For environmental applications,it is crucial to rationally design and synthesize photocatalysts with positive exciton splitting and interfacial charge transfer.Here,a novel Agbridged dual Z-scheme Ag/g-C_(3)N_(4)/CoNi...For environmental applications,it is crucial to rationally design and synthesize photocatalysts with positive exciton splitting and interfacial charge transfer.Here,a novel Agbridged dual Z-scheme Ag/g-C_(3)N_(4)/CoNi-LDH plasmonic heterojunction was successfully synthesized using a simple method,with the goal of overcoming the common drawbacks of traditional photocatalysts such as weak photoresponsivity,rapid combination of photogenerated carriers,and unstable structure.These materials were characterized by XRD,FT-IR,SEM,TEM UV-Vis/DRS,and XPS to verify the structure and stability of the heterostructure.The pristine LDH,g-C_(3)N_(4),and Ag/g-C_(3)N_(4)/CoNi-LDH composite were investigated as photocatalysts for water remediation,an environmentally motivated process.Specifically,the photocatalytic degradation of tetracycline was studied as a model reaction.The performance of the supports and composite catalyst were determined by evaluating both the degradation and adsorption phenomenon.The influence of several experimental parameters such as catalyst loading,pH,and tetracycline concentrationwere evaluated.The current study provides important data for water treatment and similar environmental protection applications.展开更多
<strong>Introduction:</strong> Chronic renal failure (CRF) is defined as glomerular filtration rate (GFR) less than 60 ml/min/1.73m<sup>2</sup> for at least three (3) months. Anemia is one of i...<strong>Introduction:</strong> Chronic renal failure (CRF) is defined as glomerular filtration rate (GFR) less than 60 ml/min/1.73m<sup>2</sup> for at least three (3) months. Anemia is one of its most common complications. Anemia increases the risk factor for cardiovascular mortality by 18% per gram of hemoglobin loss. <strong>Objectives:</strong> To determine the prevalence and characteristics of this severe anemia, to determine the indications for transfusion, the complications related to this anemia, the evolution and the prognosis of these patients. <strong>Materials and Methods:</strong> This was a descriptive study with retrospective data collection over 18 months (January 1, 2017 to June 30, 2018) that included hospitalized CRF patients. Were included, non-dialyzed chronic renal failure patients with Hb ≤ 5 g/dl hospitalized during the said period. Not included were chronic renal failure patients with an Hb level ≥ 5 g/dl, those followed up and/or hospitalized outside the study period. <strong>Results:</strong> Among 1176 patients, 26 had severe anemia (Hb level ≤ 5 g/dl) on CRF, a prevalence of 2.21%. The mean age was 40 years ± 32.62 with extremes of 15 and 67 years. Seventeen women and 9 men. The etiology of chronic renal failure (CRF) was hypertensive vascular nephropathy in 50% of cases. CRF was end-stage in 18 patients (69.2%). The mean hemoglobin level was 4.10 g/dl ± 0.64 with extremes of 2 and 5 g/dl. The anemia was microcytic hypochromic in 50% and aregenerative (96.2%). The main symptoms were asthenia in 20 cases (76.9%), dizziness in 20 cases (76.9%), exertional dyspnea in 19 cases (73.1%). Signs of cardiac decompensation (n = 12) were jugular turgor 10 cases (38.5%), hepato-jugular reflux 06 cases (23.1%), mitral insufficiency murmur 06 cases (23.1%). The main complication was left ventricular hypertrophy 17 cases (77.3%). There was no correlation between anemia and sex (p = 0.291), age (p = 0.778), malaria (p = 0.158), etiology of CRF (p = 0.26). The evolution after treatment of anemia was favorable in 19 patients (73.1%), unfavorable in 02 patients (7.7%) and 05 deaths (19.2%). The deaths were of cardiovascular cause: left ventricular insufficiency 04 cases, stroke 01 case. <strong>Conclusion:</strong> Anemia is frequent in patients with chronic renal failure and remains an important risk factor for cardiovascular disease and poor general condition.展开更多
With every passing day,the demand for data traffic is increasing,and this urges the research community not only to look for an alternating spectrum for communication but also urges radio frequency planners to use the ...With every passing day,the demand for data traffic is increasing,and this urges the research community not only to look for an alternating spectrum for communication but also urges radio frequency planners to use the existing spectrum efficiently.Cell sizes are shrinking with every upcoming communication generation,which makes base station placement planning even more complex and cumbersome.In order to make the next-generation cost-effective,it is important to design a network in such a way that it utilizes the minimum number of base stations while ensuring seamless coverage and quality of service.This paper aims at the development of a new simulation-based optimization approach using a hybrid metaheuristic and metamodel applied in a novel mathematical formulation of the multi-transmitter placement planning(MTPP)problem.We first develop a new mathematical programming model for MTPP that is flexible to design the locations for any number of transmitters.To solve this constrained optimization problem,we propose a hybrid approach using the radial basis function(RBF)metamodel to assist the particle swarm optimizer(PSO)by mitigating the associated computational burden of the optimization procedure.We evaluate the effectiveness and applicability of the proposed algorithm by simulating the MTPP model with two,three,four and five transmitters and estimating the Pareto front for optimal locations of transmitters.The quantitative results show that almost maximum signal coverage can be obtained with four transmitters;thus,it is not a wise idea to use higher number of transmitters in the model.Furthermore,the limitations and future works are discussed.展开更多
Electrochemical water splitting represents a sustainable technology for hydrogen(H_(2))production.However,its large-scale implementation is hindered by the high overpotentials required for both the cathodic hydrogen e...Electrochemical water splitting represents a sustainable technology for hydrogen(H_(2))production.However,its large-scale implementation is hindered by the high overpotentials required for both the cathodic hydrogen evolution reaction(HER)and the anodic oxygen evolution reaction(OER).Transition metal-based catalysts have garnered significant research interest as promising alternatives to noble-metal catalysts,owing to their low cost,tunable composition,and noble-metal-like catalytic activity.Nevertheless,systematic reviews on their application as bifunctional catalysts for overall water splitting(OWS)are still limited.This review comprehensively outlines the principal categories of bifunctional transition metal electrocatalysts derived from electrospun nanofibers(NFs),including metals,oxides,phosphides,sulfides,and carbides.Key strategies for enhancing their catalytic performance are systematically summarized,such as heterointerface engineering,heteroatom doping,metal-nonmetal-metal bridging architectures,and single-atom site design.Finally,current challenges and future research directions are discussed,aiming to provide insightful perspectives for the rational design of high-performance electrocatalysts for OWS.展开更多
