Graduate student recruitment publicity is a very important link in graduate student recruitment,the quality of students directly affects the quality of graduate education.Taking Harbin Institute of Technology(Weihai)a...Graduate student recruitment publicity is a very important link in graduate student recruitment,the quality of students directly affects the quality of graduate education.Taking Harbin Institute of Technology(Weihai)as the research object,this paper analyzes the internal and external factors affecting the improvement of graduate student quality in the branch campus,and carries out the corresponding countermeasures,puts forward the propaganda strategy of all-round research and recruitment,and effectively improves the quality of graduate student in the branch campus.展开更多
Accelerating the development of students is the basic goal of postgraduate talent cultivation.The final research results,employment situation and satisfaction of postgraduate students with school education are more im...Accelerating the development of students is the basic goal of postgraduate talent cultivation.The final research results,employment situation and satisfaction of postgraduate students with school education are more important indicators of the quality of talent cultivation in a university.For having a deeper understanding of the satisfaction of postgraduates in Harbin Institute of Technology(Weihai)in terms of motivation,tutor situation,management service and employment situation,a questionnaire survey was conducted on postgraduates.The survey results show that the overall satisfaction of postgraduates is high.In terms of studying motivation,most postgraduates think that their majors are more related to employment;in terms of professors,most of them can get along well with their professors and learn from the advantages of their professors;in terms of school management,they respond well to the"library",but think that the"dormitory"and"canteen"need further improvement;in terms of employment,most of postgraduates choose to be employed,while a few of them choose to further their studies,most of which have applied to study in domestic or foreign universities.展开更多
BACKGROUND Non-invasive evaluation for liver fibrosis is clinically important,especially in patients with undetectable hepatitis B virus(HBV)DNA treated with nucleoside analogs.AIM To clarify the monitoring power of h...BACKGROUND Non-invasive evaluation for liver fibrosis is clinically important,especially in patients with undetectable hepatitis B virus(HBV)DNA treated with nucleoside analogs.AIM To clarify the monitoring power of hepatitis B core-related antigen(HBcrAg)for hepatic histologic changes in patients with chronic hepatitis B(CHB)treated with entecavir.METHODS This prospective multicenter study used multiple ordinal and multivariate logistics regression analysis to assess variables associated with Ishak fibrosis score and regression for fibrosis regression,respectively,in 403 CHB patients,including 374 with entecavir for 72 weeks(291 underwent paired liver biopsy)and 29 as controls.RESULTS Level of HBcrAg correlated negatively with liver fibrosis staging(γ=-0.357,P<0.001)in hepatitis B e antigen(HBeAg)-positive patients,and positively with liver fibrosis staging in HBeAg-negative patients.Higher HBcrAg concentration was associated with younger age,HBeAg positive status,high HBV DNA loads,high level of hepatitis B surface antigen(HBsAg)and higher necroinflammation,but not with HBV genotype.Serum concentration of HBcrAg,basal core promoter/precore(BCP/PC)mutant,quantitation of HBsAg(qHBsAg)and platelet counts were independently associated with Ishak fibrosis score on multiple ordinal regression.HBV DNA was undetectable in 88.37%of patients treated with entecavir at week 72,while their level of HBcrAg was still detectable.A greater reduction in post-treatment HBcrAg concentration was associated with the regression of hepatic fibrosis and histological improvement.HBcrAg concentration>6.33 log IU/mL at baseline and logarithmic reduction>1.03 log IU/mL at week 72 were associated with a higher chance of regression of liver fibrosis and histological improvement,respectively.CONCLUSION HBcrAg level is associated with liver fibrosis progression.HBcrAg is an excellent monitor of hepatic histological changes,especially in CHB patients treated with nucleoside analogs.展开更多
