In an increasingly complex and interconnected world,where the pace of change is accelerating,governments know that they must re-invent the ways they operate.Governments need to develop partnerships,use innovation,lead...In an increasingly complex and interconnected world,where the pace of change is accelerating,governments know that they must re-invent the ways they operate.Governments need to develop partnerships,use innovation,leadership,and above all,employ skilled workforce to face the challenge of managing in uncertainty and become more agile in its operations.Therefore,agile government is the new shape of government for the new millennium where government must be responsive,flexible,creative,and attuned.One of the key elements of agile government is the right human resources.The aim of this practitioners’paper is to explore how human resources management(HRM)can offer tools needed by policymakers to ensure agility in government operations.This includes attracting,recruiting,and developing workforce to meet the ever-changing priorities.Recruitment,performance management,and employee retention among other tools are necessary for public sector to ensure more agility,while developing agile governance and policies.展开更多
The existing literature simply concludes that the irrational behaviors of local people and natural factors are the major reasons for overuse of groundwater. Using the OLS and ARIMA (BJ) Statistical Methods and Trend A...The existing literature simply concludes that the irrational behaviors of local people and natural factors are the major reasons for overuse of groundwater. Using the OLS and ARIMA (BJ) Statistical Methods and Trend Analyses, this article finds that government policy, as measured by four proxy variables, is a very important factor that strongly influences the overuse of groundwater at the collective level. This means the government is a very important actor in the game of groundwater usage. Although these findings cannot clearly separate government effects from local effects, using a Trend Analysis, they reveal that these significant effects are strictly consistent with variations in government policy. Moreover, they show that government policy effective at the county level strongly impacts the overuse of ground-water by influencing the behavior of the local people and that policy at the operative level impacts four policy domains: population, cultivated land, water assignments and peasant income.展开更多
Hong Kong has a long history with its high efficiency and clean and self-disciplined government.Within the past over 20 years,different social development trend has occurred in Hong Kong.The article observed the relat...Hong Kong has a long history with its high efficiency and clean and self-disciplined government.Within the past over 20 years,different social development trend has occurred in Hong Kong.The article observed the relationship between political trust from residence and public service efficiency of government in Hong Kong from 1992 to 2015 and found that the value of public service efficiency has a significant effect on political trust in Hong Kong government,the higher the efficiency of public services,the higher the political trust.The author tried to find the path for the Hong Kong government to improve its public service quality and efficiency after testifying the positive correlation between public service efficiency and residential political trust with empirical analysis.展开更多
International non-governmental organizations were among the first international actors that responded to the emer- gence of AIDS crisis in China. Since 1994, the number of international non-governmental organizations ...International non-governmental organizations were among the first international actors that responded to the emer- gence of AIDS crisis in China. Since 1994, the number of international non-governmental organizations and charitable foundations working in AIDS related issue areas in China has grown steadily and substantially. Despite their organiza- tional differences, most of these non-governmental actors present the characteristics of independent mission, localized practice and diverse working focus. Even though they are constrained by financial and other factors compared with multilateral and bilateral official assistance agencies, they have still played a unique role in fighting against AIDS in China as technical experts, public educators, and civil society supporters.展开更多
Improper prescribing habits and inappropriate drug use lead to serious health and economic consequences. This study was undertaken to evaluate drug utilization services and prescription patterns of homeopathic doctors...Improper prescribing habits and inappropriate drug use lead to serious health and economic consequences. This study was undertaken to evaluate drug utilization services and prescription patterns of homeopathic doctors in a government homeopathic teaching hospital in India. METHODS： No standardized homeopathic drug use indicators are available. The researchers used indicators for health care setting （drug availability）-modified prescribing indicators and patient care indicators, based on World Health Organization＇s core drug use indicators. A cross- sectional, prospective, institutional, observational study of 2-month duration with record analysis was conducted on 600 patients visiting seven different outpatient departments （OPDs） for the first time at Mahesh Bhattacharyya Homeopathic Medical College ＆ Hospital, Howrah, West Bengal, India, using the developed indicators. RESULTS： Overall availability of prescribed drugs was quite satisfactory （92.28%）. Centesimal