Stroke is the leading cause of mortality globally,ultimately leading to severe,lifelong neurological impairments.Patients often suffer from a secondary cascade of damage,including neuroinflammation,cytotoxicity,oxidat...Stroke is the leading cause of mortality globally,ultimately leading to severe,lifelong neurological impairments.Patients often suffer from a secondary cascade of damage,including neuroinflammation,cytotoxicity,oxidative stress,and mitochondrial dysfunction.Regrettably,there is a paucity of clinically available therapeutics to address these issues.Emerging evidence underscores the pivotal roles of astrocytes,the most abundant glial cells in the brain,throughout the various stages of ischemic stroke.In this comprehensive review,we initially provide an overview of the fundamental physiological functions of astrocytes in the brain,emphasizing their critical role in modulating neuronal homeostasis,synaptic activity,and blood-brain barrier integrity.We then delve into the growing body of evidence that highlights the functional diversity and heterogeneity of astrocytes in the context of ischemic stroke.Their well-established contributions to energy provision,metabolic regulation,and neurotransmitter homeostasis,as well as their emerging roles in mitochondrial recovery,neuroinflammation regulation,and oxidative stress modulation following ischemic injury,are discussed in detail.We also explore the cellular and molecular mechanisms underpinning these functions,with particular emphasis on recently identified targets within astrocytes that offer promising prospects for therapeutic intervention.In the final section of this review,we offer a detailed overview of the current therapeutic strategies targeting astrocytes in the treatment of ischemic stroke.These astrocyte-targeting strategies are categorized into traditional small-molecule drugs,microRNAs(miRNAs),stem cell-based therapies,cellular reprogramming,hydrogels,and extracellular vesicles.By summarizing the current understanding of astrocyte functions and therapeutic targeting approaches,we aim to highlight the critical roles of astrocytes during and after stroke,particularly in the pathophysiological development in ischemic stroke.We also emphasize promising avenues for novel,astrocyte-targeted therapeutics that could become clinically available options,ultimately improving outcomes for patients with stroke.展开更多
In this study,we developed a novel bilayered scaffold consisting of a bottom layer composed of the Decellularized Bovine Pericardium(DP)coated with Polyaniline Nanoparticles(PANINPs)and a top layer made of an electros...In this study,we developed a novel bilayered scaffold consisting of a bottom layer composed of the Decellularized Bovine Pericardium(DP)coated with Polyaniline Nanoparticles(PANINPs)and a top layer made of an electrospun Poly(lactic-co-glycolic acid)/Gelatin(PLGA/Gel)membrane incorporated with Vascular Endothelial Growth Fac-tor(VEGF)and hawthorn extract.Functionally,the DP supplies native Extracellular Matrix(ECM)components and mechanical support,while PANINPs provide conductivity.The electrospun PLGA/Gel layer mimics fibrous ECM.It incorporates bioactives,with VEGF promoting pro-angiogenic stimulation and hawthorn extract enhanc-ing anticoagulant activity,as well as increasing surface hydrophilicity.The tissue adhesive ensures the interfacial integrity between the two layers.Decellularization efficiency was confirmed histologically using 4',6-diamidino-2-phenylindole(DAPI)and Hematoxylin-Eosin(H&E)staining.The DP exhibited a DNA content of 115.9±47.8 ng/mg DNA,compared to 982.88±395.42 ng/mg in Native Pericardium(NP).The PANINPs had an average par-ticle size of 104.94±13.7 nm.The conductivity of PANINPs-coated decellularized pericardium was measured to be 9.093±8.6×10-4 S/cm using the four-point probe method.PLGA/Gel membranes containing hawthorn extract(1%,5%,10%,and 15%w/v)and VEGF(0.1μg/mL,0.5μg/mL,and 1μg/mL)were fabricated by electrospinning,result-ing in fiber diameters between 850 and 1200 nm and pore sizes between 14 and 20μm.The anticoagulant efficiency of the membranes containing hawthorn extract reached 430 s in the Activated Partial Thromboplastin Time Assay(aPTT).Mechanical testing revealed a tensile strength of 22.70±6.33 MPa,an elongation of 53.58±10.63%,and Young's modulus of 0.67±0.10 MPa.The scaffold also exhibited over 91%cell viability and excellent cardiomyo-cyte adhesion.The hemolysis ratio was determined to be 0.421±0.191%,which confirms its blood compatibility.Our results indicate that the proposed bilayered scaffold can be a promising candidate for cardiac patch applications.展开更多
With the proliferation of Internet of Things(IoT)devices,securing these interconnected systems against cyberattacks has become a critical challenge.Traditional security paradigms often fail to cope with the scale and ...With the proliferation of Internet of Things(IoT)devices,securing these interconnected systems against cyberattacks has become a critical challenge.Traditional security paradigms often fail to cope with the scale and diversity of IoT network traffic.This paper presents a comparative benchmark of classic machine learning(ML)and state-of-the-art deep learning(DL)algorithms for IoT intrusion detection.Our methodology employs a twophased approach:a preliminary pilot study using a custom-generated dataset to establish baselines,followed by a comprehensive evaluation on the large-scale CICIoTDataset2023.We benchmarked algorithms including Random Forest,XGBoost,CNN,and StackedLSTM.The results indicate that while top-performingmodels frombothcategories achieve over 99%classification accuracy,this metric masks a crucial performance trade-off.We demonstrate that treebased ML ensembles exhibit superior precision(91%)in identifying benign traffic,making them effective at reducing false positives.Conversely,DL models demonstrate superior recall(96%),making them better suited for minimizing the interruption of legitimate traffic.We conclude that the selection of an optimal model is not merely a matter of maximizing accuracy but is a strategic choice dependent on the specific security priority either minimizing false alarms or ensuring service availability.Thiswork provides a practical framework for deploying context-aware security solutions in diverse IoT environments.展开更多