The development of GPS(Global Positioning System) technology has led to increasingly widely and successful applications of GPS surveys for monitoring crustal movements. However, multi-period GPS survey solutions have ...The development of GPS(Global Positioning System) technology has led to increasingly widely and successful applications of GPS surveys for monitoring crustal movements. However, multi-period GPS survey solutions have not been applied in monitoring vertical crustal movements with normal backgrounds. In this paper, we carried out a comparative study on the vertical deformation of the comprehensive profile of the cross-fault zone in Shanyin, Shanxi province, China, based on GPS and precise leveling observation data for multiple time periods. The vertical deformation rates observed with repeating GPS survey are obviously different(over 20 mm/y at some sites) from those with repeating leveling survey within a relatively short period. However, the deviations in the vertical displacement between GPS and leveling in a long-term survey(over three years) showed good consistency at 3-4 mm/y at most sites, on GPS forced offset surveying and fixed survey instruments in a long-term survey(over three years). Therefore, GPS vertical displacement results can be applied to the study of vertical crustal movements.展开更多
A new class of support structures, called Periodic Structures, is introduced in this paper as a viable means for isolating the vibration transmitted from the sea waves to offshore platform structures through its legs....A new class of support structures, called Periodic Structures, is introduced in this paper as a viable means for isolating the vibration transmitted from the sea waves to offshore platform structures through its legs. A passive approach to reduce transmitted vibration generated by waves is presented. The approach utilizes the property of periodic structural components that create stop and pass bands. The stop band regions can be tailored to correspond to regions of the frequency spectra that contain harmonics of the wave frequency, attenuating the response in those regions. A periodic structural component is comprised of a repeating array of cells, which are themselves an assembly of elements. The elements may have differing material properties as well as geometric variations. For the purpose of this research, only geometric and material variations are considered and each cell is assumed to be identical. A periodic leg is designed in order to reduce transmitted vibration of sea waves. The effectiveness of the periodicity on the vibration levels of platform will be demonstrated theoretically. The theory governing the operation of this class of periodic structures is introduced using the transfer matrix method. The unique filtering characteristics of periodic structures are demonstrated as functions of their design parameters for structures with geometrical and material discontinuities, and determine the propagation factor by using the spectral finite element analysis and the effectiveness of design on the leg structure by changing the ratio of step length and area interface between the materials is demonstrated in order to find the propagation factor and frequency response.展开更多
BACKGROUND Hepatic inflammatory myofibroblastic tumor(HIMT)is a rare type of hepatic tumor.It is always misdiagnosed and mistreated because it is primarily found with no obvious specific manifestation,and its imaging ...BACKGROUND Hepatic inflammatory myofibroblastic tumor(HIMT)is a rare type of hepatic tumor.It is always misdiagnosed and mistreated because it is primarily found with no obvious specific manifestation,and its imaging findings are diverse.CASE SUMMARY Here,we report a case of HIMT that was initially diagnosed as liver malignancy but was confirmed as HIMT by histopathology after hepatectomy.Mostly,HIMTs are infiltrated with plasma cells and stain positively for anaplastic lymphoma kinase on immunohistochemistry as well as for some other kinases.CONCLUSION HIMT can be treated with single nonsteroidal anti-inflammatory drugs and without surgery when it is diagnosed accurately.Because the etiology of HIMT is unknown and the diagnosis is difficult,the pathogenesis and clinical process need to be further studied.展开更多
Laparoscopic cholecystectomy(LC)has gradually become the first choice for the treatment of cholecystolithiasis in recent years.Iatrogenic bile duct injury(IBDI)is an important clinical problem in LC.The anatomical var...Laparoscopic cholecystectomy(LC)has gradually become the first choice for the treatment of cholecystolithiasis in recent years.Iatrogenic bile duct injury(IBDI)is an important clinical problem in LC.The anatomical variation of the cystic duct increases the probability of IBDI and the difficulty of operation.We present a case of a 44-year-old male with a anatomical variation of the cystic duct complicated with cholecystolithiasis and choledocholithiasis,who successfully underwent choledocholithotomy,choledochoscopic exploration and T-tube drainage surgery.The patient recovered well and was discharged home on postoperative day 10.The T-tube was removed at 1 month postoperatively after cholangiography examination of no choledocholithiasis left.展开更多
