Cu metal and its oxides have attracted much attention for photocatalytic CO_(2)reduction reaction(CO_(2)RR),but the stability and effects of Cu oxidation states on CO_(2)RR are not fully understood.Cu^(x+)/Cu^(0)-load...Cu metal and its oxides have attracted much attention for photocatalytic CO_(2)reduction reaction(CO_(2)RR),but the stability and effects of Cu oxidation states on CO_(2)RR are not fully understood.Cu^(x+)/Cu^(0)-loaded graphitic carbon nitride(g-C_(3)N_(4))heterojunctions(Cu-CuO_(x)/g-C_(3)N_(4))are fabricated via a stepwise calcination method for efficient photocatalytic CO_(2)RR.Cu_(2)O is the main component of Cu-CuO_(x)and the mixed valence Cu includes Cu^(0),Cu^(+),and Cu^(2+),which play the role of charge trapping sites and redox catalytic centers during the photocatalytic CO_(2)RR process.The main products were CO and CH_(4)for the CO_(2)RR with production rates of 14.45 and 0.66μmol g^(-1)h^(-1)for CO and CH_(4),which were higher than those for g-C_(3)N_(4)and Cu-CuO_(x),respectively.This photocatalytic CO_(2)RR performance is attributed to the ultrafast switching of“Cu^(x+)−Cu^(0)”and e_(CB^(−))/h_(VB^(+))trapping transformation in Cu-CuO_(x)benefited from the built-in IEF between Cu-CuO_(x)and g-C_(3)N_(4),increasing the efficient photogenerated e_(CB^(−)),and enabling the stability of Cu-CuO_(x)/g-C_(3)N_(4).Cu^(x+)adsorbed by H_(2)O works as the electron trapping site to change to Cu^(0)and switch to the hole trapping site;Cu^(0)works as the hole trapping site to change to Cu^(x+)and switch to the electron trapping site,causing the CO_(2)RR of the adsorbed CO_(2).Moreover,the coordinated Cu^(0)and Cu^(+)species facilitate the activation of the adsorbed CO_(2)and^(∗)CO generation,these adsorbed^(∗)CO on Cu^(0)and Cu^(+)detected by in-situ DRIFTS quickly transformed to^(∗)CHO with a lower energy barrier benefited from the mixed Cu^(0)/Cu^(+)active sites during CORR to produce CH_(4).This finding provides a new insight into the influence of mixed valence Cu during photocatalytic CO_(2)RR.展开更多
Tajikistan contains the majority of Central Asia’s glaciers,which cover about 6.00%of the national territory;their rapid shrinkage poses a significant threat to regional water resource security.However,glacier monito...Tajikistan contains the majority of Central Asia’s glaciers,which cover about 6.00%of the national territory;their rapid shrinkage poses a significant threat to regional water resource security.However,glacier monitoring in Tajikistan was interrupted after 1991,creating a substantial gap in understanding the current state and temporal evolution of these glaciers.Based on glacier inventory data,in situ measurements,and published literature,this study examined the present status and recent variations of glaciers in Tajikistan through data integration and validation,literature collation and comparative analysis,and the application of Geographic Information System(GIS)spatial analysis techniques.As of 2023,Tajikistan possesses a total of 11,528 glaciers,encompassing an area of 7624.48(±305.58)km2.Small glaciers dominate in number,whereas large glaciers account for the majority of the total area.Over the past two decades,the glacier count has decreased by 2014,and the total area has decreased by 628.98 km2,corresponding to an average annual reduction rate of 0.33%.Regional shrinkage rates range from 4.10%to 22.28%.Glaciers have undergone accelerated mass loss during the past 20 a;only those on the northeastern Pamir Plateau exhibit a weak positive mass balance.Observations of typical monitored glaciers also reveal intensified melting and retreat,consistent with regional trends.In light of the recent acceleration of glacier shrinkage in Tajikistan,focused measures should be implemented to strengthen glacier monitoring,enhance public awareness of glacier preservation,and promote the sustainable development and utilization of glacier tourism.These findings bridge the knowledge gap regarding the spatiotemporal dynamics of Tajikistan’s glaciers over recent decades and provide essential data support for regional water resource management.展开更多
