expansion method.The numerical parametric study shows that underground twin tunnels significantly amplify the nearby surface ground motion.It is suggested that the effect of subways on ground motion should be considered when the subways are planned and designed.
文摘Peripheral facial paralysis is a frequently encountered disease with a high incidence, and it is one of the most common diseases in acupuncture and moxibustion treatment. Because there are rich
基金Supported by Grant-in-Aid for H22-Third Term Comprehensive Control Research for Cancer 022 from the Japanese Ministry of Health,Labour and Welfare
文摘AIM:To investigate mortality reduction from gastric cancer based on the results of endoscopic screening.METHODS:The study population consisted of participants of gastric cancer screening by endoscopy,regular radiography,and photofluorography at Niigata city in 2005.The observed numbers of cumulative deaths from gastric cancers and other cancers were accumulated by linkage with the Niigata Prefectural Cancer Registry.The standardized mortality ratio(SMR)of gastric cancer and other cancer deaths in each screening group was calculated by applying the mortality rate of the reference population.RESULTS:Based on the results calculated from the mortality rate of the population of Niigata city,the SMRs of gastric cancer death were 0.43(95%CI:0.30-0.57)for the endoscopic screening group,0.68(95%CI:0.55-0.79)for the regular radiographic screening group,and 0.85(95%CI:0.71-0.94)for the photofluorography screening group.The mortality reduction from gastric cancer was higher in the endoscopic screening group than in the regular radiographic screening group despite the nearly equal mortality rates of all cancers except gastric cancer.CONCLUSION:The 57%mortality reduction from gastric cancer might indicate the effectiveness of endoscopic screening for gastric cancer.Further studies and prudent interpretation of results are needed.
基金Supported by the Infrastructure Supporting Project of Jiangxi Scientific Research Institute,No.20142BBA13039.
文摘BACKGROUND Reports in the field of robotic surgery for rectal cancer are increasing year by year.However,most of these studies enroll patients at a relatively early stage and have small sample sizes.In fact,studies only on patients with locally advanced rectal cancer(LARC)and with relatively large sample sizes are lacking.AIM To investigate whether the short-term outcomes differed between robotic-assisted proctectomy(RAP)and laparoscopic-assisted proctectomy(LAP)for LARC.METHODS The clinicopathological data of patients with LARC who underwent robotic-or laparoscopic-assisted radical surgery between January 2015 and October 2019 were collected retrospectively.To reduce patient selection bias,we used the clinical baseline characteristics of the two groups of patients as covariates for propensity-score matching(PSM)analysis.Short-term outcomes were compared between the two groups.RESULTS The clinical features were well matched in the PSM cohort.Compared with the LAP group,the RAP group had less intraoperative blood loss,lower volume of pelvic cavity drainage,less time to remove the pelvic drainage tube and urinary catheter,longer distal resection margin and lower rates of conversion(P<0.05).However,the time to recover bowel function,the harvested lymph nodes,the postoperative length of hospital stay,and the rate of unplanned readmission within 30 days postoperatively showed no difference between the two groups(P>0.05).The rates of total complications and all individual complications were similar between the RAP and LAP groups(P>0.05).CONCLUSION This retrospective study indicated that RAP is a safe and feasible method for LARC with better short-term outcomes than LAP,but we have to admit that the clinically significant of part of indicators are relatively small in the practical situation.
基金supported by the Directorate for Research and Community Service,University of Indonesia(RUUI Utama 2012),Jakarta,Indonesia
文摘The application of multi-hull ship or trimaran vessel as a mode of transports in both river and sea environments have grown rapidly in recent years.Trimaran vessels are currently of interest for many new high speed ship projects due to the high levels of hydrodynamic efficiency that can be achieved,compared to the mono-hull and catamaran hull forms.The purpose of this study is to identify the possible effects of using an unsymmetrical trimaran ship model with configuration（S/L） 0.1-0.3 and R/L=0.1-0.2.Unsymmetrical trimaran ship model with main dimensions： L=2000mm,B=200 mm and T=45 mm.Experimental methods（towing tank） were performed in the study using speed variations at Froude number 0.1-0.6.The ship model was pulled by an electric motor whose speed could be varied and adjusted.The ship model resistance was measured precisely by using a load cell transducer.The comparison of ship resistance for each configuration with mono-hull was shown on the graph as a function of the total resistance coefficient and Froude number.The test results found that the effective drag reduction could be achieved up to 17% at Fr=0.35 with configuration S/L=0.1.
