Language anxiety and language motivation have been studied extensively by experts in foreign language （FL） learning. Both of these constructs have been found to be closely correlated to FL achievement. In this artic...Language anxiety and language motivation have been studied extensively by experts in foreign language （FL） learning. Both of these constructs have been found to be closely correlated to FL achievement. In this article, the author has reviewed foreign language anxiety, language motivation and the relationship between language motivation and language anxiety.展开更多
Pragmatics has gotten more and more attention since its decades'long history. As a branch of studying linguistics, the studying of pragmatics is focusing on how to understanding and using language in special conte...Pragmatics has gotten more and more attention since its decades'long history. As a branch of studying linguistics, the studying of pragmatics is focusing on how to understanding and using language in special context, and to achieve the purpose that using foreign language to communicate. Pragmatics makes a new road to solve this problem. This paper is focusing on the relationship between pragmatics and foreign language teaching, the using and the enlightenment. Then we can get more methods to improve the foreign language teaching.展开更多
As an important means of the internationalization of the nation’s literature,translation is also a process of transplanting and transmission of cultures.Tess of the d’Urbervilles is one of the masterpieces of Thomas...As an important means of the internationalization of the nation’s literature,translation is also a process of transplanting and transmission of cultures.Tess of the d’Urbervilles is one of the masterpieces of Thomas Hardy who was a brilliant realism writer in Victoria period.ZhangGuruo had been called“the professor of Thomas Hardy studies”whose translated version had received many great comments in other fields.The author is trying to explore the special identities and problems in the version translated by Zhang Guruo by the angles of domestication and foreignization,and their added questions about the translation strategies.展开更多
The meaning of the term“reduction”in Double Reduction Policy implores teachers to reflect on their teaching process and improve teaching efficiency.Not only should the quantity be reduced,but so should the behavior....The meaning of the term“reduction”in Double Reduction Policy implores teachers to reflect on their teaching process and improve teaching efficiency.Not only should the quantity be reduced,but so should the behavior.Having a comprehensive understanding of the students’learning process is actually a form of science.Therefore,we need to study and enhance its development[1].In order to reduce the learning burden and increase the efficiency of classroom teaching,we must clearly identify the inefficient and ineffective behaviors in classroom teaching,so as to avoid the following situations:a lack of deep thinking,a lack of ability in lesson preparation,fragmentation of questions and answers,a lack of questions that highlight the key points,anticlimax teaching process,and the habit of running over time in class[2,3].On this basis,this paper elaborates the current education state and clarifies the basic requirements of effective classroom teaching.Meanwhile,to reduce students’workload and increase the efficiency in carrying out assignments,much attention should be paid to optimizing assignment design and refining homework review and feedback.The purpose is to assign homework with an appropriate amount(achievable),precision(targeted),and suitability(personalized).Putting an end to the repetitious and unified training is not enough to improve the effect.展开更多
Chinese learning in primary school is an important stage to develop students' intelligence, cultivate their comprehensive ability to use language and accumulate Chinese knowledge. Incentive education is a further ...Chinese learning in primary school is an important stage to develop students' intelligence, cultivate their comprehensive ability to use language and accumulate Chinese knowledge. Incentive education is a further requirement of our country's quality education concept for primary school Chinese education at the stage of compulsory education. Scientific incentive education can not only motivate students' learning enthusiasm, but also enable students to establish self-confidence and enhance willpower. This paper discusses the application of scientific incentive education in Chinese teaching in primary schools for reference.展开更多
Reading ability is one of the most important abilities in Chinese teaching in primary school, and it is inextricably related to writing ability, oral communication ability and logical construction ability. How to comb...Reading ability is one of the most important abilities in Chinese teaching in primary school, and it is inextricably related to writing ability, oral communication ability and logical construction ability. How to combine the physical and mental development of students at the current stage to build a more efficient reading teaching mode in the actual reading teaching has become the teaching goal that primary school Chinese teachers need to explore together at this stage. In the context of the new curriculum reform, teachers need to further optimize and adjust the teaching philosophy and teaching methods of Chinese in primary schools. Relevant education departments also put forward strict requirements for reading teaching in primary schools. The primary school stage is a critical period for students to begin to develop their mind and body and consolidate their logical thinking. Therefore, teachers need to carefully guide students to deeply understand in the actual reading process, and then explore their own reading methods. Based on the reading foundation of primary school students and the importance of reading ability for primary school students, this paper explores and analyzes the teaching optimization strategies on how to effectively improve the efficiency of classroom teaching in primary school reading teaching.展开更多
The mortality rate ofAcinetobacter baumannii is as high as 47%,This is inseparable From its strong resistance to carbapenems,polymyxins,aminoglycosides,quinolone antibiotics.This article will analyze the resistance of...The mortality rate ofAcinetobacter baumannii is as high as 47%,This is inseparable From its strong resistance to carbapenems,polymyxins,aminoglycosides,quinolone antibiotics.This article will analyze the resistance of Acinetobacter baumannii to carbapenem antibiotics(meropenem and imipenem)and explore why Acinetobacter baumannii is so resistant.The data I used comes from the NCBI database,which includes six resistant groups(R)to meropenem and imipenem,and five sensitive groups(S).The level of the resistant group is complete genome,three sensitive groups are contig,and two are complete genome.Subsequently,I used Prokka in Galaxy to convert the Fasta.file into various forms such as Faa,gbk,ffn.After performing Fisher's test on all GFF files,I obtained the result chart,which includes the search for relevant domains and protein descriptions on Interpro using the chart.ProteinPlus also performed drug pocket prediction and constructed protein models using Swissmodel,as well as different multi sequence comparisons.Finally,I analyzed the functions of the proteins corresponding to the genes specific to the resistance group and the reasons for the development of drug resistance,making future research on the drug resistance of Acinetobacter baumannii easier.And further research can be conducted on the drug pocket in the protein ofAcinetobacter baumannii that has developed resistance,and drugs can be administered.展开更多