Alcoholic liver disease(ALD) is a major cause of acute and chronic liver injury. Extensive evidence has been accumulated on the pathological process of ALD during the past decades. However, effective treatment options...Alcoholic liver disease(ALD) is a major cause of acute and chronic liver injury. Extensive evidence has been accumulated on the pathological process of ALD during the past decades. However, effective treatment options for ALD are very limited due to the lack of suitable in vivo models that recapitulate the full spectrum of ALD. Experimental animal models of ALD, particularly rodents, have been used extensively to mimic human ALD. An ideal animal model should recapitulate all aspects of the ALD process, including significant steatosis, hepatic neutrophil infiltration, and liver injury. A better strategy against ALD depends on clear diagnostic biomarkers, accurate predictor(s) of its progression and new therapeutic approaches to modulate stop or even reverse the disease. Numerous models employing rodent animals have been established in the last decades to investigate the effects of acute and chronic alcohol exposure on the initiation and progression of ALD. Although significant progress has been made in gaining better knowledge on the mechanisms and pathology of ALD, many features of ALD are unknown, and require further investigation, ideally with improved animal models that more effectively mimic human ALD. Although differences in the degree and stages of alcoholic liver injury inevitably exist between animal models and human ALD, the acquisition and translational relevance will be greatly enhanced with the development of new and improved animal models of ALD.展开更多
Iodine containing disinfection by-products（I-DBPs） and haloacetaldehydes（HALs） are emerging disinfection by-product（DBP） classes of concern. The former due to its increased potential toxicity and the latter beca...Iodine containing disinfection by-products（I-DBPs） and haloacetaldehydes（HALs） are emerging disinfection by-product（DBP） classes of concern. The former due to its increased potential toxicity and the latter because it was found to be the third most relevant DBP class in mass in a U.S. nationwide drinking water study. These DBP classes have been scarcely investigated, and this work was performed to further explore their formation in drinking water under chlorination and chloramination scenarios. In order to do this, iodo-trihalomethanes（I-THMs）,iodo-haloacetic acids（I-HAAs） and selected HALs（mono-HALs and di-HALs species, including iodoacetaldehyde） were investigated in DBP mixtures generated after chlorination and chloramination of different water matrices containing different levels of bromide and iodide in laboratory controlled reactions. Results confirmed the enhancement of I-DBP formation in the presence of monochloramine. While I-THMs and I-HAAs contributed almost equally to total I-DBP concentrations in chlorinated water, I-THMs contributed the most to total I-DBP levels in the case of chloraminated water. The most abundant and common I-THM species generated were bromochloroiodomethane, dichloroiodomethane, and chlorodiiodomethane. Iodoacetic acid and chloroiodoacetic acid contributed the most to the total I-HAA concentrations measured in the investigated disinfected water. As for the studied HALs, dihalogenated species were the compounds that predominantly formed under both investigated treatments.展开更多
