ZC4H2 encodes a C4H2 type zinc-finger nuclear factor,the mutation of which has been associated with disorders with various clinical phenotypes in human,including developmental delay,intellectual disability and dystoni...ZC4H2 encodes a C4H2 type zinc-finger nuclear factor,the mutation of which has been associated with disorders with various clinical phenotypes in human,including developmental delay,intellectual disability and dystonia.ZC4H2 has been suggested to regulate spinal cord patterning in zebrafish as a co-factor for RNF220,an ubiquitin E3 ligase involved in Gli signaling.Here we showed that ZC4H2 and RNF220 knockout animals phenocopy each other in spinal patterning in both mouse and zebrafish,with mispatterned progenitor and neuronal domains in the ventral spinal cord.We showed evidence that ZC4H2 is required for the stability of RNF220 and also proper Gli ubiquitination and signaling in vivo.Our data provides new insights into the possible etiology of the neurodevelopmental impairments observed in ZC4H2-associated syndromes.展开更多
For the two classes of stochastic processes, namely, martingale difference sequences withconstant conditional variances and processes with independent increments, each square-inte-grable functional of the process has ...For the two classes of stochastic processes, namely, martingale difference sequences withconstant conditional variances and processes with independent increments, each square-inte-grable functional of the process has been shown to have chaos decomposition if and only ifthe process has the property of predictable representation. The definition of chaos is thesame as P. A. Meyer’s, that is polynomial functional in discrete parameter case and ortho-gonal stochastic multiple integral in continuous parameter case. The proofs mainly rely onthe necessary and sufficient conditions for the property of predictable representation forthese two classes of processes, obtained previously by the authors.展开更多
基金the National Natural Science Foundation of China(31871483 and 31671521 to B.M.,31500847 to P.M.,31771134 to N.S.,81571332 and 91232724 to Y.D.,and 31671509 to D.S.)the National Key R&D Program of China(2017YFA0104002 to Y.-Q.D.)Shanghai Municipal Science and Technology Major Project(2018SHZDZX01)and ZJLab.
文摘ZC4H2 encodes a C4H2 type zinc-finger nuclear factor,the mutation of which has been associated with disorders with various clinical phenotypes in human,including developmental delay,intellectual disability and dystonia.ZC4H2 has been suggested to regulate spinal cord patterning in zebrafish as a co-factor for RNF220,an ubiquitin E3 ligase involved in Gli signaling.Here we showed that ZC4H2 and RNF220 knockout animals phenocopy each other in spinal patterning in both mouse and zebrafish,with mispatterned progenitor and neuronal domains in the ventral spinal cord.We showed evidence that ZC4H2 is required for the stability of RNF220 and also proper Gli ubiquitination and signaling in vivo.Our data provides new insights into the possible etiology of the neurodevelopmental impairments observed in ZC4H2-associated syndromes.
基金Supported by the National Natural Science Foundation of China.
文摘For the two classes of stochastic processes, namely, martingale difference sequences withconstant conditional variances and processes with independent increments, each square-inte-grable functional of the process has been shown to have chaos decomposition if and only ifthe process has the property of predictable representation. The definition of chaos is thesame as P. A. Meyer’s, that is polynomial functional in discrete parameter case and ortho-gonal stochastic multiple integral in continuous parameter case. The proofs mainly rely onthe necessary and sufficient conditions for the property of predictable representation forthese two classes of processes, obtained previously by the authors.