Aiming at the pain points of visually impaired people during travel,this research innovatively transforms an industrial quadruped robot into a guide dog device.By transplanting the PCS-9180 motion control system(1.7 m...Aiming at the pain points of visually impaired people during travel,this research innovatively transforms an industrial quadruped robot into a guide dog device.By transplanting the PCS-9180 motion control system(1.7 m/s,IP66),and integrating a multi-modal perception network with a lightweight YOLO11 model.Tests show that the pass-through rate in complex terrains is 98%,the response delay is 0.3 seconds,and the cost is 50%that of a guide dog.The research verifies the social value of the transformation of industrial robot technology.展开更多
With the progress of information technology,the digital transformation of enterprises has developed into a key strategy to improve competitiveness.This paper studies the influence of digital transformation of enterpri...With the progress of information technology,the digital transformation of enterprises has developed into a key strategy to improve competitiveness.This paper studies the influence of digital transformation of enterprises on the quality of accounting information and its countermeasures,discusses how digital transformation reshapes the ability of accounting information processing,transparency,sharing,and decision support,and analyzes the challenges in technology,management,and data security during this period.Through in-depth analysis,this paper puts forward a series of targeted countermeasures,including strengthening technology and system construction,optimizing management and processes,strengthening data security and privacy protection,and promoting the improvement of laws and standards,hoping to provide practical guidance for improving the quality of accounting information in the digital transformation of enterprises.展开更多
The extensive application of artificial intelligence(AI)technology is profoundly affecting the ecology of education.To analyze the advantages and disadvantages of AI for the professional growth of students,this study ...The extensive application of artificial intelligence(AI)technology is profoundly affecting the ecology of education.To analyze the advantages and disadvantages of AI for the professional growth of students,this study systematically analyzed the potential dual impacts of AI in higher education from two dimensions,namely academic ability and thinking patterns.Results indicated AI facilitated the development of students by improving learning efficiency and optimizing the integration of resources.However,it simultaneously aggravated the crisis of academic integrity and the inertia of thinking.In responding to these issues,this study proposed an integrated framework that included management,guidance,and standardization.This framework would facilitate the positive interaction between AI and education,contributing to the professional development of students.展开更多
This paper systematically studies the current practical application status,existing problems and optimization suggestions of 3D printing technology in spacecraft manufacturing.Research shows that this technology has b...This paper systematically studies the current practical application status,existing problems and optimization suggestions of 3D printing technology in spacecraft manufacturing.Research shows that this technology has been successfully applied to the manufacturing of key components such as rocket engines and satellite structures,demonstrating advantages like lightweight and rapid prototyping.However,it still faces core challenges such as material performance,process stability,adaptability to space environments,and industrialization costs.In response to these issues,this paper proposes three optimization suggestions:enhancing manufacturing reliability by developing aerospace-specific materials,optimizing process parameters,and establishing a quality traceability system.Surface modification technology and topological optimization design are adopted to enhance the adaptability to the spatial environment,and a space-ground integrated verification method is constructed.Reduce industrialization costs through the localization of materials,modular production,and the construction of a standardized system.Research has confirmed that implementing these measures can reduce the performance dispersion of 3D-printed aerospace components by more than 50%,increase their in-orbit lifespan by three times,and lower production costs by 30-40%.The research results of this paper provide a systematic technical route and industrialization solution for the large-scale application of 3D printing technology in the aerospace field,which has significant reference value for promoting the innovation of aerospace manufacturing models.展开更多
This study analyzes Agatha Christie’s mystery novel And Then There Were None from five dimensions—the nursery rhyme,Soldier Island,role of characters,death and psychological interaction—to explore its multi-dimensi...This study analyzes Agatha Christie’s mystery novel And Then There Were None from five dimensions—the nursery rhyme,Soldier Island,role of characters,death and psychological interaction—to explore its multi-dimensional metaphors and their deeper connotations.The key findings reveal that the nursery rhyme serves as a narrative thread,symbolizing both a fate-driven trial and societal rules manipulating individual destinies;Soldier Island’s isolation mirrors moral problem and emotional detachment in modern society;the characters,linked to their crimes and deaths,embody universal human flaws;death acts as both a form of justice and a critique of civilization’s fragility;the psychological struggles among the characters expose the collapse of morality under survival crises.By decoding these interconnected metaphors,the study interprets the work’s thematic framework of Sin and Punishment,offering insights into tensions between societal norms and individual existence today.展开更多
Based on provincial panel data of water footprint and grey water footprint, and with the help of data envelopment analysis model considering and without considering the unde- sirable output, this paper estimates the w...Based on provincial panel data of water footprint and grey water footprint, and with the help of data envelopment analysis model considering and without considering the unde- sirable output, this paper estimates the water resources utilization efficiency in China from 1997 to 2011. The spatial weighting matrix based on economy-spatial distance function is established to discuss spatial autocorrelation of water resources utilization efficiency. With the help of absolute/3-convergence model, this paper concludes that there exists/%convergence in the water resources utilization efficiency. Under the conditions of considering and without considering the undesirable output, it takes about 52.6 and 5.6 years respectively to achieve the extent of half of convergence. By mean of the spatial Durbin econometric model, this paper studies spatial spillover effects of the provincial water resources utilization efficiency in China. The results are as follows. 