To elucidate the physiology underlying the development of superficial scald in pears,susceptible“Blanquilla”fruit was treated with different compounds that either promoted(ethylene)or repressed(1-methylcyclopropene ...To elucidate the physiology underlying the development of superficial scald in pears,susceptible“Blanquilla”fruit was treated with different compounds that either promoted(ethylene)or repressed(1-methylcyclopropene and lovastatin)the incidence of this disorder after 4 months of cold storage.Our data show that scald was negligible for the fruit treated with 1-methylcyclopropene or lovastatin,but highly manifested in untreated(78%incidence)or ethylenetreated fruit(97%incidence).The comparison between the fruit metabolomic profile and transcriptome evidenced a distinct reprogramming associated with each treatment.In all treated samples,cold storage led to an activation of a cold-acclimation-resistance mechanism,including the biosynthesis of very-long-chain fatty acids,which was especially evident in 1-methylcyclopropane-treated fruit.Among the treatments applied,only 1-methylcyclopropene inhibited ethylene production,hence supporting the involvement of this hormone in the development of scald.However,a common repression effect on the PPO gene combined with higher sorbitol content was found for both lovastatin and 1-methylcyclopropene-treated samples,suggesting also a non-ethylene-mediated process preventing the development of this disorder.The results presented in this work represent a step forward to better understand the physiological mechanisms governing the etiology of superficial scald in pears.展开更多
The North-East region of Mexican Republic has a semi-arid weather condition;this area covers partially Tamaulipas, Nuevo León and Coahuila states. Pablillo River Basin (PRB) is located close to Nuevo León so...The North-East region of Mexican Republic has a semi-arid weather condition;this area covers partially Tamaulipas, Nuevo León and Coahuila states. Pablillo River Basin (PRB) is located close to Nuevo León south border and its catchment area involves Linares City (LC), Hualahuises City (HC) and Cerro-Prieto dam (CP). This reservoir captures drinking water to Monterrey Metropolitan Zone (MMZ) the major urban center on the north-east Mexican region. More than 50% of the potable water for LC comes from groundwater stockpiles. A combination of GIS maps and major ion chemistry analysis has been assessed, to know the origin, geochemical evolution, and hydraulic interconnection of groundwater. During 2008-2009, 46 groundwater samples were taken and analyzed around LC and HC. GIS technology was use to analyze the spatial distribution of the constituents of groundwater through thematic maps. The major ion analysis and its results suggest the presences of two aquifers;shallow porous aquifer on the top and fractured aquifer on the bottom. General water mineralization was discovered, including dissolution of halite, dolomites and carbonates through the aquifers. Water quality varies widely through the aquifers, and the general pathways go from southwest to northeast direction. The overexploitation of groundwater increases the water mixing of groundwater between shallow and deeper aquifers. Natural origin of groundwater and groundwater pollution by anthropogenic activities should be considered in the groundwater quality analysis for drinking water purpose.展开更多
Colorectal cancer(CRC)is one of the most frequent neoplasms and an important cause of mortality in the developed world.This cancer is caused by both genetic and environmental factors although 35%of the variation in CR...Colorectal cancer(CRC)is one of the most frequent neoplasms and an important cause of mortality in the developed world.This cancer is caused by both genetic and environmental factors although 35%of the variation in CRC susceptibility involves inherited genetic differences.Mendelian syndromes account for about5%of the total burden of CRC,with Lynch syndrome and familial adenomatous polyposis the most common forms.Excluding hereditary forms,there is an important fraction of CRC cases that present familial aggregation for the disease with an unknown germline genetic cause.CRC can be also considered as a complex disease taking into account the common diseasecommom variant hypothesis with a polygenic model of inheritance where the genetic components of common complex diseases correspond mostly to variants of low/moderate effect.So far,30 common,low-penetrance susceptibility variants have been identified for CRC.Recently,new sequencing technologies including exomeand whole-genome sequencing have permitted to add a new approach to facilitate the identification of new genes responsible for human disease predisposition.By using whole-genome sequencing,germline mutations in the POLE and POLD1 genes have been found to be responsible for a new form of CRC genetic predisposition called polymerase proofreading-associated polyposis.展开更多