基金Founded by National Natural Science Foundation of China(No.51004037)Shenyang City Application Basic Research Project(No.F13-316-1-15)State Key Laboratory Opening Project of Northeastern University(No.12SYS05)
文摘Continuous annealing simulation tests were conducted by using a continuous annealing thermomechanical simulator. Holding times of 5, 60, 180, and 480 seconds for an intercritical annealing temperature of 820℃ were adopted to investigate the evolution of the mierostructure and mechanical properties of ferrite-bainite dual-phase steel. The ferrite-bainite dual-phase steel was characterized by high strength and low yield ratio due to the presence of the constituents （polygonal ferrite, bainite, martensite and retained austenite） of the steel microstructure. Specimen 3 exhibits the highest value of A50 （7.67%） and a product of Rm × A50 （10453MPa%） after a 180s holding. This is likely attributed to the presence of a C-enriched retained anstenite in the microstructure. And the effect of martensite islands and carbide precipitate is thought to be able to contribute in strengthening the present steel. It is expected that equilibrium of anstenite fraction would be reached for reasonable intercritical holding period, regardless of the heating temperature. The results suggest that long increasing holding times may not be needed because the major phase of the microstructure does not change very significantly. It is favorable for industrial production of DP steels to shorten holding times. Key words： ferrite-bainite dual-phase steel; holding time; martensite islands; mechanical properties
基金supported by the National Natural Science Foundation of China(No.61273058)
文摘Accelerated degradation test is a useful approach to predict the product lifetime at the normal use stress level, especially for highly reliable products. Two kinds of the lifetime prediction based on Gamma processes were studied. One was to predict the lifetime of the population from accelerated degradation data, and the other was to predict the lifetime of an individual by taking the accelerated degradation data as prior information. For an extensive application, the Gamma process with a time transformation and random effects was considered. A novel contribution is that a deducing method for determining the relationships between the shape and scale parameters of Gamma processes and accelerated stresses was presented. When predicting the lifetime of an individual, Bayesian inference methods were adopted to improve the prediction accuracy, in which the conjugate prior distribution and the non-conjugate prior distribution of random parameters were studied. The conjugate prior distribution only considers the random effect of the scale parameter while the non-conjugate prior distribution considers the random effects of both the scale and shape parameter. The application and usefulness of the proposed method was demonstrated by the accelerated degradation data of carbon-film resistors.
文摘The shrinkage and chilling tendency of spheroidal graphite (abbreviated SG) cast iron is much greater than that of the flake graphite cast iron in spite of its higher amount of C and Si contents. Why? The main reason should be the difference in their graphitization during the eutectic solidification. In this paper, we discuss the difference in the solidification mechanism of both cast irons for solving these problems using unidirectional solidification and the cooling curves of the spheroidal graphite cast iron. The eutectic solidification rate of the SG cast iron is controlled by the diffusion of carbon through the austenite shell, and the final thickness is 1.4 times the radius of the SG, therefore, the reduction of the SG size, namely, the increase in the number, is the main solution of these problems.
基金This study was supported by"333 Talent Project " funds of Jiangsu Province in 1999.
文摘Objective. To investigate the relationship of plasma homocysteine (Hcy) level to stroke and genetic factor to elevated plasma Hcy level.Methods. The plasma Hcy level was measured by capillary electrophoresis- ultraviolet detection and the gene polymorphism of N5, N10 - methylenetetrahydrofolate reductase (MTHFR) was studied with PCR - RFLP assay in 43 patients with cortical cerebral infarction and 42 healthy controls.Results. The plasma Hcy level of the patients ( 19. 3 + 6. 0 μ mol/L) was markedly higher than that of the controls (13.7 + 5.4 μ mol/L) ( t = 4. 16, P ＜ 0. 001). There are 3 genotypes, C/C, C/T and T/T, about base - variation of MTHFR gene at locus 677. The plasma Hcy level of the subjects with T/T genotype was higher than that of subjects with other genotypes. However, the frequencies of each genotype and allele were not significantly different between the patients and the controls.Conclusions. The elevated plasma Hcy level is a risk factor for atherothrombotic cerebral infarction, and is related to the C→T mutation at locus 677 of MTHFR gene.