potencies accounted for the majority of prescriptions （74.76%）. There was a poor record of diagnosis （39.17%） except in the OPDs of Gynecology and Obstetrics （68.48%, P 〈 0.01） and Dermatology （64.58%, P 〈 0.01）. Records of investigational findings and ongoing therapies, if any, were also poor except OPDs of Gynecology and Obstetrics, and Pediatrics. Structure of prescriptions was maintained satisfactorily in all the OPDs. Though tendency of using ＇individualized homeopathy＇ predominated, there also existed the use of ＇polypharmacy＇. Mean consultation time was 5.9 min. Labeling was extremely poor and is an area needing improvement. The prescriptions were highly legible. CONCLUSION： This was a preliminary study, conducted for the first time in homeopathy using newly developed indicators that yield meaningful results. Further studies are necessary in order to evaluate the different factors involved and to plan future interventions to improve the quality of care in healthcare settings.展开更多
Objective: The Okinawa prefectural government conducted enhanced surveillance for the Sixth Worldwide Uchinanchu Festival, with participation of more than 5300 visitors from abroad, many of whom were Okinawan or of Ok...Objective: The Okinawa prefectural government conducted enhanced surveillance for the Sixth Worldwide Uchinanchu Festival, with participation of more than 5300 visitors from abroad, many of whom were Okinawan or of Okinawan descent, for early detection of Zika virus disease and other potential public health threat outbreaks. Method: Enhanced surveillance conducted from 12 October through 13 November involved four surveillance systems, (Nursery) School Absenteeism Surveillance system ((N)SASSy), Prescription Surveillance (PS), and Official Syndromic Surveillance (OSS), each of them operates routinely, in addition to case-based and sentinel surveillance under the Infectious Diseases Control Law as Official National Surveillance of Infectious Diseases (ONSID). This enhanced surveillance was conducted for analysis and evaluation, with intensive information sharing among concerned parties. Result: We performed the enhanced surveillance for 33 days from 12 October through 13 November. Information from enhanced surveillance was analyzed and evaluated, and eventually summarized as a daily report. There has been one rubella case at an elementary school in Okinawa City on 20 October and a measles case at an elementary school in Uruma City on 2 November. Those two cases were registered into (N)SASSy on a timely basis. The public health center investigated them quickly, and the measles case was denied later because symptoms did not satisfy with case definition. Discussion: We regard enhanced surveillance as useful to confirm events that might demand a public health response. Moreover, the related including public health centers or medical institutions confirmed the situation as valuable for the administrative structure. However, because almost all (nursery) schools or pharmacies are closed during successive holidays, outbreaks that occur on such days cannot be recognized on a timely basis. More sensitive surveillance for such days, with better preparations for ambulance transfer and at emergency departments in hospitals remains as a challenge for future work.展开更多
Literature and experimental data relevant to the decision to allow a waiver of in vivo bioequivalence(BE)testing for approval of immediate release(IR)solid dosage forms containing moxifloxacin hydrochloride as the API...Literature and experimental data relevant to the decision to allow a waiver of in vivo bioequivalence(BE)testing for approval of immediate release(IR)solid dosage forms containing moxifloxacin hydrochloride as the API manufactured by the Government Pharmaceutical Organization(GPO)are evaluated.The solubility of moxifloxacin hydrochloride determined by the shake flask method in six different pH mediums(1.2,4.5,5.4,6.4,6.8 and 7.5)was 4.988±0.1962,27.012±0.4138,21.668±0.5165,47.200±0.8095,73.438±1.7310 and 196.475±4.4624 mg/mL,respectively.The Dose/Solubility(D/S)Ratio of the highest strength(400 mg)available in the market of moxifloxacin tablets was 80.192,14.808,18.460,8.475,5.447 and 2.036 mL,respectively.展开更多
Objective:To explore risk factors for the development of pneumothorax in patients with COVID-19 during the second COVID-19 wave at a northern Indian level 2 health facility.Methods:Patients suffering from SARS-CoV-2 i...Objective:To explore risk factors for the development of pneumothorax in patients with COVID-19 during the second COVID-19 wave at a northern Indian level 2 health facility.Methods:Patients suffering from SARS-CoV-2 infection during the second wave of the COVID-19 pandemic in India(January-June 2021)at a tertiary care teaching hospital and level 2 COVID care facility were included.Cases who suffered from SARS-CoV-2 infection but did not develop pneumothorax were selected as matched controls.All details regarding demographics,clinical presentation,treatment,and outcome were recorded in a semi-structured proforma.Results:Eleven patients with COVID-19 developed pneumothorax during the study period and 40 controls were included in the study.Five cases were smokers in comparison to only two in the control group.Type 2 diabetes mellitus was the most common comorbidity among both groups.Median change in C-reactive protein overall for cases and controls were around+14.0 and-41.9 and was statistically significant.Conclusions:Inflammatory markers like C-reactive protein have significant correlations with the development of pneumothorax in COVID-19-infected patients.There is no sex predisposition to develop pneumothorax among patients with COVID-19.展开更多
