The high-temperature dissolution behavior of primary carbides in samples taken from GCr15 continuous-casting bloom was observed in-situ by confocal laser scanning microscopy.Equations were fitted to the dissolution ki...The high-temperature dissolution behavior of primary carbides in samples taken from GCr15 continuous-casting bloom was observed in-situ by confocal laser scanning microscopy.Equations were fitted to the dissolution kinetics of primary carbides during either heating or soaking.Dissolution of carbides proceeded in three stages(fast→slow→faster)as either temperature or holding time was increased.During the heating process and during the first and third stages of the soaking process,the original size of the carbides determined the steepness of the slope,but during the middle(“slow”)stage of the soaking process,the slope remained zero.The initial size of the carbides varied greatly,but their final dissolution temperature fell within the narrow range of 1210-1235℃,and the holding time remained within 50 min.Fractal analysis was used to study the morphological characteristics of small and medium-sized carbides during the dissolution process.According to changes in the fractal dimension before and after soaking,the carbides tended to evolve towards a more regular morphology.展开更多
In this article,we comment on the article by Peta et al.This study evaluates the diagnostic performance of FibroTest-Actitest,transient elastography,and the fibrosis-4 index against a histological reference.Using the ...In this article,we comment on the article by Peta et al.This study evaluates the diagnostic performance of FibroTest-Actitest,transient elastography,and the fibrosis-4 index against a histological reference.Using the Obuchowski measure,the authors demonstrate that FibroTest and vibration-controlled transient elastography outperform the fibrosis-4 index in detecting fibrosis.Additionally,Actitest offers superior estimation of inflammatory activity compared to conventional biomarkers.Assessing liver fibrosis is crucial for managing autoimmune hepatitis(AIH),yet reliance on invasive liver biopsy remains higher than in other liver diseases.This is partly due to more complex diagnostic criteria for AIH,the lack of standardized scoring for non-invasive testing,and the presence of inflammation,which can lead to falsely elevated results with non-invasive tests.A Bayesian latent class model further supports the reliability of these non-invasive tests,highlighting their potential to complement biopsy,particularly for longterm disease monitoring.These findings underscore the importance of noninvasive diagnostics in optimizing AIH management.展开更多
In this editorial,we comment on the article by Rolim et al in World Journal of Hepatology,which highlights the impacts of hepatopulmonary syndrome(HPS)related to schistosomiasis in patients with and without cirrhosis....In this editorial,we comment on the article by Rolim et al in World Journal of Hepatology,which highlights the impacts of hepatopulmonary syndrome(HPS)related to schistosomiasis in patients with and without cirrhosis.Schistosomiasis,a parasitic disease affecting millions worldwide,frequently leads to portal hypertension.Its outcomes are more devastating in cirrhosis than in non-cirrhotic portal hypertension,due to the complex interplay between cirrhosis and HPS,a severe pulmonary vascular complication.Cirrhosis distorts hepatic architecture,impairs portal blood flow,and triggers systemic vascular changes.Schistosomiasis exacerbates portal hypertension and inflammation,further injuring the liver.In non-cirrhotic portal hypertension,significant vascular resistance occurs,but preserved liver function mitigates systemic effects.In contrast,cirrhosis amplifies hypoxia,worsens pulmonary shunting,and predisposes patients to respiratory failure,infection,and death.In a retrospective study of 113 patients,Rolim et al found that cirrhosis had an impact on mortality,yet the presence of HPS did not significantly affect survival.While cirrhosis worsening outcomes are anticipated,HPS should theoretically worsen survival by impairing oxygenation.Early diagnosis,parasite control,and managing cirrhosis-related complications are critical for schistosomiasis-related liver disease.Understanding these differences underscores the importance of integrating liver health into global schistosomiasis management strategies.展开更多
Food contaminants,particularly insecticides,are important factors contributing to obesity and other adverse effects.As the most widely used diamide insecticide worldwide,chlorantraniliprole(CP)is ubiquitous in food an...Food contaminants,particularly insecticides,are important factors contributing to obesity and other adverse effects.As the most widely used diamide insecticide worldwide,chlorantraniliprole(CP)is ubiquitous in food and the environment.However,the influence of CP on obesity and the gut microbiota remains unknown.In this study,we administered CP/carboxymethyl cellulose sodium to C57BL/6J mice with a high-fat diet(HFD)via gavage for 13 weeks.The CP exposure induced significant increases in body weight gain,fat mass,serum total cholesterol(TC),and low-density lipoprotein cholesterol(LDL-C).Moreover,CP aggravated the imbalance in the gut microbiota by increasing the relative abundance of obesity-associated bacteria and reducing the relative abundance of beneficial bacteria.Based on untargeted metabolomics analysis,CP was found to be involved in the regulation of pathways including Alanine,aspartate and glutamate metabolism and Arginine and proline metabolism.Notably,CP exposure primarily induced alterations in microbial metabolites within these pathways,such as L-(+)-aspartic acid and L-glutamic acid.Additionally,individual metabolites,such as the lipid mediator(oleoyl ethanolamide),also demonstrated alterations upon CP exposure.Furthermore,Spearman correlation analysis revealed several noteworthy associations between microbial alterations,metabolite changes,and phenotypes.The results of the study demonstrate a connection between microbiota,metabolites,and the effects of CP exposure on HFD-induced obesity,elucidating the critical role of the gut microbiota and its metabolites in the toxic effects of CP.展开更多
BACKGROUND Colorectal cancer(CRC)is the second leading cause of cancer-related deaths worldwide with an alarming rise in early-onset CRC(eoCRC)over the past several decades.Unlike late-onset CRC,the drivers behind eoC...BACKGROUND Colorectal cancer(CRC)is the second leading cause of cancer-related deaths worldwide with an alarming rise in early-onset CRC(eoCRC)over the past several decades.Unlike late-onset CRC,the drivers behind eoCRC remain less clear.While certain risk factors such as obesity and smoking have demonstrated a relatively strong association with eoCRC in the literature,some studies have challenged these associations,emphasizing the need for additional studies.METHODS This cross-sectional study used de-identified data from the National Health and Nutrition Examination Survey(1999-2023),including 30321 United States adults aged 18 to 49 years.Participants with missing key variables were excluded.Standardized protocols were used to collect demographic,lifestyle,anthropo-metric[body mass index(BMI),body roundness index(BRI),waist circumference(WC)],and self-reported CRC data.Logistic regression and propensity score matching assessed associations between obesity-related parameters and eoCRC.Statistical analyses were performed in R and Stata,with P<0.05 defined as significant.RESULTS Of 30321 participants,48 received a diagnosis of eoCRC.Patients with eoCRC were older(mean age 39.96 years vs 34.36 years;P<0.001)and had higher WC and BRI.None of the eoCRC patients were heavy drinkers(P=0.006).Unadjusted models demonstrated significant associations of eoCRC with BRI quartiles,as well as BMI-defined obesity,WC,and smoking.In unadjusted models,BRI remained the strongest independent predictor;those in the highest BRI quartiles had over 10-fold greater odds of eoCRC.In fully adjusted models,BRI remained significant,but BMI-and waist-based obesity were not.CONCLUSION BRI is a stronger predictor of eoCRC risk compared to other obesity indices and is a superior tool for identifying young individuals at higher risk of CRC.展开更多