1） With considering and without considering the undesir- able output, there is significant spatial correlation in provincial water resource efficiency in China. 2） Under the two cases, the spatial autoregressive coefficients （p） are 0.278 and 0.507 respectively, at 1% significance level. There exist the spatial spillover effects of provin- cial water resources utilization efficiency. 3） With considering the undesirable output, these factors of the education funds, the transportation infrastructure, and the industrial and agri- cultural water consumption proportion have positive impacts. These factors of foreign direct investment, the industry value-added water consumption per ten thousand yuan, per capita water consumption, and the total precipitation have negative impacts. 4） Without considering the undesirable output, the factor of GDP per laborer has a greater positive significant influ- ence on the water resources utilization efficiency. However the facts of industry value-added water consumption in ten thousand yuan and the transportation infrastructure have no sig- nificant influence. 5） Regardless of undesirable output of water resources utilization efficiency the assessment of the present real water resources utilization in China will be distorted and policy-making will be misled. The water efficiency measure considering environmental factors （such as gray water footprint） is more reasonable.展开更多
Wear is a major factor of disc cutters’ failure. No current theory offers a standard for the prediction of disc cutter wear yet. In the field the wear prediction method commonly used is based on the excavation length...Wear is a major factor of disc cutters’ failure. No current theory offers a standard for the prediction of disc cutter wear yet. In the field the wear prediction method commonly used is based on the excavation length of tunnel boring machine（TBM） to predict the disc cutter wear and its wear law, considering the location number of each disc cutter on the cutterhead（radius for installation）; in theory, there is a prediction method of using arc wear coefficient. However, the preceding two methods have their own errors, with their accuracy being 40% or so and largely relying on the technicians’ experience. Therefore, radial wear coefficient, axial wear coefficient and trajectory wear coefficient are defined on the basis of the operating characteristics of TBM. With reference to the installation and characteristics of disc cutters, those coefficients are modified according to penetration, which gives rise to the presentation of comprehensive axial wear coefficient, comprehensive radial wear coefficient and comprehensive trajectory wear coefficient. Calculation and determination of wear coefficients are made with consideration of data from a segment of TBM project（excavation length 173 m）. The resulting wear coefficient values, after modification, are adopted to predict the disc cutter wear in the follow-up segment of the TBM project（excavation length of 5621 m）. The prediction results show that the disc cutter wear predicted with comprehensive radial wear coefficient and comprehensive trajectory wear coefficient are not only accurate（accuracy 16.12%） but also highly congruous, whereas there is a larger deviation in the prediction with comprehensive axial wear coefficient（accuracy 41%, which is in agreement with the prediction of disc cutters’ life in the field）. This paper puts forth a new method concerning prediction of life span and wear of TBM disc cutters as well as timing for replacing disc cutters.展开更多
Circular RNAs (circRNAs) are generated by head-to-tail splicing and are ubiquitously expressed in all multicellular organisms. Their important biological functions are increasingly recognized. Cerebral ischemia reperf...Circular RNAs (circRNAs) are generated by head-to-tail splicing and are ubiquitously expressed in all multicellular organisms. Their important biological functions are increasingly recognized. Cerebral ischemia reperfusion injury-induced brain microvascular endothelial cell dysfunction is an initial stage of blood-brain barrier disruption. The expression profile and potential function of circRNAs in brain microvascular endothelial cells is unknown. Rat brain microvascular endothelial cells were extracted and cultured in glucose-free medium for 4 hours with 5% CO2 and 95% N2, and the medium was then replaced with complete growth medium for 6 hours. The RNA in these cells was then extracted. The circRNA was identified by Find_circ and CIRI2 software. Functional and pathway enrichment analysis of genes that were common to differentially expressed mRNAs and circRNA host genes was performed by the Database for Annotation, Visualization and Integrated Discovery Functional Annotation Tool. Miranda software was used to predict microRNAs that were potentially sponged by circRNAs. Furthermore, cytoscape depicted the circR-NA-microRNA interaction network. The results showed that there were 1288 circRNAs in normal and oxygen-glucose deprived/recovered primary brain microvascular endothelial cells. There are 211 upregulated and 326 downregulated differentially expressed circRNAs. The host genes of these differentially expressed circRNAs overlapped with those of differentially expressed mRNAs. The shared genes were further studied by functional enrichment analyses, which revealed that circRNAs may contribute to calcium ion function and the cyclic guanosine 3′,5′-monophosphate (CAMP) dependent protein kinase (PKα) signaling pathway. Next, quantitative reverse transcription polymerase chain reaction assays were performed to detect circRNA levels transcribed from the overlapping host genes. Eight out of the ten circRNAs with the highest fold-change identified by sequencing were successfully verified. Subsequently, the circRNA-microRNA interaction networks of these eight circRNAs were explored by bioinformatic analysis. These results demonstrate that altered circRNAs may be important in the pathogenesis of cerebral ischemia reperfusion injury and consequently may also be potential therapeutic targets for cerebral ischemia diseases. All animal experiments were approved by the Chongqing Medical University Committee on Animal Research, China (approval No. CQMU20180086) on March 22, 2018.展开更多
An earthquake in the Jiuzhaigou area caused numerous secondary disasters, such as rolling stones, land collapse, landslides and debris flow, which badly affected the safety of human settlements and influenced the spat...An earthquake in the Jiuzhaigou area caused numerous secondary disasters, such as rolling stones, land collapse, landslides and debris flow, which badly affected the safety of human settlements and influenced the spatial layout of the post-disaster reconstruction. Therefore, carrying out assessments of land and identifying a suitable zone for human habitats were very important. This research creates the territorial suitability assessment and function zoning conceptual model in the earthquake-stricken area, and the new methods of the territorial suitability evaluation system were used to divide the spatial functional zones of the earthquake stricken area, which provide a theoretical guidance and decisionmaking basis for the reconstruction of the disaster area. The results showed that:(1) The Jiuzhaigou earthquake-stricken area comprises of an ecological area that has a high level of importance to the ecosystem. In the earthquake-stricken area, 65% of national land is at an altitude of 3000-4000 m, and therefore not suitable for a high level of intensive reconstruction, but reconstructed in an eco-friendly manner.(2) The zone suitable for reconstruction comprises mainly of the river valley and the flat terrain of western parts. The land with low suitability is mainly located on steep terrain, such as highmountains and low gullies. The geographic and geomorphic conditions limit the spread of a suitable reconstruction zone.(3) The earthquake-stricken area mainly comprises of a tourism industry gathering area, population gathering area, agriculture and animal husbandry development area, and ecological preservation area with areas of 76 km^2, 44 km^2, 1591 km^2 and 7512 km^2, respectively. Scientifically zoning the reconstruction areas using scientific evaluation may provide guidance for the location of reconstruction sites.展开更多
