Froth flotation is often used for fine-particle separation,but its process efficiency rapidly decreases with decreasing particle size.The efficient separation of ultrafine particles(UFPs)has been a major challenge in ...Froth flotation is often used for fine-particle separation,but its process efficiency rapidly decreases with decreasing particle size.The efficient separation of ultrafine particles(UFPs)has been a major challenge in the mineral processing field for many years.In recent years,the use of surface nanobubbles in the flotation process has been recognized as an effective approach for enhancing the recovery of UFPs.Compared with traditional macrobubbles,nanobubbles possess unique surface and bulk characteristics,and their effects on the UFP flotation behavior have been a topic of intensive research.This review article is focused on the studies on various unique characteristics of nanobubbles and their mechanisms of enhancing the UFP flotation.The purpose of this article is to summarize the major achievements on the two topics and pinpoint future research needs for a better understanding of the fundamentals of surface nanobubble flotation and developing more feasible and efficient processes for fine and UFPs.展开更多
We analyzed a novel cationic collector using chemical plant byproducts,such as cetyltrimethylammonium bromide(CTAB)and dibutyl phthalate(DBP).Our aim is to establish a highly effective and economical process for the r...We analyzed a novel cationic collector using chemical plant byproducts,such as cetyltrimethylammonium bromide(CTAB)and dibutyl phthalate(DBP).Our aim is to establish a highly effective and economical process for the removal of quartz from collophane.A microflotation test with a 25 mg·L^(−1)collector at pH value of 6-10 demonstrates a considerable difference in the floatability of pure quartz and fluorapatite.Flotation tests for a collophane sample subjected to the first reverse flotation for magnesium removal demonstrates that a rough flotation process(using a 0.4 kg·t−1 new collector at pH=6)results in a collophane concentrate with 29.33wt%P_(2)O_(5)grade and 12.66wt%SiO2 at a 79.69wt%P_(2)O_(5)recovery,providing desirable results.Mechanism studies using Fourier transform infrared spectroscopy,zeta potential,and contact angle measurements show that the adsorption capacity of the new collector for quartz is higher than that for fluorapatite.The synergistic effect of DBP increases the difference in hydrophobicity between quartz and fluorapatite.The maximum defoaming rate of the novel cationic collector reaches 142.8 mL·min−1.This is considerably higher than that of a conventional cationic collector.展开更多
Backgrounds ST-elevation myocardial infarction （STEMI） guidelines recommend reperfusion by primary percutaneous coronary in- tervention （PCI） ≤ 90 min from time of first medical contact （FMC）. This strategy is ...Backgrounds ST-elevation myocardial infarction （STEMI） guidelines recommend reperfusion by primary percutaneous coronary in- tervention （PCI） ≤ 90 min from time of first medical contact （FMC）. This strategy is challenging in rural areas lacking a nearby PCI-capable hospital. Recommended reperfusion times can be achieved for STEMI patients presenting in rural areas without a nearby PCI-capable hospital by ground transportation to a central PCI-capable hospital by use of protocol-driven emergency medical service （EMS） STEMI field triage protocol. Methods Sixty STEMI patients directly transported by EMS from three rural counties （Nassau, Camden and Charlton Counties） within a 50-mile radius of University of Florida Health-Jacksonville （UFHJ） from 01/01/2009 to 12/31/2013 were identified from its PCI registry. The STEMI field triage protocol incorporated three elements： （1） a cooperative agreement between each of the rural emergency medical service （EMS） agency and UFHJ; （2） performance of a pre-hospital ECG to facilitate STEMI identification and laboratory activation; and （3） direct transfer by ground transportation to the UFHJ cardiac catheterization laboratory. FMC-to-device （FMC2D）, door-to-device （D2D）, and transit times, the day of week, time of day, and EMS shift times were recorded, and odds ratio （OR） of achieving FMC2D times was calculated. Results FMC2D times were shorter for in-state STEMIs （81 ± 17 vs. 87± 19 min）, but D2D times were similar （37 ± 18 vs. 39 ± 21 min）. FMC2D 〈 90 min were achieved in 82.7% in-state STEMIs compared to 52.2% for out-of-state STEMIs （OR = 4.4, 95% CI： 1.24-15.57; P = 0.018）. FMC2D times were homogenous after adjusting for weekday vs. weekend, EMS shift times. Nine patients did not meet FMC2D ≤ 90 min. Six were within 10 min of target; all patient achieved FMC2D 〈 120 min. Conclusions Guideline-compliant FMC2D ≤90 min is achievable for rural STEMI patients within a 50 mile radius of a PCI-capable hospital by use of protocol-driven EMS ground transportation. As all patients achieved a FMC2D time 〈 120 min, bypass of non-PCI capable hospitals may be reasonable in this situation.展开更多
