Laminated elastomeric bearings used in seismic isolation rely on the mechanical properties of their constituent elastomers to ensure effective performance.However,despite their resistance to temperature fluctuations a...Laminated elastomeric bearings used in seismic isolation rely on the mechanical properties of their constituent elastomers to ensure effective performance.However,despite their resistance to temperature fluctuations and environmental aggressors,silicone elastomers exhibit relatively low stiffness,limiting their direct applicability in seismic isolation.This study investigates the effect of fumed silica as a reinforcing filler to enhance the mechanical properties of laminated silicone elastomeric bearings.Elastomeric samples were fabricated with varying fumed silica proportions and subjected to Shore A hardness,uniaxial tensile,and lap shear tests to assess the influence of filler content.Additionally,quasi-static tests were conducted on reduced-scale bearing prototypes under combined vertical compression and cyclic horizontal shear to evaluate their seismic isolation performance.The results demonstrate that fumed silica reinforcement significantly increases stiffness,as evidenced by higher Shore A hardness values.However,a trade-off was observed in tensile properties,with reductions in tensile strength and elongation at break.Despite this,the equivalent elastic modulus did not show substantial variation up to large deformations,indicating that stiffness is preserved under most working conditions.Lap shear tests showed that fumed silica improves shear resistance,while quasi-static tests revealed inelastic behavior with small increases in equivalent shear coefficients but no substantial loss in damping ratios.These findings suggest that fumed silica reinforcement enhances silicone elastomers’stiffness and shear resistance while maintaining moderate damping properties,making it a promising approach for improving the mechanical performance of elastomeric bearings in seismic isolation applications.展开更多
The chemo-,regio-,and enantio-controlled synthesis of P-chiral phosphines in a general and efficient manner remains a significant synthetic challenge.In this study,a Pd-catalyzed hydrofunctionalization is developed fo...The chemo-,regio-,and enantio-controlled synthesis of P-chiral phosphines in a general and efficient manner remains a significant synthetic challenge.In this study,a Pd-catalyzed hydrofunctionalization is developed for the highly selective synthesis of P-stereogenic alkenylphosphinates and alkenylphosphine oxides via conjugate addition of enynes.Notably,this methodology is suitable for both phosphine oxide and phosphinate nucleophiles,providing a versatile approach for the construction of diverse P-chiral organophosphosphorus compound.展开更多
In this paper, we propose a novel method using artificial neural networks(ANNs) to reconstruct the global 21 cm signal from measurements of the 21 cm power spectrum. The 21 cm global signal provides crucial informatio...In this paper, we propose a novel method using artificial neural networks(ANNs) to reconstruct the global 21 cm signal from measurements of the 21 cm power spectrum. The 21 cm global signal provides crucial information on cosmic evolution from the Dark Ages through cosmic dawn and the Epoch of Reionization. Single-dish telescopes directly measure the global signal, whereas interferometric experiments primarily measure spatial fluctuations,represented by the 21 cm power spectrum. While no direct mathematical relationship exists between these two observables-since they probe fundamentally independent Fourier modes-they are indirectly linked through their common dependence on underlying astrophysical and cosmological parameters. The ANN effectively learns this implicit, model-dependent relationship, enabling it to predict the global signal from the power spectrum. We demonstrate that the ANN accurately recovers the global 21 cm signal across a broad redshift range(z = 7.5–35)even under realistic observational noise scenarios corresponding to SKA-1 observations. The reconstruction accuracy depends significantly on the spatial scales(wavenumber k) included, with larger-scale modes yielding better results due to their stronger sensitivity to global astrophysical processes. Although the ANN method does not provide a model-independent verification of anomalous observations(e.g., the Experiment to Detect the Global Epoch of Reionization Signature absorption trough), it offers a computationally efficient and robust tool to infer the global signal within the context of standard astrophysical and cosmological models.展开更多
Dietary specialists consume specific prey items,and they are often morphologically and behaviorally specialized to feed efficiently on those prey animals.Among specialist snakes,consumption of terrestrial arthropods i...Dietary specialists consume specific prey items,and they are often morphologically and behaviorally specialized to feed efficiently on those prey animals.Among specialist snakes,consumption of terrestrial arthropods is relatively rare.Because most terrestrial arthropods possess hardened sclerites and appendages,it is possible that snakes that feed on arthropods would show specialized prey-handling behavior.In this study,we describe prey-handling behavior of a snake feeding on terrestrial arthropods,which hitherto has not been well documented.We focused on Rhabdophis chiwen,which mainly feeds on earthworms,but also consumes lampyrine firefly larvae,sequestering cardiotonic steroids from them in its defensive organs,called nucho-dorsal glands.When feeding on earthworms,snakes showed size-dependent selection of swallowing direction,but this tendency was not observed when feeding on firefly larvae.Manipulation of firefly larvae did not seem to be efficient,probably because they possess sclerites and appendages such as legs that impede smooth handling.Although fireflies are an essential food for R.chiwen as a toxin source,our results showed that the snake is not adept at handling firefly larvae compared to earthworms,implying that dietary specialization does not necessarily accompany behavioral specialization.We discuss possible reasons for this inconsistency.展开更多
Flight feathers represent a hallmark innovation of avian evolution.Recent comparative genomic analyses identified a 284 bp avian-specific highly conserved element(ASHCE)located within the eighth intron of the SIM bHLH...Flight feathers represent a hallmark innovation of avian evolution.Recent comparative genomic analyses identified a 284 bp avian-specific highly conserved element(ASHCE)located within the eighth intron of the SIM bHLH transcription factor 1(Sim1)gene,postulated to act as a cis-regulatory element governing flight feather morphogenesis.To investigate its functional significance,genome-edited(GE)primordial germ cell(PGC)lines carrying targeted ASHCE deletions were generated using CRISPR/Cas9-mediated editing,with germline chimeric males subsequently mated with wild-type(WT)hens to obtain GE progeny.The resulting GE chickens harbored 257-260 bp deletions,excising approximately half of the Sim1-ASHCE sequence.Reverse transcription-quantitative real-time polymerase chain reaction(RT-qPCR)analysis showed an average 0.32-fold reduction in Sim1 expression in the forelimbs of GE embryos at day 8(E8)compared to WT counterparts.Despite this,GE chickens developed structurally normal flight and tail feathers.In situ hybridization localized Sim1 expression to the posterior mesenchyme surrounding flight feather buds in E8 WT embryos,but not within the buds themselves.These results suggest that partial deletion of Sim1-ASHCE,despite diminishing Sim1 expression,does not disrupt flight feather formation.The excised region appears to possess enhancer activity toward Sim1 but is dispensable for flight feather development.Complete ablation of the ASHCE will be necessary to fully resolve the regulatory role of Sim1 in avian feather morphogenesis.展开更多