AIM:To understand the complex reaction of gastric inflammation induced by Helicobacter pylori(H pylori) in a systematic manner using a protein interaction network. METHODS:The expression of genes significantly changed...AIM:To understand the complex reaction of gastric inflammation induced by Helicobacter pylori(H pylori) in a systematic manner using a protein interaction network. METHODS:The expression of genes significantly changed on microarray during H pylori infection was scanned from the web literary database and translated into proteins.A network of protein interactions was constructed by searching the primary interactions of selected proteins.The constructed network was mathematically analyzed and its biological function was examined.In addition,the nodes on the network were checked to determine if they had any further functional importance or relation to other proteins by extending them. RESULTS:The scale-free network showing the relationship between inflammation and carcinogenesis was constructed.Mathematical analysis showed hub and bottleneck proteins,and these proteins were mostly related to immune response.The network contained pathways and proteins related to H pylori infection,such as the JAK-STAT pathway triggered by interleukins.Activation of nuclear factor (NF)-κB,TLR4,and other proteins known to function as core proteins of immune response were also found. These immune-related proteins interacted on the network with pathways and proteins related to the cell cycle,cell maintenance and proliferation,andtranscription regulators such as BRCA1,FOS,REL,and zinc finger proteins.The extension of nodes showed interactions of the immune proteins with cancer- related proteins.One extended network,the core network,a summarized form of the extended network, and cell pathway model were constructed. CONCLUSION:Immune-related proteins activated by H pylori infection interact with proto-oncogene proteins.The hub and bottleneck proteins are potential drug targets for gastric inflammation and cancer.展开更多
Two variable charge soils were incubated with biochars derived from straws of peanut, soybean, canola, and rice to investigate the effect of the biochars on their chemical properties and Pb（II） adsorption using batc...Two variable charge soils were incubated with biochars derived from straws of peanut, soybean, canola, and rice to investigate the effect of the biochars on their chemical properties and Pb（II） adsorption using batch experiments. The results showed soil cation exchange capacity （CEC） and pH significantly increased after 30 d of incubation with the biochars added. The incorporation of the biochars markedly increased the adsorption of Pb（II）, and both the electrostatic and non-electrostatic adsorption mechanisms contributed to Pb（II） adsorption by the variable charge soils. Adsorption isotherms illustrated legume- straw derived biochars more greatly increased Pb（II） adsorption on soils through the non-electrostatic mechanism via the formation of surface complexes between Pb（II） and acid functional groups of the biochars than did non-legume straw biochars. The adsorption capacity of Pb（II） increased, while the desorption amount slightly decreased with the increasing suspension pH for the studied soils, especially in a high suspension pH, indicating that precipitation also plays an important role in immobilizing Pb（II） to the soils.展开更多
High-sensitivity detection of porphyrin in blood is very important for the early diagnosis and treatment of porphyria.Based on the advantages of longer luminescence lifetime and lower background interference,organic a...High-sensitivity detection of porphyrin in blood is very important for the early diagnosis and treatment of porphyria.Based on the advantages of longer luminescence lifetime and lower background interference,organic afterglow molecular porphyrin detection probes were developed,but these probes show poor water solubility and insufficient luminescence intensity.Herein,we present an afterglow nanoprobe(Eu-NP)for porphyria detection in whole blood.The luminescent substance(europium complex)and the organic vinyl co mpound reacted with singlet oxygen(^(1)O_(2))were selected for encapsulation in polystyrene spheres.Eu-NP can respond to^(1)O_(2)produced by porphyrins,and the detection signals can be obtained by the emission of the afterglow Eu^(3+)-emissive nanosensor.Eu-NP can achieve high-sensitivity detection of porphyrin,and the lowest detection limit reaches 0.29μmol/L.The porphyrin detection in whole blood samples is consistent with clinical diagnosis results.Compared with the organic afterglow molecule,the Eu-NPs constructed in this work show a higher signal-to-noise ratio and sensitivity of porphyria detection.展开更多
Melatonin(MLT)is a hormonal substance found in many organisms and can improve plant stress resistance.In this study,the japonica rice variety Y32 and indica rice variety NJ6 were cultivated in hydroponics under differ...Melatonin(MLT)is a hormonal substance found in many organisms and can improve plant stress resistance.In this study,the japonica rice variety Y32 and indica rice variety NJ6 were cultivated in hydroponics under different concentrations of CdCl2 at the two-leaf stage.The growth,physiological and biochemical responses of the seedlings and the expression of cadmium(Cd)-related genes under exogenous melatonin(MLT)treatment were assessed.The results indicated that Cd stress destroyed the dynamic balance between reactive oxygen species(ROS)production and removal,resulting in ROS accumulation,membrane lipid peroxidation,and impaired growth and development.Following the application of exogenous MLT to rice seedlings,increases in plant biomass including both underground and above-ground areas were observed.MLT also scavenged the inhibition of superoxide dismutase(SOD)and peroxidase(POD)in a concentration dependent manner in response to Cd stress.Catalase(CAT)activity and malondialdehyde(MDA)expression also decreased following MLT treatment.Amongst the six Cd-related genes assessed,five genes were downregulated and one was up-regulated in response to MLT treatment.Taken together,these data demonstrate that MLT improves the resilience of rice seedlings at the biochemical,physiological,and molecular levels,and diminishes the damage caused by Cd stress.展开更多
文摘Language anxiety and language motivation have been studied extensively by experts in foreign language （FL） learning. Both of these constructs have been found to be closely correlated to FL achievement. In this article, the author has reviewed foreign language anxiety, language motivation and the relationship between language motivation and language anxiety.