<strong>Background and objective:</strong> Nasal obstruction is the most frequent presentation to the otolaryngologist all over the world. Symptoms are multisystem involvement such as headache, epistaxis, ...<strong>Background and objective:</strong> Nasal obstruction is the most frequent presentation to the otolaryngologist all over the world. Symptoms are multisystem involvement such as headache, epistaxis, ophthalmological, otological, upper and lower respiratory tract infections;and many more. Septoplasty is commonly performed for nasal septal deviation as a primary indication of nasal airway obstruction. Physical examination, anterior rhinoscopy and nasal endoscopy are considered the gold standard for detecting septal deviation. Computed tomography (CT) can also be used to evaluate the nasal septum, anatomical variants and unveils the associated sinonasal diseases. This study aimed to find out the advantages of CT in endoscopic septoplasty for all out benefits to the patients. <strong>Patients and methods:</strong> 168 patients of nasal septal deviation were selected from 2015 to 2018 in the Bangladesh Medical and Popular Medical College Specialized Hospital. Age ranged between 10 years to 70 years of age. CT scanning in both coronal, axial and sagittal sections had been done in all patients after proper history taking, physical examination, anterior rhinoscopy and nasal endoscopy. Endoscopic septoplasty alone and/or other ancillary procedures were performed in all 168 patients under general anesthesia. <strong>Results:</strong> Amongst 168 patients, male was 116 (69%) and female was 52 (31%) with a ratio 2.2:1. Maximum 58 (35%) reported in 31 to 40 years and 48 (29%) was found in 21 to 31 years of age. Hypertrophied inferior turbinate (HIT) 54 (32%) and 48 (29%) concha bullosa (CB) were associated with 168 septal deviation. Associated pathologies like maxillary antral cyst 68 (40%) and maxillary sinusitis 62 (37%) were documented. <strong>Conclusion:</strong> CT scanning unveils the abnormal anatomic variants and associated sinonasal pathologies along with nasal septal deviation. Endoscopic septoplasty, correction of the anatomical variants and complete surgical clearance of the sinonasal pathologies can give the patient a grand success.展开更多
Arctic climate changes have profoundly influenced the polar environmental changes in recent years.The Arctic Oscillation(AO),as a key component of the Arctic climate system’s internal variability,affects the source t...Arctic climate changes have profoundly influenced the polar environmental changes in recent years.The Arctic Oscillation(AO),as a key component of the Arctic climate system’s internal variability,affects the source to sink processes and interactions across the multilayer Arctic system by regulating the land,ocean,sea ice,and atmospheric processes.The East Siberian Arctic Shelf(ESAS)has experienced significant changes in the input,transport,and burial of sedimentary organic carbon(OC)due to climate warming and shifts in the AO phase in recent decades.This study analyzes grain size,total organic carbon(TOC),total nitrogen(TN),and stable carbon isotope(δ^(13)C)in two sediment cores from the ESAS to reconstruct the burial record of OC over the past few decades and examine the response mechanism of sedimentary OC records to regional-scale climate forcing.The results show that the OC in the two sediment cores originates from mixed sources with a dominant terrestrial contribution.In the LV83-28 core from the Laptev