Primary biliary cholangitis(PBC)is a chronic autoimmune cholestatic liver disease characterized by progressive bile duct destruction,leading to fibrosis,cirrhosis,and eventual liver failure.Over the past two decades,s...Primary biliary cholangitis(PBC)is a chronic autoimmune cholestatic liver disease characterized by progressive bile duct destruction,leading to fibrosis,cirrhosis,and eventual liver failure.Over the past two decades,significant advancements have paved the way for novel therapeutic strategies.Ursodeoxycholic acid(UDCA)has been the cornerstone of PBC management,improving survival and delaying disease progression in most patients.However,up to 40%of patients demonstrate an inadequate response to UDCA,necessitating additional treatment options.Obeticholic acid(OCA),a farnesoid X receptor agonist,has emerged as a second-line therapy,showing efficacy in reducing alkaline phosphatase levels and improving liver biochemistry.Beyond UDCA and OCA,a new wave of therapeutic agents are reshaping the PBC landscape.These include fibrates,peroxisome proliferator-activated receptor agonists and novel immunomodulatory drugs aimed at reducing autoimmune-mediated liver injury.Bile acid transport inhibitors,anti-fibrotic agents,and gut microbiome-targeted therapies are also under investigation,offering hope for personalized treatment approaches.This review highlights the evolution of PBC therapy,emphasizing the unmet needs of patients with refractory disease and the potential of emerging therapies to improve outcomes.As the therapeutic landscape continues to expand,optimizing treatment strategies through precision medicine holds the promise of transforming the management of PBC.展开更多
Two CoⅡ-based complexes,{[Co(dps)_(2)(N_(3))_(2)]·H_(2)O}_n(1)and[Co(dps)_(2)(N_(3))_(2)]_n(2),show a 1D chain and a 3D network,respectively.The central CoⅡions in the complexes have the same coordination envir...Two CoⅡ-based complexes,{[Co(dps)_(2)(N_(3))_(2)]·H_(2)O}_n(1)and[Co(dps)_(2)(N_(3))_(2)]_n(2),show a 1D chain and a 3D network,respectively.The central CoⅡions in the complexes have the same coordination environment with the[Co(dps)_(4)(N_(3))_(2)]unit.Although the differences in crystal parameters are nearly negligible,their magnetic properties are very different.AC susceptibility data show that 1 behaves as a typical field-induced single-ion magnet(SIM)with the out-of-phase(χ_(M)”)signals,while 2 shows ac signals ofχ_(M)”without peaks even under applied dc filed within our measurement window.Far-IR magneto-spectra(FIRMS)show strong spin-phonon couplings at 0 T in 2,likely making the magnetic relaxation in 2 fast,while the couplings are negligible in 1.Small spin-phonon coupling in 1 likely leads to slower magnetic relaxation,making 1 a SIM.The difference in the properties is due to the structural rigidity of 2 in its 3D network,leading to stronger spin-phonon coupling.Combined high-field EPR(HF-EPR)and FIRMS studies give spin-Hamiltonian parameters,including D=64.0(9)cm^(-1),|E|=15.7(2)cm^(-1)for 1 and D=80.0(2)cm^(-1),|E|=19.0(1)cm^(-1)for 2.展开更多
This editorial comment is on the article by Xu et al.It offers an in-depth analysis of liver function assessment tools and their prognostic roles in non-malignant liver diseases,with a focus on the albumin-bilirubin(A...This editorial comment is on the article by Xu et al.It offers an in-depth analysis of liver function assessment tools and their prognostic roles in non-malignant liver diseases,with a focus on the albumin-bilirubin(ALBI)score.ALBI’s components,grading system,and clinical relevance across various liver conditions are reviewed and compared with traditional models such as the Child-Pugh and model for end-stage liver disease scores.We included recent studies evaluating ALBI’s role in estimating liver function,suggesting it may help differentiate patients who appear similar under other staging systems,and assist in guiding clinical decisions.Although ALBI is primarily used as an indicator of hepatic reservoir in hepatocellular carcinoma,it has been demonstrated a positive correlation with overall survival,tumor recurrence,and post-hepatectomy liver failure in patients undergoing potentially curative treatments such as liver resection,liver transplantation,and local ablation.Moreover,several studies suggest that ALBI can also predict survival outcomes,treatment-related toxicity,and liver-related complications in patients receiving trans-arterial chemoembolization,radioembolization,external-beam radiotherapy,or systemic therapies.Its growing use in nonmalignant liver diseases,including primary biliary cholangitis,cirrhosis,acute and chronic liver failure,and viral hepatitis highlights the need for large,prospective studies.Further studies are warranted to validate the integration of ALBI into routine clinical practice and to clarify its role in guiding prognosis and treatment planning.展开更多
The identification of novel biomarkers for early prostate cancer diagnosis is highly important because early detection and treatment are critical for the medical management of patients. Disruption in the continuity of...The identification of novel biomarkers for early prostate cancer diagnosis is highly important because early detection and treatment are critical for the medical management of patients. Disruption in the continuity of both the basal cell layer and basement membrane is essential for the progression of high-grade prostatic intraepithelial neoplasia （HGPIN） to invasive adenocarcinoma in human prostate. The molecules involved in the conversion to an invasive phenotype are the subject of intense scrutiny. We have previously reported that matrix metalloproteinase-26 （MMP-26） promotes the invasion of human prostate cancer cells via the cleavage of basement membrane proteins and by activating the zymogen form of MMP-9. Furthermore, we have found that tissue inhibitor of metalloproteinases-4 （TIMP-4） is the most potent endogenous inhibitor of MMP-26. Here we demonstrate higher （p〈0.0001） MMP-26 and TIMP-4 expression in HGPIN and cancer, compared to non-neoplastic acini. Their expression levels are highest in HGPIN, but decline in invasive cancer （p〈0.001 for each） in the same tissues. Immunohistochemical staining of serial prostate cancer tissue sections suggests colocalization of MMP-26 and TIMP-4. The present study indicates that MMP-26 and TIMP-4 may play an integral role during the conversion of HGPIN to invasive cancer and may also serve as markers for early prostate cancer diagnosis.展开更多