The discontinuation of denosumab[antibody targeting receptor activator of nuclear factor kappa B ligand(RANKL)]therapy may increase the risk of multiple vertebral fractures;however,the underlying pathophysiology is la...The discontinuation of denosumab[antibody targeting receptor activator of nuclear factor kappa B ligand(RANKL)]therapy may increase the risk of multiple vertebral fractures;however,the underlying pathophysiology is largely unknown.In patients who underwent discontinuation after multiple injections of denosumab,the levels of tartrate-resistant acid phosphatase 5b increased compared to pretreatment levels,indicating a phenomenon known as“overshoot.”The rate of decrease in bone mineral density during the withdrawal period was higher than the rate of decrease associated with aging,suggesting that the physiological bone metabolism had broken down.Overshoot and significant bone loss were also observed in mice receiving continuous administration of anti-RANKL antibody after treatment was interrupted,resembling the original pathology.In mice long out of overshoot,bone resorption recovered,but osteoblast numbers and bone formation remained markedly reduced.The bone marrow exhibited a significant reduction in stem cell(SC)antigen 1-and platelet-derived growth factor receptor alpha-expressing osteoblast progenitors(PαS cells)and alkaline phosphatase-positive early osteoblasts.Just before the overshoot phase,the osteoclast precursor cell population expands and RANKL-bearing extracellular vesicles(EVs)became abundant in the serum,leading to robust osteoclastogenesis after cessation of anti-RANKL treatment.Thus,accelerated bone resorption due to the accumulation of RANKLbearing EVs and long-term suppression of bone formation uncoupled from bone resorption leads to the severe bone loss characteristic of denosumab discontinuation.展开更多
To comprehensively understand the Arctic and Antarctic upper atmosphere, it is often crucial to analyze various data that are obtained from many regions. Infrastructure that promotes such interdisciplinary studies on ...To comprehensively understand the Arctic and Antarctic upper atmosphere, it is often crucial to analyze various data that are obtained from many regions. Infrastructure that promotes such interdisciplinary studies on the upper atmosphere has been developed by a Japanese inter-university project called the Inter-university Upper atmosphere Global Observation Network （1UGONET）. The objective of this paper is to describe the infrastructure and tools developed by IUGONET. We focus on the data analysis software. It is written in Interactive Data Language （IDL） and is a plug-in for the THEMIS Data Analysis Software suite （TDAS）, which is a set of IDL libraries used to visualize and analyze satellite- and ground-based data. We present plots of upper atmospheric data provided by IUGONET as examples of applications, and verify the usefulness of the software in the study of polar science. We discuss IUGONET＇s new and unique developments, i.e., an executable file of TDAS that can run on the IDL Virtual Machine, IDL routines to retrieve metadata from the IUGONET database, and an archive of 3-D simulation data that uses the Common Data Format so that it can easily be used with TDAS.展开更多
Amorphous high-entropy materials with abundant defects,coordinatively unsaturated sites,and loosely bonded atoms could exhibit excellent electrocatalytic performance.However,how to fabricate such ma-terials with nanos...Amorphous high-entropy materials with abundant defects,coordinatively unsaturated sites,and loosely bonded atoms could exhibit excellent electrocatalytic performance.However,how to fabricate such ma-terials with nanostructure as well as amorphous structure is still full of challenges.In this work,high-entropy metal organic framework(HE-MOF)is employed as the self-sacrificial template to fabricate FeCoNiCuMnP x high-entropy phosphide/carbon(HEP/C)composites.The obtained composite shows a het-erostructured fusiform morphology,in which the HEP is encapsulated by a carbon layer,revealing high electron conductivity as well as rich catalytic active sites for oxygen evolution reaction(OER).Beside,it is found that there is a short-range ordered crystal structure in the amorphous phase,which is bene-ficial for revealing high OER catalytic activity as well as good stability.As a result,the optimum HEP/C composite shows an overpotential 239 mV@10 mA cm^(−2)with a small Tafel slope of 72.5 mV dec^(−1) for catalyzing OER in alkaline solution.展开更多
Since the 1950s,when the Turing Test was introduced,there has been notable progress in machine language intelligence.Language modeling,crucial for AI development,has evolved from statistical to neural models over the ...Since the 1950s,when the Turing Test was introduced,there has been notable progress in machine language intelligence.Language modeling,crucial for AI development,has evolved from statistical to neural models over the last two decades.Recently,transformer-based Pre-trained Language Models(PLM)have excelled in Natural Language Processing(NLP)tasks by leveraging large-scale training corpora.Increasing the scale of these models enhances performance significantly,introducing abilities like context learning that smaller models lack.The advancement in Large Language Models,exemplified by the development of ChatGPT,has made significant impacts both academically and industrially,capturing widespread societal interest.This survey provides an overview of the development and prospects from Large Language Models(LLM)to Large Multimodal Models(LMM).It first discusses the contributions and technological advancements of LLMs in the field of natural language processing,especially in text generation and language understanding.Then,it turns to the discussion of LMMs,which integrates various data modalities such as text,images,and sound,demonstrating advanced capabilities in understanding and generating cross-modal content,paving new pathways for the adaptability and flexibility of AI systems.Finally,the survey highlights the prospects of LMMs in terms of technological development and application potential,while also pointing out challenges in data integration,cross-modal understanding accuracy,providing a comprehensive perspective on the latest developments in this field.展开更多