Sea,the TOC and TN contents have increased at an accelerated rate since the 1990s,with a noticeable rise in the contribution of terrestrial OC.This trend is linked to an increase in terrigenous input caused by the positive AO phase.Core LV83-39 in the East Siberian Sea could have accumulated more terrestrial OC transported along the continental shelf during the positive AO.This implies that,under the interannual regulation of the AO regime,the input and crossshelf transport of terrigenous OC in the ESAS showed consistent sedimentary responses.This finding could enhance the understanding of the burial mechanism of sedimentary OC and its environmental response to regional climate change.展开更多
After the approval of the International Classification of Functioning,Disability and Health(ICF)[1] and a worldwide ranging exploration of the use of the ICF in rehabilitation and health services provision in cooperat...After the approval of the International Classification of Functioning,Disability and Health(ICF)[1] and a worldwide ranging exploration of the use of the ICF in rehabilitation and health services provision in cooperation with WHO and ISPRM[2],it is now time for a system-wide implementation[3-7].The approval of the ICF in展开更多
WHO-FIC-FDRG专家委员会Stucki博士于2008年5月13日访问了中国康复研究中心康复信息研究所,并与WHO-FIC-FDRG专家邱卓英博士及其同事做了广泛交流。Stucki博士就ICF应用于康复科学体系建设以及开发基于ICF核心分类模板相关事宜做了专题...WHO-FIC-FDRG专家委员会Stucki博士于2008年5月13日访问了中国康复研究中心康复信息研究所,并与WHO-FIC-FDRG专家邱卓英博士及其同事做了广泛交流。Stucki博士就ICF应用于康复科学体系建设以及开发基于ICF核心分类模板相关事宜做了专题讲座。作为《Journal of Rehabilitation Medicine》杂志编委,Stucki博士欣然接受本刊邀请成为本刊的国际编委,并代表德国国际分类家族WHO合作中心—ICF研究分中心(ICF Research Branch of WHO Collaborating Center for the Family of International Classifications,Germany(DMIDI))与中国康复信息研究所建立有关ICF研究国际合作,建立了《Journal of Rehabilitation Medicine》和《中国康复理论与实践》杂志间的学术联系。本专题的英文文章发表于《Journal of Rehabilitation Medicine》,由Stucki教授授权《中国康复理论与实践》杂志以中文形式独家发表。第一篇是由中外专家专门为本刊撰写的特稿。本专题的文章是在相关专家组织下翻译的,内容涉及基于ICF的康复学科体系的建立,面向功能的整合性康复学科体系的发展,从细胞到社会的功能结构分类摸板,基于ICF重新定义康复医学、康复科学和康复服务,以及开发应用于不同康复医疗领域的ICF核心分类等内容。这些研究反应了国际最新的理论和应用发展成果,对于依据ICF这一国际性的功能残疾模式和知识分类标准,建立符合科学发展规律和社会发展要求的学科体系以及实践领域具有十分重要的理论和实践意义。通过出版本专题,希望能使广大康复科技工作者关注国际相关发展,更新有关观念和方法,推动康复科学学科建设和发展,扩大国际合作与交流。鉴于ICF理论与方法相对较新,本专题中很多文章从科学学和方法论角度探讨学科建设和知识体系的构建,有的内容涉及到专业性很强的测量学方法,这些对于专题译校团队的专家学者也是一种挑战。作为当前国际康复界研究发展的热点领域,文章作者、译校者也衷心希望专家和读者就有关问题开展广泛讨论,促进残疾和康复科学发展。本研究相关研究是国家科技部科技基础性工作和社会公益研究专项项目:中国残疾分类系统和评定标准平台研究(2003DIB1J063);国家科技部科技基础性工作和社会公益研究专项项目:中国残疾人功能和健康评定研究(2004DIB5J183)和首都医学发展科研基金:基于ICF架构的功能、残疾和健康评定和研究(2007-3132)支持研究项目。展开更多
In order to diagnose the common faults of railway switch control circuit,a fault diagnosis method based on density-based spatial clustering of applications with noise(DBSCAN)and self-organizing feature map(SOM)is prop...In order to diagnose the common faults of railway switch control circuit,a fault diagnosis method based on density-based spatial clustering of applications with noise(DBSCAN)and self-organizing feature map(SOM)is proposed.Firstly,the three-phase current curve of the switch machine recorded by the micro-computer monitoring system is dealt with segmentally and then the feature parameters of the three-phase current are calculated according to the action principle of the switch machine.Due to the high dimension of initial features,the DBSCAN algorithm is used to separate the sensitive features of fault diagnosis and construct the diagnostic sensitive feature set.Then,the particle swarm optimization(PSO)algorithm is used to adjust the weight of SOM network to modify the rules to avoid“dead neurons”.Finally,the PSO-SOM network fault classifier is designed to complete the classification and diagnosis of the samples to be tested.The experimental results show that this method can judge the fault mode of switch control circuit with less training samples,and the accuracy of fault diagnosis is higher than that of traditional SOM network.展开更多
基金support of the National Natu-ral Science Foundation of China(No.62004143,22476058,and 22076052)the Key R&D Program of Hubei Province(No.2022BAA084).