State-supported programs providing loans and scholarships in exchange for service in under-served areas provide an important source of financial support for medical students while encouraging them to select careers in...State-supported programs providing loans and scholarships in exchange for service in under-served areas provide an important source of financial support for medical students while encouraging them to select careers in primary care. The purpose of this research was to seek a better understanding of these often unheralded but important state sources of support, and learn if they have continued to grow in the twenty-first century. Administrative data were obtained on state-supported programs operating in 2008 that provided financial support to students, resident or practicing physicians, physician assistants, nurse practitioners, certified nurse midwives, dentists, and licensed mental healthcare providers in exchange for service in an underserved area. The authors identified numbers, types of state-supported programs, program workforce strength, and features of state programs. In 2008, 75 state programs, operating in 37 states, collectively had 5113 program participants under contract. Loan repayment programs (n = 42, 56%) were the most common type of state-supported programs. Practitioners signed initial contracts in 2008 totaled 1173, with more non-physicians (n = 681, 58%) signing initial contracts than physicians (n = 492, 42%). Additionally, 2803 practitioners were serving in programs in 2008. Field placement was also slightly greater among non-physicians in 2008 (n = 1433, 51%) than physicians (n = 1370, 49%). State support-for-service programs remains an important source of financial assistance for those willing to make service commitments in underserved areas. Moreover, these programs continue to increase in size, even amidst the economic malaise, and provide an obligated primary care workforce in underserved areas.展开更多
Water plays an important role in many essential biological processes of membrane proteins in hydrated lipid environments.In general,the 1H polarization transfers berween water molecules and site--specific protons in p...Water plays an important role in many essential biological processes of membrane proteins in hydrated lipid environments.In general,the 1H polarization transfers berween water molecules and site--specific protons in proteins can be classified as coherent(via dipolar spin diffusion)and incoherent(via chemical exchange and nuclear Overhauser effect)transfers.Solid-state NMR is the technique of choice for studying such water-protein interactions in membrane-bound proteins/peptides through the detection of'H polarization transfers from water to the proteins.These polarization transfer mechanisms often exist simultaneously and are difficult to quantify individually.Here,we review water-protein polarization transfer techniques in solid state NMR with a focus on the recent progress for the direct detection of site-specific kinetic water-protein chemical exchange processes on the sub-millisecond time scale in membrane-bound proteins.The measurements of the pure chemical exchange ki-netics provide a unique opportunity to understand the role that water plays in the structure-function relationships of membrane bound species at the water-bilayer interface.In addi-tion,the perspective of chemical exchange saturation transfer(CEST)experiments in membrane-bound proteins/peptides is further discussed.展开更多
Dear Editor,This letter is concerned with the role of recurrent neural networks(RNNs)on the controller design for a class of nonlinear systems.Inspired by the architectures of RNNs,the system states are stacked accord...Dear Editor,This letter is concerned with the role of recurrent neural networks(RNNs)on the controller design for a class of nonlinear systems.Inspired by the architectures of RNNs,the system states are stacked according to the dynamic along with time while the controller is represented as the neural network output.To build the bridge between RNNs and finite-time controller,a novel activation function is imposed on RNNs to drive the convergence of states at finite-time and propel the overall control process smoother.Rigorous stability proof is briefly provided for the convergence of the proposed finite-time controller.At last,a numerical simulation example is presented to illustrate the efficiency of the proposed strategy.Neural networks can be classified as static(feedforward)and dynamic(recurrent)nets[1].The former nets do not perform well in dealing with training data and using any information of the local data structure[2].In contrast to the feedforward neural networks,RNNs are constituted by high dimensional hidden states with dynamics.展开更多
An improved algorithm for computing multiphase flows is presented in which the multimaterial Moment-of-Fluid(MOF)algorithm for multiphase flows,initially described by Li et al.(2015),is enhanced addressing existing MO...An improved algorithm for computing multiphase flows is presented in which the multimaterial Moment-of-Fluid(MOF)algorithm for multiphase flows,initially described by Li et al.(2015),is enhanced addressing existing MOF difficulties in computing solutions to problems in which surface tension forces are crucial for understanding salient flow mechanisms.The Continuous MOF(CMOF)method is motivated in this article.The CMOF reconstruction method inherently removes the"checkerboard instability"that persists when using the MOF method on surface tension driven multiphase(multimaterial)flows.The CMOF reconstruction algorithm is accelerated by coupling the CMOF method to the level set method and coupling the CMOF method to a decision tree machine learning(ML)algorithm.Multiphase flow examples are shown in the two-dimensional(2D),three-dimensional(3D)axisymmetric"RZ",and 3D coordinate systems.Examples include two material and three material multiphase flows:bubble formation,the impingement of a liquid jet on a gas bubble in a cryogenic fuel tank,freezing,and liquid lens dynamics.展开更多
This study assesses the capability of a coarse-resolution ocean model to replicate the response of the Southern Ocean Meridional Overturning Circulation(MOC) to intensified westerlies,focusing on the role of the eddy ...This study assesses the capability of a coarse-resolution ocean model to replicate the response of the Southern Ocean Meridional Overturning Circulation(MOC) to intensified westerlies,focusing on the role of the eddy transfer coefficient(κ).κ is a parameter commonly used to represent the velocities induced by unresolved eddies.Our findings reveal that a stratification-dependent κ,incorporating spatiotemporal variability,leads to the most robust eddy-induced MOC response,capturing 82% of the reference eddy-resolving simulation.Decomposing the eddy-induced velocity into its vertical variation(VV) and spatial structure(SS) components unveils that the enhanced eddy compensation response primarily stems from an augmented SS term,while the introduced VV term weakens the response.Furthermore,the temporal variability of the stratification-dependent κ emerges as a key factor in enhancing the eddy compensation response to intensified westerlies.The experiment with stratification-dependent κ exhibits a more potent eddy compensation response compared to the constant κ,attributed to the structure of κ and the vertical variation of the density slope.These results underscore the critical role of accurately representing κ in capturing the response of the Southern Ocean MOC and emphasize the significance of the isopycnal slope in modulating the eddy compensation mechanism.展开更多