Parkinson’s disease(PD),characterized by loss of nigrostriatal dopaminergic neurons,is one of the most predominant neurodegenerative diseases affecting the elderly population worldwide.The concept of stem cell therap...Parkinson’s disease(PD),characterized by loss of nigrostriatal dopaminergic neurons,is one of the most predominant neurodegenerative diseases affecting the elderly population worldwide.The concept of stem cell therapy in managing neurodegenerative diseases has evolved over the years and has recently rapidly progressed.Neural stem cells(NSCs)have a few key features,including selfrenewal,proliferation,and multipotency,which make them a promising agent targeting neurodegeneration.It is generally agreed that challenges for NSC-based therapy are present at every stage of the transplantation process,including preoperative cell preparation and quality control,perioperative procedures,and postoperative graft preservation,adherence,and overall therapy success.In this review,we provided a comprehensive,careful,and critical discussion of experimental and clinical data alongside the pros and cons of NSC-based therapy in PD.Given the state-of-the-art accomplishments of stem cell therapy,gene therapy,and nanotechnology,we shed light on the perspective of complementing the advantages of each process by developing nano-stem cell therapy,which is currently a research hotspot.Although various obstacles and challenges remain,nano-stem cell therapy holds promise to cure PD,however,continuous improvement and development from the stage of laboratory experiments to the clinical application are necessary.展开更多
This review covers extensively the synthesis&surface modification,characterization,and application of magnetic nanoparticles.For biomedical applications,consideration should be given to factors such as design stra...This review covers extensively the synthesis&surface modification,characterization,and application of magnetic nanoparticles.For biomedical applications,consideration should be given to factors such as design strategies,the synthesis process,coating,and surface passivation.The synthesis method regulates post-synthetic change and specific applications in vitro and in vivo imaging/diagnosis and pharmacotherapy/administration.Special insights have been provided on biodistribution,pharmacokinetics,and toxicity in a living system,which is imperative for their wider application in biology.These nanoparticles can be decorated with multiple contrast agents and thus can also be used as a probe for multi-mode imaging or double/triple imaging,for example,MRI-CT,MRI-PET.Similarly loading with different drug molecules/dye/fluorescent molecules and integration with other carriers have found application not only in locating these particles in vivo but simultaneously target drug delivery/hyperthermia inside the body.Studies are underway to collect the potential of these magnetically driven nanoparticles in various scientific fields such as particle interaction,heat conduction,imaging,and magnetism.Surely,this comprehensive data will help in the further development of advanced techniques for theranostics based on high-performance magnetic nanoparticles and will lead this research area in a new sustainable direction.展开更多
Towards implanted deep brain stimulation(D B S):The human brain i s a complex network of 86 billion neurons and 85 billion nonneuronal cells and they are coordinated in a well-defined ratio(1:1)which is required for d...Towards implanted deep brain stimulation(D B S):The human brain i s a complex network of 86 billion neurons and 85 billion nonneuronal cells and they are coordinated in a well-defined ratio(1:1)which is required for desired body functions.The connectivity among neuronal cells secretes neurotransmitters(e.g.,dopamine)to establish a perfect connection between the brain and a peripheral system i.e.,motor coordination.展开更多
Human coronavirus infection getting into the brain:By February 2022,the severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)infection,causing the coronavirus disease 2019(COVID-19)outbreak,has infected around 4...Human coronavirus infection getting into the brain:By February 2022,the severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)infection,causing the coronavirus disease 2019(COVID-19)outbreak,has infected around 415 million people,and caused~5.8 million deaths worldwide(WHO,https://covid19.who.int/).As SARS-CoV-2 replicates during the infection,it undergoes genetic mutation to generate variants with varying characteristics and mutation frequencies.The emerging,over time,new variants that differ with transmissibility,immunity,and infection severity pose continuous challenges to established COVID-19 management strategies and regulations.Several SARS-CoV-2 variants such as Omicron(B.1.1.529),Delta(B.1.617.2),UK(B.1.17),South Africa(B.1.351),Brazil(P.1),and New York B.1.525-B.1.526 were detected worldwide and accelerated severity of COVID-19 pandemic(Figure 1A;McQuaid et al.,2021).展开更多
Need for Alzheimer's disease progression monitoring:Alzheimer's disease(AD)is an irreversible progressive brain disorder that causes severe and incurable neuro-impairment.The World Health Organization estimate...Need for Alzheimer's disease progression monitoring:Alzheimer's disease(AD)is an irreversible progressive brain disorder that causes severe and incurable neuro-impairment.The World Health Organization estimates that 55 million people are affected by AD dementia by 2020 which may exceed 78 million by 2030 and 139 in 2050.The estimated cost to manage AD is above US$1.3 trillion,which will further increase to US$2.8 trillion by 2030.展开更多
