BACKGROUND While studies have suggested the association between triglyceride-glucose(TyG)index,a reliable surrogate for insulin resistance and hypertension data are limited to the correlation of TyG and central blood ...BACKGROUND While studies have suggested the association between triglyceride-glucose(TyG)index,a reliable surrogate for insulin resistance and hypertension data are limited to the correlation of TyG and central blood pressure.This study aims to test the hypothesis that a higher TyG index is associated with elevated central systolic blood pressure(cSBP).METHODS A total of 9249 Chinese hypertensive adults from the H-type Hypertension and Stroke Prevention and Control Project were analyzed in this study.cSBP was measured noninvasively using an A-Pulse CASPro device.TyG index was calculated as ln[fasting triglycerides(mg/dL)×fasting glucose(mg/dL)/2].Smoothing curve and multivariate linear regression models[beta coefficient(β)with 95%CI]were applied to analyze the association between TyG index and cSBP.Subgroup analyses were conducted to explore potential modifications to such a correlation.RESULTS The overall mean TyG index is 8.8±0.7,and the total mean cSBP is 131.3±12.8 mmHg.TyG index was observed to be independently and positively associated with cSBP among the total population(β=0.92,95%CI:0.53–1.31,P<0.001),and participants who do not use antihypertensive drugs(β=1.03,95%CI:0.46–1.60,P<0.001),which is in accordance with the result of the smoothing curve.The association between TyG index and cSBP appears robust in all tested subgroups.CONCLUSIONS TyG index is positively and independently associated with cSBP among hypertensive adults.Our study result suggests that TyG index might serve as an effective marker for vascular function.展开更多
This article focuses on a technique for shallow mechanical improvement of soil which deals with the utilization of crushed granite mixed in a certain percentage with lateritic soils during road construction in Burkina...This article focuses on a technique for shallow mechanical improvement of soil which deals with the utilization of crushed granite mixed in a certain percentage with lateritic soils during road construction in Burkina Faso.Lithostab is the simplified name for litho-stabilization,a technique for improving laterite by adding crushed granite that increases the CBR(California bearing ratio)of that material for being used in road construction.Class 0/25 of crushed granite added to a laterite in our case gives good performance in terms of CBR.Indeed,the CBR index which was initially 48 at 98%of the OMP(optimum modified Proctor)goes to 88.And from 84 at 98%of the OMP,it goes to 128 for 30%of class 0/25 of crushed granite added.This means that class 0/25 of crushed granite provides better CBR index to that material when it is incorporated at 30%.So,lithostab is an easy to implement eco-friendly material for road construction because of the utilization of local materials.Then,it contributes to the protection of the environment in the sense that its production does not require a lot of energy and does not release large quantities of carbon dioxide into the atmosphere.展开更多
Objective To observe the effects of Huashi Tongbi Formula(HTF)on blood lipid levels,endothelial cell function,and gut microbiota in rats with erectile dysfunction(ED).Methods SD rats were randomly divided into blank g...Objective To observe the effects of Huashi Tongbi Formula(HTF)on blood lipid levels,endothelial cell function,and gut microbiota in rats with erectile dysfunction(ED).Methods SD rats were randomly divided into blank group,sham operation group,model group,sildenafil group,and HTF low,medium,and high dose groups,with 7 rats in each group.Hyperlipidemia combined with bilateral internal iliac artery ligation were used to establish ED model.After modeling,the sildenafil group received sildenafil(4.5 mg/kg)by gavage,while the HTF group received low,medium,and high doses(3.24,6.48,12.96 g/kg)of HTF by gavage.The other three groups received an equal volume of physiological saline by gavage.After 6weeks of intervention,the intracavernous pressure(ICP)of the penis and mean carotid artery pressure(MAP)were measured using a multi-channel physiological signal recorder,and the ICP/MAP were calculated,the number of erections in rats was recorded.Serum total cholesterol(TC),high-density lipoprotein cholesterol(HDL-C),and low-density lipoprotein cholesterol(LDLC)were measured using a fully automated biochemical analyzer.ELISA was used to detect the levels of vascular endothelial growth factor(VEGF),endothelin-1(ET-1)in serum,and microplate method was used to detect the level of nitric oxide(NO)in the corpus cavernosum tissue of rats.16 S rDNA sequencing was used to detect the gut microbiota of rats.Results Compared with baseline,the serum LDL-C levels of rats in each dose group of HTF decreased,HDL-C levels increased(P<0.05),the TC levels of rats in the medium dose group of HTF decreased(P<0.05).Compared with the blank group,the model group showed a decrease in number of erections,ICP/MAP,serum HDL-C,and NO levels in the corpus cavernosum tissue of the penis,while serum TC,LDL-C,VEGF,and ET-1 levels increased(P<0.05).Compared with the sham operation group,the model group showed a decrease in number of erections and an increase in serum VEGF and ET-1 levels(P<0.05).Compared with the model group,the sildenafil group showed a decrease in serum ET-1 levels and an increase in NO levels in the