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组织工程骨和外科人工植入物的仿生技术研究 被引量:8
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作者 雷万军 李秉哲 +4 位作者 曹谊林 Karl Ulrich Kainero 彭淑鸽 崔磊 周宁生 《中国组织工程研究与临床康复》 CAS CSCD 北大核心 2008年第14期2721-2726,共6页
学术背景:虽然已经有应用组织工程骨修复颅颌面骨缺损的报道,但因其缺乏植入早期的力学强度,尚不能应用在四肢负重部位修复骨缺损。目的:探讨负重组织工程骨的新型支架的仿生力学设计、多孔纯镁支架的仿生形态学设计和多孔纯镁支架仿人... 学术背景:虽然已经有应用组织工程骨修复颅颌面骨缺损的报道,但因其缺乏植入早期的力学强度,尚不能应用在四肢负重部位修复骨缺损。目的:探讨负重组织工程骨的新型支架的仿生力学设计、多孔纯镁支架的仿生形态学设计和多孔纯镁支架仿人骨材料表面涂层的仿生技术,以及其他负重组织工程骨候选支架仿生技术和外科人工金属植入物仿生表面涂层技术的发展现状。检索策略:应用计算机检索EI数据库1899/2007与仿生材料相关的文献,并以ELSERVIER、Springer、万方外文文献数据库以及CHKI中文数据库文献索引为辅助,英文检索词"Biomimetic materials",中文检索词"仿生学"。纳入与仿生学、仿生力学、仿生材料及技术相关的文章。文献评价:共得到3501个索引,选择35篇完全符合标准的文献进行综述。其中有关仿生学1篇,生物力学1篇,组织工程用仿生材料1篇,负重组织工程骨的新型支架3篇,医学用金属材料的仿生表面涂层技术12篇,医学用生物陶瓷的仿生表面涂层技术1篇,医学用生物高分子聚合物的仿生涂层技术4篇,纳米生物有机物大分子和生物无机物分子的自组装6篇,生物材料的体积修饰或改性2篇。资料综合:①为解决负重组织工程骨早期力学强度不足问题,仿生涂层的多孔纯镁新型支架是临床试用前期研究最佳候选方案,仿生涂层的多孔纯钛支架,可能作为上述研究的其他选择。②多孔双相生物陶瓷支架压缩强度较低,可能不足以解决问题,利用仿生技术对整体修饰或改性可能是有前景的。③多孔生物高分子聚合物支架,可以利用仿生技术对整体修饰或改性以改善力学性能,但是效果非常有限。结论:到目前为止还不能解决负重组织工程骨的早期力学性能不足问题。外科植入物金属,以及多孔生物金属、生物陶瓷、生物高分子聚合物等组织工程骨支架表面,均可利用仿生涂层技术进行表面修饰或改性。 展开更多
关键词 负重组织工程骨 多孔纯镁支架 仿生涂层 仿生技术 生物材料
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四肢组织工程骨新型支架的比较研究 被引量:3
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作者 李秉哲 雷万军 +4 位作者 曹谊林 Karl Ulrich Kainer 崔磊 周宁生 彭淑鸽 《组织工程与重建外科杂志》 2007年第6期301-304,332,共5页
现代医学的骨组织工程中,种子细胞、生物材料和组织构建是三个最基本要素,而生物材料或支架材料是影响组织构建最为关键的因素之一。它必须具有良好的生物相容性、可降解性、低免疫原性以及一定的空间结构、孔隙率、降解速率等特性。
关键词 支架材料 组织工程骨 四肢 组织构建 生物材料 骨组织工程 生物相容性 现代医学
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Chaboche热粘塑性损伤模型的应用研究 被引量:12
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作者 张克实 Brocks Wolfgang 《航空动力学报》 EI CAS CSCD 北大核心 2002年第5期615-622,共8页
本文讨论了Chaboche粘塑性模型的材料参数确定问题,提出了一种简单实用的模型参数确定方法,并用本文提出的方法确定了TiAl材料的Chaboche模型参数,并用这些参数进行了不同应变率下的拉伸模拟计算、不同应力下的蠕变模拟计算和CT试样在... 本文讨论了Chaboche粘塑性模型的材料参数确定问题,提出了一种简单实用的模型参数确定方法,并用本文提出的方法确定了TiAl材料的Chaboche模型参数,并用这些参数进行了不同应变率下的拉伸模拟计算、不同应力下的蠕变模拟计算和CT试样在阶梯载荷下的蠕变模拟计算。 展开更多
关键词 热粘塑性 蠕变 本构模型 模型参数 材料参数 航空发动机
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Response of upper ocean currents to typhoons at two ADCP moorings west of the Luzon Strait 被引量:7
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作者 陈飞 杜岩 +2 位作者 严厉 王东晓 施平 《Chinese Journal of Oceanology and Limnology》 SCIE CAS CSCD 2010年第5期1002-1011,共10页
We deployed two ADCP mooring systems west of the Luzon Strait in August 2008,and measured the upper ocean currents at high frequency.Two typhoons passed over the moorings during approximately one-month observation per... We deployed two ADCP mooring systems west of the Luzon Strait in August 2008,and measured the upper ocean currents at high frequency.Two typhoons passed over the moorings during approximately one-month observation period.Using ADCP observations,satellite wind and heat flux measurements,and high-resolution model assimilation products,we studied the response of the upper ocean to typhoons.The first typhoon,Nuri,passed over one of the moorings,resulting in strong Ekman divergence and significant surface cooling.The cooling of surface water lagged the typhoon wind forcing about one day and lasted about five days.The second typhoon,Sinlaku,moved northward east of the Luzon Strait,and did not directly impact currents near the observation regions.Sinlaku increased anomalous surface water transport exchange across the Luzon Strait,which modulated the surface layer current of the Kuroshio. 展开更多
关键词 ADCP observation Luzon Strait TYPHOON surface current
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INFLUENCE OF HEAT TREATMENT ON DAMPING BEHAVIOUR OF THE MAGNESIUM WROUGHT ALLOY AZ61 被引量:1
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作者 R. González-Martínez J. Gken +3 位作者 D. Letzig J. Timmerberg K. Steinhoff K.U. Kainer 《Acta Metallurgica Sinica(English Letters)》 SCIE EI CAS CSCD 2007年第4期235-240,共6页