To ensure the efficient use of resources,particularly in water-scarce arid and semi-arid regions where abiotic stress threatens food security,assessing soil and climate suitability for specific crops is crucial.Simult...To ensure the efficient use of resources,particularly in water-scarce arid and semi-arid regions where abiotic stress threatens food security,assessing soil and climate suitability for specific crops is crucial.Simultaneously,food production must align with sustainable development goals by minimizing negative environmental impacts.Therefore,establishing agro-climatic suitability using a spatiotemporal approach is essential.This involves three key steps:first,determining the climatically appropriate months based on the species’requirements(temporal suitability),and second,establishing the soil suitability of specific plots(spatial suitability).Following this,quantifying crop evapotranspiration allows for optimized water use.This study used climatic and soil variables from diverse data sources to characterize the study area.Subsequently,suitability classes for Portulaca oleracea were determined based on existing literature.Our analysis concerning temporal suitability revealed that June and July are the optimal months for sowing this species in all of the municipalities.Spatially,approximately 30%of the agricultural land use of the study area exhibits a highly suitable class in most municipalities.Both dimensions,the temporal and the spatially,were validated through Chi square(χ^(2))Goodness-of-Fit test and theχ^(2)test of independence,respectively.Consequently,for a one-month production cycle during periods of high suitability,estimated evapotranspiration values are between 210 and 245 mm.In brief,the study area demonstrates favorable agro-climatic conditions for P.oleracea cultivation in specific months of the year according to parameters used,with potential in a large proportion of agricultural land and achievable water requirements.展开更多
The flow of a tetra-hybrid Casson nanofluid(Al_(2)O_(3)-CuO-TiO_(2)-Ag/H_(2)O)over a nonlinear stretching sheet is investigated.The Buongiorno model is used to account for thermophoresis and Brownian motion,while ther...The flow of a tetra-hybrid Casson nanofluid(Al_(2)O_(3)-CuO-TiO_(2)-Ag/H_(2)O)over a nonlinear stretching sheet is investigated.The Buongiorno model is used to account for thermophoresis and Brownian motion,while thermal radiation is incorporated to examine its influence on the thermal boundary layer.The governing partial differential equations(PDEs)are reduced to a system of nonlinear ordinary differential equations(ODEs)with fully non-dimensional similarity transformations involving all independent variables.To solve the obtained highly nonlinear system of differential equations,a novel Clique polynomial collocation method is applied.The analysis focuses on the effects of the Casson parameter,power index,radiation parameter,thermophoresis parameter,Brownian motion parameter,and Lewis number.The key findings show that thermal radiation intensifies the thermal boundary layer,the Casson parameter reduces the velocity,and the Lewis number suppresses the concentration with direct relevance to polymer processing,coating flows,electronic cooling,and biomedical applications.展开更多
Rapid evolutions of the Internet of Electric Vehicles(IoEVs)are reshaping and modernizing transport systems,yet challenges remain in energy efficiency,better battery aging,and grid stability.Typical charging methods a...Rapid evolutions of the Internet of Electric Vehicles(IoEVs)are reshaping and modernizing transport systems,yet challenges remain in energy efficiency,better battery aging,and grid stability.Typical charging methods allow for EVs to be charged without thought being given to the condition of the battery or the grid demand,thus increasing energy costs and battery aging.This study proposes a smart charging station with an AI-powered Battery Management System(BMS),developed and simulated in MATLAB/Simulink,to increase optimality in energy flow,battery health,and impractical scheduling within the IoEV environment.The system operates through real-time communication,load scheduling based on priorities,and adaptive charging based on batterymathematically computed State of Charge(SOC),State of Health(SOH),and thermal state,with bidirectional power flow(V2G),thus allowing EVs’participation towards grid stabilization.Simulation results revealed that the proposed model can reduce peak grid load by 37.8%;charging efficiency is enhanced by 92.6%;battery temperature lessened by 4.4℃;SOH extended over 100 cycles by 6.5%,if compared against the conventional technique.By this way,charging time was decreased by 12.4% and energy costs dropped by more than 20%.These results showed that smart charging with intelligent BMS can boost greatly the operational efficiency and sustainability of the IoEV ecosystem.展开更多
Titanium exhibits outstanding properties,particularly,high specific strength and resistance to both high and low temperatures,earning it a reputation as the metal of the future.However,because of the highly reactive n...Titanium exhibits outstanding properties,particularly,high specific strength and resistance to both high and low temperatures,earning it a reputation as the metal of the future.However,because of the highly reactive nature of titanium,metallic titanium production involves extensive procedures and high costs.Considering its advantages and limitations,the European Union has classified titanium metal as a critical raw material(CRM)of low category.The Kroll process is predominantly used to produce titanium;however,molten salt electrolysis(MSE)is currently being explored for producing metallic titanium at a low cost.Since 2000,electrolytic titanium production has undergone a wave of technological advancements.However,because of the intermediate and disproportionation reactions in the electrolytic titanium production process,the process efficiency and titanium purity according to industrial standards could not be achieved.Consequently,metallic titanium production has gradually diversified into employing technologies such as thermal reduction,MSE,and titanium alloy preparation.This study provides a comprehensive review of research advances in titanium metal preparation technologies over the past two decades,highlighting the challenges faced by the existing methods and proposing potential solutions.It offers useful insights into the development of low-cost titanium preparation technologies.展开更多