In a time characterized by the availability of vast amounts of data,the effective utilization of information is critical for timely decision-making in military operations.However,processing large amounts of data requi...In a time characterized by the availability of vast amounts of data,the effective utilization of information is critical for timely decision-making in military operations.However,processing large amounts of data requires computational resources and time.Therefore,decision makers have used data-centric technologies to take advantage of public and private data sources to support military operations.This survey explores the integration and application of data-centric technologies,such as data analytics,data science,and machine learning,to optimize decision-making workflows within military contexts supporting the deployment of military assets and resources.To address the information gap,this article presents a literature review,specifically a survey.Our survey examines the use of the mentioned technologies to process and analyze information that contributes to the phases of situational awareness,and planning in military environments.We then introduce a taxonomy of the approaches associated with implementing these technologies in military scenarios.Furthermore,we discuss relevant factors for the seamless integration of data-centric technologies into military decision-making processes,and reveal the importance of specialized personnel,architectures,and cybersecurity issues in the task of developing prototypes and models.The findings of this paper aim to provide valuable insights for military institutions,offering a deeper understanding of the use of data-centric technologies as innovative practices to enhance the effectiveness of military decision-making.展开更多
Intensive care unit-acquired weakness(ICU-AW)is a prevalent issue in critical care,leading to significant muscle atrophy and functional impairment.Aiming to address this,Neuromuscular Electrical Stimulation(NMES)has b...Intensive care unit-acquired weakness(ICU-AW)is a prevalent issue in critical care,leading to significant muscle atrophy and functional impairment.Aiming to address this,Neuromuscular Electrical Stimulation(NMES)has been explored as a therapy.This systematic review assesses NMES's safety and effectiveness in enhancing functional capacity and mobility in pre-and post-cardiac surgery patients.NMES was generally safe and feasible,with intervention sessions varying in frequency and duration.Improvements in muscle strength and 6-minute walking test distances were observed,particularly in preoperative settings,but postoperative benefits were inconsistent.NMES showed promise in preventing muscle loss and improving strength,although its impact on overall functional capacity remained uncertain.Challenges such as short ICU stays and body composition affecting NMES efficacy were noted.NMES also holds potential for other conditions like cerebral palsy and stroke.Further research is needed to optimize NMES protocols and better understand its full benefits in preventing ICU-AW and improving patient outcomes.展开更多
In this study,we put forward a radiative-convective-transportive energy balance model of a gray atmosphere to examine individual roles of the greenhouse effect of water vapor,vertical convection,and atmospheric polewa...In this study,we put forward a radiative-convective-transportive energy balance model of a gray atmosphere to examine individual roles of the greenhouse effect of water vapor,vertical convection,and atmospheric poleward energy transport as well as their combined effects for a quasi-linear relationship between the outgoing longwave radiation(OLR)and surface temperature(T_(S)).The greenhouse effect of water vapor enhances the meridional gradient of surface temperature,thereby directly contributing to a quasi-linear OLR-T_(S) relationship.The atmospheric poleward energy transport decreases the meridional gradient of surface temperature.As a result of the poleward energy transport,tropical(high-latitude)atmosphere-surface columns emit less(more)OLR than the solar energy input at their respective locations,causing a substantial reduction of the meridional gradient of the OLR.The combined effect of reducing the meridional gradients of both OLR and surface temperature by the poleward energy transport also contributes to the quasi-linear OLR-T_(S) relationship.Vertical convective energy transport reduces the meridional gradient of surface temperature without affecting the meridional gradient of OLR,thereby suppressing part of the reduction to the increasing rate of OLR with surface temperature by the greenhouse effect of water vapor and poleward energy transport.Because of the nature of the energy balance in the climate system,such a quasi-linear relationship is also a good approximation for the relationship between the annual-mean net downward solar energy flux at the top of the atmosphere and surface temperature.展开更多
In pursuit of higher energy density,lower cost,longer lifespan and safety,remarkable research efforts have been taken to innovate various types of energy storage materials/devices,especially metal-ion batteries such a...In pursuit of higher energy density,lower cost,longer lifespan and safety,remarkable research efforts have been taken to innovate various types of energy storage materials/devices,especially metal-ion batteries such as Li-ion batteries(LIBs).One of the major challenges is to elucidate the working mechanisms and/or the controlling factors of any new material in a full battery,which requires adequate characterization/diagnosis techniques.Among the numerous electrochemical ex-situ and insitu characterization techniques,magnetic resonance techniques,including nuclear magnetic resonance(NMR),magnetic resonance imaging(MRI)and electron paramagnetic resonance(EPR),are unique in terms of providing structural information at the atomic level and real-time phase and morphology evolution and characterizing ionic motion at various timescales.This special issue is dedicated to an editorial and a selection of papers on the theme of investigating energy storage materials/devices using magnetic resonance techniques.As the vip editors of this special issue,we are honored to introduce the following high-quality research articles and review articles.展开更多
For designing low-impedance magnetic tunnel junctions(MTJs),it has been found that tunneling magnetoresistance strongly correlates with the insulating barrier thickness,imposing a fundamental problem about the relatio...For designing low-impedance magnetic tunnel junctions(MTJs),it has been found that tunneling magnetoresistance strongly correlates with the insulating barrier thickness,imposing a fundamental problem about the relationship between spin polarization of ferromagnet and the insulating barrier thickness in MTJs.Here,we investigate the influence of alumina barrier thickness on tunneling spin polarization(TSP)through a combination of theoretical calculations and experimental verification.Our simulating results reveal a significant impact of barrier thickness on TSP,exhibiting an oscillating decay of TSP with the barrier layer thinning.Experimental verification is realized on FeNi/AlO_(x)/Al superconducting tunnel junctions to directly probe the spin polarization of FeNi ferromagnet using Zeeman-split tunneling spectroscopy technique.These findings provide valuable insights for designs of high-performance spintronic devices,particularly in applications such as magnetic random access memories,where precise control over the insulating barrier layer is crucial.展开更多
基金supported by Independent Research Project of State Key Laboratory of Advanced Special Steel,Shanghai Key Laboratory of Advanced Ferrometallurgy,Shanghai University(SKLASS-2023-Z13)the Science and Technology Commission of Shanghai Municipality(No.19DZ2270200)+1 种基金A portion of the work was performed at US National High Magnetic Field Laboratory,which is supported by the National Science Foundation(Cooperative Agreement No.DMR-1157490 and DMR-1644779)the State of Florida.Thanks also to Mary Tyler for editing.
