AIM: To determine the gene expression profile data for the whole liver during development of dimethylni-trosamine (DMN)-induced hepatic fibrosis.METHODS: Marker genes were identified for different types of hepatic cel...AIM: To determine the gene expression profile data for the whole liver during development of dimethylni-trosamine (DMN)-induced hepatic fibrosis.METHODS: Marker genes were identified for different types of hepatic cells, including hepatic stellate cells (HSCs), Kupffer cells (including other inflammatory cells), and hepatocytes, using independent temporal DNA microarray data obtained from isolated hepatic cells. RESULTS: The cell-type analysis of gene expression gave several key results and led to formation of three hypotheses: (1) changes in the expression of HSC-specific marker genes during fibrosis were similar to gene expression data in in vitro cultured HSCs, suggesting a major role of the self-activating characteristics of HSCs in formation of fibrosis; (2) expression of mast cell-specific marker genes reached a peak during liver fibrosis, suggesting a possible role of mast cells in formation of fibrosis; and (3) abnormal expression of hepatocyte-specific marker genes was found across several metabolic pathways during fibrosis, including sulfur-containing amino acid metabolism, fatty acid metabolism, and drug metabolism, suggesting a mechanistic relationship between these abnormalities and symptoms of liver fibrosis. CONCLUSION: Analysis of marker genes for specific hepatic cell types can identify the key aspects of fibro-genesis. Sequential activation of inflammatory cells and the self-supporting properties of HSCs play an important role in development of fibrosis.展开更多
A dynamic object behavior model based on computational reflection is proposed.This model consists of function level and meta level,the meta objects in meta level manage the base objects and behaviors in function level...A dynamic object behavior model based on computational reflection is proposed.This model consists of function level and meta level,the meta objects in meta level manage the base objects and behaviors in function level,including dynamic binding and unbinding of base object and behavior.We implement this model with RoleJava Language,which is our self linguistic extension of the Java Language.Meta Objects are generated automatically at compile\|time,this makes the reflecton mechanism transparent to programmers.Finally an example applying this model to a banking system is presented.展开更多
Using directional antennas in Wireless Ad hoc Networks (WANETs) offers great potential of reducing the radio interference, and improving the communication throughput. Directional antennas, however, introduces new prob...Using directional antennas in Wireless Ad hoc Networks (WANETs) offers great potential of reducing the radio interference, and improving the communication throughput. Directional antennas, however, introduces new problems in the wireless Media Access Control (MAC), that is, the deafness and new hidden terminal problem, which may cause severe performance degradation. To solve the problems, we propose an effective Circular RTR Directional MAC (CRDMAC) protocol for WANETs by using a sub-transmission channel and Ready to Receive (RTR) packets, which modifies the IEEE 802.11 Distributed Coordinated Function (DCF). The sub-channel avoids collisions to other ongoing transmission, and the RTR packets notify the neighbor nodes that the mutual transmission has been finished. We evaluate the CRDMAC protocol through simulations and the results show that the proposed protocol outperforms existing DMAC (directional MAC) protocol and the CRCM (Circular RTS and CTS MAC) protocol in terms of throughput and packet drop rate.展开更多
Reusing business process models and best practices can improve the productivity, quality and agility in the early development phases of enterprise software systems. To help developers reuse the business process models...Reusing business process models and best practices can improve the productivity, quality and agility in the early development phases of enterprise software systems. To help developers reuse the business process models and best practices, we propose a methodology and an integrated environment for business process modeling driven by the metamodel. Furthermore, we propose a process-template design method to unify the granularity and separate the commonality and variability of business processes so that business process models can be reused across different enterprise software systems. The proposed methodology enables to create reuse-oriented business process templates before the business process modeling. To support the proposed methodology, we developed an integrated environment for creating, reusing and verifying the business process models. As the key techniques, we describe the methodology and its integrated environment, including a metamodel and notations. We applied the methodology and integrated environment to an actual enterprise software development project, and evaluated that the productivity of business process modeling is improved by at least 46%. As the conclusion, this paper contributes to prove the effectiveness of the meta-model driven business process modeling methodology for the reuse of business process models.展开更多
we have developed ferroelectric capacitor fabrication technique to realize low-voltage and high-density ferroelectric random access memory （FRAM）. High temperature deposited IrOxtop electrode reveals high crystallin...we have developed ferroelectric capacitor fabrication technique to realize low-voltage and high-density ferroelectric random access memory （FRAM）. High temperature deposited IrOxtop electrode reveals high crystalline quality which drastically reduces the degradation of ferroelectric film by preventing hydrogen diffusion into ferroelectric film. This improvement enables us to commercialize highly-reliable 1T 1C FRAM with memory density of 4 Mb or larger.展开更多