corpus cavernosum tissue of the penis(P<0.05).The levels of serum LDL-C,VEGF,and ET-1 in rats of various doses of HTF decreased,while the level of HDL-C increased(P<0.05).The low dose group of HTF had an increase in the level of NO in the corpus cavernosum tissue of the penis,while the medium dose group of HTF had an increase in the number of erections and a decrease in serum TC levels(P<0.05).Compared with the sildenafil group,the serum LDL-C and VEGF levels of rats in each dose group of HTF decreased,the HDL-C levels of rats in the low and high dose groups of HTF increased,and the ET-1 levels of rats in the low dose group of HTF decreased(P<0.05).Analysis of gut microbiota showed that HTF could affect the structure of gut microbiota.Compared with the blank group,the abundance of Butyricicoccus,Ruminococcus,Prevotellaceae_UCG-OOl,and Anaerotruncus increased in the model group,while the abundance of Candidatus_Stoquefichus,Facklamia,Jeotgalicoccus,and Enterococcus decreased(P<0.05).Compared with the model group,the HTF mediumdose groupSshowedan increase inthe abundance of Staphylococcus,Faecalibacterium,Jeotgalicoccus,Halomonas,Negativibacillus,Achromobacter,Subdoliguranulus,Lachnospiraceae UCG-010,Bilophila,and Nosocomicoccus(P<0.05),while Faecalibacterium,Family_XIll_UCG-001,and Lachnospiraceae_UCG-006,Butyricicoccus,unidentified_Ruminococcaceae,Lachnospiraceae_ND3007_group,and Lactococcus decreased(P<0.05).Conclusion The HTF may improve lipid disorders and vascular endothelial cell function in rats via affecting the abundance and diversity of gut microbiota,thereby to enhance erectile function.展开更多
Objective To observe the effects of antagonistic needling therapy on lower limb spasticity and the muscle morphology of the tibialis anterior and gastrocnemius in patients with stroke.Methods A total of 100 patients w...Objective To observe the effects of antagonistic needling therapy on lower limb spasticity and the muscle morphology of the tibialis anterior and gastrocnemius in patients with stroke.Methods A total of 100 patients with post-stroke lower limb spasticity were randomly divided into an antagonistic needling group(50 cases,1 case dropped out)and a routine acupuncture group(50 cases,1 case dropped out).Both groups received basic treatment and rehabilitation training.Theroutine acupuncture group was treated with scalp acupuncture at anterior oblique line of vertex-temporal and vertex lateral line 1,combined with body acupuncture at Jianyu(LI15),Hegu(LI4),Zusanli(ST36),Taichong(LR3),etc.on the affected side,with Quchi(LIl1)and Hegu(LI4),Zusanli(ST36)and Fenglong(ST40),Yanglingquan(GB34)and Taichong(LR3)connected to an electroacupuncture device,using disperse wave at 2 Hz of frequency.The antagonistic needling group used the same scalp and upper limb acupoints as the routine acupuncture group,with additional antagonistic needling on the lower limb at Yanglingquan(GB34),Qiuxu(GB40),Jiexi(ST41),and Xuanzhong(GB39)on the affected side,with Quchi(LIl1)and Hegu(LI4),Yanglingquan(GB34)and Qiuxu(GB40),Jiexi(ST41),and Xuanzhong(GB39)connected to an electroacupuncture device,using disperse wave at 2 Hz of frequency.Both groups received treatment once daily for 6 consecutive days per course,with a total of 4 courses.The modified Ashworth scale(MAS),Holden functional ambulation classification(FAC),lower limb Fugl-Meyer assessment(FMA),composite spasticity scale(CSS),and musculoskeletal ultrasound parameters(thickness and fiber length of the tibialis anterior and gastrocnemius,and pennation angle of the gastrocnemius on both sides) were evaluated before and after treatment.Clinical efficacy was compared between the two groups.Results Compared before treatment,the MAS grades and CSS scores were decreased in both groups after treatment(P<0.01),with greater reductions in the antagonistic needling group(P<0.05,P<0.01).FAC grades and FMA scores were increased in both groups after treatment(P<0.01,P<0.05),with greater improvements in the antagonistic needling group(P<0.05).The muscle thickness,fiber length of the tibialis anterior,the muscle thickness,fiber length and pennation angle of the gastrocnemius on the affected side were improved in both groups after treatment(P<0.01),with greater improvements in the antagonistic needling group(P<0.01,P<0.05).On the unaffected side,these parameters were also increased after treatment in both groups(P<0.01,P<0.05),but the antagonistic needling group showed smaller increases than the routine acupuncture group(P<0.01,P<0.05).The total effective rate in the antagonistic needling group was 91.8%(45/49),higher than 81.6%(40/49)in the routine acupuncture group(P<0.05).Conclusion Antagonistic needling could effectively reduce spasticity,improve motor function,and enhance muscle structure in patients with post-stroke lower limb spasticity.展开更多