文摘A novel time-domain identification technique is developed for the seismic response analysis of soil-structure interaction.A two-degree-of-freedom (2DOF) model with eight lumped parameters is adopted to model the frequency- dependent behavior of soils.For layered soil,the equivalent eight parameters of the 2DOF model are identified by the extended Kalman filter (EKF) method using recorded seismic data.The polynomial approximations for derivation of state estimators are applied in the EKF procedure.A realistic identification example is given for the layered-soil of a building site in Anchorage,Alaska in the United States.Results of the example demonstrate the feasibility and practicality of the proposed identification technique.The 2DOF soil model and the identification technique can be used for nonlinear response analysis of soil-structure interaction in the time-domain for layered or complex soil conditions.The identified parameters can be stored in a database tor use in other similar soil conditions,lfa universal database that covers information related to most soil conditions is developed in the thture,engineers could conveniently perform time history analyses of soil-structural interaction.
文摘Objective:To observe changes in the molecular expression of the NLR Family Pyrin Domain Containing Protein 3(NLRP3)pathway in depressed rats after treatment with Xiaoyaosan,and identify the regulatory mechanism of this compound.Methods:Male SpragueeD awley rats were randomly divided into five groups with 12 rats in each group,including the control group,model group,Fluoxetine group,Xiaoyaosan group,and MCC950 group.A depression model was generated by chronic immobilization stress(induced by 3 h of restraint immobilization every day),and the drugs were administered at the same time in each group for 21 days.The effects of Xiaoyaosan on behavioral changes of depressed rats were observed through macroscopic characterization,body mass,open field experiments,and a sucrose preference test.The m RNA and protein expression of the NLRP3 signaling pathway was examined by fluorescence real-time quantitative PCR and Western blot assays.Results:The Xiaoyaosan group,Fluoxetine group,and MCC950 group rats showed improved depressive behavior and an increased weight of sucrose water consumption.The protein and mRNA expression levels of NLRP3,Caspase-1,and IL-1 b were also decreased in the Fluoxetine,Xiaoyaosan,and MCC950 groups.Conclusion:NLRP3,Caspase-1,and IL-1 b protein and mRNA expression levels were increased in the cortex of depressed rats,while Xiaoyaosan protected cortical tissue in these rats by decreasing NLRP3,Caspase-1,and IL-1 b protein and mRNA expression.
文摘The present study was undertaken to determine the effects of different levels of urea-N fertilizer in addition to ipil-ipil tree litter on yield of rice and insect prevalence. The field study was conducted at the Agroforestry Field Laboratory, Bangladesh Agricultural University, Mymensingh during July-December 2004. The treatments included 0, 90, 180, and 270 kg urea per hectare. All four treatments received five tons ipil-ipil tree litter per hectare. The experiment was laid out in a randomized complete block design （RCBD） with four replications. The results showed that the different treatments significantly influenced the yield and yield component viz. total tillers/hill, effective tillers/hill, filled grains and unfilled grains/panicle. The highest yield of 4.62 t·h^m-2 with an increase of 21.57% over the control was recorded in treatment 180 kg urea·h^m-2, which was statistically similar to treatment 90 kg urea·h^m-2. The prevalence of insects viz. green leafhopper, brown plant hopper, rice bugs, leaf folder and stem borers were mostly correlated with N-levels. The prevalence of insects in general gradu- ally increased with the increase of N. Therefore, this study suggests that the combined application of organic materials （tree litter of ipil-ipil） and N-fertilizer of 90 kg·h^m-2 may oroduce good yield while minimizine insect arevalence in the rice field.
文摘The objective of this study is to identify system parameters from the recorded response of base isolated buildings,such as USC hospital building,during the 1994 Northridge earthquake.Full state measurements are not available for identification.Additionally,the response is nonlinear due to the yielding of the lead-rubber bearings.Two new approaches are presented in this paper to solve the aforementioned problems.First,a reduced order observer is used to estimate the unmeasured states.Second,a least squares technique with time segments is developed to identify the piece-wise linear system properties.The observer is used to estimate the initial conditions needed for the time segmented identification.A series of equivalent linear system parameters are identified in different time segments.It is shown that the change in system parameters,such as frequencies and damping ratios,due to nonlinear behavior of the lead-rubber bearings,are reliably estimated using the presented technique.It is shown that the response was reduced due to yielding of the lead-rubber bearings and period lengthening.
基金National Natural Science Foundation of China Under Grant No.50378063Excellent Young Teacher Program of Ministry of Education
文摘An analytical solution for scattering of plane P waves by a semi-cylindrical hill was derived by using the wave function expansion method, and convergence of the solution and accuracy of truncation were verified. The effect of incident frequency and incident angle on the surface motion of the hill was discussed, and it was shown that a hill greatly amplifies incident plane P waves, and maximum horizontal displacement amplitudes appear mostly at the inclined incidence of waves, which are located at the half-space; and maximum vertical displacement amplitudes emerge mostly at the vertical incidence of waves, which are situated at the hill.