The effect of isochronal heat treatments for 1h on variation of damping, hardness and microstructural change of the magnesium wrought alloy AZ61 was investigated. Damping and hardness behaviour could be attributed to ... The effect of isochronal heat treatments for 1h on variation of damping, hardness and microstructural change of the magnesium wrought alloy AZ61 was investigated. Damping and hardness behaviour could be attributed to the evolution of precipitation process. The influence of precipitation on damping behaviour was explained in the framework of the dislocation string model of Granato and Lücke. 展开更多
关键词 MAGNESIUM AZ61 DAMPING PRECIPITATION
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Interface evolution of TiAl/Ti6242 transient liquid phase joint using Ti, Cu foils as insert metals 被引量:1
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作者 段辉平 K.H.Bohm +1 位作者 V.Ventzke M.Koak 《中国有色金属学会会刊:英文版》 CSCD 2005年第2期375-378,共4页
The interface evolution of TiAl/Ti6242 joint produced by transient liquid phase(TLP) bonding with Ti, Cu foils as insert metals was investigated. The results show that the surface oxide layer on TiAl plays a very impo... The interface evolution of TiAl/Ti6242 joint produced by transient liquid phase(TLP) bonding with Ti, Cu foils as insert metals was investigated. The results show that the surface oxide layer on TiAl plays a very important role in the formation process of the joint. A ‘bridge’ effect is observed because of the presence of the oxide layer on the surface of TiAl. The diffusion behavior of Cu atoms in TiAl is strongly controlled by the vacancies beneath the surface of TiAl. Based on the interface diffusion and interface wettability, a mechanism for the effect of bonding pressure, bonding temperature, holding time and stacking sequence of the insert foils on the joint formation process were proposed. 展开更多
关键词 铝钛合金 瞬态液相压焊 表面蒸气 机械性能
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Effects of methyl-,phenyl-,ethylmercury and mercurychlorid on immune cells of harbor seals(Phoca vitulina)
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作者 Antje Kakuschke Elizabeth Valentine-Thon +2 位作者 Sonja Fonfara Katharina Kramer Andreas Prange 《Journal of Environmental Sciences》 SCIE EI CAS CSCD 2009年第12期1716-1721,共6页
Mercury (Hg) is present in the marine environment as a natural metal often enhanced through human activities. Depending on its chemical form, Hg can cause a wide range of immunotoxic effects. In this study, the infl... Mercury (Hg) is present in the marine environment as a natural metal often enhanced through human activities. Depending on its chemical form, Hg can cause a wide range of immunotoxic effects. In this study, the influence of methyl-, ethyl- and phenylmercury as well as mercurychloride on immune functions was evaluated. Two parameters of cellular immunity, proliferation and mRNA cytokine expression of interleukin-2, -4, and transforming growth factor β, were investigated in harbor seal lymphocytes after in vitro exposure to Hg compounds. While all Hg compounds had a suppressive effect on proliferation, differences between juvenile and adult seals were found. Lymphocytes from juveniles showed a higher susceptibility to the toxic effect compared to lymphocytes from adults. Furthermore, the degree of inhibition of proliferation varied among the four Hg compounds. The organic compounds seem to be more immunotoxic than the inorganic compound. Finally, for the cytokine expression of methylmercury-incubated lymphocytes, timedependent changes were observed, but no dose-dependency was found. Marine mammals of the North Sea are burdened with Hg, and lymphocytes of harbor seals may be functionally impaired by this metal. The present in vitro study provides baseline information for future studies on the immunotoxic effects of Hg on cellular immunity of harbor seals. 展开更多
关键词 harbor seal MERCURY lymphocyte proliferation cytokine expression North Sea