Objective: This is an audit to evaluate the maternal and perinatal outcome in eclampsia and imminent eclampsia with the management adopted at a tertiary hospital. Methods: During a period of 34 months, from 2003-2007 ...Objective: This is an audit to evaluate the maternal and perinatal outcome in eclampsia and imminent eclampsia with the management adopted at a tertiary hospital. Methods: During a period of 34 months, from 2003-2007 at Government maternity hospital, Osmania medical college, Hyderabad, 666 women with eclampsia and imminent eclampsia were managed. The number of eclampsia and imminent eclampsia (IE) was 532 and 134, respectively. We have analyzed the clinical profile, parity, age, degree of proteinuria, the period of gestation in weeks, the antenatal care, the number of antenatal visits, referrals from other hospitals, the diastolic B.P. at the time of admission, the recurrence of convulsions and the complications. 1) All the cases of eclampsia and IE were managed with magnesium sulphate as an anticonvulsant. 2) Oral nifedipine, IV labetalol, sublingual nifedipine and nitroglycerine infusion were used to control severe hypertension. 3) Prostaglandin E1 (PGE1) was used for induction of labour (IOL), 25 mcg × 4th hrly, vaginal route and 50 mcg for less than 28 weeks gestation, in 290/424 cases of IOL. Other methods of IOL were employed in 134 cases. Results: Eclampsia (n = 532) occurred antepartum in 407 (75.56%), intrapartum in 76 (14.28%), post partum in 46 (8.64%) and intercurrent in 3 (0.5%) patients. The period of gestation was 34 weeks in 340 patients. Induction of labour with misoprostol was done in 290 with vaginal delivery in 235 (81%) and lower segment caesarean section (LSCS) for failed IOL in 55 (19%) and other methods of IOL were used in 134. The total number of deliveries was 656, with vaginal deliveries in 336 (66.46%) patients, ceasarean deliveries in 220 (33.54%) patients. Ten patients died undelivered. Maternal mortality was 17/666—2.55%. Cerebrovascular events were responsible in 13/17 (76.46%) patients, pulmonary embolisim in 2, aspiration pneumonia in one and sepsis in one. The perinatal mortality was 167/582 (28.69%), PNM when birth weight was >1.5 kg was 59/426 (13.84%), intrauterine fetal deaths at admission were 54 (8.5%), there were four sets of twins. Conclusions: 1) More effective measures to control hypertension and routine administration of anticonvulsant, magnesium sulphate to women with eclampsia should be practised from the first referral unit itself. 2) Our caesarean delivery rate of 33.54% in the very high risk cases of eclampsia and imminent eclampsia is very low compared to others. 3) Induction of labour with misoprostol was successful in 81% with consequent reduction in caesarean section rate and morbidity and mortality associated with caesarean deliveries. Misoprostol has proved to be a safe and effective inducing agent in eclampsia. 4) The maternal mortality in our series is 2.55%.展开更多
<b>Introduction:</b> The recent COVID-19 pandemic has prompted concern about the compatibility of IPC guidelines with health care workers, their working practices and behaviours. These guidelines can be di...<b>Introduction:</b> The recent COVID-19 pandemic has prompted concern about the compatibility of IPC guidelines with health care workers, their working practices and behaviours. These guidelines can be difficult and time-consuming to adhere to in practice. By identifying barriers and facilitators to IPC guideline adherence, especially using personal protective equipment (PPE), we can identify focussed strategies that will support health care workers to undertake the IPC measures needed at such a critical time in health care internationally. <b>Material & Methods:</b> This was a cross-sectional study designed during the COVID-19 pandemic management in the South Gujarat region, to analyse the knowledge, attitude and practices of health care workers about their usage of personal protective equipment. A semi-structured questionnaire-based study was prepared, deriving pointers from our previous experience of seasonal flu outbreaks. 225 participants enrolled who were doctors, resident doctors, nurses, lab technicians, ward boys and food distributors. <b>Result:</b> Analysis of the barriers-related questions show good preparedness by the medical institution. Overall we found good knowledge, attitude and practice related to PPE during COVID-19 pandemic management. There are few gaps found in the knowledge of donning of PPE (p-0.0075), N-95 mask related knowledge (p-0.01) and the attitude that PPE use causes discomfort while nursing patients (0.0001).展开更多
Objective:An investigation of an outbreak of measles in a district in Nigeria was initiated following confirmation of the outbreak.The objectives of the study were to assess the size and determine the cause of the out...Objective:An investigation of an outbreak of measles in a district in Nigeria was initiated following confirmation of the outbreak.The objectives of the study were to assess the size and determine the cause of the outbreak. Methods:Visits were made to health facilities and affected communities.Cases were line-listed using specified forms and descriptive epidemiology carried out on collected data.Results:A total of 18 cases and 0 deaths were identified over a period of six weeks.Two of the cases(11%) were 【 9 months of age.The proportion of zero-dose children was 39%.Conclusion:Low herd immunity was suggested as the cause of the outbreak.展开更多
