探讨英文学术期刊审稿专家资源管理与维护,提高学术期刊同行评议的效能,加强期刊学术质量把控。文章基于在国际英文学术期刊Global Health Research and Policy的工作实践,根据期刊不同发展阶段的侧重点差异,辅以期刊动态指标数据分析,...探讨英文学术期刊审稿专家资源管理与维护,提高学术期刊同行评议的效能,加强期刊学术质量把控。文章基于在国际英文学术期刊Global Health Research and Policy的工作实践,根据期刊不同发展阶段的侧重点差异,辅以期刊动态指标数据分析,梳理并总结若干条顺应期刊发展规律的审稿专家资源拓展策略,旨在为我国英文学术期刊编辑与审稿专家建立稳定有效的合作互动提供参考。展开更多
本文以Global Health Research and Policy英文期刊近年来国际化建设为例,梳理并总结了中国英文学术期刊在迈向国际化探索和实践中的有效策略。主要包括“借船出海”与国际接轨;整合内部优势资源,对外拓展期刊国际影响力;引进国际人才,...本文以Global Health Research and Policy英文期刊近年来国际化建设为例,梳理并总结了中国英文学术期刊在迈向国际化探索和实践中的有效策略。主要包括“借船出海”与国际接轨;整合内部优势资源,对外拓展期刊国际影响力;引进国际人才,构建学术共同体,加强国际出版传播力;组织特色专题,向世界讲好“中国故事”,创新APC定价规则等。中国英文学术期刊的国际化发展应努力践行中国特色的国际化,建构具有中国特色的出版学科体系和国际学术话语体系。展开更多
A significant number and range of challenges besetting sustainability can be traced to the actions and inter actions of multiple autonomous agents(people mostly)and the entities they create(e.g.,institutions,policies,...A significant number and range of challenges besetting sustainability can be traced to the actions and inter actions of multiple autonomous agents(people mostly)and the entities they create(e.g.,institutions,policies,social network)in the corresponding social-environmental systems(SES).To address these challenges,we need to understand decisions made and actions taken by agents,the outcomes of their actions,including the feedbacks on the corresponding agents and environment.The science of complex adaptive systems-complex adaptive sys tems(CAS)science-has a significant potential to handle such challenges.We address the advantages of CAS science for sustainability by identifying the key elements and challenges in sustainability science,the generic features of CAS,and the key advances and challenges in modeling CAS.Artificial intelligence and data science combined with agent-based modeling promise to improve understanding of agents’behaviors,detect SES struc tures,and formulate SES mechanisms.展开更多
Cardiac injury initiates repair mechanisms and results in cardiac remodeling and fi-brosis,which appears to be a leading cause of cardiovascular diseases.Cardiac fi-brosis is characterized by the accumulation of extra...Cardiac injury initiates repair mechanisms and results in cardiac remodeling and fi-brosis,which appears to be a leading cause of cardiovascular diseases.Cardiac fi-brosis is characterized by the accumulation of extracellular matrix proteins,mainly collagen in the cardiac interstitium.Many experimental studies have demonstrated that fibrotic injury in the heart is reversible;therefore,it is vital to understand differ-ent molecular mechanisms that are involved in the initiation,progression,and resolu-tion of cardiac fibrosis to enable the development of antifibrotic agents.Of the many experimental models,one of the recent models that has gained renewed interest is isoproterenol(ISP)-induced cardiac fibrosis.ISP is a synthetic catecholamine,sympa-thomimetic,and nonselectiveβ-adrenergic receptor agonist.The overstimulated and sustained activation ofβ-adrenergic receptors has been reported to induce biochemi-cal and physiological alterations and ultimately result in cardiac remodeling.ISP has been used for decades to induce acute myocardial infarction.However,the use of low doses and chronic administration of ISP have been shown to induce cardiac fibrosis;this practice has increased in recent years.Intraperitoneal or subcutaneous ISP has been widely used in preclinical studies to induce cardiac remodeling manifested by fibrosis and hypertrophy.The induced oxidative stress with subsequent perturbations in cellular signaling cascades through triggering the release of free radicals is consid-ered the initiating mechanism of myocardial fibrosis.ISP is consistently used to induce fibrosis in laboratory animals and in cardiomyocytes isolated from animals.In recent years,numerous phytochemicals and synthetic molecules have been evaluated in ISP-induced cardiac fibrosis.The present review exclusively provides a comprehensive summary of the pathological biochemical,histological,and molecular mechanisms of ISP in inducing cardiac fibrosis and hypertrophy.It also summarizes the application of this experimental model in the therapeutic evaluation of natural as well as syn-thetic compounds to demonstrate their potential in mitigating myocardial fibrosis and hypertrophy.展开更多