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Effect of the formation process of transient liquid phase (TLP) on the interface structure of TiAl joints
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作者 Huiping Duan Jun Luo +1 位作者 Karl-Heinz Bohm Mustafa Kogak 《Journal of University of Science and Technology Beijing》 CSCD 2005年第5期431-435,共5页
TiAl has been joined employing the transient liquid phase (TLP) bonding with Ti combined with Cu, Ni or Fe foils. Experimental results showed that though the interface structures of the joints are quite different, a... TiAl has been joined employing the transient liquid phase (TLP) bonding with Ti combined with Cu, Ni or Fe foils. Experimental results showed that though the interface structures of the joints are quite different, all the joined zones are composed of five sublayers, i.e. two diffusion zones, two interfacial zones and an interlayer. It has been convinced that the formation process of the transient liquid phase controls the diffusion behavior of melting point depressant (MPD) Cu, Ni, and Fe atoms, which leads to form different interface structures of the joints. 展开更多
关键词 TIAL transient liquid phase (TLP) BONDING INTERFACE
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Structural Integrity of Welded Structures:Process-Property-Performance (3P) Relationship
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作者 Mustafa Koak 《机械制造文摘(焊接分册)》 2011年第1期37-37,共1页
In most engineering metallic structures,welded joints are often the locations for the crack initiation due to inherent metallurgical,geometrical defects as well as heterogeneity in mechanical properties and presence o... In most engineering metallic structures,welded joints are often the locations for the crack initiation due to inherent metallurgical,geometrical defects as well as heterogeneity in mechanical properties and presence of residual stresses. In order to maintain structural integrity of welded structures for whole service life of the structure,relationship between welding process,properties(of base metal & weld joint) and performance of the structure(requirements & controlling factors of the service conditions) should be well-understood and established. The quality of the relationship between this 3P is crucial to obtain economic and safe design,fabrication and service life. Specific features of each welding and joining process should ideally be well understood by the designer for a selected material at the early stage of the design. Resulting micro-structural & mechanical and geometrical properties should be obtained to have defined or intended structural performance under either specific environment or stresses. Nowadays,use of advanced welding processes with high performance steels and aluminum alloys together with well established and high quality welding consumables ensures safe and economic design,fabrication,inspection and service of the welded components and structures. Additionally,new developments in the fitness-for-service(FFS) procedures(e. g. BS 7910,R6 and FITNET FFS) and codes have significantly increased the accuracy of the structural integrity assessment of weld flaws. More and more engineering structures are built using multi-material design approach where numbers of materials with significantly different mechanical properties are joined to create weight and cost-efficient structures. Structural safety evaluation of such material-mix structures require sound understanding and description of the welding process,interfacial & weld joint properties in conjunction with global behavior of the component under external loadings. The existing knowledge on the weld strength mismatch will significantly help to design innovative products and resolve complex deformation and fracture problems of such emerging structures. Such structures are expected to perform under severe service conditions with minimum maintenance and safely. This Houdremont Lecture will,therefore,address to the engineering significance of the relationship between different stages of the"life of the welded structure"which I have been describing as 3P(Process-Property-Performance) of welded structures. 展开更多