Stroke is a devastating and disabling cerebrovascular disease with some amount of residual deficit leading onto economic loss. Recent Indian studies have shown a stroke prevalence rate of 471.58/100,000 population. Th...Stroke is a devastating and disabling cerebrovascular disease with some amount of residual deficit leading onto economic loss. Recent Indian studies have shown a stroke prevalence rate of 471.58/100,000 population. This study was undertaken to analyse the clinical profile and to arrive at important factors contributing to stroke in 45 years group. This is a descriptive, retrospective cross—sectional study carried out on acute CVA patients, admitted to the I.I.M., RGGGH, Chennai. 150 patients were studied over a period of 3 months in the 2011. 20% of /= 45 years constituted our study population. 18.4% and 22.2% of males and females respectively were young stroke patients. Only 33.3% of patients were brought to the hospital within 6 hours. 90% patients had mild GCS score (>/=13/15) and presented with hemiplegia 76% and 18% had infarct and intracerebral hemorrhage(ICH) respectively. Risk factors: Type A personality (70.7%), Tobacco (60.7%) and Alcohol (44.7%) abuse, Systemic Hypertension (60.7%), Diabetes Mellitus (33.3%), Cardiac disorders (14%). Stroke was seen to be more common in >45 years but still young stroke carries paramount importance due to loss of productive years in these patients. Female predominance was seen in young stroke, with particular reference to puerperal period. Among the comorbid illness systemic hypertension followed by cardiac disorders had important contributing role in young strokes. Most of the patients with infarct and ICH were tobacco and alcohol abusers respectively. A holistic approach encompassing further research in factors involved in young stroke, public awareness, behavioural modification and comorbid medical illness management is the need for the hour.展开更多
Information monopoly of bureaucrats helps them maximize discretionary budget. Public disclosure of budget can alleviate information asymmetry between government and the public and empower public supervision on governm...Information monopoly of bureaucrats helps them maximize discretionary budget. Public disclosure of budget can alleviate information asymmetry between government and the public and empower public supervision on government budget. With information intermediary function and reputational governance function, the media exert a budget intervention effect in the public disclosure of government budget, which further increases the effect of government budget disclosure. This paper investigates how media reports influence "three public expenses"(TPE) budget planning of central government departments by examining media reports on the disclosure of budget and final accounts and using TPE budget as a proxy variable for discretionary budget of bureaucrats. We have reached the following findings:(1) The higher the TPE budget implementation rate, the greater budget growth will be. But this correlation can be restrained by media attention;(2) Different stance of the media may exert different governance effects on TPE budget. Good news about TPE may motivate bureaucrats to restrain the positive impact of TPE budget implementation on budget growth. However, bad news about TPE will exert its budget intervention effect only when administrative governance mechanism intervenes. This study has broadened research on the media's governance effect from the perspective of government budget transparency and verified that under China's unique institutional background, the media may still play a positive role in public sector governance.展开更多
Vaccination is the mainstream measure against coronavirus disease 2019(COVID-19).As of May 2022,more than 80%of the Japanese population has received vaccination doses(1),and booster vaccination programs are in progres...Vaccination is the mainstream measure against coronavirus disease 2019(COVID-19).As of May 2022,more than 80%of the Japanese population has received vaccination doses(1),and booster vaccination programs are in progress.Acute disseminated encephalomyelitis is the most common type of demyelination following vaccinations,and although an increase in neuromyelitis optica spectrum disease(NMOSD)has recently been reported worldwide(2-4),no collective data,especially after newly developed mRNA vaccines against COVID-19,have been reported yet.展开更多
In this paper,an evaluation index system for the coordinated development of regional economy was constructed by considering the aspects of regional development coordination,economic development coordination,economic a...In this paper,an evaluation index system for the coordinated development of regional economy was constructed by considering the aspects of regional development coordination,economic development coordination,economic and social coordination,and resource and environment coordination,which is used to perform comprehensive evaluation of the coordinated development of regional economy.On this basis,the impact of the upgrading of industrial structure,scientific and technological innovation,and government intervention on the coordinated development of regional economy were also investigated.According to the findings of our study,the coordinated development of regional economy in the eastern region was obviously better than that in the central region,while the western region had the lowest coordinated development of regional economy;the upgrading of regional industrial structure promoted the coordinated development of regional economy,while the promoting effect of the scientific and technological innovation on the coordinated development of regional economy were partly achieved by its promotion of the upgrading of industrial structure;the effect of government intervention couldn't be well reflected in the coordination index of regional economy.展开更多