Mexican oregano(Lippia graveolens Kunth)is an aromatic species of high culinary and medicinal relevance.In Mexico,more than 40 taxa with characteristic aroma and flavor are commercially recognized as oregano,with L.gr...Mexican oregano(Lippia graveolens Kunth)is an aromatic species of high culinary and medicinal relevance.In Mexico,more than 40 taxa with characteristic aroma and flavor are commercially recognized as oregano,with L.graveolens being the most widely distributed and economically important.Despite its relevance,few domesticated or semi-domesticated cultivars exist,and wild populations remain the main source of raw material,raising concerns regarding sustainability and quality standardization.The essential oil and oleoresins of L.graveolens possess recognized bioactivity,including antioxidant,antifungal,antibacterial,and anti-inflammatory properties,largely attributed to phenolic compounds such as thymol and carvacrol.Given the increasing global demand for natural bioactives and functional foods,optimizing cultivation practices is essential to enhance both the yield and phytochemical quality of this species.This study evaluated the effect of organic fertilization(0,5,10,and 15 t ha^(−1)of vermicompost)on the phenolic profile,flavonoid content,and antioxidant capacity of oregano oleoresin obtained from a semi-domesticated population across three harvests.The highest phenolic concentration(≈500 mg GAE g^(−1)extract)and greatest antioxidant activity(ABTS>3.5×10^(5)μmol TE g^(−1)extract)were observed at the 5 t ha^(−1)dose during the second harvest.Flavonoid content peaked in the third harvest(480-620 mg QE g^(−1)extract),whereas the unfertilized control exhibited the highest DPPH activity in the first harvest.Overall,the results indicate that vermicompost dosage and harvest timing substantially influence the functional quality of L.graveolens.Moderate organic fertilization,particularly 5 t ha^(−1),enhances the biosynthesis of bioactive secondary metabolites,underscoring its potential for sustainable production systems.展开更多
Forest ecosystems worldwide can be affected by extreme climatic events.Trees respond to these occurrences in multidimensional ways,involving various mechanisms,to deal with the effects and restore the forests to their...Forest ecosystems worldwide can be affected by extreme climatic events.Trees respond to these occurrences in multidimensional ways,involving various mechanisms,to deal with the effects and restore the forests to their optimal state.Such abilities are known as resilience.Tree ring analysis can be used to evaluate drought resilience.Analysis of dendrophenotypes,together with genetic studies,has become an essential tool for identifying drought resilient genotypes.This study aimed to determine the dendrogenomic resilience mechanisms in the fragmented,isolated,rare endemic Mexican species Picea martinezii and P.mexicana by analysis of annual rings and the associations with SNP markers identified by genotyping by sequencing(GBS).Increment cores and needles for GBS for resilience analysis were collected from P.martinezii trees in three populations,and from P.mexicana trees in two populations.The results show that fundamental dendrogenomic mechanisms were associated with drought resilience in P.martinezii and P.mexicana.PC1 in PCA for five outlier SNPs was linked to annual tracheid width variations in P.martinezii caused by severe drought events in 1962,1989,1998 and 2011.These five outlier SNPs were located in genes coding the proteins reticulon-like protein B22,pollen-specific leucine-rich repeat extension,ornithine decarboxylase like,LisH/CRA/RING-U-box domains-containing protein and proline transporter 2-like isoform X1,which are important in the dry stress tolerance metabolism involved in the resilience response in plants.The discovery of genetic markers associated with drought resilience highlights the importance of preserving genetic diversity.展开更多
The major aim of stroke therapy is to stimulate brain repair and improve behavioral recovery after cerebral ischemia.One option is to stimulate endogenous neurogenesis in the subventricular zone and direct the newly f...The major aim of stroke therapy is to stimulate brain repair and improve behavioral recovery after cerebral ischemia.One option is to stimulate endogenous neurogenesis in the subventricular zone and direct the newly formed neurons to the damaged area.However,only a small percentage of these neurons survive,and many do not reach the damaged area,possibly because the corpus callosum impedes the migration of subventricular zone-derived stem cells into the lesioned cortex.A second major obstacle to stem cell therapy is the strong inflammatory reaction induced by cerebral ischemia,whereby the associated phagocytic activity of brain macrophages removes both therapeutic cells and/or cell-based drug carriers.To address these issues,neurogenesis was electrically stimulated in the subventricular zone,followed by isolation of proliferating cells,including newly formed neurons,which were subsequently mixed with a nutritional hydrogel.This mixture was then transferred to the stroke cavity of day 14 post-stroke mice.We found that the performance of the treated animals improved in behavioral tests,including novel object,open field,hole board,grooming,and“time-to-feel”adhesive tape tests.Furthermore,immunostaining revealed that the stem cell marker nestin,the neuroepithelial marker Mash1,and the immature neuronal marker doublecortin-positive cells survived in the transplanted area for 2 weeks,possibly due to reduced phagocytic activity and supportive angiogenesis.These results clearly indicate that the transplantation of committed subventricular zone stem cells combined with a protective nutritional gel directly into the infarct cavity after the peak of stroke-induced neuroinflammation represents a feasible approach to improve neurorestoration after cerebral ischemia.展开更多
文摘For environmental applications,it is crucial to rationally design and synthesize photocatalysts with positive exciton splitting and interfacial charge transfer.Here,a novel Agbridged dual Z-scheme Ag/g-C_(3)N_(4)/CoNi-LDH plasmonic heterojunction was successfully synthesized using a simple method,with the goal of overcoming the common drawbacks of traditional photocatalysts such as weak photoresponsivity,rapid combination of photogenerated carriers,and unstable structure.These materials were characterized by XRD,FT-IR,SEM,TEM UV-Vis/DRS,and XPS to verify the structure and stability of the heterostructure.The pristine LDH,g-C_(3)N_(4),and Ag/g-C_(3)N_(4)/CoNi-LDH composite were investigated as photocatalysts for water remediation,an environmentally motivated process.Specifically,the photocatalytic degradation of tetracycline was studied as a model reaction.The performance of the supports and composite catalyst were determined by evaluating both the degradation and adsorption phenomenon.The influence of several experimental parameters such as catalyst loading,pH,and tetracycline concentrationwere evaluated.The current study provides important data for water treatment and similar environmental protection applications.