The year 2025 marks the 75th anniversary of the establishment of diplomatic relations between China and Vietnam and the China-Vietnam People-to-People Exchange Year.Over the last 75 years,China has always regarded Vie...The year 2025 marks the 75th anniversary of the establishment of diplomatic relations between China and Vietnam and the China-Vietnam People-to-People Exchange Year.Over the last 75 years,China has always regarded Vietnam as a priority in its neighborhood diplomacy,and Vietnam has regarded its relations with China as the top priority in its independent,all-round,and diversified foreign policy.The two sides have continuously strengthened mutually beneficial cooperation in various fields and elevated their comprehensive strategic partnership to new heights to build a China-Vietnam community with a shared future with strategic significance.展开更多
High-altitude pulmonary hypertension(HAPH)occurs when blood pressure in the pulmonary arteries rises due to exposure to high altitudes above 2,500 m.At these elevations,reduced atmospheric pressure leads to lower oxyg...High-altitude pulmonary hypertension(HAPH)occurs when blood pressure in the pulmonary arteries rises due to exposure to high altitudes above 2,500 m.At these elevations,reduced atmospheric pressure leads to lower oxygen levels,triggering a series of physiological responses,including pulmonary artery constriction,which elevates blood pressure.This review explored the complex pathophysiological mechanisms of HAPH and reviewed current pharmaceutical interventions for its management.Meanwhile,this review particularly emphasized on the emerging research concerning Chinese medicinal plants as potential treatments for HAPH.Traditional Chinese medicines are rich in diverse natural ingredients that show significant promise in alleviating HAPH symptoms.We reviewed both in vitro and in vivo studies to assess the efficacy,safety,and mechanisms of these natural medicines,along with their potential adverse effects.Additionally,this review highlighted new alternative natural remedies,underscoring the need for ongoing research to expand available treatment options for HAPH.展开更多
Objective:To identify the risk factors for acquiring scrub typhus infection among all age group.Methods:A case-control study was carried out from June to December 2019 in collaboration with the Department of Health Se...Objective:To identify the risk factors for acquiring scrub typhus infection among all age group.Methods:A case-control study was carried out from June to December 2019 in collaboration with the Department of Health Services,Kerala.136 Of serologically confirmed scrub typhus reported during 2018 were included and 270 age and sex-matched healthy controls were selected randomly from different locations in the same area where the cases were reported.The risk factors identified were compared between cases and controls,using univariate and multivariable logistic regression analysis to identify the risk factors for scrub typhus infection.Results:Some key factors like house type with individuals residing in houses with concrete roofs are associated with a higher risk of scrub typhus infection compared to tiled roofs(aOR 0.14,95%CI 0.36-0.56,P=0.005).Housewives exhibit a significantly higher risk(aOR 3.97,95%CI 2.15-8.94,P=0.038)of scrub typhus infection.Environmental factors,including the presence of rats(aOR 3.48,95%CI 1.19-6.53,P=0.023),the presence of domestic animals(aOR 2.98,95%CI 1.67-5.19,P<0.001),wet agricultural fields around the house(aOR 3.64,95%CI 1.50-6.54,P<0.001),and hygiene practices like not changing clothes after work(aOR 2.64,95%CI 1.37-4.68,P=0.024),and disposing of the wastes in their own yard(aOR 4.79,95%CI 3.78-9.55,P=0.043)are identified as significant high-risk factors for scrub typhus infection.Conclusions:These findings will be very useful to create awareness among the public and to undertake a detailed control strategy for scrub typhus.展开更多