传统企业合作伙伴推荐方法过度依赖技术特征而忽视多维因素影响。本研究旨在探究企业合作关系的多维影响因素及推荐机制,为企业寻找合适合作伙伴和制定有效创新策略提供技术支持。本研究提出一种基于交叉多头对比学习网络(cross-attenti...传统企业合作伙伴推荐方法过度依赖技术特征而忽视多维因素影响。本研究旨在探究企业合作关系的多维影响因素及推荐机制,为企业寻找合适合作伙伴和制定有效创新策略提供技术支持。本研究提出一种基于交叉多头对比学习网络(cross-attention multi-head contrastive network,CAMC-Net)的企业合作伙伴推荐方法,融合企业、专利和政策数据,通过交叉多头注意力机制建模企业关系的双向互补特性,并引入对比学习策略优化企业表示空间分布。以新能源产业为例,在专利IPC(International Patent Classification)分类号为H02P和H10的企业合作数据集上进行验证,CAMC-Net模型在企业关系识别任务上AUC(area under the curve)分别达到0.9425和0.9251,准确率分别为0.8644和0.8387,F1值分别达到0.8707和0.8471,优于基线模型。通过消融实验证明了政策数据与模型组件的有效性。但现有的研究数据主要基于单一领域,未来需探索跨领域企业合作伙伴推荐方法;同时,模型缺乏对多模态数据的考虑,需要探索更高效的多模态特征融合策略。展开更多
This paper researches the overall construction target of government-led urban complex construction projects based on the perspective of sustainable urban development. In order to achieve benefit maximization, the meta...This paper researches the overall construction target of government-led urban complex construction projects based on the perspective of sustainable urban development. In order to achieve benefit maximization, the meta-synthesis management for the government-led urban complex construction project is studied. In order to combine theory and practice, several typical government-led urban complex construction project cases, such as Guangzhou Higher Education Mega Center and Guangzhou International Financial City etc. are examined. These examples point to the feasibility of government-led meta-synthesis management and demonstrate the benefits that can be achieved through this model.展开更多
文摘In an increasingly complex and interconnected world,where the pace of change is accelerating,governments know that they must re-invent the ways they operate.Governments need to develop partnerships,use innovation,leadership,and above all,employ skilled workforce to face the challenge of managing in uncertainty and become more agile in its operations.Therefore,agile government is the new shape of government for the new millennium where government must be responsive,flexible,creative,and attuned.One of the key elements of agile government is the right human resources.The aim of this practitioners’paper is to explore how human resources management(HRM)can offer tools needed by policymakers to ensure agility in government operations.This includes attracting,recruiting,and developing workforce to meet the ever-changing priorities.Recruitment,performance management,and employee retention among other tools are necessary for public sector to ensure more agility,while developing agile governance and policies.
文摘The existing literature simply concludes that the irrational behaviors of local people and natural factors are the major reasons for overuse of groundwater. Using the OLS and ARIMA (BJ) Statistical Methods and Trend Analyses, this article finds that government policy, as measured by four proxy variables, is a very important factor that strongly influences the overuse of groundwater at the collective level. This means the government is a very important actor in the game of groundwater usage. Although these findings cannot clearly separate government effects from local effects, using a Trend Analysis, they reveal that these significant effects are strictly consistent with variations in government policy. Moreover, they show that government policy effective at the county level strongly impacts the overuse of ground-water by influencing the behavior of the local people and that policy at the operative level impacts four policy domains: population, cultivated land, water assignments and peasant income.
基金Our article is a stage achievement of the Project of the 13th Five-year Plan of Education Science of Guangdong Province:“Path to Improve Governance Capacity of Pilot Zone of Shenzhen”(2020GXJK031)the Project of Philosophy&Social of Zhuhai City:“An Investigation on National Identity of University Students from Hong Kong and Macao in Zhuhai”(2019YC052).We appreciate the support from the projects.
文摘Hong Kong has a long history with its high efficiency and clean and self-disciplined government.Within the past over 20 years,different social development trend has occurred in Hong Kong.The article observed the relationship between political trust from residence and public service efficiency of government in Hong Kong from 1992 to 2015 and found that the value of public service efficiency has a significant effect on political trust in Hong Kong government,the higher the efficiency of public services,the higher the political trust.The author tried to find the path for the Hong Kong government to improve its public service quality and efficiency after testifying the positive correlation between public service efficiency and residential political trust with empirical analysis.
文摘International non-governmental organizations were among the first international actors that responded to the emer- gence of AIDS crisis in China. Since 1994, the number of international non-governmental organizations and charitable foundations working in AIDS related issue areas in China has grown steadily and substantially. Despite their organiza- tional differences, most of these non-governmental actors present the characteristics of independent mission, localized practice and diverse working focus. Even though they are constrained by financial and other factors compared with multilateral and bilateral official assistance agencies, they have still played a unique role in fighting against AIDS in China as technical experts, public educators, and civil society supporters.
