Diabetes is a chronic metabolic disease with a high blood glucose level,leading to both seriously acute and chronic complications.The closed-loop system is an ideal system for diabetes management.However,the large siz...Diabetes is a chronic metabolic disease with a high blood glucose level,leading to both seriously acute and chronic complications.The closed-loop system is an ideal system for diabetes management.However,the large size and high cost of the commercial systems restrict their widespread uses.Here,we present for the first time a microtube-based wearable closed-loop minisystem for diabetes management.The closed-loop minisystem includes a biosensing device,an electroosmotic micropump,and a printed circuit board(PCB)with an algorithm.The microtube-based sensing device coated on the outer surface of the microtube is inserted into subcutaneous tissue for detecting interstitial glucose;the current signal for sensing glucose is processed by the PCB to power the electroosmotic micropump intelligently for the delivery of insulin into the subcutaneous tissue via the microtube channel.The closed-loop minisystem worn on a diabetic SD rat can successfully maintain its blood glucose level within a safe level.It is expected that this new closed-loop paradigm could open up new prospects for clinical diabetes management.展开更多
基金acknowledge the National High Level Hospital Clinical Research Funding(High Quality Clinical Research Project of Peking University First Hospital,No.2022CR83)National Natural Science Foundation of China(No.52072007 and No.82130021)+4 种基金National Key Research and Development Program of China(No.2018YFB1307301)CAMS Innovation Fund for Medical Sciences(2019-I2M-5-046 and 2020-JKCS-009)PKU-Baidu Fund(2020BD026 and 2020BD044)Capital's Funds for Health Improvement and Research(CFH2022-1-4071)Beijing Young Scientist Program(BJWZYJH01201910001006)for the financial support.
文摘Diabetes is a chronic metabolic disease with a high blood glucose level,leading to both seriously acute and chronic complications.The closed-loop system is an ideal system for diabetes management.However,the large size and high cost of the commercial systems restrict their widespread uses.Here,we present for the first time a microtube-based wearable closed-loop minisystem for diabetes management.The closed-loop minisystem includes a biosensing device,an electroosmotic micropump,and a printed circuit board(PCB)with an algorithm.The microtube-based sensing device coated on the outer surface of the microtube is inserted into subcutaneous tissue for detecting interstitial glucose;the current signal for sensing glucose is processed by the PCB to power the electroosmotic micropump intelligently for the delivery of insulin into the subcutaneous tissue via the microtube channel.The closed-loop minisystem worn on a diabetic SD rat can successfully maintain its blood glucose level within a safe level.It is expected that this new closed-loop paradigm could open up new prospects for clinical diabetes management.