文摘<strong>Introduction:</strong> Chronic renal failure (CRF) is defined as glomerular filtration rate (GFR) less than 60 ml/min/1.73m<sup>2</sup> for at least three (3) months. Anemia is one of its most common complications. Anemia increases the risk factor for cardiovascular mortality by 18% per gram of hemoglobin loss. <strong>Objectives:</strong> To determine the prevalence and characteristics of this severe anemia, to determine the indications for transfusion, the complications related to this anemia, the evolution and the prognosis of these patients. <strong>Materials and Methods:</strong> This was a descriptive study with retrospective data collection over 18 months (January 1, 2017 to June 30, 2018) that included hospitalized CRF patients. Were included, non-dialyzed chronic renal failure patients with Hb ≤ 5 g/dl hospitalized during the said period. Not included were chronic renal failure patients with an Hb level ≥ 5 g/dl, those followed up and/or hospitalized outside the study period. <strong>Results:</strong> Among 1176 patients, 26 had severe anemia (Hb level ≤ 5 g/dl) on CRF, a prevalence of 2.21%. The mean age was 40 years ± 32.62 with extremes of 15 and 67 years. Seventeen women and 9 men. The etiology of chronic renal failure (CRF) was hypertensive vascular nephropathy in 50% of cases. CRF was end-stage in 18 patients (69.2%). The mean hemoglobin level was 4.10 g/dl ± 0.64 with extremes of 2 and 5 g/dl. The anemia was microcytic hypochromic in 50% and aregenerative (96.2%). The main symptoms were asthenia in 20 cases (76.9%), dizziness in 20 cases (76.9%), exertional dyspnea in 19 cases (73.1%). Signs of cardiac decompensation (n = 12) were jugular turgor 10 cases (38.5%), hepato-jugular reflux 06 cases (23.1%), mitral insufficiency murmur 06 cases (23.1%). The main complication was left ventricular hypertrophy 17 cases (77.3%). There was no correlation between anemia and sex (p = 0.291), age (p = 0.778), malaria (p = 0.158), etiology of CRF (p = 0.26). The evolution after treatment of anemia was favorable in 19 patients (73.1%), unfavorable in 02 patients (7.7%) and 05 deaths (19.2%). The deaths were of cardiovascular cause: left ventricular insufficiency 04 cases, stroke 01 case. <strong>Conclusion:</strong> Anemia is frequent in patients with chronic renal failure and remains an important risk factor for cardiovascular disease and poor general condition.
基金funded by TSRI Fund(CU_FRB640001_01_21_6).Amir Parnianifard would like to acknowledge the financial support by Second Century Fund(C2F),Chulalongkorn University,BangkokSupporting Project number(TURSP-2020/228),Taif University,Taif,Saudi Arabia for the financial support.
文摘With every passing day,the demand for data traffic is increasing,and this urges the research community not only to look for an alternating spectrum for communication but also urges radio frequency planners to use the existing spectrum efficiently.Cell sizes are shrinking with every upcoming communication generation,which makes base station placement planning even more complex and cumbersome.In order to make the next-generation cost-effective,it is important to design a network in such a way that it utilizes the minimum number of base stations while ensuring seamless coverage and quality of service.This paper aims at the development of a new simulation-based optimization approach using a hybrid metaheuristic and metamodel applied in a novel mathematical formulation of the multi-transmitter placement planning(MTPP)problem.We first develop a new mathematical programming model for MTPP that is flexible to design the locations for any number of transmitters.To solve this constrained optimization problem,we propose a hybrid approach using the radial basis function(RBF)metamodel to assist the particle swarm optimizer(PSO)by mitigating the associated computational burden of the optimization procedure.We evaluate the effectiveness and applicability of the proposed algorithm by simulating the MTPP model with two,three,four and five transmitters and estimating the Pareto front for optimal locations of transmitters.The quantitative results show that almost maximum signal coverage can be obtained with four transmitters;thus,it is not a wise idea to use higher number of transmitters in the model.Furthermore,the limitations and future works are discussed.