The diagnosis and recognition of male osteoporosis is still insufficient.The male patients with low-energy fracture were less evaluated and treated for osteoporosis.The risk of osteoporotic fracture in elderly men may...The diagnosis and recognition of male osteoporosis is still insufficient.The male patients with low-energy fracture were less evaluated and treated for osteoporosis.The risk of osteoporotic fracture in elderly men may be between 13%and 25%.With the extension of men’s life,the risk of fracture increases,which makes the management of men with fracture risk challenging.A consensus is emerging on targeted treatment guidelines for male osteoporosis,especially for elderly patients with high fracture risk.This paper aims to seek evidence through literature review,and put forward the most effective clinical strategies and schemes for the diagnosis and treatment of senile osteoporosis,so as to provide some theoretical guidance for clinical practice.展开更多
Morphine belongs to opioid analgesics,which acts on the central nervous system.It can improve emotional responses such as anxiety,tension,and fear caused by pain and relieve it.Morphine had been widely used in the tre...Morphine belongs to opioid analgesics,which acts on the central nervous system.It can improve emotional responses such as anxiety,tension,and fear caused by pain and relieve it.Morphine had been widely used in the treatment of cancer-related pain.However,a series of opioid-associated adverse effects including opioid-induced respiratory depression were reported in clinical practice.Here,we reported a unique patient diagnosed with lung cancer,who underwent respiratory depression resulting from oral administration of ten milligram of morphine and was successfully resuscitated by naloxone.A literature review is then performed to analyze this rare condition.展开更多
The contact form of rock-concrete has a crucial influence on the failure characteristics of the stability of rock-concrete engineering.To study the influence of contact surface on the mechanical properties of rock-con...The contact form of rock-concrete has a crucial influence on the failure characteristics of the stability of rock-concrete engineering.To study the influence of contact surface on the mechanical properties of rock-concrete composite specimens under compressive loads,the two different contact forms of rock-concrete composite specimens are designed,the mechanical properties of these two different specimens are analyzed under triaxial compressive condition,and analysis comparison on the stress-strain curves and failure forms of the two specimens is carried out.The influence of contact surface constraint on the mechanical properties of rock-concrete composite specimens is obtained.Results show that the stress and strain of rock-concrete composite specimens with contact surface constraint are obviously higher than those without.Averagely,compared with composite specimens without the contact surface,the existence of contact surface constraint can increase the axial peak stress of composite specimens by 24%and the axial peak strain by 16%.According to the characteristics of the fracture surface,the theory of microcrack development is used to explain the contact surface constraint of rock-concrete composite specimens,which explains the difference of mechanical properties between the two rock-concrete composite specimens in the experiment.Research results cannot only enrich the research content of the mechanics of rock contact,but also can serve as a valuable reference for the understanding of the corresponding mechanics mechanism of other similar composite specimens.展开更多
microRNAs(miRNAs)are a class of non-coding functional small RNA composed of 21e23 nucleotides,having multiple associations with liver fibrosis.Fibrosis-associated miRNAs are roughly classified into pro-fibrosis or ant...microRNAs(miRNAs)are a class of non-coding functional small RNA composed of 21e23 nucleotides,having multiple associations with liver fibrosis.Fibrosis-associated miRNAs are roughly classified into pro-fibrosis or anti-fibrosis types.The former is capable of activating hepatic stellate cells(HSCs)by modulating pro-fibrotic signaling pathways,mainly including TGF-b/SMAD,WNT/b-catenin,and Hedgehog;the latter is responsible for maintenance of the quiescent phenotype of normal HSCs,phenotypic reversion of activated HSCs(aHSCs),inhibition of HSCs proliferation and suppression of the extracellular matrix-associated gene expression.Moreover,several miRNAs are involved in regulation of liver fibrosis via alternative mechanisms,such as interacting between hepatocytes and other liver cells via exosomes and increasing autophagy of aHSCs.Thus,understanding the role of these miRNAs may provide new avenues for the development of novel interventions against hepatic fibrosis.展开更多
基金This research was supported by Postgraduate Education and Teaching Reform Project of Shandong Province(SDYJG21018)Postgraduate Education and Teaching Reform Project of Harbin Institute of Technology at Weihai(WH2019002)Postgraduate Education and Teaching Reform Project of Harbin Institute of Technology(21HX1001).