Objective To investigate the correlation of Clq/tumor necrosis factor-related protein-6(CTRP6),Irisin and type 2 diabetes mellitus(T2DM).Methods A total of 80 T2DM patients who visited the Endocrinology Department of ...Objective To investigate the correlation of Clq/tumor necrosis factor-related protein-6(CTRP6),Irisin and type 2 diabetes mellitus(T2DM).Methods A total of 80 T2DM patients who visited the Endocrinology Department of Bayannur City Hospital from March 2022 to October 2022 were selected as the T2DM group,and 80 healthy subjects were selected as the normal control(NC)group.Serum CTRP6,Irisin,adiponectin(APN),tumor necrosis factor alpha(TNF-α),interleukin 6(IL-6),fasting plasma glucose(FPG),Blood glucose 2 h after 25 g glucose load(2 hPG),fasting insulin(FIns),insulin resistance index(HOMAIR),glycated hemoglobin(HbA,c),body mass index(BMI)and visceral fat area(VFA)were measured and compared between the two group.Results Compared with the NC group,the serum CTRP6 level in the study group was significantly increased[(150.69±29.57)us(116.05±29.06)pg/ml,P<0.05],and the Irisin level was significantly decreased[145.56(117.50,191.75)vs 205.19(142.15,334.69)pg/ml,P<0.05]in T2DM group.Spearman correlation analysis showed that serum CTRP6 was positively correlated with BMI,VFA,FPG,2 hPG,FIns,HOMA-IR,HbA_(1)c,IL-6,and TNF-α(r=0.255,0.243,0.500,0.434,0.237,0.456,0.470,0.284and0.222,P<0.05)and negatively correlated with age(r=-0.113,P<0.05).Serum Irisin was negatively correlated with BMI,FPG,2 hPG,HOMA-IR and HbA,c(r=-0.201,-0.295,-0.278,-0.234 and-0.352,P<0.05),and positively correlated with APN and IL-6(r=0.248,0.248,P<0.05).Multiple linear regression analysis showed that VFA,FIns,HOMA-IR,APN and IL-6 were independent influencing factors of CTRP6,and IL-6 was an independent influencing factor of Irisin.Logistic regression analysis showed that HOMA-IR,CTRP6 and Irisin were independent predictors of T2DM.Receiver operating characteristic curve analysis showed that the area under the curve(AUC)of serum CTRP6 for predicting T2DM was 0.795,the AUC of serum Irisin for predicting T2DM was 0.669,and the AUC of the combination predicting T2DM was 0.832.Conclusion Serum CTRP6 and Irisin are closely related to T2DM and have high predictive value for T2DM.展开更多
Halorhodospira(Hlr.)halochloris is a triply extremophilic phototrophic purple sulfur bacterium,as it is thermophilic,alkaliphilic,and extremely halophilic.The light-harvesting-reaction center(LH1–RC)core complex of t...Halorhodospira(Hlr.)halochloris is a triply extremophilic phototrophic purple sulfur bacterium,as it is thermophilic,alkaliphilic,and extremely halophilic.The light-harvesting-reaction center(LH1–RC)core complex of this bacterium displays an LH1-Q_(y)transition at 1,016 nm,which is the lowest-energy wavelength absorption among all known phototrophs.Here we report the cryo-EM structure of the LH1–RC at 2.42?resolution.The LH1 complex forms a tricyclic ring structure composed of 16αβγ-polypeptides and oneαβ-heterodimer around the RC.From the cryo-EM density map,two previously unrecognized integral membrane proteins,referred to as protein G and protein Q,were identified.Both of these proteins are single transmembrane-spanning helices located between the LH1 ring and the RC Lsubunit and are absent from the LH1–RC complexes of all other purple bacteria of which the structures have been determined so far.Besides bacteriochlorophyll b molecules(B1020)located on the periplasmic side of the Hlr.halochloris membrane,there are also two arrays of bacteriochlorophyll b molecules(B800 and B820)located on the cytoplasmic side.Only a single copy of a carotenoid(lycopene)was resolved in the Hlr.halochloris LH1–α3β3 and this was positioned within the complex.The potential quinone channel should be the space between the LH1–α3β3 that accommodates the single lycopene but does not contain aγ-polypeptide,B800 and B820.Our results provide a structural explanation for the unusual Q_(y)red shift and carotenoid absorption in the Hlr.halochloris spectrum and reveal new insights into photosynthetic mechanisms employed by a species that thrives under the harshest conditions of any phototrophic microorganism known.展开更多
Objective To explore the mechanism of gypenosides(GPs) preventing and treating atherosclerosis (AS)through Bcl2L12-mediated apoptosis pathway.Methods ApoE^(-/-) mice were selected and randomly divided into model group...Objective To explore the mechanism of gypenosides(GPs) preventing and treating atherosclerosis (AS)through Bcl2L12-mediated apoptosis pathway.Methods ApoE^(-/-) mice were selected and randomly divided into model group and GPs group (high-fat feeding for 12weeks),and C57BL/6J mice were used as normal group,with 8 mice in each group.展开更多
Objective Based on the Forkhead Box P3(Foxp3)/Retinoic acid-related orphan receptorγt (RORγt)immune imbalance mechanism,to analyze the changes of related cytokines and intestinal flora,and to explore the mechanism o...Objective Based on the Forkhead Box P3(Foxp3)/Retinoic acid-related orphan receptorγt (RORγt)immune imbalance mechanism,to analyze the changes of related cytokines and intestinal flora,and to explore the mechanism of Xuanbai Chengqi Decoction (XBCQD) on lung and intestinal injury caused by influenza virus (Ⅳ)and Streptococcus pneumoniae (SPN) co-infection.展开更多
Objective To observe the effects of electroacupuncture(EA) at"Jiaji"(EX-B 2) combined with neurodynamic mobilization (NM) on the cross-sectional area of the gastrocnemius muscle fibers after sciatic nerve in...Objective To observe the effects of electroacupuncture(EA) at"Jiaji"(EX-B 2) combined with neurodynamic mobilization (NM) on the cross-sectional area of the gastrocnemius muscle fibers after sciatic nerve injury in rabbits,and the expression of nuclear factor-κB (NF-κB) and muscle-specific ring-finger protein 1 (MuRF1).展开更多