Dynamic transformation(DT)of austenite(γ)to ferrite(α)in the hot deformation of various carbon steels was widely investigated.However,the nature of DT remains unclear due to the lack of quantitative analysis of stre...Dynamic transformation(DT)of austenite(γ)to ferrite(α)in the hot deformation of various carbon steels was widely investigated.However,the nature of DT remains unclear due to the lack of quantitative analysis of stress partitioning between two phases and the uncertainty of local distribution of substitu-tional elements at the interface in multi-component carbon steels used in the previous studies.Therefore,in the present study,a binary Fe-Ni alloy withα+γduplex microstructure in equilibrium was prepared and isothermally compressed inα+γtwo-phase region to achieve a quantitative analysis of microstruc-ture evolution,stress partitioning,and thermodynamics during DT.γtoαDT during isothermal compres-sion andαtoγreverse transformation on isothermal annealing under unloaded condition after deforma-tion were accompanied by Ni partitioning.The lattice strains during thermomechanical processing were obtained via in-situ neutron diffraction measurement,based on which the stress partitioning behavior betweenγandαwas discussed by using the generalized Hooke’s law.A thermodynamic framework for the isothermal deformation in solids was established based on the basic laws of thermodynamics,and it was shown that the total Helmholtz free energy change in the deformable material during the isothermal process should be smaller than the work done to the deformable material.Under the present thermody-namic framework,the microstructure evolution in the isothermal compression of Fe-14Ni alloy was well explained by considering the changes in chemical free energy,plastic and elastic energies,and the work done to the material.In addition,the stabilization of the softαphase in Fe-14Ni alloy by deformation was rationalized since theγtoαtransformation decreased the total Helmholtz free energy by decreasing the elastic and dislocation energies.展开更多
The Arun and Tista Rivers,which flow across the Himalayas,are commonly known as antecedent valleys that overcame the rapid uplift of the Higher Himalayan ranges.To clarify whether the idea of antecedent rivers is acce...The Arun and Tista Rivers,which flow across the Himalayas,are commonly known as antecedent valleys that overcame the rapid uplift of the Higher Himalayan ranges.To clarify whether the idea of antecedent rivers is acceptable,we investigated the geomorphology of the Himalayas between eastern Nepal and Bhutan Himalayas.The southern part of Tibetan Plateau,extending across the Himalayas as tectonically un-deformed glaciated terrain named as'Tibetan Corridor,'does not suggest the regional uplift of the Higher Himalayas.The 8,000-m class mountains of Everest,Makalu,and Kanchenjunga are isolated residual peaks on the glaciated terrain composed of mountain peaks of 4,000–6,000 m high.The Tibetan glaciers commonly beheaded by Himalayan glaciers along the great watershed of the Himalayas suggest the expansion of Himalayan river drainage by glaciation.For the narrow upstream regions of the Arun and Tista Rivers with less precipitation behind the range,it is hard to collect enough water for the power of down-cutting their channels against the uplifting Himalayas.The fission track ages of the Higher Himalayan Crystalline Nappe suggest that the Himalayas attained their present altitude by 11–10 Ma,and the Arun and Tista Rivers formed deep gorges across the Himalayas by headward erosion.展开更多
The fracture toughness of extruded Mg-1Zn-2Y(at.%)alloys,featuring a multimodal microstructure containing fine dynamically recrystallized(DRXed)grains with random crystallographic orientation and coarse-worked grains ...The fracture toughness of extruded Mg-1Zn-2Y(at.%)alloys,featuring a multimodal microstructure containing fine dynamically recrystallized(DRXed)grains with random crystallographic orientation and coarse-worked grains with a strong fiber texture,was investigated.The DRXed grains comprised randomly oriented equiaxedα-Mg grains.In contrast,the worked grains includedα-Mg and long-period stacking ordered(LPSO)phases that extended in the extrusion direction(ED).Both types displayed a strong texture,aligning the(10.10)direction parallel to the ED.The volume fractions of the DRXed and worked grains were controlled by adjusting the extrusion temperature.In the longitudinal-transverse(L-T)orientation,where the loading direction was aligned parallel to the ED,there was a tendency for the conditional fracture toughness,KQ,tended to increase as the volume fraction of the worked grains increased.However,the KQ values in the T-L orientation,where the loading direction was perpendicular to the ED,decreased with an increase in the volume fraction of the worked grains.This suggests strong anisotropy in the fracture toughness of the specimen with a high volume fraction of the worked grains,relative to the test direction.The worked grains,which included the LPSO phase and were elongated perpendicular to the initial crack plane,suppressed the straight crack extension,causing crack deflection,and generating secondary cracks.Thus,these worked grains significantly contributed to the fracture toughness of the extruded Mg-1Zn-2Y alloys in the L-T orientation.展开更多
Visualization experiments were conducted to clarify the operational characteristics of a polymer pulsating heat pipe(PHP).Hydrofluoroether(HFE)-7100 was used as a working fluid,and its filling ratio was 50%of the enti...Visualization experiments were conducted to clarify the operational characteristics of a polymer pulsating heat pipe(PHP).Hydrofluoroether(HFE)-7100 was used as a working fluid,and its filling ratio was 50%of the entire PHP channel.A semi-transparent PHP was fabricated using a transparent polycarbonate sheet and a plastic 3D printer,and the movements of liquid slugs and vapor plugs of the working fluid were captured with a high-speed camera.The video images were then analyzed to obtain the flow patterns in the PHP.The heat transfer characteristics of the PHPwere discussed based on the flowpatterns and temperature distributions obtainedwith thermocouples.Before starting heating,because of high wettability,large liquid slugs positioned at the evaporator section of the PHP.After starting heating,since the occurrence of boiling divided the large liquid slugs,oscillatory flowof smaller liquid slugs and vapor plugs was found in the PHP.Clear circulation flow of liquid slugs and vapor plugs was observed when the power input to the PHP was larger than 12.0 W.The flow patterns and temperature distributions confirmed that the circulation flow enhanced the heat transfer from the evaporator section to the condenser section of the PHP.In the circulation flow mode,large growth and contraction of vapor plugs were found one after another in all even-numbered PHP channels.However,the analysis of flow patterns clarified that the phase-change heat transfer rate by large growth and contraction of vapor plugs was 19%of the total heat transfer rate of the PHP.Although the generation of large vapor plugs was found in the PHP,most of the heat was transferred by the sensible heat of the working fluid.展开更多
GHz burst-mode femtosecond(fs)laser,which emits a series of pulse trains with extremely short intervals of several hundred picoseconds,provides distinct characteristics in materials processing as compared with the con...GHz burst-mode femtosecond(fs)laser,which emits a series of pulse trains with extremely short intervals of several hundred picoseconds,provides distinct characteristics in materials processing as compared with the conventional irradiation scheme of fs laser(single-pulse mode).In this paper,we take advantage of the moderate pulse interval of 205 ps(4.88 GHz)in the burst pulse for high-quality and high-efficiency micromachining of single crystalline sapphire by laser induced plasma assisted ablation(LIPAA).Specifically,the preceding pulses in the burst generate plasma by ablation of copper placed behind the sapphire substrate,which interacts with the subsequent pulses to induce ablation at the rear surface of sapphire substrates.As a result,not only the ablation quality but also the ablation efficiency and the fabrication resolution are greatly improved compared to the other schemes including single-pulse mode fs laser direct ablation,single-pulse mode fs-LIPAA,and nanosecond-LIPAA.展开更多