文摘Graduate student recruitment publicity is a very important link in graduate student recruitment,the quality of students directly affects the quality of graduate education.Taking Harbin Institute of Technology(Weihai)as the research object,this paper analyzes the internal and external factors affecting the improvement of graduate student quality in the branch campus,and carries out the corresponding countermeasures,puts forward the propaganda strategy of all-round research and recruitment,and effectively improves the quality of graduate student in the branch campus.
基金was supported by Postgraduate Education and Teaching Reform Project of Shandong Province(SDYJG21018)Postgraduate Education and Teaching Reform Project of Harbin Institute of Technology at Weihai(WH2019002)Postgraduate Education and Teaching Reform Project of Harbin Institute of Technology(21HX1001).
文摘Accelerating the development of students is the basic goal of postgraduate talent cultivation.The final research results,employment situation and satisfaction of postgraduate students with school education are more important indicators of the quality of talent cultivation in a university.For having a deeper understanding of the satisfaction of postgraduates in Harbin Institute of Technology(Weihai)in terms of motivation,tutor situation,management service and employment situation,a questionnaire survey was conducted on postgraduates.The survey results show that the overall satisfaction of postgraduates is high.In terms of studying motivation,most postgraduates think that their majors are more related to employment;in terms of professors,most of them can get along well with their professors and learn from the advantages of their professors;in terms of school management,they respond well to the"library",but think that the"dormitory"and"canteen"need further improvement;in terms of employment,most of postgraduates choose to be employed,while a few of them choose to further their studies,most of which have applied to study in domestic or foreign universities.
基金Supported by Chinese Ministry of Science and Technology Grants the Major Science and Technology Special Project Fund Scheme,No.2013ZX10005002Beijing the Special Clinical Application Research and Translational Grants,No.Z151100004015221
文摘BACKGROUND Non-invasive evaluation for liver fibrosis is clinically important,especially in patients with undetectable hepatitis B virus(HBV)DNA treated with nucleoside analogs.AIM To clarify the monitoring power of hepatitis B core-related antigen(HBcrAg)for hepatic histologic changes in patients with chronic hepatitis B(CHB)treated with entecavir.METHODS This prospective multicenter study used multiple ordinal and multivariate logistics regression analysis to assess variables associated with Ishak fibrosis score and regression for fibrosis regression,respectively,in 403 CHB patients,including 374 with entecavir for 72 weeks(291 underwent paired liver biopsy)and 29 as controls.RESULTS Level of HBcrAg correlated negatively with liver fibrosis staging(γ=-0.357,P<0.001)in hepatitis B e antigen(HBeAg)-positive patients,and positively with liver fibrosis staging in HBeAg-negative patients.Higher HBcrAg concentration was associated with younger age,HBeAg positive status,high HBV DNA loads,high level of hepatitis B surface antigen(HBsAg)and higher necroinflammation,but not with HBV genotype.Serum concentration of HBcrAg,basal core promoter/precore(BCP/PC)mutant,quantitation of HBsAg(qHBsAg)and platelet counts were independently associated with Ishak fibrosis score on multiple ordinal regression.HBV DNA was undetectable in 88.37%of patients treated with entecavir at week 72,while their level of HBcrAg was still detectable.A greater reduction in post-treatment HBcrAg concentration was associated with the regression of hepatic fibrosis and histological improvement.HBcrAg concentration>6.33 log IU/mL at baseline and logarithmic reduction>1.03 log IU/mL at week 72 were associated with a higher chance of regression of liver fibrosis and histological improvement,respectively.CONCLUSION HBcrAg level is associated with liver fibrosis progression.HBcrAg is an excellent monitor of hepatic histological changes,especially in CHB patients treated with nucleoside analogs.
