While the use of three-dimensional (3D) geographical information system (GIS) is becoming in rapid development and being used in various fields such as urban and regional planning, disaster management and planning, mo...While the use of three-dimensional (3D) geographical information system (GIS) is becoming in rapid development and being used in various fields such as urban and regional planning, disaster management and planning, mobile navigation and etc., commercial and open source GIS software packages tend to offer 3D-GIS functionalities for their products. On the basis, GIS analysis functions are to provide information with respect to geographical location and by having 3D spatial data as an input, it will give advantages in providing horizontal position information. However, to analyze moving objects (temporal) in 3D seems not an easy task and not fully supported by current GIS platform packages. Previously in two-dimensional (2D) GIS practice, main issue addressed by researchers in managing temporal spatial objects is GIS packages were designed based on hardware and software constraints whereby it should be based on the temporal spatial objects ontology. Nowadays, the trend of managing temporal 3D data is via 3D spatial simulation or animation. This approach will not in assistance for GIS users in conducting spatial queries. Without having a suitable ontology and valid topological data structure for temporal 3D data, it will cause repetitive of temporal data (redundancy) and complications in executing spatial analysis in 3D environment. Therefore this paper focuses on the ontology for managing moving 3D spatial objects (i.e. air pollution, flood). The characteristics of moving objects were reviewed thoroughly by categorizing it based on its different appearances. Moreover, existing methods in managing temporal database were addressed and discussed for its practicalities. Another important aspect in managing temporal 3D objects is the implementation of topological data structures for 3D spatial objects were reviewed. In the last section of this paper it summarized the issues and further ideas towards implementing and managing temporal 3D spatial objects in GIS based on the Geoinformation Ontology (GeO).展开更多
AIM: To investigate the relationship between primary afferent neurons, endothelin (ET) and the role of its receptors on ethanol-induced gastric damage in cirrhotic rats. METHODS: Cirrhosis and portal hypertension were...AIM: To investigate the relationship between primary afferent neurons, endothelin (ET) and the role of its receptors on ethanol-induced gastric damage in cirrhotic rats. METHODS: Cirrhosis and portal hypertension were induced in rats by bile duct ligation (BDL) while controls had a sham operation. The association between ET and afferent neurons on the gastric mucosa was evaluated by capsaicin treatment in newborn rats, the use of ET agonists or antagonists, gastric ET-1 and -3 mRNA and synthetic capacity. Ethanol-induced damage was assessed using ex vivo gastric chamber experiments.Gastric blood flow was measured by laser-Doppler flow-metry. RESULTS: ET-3 and an ETB receptor antagonist sig- nificantly reduced the extent of ethanol-induced gastric damage in BDL rats. Gastric ET-1 and -3 levels were 30% higher in BDL rats compared to control rats. Cap-saicin treatment restored the gastric resistance and blood flow responses to topical application of ethanol in BDL rats and ET-1 and -3 production to levels observed in controls. CONCLUSION: Our results suggest that the reduced resistance of the gastric mucosa of cirrhotic rats to ethanol-induced injury is a phenomenon modulated by ET through the ET B receptor and by sensory afferent neurons.展开更多
文摘While the use of three-dimensional (3D) geographical information system (GIS) is becoming in rapid development and being used in various fields such as urban and regional planning, disaster management and planning, mobile navigation and etc., commercial and open source GIS software packages tend to offer 3D-GIS functionalities for their products. On the basis, GIS analysis functions are to provide information with respect to geographical location and by having 3D spatial data as an input, it will give advantages in providing horizontal position information. However, to analyze moving objects (temporal) in 3D seems not an easy task and not fully supported by current GIS platform packages. Previously in two-dimensional (2D) GIS practice, main issue addressed by researchers in managing temporal spatial objects is GIS packages were designed based on hardware and software constraints whereby it should be based on the temporal spatial objects ontology. Nowadays, the trend of managing temporal 3D data is via 3D spatial simulation or animation. This approach will not in assistance for GIS users in conducting spatial queries. Without having a suitable ontology and valid topological data structure for temporal 3D data, it will cause repetitive of temporal data (redundancy) and complications in executing spatial analysis in 3D environment. Therefore this paper focuses on the ontology for managing moving 3D spatial objects (i.e. air pollution, flood). The characteristics of moving objects were reviewed thoroughly by categorizing it based on its different appearances. Moreover, existing methods in managing temporal database were addressed and discussed for its practicalities. Another important aspect in managing temporal 3D objects is the implementation of topological data structures for 3D spatial objects were reviewed. In the last section of this paper it summarized the issues and further ideas towards implementing and managing temporal 3D spatial objects in GIS based on the Geoinformation Ontology (GeO).
基金Supported by A fellowship from Fundaao de Amparo a Pes-quisa do Estado de Sao Paulo, FAPESP, Brazil (to Cmara PRS)a research grant from FAPESP (to Ferraz JGP)
文摘AIM: To investigate the relationship between primary afferent neurons, endothelin (ET) and the role of its receptors on ethanol-induced gastric damage in cirrhotic rats. METHODS: Cirrhosis and portal hypertension were induced in rats by bile duct ligation (BDL) while controls had a sham operation. The association between ET and afferent neurons on the gastric mucosa was evaluated by capsaicin treatment in newborn rats, the use of ET agonists or antagonists, gastric ET-1 and -3 mRNA and synthetic capacity. Ethanol-induced damage was assessed using ex vivo gastric chamber experiments.Gastric blood flow was measured by laser-Doppler flow-metry. RESULTS: ET-3 and an ETB receptor antagonist sig- nificantly reduced the extent of ethanol-induced gastric damage in BDL rats. Gastric ET-1 and -3 levels were 30% higher in BDL rats compared to control rats. Cap-saicin treatment restored the gastric resistance and blood flow responses to topical application of ethanol in BDL rats and ET-1 and -3 production to levels observed in controls. CONCLUSION: Our results suggest that the reduced resistance of the gastric mucosa of cirrhotic rats to ethanol-induced injury is a phenomenon modulated by ET through the ET B receptor and by sensory afferent neurons.