Earthworms are known to possess magnificent enzymes that hold their importance in a variety of diseases.The ancient traditional medicines in Southeast Asia have also evidenced the beneficial effects of earthworm extra...Earthworms are known to possess magnificent enzymes that hold their importance in a variety of diseases.The ancient traditional medicines in Southeast Asia have also evidenced the beneficial effects of earthworm extract consumption in various ailments.Analgesic,antipyretic,anticoagulant,antiepileptic,antimicrobial,antioxidant,and antiamyloid activities are a few applications along with anticancer and wound healing activities.Earthworm extracts have been consumed in the form of tea,Dilong tea,as well as dried powder,depending on the remedy necessary.In this review,we have discussed the worldwide concept of earthworm extract as medicine and have encompassed the scientific evidence obtained to support the notion about the earthworm extract’s health effect.展开更多
Shales are considered to be sealing units for geological carbon storage and suitable host rocks for nuclear waste repositories due to their low permeability.However,the presence of fractures within these formations ca...Shales are considered to be sealing units for geological carbon storage and suitable host rocks for nuclear waste repositories due to their low permeability.However,the presence of fractures within these formations can significantly alter their flow,transport,and deformation behavior,which is central to the safe implementation of underground storage projects.Fractures not only increase the overall permeability of the rock but also contribute to its anisotropic behavior.This study focuses on characterizing the hydro-mechanical response of a natural fracture to aqueous fluid injection within a shaly specimen of Opalinus Clay.Laboratory experiments were performed to measure the mechanical and flow properties of intact and fractured rock specimens.Subsequently,a three-dimensional(3D)numerical model of water injection into the fractured specimen was developed.This model explicitly accounts for fracture geometry with strain-dependent aperture changes based on the cubic law assumption.Experimental measurements indicate that the fractured shale exhibits permeability up to two orders of magnitude higher than that of the intact counterpart.However,the simulations reveal that fracture permeability locally spans up to eight orders of magnitude.This significant change in permeability affects fluid flow within the rock specimen.The numerical model best reproduces the experimental results for a normal stiffness of the natural fracture of 18.7 MPa/mm at effective mean stresses below 15 MPa,and of 187.2 MPa/mm at higher confinements.This outcome highlights the critical importance of defining the hydro-mechanical parameters of fractures under realistic effective stress conditions with far-reaching implications for secure underground storage.展开更多
文摘探讨英文学术期刊审稿专家资源管理与维护,提高学术期刊同行评议的效能,加强期刊学术质量把控。文章基于在国际英文学术期刊Global Health Research and Policy的工作实践,根据期刊不同发展阶段的侧重点差异,辅以期刊动态指标数据分析,梳理并总结若干条顺应期刊发展规律的审稿专家资源拓展策略,旨在为我国英文学术期刊编辑与审稿专家建立稳定有效的合作互动提供参考。
文摘本文以Global Health Research and Policy英文期刊近年来国际化建设为例,梳理并总结了中国英文学术期刊在迈向国际化探索和实践中的有效策略。主要包括“借船出海”与国际接轨;整合内部优势资源,对外拓展期刊国际影响力;引进国际人才,构建学术共同体,加强国际出版传播力;组织特色专题,向世界讲好“中国故事”,创新APC定价规则等。中国英文学术期刊的国际化发展应努力践行中国特色的国际化,建构具有中国特色的出版学科体系和国际学术话语体系。
基金The National Science Foundation funded this research under the Dy-namics of Coupled Natural and Human Systems program(Grants No.DEB-1212183 and BCS-1826839)support from San Diego State University and Auburn University.
文摘A significant number and range of challenges besetting sustainability can be traced to the actions and inter actions of multiple autonomous agents(people mostly)and the entities they create(e.g.,institutions,policies,social network)in the corresponding social-environmental systems(SES).To address these challenges,we need to understand decisions made and actions taken by agents,the outcomes of their actions,including the feedbacks on the corresponding agents and environment.The science of complex adaptive systems-complex adaptive sys tems(CAS)science-has a significant potential to handle such challenges.We address the advantages of CAS science for sustainability by identifying the key elements and challenges in sustainability science,the generic features of CAS,and the key advances and challenges in modeling CAS.Artificial intelligence and data science combined with agent-based modeling promise to improve understanding of agents’behaviors,detect SES struc tures,and formulate SES mechanisms.