基金supported by the China National Special Fund for Earthquake Scientific Research in Public Interest(201508009)
文摘The development of GPS(Global Positioning System) technology has led to increasingly widely and successful applications of GPS surveys for monitoring crustal movements. However, multi-period GPS survey solutions have not been applied in monitoring vertical crustal movements with normal backgrounds. In this paper, we carried out a comparative study on the vertical deformation of the comprehensive profile of the cross-fault zone in Shanyin, Shanxi province, China, based on GPS and precise leveling observation data for multiple time periods. The vertical deformation rates observed with repeating GPS survey are obviously different(over 20 mm/y at some sites) from those with repeating leveling survey within a relatively short period. However, the deviations in the vertical displacement between GPS and leveling in a long-term survey(over three years) showed good consistency at 3-4 mm/y at most sites, on GPS forced offset surveying and fixed survey instruments in a long-term survey(over three years). Therefore, GPS vertical displacement results can be applied to the study of vertical crustal movements.
文摘A new class of support structures, called Periodic Structures, is introduced in this paper as a viable means for isolating the vibration transmitted from the sea waves to offshore platform structures through its legs. A passive approach to reduce transmitted vibration generated by waves is presented. The approach utilizes the property of periodic structural components that create stop and pass bands. The stop band regions can be tailored to correspond to regions of the frequency spectra that contain harmonics of the wave frequency, attenuating the response in those regions. A periodic structural component is comprised of a repeating array of cells, which are themselves an assembly of elements. The elements may have differing material properties as well as geometric variations. For the purpose of this research, only geometric and material variations are considered and each cell is assumed to be identical. A periodic leg is designed in order to reduce transmitted vibration of sea waves. The effectiveness of the periodicity on the vibration levels of platform will be demonstrated theoretically. The theory governing the operation of this class of periodic structures is introduced using the transfer matrix method. The unique filtering characteristics of periodic structures are demonstrated as functions of their design parameters for structures with geometrical and material discontinuities, and determine the propagation factor by using the spectral finite element analysis and the effectiveness of design on the leg structure by changing the ratio of step length and area interface between the materials is demonstrated in order to find the propagation factor and frequency response.
基金Supported by Shandong Provincial Natural Science Foundation of China,No.ZR2021MH033Postgraduates Foundation of Linyi People’s Hospital(Tong Meng).
文摘BACKGROUND Hepatic inflammatory myofibroblastic tumor(HIMT)is a rare type of hepatic tumor.It is always misdiagnosed and mistreated because it is primarily found with no obvious specific manifestation,and its imaging findings are diverse.CASE SUMMARY Here,we report a case of HIMT that was initially diagnosed as liver malignancy but was confirmed as HIMT by histopathology after hepatectomy.Mostly,HIMTs are infiltrated with plasma cells and stain positively for anaplastic lymphoma kinase on immunohistochemistry as well as for some other kinases.CONCLUSION HIMT can be treated with single nonsteroidal anti-inflammatory drugs and without surgery when it is diagnosed accurately.Because the etiology of HIMT is unknown and the diagnosis is difficult,the pathogenesis and clinical process need to be further studied.
基金supported by the Science and Technology Foundation of Shandong Province(ZR2021MH033)China Postdoctoral Science Foundation(2018M632679).
文摘Laparoscopic cholecystectomy(LC)has gradually become the first choice for the treatment of cholecystolithiasis in recent years.Iatrogenic bile duct injury(IBDI)is an important clinical problem in LC.The anatomical variation of the cystic duct increases the probability of IBDI and the difficulty of operation.We present a case of a 44-year-old male with a anatomical variation of the cystic duct complicated with cholecystolithiasis and choledocholithiasis,who successfully underwent choledocholithotomy,choledochoscopic exploration and T-tube drainage surgery.The patient recovered well and was discharged home on postoperative day 10.The T-tube was removed at 1 month postoperatively after cholangiography examination of no choledocholithiasis left.
文摘The diagnosis and recognition of male osteoporosis is still insufficient.The male patients with low-energy fracture were less evaluated and treated for osteoporosis.The risk of osteoporotic fracture in elderly men may be between 13%and 25%.With the extension of men’s life,the risk of fracture increases,which makes the management of men with fracture risk challenging.A consensus is emerging on targeted treatment guidelines for male osteoporosis,especially for elderly patients with high fracture risk.This paper aims to seek evidence through literature review,and put forward the most effective clinical strategies and schemes for the diagnosis and treatment of senile osteoporosis,so as to provide some theoretical guidance for clinical practice.