文摘The high-temperature dissolution behavior of primary carbides in samples taken from GCr15 continuous-casting bloom was observed in-situ by confocal laser scanning microscopy.Equations were fitted to the dissolution kinetics of primary carbides during either heating or soaking.Dissolution of carbides proceeded in three stages(fast→slow→faster)as either temperature or holding time was increased.During the heating process and during the first and third stages of the soaking process,the original size of the carbides determined the steepness of the slope,but during the middle(“slow”)stage of the soaking process,the slope remained zero.The initial size of the carbides varied greatly,but their final dissolution temperature fell within the narrow range of 1210-1235℃,and the holding time remained within 50 min.Fractal analysis was used to study the morphological characteristics of small and medium-sized carbides during the dissolution process.According to changes in the fractal dimension before and after soaking,the carbides tended to evolve towards a more regular morphology.
文摘In this article,we comment on the article by Peta et al.This study evaluates the diagnostic performance of FibroTest-Actitest,transient elastography,and the fibrosis-4 index against a histological reference.Using the Obuchowski measure,the authors demonstrate that FibroTest and vibration-controlled transient elastography outperform the fibrosis-4 index in detecting fibrosis.Additionally,Actitest offers superior estimation of inflammatory activity compared to conventional biomarkers.Assessing liver fibrosis is crucial for managing autoimmune hepatitis(AIH),yet reliance on invasive liver biopsy remains higher than in other liver diseases.This is partly due to more complex diagnostic criteria for AIH,the lack of standardized scoring for non-invasive testing,and the presence of inflammation,which can lead to falsely elevated results with non-invasive tests.A Bayesian latent class model further supports the reliability of these non-invasive tests,highlighting their potential to complement biopsy,particularly for longterm disease monitoring.These findings underscore the importance of noninvasive diagnostics in optimizing AIH management.
文摘In this editorial,we comment on the article by Rolim et al in World Journal of Hepatology,which highlights the impacts of hepatopulmonary syndrome(HPS)related to schistosomiasis in patients with and without cirrhosis.Schistosomiasis,a parasitic disease affecting millions worldwide,frequently leads to portal hypertension.Its outcomes are more devastating in cirrhosis than in non-cirrhotic portal hypertension,due to the complex interplay between cirrhosis and HPS,a severe pulmonary vascular complication.Cirrhosis distorts hepatic architecture,impairs portal blood flow,and triggers systemic vascular changes.Schistosomiasis exacerbates portal hypertension and inflammation,further injuring the liver.In non-cirrhotic portal hypertension,significant vascular resistance occurs,but preserved liver function mitigates systemic effects.In contrast,cirrhosis amplifies hypoxia,worsens pulmonary shunting,and predisposes patients to respiratory failure,infection,and death.In a retrospective study of 113 patients,Rolim et al found that cirrhosis had an impact on mortality,yet the presence of HPS did not significantly affect survival.While cirrhosis worsening outcomes are anticipated,HPS should theoretically worsen survival by impairing oxygenation.Early diagnosis,parasite control,and managing cirrhosis-related complications are critical for schistosomiasis-related liver disease.Understanding these differences underscores the importance of integrating liver health into global schistosomiasis management strategies.
基金supported by national natural science foundation of China(32001794)awarded to Dr.Ye Peng。
文摘Food contaminants,particularly insecticides,are important factors contributing to obesity and other adverse effects.As the most widely used diamide insecticide worldwide,chlorantraniliprole(CP)is ubiquitous in food and the environment.However,the influence of CP on obesity and the gut microbiota remains unknown.In this study,we administered CP/carboxymethyl cellulose sodium to C57BL/6J mice with a high-fat diet(HFD)via gavage for 13 weeks.The CP exposure induced significant increases in body weight gain,fat mass,serum total cholesterol(TC),and low-density lipoprotein cholesterol(LDL-C).Moreover,CP aggravated the imbalance in the gut microbiota by increasing the relative abundance of obesity-associated bacteria and reducing the relative abundance of beneficial bacteria.Based on untargeted metabolomics analysis,CP was found to be involved in the regulation of pathways including Alanine,aspartate and glutamate metabolism and Arginine and proline metabolism.Notably,CP exposure primarily induced alterations in microbial metabolites within these pathways,such as L-(+)-aspartic acid and L-glutamic acid.Additionally,individual metabolites,such as the lipid mediator(oleoyl ethanolamide),also demonstrated alterations upon CP exposure.Furthermore,Spearman correlation analysis revealed several noteworthy associations between microbial alterations,metabolite changes,and phenotypes.The results of the study demonstrate a connection between microbiota,metabolites,and the effects of CP exposure on HFD-induced obesity,elucidating the critical role of the gut microbiota and its metabolites in the toxic effects of CP.