文摘Cu metal and its oxides have attracted much attention for photocatalytic CO_(2)reduction reaction(CO_(2)RR),but the stability and effects of Cu oxidation states on CO_(2)RR are not fully understood.Cu^(x+)/Cu^(0)-loaded graphitic carbon nitride(g-C_(3)N_(4))heterojunctions(Cu-CuO_(x)/g-C_(3)N_(4))are fabricated via a stepwise calcination method for efficient photocatalytic CO_(2)RR.Cu_(2)O is the main component of Cu-CuO_(x)and the mixed valence Cu includes Cu^(0),Cu^(+),and Cu^(2+),which play the role of charge trapping sites and redox catalytic centers during the photocatalytic CO_(2)RR process.The main products were CO and CH_(4)for the CO_(2)RR with production rates of 14.45 and 0.66μmol g^(-1)h^(-1)for CO and CH_(4),which were higher than those for g-C_(3)N_(4)and Cu-CuO_(x),respectively.This photocatalytic CO_(2)RR performance is attributed to the ultrafast switching of“Cu^(x+)−Cu^(0)”and e_(CB^(−))/h_(VB^(+))trapping transformation in Cu-CuO_(x)benefited from the built-in IEF between Cu-CuO_(x)and g-C_(3)N_(4),increasing the efficient photogenerated e_(CB^(−)),and enabling the stability of Cu-CuO_(x)/g-C_(3)N_(4).Cu^(x+)adsorbed by H_(2)O works as the electron trapping site to change to Cu^(0)and switch to the hole trapping site;Cu^(0)works as the hole trapping site to change to Cu^(x+)and switch to the electron trapping site,causing the CO_(2)RR of the adsorbed CO_(2).Moreover,the coordinated Cu^(0)and Cu^(+)species facilitate the activation of the adsorbed CO_(2)and^(∗)CO generation,these adsorbed^(∗)CO on Cu^(0)and Cu^(+)detected by in-situ DRIFTS quickly transformed to^(∗)CHO with a lower energy barrier benefited from the mixed Cu^(0)/Cu^(+)active sites during CORR to produce CH_(4).This finding provides a new insight into the influence of mixed valence Cu during photocatalytic CO_(2)RR.
基金supported by the National Key R&D Plan“Inter-governmental International Science&Technology Innovation Cooperation”Key Specialized Program,China(2025YFE0102800)the Program of the State Key Laboratory of Cryospheric Science and Frozen Soil Engineering,Chinese Academy of Sciences(CSFSE-ZZ-2403).
文摘Tajikistan contains the majority of Central Asia’s glaciers,which cover about 6.00%of the national territory;their rapid shrinkage poses a significant threat to regional water resource security.However,glacier monitoring in Tajikistan was interrupted after 1991,creating a substantial gap in understanding the current state and temporal evolution of these glaciers.Based on glacier inventory data,in situ measurements,and published literature,this study examined the present status and recent variations of glaciers in Tajikistan through data integration and validation,literature collation and comparative analysis,and the application of Geographic Information System(GIS)spatial analysis techniques.As of 2023,Tajikistan possesses a total of 11,528 glaciers,encompassing an area of 7624.48(±305.58)km2.Small glaciers dominate in number,whereas large glaciers account for the majority of the total area.Over the past two decades,the glacier count has decreased by 2014,and the total area has decreased by 628.98 km2,corresponding to an average annual reduction rate of 0.33%.Regional shrinkage rates range from 4.10%to 22.28%.Glaciers have undergone accelerated mass loss during the past 20 a;only those on the northeastern Pamir Plateau exhibit a weak positive mass balance.Observations of typical monitored glaciers also reveal intensified melting and retreat,consistent with regional trends.In light of the recent acceleration of glacier shrinkage in Tajikistan,focused measures should be implemented to strengthen glacier monitoring,enhance public awareness of glacier preservation,and promote the sustainable development and utilization of glacier tourism.These findings bridge the knowledge gap regarding the spatiotemporal dynamics of Tajikistan’s glaciers over recent decades and provide essential data support for regional water resource management.