This study aims to investigate the extrusion temperature effects on the development of heterogeneous microstructures and mechanical properties,focusing on their impact on the fracture toughness of AZ31B alloys.Magnesi...This study aims to investigate the extrusion temperature effects on the development of heterogeneous microstructures and mechanical properties,focusing on their impact on the fracture toughness of AZ31B alloys.Magnesium AZ31B(Mg-3wt%Al-1wt%Zn)alloys with high strength and reasonable fracture toughness,featuring heterogeneous microstructures,were fabricated via warm/hot extrusion at temperatures ranging from 523 to 723 K.The AZ31B alloy extruded at 523 K was bimodally grained into coarse worked grains with high Kernel average misorientation(KAM)values and fine dynamically recrystallized(DRXed)grains(<10μm)with intermediate KAM values.The 523 K-extruded alloy exhibited a high tensile yield strength of∼280 MPa and fracture toughness KJIC of∼26 MPa·m^(1/2).Conversely,the 723 K-extruded AZ31B alloy was trimodally grained into a small amount of worked grains,fine DRXed grains,and coarse DRXed grains(>10μm)with low KAM values.The 723 K-extruded alloy exhibited low tensile yield strength but a high KJIC value of∼36 MPa·m^(1/2)owing to the high energy dissipation for crack extension in the coarse DRXed grains.展开更多
A series of undrained triaxial tests was conducted to investigate the effect of crushed mudstone with the immersion-induced degradation on the liquefaction and post-liquefaction properties,and the undrained shearing b...A series of undrained triaxial tests was conducted to investigate the effect of crushed mudstone with the immersion-induced degradation on the liquefaction and post-liquefaction properties,and the undrained shearing behavior without precedent cyclic-loading histories of sands containing crushed mudstone.The tested materials with a main particle diameter of 2-0.85 mm were prepared by mixing sands and crushed mudstone to reach the prescribed mudstone content defined by dry mass ranging from 0% to 50%.The mixtures were subjected to immersion under a certain stress level and were subsequently tested.In addition,one-dimensional compression tests were also supplementally performed to visually observe the immersion-induced degradation of crushed mudstone.The test results mainly showed that: (1) the liquefaction resistance,the post-liquefaction undrained strength,and the undrained strength without a precedent cyclic-loading history decreased significantly with increasing mudstone content,M c ,up to 20%;(2) even a small amount of crushed mudstone affected these strengths;(3) the above-mentioned large reductions in the strengths were attributed to the immersion-induced degradation of crushed mudstone;(4) at M_(c) >20%,the liquefaction resistance increased while the significant increase in the undrained static strengths with and without precedent cyclic-loading histories was not observed;and (5) the increase in the liquefaction resistance at M_(c) >20% may have been attributed to both the gradual increase in the plasticity and the formation of the soil aggregates among deteriorated crushed mudstone,while the increase in the specimen density did not play an important role in such behavior.展开更多
Mg_(97)Zn_(1)Y_(2)alloys with high ignition temperatures were developed by adding Sr.The addition of Sr resulted in the formation of a uniform and thin Y_(2)O_(3)film.Mg–Zn–Y alloys containing at least 0.25 at.%Sr e...Mg_(97)Zn_(1)Y_(2)alloys with high ignition temperatures were developed by adding Sr.The addition of Sr resulted in the formation of a uniform and thin Y_(2)O_(3)film.Mg–Zn–Y alloys containing at least 0.25 at.%Sr exhibited ignition temperatures of 1270–1320 K.As a result of EDS measurement,Sr was found to be concentrated in the Y_(2)O_(3)film.In addition,a mixed film of MgO and Sr O formed on the outer layer in the 1.5 at.%Sr-containing Mg_(97)Zn_(1)Y_(2)alloy.These findings suggest that the uniform and thin Y_(2)O_(3)film that maintains high soundness at high temperatures was formed owing to valence control and the formation of a protective outer oxide film.展开更多
This study explores the impact of hyperparameter optimization on machine learning models for predicting cardiovascular disease using data from an IoST(Internet of Sensing Things)device.Ten distinct machine learning ap...This study explores the impact of hyperparameter optimization on machine learning models for predicting cardiovascular disease using data from an IoST(Internet of Sensing Things)device.Ten distinct machine learning approaches were implemented and systematically evaluated before and after hyperparameter tuning.Significant improvements were observed across various models,with SVM and Neural Networks consistently showing enhanced performance metrics such as F1-Score,recall,and precision.The study underscores the critical role of tailored hyperparameter tuning in optimizing these models,revealing diverse outcomes among algorithms.Decision Trees and Random Forests exhibited stable performance throughout the evaluation.While enhancing accuracy,hyperparameter optimization also led to increased execution time.Visual representations and comprehensive results support the findings,confirming the hypothesis that optimizing parameters can effectively enhance predictive capabilities in cardiovascular disease.This research contributes to advancing the understanding and application of machine learning in healthcare,particularly in improving predictive accuracy for cardiovascular disease management and intervention strategies.展开更多
文摘Laminated elastomeric bearings used in seismic isolation rely on the mechanical properties of their constituent elastomers to ensure effective performance.However,despite their resistance to temperature fluctuations and environmental aggressors,silicone elastomers exhibit relatively low stiffness,limiting their direct applicability in seismic isolation.This study investigates the effect of fumed silica as a reinforcing filler to enhance the mechanical properties of laminated silicone elastomeric bearings.Elastomeric samples were fabricated with varying fumed silica proportions and subjected to Shore A hardness,uniaxial tensile,and lap shear tests to assess the influence of filler content.Additionally,quasi-static tests were conducted on reduced-scale bearing prototypes under combined vertical compression and cyclic horizontal shear to evaluate their seismic isolation performance.The results demonstrate that fumed silica reinforcement significantly increases stiffness,as evidenced by higher Shore A hardness values.However,a trade-off was observed in tensile properties,with reductions in tensile strength and elongation at break.Despite this,the equivalent elastic modulus did not show substantial variation up to large deformations,indicating that stiffness is preserved under most working conditions.Lap shear tests showed that fumed silica improves shear resistance,while quasi-static tests revealed inelastic behavior with small increases in equivalent shear coefficients but no substantial loss in damping ratios.These findings suggest that fumed silica reinforcement enhances silicone elastomers’stiffness and shear resistance while maintaining moderate damping properties,making it a promising approach for improving the mechanical performance of elastomeric bearings in seismic isolation applications.