文摘BACKGROUND Colorectal cancer(CRC)is the second leading cause of cancer-related deaths worldwide with an alarming rise in early-onset CRC(eoCRC)over the past several decades.Unlike late-onset CRC,the drivers behind eoCRC remain less clear.While certain risk factors such as obesity and smoking have demonstrated a relatively strong association with eoCRC in the literature,some studies have challenged these associations,emphasizing the need for additional studies.METHODS This cross-sectional study used de-identified data from the National Health and Nutrition Examination Survey(1999-2023),including 30321 United States adults aged 18 to 49 years.Participants with missing key variables were excluded.Standardized protocols were used to collect demographic,lifestyle,anthropo-metric[body mass index(BMI),body roundness index(BRI),waist circumference(WC)],and self-reported CRC data.Logistic regression and propensity score matching assessed associations between obesity-related parameters and eoCRC.Statistical analyses were performed in R and Stata,with P<0.05 defined as significant.RESULTS Of 30321 participants,48 received a diagnosis of eoCRC.Patients with eoCRC were older(mean age 39.96 years vs 34.36 years;P<0.001)and had higher WC and BRI.None of the eoCRC patients were heavy drinkers(P=0.006).Unadjusted models demonstrated significant associations of eoCRC with BRI quartiles,as well as BMI-defined obesity,WC,and smoking.In unadjusted models,BRI remained the strongest independent predictor;those in the highest BRI quartiles had over 10-fold greater odds of eoCRC.In fully adjusted models,BRI remained significant,but BMI-and waist-based obesity were not.CONCLUSION BRI is a stronger predictor of eoCRC risk compared to other obesity indices and is a superior tool for identifying young individuals at higher risk of CRC.
文摘Primary biliary cholangitis(PBC)is a chronic autoimmune cholestatic liver disease characterized by progressive bile duct destruction,leading to fibrosis,cirrhosis,and eventual liver failure.Over the past two decades,significant advancements have paved the way for novel therapeutic strategies.Ursodeoxycholic acid(UDCA)has been the cornerstone of PBC management,improving survival and delaying disease progression in most patients.However,up to 40%of patients demonstrate an inadequate response to UDCA,necessitating additional treatment options.Obeticholic acid(OCA),a farnesoid X receptor agonist,has emerged as a second-line therapy,showing efficacy in reducing alkaline phosphatase levels and improving liver biochemistry.Beyond UDCA and OCA,a new wave of therapeutic agents are reshaping the PBC landscape.These include fibrates,peroxisome proliferator-activated receptor agonists and novel immunomodulatory drugs aimed at reducing autoimmune-mediated liver injury.Bile acid transport inhibitors,anti-fibrotic agents,and gut microbiome-targeted therapies are also under investigation,offering hope for personalized treatment approaches.This review highlights the evolution of PBC therapy,emphasizing the unmet needs of patients with refractory disease and the potential of emerging therapies to improve outcomes.As the therapeutic landscape continues to expand,optimizing treatment strategies through precision medicine holds the promise of transforming the management of PBC.
基金supported by the National Key Research and Development Program of China(No.2021YFA1600304)Joint Fund for Regional Innovation and Development(No.U20A2073)+4 种基金National Natural Science Foundation of China(Nos.22373048,21973038,61904119 and 22105089)Jiangxi Provincial Key Laboratory of Functional Molecular Materials Chemistry(No.20212BCD42018)US National Science Foundation(NSF,No.CHE-2055499)the Interdisciplinary program of Wuhan National High Magnetic Field Center(No.WHMFC202133)the support of the NSF Research Traineeship Program(No.DGE-2152168)。
文摘Two CoⅡ-based complexes,{[Co(dps)_(2)(N_(3))_(2)]·H_(2)O}_n(1)and[Co(dps)_(2)(N_(3))_(2)]_n(2),show a 1D chain and a 3D network,respectively.The central CoⅡions in the complexes have the same coordination environment with the[Co(dps)_(4)(N_(3))_(2)]unit.Although the differences in crystal parameters are nearly negligible,their magnetic properties are very different.AC susceptibility data show that 1 behaves as a typical field-induced single-ion magnet(SIM)with the out-of-phase(χ_(M)”)signals,while 2 shows ac signals ofχ_(M)”without peaks even under applied dc filed within our measurement window.Far-IR magneto-spectra(FIRMS)show strong spin-phonon couplings at 0 T in 2,likely making the magnetic relaxation in 2 fast,while the couplings are negligible in 1.Small spin-phonon coupling in 1 likely leads to slower magnetic relaxation,making 1 a SIM.The difference in the properties is due to the structural rigidity of 2 in its 3D network,leading to stronger spin-phonon coupling.Combined high-field EPR(HF-EPR)and FIRMS studies give spin-Hamiltonian parameters,including D=64.0(9)cm^(-1),|E|=15.7(2)cm^(-1)for 1 and D=80.0(2)cm^(-1),|E|=19.0(1)cm^(-1)for 2.
文摘This editorial comment is on the article by Xu et al.It offers an in-depth analysis of liver function assessment tools and their prognostic roles in non-malignant liver diseases,with a focus on the albumin-bilirubin(ALBI)score.ALBI’s components,grading system,and clinical relevance across various liver conditions are reviewed and compared with traditional models such as the Child-Pugh and model for end-stage liver disease scores.We included recent studies evaluating ALBI’s role in estimating liver function,suggesting it may help differentiate patients who appear similar under other staging systems,and assist in guiding clinical decisions.Although ALBI is primarily used as an indicator of hepatic reservoir in hepatocellular carcinoma,it has been demonstrated a positive correlation with overall survival,tumor recurrence,and post-hepatectomy liver failure in patients undergoing potentially curative treatments such as liver resection,liver transplantation,and local ablation.Moreover,several studies suggest that ALBI can also predict survival outcomes,treatment-related toxicity,and liver-related complications in patients receiving trans-arterial chemoembolization,radioembolization,external-beam radiotherapy,or systemic therapies.Its growing use in nonmalignant liver diseases,including primary biliary cholangitis,cirrhosis,acute and chronic liver failure,and viral hepatitis highlights the need for large,prospective studies.Further studies are warranted to validate the integration of ALBI into routine clinical practice and to clarify its role in guiding prognosis and treatment planning.