Timely reperfusion for patients with an ST-elevation myocardial infarction （STEMI） reduces myocardial cell loss resulting in preserved LV performance, a reduced incidence of congestive heart failure, and significant...Timely reperfusion for patients with an ST-elevation myocardial infarction （STEMI） reduces myocardial cell loss resulting in preserved LV performance, a reduced incidence of congestive heart failure, and significantly lower early and late mortality, while conversely, any delay in reperfusion has a deleterious effect on morbidity and mortality.展开更多
Networked Control Systems (NCSs) have been implemented in several different industries. The integration with advanced communication networks and computing techniques allows for the enhancement of efficiency of industr...Networked Control Systems (NCSs) have been implemented in several different industries. The integration with advanced communication networks and computing techniques allows for the enhancement of efficiency of industrial control systems. Despite all the advantages that NCSs bring to industry, they remain at risk to a spectrum of physical and cyber-attacks. In this paper, we elaborate on security vulnerabilities of NCSs, and examine how these vulnerabilities may be exploited when attacks occur. A general model of NCS designed with three different controllers, i.e., proportional-integral-derivative (PID) controllers, Model Predictive control (MPC) and Emotional Learning Controller (ELC) are studied. Then three different types of attacks are applied to evaluate the system performance. For the case study, a networked pacemaker system using the Zeeman nonlinear heart model (ZHM) as the plant combined with the above-mentioned controllers to test the system performance when under attacks. The results show that with Emotional Learning Controller (ELC), the pacemaker is able to track the ECG signal with high fidelity even under different attack scenarios.展开更多
Machine learning (ML) and nanotechnology interfacing are exploring opportunities for cancer treatment strategies. To improve cancer therapy, this article investigates the synergistic combination of Graphene Oxide (GO)...Machine learning (ML) and nanotechnology interfacing are exploring opportunities for cancer treatment strategies. To improve cancer therapy, this article investigates the synergistic combination of Graphene Oxide (GO)-based devices with ML techniques. The production techniques and functionalization tactics used to modify the physicochemical characteristics of GO for specific drug delivery are explained at the outset of the investigation. GO is a great option for treating cancer because of its natural biocompatibility and capacity to absorb medicinal chemicals. Then, complicated biological data are analyzed using ML algorithms, which make it possible to identify the best medicine formulations and individualized treatment plans depending on each patient's particular characteristics. The study also looks at optimizing and predicting the interactions between GO carriers and cancer cells using ML. Predictive modeling helps ensure effective payload release and therapeutic efficacy in the design of customized drug delivery systems. Furthermore, tracking treatment outcomes in real time is made possible by ML algorithms, which permit adaptive modifications to therapy regimens. By optimizing medication doses and delivery settings, the combination of ML and GO in cancer therapy not only decreases adverse effects but also enhances treatment accuracy.展开更多
According to the National Institutes of Health(NIH),the initiative of The Rapid Acceleration of Diagnostics Tech and Advanced Technology Platforms(RADxTech/ATP)program was established to promote research and developme...According to the National Institutes of Health(NIH),the initiative of The Rapid Acceleration of Diagnostics Tech and Advanced Technology Platforms(RADxTech/ATP)program was established to promote research and development(R&D)in the field of investigating selective,sensitive,and affordable sensing technologies for coronavirus disease 2019(COVID-19)diagnostics.This is a goaloriented approach toward point-of-care testing(POCT)and severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)infection management applications.Till May 2022,RADxTech/ATP has been involved in 1.9 billion tests production,44 FDA authorized tests,first over-the-counter test for POCT and home-based testing,and>100 companies dedicated to smart sensor development(https://www.nibib.nih.gov/covid-19/radx-tech-program/radx-tech-dashboard).Despite such outstanding growth,COVID-19 management is far from in control due to SARS-CoV-2 mutations,virus presence in life systems(including human-to-human transmission,water,food,animal,and air[mainly indoor premises])。展开更多