关键词 焊接 机械制造 技术信息 工艺
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千年气候模拟与中国东部温度重建序列的比较研究 被引量:34
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作者 刘健 Hans von Storch +3 位作者 陈星 Eduardo Zorita 郑景云 王苏民 《科学通报》 EI CAS CSCD 北大核心 2005年第20期2251-2255,共5页
利用全球海气耦合气候模式ECHO-G进行的1000年长时间积分气候模拟试验与中国东部区域温度重建资料作对比, 以验证ECHO-G模拟中国区域气候的能力, 并探讨近千年来中国区域气候变化的原因. 重建资料是中国东部地区(25°~40°N, 1... 利用全球海气耦合气候模式ECHO-G进行的1000年长时间积分气候模拟试验与中国东部区域温度重建资料作对比, 以验证ECHO-G模拟中国区域气候的能力, 并探讨近千年来中国区域气候变化的原因. 重建资料是中国东部地区(25°~40°N, 105°E 以东)1000年来分辨率为30年的冬半年温度距平变化序列. 模拟试验以随时间变化的有效太阳辐射、CO2浓度和CH4浓度场为外强迫, 从1000年开始积分至1990年. 结果表明: 重建和模拟结果的相关系数为0.37, 置信度为97.5%. 模拟和重建结果均反映出了1000~1300年的中世纪暖期、1300~1850年的小冰期和1900年之后的升温期. 对于1300~1850年的小冰期和1900年之后的升温期, 模拟和重建的正负距平基本一致, 尤其是1670~1710年Maunder太阳黑子最小期时, 模拟和重建值都达到了温度低谷, 且无位相差异. 但对1000~1300年的中世纪暖期, 模拟与重建资料存在显著差异, 这与重建资料质量降低有关. 模拟的变幅(1.62 K)略小于重建值(2.0 K),但两者具有较好的可比性. 模拟结果的诊断分析表明, 在1000年尺度上, 太阳辐射和火山活动是控制全球和区域温度变化的主要因子, 而在最近百年尺度上, 温室气体含量的变化对快速增温起着更为重要的作用. 展开更多
关键词 气候模拟 中国东部 温度重建序列 温室气体 置信度 相关系数
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Simulated and reconstructed winter temperature in the eastern China during the last millennium 被引量:22
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作者 LIU Jian H. Storch +3 位作者 CHEN Xing E. Zorita ZHENG Jingyun WANG Sumin 《Chinese Science Bulletin》 SCIE EI CAS 2005年第24期2872-2877,共6页
The reconstructed temperature anomalies in the eastern China were compared with the output from a 1000-year model simulation in an attempt to evaluate the model’s regional simulation skills and to understand the caus... The reconstructed temperature anomalies in the eastern China were compared with the output from a 1000-year model simulation in an attempt to evaluate the model’s regional simulation skills and to understand the causes of climate change in China over the last millennium. The reconstructed data are the winter half-year temperature anomalies in the central region of eastern China (25°-40°N, east of 105°E) for the last 1000 years with a 30-year resolu- tion. The model used is the global atmosphere-ocean coupled climate model, ECHO-G, which was driven by time-varying external forcings including solar radiation, volcanic erup- tions, and greenhouse gas concentrations (CO2 and CH4) for the same period. The correlation coefficient between the simulated and reconstructed time series is 0.37, which is sta- tistically significant at a confidence level of 97.5%. The Me- dieval Warm Period (MWP) during 1000-1300 A.D., the Little Ice Age (LIA) during 1300-1850 A.D. and the modern warming period after 1900 A.D. are all recognizable from both the simulated and reconstructed temperatures. The anomalies associated with the LIA and the modern warming simulated by the model are in good consistency with the re- constructed counterpart. In particular during the Maunder sun-spot minimum (1670-1710 A.D.), both the simulated and reconstructed temperature anomalies reach their min- ima without any phase difference. But in the earlier MWP, significant discrepancies exist between the simulation and the reconstruction, which might reflect the degrading quality of the reconstruction data. The range of the simulated anoma- lies (1.62 K) is comparable with that of reconstructed (2.0 K). Diagnosis of the model results indicates that, during the last millennium, variations in solar radiation and volcanic activ- ity are the main controlling factors on regional temperature change, while in the recent 100 years, the change of the con- centration of greenhouse gases plays most important role in explaining the rapid temperature rising. 展开更多
关键词 古气候 中国东部 冬季 气温 温度模拟 温度重构
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