Objective To explore the clinical differences among patients with chronic heart failure(CHF)with different Chinese medicine(CM)syndromes,and to identify the influencing factors of yang qi depletion and blood stasis sy...Objective To explore the clinical differences among patients with chronic heart failure(CHF)with different Chinese medicine(CM)syndromes,and to identify the influencing factors of yang qi depletion and blood stasis syndrome.Methods Totally 179 patients with CHF was conducted in the Department of Integrative Cardiology,China-Japan Friendship Hospital,including 58 cases of qi deficiency and blood stasis syndrome(QBS),31 cases of qi and,yin deficiency and blood stasis syndrome(QYBS),and 90 cases of yang qi depletion and blood stasis syndrome(YBS).展开更多
Objective To evaluate the efficacy,anticoagulant role,and effect on aspirin resistance(AR)of Longchai Jiangxue Formula(LCJX)intreating essential thrombocythemia(ET).Methods Seventy-two patients with ET met the inclusi...Objective To evaluate the efficacy,anticoagulant role,and effect on aspirin resistance(AR)of Longchai Jiangxue Formula(LCJX)intreating essential thrombocythemia(ET).Methods Seventy-two patients with ET met the inclusion criteria at the Department of Hematology,Xiyuan Hospital,China Academy of Chinese Medical Sciences,from October 2021 to December 2022,and were assigned to the control group and the observation group,with 36 cases in each group by using the method of randomized numerical table.展开更多
Objective To explore the influence of family history of diabetes and central obesity on prediabetes (Pre-DM)and their interaction.Methods Based on the REACTION study during August December 2011 in Dalian,2 587 individ...Objective To explore the influence of family history of diabetes and central obesity on prediabetes (Pre-DM)and their interaction.Methods Based on the REACTION study during August December 2011 in Dalian,2 587 individuals aged≥40 with normal blood glucose (BG)were divided into newly diagnosed Pre-DM (n=522) and BG normal group(NC,n=2 065) during follow-up.展开更多
Objective To evaluate the effects of Qingda Granules (QDG) on office blood pressure (OBP) and the anxiety score in patients with grade 1 hypertension with different levels of anxiety.Methods A randomized,multicenter,d...Objective To evaluate the effects of Qingda Granules (QDG) on office blood pressure (OBP) and the anxiety score in patients with grade 1 hypertension with different levels of anxiety.Methods A randomized,multicenter,double-blinded,non-inferiority clinical trial design was adopted.A total of 552 patients with grade 1hypertension were randomly assigned to the treatment group(276 cases) and the control group (276 cases).展开更多
Objective To observe the effects of Modified Chaihu Shugan Formula (MCSF) on the behavior of epileptic mice and their regulatory effects on long noncoding RNAUCA1(lncRNA-UCA1),microRNA-187(miR-187) and recombinant mit...Objective To observe the effects of Modified Chaihu Shugan Formula (MCSF) on the behavior of epileptic mice and their regulatory effects on long noncoding RNAUCA1(lncRNA-UCA1),microRNA-187(miR-187) and recombinant mitogen activated protein kinase 8(MAPK8).Methods Totally 80 mice were randomly divided into normal group,model group (pilocarpine hydrochloride 180 mg/kg).展开更多
Objective To investigate the inhibitory effect of Gandou Decoction combined with penicillamine on cuproptosis in the liver of toxic milk (TX) mice,which serve as a model for Wilson's disease (WD).Methods Using dil...Objective To investigate the inhibitory effect of Gandou Decoction combined with penicillamine on cuproptosis in the liver of toxic milk (TX) mice,which serve as a model for Wilson's disease (WD).Methods Using dilute lethal (DL) mice as the normal control group,and TX mice were randomly divided into model group,Gandou Decoction group,penicillamine group,and Gandou Decoction combined with penicillamine group,with 8 mice in each group.展开更多
Objective To evaluate proximal gastric function in patients with functional dyspepsia(FD)met RomeⅢcriteria and its subtypes.Methods Thirty FD patients were enrolled,including 15 patients with postprandial distress sy...Objective To evaluate proximal gastric function in patients with functional dyspepsia(FD)met RomeⅢcriteria and its subtypes.Methods Thirty FD patients were enrolled,including 15 patients with postprandial distress syndrome(PDS)and 15 patients with epigastric pain syndrome(EPS).A total of 30 healthy volunteers were recruited as control.All the subjects received barostat examination.Minimal distending pressure(MDP),展开更多
Objective To observe the the therapeutic efficacy of Dahuang Fuzi Decoction in patients with acute respiratory distress syndrome(ARDS)and severe acute pancreatitis(SAP).Methods A prospective,multi-center。
Objective The pathogenesis of irritable bowel syndrome (IBS) ,a functional gastrointestinal disorder,is poorly understood.Treatment with Chinese medicine and pharmacy (CMP) is superior to treatment with Western medici...Objective The pathogenesis of irritable bowel syndrome (IBS) ,a functional gastrointestinal disorder,is poorly understood.Treatment with Chinese medicine and pharmacy (CMP) is superior to treatment with Western medicine (WM) .Therefore,we aimed to展开更多