Various kinds of new engineering technologies have been studied to realize the low-carbon and sustainable power supply systems all over the world.In actual implementation of these technologies,mostly,there are multipl...Various kinds of new engineering technologies have been studied to realize the low-carbon and sustainable power supply systems all over the world.In actual implementation of these technologies,mostly,there are multiple objectives with trade off relationships among each other,and also various constraints in the achievement of these objectives.Therefore,it should be essential to solve multiobjective optimization problems effectively in the applications of these new technologies in power systems.This paper proposes an improved method to realize multiobjective optimization for critical challenges in advanced power systems.To realize that,in an optimal dispersed generation installation problem,that is,one of effective measures for low-carbon power systems,various optimization methods and their combination methods are evaluated and a hybrid method for evolutionary algorithms was developed.The method can provide improved results compared with other state-of-the-art multi-objective optimization methods.展开更多
NAREGI is a 5-year Japanese National Grid Project during 2003--2007, whose chief aim is to develop a set of grid middleware to serve as a basis for future e-Science. NAREGI also aims to lead the way in standardization...NAREGI is a 5-year Japanese National Grid Project during 2003--2007, whose chief aim is to develop a set of grid middleware to serve as a basis for future e-Science. NAREGI also aims to lead the way in standardization of grid middleware, based on the OGSA architecture. Its super-scheduler is based on the proposed OGSA-EMS Architecture, in that it becomes the first working implementation that implements the documented component relationships within the OGSA-EMS architecture document v.l.0. Through the efforts and experience in the design and implementation, it has been confirmed that the documented OGSA-EMS architecture is quite feasible, but will require significant amount of refinement and speed improvements to finalize its detailed specifications. The super-scheduler also supports co-allocation across multiple sites to support automated execution of grid-based MPIs that execute across machines. Such a resource allocation requires sophisticated interactions between the OGSA-EMS components not covered in the current OGSA-EMS architecture, some of which are non-trivial. Overall, job scheduling with OGSA-EMS has proven to not only work, but also that its job allocation and execution time is within reasonable bounds.展开更多
In late 2018,the asteroid Ryugu was in the Sun's shadow during the superior solar conjunction phase.As the Sun-Earth-Ryugu angle decreased to below 3°,the Hayabusa2 spacecraft experienced 21 days of planned b...In late 2018,the asteroid Ryugu was in the Sun's shadow during the superior solar conjunction phase.As the Sun-Earth-Ryugu angle decreased to below 3°,the Hayabusa2 spacecraft experienced 21 days of planned blackout in the Earth-probe communication link.This was the first time a spacecraft had experienced solar conjunction while hovering around a minor body.For the safety of the spacecraft,a low energy transfer trajectory named Ayu was designed in the Hill reference frame to increase its altitude from 20 to 110 km.The trajectory was planned with the newly developed optNEAR tool and validated with real time data.This article shows the results of the conjunction operation,from planning to fight data.展开更多
文摘AIM: To determine the gene expression profile data for the whole liver during development of dimethylni-trosamine (DMN)-induced hepatic fibrosis.METHODS: Marker genes were identified for different types of hepatic cells, including hepatic stellate cells (HSCs), Kupffer cells (including other inflammatory cells), and hepatocytes, using independent temporal DNA microarray data obtained from isolated hepatic cells. RESULTS: The cell-type analysis of gene expression gave several key results and led to formation of three hypotheses: (1) changes in the expression of HSC-specific marker genes during fibrosis were similar to gene expression data in in vitro cultured HSCs, suggesting a major role of the self-activating characteristics of HSCs in formation of fibrosis; (2) expression of mast cell-specific marker genes reached a peak during liver fibrosis, suggesting a possible role of mast cells in formation of fibrosis; and (3) abnormal expression of hepatocyte-specific marker genes was found across several metabolic pathways during fibrosis, including sulfur-containing amino acid metabolism, fatty acid metabolism, and drug metabolism, suggesting a mechanistic relationship between these abnormalities and symptoms of liver fibrosis. CONCLUSION: Analysis of marker genes for specific hepatic cell types can identify the key aspects of fibro-genesis. Sequential activation of inflammatory cells and the self-supporting properties of HSCs play an important role in development of fibrosis.
基金Supported by the National Natural Science Foundation of China(60373086)
文摘A dynamic object behavior model based on computational reflection is proposed.This model consists of function level and meta level,the meta objects in meta level manage the base objects and behaviors in function level,including dynamic binding and unbinding of base object and behavior.We implement this model with RoleJava Language,which is our self linguistic extension of the Java Language.Meta Objects are generated automatically at compile\|time,this makes the reflecton mechanism transparent to programmers.Finally an example applying this model to a banking system is presented.