A method is proposed for real-time vision-based localization in the 360°area around a three-dimensional(3D)reference object with a single camera.The problem is split into three subproblems.First,360°3D objec...A method is proposed for real-time vision-based localization in the 360°area around a three-dimensional(3D)reference object with a single camera.The problem is split into three subproblems.First,360°3D object recognition is proposed,in which a computer vision solution can recognize a reference object from all possible 360°locations.Second,360°pose estimation is presented,in which the pose of a robot at all locations is estimated.Third,a 360°localization application is integrated with a closed-loop real-time trajectory tracking controller.The successful results of simulations and real experiments of trajectory tracking are also presented.展开更多
基金funded by a number of government and industrial grants,particularly the grant from the National Natural Science Foundation of China(No.51804188)。
文摘Froth flotation is often used for fine-particle separation,but its process efficiency rapidly decreases with decreasing particle size.The efficient separation of ultrafine particles(UFPs)has been a major challenge in the mineral processing field for many years.In recent years,the use of surface nanobubbles in the flotation process has been recognized as an effective approach for enhancing the recovery of UFPs.Compared with traditional macrobubbles,nanobubbles possess unique surface and bulk characteristics,and their effects on the UFP flotation behavior have been a topic of intensive research.This review article is focused on the studies on various unique characteristics of nanobubbles and their mechanisms of enhancing the UFP flotation.The purpose of this article is to summarize the major achievements on the two topics and pinpoint future research needs for a better understanding of the fundamentals of surface nanobubble flotation and developing more feasible and efficient processes for fine and UFPs.
基金the financial support from the National Natural Science Foundation of China(No.51804188)the support of the Yunnan Yuntianhua Co.,Ltd.,China,for providing the phosphate samples.
文摘We analyzed a novel cationic collector using chemical plant byproducts,such as cetyltrimethylammonium bromide(CTAB)and dibutyl phthalate(DBP).Our aim is to establish a highly effective and economical process for the removal of quartz from collophane.A microflotation test with a 25 mg·L^(−1)collector at pH value of 6-10 demonstrates a considerable difference in the floatability of pure quartz and fluorapatite.Flotation tests for a collophane sample subjected to the first reverse flotation for magnesium removal demonstrates that a rough flotation process(using a 0.4 kg·t−1 new collector at pH=6)results in a collophane concentrate with 29.33wt%P_(2)O_(5)grade and 12.66wt%SiO2 at a 79.69wt%P_(2)O_(5)recovery,providing desirable results.Mechanism studies using Fourier transform infrared spectroscopy,zeta potential,and contact angle measurements show that the adsorption capacity of the new collector for quartz is higher than that for fluorapatite.The synergistic effect of DBP increases the difference in hydrophobicity between quartz and fluorapatite.The maximum defoaming rate of the novel cationic collector reaches 142.8 mL·min−1.This is considerably higher than that of a conventional cationic collector.
文摘Backgrounds ST-elevation myocardial infarction （STEMI） guidelines recommend reperfusion by primary percutaneous coronary in- tervention （PCI） ≤ 90 min from time of first medical contact （FMC）. This strategy is challenging in rural areas lacking a nearby PCI-capable hospital. Recommended reperfusion times can be achieved for STEMI patients presenting in rural areas without a nearby PCI-capable hospital by ground transportation to a central PCI-capable hospital by use of protocol-driven emergency medical service （EMS） STEMI field triage protocol. Methods Sixty STEMI patients directly transported by EMS from three rural counties （Nassau, Camden and Charlton Counties） within a 50-mile radius of University of Florida Health-Jacksonville （UFHJ） from 01/01/2009 to 12/31/2013 were identified from its PCI registry. The STEMI field triage protocol incorporated three elements： （1） a cooperative agreement between each of the rural emergency medical service （EMS） agency and UFHJ; （2） performance of a pre-hospital ECG to facilitate STEMI identification and laboratory activation; and （3） direct transfer by ground transportation to the UFHJ cardiac catheterization laboratory. FMC-to-device （FMC2D）, door-to-device （D2D）, and transit times, the day of week, time of day, and EMS shift times were recorded, and odds ratio （OR） of achieving FMC2D times was calculated. Results FMC2D times were shorter for in-state STEMIs （81 ± 17 vs. 87± 19 min）, but D2D times were similar （37 ± 18 vs. 39 ± 21 min）. FMC2D 〈 90 min were achieved in 82.7% in-state STEMIs compared to 52.2% for out-of-state STEMIs （OR = 4.4, 95% CI： 1.24-15.57; P = 0.018）. FMC2D times were homogenous after adjusting for weekday vs. weekend, EMS shift times. Nine patients did not meet FMC2D ≤ 90 min. Six were within 10 min of target; all patient achieved FMC2D 〈 120 min. Conclusions Guideline-compliant FMC2D ≤90 min is achievable for rural STEMI patients within a 50 mile radius of a PCI-capable hospital by use of protocol-driven EMS ground transportation. As all patients achieved a FMC2D time 〈 120 min, bypass of non-PCI capable hospitals may be reasonable in this situation.