Objective To investigate the morphological changes of the brainstem in patients with Alzheimer's disease(AD)and their relationship with hippocampal morphological changes.Methods Sixty AD patients(AD group)and sixt...Objective To investigate the morphological changes of the brainstem in patients with Alzheimer's disease(AD)and their relationship with hippocampal morphological changes.Methods Sixty AD patients(AD group)and sixty age-and gender-matched normal elderly(normal control group)were selected from the Alzheimer's Disease Neuroimaging Initiative(ADNI)database.The hippocampus and the brainstem of each subject were segmented and their normalized volumes were calculated.According to the hippocampal volume standard value(Z-score),AD patients were divided into two subgroups(hippocampal atrophy group(n=51)and hippocampal spared group(n=9)).A voxel-based morphology(VBM)study was also performed to investigate the morphological differences of the brainstem between the normal control group and the AD group,as well as between the AD subgroups.Results Compared with the normal control group,the brainstem volume in the AD group decreased significantly(16741.31±1739.11 vs 15609.67±1451.60,t=3.870,P=0.001).In the AD subgroups,the volume of the brainstem in the hippocampal atrophy group was significantly smaller than that in the hippocampal spared group(16556.30±1514.86 vs 15442.62±1389.05,t=2.189,P=0.033).Pearson correlation analysis showed that Mini-Mental State Examination scores were positively correlated with the hippocampal and the brainstem volumes(r=0.590,P<0.01;r=0.234,P<0.05),and there was a positive correlation between the hippocampal and the brainstem volume changes in patients with AD(r=0.315,P=0.014).VBM results showed that both the bilateral midbrain and the bilateral pons in the AD group had significant atrophy compared with the normal control group(P<0.05).In the AD subgroups,the bilateral midbrain and the left pons in the hippocampal atrophy group were significantly atrophied compared with the hippocampal spared group(P<0.05).Conclusion The brainstem shows morphological changes in patients with AD,and the morphological changes of the brainstem in AD patients with different degrees of hippocampal atrophy are different,indicating the morphological changes of the hippocampus and the brainstem may have an interrelated relationship.展开更多
Objective To study the changes of serum levels of Irisin and Galanin in patients with type 2 diabetes mellitus and obesity. Methods A total of 182 patients with type 2 diabetes (T2DM) hospitalized in Endocrinology and...Objective To study the changes of serum levels of Irisin and Galanin in patients with type 2 diabetes mellitus and obesity. Methods A total of 182 patients with type 2 diabetes (T2DM) hospitalized in Endocrinology and Metabolism Department in Baoding First Center Hospital were enrolled in this study. All the patients were divided into three groups according to their BMI: normal weight group (NW), diabetic overweight group (OW) and diabetes and obesity group (OB).展开更多
基金supported by the National Natural Science Foundation of China(No.81960074)the Key R&D Projects,Jiangxi(20203BBGL73173)the Pro-ject of Jiangxi Provincial Health Commission(No.202130440).
文摘BACKGROUND While studies have suggested the association between triglyceride-glucose(TyG)index,a reliable surrogate for insulin resistance and hypertension data are limited to the correlation of TyG and central blood pressure.This study aims to test the hypothesis that a higher TyG index is associated with elevated central systolic blood pressure(cSBP).METHODS A total of 9249 Chinese hypertensive adults from the H-type Hypertension and Stroke Prevention and Control Project were analyzed in this study.cSBP was measured noninvasively using an A-Pulse CASPro device.TyG index was calculated as ln[fasting triglycerides(mg/dL)×fasting glucose(mg/dL)/2].Smoothing curve and multivariate linear regression models[beta coefficient(β)with 95%CI]were applied to analyze the association between TyG index and cSBP.Subgroup analyses were conducted to explore potential modifications to such a correlation.RESULTS The overall mean TyG index is 8.8±0.7,and the total mean cSBP is 131.3±12.8 mmHg.TyG index was observed to be independently and positively associated with cSBP among the total population(β=0.92,95%CI:0.53–1.31,P<0.001),and participants who do not use antihypertensive drugs(β=1.03,95%CI:0.46–1.60,P<0.001),which is in accordance with the result of the smoothing curve.The association between TyG index and cSBP appears robust in all tested subgroups.CONCLUSIONS TyG index is positively and independently associated with cSBP among hypertensive adults.Our study result suggests that TyG index might serve as an effective marker for vascular function.
文摘This article focuses on a technique for shallow mechanical improvement of soil which deals with the utilization of crushed granite mixed in a certain percentage with lateritic soils during road construction in Burkina Faso.Lithostab is the simplified name for litho-stabilization,a technique for improving laterite by adding crushed granite that increases the CBR(California bearing ratio)of that material for being used in road construction.Class 0/25 of crushed granite added to a laterite in our case gives good performance in terms of CBR.Indeed,the CBR index which was initially 48 at 98%of the OMP(optimum modified Proctor)goes to 88.And from 84 at 98%of the OMP,it goes to 128 for 30%of class 0/25 of crushed granite added.This means that class 0/25 of crushed granite provides better CBR index to that material when it is incorporated at 30%.So,lithostab is an easy to implement eco-friendly material for road construction because of the utilization of local materials.Then,it contributes to the protection of the environment in the sense that its production does not require a lot of energy and does not release large quantities of carbon dioxide into the atmosphere.