基金the National Natural Science Foundation of China(NSFC,No.22271241),Yunnan Key Laboratory of Chiral Functional Substance Research and Application(No.202402AN360010)Research Grants Council of Hong Kong(GRF,No.12303422)HKBU KRPS grant for financial support.
文摘The chemo-,regio-,and enantio-controlled synthesis of P-chiral phosphines in a general and efficient manner remains a significant synthetic challenge.In this study,a Pd-catalyzed hydrofunctionalization is developed for the highly selective synthesis of P-stereogenic alkenylphosphinates and alkenylphosphine oxides via conjugate addition of enynes.Notably,this methodology is suitable for both phosphine oxide and phosphinate nucleophiles,providing a versatile approach for the construction of diverse P-chiral organophosphosphorus compound.
基金supported by the National SKA Program of China(No.2020SKA0110401)the National Natural Science Foundation of China(NSFC,grant No.12103044).
文摘In this paper, we propose a novel method using artificial neural networks(ANNs) to reconstruct the global 21 cm signal from measurements of the 21 cm power spectrum. The 21 cm global signal provides crucial information on cosmic evolution from the Dark Ages through cosmic dawn and the Epoch of Reionization. Single-dish telescopes directly measure the global signal, whereas interferometric experiments primarily measure spatial fluctuations,represented by the 21 cm power spectrum. While no direct mathematical relationship exists between these two observables-since they probe fundamentally independent Fourier modes-they are indirectly linked through their common dependence on underlying astrophysical and cosmological parameters. The ANN effectively learns this implicit, model-dependent relationship, enabling it to predict the global signal from the power spectrum. We demonstrate that the ANN accurately recovers the global 21 cm signal across a broad redshift range(z = 7.5–35)even under realistic observational noise scenarios corresponding to SKA-1 observations. The reconstruction accuracy depends significantly on the spatial scales(wavenumber k) included, with larger-scale modes yielding better results due to their stronger sensitivity to global astrophysical processes. Although the ANN method does not provide a model-independent verification of anomalous observations(e.g., the Experiment to Detect the Global Epoch of Reionization Signature absorption trough), it offers a computationally efficient and robust tool to infer the global signal within the context of standard astrophysical and cosmological models.
基金supported in part by JST SPRING(JPMJSP2110)by Japan Society for the Promotion of Science Grants-in-Aid for Scientific Research(18KK0205,21H02551)Shosuke Takeuchi for personal funding.
文摘Dietary specialists consume specific prey items,and they are often morphologically and behaviorally specialized to feed efficiently on those prey animals.Among specialist snakes,consumption of terrestrial arthropods is relatively rare.Because most terrestrial arthropods possess hardened sclerites and appendages,it is possible that snakes that feed on arthropods would show specialized prey-handling behavior.In this study,we describe prey-handling behavior of a snake feeding on terrestrial arthropods,which hitherto has not been well documented.We focused on Rhabdophis chiwen,which mainly feeds on earthworms,but also consumes lampyrine firefly larvae,sequestering cardiotonic steroids from them in its defensive organs,called nucho-dorsal glands.When feeding on earthworms,snakes showed size-dependent selection of swallowing direction,but this tendency was not observed when feeding on firefly larvae.Manipulation of firefly larvae did not seem to be efficient,probably because they possess sclerites and appendages such as legs that impede smooth handling.Although fireflies are an essential food for R.chiwen as a toxin source,our results showed that the snake is not adept at handling firefly larvae compared to earthworms,implying that dietary specialization does not necessarily accompany behavioral specialization.We discuss possible reasons for this inconsistency.
基金supported by the Ministry of Agriculture and Rural Affairs of the People's Republic of China(125A0607)Department of Science and Technology of Yunnan Province(XDYC-KJLJ-2022-0004)。
文摘Flight feathers represent a hallmark innovation of avian evolution.Recent comparative genomic analyses identified a 284 bp avian-specific highly conserved element(ASHCE)located within the eighth intron of the SIM bHLH transcription factor 1(Sim1)gene,postulated to act as a cis-regulatory element governing flight feather morphogenesis.To investigate its functional significance,genome-edited(GE)primordial germ cell(PGC)lines carrying targeted ASHCE deletions were generated using CRISPR/Cas9-mediated editing,with germline chimeric males subsequently mated with wild-type(WT)hens to obtain GE progeny.The resulting GE chickens harbored 257-260 bp deletions,excising approximately half of the Sim1-ASHCE sequence.Reverse transcription-quantitative real-time polymerase chain reaction(RT-qPCR)analysis showed an average 0.32-fold reduction in Sim1 expression in the forelimbs of GE embryos at day 8(E8)compared to WT counterparts.Despite this,GE chickens developed structurally normal flight and tail feathers.In situ hybridization localized Sim1 expression to the posterior mesenchyme surrounding flight feather buds in E8 WT embryos,but not within the buds themselves.These results suggest that partial deletion of Sim1-ASHCE,despite diminishing Sim1 expression,does not disrupt flight feather formation.The excised region appears to possess enhancer activity toward Sim1 but is dispensable for flight feather development.Complete ablation of the ASHCE will be necessary to fully resolve the regulatory role of Sim1 in avian feather morphogenesis.