基金supported by the Grant-in-Aid for Scientific Research of Japan Society for Promotion of Science(JSPS)Collaboration Research Grant of National Institute of Informatics (NII) ,Japan
文摘Using directional antennas in Wireless Ad hoc Networks (WANETs) offers great potential of reducing the radio interference, and improving the communication throughput. Directional antennas, however, introduces new problems in the wireless Media Access Control (MAC), that is, the deafness and new hidden terminal problem, which may cause severe performance degradation. To solve the problems, we propose an effective Circular RTR Directional MAC (CRDMAC) protocol for WANETs by using a sub-transmission channel and Ready to Receive (RTR) packets, which modifies the IEEE 802.11 Distributed Coordinated Function (DCF). The sub-channel avoids collisions to other ongoing transmission, and the RTR packets notify the neighbor nodes that the mutual transmission has been finished. We evaluate the CRDMAC protocol through simulations and the results show that the proposed protocol outperforms existing DMAC (directional MAC) protocol and the CRCM (Circular RTS and CTS MAC) protocol in terms of throughput and packet drop rate.
文摘Reusing business process models and best practices can improve the productivity, quality and agility in the early development phases of enterprise software systems. To help developers reuse the business process models and best practices, we propose a methodology and an integrated environment for business process modeling driven by the metamodel. Furthermore, we propose a process-template design method to unify the granularity and separate the commonality and variability of business processes so that business process models can be reused across different enterprise software systems. The proposed methodology enables to create reuse-oriented business process templates before the business process modeling. To support the proposed methodology, we developed an integrated environment for creating, reusing and verifying the business process models. As the key techniques, we describe the methodology and its integrated environment, including a metamodel and notations. We applied the methodology and integrated environment to an actual enterprise software development project, and evaluated that the productivity of business process modeling is improved by at least 46%. As the conclusion, this paper contributes to prove the effectiveness of the meta-model driven business process modeling methodology for the reuse of business process models.
文摘we have developed ferroelectric capacitor fabrication technique to realize low-voltage and high-density ferroelectric random access memory （FRAM）. High temperature deposited IrOxtop electrode reveals high crystalline quality which drastically reduces the degradation of ferroelectric film by preventing hydrogen diffusion into ferroelectric film. This improvement enables us to commercialize highly-reliable 1T 1C FRAM with memory density of 4 Mb or larger.
文摘Various kinds of new engineering technologies have been studied to realize the low-carbon and sustainable power supply systems all over the world.In actual implementation of these technologies,mostly,there are multiple objectives with trade off relationships among each other,and also various constraints in the achievement of these objectives.Therefore,it should be essential to solve multiobjective optimization problems effectively in the applications of these new technologies in power systems.This paper proposes an improved method to realize multiobjective optimization for critical challenges in advanced power systems.To realize that,in an optimal dispersed generation installation problem,that is,one of effective measures for low-carbon power systems,various optimization methods and their combination methods are evaluated and a hybrid method for evolutionary algorithms was developed.The method can provide improved results compared with other state-of-the-art multi-objective optimization methods.
文摘NAREGI is a 5-year Japanese National Grid Project during 2003--2007, whose chief aim is to develop a set of grid middleware to serve as a basis for future e-Science. NAREGI also aims to lead the way in standardization of grid middleware, based on the OGSA architecture. Its super-scheduler is based on the proposed OGSA-EMS Architecture, in that it becomes the first working implementation that implements the documented component relationships within the OGSA-EMS architecture document v.l.0. Through the efforts and experience in the design and implementation, it has been confirmed that the documented OGSA-EMS architecture is quite feasible, but will require significant amount of refinement and speed improvements to finalize its detailed specifications. The super-scheduler also supports co-allocation across multiple sites to support automated execution of grid-based MPIs that execute across machines. Such a resource allocation requires sophisticated interactions between the OGSA-EMS components not covered in the current OGSA-EMS architecture, some of which are non-trivial. Overall, job scheduling with OGSA-EMS has proven to not only work, but also that its job allocation and execution time is within reasonable bounds.
文摘In late 2018,the asteroid Ryugu was in the Sun's shadow during the superior solar conjunction phase.As the Sun-Earth-Ryugu angle decreased to below 3°,the Hayabusa2 spacecraft experienced 21 days of planned blackout in the Earth-probe communication link.This was the first time a spacecraft had experienced solar conjunction while hovering around a minor body.For the safety of the spacecraft,a low energy transfer trajectory named Ayu was designed in the Hill reference frame to increase its altitude from 20 to 110 km.The trajectory was planned with the newly developed optNEAR tool and validated with real time data.This article shows the results of the conjunction operation,from planning to fight data.