文摘Objective To observe the effects of Huashi Tongbi Formula(HTF)on blood lipid levels,endothelial cell function,and gut microbiota in rats with erectile dysfunction(ED).Methods SD rats were randomly divided into blank group,sham operation group,model group,sildenafil group,and HTF low,medium,and high dose groups,with 7 rats in each group.Hyperlipidemia combined with bilateral internal iliac artery ligation were used to establish ED model.After modeling,the sildenafil group received sildenafil(4.5 mg/kg)by gavage,while the HTF group received low,medium,and high doses(3.24,6.48,12.96 g/kg)of HTF by gavage.The other three groups received an equal volume of physiological saline by gavage.After 6weeks of intervention,the intracavernous pressure(ICP)of the penis and mean carotid artery pressure(MAP)were measured using a multi-channel physiological signal recorder,and the ICP/MAP were calculated,the number of erections in rats was recorded.Serum total cholesterol(TC),high-density lipoprotein cholesterol(HDL-C),and low-density lipoprotein cholesterol(LDLC)were measured using a fully automated biochemical analyzer.ELISA was used to detect the levels of vascular endothelial growth factor(VEGF),endothelin-1(ET-1)in serum,and microplate method was used to detect the level of nitric oxide(NO)in the corpus cavernosum tissue of rats.16 S rDNA sequencing was used to detect the gut microbiota of rats.Results Compared with baseline,the serum LDL-C levels of rats in each dose group of HTF decreased,HDL-C levels increased(P<0.05),the TC levels of rats in the medium dose group of HTF decreased(P<0.05).Compared with the blank group,the model group showed a decrease in number of erections,ICP/MAP,serum HDL-C,and NO levels in the corpus cavernosum tissue of the penis,while serum TC,LDL-C,VEGF,and ET-1 levels increased(P<0.05).Compared with the sham operation group,the model group showed a decrease in number of erections and an increase in serum VEGF and ET-1 levels(P<0.05).Compared with the model group,the sildenafil group showed a decrease in serum ET-1 levels and an increase in NO levels in the corpus cavernosum tissue of the penis(P<0.05).The levels of serum LDL-C,VEGF,and ET-1 in rats of various doses of HTF decreased,while the level of HDL-C increased(P<0.05).The low dose group of HTF had an increase in the level of NO in the corpus cavernosum tissue of the penis,while the medium dose group of HTF had an increase in the number of erections and a decrease in serum TC levels(P<0.05).Compared with the sildenafil group,the serum LDL-C and VEGF levels of rats in each dose group of HTF decreased,the HDL-C levels of rats in the low and high dose groups of HTF increased,and the ET-1 levels of rats in the low dose group of HTF decreased(P<0.05).Analysis of gut microbiota showed that HTF could affect the structure of gut microbiota.Compared with the blank group,the abundance of Butyricicoccus,Ruminococcus,Prevotellaceae_UCG-OOl,and Anaerotruncus increased in the model group,while the abundance of Candidatus_Stoquefichus,Facklamia,Jeotgalicoccus,and Enterococcus decreased(P<0.05).Compared with the model group,the HTF mediumdose groupSshowedan increase inthe abundance of Staphylococcus,Faecalibacterium,Jeotgalicoccus,Halomonas,Negativibacillus,Achromobacter,Subdoliguranulus,Lachnospiraceae UCG-010,Bilophila,and Nosocomicoccus(P<0.05),while Faecalibacterium,Family_XIll_UCG-001,and Lachnospiraceae_UCG-006,Butyricicoccus,unidentified_Ruminococcaceae,Lachnospiraceae_ND3007_group,and Lactococcus decreased(P<0.05).Conclusion The HTF may improve lipid disorders and vascular endothelial cell function in rats via affecting the abundance and diversity of gut microbiota,thereby to enhance erectile function.
文摘Objective To observe the effects of antagonistic needling therapy on lower limb spasticity and the muscle morphology of the tibialis anterior and gastrocnemius in patients with stroke.Methods A total of 100 patients with post-stroke lower limb spasticity were randomly divided into an antagonistic needling group(50 cases,1 case dropped out)and a routine acupuncture group(50 cases,1 case dropped out).Both groups received basic treatment and rehabilitation training.Theroutine acupuncture group was treated with scalp acupuncture at anterior oblique line of vertex-temporal and vertex lateral line 1,combined with body acupuncture at Jianyu(LI15),Hegu(LI4),Zusanli(ST36),Taichong(LR3),etc.on the affected side,with Quchi(LIl1)and Hegu(LI4),Zusanli(ST36)and Fenglong(ST40),Yanglingquan(GB34)and Taichong(LR3)connected to an electroacupuncture device,using disperse wave at 2 Hz of frequency.The antagonistic needling group used the same scalp and upper limb acupoints as the routine acupuncture group,with additional antagonistic needling on the lower limb at Yanglingquan(GB34),Qiuxu(GB40),Jiexi(ST41),and Xuanzhong(GB39)on the affected side,with Quchi(LIl1)and Hegu(LI4),Yanglingquan(GB34)and Qiuxu(GB40),Jiexi(ST41),and Xuanzhong(GB39)connected to an electroacupuncture device,using disperse wave at 2 Hz of frequency.Both groups received treatment once daily for 6 consecutive days per course,with a total of 4 courses.The modified Ashworth scale(MAS),Holden functional ambulation classification(FAC),lower limb Fugl-Meyer assessment(FMA),composite spasticity scale(CSS),and musculoskeletal ultrasound parameters(thickness and fiber length of the tibialis anterior and gastrocnemius,and pennation angle of the gastrocnemius on both sides) were evaluated before and after treatment.Clinical efficacy was compared between the two groups.Results Compared before treatment,the MAS grades and CSS scores were decreased in both groups after treatment(P<0.01),with greater reductions in the antagonistic needling group(P<0.05,P<0.01).FAC grades and FMA scores were increased in both groups after treatment(P<0.01,P<0.05),with greater improvements in the antagonistic needling group(P<0.05).The muscle thickness,fiber length of the tibialis anterior,the muscle thickness,fiber length and pennation angle of the gastrocnemius on the affected side were improved in both groups after treatment(P<0.01),with greater improvements in the antagonistic needling group(P<0.01,P<0.05).On the unaffected side,these parameters were also increased after treatment in both groups(P<0.01,P<0.05),but the antagonistic needling group showed smaller increases than the routine acupuncture group(P<0.01,P<0.05).The total effective rate in the antagonistic needling group was 91.8%(45/49),higher than 81.6%(40/49)in the routine acupuncture group(P<0.05).Conclusion Antagonistic needling could effectively reduce spasticity,improve motor function,and enhance muscle structure in patients with post-stroke lower limb spasticity.