文摘The discontinuation of denosumab[antibody targeting receptor activator of nuclear factor kappa B ligand(RANKL)]therapy may increase the risk of multiple vertebral fractures;however,the underlying pathophysiology is largely unknown.In patients who underwent discontinuation after multiple injections of denosumab,the levels of tartrate-resistant acid phosphatase 5b increased compared to pretreatment levels,indicating a phenomenon known as“overshoot.”The rate of decrease in bone mineral density during the withdrawal period was higher than the rate of decrease associated with aging,suggesting that the physiological bone metabolism had broken down.Overshoot and significant bone loss were also observed in mice receiving continuous administration of anti-RANKL antibody after treatment was interrupted,resembling the original pathology.In mice long out of overshoot,bone resorption recovered,but osteoblast numbers and bone formation remained markedly reduced.The bone marrow exhibited a significant reduction in stem cell(SC)antigen 1-and platelet-derived growth factor receptor alpha-expressing osteoblast progenitors(PαS cells)and alkaline phosphatase-positive early osteoblasts.Just before the overshoot phase,the osteoclast precursor cell population expands and RANKL-bearing extracellular vesicles(EVs)became abundant in the serum,leading to robust osteoclastogenesis after cessation of anti-RANKL treatment.Thus,accelerated bone resorption due to the accumulation of RANKLbearing EVs and long-term suppression of bone formation uncoupled from bone resorption leads to the severe bone loss characteristic of denosumab discontinuation.
基金supported by the Special Edu-cational Research Budget(Research Promotion)[FY2009]the Special Budget(Project)[FY2010 and later years]from the Ministry of Education,Culture,Sports,Science and Technology(MEXT),Japansupported by the GRENE Arctic Climate Change Research Project,Japan
文摘To comprehensively understand the Arctic and Antarctic upper atmosphere, it is often crucial to analyze various data that are obtained from many regions. Infrastructure that promotes such interdisciplinary studies on the upper atmosphere has been developed by a Japanese inter-university project called the Inter-university Upper atmosphere Global Observation Network （1UGONET）. The objective of this paper is to describe the infrastructure and tools developed by IUGONET. We focus on the data analysis software. It is written in Interactive Data Language （IDL） and is a plug-in for the THEMIS Data Analysis Software suite （TDAS）, which is a set of IDL libraries used to visualize and analyze satellite- and ground-based data. We present plots of upper atmospheric data provided by IUGONET as examples of applications, and verify the usefulness of the software in the study of polar science. We discuss IUGONET＇s new and unique developments, i.e., an executable file of TDAS that can run on the IDL Virtual Machine, IDL routines to retrieve metadata from the IUGONET database, and an archive of 3-D simulation data that uses the Common Data Format so that it can easily be used with TDAS.
基金supported by the Natural Science Foundation of Henan Province(No.202300410433)the College Students’Innovative Entrepreneurial Training(No.2022cxcy029),ChinaHirosaki University,Japan,are appreciated.
文摘Amorphous high-entropy materials with abundant defects,coordinatively unsaturated sites,and loosely bonded atoms could exhibit excellent electrocatalytic performance.However,how to fabricate such ma-terials with nanostructure as well as amorphous structure is still full of challenges.In this work,high-entropy metal organic framework(HE-MOF)is employed as the self-sacrificial template to fabricate FeCoNiCuMnP x high-entropy phosphide/carbon(HEP/C)composites.The obtained composite shows a het-erostructured fusiform morphology,in which the HEP is encapsulated by a carbon layer,revealing high electron conductivity as well as rich catalytic active sites for oxygen evolution reaction(OER).Beside,it is found that there is a short-range ordered crystal structure in the amorphous phase,which is bene-ficial for revealing high OER catalytic activity as well as good stability.As a result,the optimum HEP/C composite shows an overpotential 239 mV@10 mA cm^(−2)with a small Tafel slope of 72.5 mV dec^(−1) for catalyzing OER in alkaline solution.
基金We acknowledge funding from NSFC Grant 62306283.
文摘Since the 1950s,when the Turing Test was introduced,there has been notable progress in machine language intelligence.Language modeling,crucial for AI development,has evolved from statistical to neural models over the last two decades.Recently,transformer-based Pre-trained Language Models(PLM)have excelled in Natural Language Processing(NLP)tasks by leveraging large-scale training corpora.Increasing the scale of these models enhances performance significantly,introducing abilities like context learning that smaller models lack.The advancement in Large Language Models,exemplified by the development of ChatGPT,has made significant impacts both academically and industrially,capturing widespread societal interest.This survey provides an overview of the development and prospects from Large Language Models(LLM)to Large Multimodal Models(LMM).It first discusses the contributions and technological advancements of LLMs in the field of natural language processing,especially in text generation and language understanding.Then,it turns to the discussion of LMMs,which integrates various data modalities such as text,images,and sound,demonstrating advanced capabilities in understanding and generating cross-modal content,paving new pathways for the adaptability and flexibility of AI systems.Finally,the survey highlights the prospects of LMMs in terms of technological development and application potential,while also pointing out challenges in data integration,cross-modal understanding accuracy,providing a comprehensive perspective on the latest developments in this field.