基金United Arab Emirates University,Grant/Award Number:12R104 and 12R121。
文摘Cardiac injury initiates repair mechanisms and results in cardiac remodeling and fi-brosis,which appears to be a leading cause of cardiovascular diseases.Cardiac fi-brosis is characterized by the accumulation of extracellular matrix proteins,mainly collagen in the cardiac interstitium.Many experimental studies have demonstrated that fibrotic injury in the heart is reversible;therefore,it is vital to understand differ-ent molecular mechanisms that are involved in the initiation,progression,and resolu-tion of cardiac fibrosis to enable the development of antifibrotic agents.Of the many experimental models,one of the recent models that has gained renewed interest is isoproterenol(ISP)-induced cardiac fibrosis.ISP is a synthetic catecholamine,sympa-thomimetic,and nonselectiveβ-adrenergic receptor agonist.The overstimulated and sustained activation ofβ-adrenergic receptors has been reported to induce biochemi-cal and physiological alterations and ultimately result in cardiac remodeling.ISP has been used for decades to induce acute myocardial infarction.However,the use of low doses and chronic administration of ISP have been shown to induce cardiac fibrosis;this practice has increased in recent years.Intraperitoneal or subcutaneous ISP has been widely used in preclinical studies to induce cardiac remodeling manifested by fibrosis and hypertrophy.The induced oxidative stress with subsequent perturbations in cellular signaling cascades through triggering the release of free radicals is consid-ered the initiating mechanism of myocardial fibrosis.ISP is consistently used to induce fibrosis in laboratory animals and in cardiomyocytes isolated from animals.In recent years,numerous phytochemicals and synthetic molecules have been evaluated in ISP-induced cardiac fibrosis.The present review exclusively provides a comprehensive summary of the pathological biochemical,histological,and molecular mechanisms of ISP in inducing cardiac fibrosis and hypertrophy.It also summarizes the application of this experimental model in the therapeutic evaluation of natural as well as syn-thetic compounds to demonstrate their potential in mitigating myocardial fibrosis and hypertrophy.
文摘The year 2025 marks the 75th anniversary of the establishment of diplomatic relations between China and Vietnam and the China-Vietnam People-to-People Exchange Year.Over the last 75 years,China has always regarded Vietnam as a priority in its neighborhood diplomacy,and Vietnam has regarded its relations with China as the top priority in its independent,all-round,and diversified foreign policy.The two sides have continuously strengthened mutually beneficial cooperation in various fields and elevated their comprehensive strategic partnership to new heights to build a China-Vietnam community with a shared future with strategic significance.
基金supported by the National Natural Science Foundation of China(Grant Nos.:32270690 and 32070671).
文摘High-altitude pulmonary hypertension(HAPH)occurs when blood pressure in the pulmonary arteries rises due to exposure to high altitudes above 2,500 m.At these elevations,reduced atmospheric pressure leads to lower oxygen levels,triggering a series of physiological responses,including pulmonary artery constriction,which elevates blood pressure.This review explored the complex pathophysiological mechanisms of HAPH and reviewed current pharmaceutical interventions for its management.Meanwhile,this review particularly emphasized on the emerging research concerning Chinese medicinal plants as potential treatments for HAPH.Traditional Chinese medicines are rich in diverse natural ingredients that show significant promise in alleviating HAPH symptoms.We reviewed both in vitro and in vivo studies to assess the efficacy,safety,and mechanisms of these natural medicines,along with their potential adverse effects.Additionally,this review highlighted new alternative natural remedies,underscoring the need for ongoing research to expand available treatment options for HAPH.