文摘Objective To investigate the correlation of Clq/tumor necrosis factor-related protein-6(CTRP6),Irisin and type 2 diabetes mellitus(T2DM).Methods A total of 80 T2DM patients who visited the Endocrinology Department of Bayannur City Hospital from March 2022 to October 2022 were selected as the T2DM group,and 80 healthy subjects were selected as the normal control(NC)group.Serum CTRP6,Irisin,adiponectin(APN),tumor necrosis factor alpha(TNF-α),interleukin 6(IL-6),fasting plasma glucose(FPG),Blood glucose 2 h after 25 g glucose load(2 hPG),fasting insulin(FIns),insulin resistance index(HOMAIR),glycated hemoglobin(HbA,c),body mass index(BMI)and visceral fat area(VFA)were measured and compared between the two group.Results Compared with the NC group,the serum CTRP6 level in the study group was significantly increased[(150.69±29.57)us(116.05±29.06)pg/ml,P<0.05],and the Irisin level was significantly decreased[145.56(117.50,191.75)vs 205.19(142.15,334.69)pg/ml,P<0.05]in T2DM group.Spearman correlation analysis showed that serum CTRP6 was positively correlated with BMI,VFA,FPG,2 hPG,FIns,HOMA-IR,HbA_(1)c,IL-6,and TNF-α(r=0.255,0.243,0.500,0.434,0.237,0.456,0.470,0.284and0.222,P<0.05)and negatively correlated with age(r=-0.113,P<0.05).Serum Irisin was negatively correlated with BMI,FPG,2 hPG,HOMA-IR and HbA,c(r=-0.201,-0.295,-0.278,-0.234 and-0.352,P<0.05),and positively correlated with APN and IL-6(r=0.248,0.248,P<0.05).Multiple linear regression analysis showed that VFA,FIns,HOMA-IR,APN and IL-6 were independent influencing factors of CTRP6,and IL-6 was an independent influencing factor of Irisin.Logistic regression analysis showed that HOMA-IR,CTRP6 and Irisin were independent predictors of T2DM.Receiver operating characteristic curve analysis showed that the area under the curve(AUC)of serum CTRP6 for predicting T2DM was 0.795,the AUC of serum Irisin for predicting T2DM was 0.669,and the AUC of the combination predicting T2DM was 0.832.Conclusion Serum CTRP6 and Irisin are closely related to T2DM and have high predictive value for T2DM.
基金supported in part by the National Key R&D Program of China(No.2022YFC3401800)National Natural Science Foundation of China(32070264)+5 种基金Shandong Provincial Natural Science Foundation(ZR2019ZD48)the Strategic Priority Research Program of CAS(XDA26050402)the Science&Technology Specific Project in Agricultural High-tech Industrial Demonstration Area of the Yellow River Delta(2022SZX12)the Innovation Center for Academicians of Hainan Provincethe Specific Research Fund of the Innovation Center for Academicians of Hainan Province(No.YSPTZX202309)supported in part by NASA Cooperative Agreement 80NSSC21M0355。
文摘Halorhodospira(Hlr.)halochloris is a triply extremophilic phototrophic purple sulfur bacterium,as it is thermophilic,alkaliphilic,and extremely halophilic.The light-harvesting-reaction center(LH1–RC)core complex of this bacterium displays an LH1-Q_(y)transition at 1,016 nm,which is the lowest-energy wavelength absorption among all known phototrophs.Here we report the cryo-EM structure of the LH1–RC at 2.42?resolution.The LH1 complex forms a tricyclic ring structure composed of 16αβγ-polypeptides and oneαβ-heterodimer around the RC.From the cryo-EM density map,two previously unrecognized integral membrane proteins,referred to as protein G and protein Q,were identified.Both of these proteins are single transmembrane-spanning helices located between the LH1 ring and the RC Lsubunit and are absent from the LH1–RC complexes of all other purple bacteria of which the structures have been determined so far.Besides bacteriochlorophyll b molecules(B1020)located on the periplasmic side of the Hlr.halochloris membrane,there are also two arrays of bacteriochlorophyll b molecules(B800 and B820)located on the cytoplasmic side.Only a single copy of a carotenoid(lycopene)was resolved in the Hlr.halochloris LH1–α3β3 and this was positioned within the complex.The potential quinone channel should be the space between the LH1–α3β3 that accommodates the single lycopene but does not contain aγ-polypeptide,B800 and B820.Our results provide a structural explanation for the unusual Q_(y)red shift and carotenoid absorption in the Hlr.halochloris spectrum and reveal new insights into photosynthetic mechanisms employed by a species that thrives under the harshest conditions of any phototrophic microorganism known.
文摘Objective To explore the mechanism of gypenosides(GPs) preventing and treating atherosclerosis (AS)through Bcl2L12-mediated apoptosis pathway.Methods ApoE^(-/-) mice were selected and randomly divided into model group and GPs group (high-fat feeding for 12weeks),and C57BL/6J mice were used as normal group,with 8 mice in each group.
文摘Objective Based on the Forkhead Box P3(Foxp3)/Retinoic acid-related orphan receptorγt (RORγt)immune imbalance mechanism,to analyze the changes of related cytokines and intestinal flora,and to explore the mechanism of Xuanbai Chengqi Decoction (XBCQD) on lung and intestinal injury caused by influenza virus (Ⅳ)and Streptococcus pneumoniae (SPN) co-infection.
文摘Objective To observe the effects of electroacupuncture(EA) at"Jiaji"(EX-B 2) combined with neurodynamic mobilization (NM) on the cross-sectional area of the gastrocnemius muscle fibers after sciatic nerve injury in rabbits,and the expression of nuclear factor-κB (NF-κB) and muscle-specific ring-finger protein 1 (MuRF1).