文摘Pragmatics has gotten more and more attention since its decades'long history. As a branch of studying linguistics, the studying of pragmatics is focusing on how to understanding and using language in special context, and to achieve the purpose that using foreign language to communicate. Pragmatics makes a new road to solve this problem. This paper is focusing on the relationship between pragmatics and foreign language teaching, the using and the enlightenment. Then we can get more methods to improve the foreign language teaching.
文摘As an important means of the internationalization of the nation’s literature,translation is also a process of transplanting and transmission of cultures.Tess of the d’Urbervilles is one of the masterpieces of Thomas Hardy who was a brilliant realism writer in Victoria period.ZhangGuruo had been called“the professor of Thomas Hardy studies”whose translated version had received many great comments in other fields.The author is trying to explore the special identities and problems in the version translated by Zhang Guruo by the angles of domestication and foreignization,and their added questions about the translation strategies.
文摘The meaning of the term“reduction”in Double Reduction Policy implores teachers to reflect on their teaching process and improve teaching efficiency.Not only should the quantity be reduced,but so should the behavior.Having a comprehensive understanding of the students’learning process is actually a form of science.Therefore,we need to study and enhance its development[1].In order to reduce the learning burden and increase the efficiency of classroom teaching,we must clearly identify the inefficient and ineffective behaviors in classroom teaching,so as to avoid the following situations:a lack of deep thinking,a lack of ability in lesson preparation,fragmentation of questions and answers,a lack of questions that highlight the key points,anticlimax teaching process,and the habit of running over time in class[2,3].On this basis,this paper elaborates the current education state and clarifies the basic requirements of effective classroom teaching.Meanwhile,to reduce students’workload and increase the efficiency in carrying out assignments,much attention should be paid to optimizing assignment design and refining homework review and feedback.The purpose is to assign homework with an appropriate amount(achievable),precision(targeted),and suitability(personalized).Putting an end to the repetitious and unified training is not enough to improve the effect.
文摘Chinese learning in primary school is an important stage to develop students' intelligence, cultivate their comprehensive ability to use language and accumulate Chinese knowledge. Incentive education is a further requirement of our country's quality education concept for primary school Chinese education at the stage of compulsory education. Scientific incentive education can not only motivate students' learning enthusiasm, but also enable students to establish self-confidence and enhance willpower. This paper discusses the application of scientific incentive education in Chinese teaching in primary schools for reference.
文摘Reading ability is one of the most important abilities in Chinese teaching in primary school, and it is inextricably related to writing ability, oral communication ability and logical construction ability. How to combine the physical and mental development of students at the current stage to build a more efficient reading teaching mode in the actual reading teaching has become the teaching goal that primary school Chinese teachers need to explore together at this stage. In the context of the new curriculum reform, teachers need to further optimize and adjust the teaching philosophy and teaching methods of Chinese in primary schools. Relevant education departments also put forward strict requirements for reading teaching in primary schools. The primary school stage is a critical period for students to begin to develop their mind and body and consolidate their logical thinking. Therefore, teachers need to carefully guide students to deeply understand in the actual reading process, and then explore their own reading methods. Based on the reading foundation of primary school students and the importance of reading ability for primary school students, this paper explores and analyzes the teaching optimization strategies on how to effectively improve the efficiency of classroom teaching in primary school reading teaching.
文摘The mortality rate ofAcinetobacter baumannii is as high as 47%,This is inseparable From its strong resistance to carbapenems,polymyxins,aminoglycosides,quinolone antibiotics.This article will analyze the resistance of Acinetobacter baumannii to carbapenem antibiotics(meropenem and imipenem)and explore why Acinetobacter baumannii is so resistant.The data I used comes from the NCBI database,which includes six resistant groups(R)to meropenem and imipenem,and five sensitive groups(S).The level of the resistant group is complete genome,three sensitive groups are contig,and two are complete genome.Subsequently,I used Prokka in Galaxy to convert the Fasta.file into various forms such as Faa,gbk,ffn.After performing Fisher's test on all GFF files,I obtained the result chart,which includes the search for relevant domains and protein descriptions on Interpro using the chart.ProteinPlus also performed drug pocket prediction and constructed protein models using Swissmodel,as well as different multi sequence comparisons.Finally,I analyzed the functions of the proteins corresponding to the genes specific to the resistance group and the reasons for the development of drug resistance,making future research on the drug resistance of Acinetobacter baumannii easier.And further research can be conducted on the drug pocket in the protein ofAcinetobacter baumannii that has developed resistance,and drugs can be administered.