文摘Objective:To identify the risk factors for acquiring scrub typhus infection among all age group.Methods:A case-control study was carried out from June to December 2019 in collaboration with the Department of Health Services,Kerala.136 Of serologically confirmed scrub typhus reported during 2018 were included and 270 age and sex-matched healthy controls were selected randomly from different locations in the same area where the cases were reported.The risk factors identified were compared between cases and controls,using univariate and multivariable logistic regression analysis to identify the risk factors for scrub typhus infection.Results:Some key factors like house type with individuals residing in houses with concrete roofs are associated with a higher risk of scrub typhus infection compared to tiled roofs(aOR 0.14,95%CI 0.36-0.56,P=0.005).Housewives exhibit a significantly higher risk(aOR 3.97,95%CI 2.15-8.94,P=0.038)of scrub typhus infection.Environmental factors,including the presence of rats(aOR 3.48,95%CI 1.19-6.53,P=0.023),the presence of domestic animals(aOR 2.98,95%CI 1.67-5.19,P<0.001),wet agricultural fields around the house(aOR 3.64,95%CI 1.50-6.54,P<0.001),and hygiene practices like not changing clothes after work(aOR 2.64,95%CI 1.37-4.68,P=0.024),and disposing of the wastes in their own yard(aOR 4.79,95%CI 3.78-9.55,P=0.043)are identified as significant high-risk factors for scrub typhus infection.Conclusions:These findings will be very useful to create awareness among the public and to undertake a detailed control strategy for scrub typhus.
文摘Earthworms are known to possess magnificent enzymes that hold their importance in a variety of diseases.The ancient traditional medicines in Southeast Asia have also evidenced the beneficial effects of earthworm extract consumption in various ailments.Analgesic,antipyretic,anticoagulant,antiepileptic,antimicrobial,antioxidant,and antiamyloid activities are a few applications along with anticancer and wound healing activities.Earthworm extracts have been consumed in the form of tea,Dilong tea,as well as dried powder,depending on the remedy necessary.In this review,we have discussed the worldwide concept of earthworm extract as medicine and have encompassed the scientific evidence obtained to support the notion about the earthworm extract’s health effect.
基金the funding from the European Research Council(ERC)under the European Union's Horizon 2020 Research and Innovation Program through the Starting Grant GEoREST(www.georest.eu)under Grant agreement No.801809IMEDEA is an accredited“Maria de Maeztu Excellence Unit”(Grant CEX2021-001198+2 种基金funded by MICIU/AEI/10.13039/501100011033)Iman R.Kivi also acknowledges the funding from the Engineering and Physical Sciences Research Council through the UKRI Postdoc Guarantee Award THMC4CCS(Grant No.EP/X026019/1)Hyunbin Kim and Roman Y.Makhnenko are supported by the US National Science Foundation(Grant No.CMMI-2239630).
文摘Shales are considered to be sealing units for geological carbon storage and suitable host rocks for nuclear waste repositories due to their low permeability.However,the presence of fractures within these formations can significantly alter their flow,transport,and deformation behavior,which is central to the safe implementation of underground storage projects.Fractures not only increase the overall permeability of the rock but also contribute to its anisotropic behavior.This study focuses on characterizing the hydro-mechanical response of a natural fracture to aqueous fluid injection within a shaly specimen of Opalinus Clay.Laboratory experiments were performed to measure the mechanical and flow properties of intact and fractured rock specimens.Subsequently,a three-dimensional(3D)numerical model of water injection into the fractured specimen was developed.This model explicitly accounts for fracture geometry with strain-dependent aperture changes based on the cubic law assumption.Experimental measurements indicate that the fractured shale exhibits permeability up to two orders of magnitude higher than that of the intact counterpart.However,the simulations reveal that fracture permeability locally spans up to eight orders of magnitude.This significant change in permeability affects fluid flow within the rock specimen.The numerical model best reproduces the experimental results for a normal stiffness of the natural fracture of 18.7 MPa/mm at effective mean stresses below 15 MPa,and of 187.2 MPa/mm at higher confinements.This outcome highlights the critical importance of defining the hydro-mechanical parameters of fractures under realistic effective stress conditions with far-reaching implications for secure underground storage.