文摘The identification of novel biomarkers for early prostate cancer diagnosis is highly important because early detection and treatment are critical for the medical management of patients. Disruption in the continuity of both the basal cell layer and basement membrane is essential for the progression of high-grade prostatic intraepithelial neoplasia （HGPIN） to invasive adenocarcinoma in human prostate. The molecules involved in the conversion to an invasive phenotype are the subject of intense scrutiny. We have previously reported that matrix metalloproteinase-26 （MMP-26） promotes the invasion of human prostate cancer cells via the cleavage of basement membrane proteins and by activating the zymogen form of MMP-9. Furthermore, we have found that tissue inhibitor of metalloproteinases-4 （TIMP-4） is the most potent endogenous inhibitor of MMP-26. Here we demonstrate higher （p〈0.0001） MMP-26 and TIMP-4 expression in HGPIN and cancer, compared to non-neoplastic acini. Their expression levels are highest in HGPIN, but decline in invasive cancer （p〈0.001 for each） in the same tissues. Immunohistochemical staining of serial prostate cancer tissue sections suggests colocalization of MMP-26 and TIMP-4. The present study indicates that MMP-26 and TIMP-4 may play an integral role during the conversion of HGPIN to invasive cancer and may also serve as markers for early prostate cancer diagnosis.
文摘State-supported programs providing loans and scholarships in exchange for service in under-served areas provide an important source of financial support for medical students while encouraging them to select careers in primary care. The purpose of this research was to seek a better understanding of these often unheralded but important state sources of support, and learn if they have continued to grow in the twenty-first century. Administrative data were obtained on state-supported programs operating in 2008 that provided financial support to students, resident or practicing physicians, physician assistants, nurse practitioners, certified nurse midwives, dentists, and licensed mental healthcare providers in exchange for service in an underserved area. The authors identified numbers, types of state-supported programs, program workforce strength, and features of state programs. In 2008, 75 state programs, operating in 37 states, collectively had 5113 program participants under contract. Loan repayment programs (n = 42, 56%) were the most common type of state-supported programs. Practitioners signed initial contracts in 2008 totaled 1173, with more non-physicians (n = 681, 58%) signing initial contracts than physicians (n = 492, 42%). Additionally, 2803 practitioners were serving in programs in 2008. Field placement was also slightly greater among non-physicians in 2008 (n = 1433, 51%) than physicians (n = 1370, 49%). State support-for-service programs remains an important source of financial assistance for those willing to make service commitments in underserved areas. Moreover, these programs continue to increase in size, even amidst the economic malaise, and provide an obligated primary care workforce in underserved areas.
基金This work was supported by NIH Grants AI023007 and GM122698All NMR experiments were carried out at the National High Magnetic Field lab(NHMFL)supported by the NSF Cooperative Agreement DMR-1644779 and the State of Florida.
文摘Water plays an important role in many essential biological processes of membrane proteins in hydrated lipid environments.In general,the 1H polarization transfers berween water molecules and site--specific protons in proteins can be classified as coherent(via dipolar spin diffusion)and incoherent(via chemical exchange and nuclear Overhauser effect)transfers.Solid-state NMR is the technique of choice for studying such water-protein interactions in membrane-bound proteins/peptides through the detection of'H polarization transfers from water to the proteins.These polarization transfer mechanisms often exist simultaneously and are difficult to quantify individually.Here,we review water-protein polarization transfer techniques in solid state NMR with a focus on the recent progress for the direct detection of site-specific kinetic water-protein chemical exchange processes on the sub-millisecond time scale in membrane-bound proteins.The measurements of the pure chemical exchange ki-netics provide a unique opportunity to understand the role that water plays in the structure-function relationships of membrane bound species at the water-bilayer interface.In addi-tion,the perspective of chemical exchange saturation transfer(CEST)experiments in membrane-bound proteins/peptides is further discussed.
文摘Dear Editor,This letter is concerned with the role of recurrent neural networks(RNNs)on the controller design for a class of nonlinear systems.Inspired by the architectures of RNNs,the system states are stacked according to the dynamic along with time while the controller is represented as the neural network output.To build the bridge between RNNs and finite-time controller,a novel activation function is imposed on RNNs to drive the convergence of states at finite-time and propel the overall control process smoother.Rigorous stability proof is briefly provided for the convergence of the proposed finite-time controller.At last,a numerical simulation example is presented to illustrate the efficiency of the proposed strategy.Neural networks can be classified as static(feedforward)and dynamic(recurrent)nets[1].The former nets do not perform well in dealing with training data and using any information of the local data structure[2].In contrast to the feedforward neural networks,RNNs are constituted by high dimensional hidden states with dynamics.
基金supported by the National Aeronautics and Space Administration under grant number 80NSSC20K0352.
文摘An improved algorithm for computing multiphase flows is presented in which the multimaterial Moment-of-Fluid(MOF)algorithm for multiphase flows,initially described by Li et al.(2015),is enhanced addressing existing MOF difficulties in computing solutions to problems in which surface tension forces are crucial for understanding salient flow mechanisms.The Continuous MOF(CMOF)method is motivated in this article.The CMOF reconstruction method inherently removes the"checkerboard instability"that persists when using the MOF method on surface tension driven multiphase(multimaterial)flows.The CMOF reconstruction algorithm is accelerated by coupling the CMOF method to the level set method and coupling the CMOF method to a decision tree machine learning(ML)algorithm.Multiphase flow examples are shown in the two-dimensional(2D),three-dimensional(3D)axisymmetric"RZ",and 3D coordinate systems.Examples include two material and three material multiphase flows:bubble formation,the impingement of a liquid jet on a gas bubble in a cryogenic fuel tank,freezing,and liquid lens dynamics.
基金supported by the National Key R&D Program for Developing Basic Sciences(2022YFC3104802)the National Natural Science Foundation of China(Nos.42306219 and 42106020)+3 种基金the Tai Shan Scholar Pro-gram(Grant No.tstp20231237)Part of computing resources are financially supported by Laoshan Laboratory(No.LSKJ202300301)Dr.Eric P.CHASSIGNET is supported by the CAS President’s International Fellowship Initiative(PIFI)NOAA Climate Program Office MAPP Program(Award NA15OAR4310088).