文摘Aiming at the pain points of visually impaired people during travel,this research innovatively transforms an industrial quadruped robot into a guide dog device.By transplanting the PCS-9180 motion control system(1.7 m/s,IP66),and integrating a multi-modal perception network with a lightweight YOLO11 model.Tests show that the pass-through rate in complex terrains is 98%,the response delay is 0.3 seconds,and the cost is 50%that of a guide dog.The research verifies the social value of the transformation of industrial robot technology.
文摘With the progress of information technology,the digital transformation of enterprises has developed into a key strategy to improve competitiveness.This paper studies the influence of digital transformation of enterprises on the quality of accounting information and its countermeasures,discusses how digital transformation reshapes the ability of accounting information processing,transparency,sharing,and decision support,and analyzes the challenges in technology,management,and data security during this period.Through in-depth analysis,this paper puts forward a series of targeted countermeasures,including strengthening technology and system construction,optimizing management and processes,strengthening data security and privacy protection,and promoting the improvement of laws and standards,hoping to provide practical guidance for improving the quality of accounting information in the digital transformation of enterprises.
文摘The extensive application of artificial intelligence(AI)technology is profoundly affecting the ecology of education.To analyze the advantages and disadvantages of AI for the professional growth of students,this study systematically analyzed the potential dual impacts of AI in higher education from two dimensions,namely academic ability and thinking patterns.Results indicated AI facilitated the development of students by improving learning efficiency and optimizing the integration of resources.However,it simultaneously aggravated the crisis of academic integrity and the inertia of thinking.In responding to these issues,this study proposed an integrated framework that included management,guidance,and standardization.This framework would facilitate the positive interaction between AI and education,contributing to the professional development of students.
文摘This paper systematically studies the current practical application status,existing problems and optimization suggestions of 3D printing technology in spacecraft manufacturing.Research shows that this technology has been successfully applied to the manufacturing of key components such as rocket engines and satellite structures,demonstrating advantages like lightweight and rapid prototyping.However,it still faces core challenges such as material performance,process stability,adaptability to space environments,and industrialization costs.In response to these issues,this paper proposes three optimization suggestions:enhancing manufacturing reliability by developing aerospace-specific materials,optimizing process parameters,and establishing a quality traceability system.Surface modification technology and topological optimization design are adopted to enhance the adaptability to the spatial environment,and a space-ground integrated verification method is constructed.Reduce industrialization costs through the localization of materials,modular production,and the construction of a standardized system.Research has confirmed that implementing these measures can reduce the performance dispersion of 3D-printed aerospace components by more than 50%,increase their in-orbit lifespan by three times,and lower production costs by 30-40%.The research results of this paper provide a systematic technical route and industrialization solution for the large-scale application of 3D printing technology in the aerospace field,which has significant reference value for promoting the innovation of aerospace manufacturing models.
文摘This study analyzes Agatha Christie’s mystery novel And Then There Were None from five dimensions—the nursery rhyme,Soldier Island,role of characters,death and psychological interaction—to explore its multi-dimensional metaphors and their deeper connotations.The key findings reveal that the nursery rhyme serves as a narrative thread,symbolizing both a fate-driven trial and societal rules manipulating individual destinies;Soldier Island’s isolation mirrors moral problem and emotional detachment in modern society;the characters,linked to their crimes and deaths,embody universal human flaws;death acts as both a form of justice and a critique of civilization’s fragility;the psychological struggles among the characters expose the collapse of morality under survival crises.By decoding these interconnected metaphors,the study interprets the work’s thematic framework of Sin and Punishment,offering insights into tensions between societal norms and individual existence today.
基金National Social Science Foundation of China, No. 11BJY063 Program for New Century Excellent Talents in University, No.NECT-13-0844
文摘Based on provincial panel data of water footprint and grey water footprint, and with the help of data envelopment analysis model considering and without considering the unde- sirable output, this paper estimates the water resources utilization efficiency in China from 1997 to 2011. The spatial weighting matrix based on economy-spatial distance function is established to discuss spatial autocorrelation of water resources utilization efficiency. With the help of absolute/3-convergence model, this paper concludes that there exists/%convergence in the water resources utilization efficiency. Under the conditions of considering and without considering the undesirable output, it takes about 52.6 and 5.6 years respectively to achieve the extent of half of convergence. By mean of the spatial Durbin econometric model, this paper studies spatial spillover effects of the provincial water resources utilization efficiency in China. The results are as follows. 1） With considering and without considering the undesir- able output, there is significant spatial correlation in provincial water resource efficiency in China. 2） Under the two cases, the spatial autoregressive coefficients （p） are 0.278 and 0.507 respectively, at 1% significance level. There exist the spatial spillover effects of provin- cial water resources utilization efficiency. 3） With considering the undesirable output, these factors of the education funds, the transportation infrastructure, and the industrial and agri- cultural water consumption proportion have positive impacts. These factors of foreign direct investment, the industry value-added water consumption per ten thousand yuan, per capita water consumption, and the total precipitation have negative impacts. 4） Without considering the undesirable output, the factor of GDP per laborer has a greater positive significant influ- ence on the water resources utilization efficiency. However the facts of industry value-added water consumption in ten thousand yuan and the transportation infrastructure have no sig- nificant influence. 5） Regardless of undesirable output of water resources utilization efficiency the assessment of the present real water resources utilization in China will be distorted and policy-making will be misled. The water efficiency measure considering environmental factors （such as gray water footprint） is more reasonable.