基金Supported by the National Natural Science Foundation of China(No.52273056)the Science and Technology Development Program of Jilin Province,China(No.YDZJ202501ZYTS305)。
文摘Electrochemical water splitting represents a sustainable technology for hydrogen(H_(2))production.However,its large-scale implementation is hindered by the high overpotentials required for both the cathodic hydrogen evolution reaction(HER)and the anodic oxygen evolution reaction(OER).Transition metal-based catalysts have garnered significant research interest as promising alternatives to noble-metal catalysts,owing to their low cost,tunable composition,and noble-metal-like catalytic activity.Nevertheless,systematic reviews on their application as bifunctional catalysts for overall water splitting(OWS)are still limited.This review comprehensively outlines the principal categories of bifunctional transition metal electrocatalysts derived from electrospun nanofibers(NFs),including metals,oxides,phosphides,sulfides,and carbides.Key strategies for enhancing their catalytic performance are systematically summarized,such as heterointerface engineering,heteroatom doping,metal-nonmetal-metal bridging architectures,and single-atom site design.Finally,current challenges and future research directions are discussed,aiming to provide insightful perspectives for the rational design of high-performance electrocatalysts for OWS.
基金supported by the National Natural Science Foundation of China,No.82001325Visiting Scholar Foundation of Shandong Province,No.20236-01(both to CS).
文摘Stroke is the leading cause of mortality globally,ultimately leading to severe,lifelong neurological impairments.Patients often suffer from a secondary cascade of damage,including neuroinflammation,cytotoxicity,oxidative stress,and mitochondrial dysfunction.Regrettably,there is a paucity of clinically available therapeutics to address these issues.Emerging evidence underscores the pivotal roles of astrocytes,the most abundant glial cells in the brain,throughout the various stages of ischemic stroke.In this comprehensive review,we initially provide an overview of the fundamental physiological functions of astrocytes in the brain,emphasizing their critical role in modulating neuronal homeostasis,synaptic activity,and blood-brain barrier integrity.We then delve into the growing body of evidence that highlights the functional diversity and heterogeneity of astrocytes in the context of ischemic stroke.Their well-established contributions to energy provision,metabolic regulation,and neurotransmitter homeostasis,as well as their emerging roles in mitochondrial recovery,neuroinflammation regulation,and oxidative stress modulation following ischemic injury,are discussed in detail.We also explore the cellular and molecular mechanisms underpinning these functions,with particular emphasis on recently identified targets within astrocytes that offer promising prospects for therapeutic intervention.In the final section of this review,we offer a detailed overview of the current therapeutic strategies targeting astrocytes in the treatment of ischemic stroke.These astrocyte-targeting strategies are categorized into traditional small-molecule drugs,microRNAs(miRNAs),stem cell-based therapies,cellular reprogramming,hydrogels,and extracellular vesicles.By summarizing the current understanding of astrocyte functions and therapeutic targeting approaches,we aim to highlight the critical roles of astrocytes during and after stroke,particularly in the pathophysiological development in ischemic stroke.We also emphasize promising avenues for novel,astrocyte-targeted therapeutics that could become clinically available options,ultimately improving outcomes for patients with stroke.
文摘In this study,we developed a novel bilayered scaffold consisting of a bottom layer composed of the Decellularized Bovine Pericardium(DP)coated with Polyaniline Nanoparticles(PANINPs)and a top layer made of an electrospun Poly(lactic-co-glycolic acid)/Gelatin(PLGA/Gel)membrane incorporated with Vascular Endothelial Growth Fac-tor(VEGF)and hawthorn extract.Functionally,the DP supplies native Extracellular Matrix(ECM)components and mechanical support,while PANINPs provide conductivity.The electrospun PLGA/Gel layer mimics fibrous ECM.It incorporates bioactives,with VEGF promoting pro-angiogenic stimulation and hawthorn extract enhanc-ing anticoagulant activity,as well as increasing surface hydrophilicity.The tissue adhesive ensures the interfacial integrity between the two layers.Decellularization efficiency was confirmed histologically using 4',6-diamidino-2-phenylindole(DAPI)and Hematoxylin-Eosin(H&E)staining.The DP exhibited a DNA content of 115.9±47.8 ng/mg DNA,compared to 982.88±395.42 ng/mg in Native Pericardium(NP).The PANINPs had an average par-ticle size of 104.94±13.7 nm.The conductivity of PANINPs-coated decellularized pericardium was measured to be 9.093±8.6×10-4 S/cm using the four-point probe method.PLGA/Gel membranes containing hawthorn extract(1%,5%,10%,and 15%w/v)and VEGF(0.1μg/mL,0.5μg/mL,and 1μg/mL)were fabricated by electrospinning,result-ing in fiber diameters between 850 and 1200 nm and pore sizes between 14 and 20μm.The anticoagulant efficiency of the membranes containing hawthorn extract reached 430 s in the Activated Partial Thromboplastin Time Assay(aPTT).Mechanical testing revealed a tensile strength of 22.70±6.33 MPa,an elongation of 53.58±10.63%,and Young's modulus of 0.67±0.10 MPa.The scaffold also exhibited over 91%cell viability and excellent cardiomyo-cyte adhesion.The hemolysis ratio was determined to be 0.421±0.191%,which confirms its blood compatibility.Our results indicate that the proposed bilayered scaffold can be a promising candidate for cardiac patch applications.