基金by JST FOREST Program(Grant No.JPMJFR203W,Japan)MEXT through Grant-in-Aid for Scientific Research(B)(No.19H02473,2019-2021)+2 种基金Grant-in-Aid for Scientific Research on Innovative Areas(Research in a proposed research area)(No.18H05456,2018-2022)the partial support through the research grant funded by the Amada Foundation(2022-2023)the financial support from the Amada Foundation(AF-2022017-B2).L.L.gratefully acknowledges the financial support provided by China Scholarship Council(No.201806295030)and thanks Dr.Elango Chandiran。
文摘Dynamic transformation(DT)of austenite(γ)to ferrite(α)in the hot deformation of various carbon steels was widely investigated.However,the nature of DT remains unclear due to the lack of quantitative analysis of stress partitioning between two phases and the uncertainty of local distribution of substitu-tional elements at the interface in multi-component carbon steels used in the previous studies.Therefore,in the present study,a binary Fe-Ni alloy withα+γduplex microstructure in equilibrium was prepared and isothermally compressed inα+γtwo-phase region to achieve a quantitative analysis of microstruc-ture evolution,stress partitioning,and thermodynamics during DT.γtoαDT during isothermal compres-sion andαtoγreverse transformation on isothermal annealing under unloaded condition after deforma-tion were accompanied by Ni partitioning.The lattice strains during thermomechanical processing were obtained via in-situ neutron diffraction measurement,based on which the stress partitioning behavior betweenγandαwas discussed by using the generalized Hooke’s law.A thermodynamic framework for the isothermal deformation in solids was established based on the basic laws of thermodynamics,and it was shown that the total Helmholtz free energy change in the deformable material during the isothermal process should be smaller than the work done to the deformable material.Under the present thermody-namic framework,the microstructure evolution in the isothermal compression of Fe-14Ni alloy was well explained by considering the changes in chemical free energy,plastic and elastic energies,and the work done to the material.In addition,the stabilization of the softαphase in Fe-14Ni alloy by deformation was rationalized since theγtoαtransformation decreased the total Helmholtz free energy by decreasing the elastic and dislocation energies.
基金supported by Grants-in-Aid for Scientific Research of the Japanese Society for the Promotion of Science(JSPS KAKENHI)Grant Number 18H00766(principal investigator:Takashi Nakata)Grant Number 18KK0027(principal investigator:Yasuhiro Kumahara).
文摘The Arun and Tista Rivers,which flow across the Himalayas,are commonly known as antecedent valleys that overcame the rapid uplift of the Higher Himalayan ranges.To clarify whether the idea of antecedent rivers is acceptable,we investigated the geomorphology of the Himalayas between eastern Nepal and Bhutan Himalayas.The southern part of Tibetan Plateau,extending across the Himalayas as tectonically un-deformed glaciated terrain named as'Tibetan Corridor,'does not suggest the regional uplift of the Higher Himalayas.The 8,000-m class mountains of Everest,Makalu,and Kanchenjunga are isolated residual peaks on the glaciated terrain composed of mountain peaks of 4,000–6,000 m high.The Tibetan glaciers commonly beheaded by Himalayan glaciers along the great watershed of the Himalayas suggest the expansion of Himalayan river drainage by glaciation.For the narrow upstream regions of the Arun and Tista Rivers with less precipitation behind the range,it is hard to collect enough water for the power of down-cutting their channels against the uplifting Himalayas.The fission track ages of the Higher Himalayan Crystalline Nappe suggest that the Himalayas attained their present altitude by 11–10 Ma,and the Arun and Tista Rivers formed deep gorges across the Himalayas by headward erosion.
基金supported by the JST CREST for Research Area“Nanomechanics”[JPMJCR2094]the JSPS KAKENHI for Scientific Research B[JP21H01673]the AMADA Foundation[AF-2023044-C2].
文摘The fracture toughness of extruded Mg-1Zn-2Y(at.%)alloys,featuring a multimodal microstructure containing fine dynamically recrystallized(DRXed)grains with random crystallographic orientation and coarse-worked grains with a strong fiber texture,was investigated.The DRXed grains comprised randomly oriented equiaxedα-Mg grains.In contrast,the worked grains includedα-Mg and long-period stacking ordered(LPSO)phases that extended in the extrusion direction(ED).Both types displayed a strong texture,aligning the(10.10)direction parallel to the ED.The volume fractions of the DRXed and worked grains were controlled by adjusting the extrusion temperature.In the longitudinal-transverse(L-T)orientation,where the loading direction was aligned parallel to the ED,there was a tendency for the conditional fracture toughness,KQ,tended to increase as the volume fraction of the worked grains increased.However,the KQ values in the T-L orientation,where the loading direction was perpendicular to the ED,decreased with an increase in the volume fraction of the worked grains.This suggests strong anisotropy in the fracture toughness of the specimen with a high volume fraction of the worked grains,relative to the test direction.The worked grains,which included the LPSO phase and were elongated perpendicular to the initial crack plane,suppressed the straight crack extension,causing crack deflection,and generating secondary cracks.Thus,these worked grains significantly contributed to the fracture toughness of the extruded Mg-1Zn-2Y alloys in the L-T orientation.
基金supported by JSPS KAKENHI Grant Number 22K03947.
文摘Visualization experiments were conducted to clarify the operational characteristics of a polymer pulsating heat pipe(PHP).Hydrofluoroether(HFE)-7100 was used as a working fluid,and its filling ratio was 50%of the entire PHP channel.A semi-transparent PHP was fabricated using a transparent polycarbonate sheet and a plastic 3D printer,and the movements of liquid slugs and vapor plugs of the working fluid were captured with a high-speed camera.The video images were then analyzed to obtain the flow patterns in the PHP.The heat transfer characteristics of the PHPwere discussed based on the flowpatterns and temperature distributions obtainedwith thermocouples.Before starting heating,because of high wettability,large liquid slugs positioned at the evaporator section of the PHP.After starting heating,since the occurrence of boiling divided the large liquid slugs,oscillatory flowof smaller liquid slugs and vapor plugs was found in the PHP.Clear circulation flow of liquid slugs and vapor plugs was observed when the power input to the PHP was larger than 12.0 W.The flow patterns and temperature distributions confirmed that the circulation flow enhanced the heat transfer from the evaporator section to the condenser section of the PHP.In the circulation flow mode,large growth and contraction of vapor plugs were found one after another in all even-numbered PHP channels.However,the analysis of flow patterns clarified that the phase-change heat transfer rate by large growth and contraction of vapor plugs was 19%of the total heat transfer rate of the PHP.Although the generation of large vapor plugs was found in the PHP,most of the heat was transferred by the sensible heat of the working fluid.