基金Supported by National Natural Science Foundation of China (Grant No.51075147)National Hi-tech Research and Development Program of China (863 Program,Grant No.2012AA041803)
文摘Wear is a major factor of disc cutters’ failure. No current theory offers a standard for the prediction of disc cutter wear yet. In the field the wear prediction method commonly used is based on the excavation length of tunnel boring machine（TBM） to predict the disc cutter wear and its wear law, considering the location number of each disc cutter on the cutterhead（radius for installation）; in theory, there is a prediction method of using arc wear coefficient. However, the preceding two methods have their own errors, with their accuracy being 40% or so and largely relying on the technicians’ experience. Therefore, radial wear coefficient, axial wear coefficient and trajectory wear coefficient are defined on the basis of the operating characteristics of TBM. With reference to the installation and characteristics of disc cutters, those coefficients are modified according to penetration, which gives rise to the presentation of comprehensive axial wear coefficient, comprehensive radial wear coefficient and comprehensive trajectory wear coefficient. Calculation and determination of wear coefficients are made with consideration of data from a segment of TBM project（excavation length 173 m）. The resulting wear coefficient values, after modification, are adopted to predict the disc cutter wear in the follow-up segment of the TBM project（excavation length of 5621 m）. The prediction results show that the disc cutter wear predicted with comprehensive radial wear coefficient and comprehensive trajectory wear coefficient are not only accurate（accuracy 16.12%） but also highly congruous, whereas there is a larger deviation in the prediction with comprehensive axial wear coefficient（accuracy 41%, which is in agreement with the prediction of disc cutters’ life in the field）. This paper puts forth a new method concerning prediction of life span and wear of TBM disc cutters as well as timing for replacing disc cutters.
基金supported by the National Natural Science Foundation for Young Scientists of China,No.81601058(to WL)Basic Research and Frontier Science Exploration Foundation of Yuzhong District,Chongqing,China,No.20180106(to FFS)
文摘Circular RNAs (circRNAs) are generated by head-to-tail splicing and are ubiquitously expressed in all multicellular organisms. Their important biological functions are increasingly recognized. Cerebral ischemia reperfusion injury-induced brain microvascular endothelial cell dysfunction is an initial stage of blood-brain barrier disruption. The expression profile and potential function of circRNAs in brain microvascular endothelial cells is unknown. Rat brain microvascular endothelial cells were extracted and cultured in glucose-free medium for 4 hours with 5% CO2 and 95% N2, and the medium was then replaced with complete growth medium for 6 hours. The RNA in these cells was then extracted. The circRNA was identified by Find_circ and CIRI2 software. Functional and pathway enrichment analysis of genes that were common to differentially expressed mRNAs and circRNA host genes was performed by the Database for Annotation, Visualization and Integrated Discovery Functional Annotation Tool. Miranda software was used to predict microRNAs that were potentially sponged by circRNAs. Furthermore, cytoscape depicted the circR-NA-microRNA interaction network. The results showed that there were 1288 circRNAs in normal and oxygen-glucose deprived/recovered primary brain microvascular endothelial cells. There are 211 upregulated and 326 downregulated differentially expressed circRNAs. The host genes of these differentially expressed circRNAs overlapped with those of differentially expressed mRNAs. The shared genes were further studied by functional enrichment analyses, which revealed that circRNAs may contribute to calcium ion function and the cyclic guanosine 3′,5′-monophosphate (CAMP) dependent protein kinase (PKα) signaling pathway. Next, quantitative reverse transcription polymerase chain reaction assays were performed to detect circRNA levels transcribed from the overlapping host genes. Eight out of the ten circRNAs with the highest fold-change identified by sequencing were successfully verified. Subsequently, the circRNA-microRNA interaction networks of these eight circRNAs were explored by bioinformatic analysis. These results demonstrate that altered circRNAs may be important in the pathogenesis of cerebral ischemia reperfusion injury and consequently may also be potential therapeutic targets for cerebral ischemia diseases. All animal experiments were approved by the Chongqing Medical University Committee on Animal Research, China (approval No. CQMU20180086) on March 22, 2018.
基金supported by the National Science and Technology Major Project for Water Pollution Control and Treatment (Grant No. 2017ZX07101001)National Natural Science Foundation of China (Grant NO.41671529)+2 种基金the Hundred Young Talents Program of the Institute of Mountain Hazards and Environment (Grant No. SDSQB-2015-01)the Monitoring and Warning Program for Resources and Environment Carrying Capability in Sichuan Province (Grant No. ZXGH201709)the Program for Resource and Environment Carrying Capability in Jiu ZhaiG ou Earthquake Disaster Area (Grant No. Y7K2190190)
文摘An earthquake in the Jiuzhaigou area caused numerous secondary disasters, such as rolling stones, land collapse, landslides and debris flow, which badly affected the safety of human settlements and influenced the spatial layout of the post-disaster reconstruction. Therefore, carrying out assessments of land and identifying a suitable zone for human habitats were very important. This research creates the territorial suitability assessment and function zoning conceptual model in the earthquake-stricken area, and the new methods of the territorial suitability evaluation system were used to divide the spatial functional zones of the earthquake stricken area, which provide a theoretical guidance and decisionmaking basis for the reconstruction of the disaster area. The results showed that:(1) The Jiuzhaigou earthquake-stricken area comprises of an ecological area that has a high level of importance to the ecosystem. In the earthquake-stricken area, 65% of national land is at an altitude of 3000-4000 m, and therefore not suitable for a high level of intensive reconstruction, but reconstructed in an eco-friendly manner.(2) The zone suitable for reconstruction comprises mainly of the river valley and the flat terrain of western parts. The land with low suitability is mainly located on steep terrain, such as highmountains and low gullies. The geographic and geomorphic conditions limit the spread of a suitable reconstruction zone.(3) The earthquake-stricken area mainly comprises of a tourism industry gathering area, population gathering area, agriculture and animal husbandry development area, and ecological preservation area with areas of 76 km^2, 44 km^2, 1591 km^2 and 7512 km^2, respectively. Scientifically zoning the reconstruction areas using scientific evaluation may provide guidance for the location of reconstruction sites.