文摘Improper prescribing habits and inappropriate drug use lead to serious health and economic consequences. This study was undertaken to evaluate drug utilization services and prescription patterns of homeopathic doctors in a government homeopathic teaching hospital in India. METHODS： No standardized homeopathic drug use indicators are available. The researchers used indicators for health care setting （drug availability）-modified prescribing indicators and patient care indicators, based on World Health Organization＇s core drug use indicators. A cross- sectional, prospective, institutional, observational study of 2-month duration with record analysis was conducted on 600 patients visiting seven different outpatient departments （OPDs） for the first time at Mahesh Bhattacharyya Homeopathic Medical College ＆ Hospital, Howrah, West Bengal, India, using the developed indicators. RESULTS： Overall availability of prescribed drugs was quite satisfactory （92.28%）. Centesimal potencies accounted for the majority of prescriptions （74.76%）. There was a poor record of diagnosis （39.17%） except in the OPDs of Gynecology and Obstetrics （68.48%, P 〈 0.01） and Dermatology （64.58%, P 〈 0.01）. Records of investigational findings and ongoing therapies, if any, were also poor except OPDs of Gynecology and Obstetrics, and Pediatrics. Structure of prescriptions was maintained satisfactorily in all the OPDs. Though tendency of using ＇individualized homeopathy＇ predominated, there also existed the use of ＇polypharmacy＇. Mean consultation time was 5.9 min. Labeling was extremely poor and is an area needing improvement. The prescriptions were highly legible. CONCLUSION： This was a preliminary study, conducted for the first time in homeopathy using newly developed indicators that yield meaningful results. Further studies are necessary in order to evaluate the different factors involved and to plan future interventions to improve the quality of care in healthcare settings.
文摘Objective: The Okinawa prefectural government conducted enhanced surveillance for the Sixth Worldwide Uchinanchu Festival, with participation of more than 5300 visitors from abroad, many of whom were Okinawan or of Okinawan descent, for early detection of Zika virus disease and other potential public health threat outbreaks. Method: Enhanced surveillance conducted from 12 October through 13 November involved four surveillance systems, (Nursery) School Absenteeism Surveillance system ((N)SASSy), Prescription Surveillance (PS), and Official Syndromic Surveillance (OSS), each of them operates routinely, in addition to case-based and sentinel surveillance under the Infectious Diseases Control Law as Official National Surveillance of Infectious Diseases (ONSID). This enhanced surveillance was conducted for analysis and evaluation, with intensive information sharing among concerned parties. Result: We performed the enhanced surveillance for 33 days from 12 October through 13 November. Information from enhanced surveillance was analyzed and evaluated, and eventually summarized as a daily report. There has been one rubella case at an elementary school in Okinawa City on 20 October and a measles case at an elementary school in Uruma City on 2 November. Those two cases were registered into (N)SASSy on a timely basis. The public health center investigated them quickly, and the measles case was denied later because symptoms did not satisfy with case definition. Discussion: We regard enhanced surveillance as useful to confirm events that might demand a public health response. Moreover, the related including public health centers or medical institutions confirmed the situation as valuable for the administrative structure. However, because almost all (nursery) schools or pharmacies are closed during successive holidays, outbreaks that occur on such days cannot be recognized on a timely basis. More sensitive surveillance for such days, with better preparations for ambulance transfer and at emergency departments in hospitals remains as a challenge for future work.
文摘Literature and experimental data relevant to the decision to allow a waiver of in vivo bioequivalence(BE)testing for approval of immediate release(IR)solid dosage forms containing moxifloxacin hydrochloride as the API manufactured by the Government Pharmaceutical Organization(GPO)are evaluated.The solubility of moxifloxacin hydrochloride determined by the shake flask method in six different pH mediums(1.2,4.5,5.4,6.4,6.8 and 7.5)was 4.988±0.1962,27.012±0.4138,21.668±0.5165,47.200±0.8095,73.438±1.7310 and 196.475±4.4624 mg/mL,respectively.The Dose/Solubility(D/S)Ratio of the highest strength(400 mg)available in the market of moxifloxacin tablets was 80.192,14.808,18.460,8.475,5.447 and 2.036 mL,respectively.
文摘Objective:To explore risk factors for the development of pneumothorax in patients with COVID-19 during the second COVID-19 wave at a northern Indian level 2 health facility.Methods:Patients suffering from SARS-CoV-2 infection during the second wave of the COVID-19 pandemic in India(January-June 2021)at a tertiary care teaching hospital and level 2 COVID care facility were included.Cases who suffered from SARS-CoV-2 infection but did not develop pneumothorax were selected as matched controls.All details regarding demographics,clinical presentation,treatment,and outcome were recorded in a semi-structured proforma.Results:Eleven patients with COVID-19 developed pneumothorax during the study period and 40 controls were included in the study.Five cases were smokers in comparison to only two in the control group.Type 2 diabetes mellitus was the most common comorbidity among both groups.Median change in C-reactive protein overall for cases and controls were around+14.0 and-41.9 and was statistically significant.Conclusions:Inflammatory markers like C-reactive protein have significant correlations with the development of pneumothorax in COVID-19-infected patients.There is no sex predisposition to develop pneumothorax among patients with COVID-19.