基金supported by MEXT Quantum Leap Flagship Program(MEXT Q-LEAP)Grant Number JPMXS0118067246.
文摘GHz burst-mode femtosecond(fs)laser,which emits a series of pulse trains with extremely short intervals of several hundred picoseconds,provides distinct characteristics in materials processing as compared with the conventional irradiation scheme of fs laser(single-pulse mode).In this paper,we take advantage of the moderate pulse interval of 205 ps(4.88 GHz)in the burst pulse for high-quality and high-efficiency micromachining of single crystalline sapphire by laser induced plasma assisted ablation(LIPAA).Specifically,the preceding pulses in the burst generate plasma by ablation of copper placed behind the sapphire substrate,which interacts with the subsequent pulses to induce ablation at the rear surface of sapphire substrates.As a result,not only the ablation quality but also the ablation efficiency and the fabrication resolution are greatly improved compared to the other schemes including single-pulse mode fs laser direct ablation,single-pulse mode fs-LIPAA,and nanosecond-LIPAA.
基金supported by the JST CREST for Research Area“Nanomechanics”[JPMJCR2094]the AMADA Foundation[AF-2023044-C2].
文摘This study aims to investigate the extrusion temperature effects on the development of heterogeneous microstructures and mechanical properties,focusing on their impact on the fracture toughness of AZ31B alloys.Magnesium AZ31B(Mg-3wt%Al-1wt%Zn)alloys with high strength and reasonable fracture toughness,featuring heterogeneous microstructures,were fabricated via warm/hot extrusion at temperatures ranging from 523 to 723 K.The AZ31B alloy extruded at 523 K was bimodally grained into coarse worked grains with high Kernel average misorientation(KAM)values and fine dynamically recrystallized(DRXed)grains(<10μm)with intermediate KAM values.The 523 K-extruded alloy exhibited a high tensile yield strength of∼280 MPa and fracture toughness KJIC of∼26 MPa·m^(1/2).Conversely,the 723 K-extruded AZ31B alloy was trimodally grained into a small amount of worked grains,fine DRXed grains,and coarse DRXed grains(>10μm)with low KAM values.The 723 K-extruded alloy exhibited low tensile yield strength but a high KJIC value of∼36 MPa·m^(1/2)owing to the high energy dissipation for crack extension in the coarse DRXed grains.
基金financially supported by JSPS KAKENHI Grant Number JP19K15083.
文摘A series of undrained triaxial tests was conducted to investigate the effect of crushed mudstone with the immersion-induced degradation on the liquefaction and post-liquefaction properties,and the undrained shearing behavior without precedent cyclic-loading histories of sands containing crushed mudstone.The tested materials with a main particle diameter of 2-0.85 mm were prepared by mixing sands and crushed mudstone to reach the prescribed mudstone content defined by dry mass ranging from 0% to 50%.The mixtures were subjected to immersion under a certain stress level and were subsequently tested.In addition,one-dimensional compression tests were also supplementally performed to visually observe the immersion-induced degradation of crushed mudstone.The test results mainly showed that: (1) the liquefaction resistance,the post-liquefaction undrained strength,and the undrained strength without a precedent cyclic-loading history decreased significantly with increasing mudstone content,M c ,up to 20%;(2) even a small amount of crushed mudstone affected these strengths;(3) the above-mentioned large reductions in the strengths were attributed to the immersion-induced degradation of crushed mudstone;(4) at M_(c) >20%,the liquefaction resistance increased while the significant increase in the undrained static strengths with and without precedent cyclic-loading histories was not observed;and (5) the increase in the liquefaction resistance at M_(c) >20% may have been attributed to both the gradual increase in the plasticity and the formation of the soil aggregates among deteriorated crushed mudstone,while the increase in the specimen density did not play an important role in such behavior.
基金supported by Grants-in-Aid for Scientific Research C(JP21K04693)from JSPS,Japan。
文摘Mg_(97)Zn_(1)Y_(2)alloys with high ignition temperatures were developed by adding Sr.The addition of Sr resulted in the formation of a uniform and thin Y_(2)O_(3)film.Mg–Zn–Y alloys containing at least 0.25 at.%Sr exhibited ignition temperatures of 1270–1320 K.As a result of EDS measurement,Sr was found to be concentrated in the Y_(2)O_(3)film.In addition,a mixed film of MgO and Sr O formed on the outer layer in the 1.5 at.%Sr-containing Mg_(97)Zn_(1)Y_(2)alloy.These findings suggest that the uniform and thin Y_(2)O_(3)film that maintains high soundness at high temperatures was formed owing to valence control and the formation of a protective outer oxide film.
基金supported and funded by the Deanship of Scientific Research at Imam Mohammad Ibn Saud Islamic University(IMSIU),Grant Number IMSIU-RG23151.
文摘This study explores the impact of hyperparameter optimization on machine learning models for predicting cardiovascular disease using data from an IoST(Internet of Sensing Things)device.Ten distinct machine learning approaches were implemented and systematically evaluated before and after hyperparameter tuning.Significant improvements were observed across various models,with SVM and Neural Networks consistently showing enhanced performance metrics such as F1-Score,recall,and precision.The study underscores the critical role of tailored hyperparameter tuning in optimizing these models,revealing diverse outcomes among algorithms.Decision Trees and Random Forests exhibited stable performance throughout the evaluation.While enhancing accuracy,hyperparameter optimization also led to increased execution time.Visual representations and comprehensive results support the findings,confirming the hypothesis that optimizing parameters can effectively enhance predictive capabilities in cardiovascular disease.This research contributes to advancing the understanding and application of machine learning in healthcare,particularly in improving predictive accuracy for cardiovascular disease management and intervention strategies.