文摘AIM:To understand the complex reaction of gastric inflammation induced by Helicobacter pylori(H pylori) in a systematic manner using a protein interaction network. METHODS:The expression of genes significantly changed on microarray during H pylori infection was scanned from the web literary database and translated into proteins.A network of protein interactions was constructed by searching the primary interactions of selected proteins.The constructed network was mathematically analyzed and its biological function was examined.In addition,the nodes on the network were checked to determine if they had any further functional importance or relation to other proteins by extending them. RESULTS:The scale-free network showing the relationship between inflammation and carcinogenesis was constructed.Mathematical analysis showed hub and bottleneck proteins,and these proteins were mostly related to immune response.The network contained pathways and proteins related to H pylori infection,such as the JAK-STAT pathway triggered by interleukins.Activation of nuclear factor (NF)-κB,TLR4,and other proteins known to function as core proteins of immune response were also found. These immune-related proteins interacted on the network with pathways and proteins related to the cell cycle,cell maintenance and proliferation,andtranscription regulators such as BRCA1,FOS,REL,and zinc finger proteins.The extension of nodes showed interactions of the immune proteins with cancer- related proteins.One extended network,the core network,a summarized form of the extended network, and cell pathway model were constructed. CONCLUSION:Immune-related proteins activated by H pylori infection interact with proto-oncogene proteins.The hub and bottleneck proteins are potential drug targets for gastric inflammation and cancer.
基金supported by the Key Technoligies R&D Program of China during the 12th Five-Year Plan period (2012BAJ24B06)the National Natural Science Foundation of China (41230855)
文摘Two variable charge soils were incubated with biochars derived from straws of peanut, soybean, canola, and rice to investigate the effect of the biochars on their chemical properties and Pb（II） adsorption using batch experiments. The results showed soil cation exchange capacity （CEC） and pH significantly increased after 30 d of incubation with the biochars added. The incorporation of the biochars markedly increased the adsorption of Pb（II）, and both the electrostatic and non-electrostatic adsorption mechanisms contributed to Pb（II） adsorption by the variable charge soils. Adsorption isotherms illustrated legume- straw derived biochars more greatly increased Pb（II） adsorption on soils through the non-electrostatic mechanism via the formation of surface complexes between Pb（II） and acid functional groups of the biochars than did non-legume straw biochars. The adsorption capacity of Pb（II） increased, while the desorption amount slightly decreased with the increasing suspension pH for the studied soils, especially in a high suspension pH, indicating that precipitation also plays an important role in immobilizing Pb（II） to the soils.
基金Project supported by the National Key R&D Program of China(2017YFA0205100)the National Natural Science Foundation of china(2193700321874027)。
文摘High-sensitivity detection of porphyrin in blood is very important for the early diagnosis and treatment of porphyria.Based on the advantages of longer luminescence lifetime and lower background interference,organic afterglow molecular porphyrin detection probes were developed,but these probes show poor water solubility and insufficient luminescence intensity.Herein,we present an afterglow nanoprobe(Eu-NP)for porphyria detection in whole blood.The luminescent substance(europium complex)and the organic vinyl co mpound reacted with singlet oxygen(^(1)O_(2))were selected for encapsulation in polystyrene spheres.Eu-NP can respond to^(1)O_(2)produced by porphyrins,and the detection signals can be obtained by the emission of the afterglow Eu^(3+)-emissive nanosensor.Eu-NP can achieve high-sensitivity detection of porphyrin,and the lowest detection limit reaches 0.29μmol/L.The porphyrin detection in whole blood samples is consistent with clinical diagnosis results.Compared with the organic afterglow molecule,the Eu-NPs constructed in this work show a higher signal-to-noise ratio and sensitivity of porphyria detection.
基金supported by Hangzhou Scientific and Technological Program(20170432B03)the National Key Technology Research and Development Program(2015BAD01B02)the National Natural Science Foundation of China(31661143006).
文摘Melatonin(MLT)is a hormonal substance found in many organisms and can improve plant stress resistance.In this study,the japonica rice variety Y32 and indica rice variety NJ6 were cultivated in hydroponics under different concentrations of CdCl2 at the two-leaf stage.The growth,physiological and biochemical responses of the seedlings and the expression of cadmium(Cd)-related genes under exogenous melatonin(MLT)treatment were assessed.The results indicated that Cd stress destroyed the dynamic balance between reactive oxygen species(ROS)production and removal,resulting in ROS accumulation,membrane lipid peroxidation,and impaired growth and development.Following the application of exogenous MLT to rice seedlings,increases in plant biomass including both underground and above-ground areas were observed.MLT also scavenged the inhibition of superoxide dismutase(SOD)and peroxidase(POD)in a concentration dependent manner in response to Cd stress.Catalase(CAT)activity and malondialdehyde(MDA)expression also decreased following MLT treatment.Amongst the six Cd-related genes assessed,five genes were downregulated and one was up-regulated in response to MLT treatment.Taken together,these data demonstrate that MLT improves the resilience of rice seedlings at the biochemical,physiological,and molecular levels,and diminishes the damage caused by Cd stress.