基金the MINECO Retos,No.SAF2016-78711 and SAF2017-87919REXOHEP-CM,No.S2017/BMD-3727+8 种基金the AMMF Cholangiocarcinoma Charity,No.2018/117the COST Action,No.CA17112Ramón y Cajal,No.RYC-2014-15242 and No.RYC-2015-17438grant of ERAB,No.EA 14/18Gilead Liver Research Scholar 2018,No.44/2018Ministerio de Sanidad,Servicios Sociales e Igualdad,No.2017I065the UCM group “Lymphocyte Immunobiology”,No.920631(imas12-associated,Ref.IBL-6)German Research Foundation(SFB/TRR57/P04 and DFG NE 2128/2-1)Interdisciplinary Center for Clinical Research from the Faculty of Medicine at RWTH Aachen University(IZKF/E8-2)
文摘Alcoholic liver disease(ALD) is a major cause of acute and chronic liver injury. Extensive evidence has been accumulated on the pathological process of ALD during the past decades. However, effective treatment options for ALD are very limited due to the lack of suitable in vivo models that recapitulate the full spectrum of ALD. Experimental animal models of ALD, particularly rodents, have been used extensively to mimic human ALD. An ideal animal model should recapitulate all aspects of the ALD process, including significant steatosis, hepatic neutrophil infiltration, and liver injury. A better strategy against ALD depends on clear diagnostic biomarkers, accurate predictor(s) of its progression and new therapeutic approaches to modulate stop or even reverse the disease. Numerous models employing rodent animals have been established in the last decades to investigate the effects of acute and chronic alcohol exposure on the initiation and progression of ALD. Although significant progress has been made in gaining better knowledge on the mechanisms and pathology of ALD, many features of ALD are unknown, and require further investigation, ideally with improved animal models that more effectively mimic human ALD. Although differences in the degree and stages of alcoholic liver injury inevitably exist between animal models and human ALD, the acquisition and translational relevance will be greatly enhanced with the development of new and improved animal models of ALD.
基金support from the European Union 7th R&D Framework Programme (FP7/2007-2013) under grant agreement 274379 (Marie Curie IOF)the COFUND Programme of the Marie Curie Actions of the EU's FP7 (2014 BP_B00064)financially supported by the Government of Catalonia (Consolidated Research Groups 2014 SGR 418-Water and Soil Quality Unit and 2014 SGR 291-ICRA)
文摘Iodine containing disinfection by-products（I-DBPs） and haloacetaldehydes（HALs） are emerging disinfection by-product（DBP） classes of concern. The former due to its increased potential toxicity and the latter because it was found to be the third most relevant DBP class in mass in a U.S. nationwide drinking water study. These DBP classes have been scarcely investigated, and this work was performed to further explore their formation in drinking water under chlorination and chloramination scenarios. In order to do this, iodo-trihalomethanes（I-THMs）,iodo-haloacetic acids（I-HAAs） and selected HALs（mono-HALs and di-HALs species, including iodoacetaldehyde） were investigated in DBP mixtures generated after chlorination and chloramination of different water matrices containing different levels of bromide and iodide in laboratory controlled reactions. Results confirmed the enhancement of I-DBP formation in the presence of monochloramine. While I-THMs and I-HAAs contributed almost equally to total I-DBP concentrations in chlorinated water, I-THMs contributed the most to total I-DBP levels in the case of chloraminated water. The most abundant and common I-THM species generated were bromochloroiodomethane, dichloroiodomethane, and chlorodiiodomethane. Iodoacetic acid and chloroiodoacetic acid contributed the most to the total I-HAA concentrations measured in the investigated disinfected water. As for the studied HALs, dihalogenated species were the compounds that predominantly formed under both investigated treatments.