文摘Objective: This is an audit to evaluate the maternal and perinatal outcome in eclampsia and imminent eclampsia with the management adopted at a tertiary hospital. Methods: During a period of 34 months, from 2003-2007 at Government maternity hospital, Osmania medical college, Hyderabad, 666 women with eclampsia and imminent eclampsia were managed. The number of eclampsia and imminent eclampsia (IE) was 532 and 134, respectively. We have analyzed the clinical profile, parity, age, degree of proteinuria, the period of gestation in weeks, the antenatal care, the number of antenatal visits, referrals from other hospitals, the diastolic B.P. at the time of admission, the recurrence of convulsions and the complications. 1) All the cases of eclampsia and IE were managed with magnesium sulphate as an anticonvulsant. 2) Oral nifedipine, IV labetalol, sublingual nifedipine and nitroglycerine infusion were used to control severe hypertension. 3) Prostaglandin E1 (PGE1) was used for induction of labour (IOL), 25 mcg × 4th hrly, vaginal route and 50 mcg for less than 28 weeks gestation, in 290/424 cases of IOL. Other methods of IOL were employed in 134 cases. Results: Eclampsia (n = 532) occurred antepartum in 407 (75.56%), intrapartum in 76 (14.28%), post partum in 46 (8.64%) and intercurrent in 3 (0.5%) patients. The period of gestation was 34 weeks in 340 patients. Induction of labour with misoprostol was done in 290 with vaginal delivery in 235 (81%) and lower segment caesarean section (LSCS) for failed IOL in 55 (19%) and other methods of IOL were used in 134. The total number of deliveries was 656, with vaginal deliveries in 336 (66.46%) patients, ceasarean deliveries in 220 (33.54%) patients. Ten patients died undelivered. Maternal mortality was 17/666—2.55%. Cerebrovascular events were responsible in 13/17 (76.46%) patients, pulmonary embolisim in 2, aspiration pneumonia in one and sepsis in one. The perinatal mortality was 167/582 (28.69%), PNM when birth weight was >1.5 kg was 59/426 (13.84%), intrauterine fetal deaths at admission were 54 (8.5%), there were four sets of twins. Conclusions: 1) More effective measures to control hypertension and routine administration of anticonvulsant, magnesium sulphate to women with eclampsia should be practised from the first referral unit itself. 2) Our caesarean delivery rate of 33.54% in the very high risk cases of eclampsia and imminent eclampsia is very low compared to others. 3) Induction of labour with misoprostol was successful in 81% with consequent reduction in caesarean section rate and morbidity and mortality associated with caesarean deliveries. Misoprostol has proved to be a safe and effective inducing agent in eclampsia. 4) The maternal mortality in our series is 2.55%.
文摘<b>Introduction:</b> The recent COVID-19 pandemic has prompted concern about the compatibility of IPC guidelines with health care workers, their working practices and behaviours. These guidelines can be difficult and time-consuming to adhere to in practice. By identifying barriers and facilitators to IPC guideline adherence, especially using personal protective equipment (PPE), we can identify focussed strategies that will support health care workers to undertake the IPC measures needed at such a critical time in health care internationally. <b>Material & Methods:</b> This was a cross-sectional study designed during the COVID-19 pandemic management in the South Gujarat region, to analyse the knowledge, attitude and practices of health care workers about their usage of personal protective equipment. A semi-structured questionnaire-based study was prepared, deriving pointers from our previous experience of seasonal flu outbreaks. 225 participants enrolled who were doctors, resident doctors, nurses, lab technicians, ward boys and food distributors. <b>Result:</b> Analysis of the barriers-related questions show good preparedness by the medical institution. Overall we found good knowledge, attitude and practice related to PPE during COVID-19 pandemic management. There are few gaps found in the knowledge of donning of PPE (p-0.0075), N-95 mask related knowledge (p-0.01) and the attitude that PPE use causes discomfort while nursing patients (0.0001).
文摘Objective:An investigation of an outbreak of measles in a district in Nigeria was initiated following confirmation of the outbreak.The objectives of the study were to assess the size and determine the cause of the outbreak. Methods:Visits were made to health facilities and affected communities.Cases were line-listed using specified forms and descriptive epidemiology carried out on collected data.Results:A total of 18 cases and 0 deaths were identified over a period of six weeks.Two of the cases(11%) were 【 9 months of age.The proportion of zero-dose children was 39%.Conclusion:Low herd immunity was suggested as the cause of the outbreak.
文摘Stroke is a devastating and disabling cerebrovascular disease with some amount of residual deficit leading onto economic loss. Recent Indian studies have shown a stroke prevalence rate of 471.58/100,000 population. This study was undertaken to analyse the clinical profile and to arrive at important factors contributing to stroke in 45 years group. This is a descriptive, retrospective cross—sectional study carried out on acute CVA patients, admitted to the I.I.M., RGGGH, Chennai. 150 patients were studied over a period of 3 months in the 2011. 20% of /= 45 years constituted our study population. 18.4% and 22.2% of males and females respectively were young stroke patients. Only 33.3% of patients were brought to the hospital within 6 hours. 90% patients had mild GCS score (>/=13/15) and presented with hemiplegia 76% and 18% had infarct and intracerebral hemorrhage(ICH) respectively. Risk factors: Type A personality (70.7%), Tobacco (60.7%) and Alcohol (44.7%) abuse, Systemic Hypertension (60.7%), Diabetes Mellitus (33.3%), Cardiac disorders (14%). Stroke was seen to be more common in >45 years but still young stroke carries paramount importance due to loss of productive years in these patients. Female predominance was seen in young stroke, with particular reference to puerperal period. Among the comorbid illness systemic hypertension followed by cardiac disorders had important contributing role in young strokes. Most of the patients with infarct and ICH were tobacco and alcohol abusers respectively. A holistic approach encompassing further research in factors involved in young stroke, public awareness, behavioural modification and comorbid medical illness management is the need for the hour.