文摘This study assesses the capability of a coarse-resolution ocean model to replicate the response of the Southern Ocean Meridional Overturning Circulation(MOC) to intensified westerlies,focusing on the role of the eddy transfer coefficient(κ).κ is a parameter commonly used to represent the velocities induced by unresolved eddies.Our findings reveal that a stratification-dependent κ,incorporating spatiotemporal variability,leads to the most robust eddy-induced MOC response,capturing 82% of the reference eddy-resolving simulation.Decomposing the eddy-induced velocity into its vertical variation(VV) and spatial structure(SS) components unveils that the enhanced eddy compensation response primarily stems from an augmented SS term,while the introduced VV term weakens the response.Furthermore,the temporal variability of the stratification-dependent κ emerges as a key factor in enhancing the eddy compensation response to intensified westerlies.The experiment with stratification-dependent κ exhibits a more potent eddy compensation response compared to the constant κ,attributed to the structure of κ and the vertical variation of the density slope.These results underscore the critical role of accurately representing κ in capturing the response of the Southern Ocean MOC and emphasize the significance of the isopycnal slope in modulating the eddy compensation mechanism.
文摘In a time characterized by the availability of vast amounts of data,the effective utilization of information is critical for timely decision-making in military operations.However,processing large amounts of data requires computational resources and time.Therefore,decision makers have used data-centric technologies to take advantage of public and private data sources to support military operations.This survey explores the integration and application of data-centric technologies,such as data analytics,data science,and machine learning,to optimize decision-making workflows within military contexts supporting the deployment of military assets and resources.To address the information gap,this article presents a literature review,specifically a survey.Our survey examines the use of the mentioned technologies to process and analyze information that contributes to the phases of situational awareness,and planning in military environments.We then introduce a taxonomy of the approaches associated with implementing these technologies in military scenarios.Furthermore,we discuss relevant factors for the seamless integration of data-centric technologies into military decision-making processes,and reveal the importance of specialized personnel,architectures,and cybersecurity issues in the task of developing prototypes and models.The findings of this paper aim to provide valuable insights for military institutions,offering a deeper understanding of the use of data-centric technologies as innovative practices to enhance the effectiveness of military decision-making.
文摘Intensive care unit-acquired weakness(ICU-AW)is a prevalent issue in critical care,leading to significant muscle atrophy and functional impairment.Aiming to address this,Neuromuscular Electrical Stimulation(NMES)has been explored as a therapy.This systematic review assesses NMES's safety and effectiveness in enhancing functional capacity and mobility in pre-and post-cardiac surgery patients.NMES was generally safe and feasible,with intervention sessions varying in frequency and duration.Improvements in muscle strength and 6-minute walking test distances were observed,particularly in preoperative settings,but postoperative benefits were inconsistent.NMES showed promise in preventing muscle loss and improving strength,although its impact on overall functional capacity remained uncertain.Challenges such as short ICU stays and body composition affecting NMES efficacy were noted.NMES also holds potential for other conditions like cerebral palsy and stroke.Further research is needed to optimize NMES protocols and better understand its full benefits in preventing ICU-AW and improving patient outcomes.
基金part supported by grants from the National Natural Science Foundation of China(Grant Nos.42222502 and 42075028)grants from the National Science Foundation(AGS-2032542 and AGS-2202875)。
文摘In this study,we put forward a radiative-convective-transportive energy balance model of a gray atmosphere to examine individual roles of the greenhouse effect of water vapor,vertical convection,and atmospheric poleward energy transport as well as their combined effects for a quasi-linear relationship between the outgoing longwave radiation(OLR)and surface temperature(T_(S)).The greenhouse effect of water vapor enhances the meridional gradient of surface temperature,thereby directly contributing to a quasi-linear OLR-T_(S) relationship.The atmospheric poleward energy transport decreases the meridional gradient of surface temperature.As a result of the poleward energy transport,tropical(high-latitude)atmosphere-surface columns emit less(more)OLR than the solar energy input at their respective locations,causing a substantial reduction of the meridional gradient of the OLR.The combined effect of reducing the meridional gradients of both OLR and surface temperature by the poleward energy transport also contributes to the quasi-linear OLR-T_(S) relationship.Vertical convective energy transport reduces the meridional gradient of surface temperature without affecting the meridional gradient of OLR,thereby suppressing part of the reduction to the increasing rate of OLR with surface temperature by the greenhouse effect of water vapor and poleward energy transport.Because of the nature of the energy balance in the climate system,such a quasi-linear relationship is also a good approximation for the relationship between the annual-mean net downward solar energy flux at the top of the atmosphere and surface temperature.
文摘In pursuit of higher energy density,lower cost,longer lifespan and safety,remarkable research efforts have been taken to innovate various types of energy storage materials/devices,especially metal-ion batteries such as Li-ion batteries(LIBs).One of the major challenges is to elucidate the working mechanisms and/or the controlling factors of any new material in a full battery,which requires adequate characterization/diagnosis techniques.Among the numerous electrochemical ex-situ and insitu characterization techniques,magnetic resonance techniques,including nuclear magnetic resonance(NMR),magnetic resonance imaging(MRI)and electron paramagnetic resonance(EPR),are unique in terms of providing structural information at the atomic level and real-time phase and morphology evolution and characterizing ionic motion at various timescales.This special issue is dedicated to an editorial and a selection of papers on the theme of investigating energy storage materials/devices using magnetic resonance techniques.As the vip editors of this special issue,we are honored to introduce the following high-quality research articles and review articles.
基金supported by the National Natural Science Foundation of China(Grant Nos.11774303 and 11574373)the financial support from“15th Graduate Research Innovation Project”from Yunnan Universityfinancial support from the Joint Fund of Yunnan Provincial Science and Technology Department(Grant No.2019FY003008)。
文摘For designing low-impedance magnetic tunnel junctions(MTJs),it has been found that tunneling magnetoresistance strongly correlates with the insulating barrier thickness,imposing a fundamental problem about the relationship between spin polarization of ferromagnet and the insulating barrier thickness in MTJs.Here,we investigate the influence of alumina barrier thickness on tunneling spin polarization(TSP)through a combination of theoretical calculations and experimental verification.Our simulating results reveal a significant impact of barrier thickness on TSP,exhibiting an oscillating decay of TSP with the barrier layer thinning.Experimental verification is realized on FeNi/AlO_(x)/Al superconducting tunnel junctions to directly probe the spin polarization of FeNi ferromagnet using Zeeman-split tunneling spectroscopy technique.These findings provide valuable insights for designs of high-performance spintronic devices,particularly in applications such as magnetic random access memories,where precise control over the insulating barrier layer is crucial.
