Acne vulgaris is the most common skin condition associated with inflammation of the pilosebaceous unit and affects all ethnic and age groups, independent of sex, nationality, or socioeconomic status. Treatment usually...Acne vulgaris is the most common skin condition associated with inflammation of the pilosebaceous unit and affects all ethnic and age groups, independent of sex, nationality, or socioeconomic status. Treatment usually includes oral and/or physical and/or topical interventions—the last can be obtained through commercial preparations in fixed doses or as compounded creams/gels, with personalized qualitative and quantitative composition, to be unique to each patient. In this sense, ready-to-use vehicles play an important role as a timesaving strategy and to ensure maximum results from the treatment. In this paper, we present Cleoderm<sup>TM</sup> Clarifying Cream, a ready-to-use, functional semisolid vehicle for acne treatments and topical products for oily skin, to be used by compounding pharmacies. It contains ingredients that can potentiate the effects of the active ingredients added, and has a light and pleasant skin feel. The current body of evidence shows that Cleoderm<sup>TM</sup> Clarifying Cream can be an important strategy for compounding personalized acne treatments due to its multiple positive roles on decreasing sebum production, lipid peroxidation, and reactive oxygen species, inhibition of <em>Cutibacterium acnes</em> proliferation, and control of inflammation.展开更多
The use of nutraceuticals to improve skin properties and decelerate skin aging has been gaining attention among dermatologists, over the last years. In this article, we are presenting the theoretical scientific suppor...The use of nutraceuticals to improve skin properties and decelerate skin aging has been gaining attention among dermatologists, over the last years. In this article, we are presenting the theoretical scientific support for Yuliv<sup>TM</sup> Collagen Drink, a liquid supplement containing bovine type I collagen peptides, ascorbic acid and <em>Camellia sinensis</em> (green tea) extract and its benefits on the skin. The available literature shows that the ingredients contained in the supplement have the potential to improve of skin hydration, dermis collagen density, and decrease the fragmentation of the dermal collagen network—and therefore reduce wrinkles and sagging and improving elasticity. Additionally, other health benefits could also be observed, such as protection against oxidative stress, contribution to the normal function of the immune system and reducing tiredness and fatigue, and reduction of skin inflammation, improvement of elasticity and prevention of oxidation. For those benefits to be visible, it is likely that continuous use of at least 4 weeks is needed.展开更多
Acne vulgaris is a common inflammatory disease of the pilosebaceous unit, with a profound impact on the quality of life of patients. In this work, we aimed to study the safety characteristics of Cleoderm<sup>TM&...Acne vulgaris is a common inflammatory disease of the pilosebaceous unit, with a profound impact on the quality of life of patients. In this work, we aimed to study the safety characteristics of Cleoderm<sup>TM</sup>, a novel functional semisolid vehicle developed for the compounding of treatments for acne and oily skin. The primary and cumulative irritation and sensitization potential were evaluated in 54 healthy volunteers in a comparative single-blinded study, while the acnegenic and comedogenic potential of the product were assessed in 31 healthy volunteers with combination to oily skin through a non-comparative study. Cleoderm<sup>TM</sup> was applied (0.05 g/cm<sup>2</sup>) in filter paper discs in both studies. For the evaluation of the irritation and sensitization potential, the investigational product, or a control (0.9% NaCl) was applied to the right or left scapular area of the study subjects. No clinical reactions were observed during the induction or challenge phases, suggesting that Cleoderm<sup>TM</sup> presents no irritating or allergenic potential. Regarding acnegenicity and comedogenicity, no significant increase in the number of acne lesions linked to the application of the product in four areas of the face was reported, indicating that Cleoderm<sup>TM</sup> appears not to display acnegenic and comedogenic potential. Furthermore, over 60% of the study subjects exhibited a decrease in the number of acne lesions after product use. These results show that Cleoderm<sup>TM</sup> exhibited no irritating, sensitizing, acnegenic or comedogenic potential, and suggest that it can be considered safe under the study conditions and that the claims dermatologically tested, clinically tested, and non-comedogenic/acnegenic can be supported.展开更多
文摘Acne vulgaris is the most common skin condition associated with inflammation of the pilosebaceous unit and affects all ethnic and age groups, independent of sex, nationality, or socioeconomic status. Treatment usually includes oral and/or physical and/or topical interventions—the last can be obtained through commercial preparations in fixed doses or as compounded creams/gels, with personalized qualitative and quantitative composition, to be unique to each patient. In this sense, ready-to-use vehicles play an important role as a timesaving strategy and to ensure maximum results from the treatment. In this paper, we present Cleoderm<sup>TM</sup> Clarifying Cream, a ready-to-use, functional semisolid vehicle for acne treatments and topical products for oily skin, to be used by compounding pharmacies. It contains ingredients that can potentiate the effects of the active ingredients added, and has a light and pleasant skin feel. The current body of evidence shows that Cleoderm<sup>TM</sup> Clarifying Cream can be an important strategy for compounding personalized acne treatments due to its multiple positive roles on decreasing sebum production, lipid peroxidation, and reactive oxygen species, inhibition of <em>Cutibacterium acnes</em> proliferation, and control of inflammation.
文摘The use of nutraceuticals to improve skin properties and decelerate skin aging has been gaining attention among dermatologists, over the last years. In this article, we are presenting the theoretical scientific support for Yuliv<sup>TM</sup> Collagen Drink, a liquid supplement containing bovine type I collagen peptides, ascorbic acid and <em>Camellia sinensis</em> (green tea) extract and its benefits on the skin. The available literature shows that the ingredients contained in the supplement have the potential to improve of skin hydration, dermis collagen density, and decrease the fragmentation of the dermal collagen network—and therefore reduce wrinkles and sagging and improving elasticity. Additionally, other health benefits could also be observed, such as protection against oxidative stress, contribution to the normal function of the immune system and reducing tiredness and fatigue, and reduction of skin inflammation, improvement of elasticity and prevention of oxidation. For those benefits to be visible, it is likely that continuous use of at least 4 weeks is needed.
文摘Acne vulgaris is a common inflammatory disease of the pilosebaceous unit, with a profound impact on the quality of life of patients. In this work, we aimed to study the safety characteristics of Cleoderm<sup>TM</sup>, a novel functional semisolid vehicle developed for the compounding of treatments for acne and oily skin. The primary and cumulative irritation and sensitization potential were evaluated in 54 healthy volunteers in a comparative single-blinded study, while the acnegenic and comedogenic potential of the product were assessed in 31 healthy volunteers with combination to oily skin through a non-comparative study. Cleoderm<sup>TM</sup> was applied (0.05 g/cm<sup>2</sup>) in filter paper discs in both studies. For the evaluation of the irritation and sensitization potential, the investigational product, or a control (0.9% NaCl) was applied to the right or left scapular area of the study subjects. No clinical reactions were observed during the induction or challenge phases, suggesting that Cleoderm<sup>TM</sup> presents no irritating or allergenic potential. Regarding acnegenicity and comedogenicity, no significant increase in the number of acne lesions linked to the application of the product in four areas of the face was reported, indicating that Cleoderm<sup>TM</sup> appears not to display acnegenic and comedogenic potential. Furthermore, over 60% of the study subjects exhibited a decrease in the number of acne lesions after product use. These results show that Cleoderm<sup>TM</sup> exhibited no irritating, sensitizing, acnegenic or comedogenic potential, and suggest that it can be considered safe under the study conditions and that the claims dermatologically tested, clinically tested, and non-comedogenic/acnegenic can be supported.