基金Supported by Narodowe Centrum Nauki,No.2021/42/E/NZ7/00246.
文摘Parkinson’s disease(PD),characterized by loss of nigrostriatal dopaminergic neurons,is one of the most predominant neurodegenerative diseases affecting the elderly population worldwide.The concept of stem cell therapy in managing neurodegenerative diseases has evolved over the years and has recently rapidly progressed.Neural stem cells(NSCs)have a few key features,including selfrenewal,proliferation,and multipotency,which make them a promising agent targeting neurodegeneration.It is generally agreed that challenges for NSC-based therapy are present at every stage of the transplantation process,including preoperative cell preparation and quality control,perioperative procedures,and postoperative graft preservation,adherence,and overall therapy success.In this review,we provided a comprehensive,careful,and critical discussion of experimental and clinical data alongside the pros and cons of NSC-based therapy in PD.Given the state-of-the-art accomplishments of stem cell therapy,gene therapy,and nanotechnology,we shed light on the perspective of complementing the advantages of each process by developing nano-stem cell therapy,which is currently a research hotspot.Although various obstacles and challenges remain,nano-stem cell therapy holds promise to cure PD,however,continuous improvement and development from the stage of laboratory experiments to the clinical application are necessary.
基金Parveen Kumar acknowledges the department of science and technology(DST)New Delhi for the INSPIRE(Innovation in Science Pursuit for Inspired Research)-Faculty grant.
文摘This review covers extensively the synthesis&surface modification,characterization,and application of magnetic nanoparticles.For biomedical applications,consideration should be given to factors such as design strategies,the synthesis process,coating,and surface passivation.The synthesis method regulates post-synthetic change and specific applications in vitro and in vivo imaging/diagnosis and pharmacotherapy/administration.Special insights have been provided on biodistribution,pharmacokinetics,and toxicity in a living system,which is imperative for their wider application in biology.These nanoparticles can be decorated with multiple contrast agents and thus can also be used as a probe for multi-mode imaging or double/triple imaging,for example,MRI-CT,MRI-PET.Similarly loading with different drug molecules/dye/fluorescent molecules and integration with other carriers have found application not only in locating these particles in vivo but simultaneously target drug delivery/hyperthermia inside the body.Studies are underway to collect the potential of these magnetically driven nanoparticles in various scientific fields such as particle interaction,heat conduction,imaging,and magnetism.Surely,this comprehensive data will help in the further development of advanced techniques for theranostics based on high-performance magnetic nanoparticles and will lead this research area in a new sustainable direction.
基金Authors acknowledge respective affiliated institutions for providing facilities and support.
文摘Towards implanted deep brain stimulation(D B S):The human brain i s a complex network of 86 billion neurons and 85 billion nonneuronal cells and they are coordinated in a well-defined ratio(1:1)which is required for desired body functions.The connectivity among neuronal cells secretes neurotransmitters(e.g.,dopamine)to establish a perfect connection between the brain and a peripheral system i.e.,motor coordination.
文摘Human coronavirus infection getting into the brain:By February 2022,the severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)infection,causing the coronavirus disease 2019(COVID-19)outbreak,has infected around 415 million people,and caused~5.8 million deaths worldwide(WHO,https://covid19.who.int/).As SARS-CoV-2 replicates during the infection,it undergoes genetic mutation to generate variants with varying characteristics and mutation frequencies.The emerging,over time,new variants that differ with transmissibility,immunity,and infection severity pose continuous challenges to established COVID-19 management strategies and regulations.Several SARS-CoV-2 variants such as Omicron(B.1.1.529),Delta(B.1.617.2),UK(B.1.17),South Africa(B.1.351),Brazil(P.1),and New York B.1.525-B.1.526 were detected worldwide and accelerated severity of COVID-19 pandemic(Figure 1A;McQuaid et al.,2021).