文摘With the proliferation of Internet of Things(IoT)devices,securing these interconnected systems against cyberattacks has become a critical challenge.Traditional security paradigms often fail to cope with the scale and diversity of IoT network traffic.This paper presents a comparative benchmark of classic machine learning(ML)and state-of-the-art deep learning(DL)algorithms for IoT intrusion detection.Our methodology employs a twophased approach:a preliminary pilot study using a custom-generated dataset to establish baselines,followed by a comprehensive evaluation on the large-scale CICIoTDataset2023.We benchmarked algorithms including Random Forest,XGBoost,CNN,and StackedLSTM.The results indicate that while top-performingmodels frombothcategories achieve over 99%classification accuracy,this metric masks a crucial performance trade-off.We demonstrate that treebased ML ensembles exhibit superior precision(91%)in identifying benign traffic,making them effective at reducing false positives.Conversely,DL models demonstrate superior recall(96%),making them better suited for minimizing the interruption of legitimate traffic.We conclude that the selection of an optimal model is not merely a matter of maximizing accuracy but is a strategic choice dependent on the specific security priority either minimizing false alarms or ensuring service availability.Thiswork provides a practical framework for deploying context-aware security solutions in diverse IoT environments.
文摘To ensure the efficient use of resources,particularly in water-scarce arid and semi-arid regions where abiotic stress threatens food security,assessing soil and climate suitability for specific crops is crucial.Simultaneously,food production must align with sustainable development goals by minimizing negative environmental impacts.Therefore,establishing agro-climatic suitability using a spatiotemporal approach is essential.This involves three key steps:first,determining the climatically appropriate months based on the species’requirements(temporal suitability),and second,establishing the soil suitability of specific plots(spatial suitability).Following this,quantifying crop evapotranspiration allows for optimized water use.This study used climatic and soil variables from diverse data sources to characterize the study area.Subsequently,suitability classes for Portulaca oleracea were determined based on existing literature.Our analysis concerning temporal suitability revealed that June and July are the optimal months for sowing this species in all of the municipalities.Spatially,approximately 30%of the agricultural land use of the study area exhibits a highly suitable class in most municipalities.Both dimensions,the temporal and the spatially,were validated through Chi square(χ^(2))Goodness-of-Fit test and theχ^(2)test of independence,respectively.Consequently,for a one-month production cycle during periods of high suitability,estimated evapotranspiration values are between 210 and 245 mm.In brief,the study area demonstrates favorable agro-climatic conditions for P.oleracea cultivation in specific months of the year according to parameters used,with potential in a large proportion of agricultural land and achievable water requirements.
基金the UGC,New Delhi,India for financial assistance via the UGC-Junior Research Fellowship(CSIR-UGC NET JULY 2024)(Student ID:241610090610)。
文摘The flow of a tetra-hybrid Casson nanofluid(Al_(2)O_(3)-CuO-TiO_(2)-Ag/H_(2)O)over a nonlinear stretching sheet is investigated.The Buongiorno model is used to account for thermophoresis and Brownian motion,while thermal radiation is incorporated to examine its influence on the thermal boundary layer.The governing partial differential equations(PDEs)are reduced to a system of nonlinear ordinary differential equations(ODEs)with fully non-dimensional similarity transformations involving all independent variables.To solve the obtained highly nonlinear system of differential equations,a novel Clique polynomial collocation method is applied.The analysis focuses on the effects of the Casson parameter,power index,radiation parameter,thermophoresis parameter,Brownian motion parameter,and Lewis number.The key findings show that thermal radiation intensifies the thermal boundary layer,the Casson parameter reduces the velocity,and the Lewis number suppresses the concentration with direct relevance to polymer processing,coating flows,electronic cooling,and biomedical applications.
文摘Rapid evolutions of the Internet of Electric Vehicles(IoEVs)are reshaping and modernizing transport systems,yet challenges remain in energy efficiency,better battery aging,and grid stability.Typical charging methods allow for EVs to be charged without thought being given to the condition of the battery or the grid demand,thus increasing energy costs and battery aging.This study proposes a smart charging station with an AI-powered Battery Management System(BMS),developed and simulated in MATLAB/Simulink,to increase optimality in energy flow,battery health,and impractical scheduling within the IoEV environment.The system operates through real-time communication,load scheduling based on priorities,and adaptive charging based on batterymathematically computed State of Charge(SOC),State of Health(SOH),and thermal state,with bidirectional power flow(V2G),thus allowing EVs’participation towards grid stabilization.Simulation results revealed that the proposed model can reduce peak grid load by 37.8%;charging efficiency is enhanced by 92.6%;battery temperature lessened by 4.4℃;SOH extended over 100 cycles by 6.5%,if compared against the conventional technique.By this way,charging time was decreased by 12.4% and energy costs dropped by more than 20%.These results showed that smart charging with intelligent BMS can boost greatly the operational efficiency and sustainability of the IoEV ecosystem.
基金financial support from the Yunnan Province Key Industries Science and Technology Special Project for Colleges and UniversitiesChina(No.FWCY-QYCT2024006)+6 种基金National Natural Science Foundation of China(Nos.52104351 and 52364051)Science and Technology Major Project of Yunnan Province,China(No.202202AG050007)the Yunnan Fundamental Research ProjectsChina(No.202401AT070314)the Key Technology Research and Development Program of Shandong Province,China(No.2023CXGC010903)Central Guidance Local Scientific and Technological Development Funds,China(No.202407AB110022)Yunnan Province Xingdian Talent Support Plan Project,China。
文摘Titanium exhibits outstanding properties,particularly,high specific strength and resistance to both high and low temperatures,earning it a reputation as the metal of the future.However,because of the highly reactive nature of titanium,metallic titanium production involves extensive procedures and high costs.Considering its advantages and limitations,the European Union has classified titanium metal as a critical raw material(CRM)of low category.The Kroll process is predominantly used to produce titanium;however,molten salt electrolysis(MSE)is currently being explored for producing metallic titanium at a low cost.Since 2000,electrolytic titanium production has undergone a wave of technological advancements.However,because of the intermediate and disproportionation reactions in the electrolytic titanium production process,the process efficiency and titanium purity according to industrial standards could not be achieved.Consequently,metallic titanium production has gradually diversified into employing technologies such as thermal reduction,MSE,and titanium alloy preparation.This study provides a comprehensive review of research advances in titanium metal preparation technologies over the past two decades,highlighting the challenges faced by the existing methods and proposing potential solutions.It offers useful insights into the development of low-cost titanium preparation technologies.