基金sponsored by National Natural Sciences Foundation Programs (Grant No.71172222) and (Grant No.71572194)the Overseas and Hong Kong and Macao Scholars Collaborative Research Program (Grant No.71428008) of the National Natural Sciences Foundation
文摘Information monopoly of bureaucrats helps them maximize discretionary budget. Public disclosure of budget can alleviate information asymmetry between government and the public and empower public supervision on government budget. With information intermediary function and reputational governance function, the media exert a budget intervention effect in the public disclosure of government budget, which further increases the effect of government budget disclosure. This paper investigates how media reports influence "three public expenses"(TPE) budget planning of central government departments by examining media reports on the disclosure of budget and final accounts and using TPE budget as a proxy variable for discretionary budget of bureaucrats. We have reached the following findings:(1) The higher the TPE budget implementation rate, the greater budget growth will be. But this correlation can be restrained by media attention;(2) Different stance of the media may exert different governance effects on TPE budget. Good news about TPE may motivate bureaucrats to restrain the positive impact of TPE budget implementation on budget growth. However, bad news about TPE will exert its budget intervention effect only when administrative governance mechanism intervenes. This study has broadened research on the media's governance effect from the perspective of government budget transparency and verified that under China's unique institutional background, the media may still play a positive role in public sector governance.
文摘Vaccination is the mainstream measure against coronavirus disease 2019(COVID-19).As of May 2022,more than 80%of the Japanese population has received vaccination doses(1),and booster vaccination programs are in progress.Acute disseminated encephalomyelitis is the most common type of demyelination following vaccinations,and although an increase in neuromyelitis optica spectrum disease(NMOSD)has recently been reported worldwide(2-4),no collective data,especially after newly developed mRNA vaccines against COVID-19,have been reported yet.
基金Supported by National Natural Science Foundation of China(72334006)R&D Program of Beijing Municipal Education Commission(SM202111232002)。
文摘In this paper,an evaluation index system for the coordinated development of regional economy was constructed by considering the aspects of regional development coordination,economic development coordination,economic and social coordination,and resource and environment coordination,which is used to perform comprehensive evaluation of the coordinated development of regional economy.On this basis,the impact of the upgrading of industrial structure,scientific and technological innovation,and government intervention on the coordinated development of regional economy were also investigated.According to the findings of our study,the coordinated development of regional economy in the eastern region was obviously better than that in the central region,while the western region had the lowest coordinated development of regional economy;the upgrading of regional industrial structure promoted the coordinated development of regional economy,while the promoting effect of the scientific and technological innovation on the coordinated development of regional economy were partly achieved by its promotion of the upgrading of industrial structure;the effect of government intervention couldn't be well reflected in the coordination index of regional economy.
文摘传统企业合作伙伴推荐方法过度依赖技术特征而忽视多维因素影响。本研究旨在探究企业合作关系的多维影响因素及推荐机制,为企业寻找合适合作伙伴和制定有效创新策略提供技术支持。本研究提出一种基于交叉多头对比学习网络(cross-attention multi-head contrastive network,CAMC-Net)的企业合作伙伴推荐方法,融合企业、专利和政策数据,通过交叉多头注意力机制建模企业关系的双向互补特性,并引入对比学习策略优化企业表示空间分布。以新能源产业为例,在专利IPC(International Patent Classification)分类号为H02P和H10的企业合作数据集上进行验证,CAMC-Net模型在企业关系识别任务上AUC(area under the curve)分别达到0.9425和0.9251,准确率分别为0.8644和0.8387,F1值分别达到0.8707和0.8471,优于基线模型。通过消融实验证明了政策数据与模型组件的有效性。但现有的研究数据主要基于单一领域,未来需探索跨领域企业合作伙伴推荐方法;同时,模型缺乏对多模态数据的考虑,需要探索更高效的多模态特征融合策略。
文摘This paper researches the overall construction target of government-led urban complex construction projects based on the perspective of sustainable urban development. In order to achieve benefit maximization, the meta-synthesis management for the government-led urban complex construction project is studied. In order to combine theory and practice, several typical government-led urban complex construction project cases, such as Guangzhou Higher Education Mega Center and Guangzhou International Financial City etc. are examined. These examples point to the feasibility of government-led meta-synthesis management and demonstrate the benefits that can be achieved through this model.