基金Florida Polytechnic University,Lakeland,USA for providing support。
文摘Need for Alzheimer's disease progression monitoring:Alzheimer's disease(AD)is an irreversible progressive brain disorder that causes severe and incurable neuro-impairment.The World Health Organization estimates that 55 million people are affected by AD dementia by 2020 which may exceed 78 million by 2030 and 139 in 2050.The estimated cost to manage AD is above US$1.3 trillion,which will further increase to US$2.8 trillion by 2030.
文摘Timely reperfusion for patients with an ST-elevation myocardial infarction （STEMI） reduces myocardial cell loss resulting in preserved LV performance, a reduced incidence of congestive heart failure, and significantly lower early and late mortality, while conversely, any delay in reperfusion has a deleterious effect on morbidity and mortality.
文摘Networked Control Systems (NCSs) have been implemented in several different industries. The integration with advanced communication networks and computing techniques allows for the enhancement of efficiency of industrial control systems. Despite all the advantages that NCSs bring to industry, they remain at risk to a spectrum of physical and cyber-attacks. In this paper, we elaborate on security vulnerabilities of NCSs, and examine how these vulnerabilities may be exploited when attacks occur. A general model of NCS designed with three different controllers, i.e., proportional-integral-derivative (PID) controllers, Model Predictive control (MPC) and Emotional Learning Controller (ELC) are studied. Then three different types of attacks are applied to evaluate the system performance. For the case study, a networked pacemaker system using the Zeeman nonlinear heart model (ZHM) as the plant combined with the above-mentioned controllers to test the system performance when under attacks. The results show that with Emotional Learning Controller (ELC), the pacemaker is able to track the ECG signal with high fidelity even under different attack scenarios.
文摘Machine learning (ML) and nanotechnology interfacing are exploring opportunities for cancer treatment strategies. To improve cancer therapy, this article investigates the synergistic combination of Graphene Oxide (GO)-based devices with ML techniques. The production techniques and functionalization tactics used to modify the physicochemical characteristics of GO for specific drug delivery are explained at the outset of the investigation. GO is a great option for treating cancer because of its natural biocompatibility and capacity to absorb medicinal chemicals. Then, complicated biological data are analyzed using ML algorithms, which make it possible to identify the best medicine formulations and individualized treatment plans depending on each patient's particular characteristics. The study also looks at optimizing and predicting the interactions between GO carriers and cancer cells using ML. Predictive modeling helps ensure effective payload release and therapeutic efficacy in the design of customized drug delivery systems. Furthermore, tracking treatment outcomes in real time is made possible by ML algorithms, which permit adaptive modifications to therapy regimens. By optimizing medication doses and delivery settings, the combination of ML and GO in cancer therapy not only decreases adverse effects but also enhances treatment accuracy.
基金support from the National Institute of Biomedical Imaging and Bioengineering(5T32EB009035).
文摘According to the National Institutes of Health(NIH),the initiative of The Rapid Acceleration of Diagnostics Tech and Advanced Technology Platforms(RADxTech/ATP)program was established to promote research and development(R&D)in the field of investigating selective,sensitive,and affordable sensing technologies for coronavirus disease 2019(COVID-19)diagnostics.This is a goaloriented approach toward point-of-care testing(POCT)and severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)infection management applications.Till May 2022,RADxTech/ATP has been involved in 1.9 billion tests production,44 FDA authorized tests,first over-the-counter test for POCT and home-based testing,and>100 companies dedicated to smart sensor development(https://www.nibib.nih.gov/covid-19/radx-tech-program/radx-tech-dashboard).Despite such outstanding growth,COVID-19 management is far from in control due to SARS-CoV-2 mutations,virus presence in life systems(including human-to-human transmission,water,food,animal,and air[mainly indoor premises])。
文摘A method is proposed for real-time vision-based localization in the 360°area around a three-dimensional(3D)reference object with a single camera.The problem is split into three subproblems.First,360°3D object recognition is proposed,in which a computer vision solution can recognize a reference object from all possible 360°locations.Second,360°pose estimation is presented,in which the pose of a robot at all locations is estimated.Third,a 360°localization application is integrated with a closed-loop real-time trajectory tracking controller.The successful results of simulations and real experiments of trajectory tracking are also presented.