文摘Mexican oregano(Lippia graveolens Kunth)is an aromatic species of high culinary and medicinal relevance.In Mexico,more than 40 taxa with characteristic aroma and flavor are commercially recognized as oregano,with L.graveolens being the most widely distributed and economically important.Despite its relevance,few domesticated or semi-domesticated cultivars exist,and wild populations remain the main source of raw material,raising concerns regarding sustainability and quality standardization.The essential oil and oleoresins of L.graveolens possess recognized bioactivity,including antioxidant,antifungal,antibacterial,and anti-inflammatory properties,largely attributed to phenolic compounds such as thymol and carvacrol.Given the increasing global demand for natural bioactives and functional foods,optimizing cultivation practices is essential to enhance both the yield and phytochemical quality of this species.This study evaluated the effect of organic fertilization(0,5,10,and 15 t ha^(−1)of vermicompost)on the phenolic profile,flavonoid content,and antioxidant capacity of oregano oleoresin obtained from a semi-domesticated population across three harvests.The highest phenolic concentration(≈500 mg GAE g^(−1)extract)and greatest antioxidant activity(ABTS>3.5×10^(5)μmol TE g^(−1)extract)were observed at the 5 t ha^(−1)dose during the second harvest.Flavonoid content peaked in the third harvest(480-620 mg QE g^(−1)extract),whereas the unfertilized control exhibited the highest DPPH activity in the first harvest.Overall,the results indicate that vermicompost dosage and harvest timing substantially influence the functional quality of L.graveolens.Moderate organic fertilization,particularly 5 t ha^(−1),enhances the biosynthesis of bioactive secondary metabolites,underscoring its potential for sustainable production systems.
基金funding from the Mixed Fund of the National Council of Humanities,Sciences,and Technologies of Mexico and the National Forestry Commission(CONACYT-CONAFOR-2017-4-292615),awarded to Christian WehenkelSECIHTI provided a graduate scholarship to Carlos Alberto Segura Sanchez(776540).
文摘Forest ecosystems worldwide can be affected by extreme climatic events.Trees respond to these occurrences in multidimensional ways,involving various mechanisms,to deal with the effects and restore the forests to their optimal state.Such abilities are known as resilience.Tree ring analysis can be used to evaluate drought resilience.Analysis of dendrophenotypes,together with genetic studies,has become an essential tool for identifying drought resilient genotypes.This study aimed to determine the dendrogenomic resilience mechanisms in the fragmented,isolated,rare endemic Mexican species Picea martinezii and P.mexicana by analysis of annual rings and the associations with SNP markers identified by genotyping by sequencing(GBS).Increment cores and needles for GBS for resilience analysis were collected from P.martinezii trees in three populations,and from P.mexicana trees in two populations.The results show that fundamental dendrogenomic mechanisms were associated with drought resilience in P.martinezii and P.mexicana.PC1 in PCA for five outlier SNPs was linked to annual tracheid width variations in P.martinezii caused by severe drought events in 1962,1989,1998 and 2011.These five outlier SNPs were located in genes coding the proteins reticulon-like protein B22,pollen-specific leucine-rich repeat extension,ornithine decarboxylase like,LisH/CRA/RING-U-box domains-containing protein and proline transporter 2-like isoform X1,which are important in the dry stress tolerance metabolism involved in the resilience response in plants.The discovery of genetic markers associated with drought resilience highlights the importance of preserving genetic diversity.
基金supported by European Union Funding Programme,PNRR,No. 760058(to DMH)the UEFISCDI Project,No. PN-III-P4-IDPCE-2020-059(to APW)
文摘The major aim of stroke therapy is to stimulate brain repair and improve behavioral recovery after cerebral ischemia.One option is to stimulate endogenous neurogenesis in the subventricular zone and direct the newly formed neurons to the damaged area.However,only a small percentage of these neurons survive,and many do not reach the damaged area,possibly because the corpus callosum impedes the migration of subventricular zone-derived stem cells into the lesioned cortex.A second major obstacle to stem cell therapy is the strong inflammatory reaction induced by cerebral ischemia,whereby the associated phagocytic activity of brain macrophages removes both therapeutic cells and/or cell-based drug carriers.To address these issues,neurogenesis was electrically stimulated in the subventricular zone,followed by isolation of proliferating cells,including newly formed neurons,which were subsequently mixed with a nutritional hydrogel.This mixture was then transferred to the stroke cavity of day 14 post-stroke mice.We found that the performance of the treated animals improved in behavioral tests,including novel object,open field,hole board,grooming,and“time-to-feel”adhesive tape tests.Furthermore,immunostaining revealed that the stem cell marker nestin,the neuroepithelial marker Mash1,and the immature neuronal marker doublecortin-positive cells survived in the transplanted area for 2 weeks,possibly due to reduced phagocytic activity and supportive angiogenesis.These results clearly indicate that the transplantation of committed subventricular zone stem cells combined with a protective nutritional gel directly into the infarct cavity after the peak of stroke-induced neuroinflammation represents a feasible approach to improve neurorestoration after cerebral ischemia.