文摘Morphine belongs to opioid analgesics,which acts on the central nervous system.It can improve emotional responses such as anxiety,tension,and fear caused by pain and relieve it.Morphine had been widely used in the treatment of cancer-related pain.However,a series of opioid-associated adverse effects including opioid-induced respiratory depression were reported in clinical practice.Here,we reported a unique patient diagnosed with lung cancer,who underwent respiratory depression resulting from oral administration of ten milligram of morphine and was successfully resuscitated by naloxone.A literature review is then performed to analyze this rare condition.
基金This study was partially supported by the National Natural Science Foundation of China(Grant Nos.41302223,51908097)Science and Technology Plan Projects of Municipal Administration of State Land,Resources and Housing,Chongqing Municipal Government(No.KJ-2015047)+3 种基金Chongqing No.3 Colleges and Universities Youth Backbone Teachers Funding Plans and Chongqing Research Program of Basic Research and Frontier Technology(Nos.cstc2016jcyjA0074,cstc2016jcyjA0933,cstc2015jcyjA90012,cstc2019jcyj-msxmX0258)Scientific and Technological Research Program of Chongqing Municipal Education Commission(Nos.KJ1713327,KJ1600532)The Key Laboratory of Well Stability and Fluid&Rock Mechanics in Oil and Gas Reservoir of Shaanxi Province,Xi'an Shiyou University(No.FRM 20190201002)Chongqing University of Science and Technology Graduate Student Science and Technology Innovation Program(No.YKJCX1720601).
文摘The contact form of rock-concrete has a crucial influence on the failure characteristics of the stability of rock-concrete engineering.To study the influence of contact surface on the mechanical properties of rock-concrete composite specimens under compressive loads,the two different contact forms of rock-concrete composite specimens are designed,the mechanical properties of these two different specimens are analyzed under triaxial compressive condition,and analysis comparison on the stress-strain curves and failure forms of the two specimens is carried out.The influence of contact surface constraint on the mechanical properties of rock-concrete composite specimens is obtained.Results show that the stress and strain of rock-concrete composite specimens with contact surface constraint are obviously higher than those without.Averagely,compared with composite specimens without the contact surface,the existence of contact surface constraint can increase the axial peak stress of composite specimens by 24%and the axial peak strain by 16%.According to the characteristics of the fracture surface,the theory of microcrack development is used to explain the contact surface constraint of rock-concrete composite specimens,which explains the difference of mechanical properties between the two rock-concrete composite specimens in the experiment.Research results cannot only enrich the research content of the mechanics of rock contact,but also can serve as a valuable reference for the understanding of the corresponding mechanics mechanism of other similar composite specimens.
基金supported by grants from the National Natural Science Foundation of China(No.32072889,U1703104)Key R&D Program of Zhejiang Province(China)(No.2019C02052)Scientific Research and Development Talent Fund of Zhejiang Agriculture and Forestry University,China(No.2021LFR038).
文摘microRNAs(miRNAs)are a class of non-coding functional small RNA composed of 21e23 nucleotides,having multiple associations with liver fibrosis.Fibrosis-associated miRNAs are roughly classified into pro-fibrosis or anti-fibrosis types.The former is capable of activating hepatic stellate cells(HSCs)by modulating pro-fibrotic signaling pathways,mainly including TGF-b/SMAD,WNT/b-catenin,and Hedgehog;the latter is responsible for maintenance of the quiescent phenotype of normal HSCs,phenotypic reversion of activated HSCs(aHSCs),inhibition of HSCs proliferation and suppression of the extracellular matrix-associated gene expression.Moreover,several miRNAs are involved in regulation of liver fibrosis via alternative mechanisms,such as interacting between hepatocytes and other liver cells via exosomes and increasing autophagy of aHSCs.Thus,understanding the role of these miRNAs may provide new avenues for the development of novel interventions against hepatic fibrosis.