文摘Objective To explore the clinical differences among patients with chronic heart failure(CHF)with different Chinese medicine(CM)syndromes,and to identify the influencing factors of yang qi depletion and blood stasis syndrome.Methods Totally 179 patients with CHF was conducted in the Department of Integrative Cardiology,China-Japan Friendship Hospital,including 58 cases of qi deficiency and blood stasis syndrome(QBS),31 cases of qi and,yin deficiency and blood stasis syndrome(QYBS),and 90 cases of yang qi depletion and blood stasis syndrome(YBS).
文摘Objective To evaluate the efficacy,anticoagulant role,and effect on aspirin resistance(AR)of Longchai Jiangxue Formula(LCJX)intreating essential thrombocythemia(ET).Methods Seventy-two patients with ET met the inclusion criteria at the Department of Hematology,Xiyuan Hospital,China Academy of Chinese Medical Sciences,from October 2021 to December 2022,and were assigned to the control group and the observation group,with 36 cases in each group by using the method of randomized numerical table.
文摘Objective To explore the influence of family history of diabetes and central obesity on prediabetes (Pre-DM)and their interaction.Methods Based on the REACTION study during August December 2011 in Dalian,2 587 individuals aged≥40 with normal blood glucose (BG)were divided into newly diagnosed Pre-DM (n=522) and BG normal group(NC,n=2 065) during follow-up.
文摘Objective To evaluate the effects of Qingda Granules (QDG) on office blood pressure (OBP) and the anxiety score in patients with grade 1 hypertension with different levels of anxiety.Methods A randomized,multicenter,double-blinded,non-inferiority clinical trial design was adopted.A total of 552 patients with grade 1hypertension were randomly assigned to the treatment group(276 cases) and the control group (276 cases).
文摘Objective To observe the effects of Modified Chaihu Shugan Formula (MCSF) on the behavior of epileptic mice and their regulatory effects on long noncoding RNAUCA1(lncRNA-UCA1),microRNA-187(miR-187) and recombinant mitogen activated protein kinase 8(MAPK8).Methods Totally 80 mice were randomly divided into normal group,model group (pilocarpine hydrochloride 180 mg/kg).
文摘Objective To investigate the inhibitory effect of Gandou Decoction combined with penicillamine on cuproptosis in the liver of toxic milk (TX) mice,which serve as a model for Wilson's disease (WD).Methods Using dilute lethal (DL) mice as the normal control group,and TX mice were randomly divided into model group,Gandou Decoction group,penicillamine group,and Gandou Decoction combined with penicillamine group,with 8 mice in each group.
文摘Objective To evaluate proximal gastric function in patients with functional dyspepsia(FD)met RomeⅢcriteria and its subtypes.Methods Thirty FD patients were enrolled,including 15 patients with postprandial distress syndrome(PDS)and 15 patients with epigastric pain syndrome(EPS).A total of 30 healthy volunteers were recruited as control.All the subjects received barostat examination.Minimal distending pressure(MDP),
文摘Objective To observe the the therapeutic efficacy of Dahuang Fuzi Decoction in patients with acute respiratory distress syndrome(ARDS)and severe acute pancreatitis(SAP).Methods A prospective,multi-center。
文摘Objective The pathogenesis of irritable bowel syndrome (IBS) ,a functional gastrointestinal disorder,is poorly understood.Treatment with Chinese medicine and pharmacy (CMP) is superior to treatment with Western medicine (WM) .Therefore,we aimed to
文摘Objective To investigate the morphological changes of the brainstem in patients with Alzheimer's disease(AD)and their relationship with hippocampal morphological changes.Methods Sixty AD patients(AD group)and sixty age-and gender-matched normal elderly(normal control group)were selected from the Alzheimer's Disease Neuroimaging Initiative(ADNI)database.The hippocampus and the brainstem of each subject were segmented and their normalized volumes were calculated.According to the hippocampal volume standard value(Z-score),AD patients were divided into two subgroups(hippocampal atrophy group(n=51)and hippocampal spared group(n=9)).A voxel-based morphology(VBM)study was also performed to investigate the morphological differences of the brainstem between the normal control group and the AD group,as well as between the AD subgroups.Results Compared with the normal control group,the brainstem volume in the AD group decreased significantly(16741.31±1739.11 vs 15609.67±1451.60,t=3.870,P=0.001).In the AD subgroups,the volume of the brainstem in the hippocampal atrophy group was significantly smaller than that in the hippocampal spared group(16556.30±1514.86 vs 15442.62±1389.05,t=2.189,P=0.033).Pearson correlation analysis showed that Mini-Mental State Examination scores were positively correlated with the hippocampal and the brainstem volumes(r=0.590,P<0.01;r=0.234,P<0.05),and there was a positive correlation between the hippocampal and the brainstem volume changes in patients with AD(r=0.315,P=0.014).VBM results showed that both the bilateral midbrain and the bilateral pons in the AD group had significant atrophy compared with the normal control group(P<0.05).In the AD subgroups,the bilateral midbrain and the left pons in the hippocampal atrophy group were significantly atrophied compared with the hippocampal spared group(P<0.05).Conclusion The brainstem shows morphological changes in patients with AD,and the morphological changes of the brainstem in AD patients with different degrees of hippocampal atrophy are different,indicating the morphological changes of the hippocampus and the brainstem may have an interrelated relationship.
文摘Objective To study the changes of serum levels of Irisin and Galanin in patients with type 2 diabetes mellitus and obesity. Methods A total of 182 patients with type 2 diabetes (T2DM) hospitalized in Endocrinology and Metabolism Department in Baoding First Center Hospital were enrolled in this study. All the patients were divided into three groups according to their BMI: normal weight group (NW), diabetic overweight group (OW) and diabetes and obesity group (OB).