基金supported by the CERCA program from the Generalitat de Catalunya and by the Ministerio de Economía y Competitividad(MINECOgrant AGL2017-87923-R).J.G.B.was the recipient of a JoséCastillejo Mobility Fellowship(CAS18/00186).
文摘To elucidate the physiology underlying the development of superficial scald in pears,susceptible“Blanquilla”fruit was treated with different compounds that either promoted(ethylene)or repressed(1-methylcyclopropene and lovastatin)the incidence of this disorder after 4 months of cold storage.Our data show that scald was negligible for the fruit treated with 1-methylcyclopropene or lovastatin,but highly manifested in untreated(78%incidence)or ethylenetreated fruit(97%incidence).The comparison between the fruit metabolomic profile and transcriptome evidenced a distinct reprogramming associated with each treatment.In all treated samples,cold storage led to an activation of a cold-acclimation-resistance mechanism,including the biosynthesis of very-long-chain fatty acids,which was especially evident in 1-methylcyclopropane-treated fruit.Among the treatments applied,only 1-methylcyclopropene inhibited ethylene production,hence supporting the involvement of this hormone in the development of scald.However,a common repression effect on the PPO gene combined with higher sorbitol content was found for both lovastatin and 1-methylcyclopropene-treated samples,suggesting also a non-ethylene-mediated process preventing the development of this disorder.The results presented in this work represent a step forward to better understand the physiological mechanisms governing the etiology of superficial scald in pears.
文摘The North-East region of Mexican Republic has a semi-arid weather condition;this area covers partially Tamaulipas, Nuevo León and Coahuila states. Pablillo River Basin (PRB) is located close to Nuevo León south border and its catchment area involves Linares City (LC), Hualahuises City (HC) and Cerro-Prieto dam (CP). This reservoir captures drinking water to Monterrey Metropolitan Zone (MMZ) the major urban center on the north-east Mexican region. More than 50% of the potable water for LC comes from groundwater stockpiles. A combination of GIS maps and major ion chemistry analysis has been assessed, to know the origin, geochemical evolution, and hydraulic interconnection of groundwater. During 2008-2009, 46 groundwater samples were taken and analyzed around LC and HC. GIS technology was use to analyze the spatial distribution of the constituents of groundwater through thematic maps. The major ion analysis and its results suggest the presences of two aquifers;shallow porous aquifer on the top and fractured aquifer on the bottom. General water mineralization was discovered, including dissolution of halite, dolomites and carbonates through the aquifers. Water quality varies widely through the aquifers, and the general pathways go from southwest to northeast direction. The overexploitation of groundwater increases the water mixing of groundwater between shallow and deeper aquifers. Natural origin of groundwater and groundwater pollution by anthropogenic activities should be considered in the groundwater quality analysis for drinking water purpose.
基金Supported by SCB is supported by a contract from the Fondo de Investigación Sanitaria,No.CP 03-0070CEJ and JM are supported by a contract from CIBERehd+7 种基金CIBERehd and CIB-ERER are funded by the Instituto de Salud Carlos IIIFondo de Investigación Sanitaria/FEDER,No.11/00219 and No.11/00681Instituto de Salud Carlos III(Acción Transversal de Cáncer),Xunta de Galicia,No.07PXIB9101209PRMinisterio de Cien-cia e Innovación,No.SAF2010-19273Asociación Espaola contra el Cáncer(Fundación Científica GCB13131592CAST y Junta de Barcelona)FundacióOlga Torres(SCB and CRP)FP7 CHIBCHA Consortium(SCB and ACar)COST Action BM1206(SCB and CRP)
文摘Colorectal cancer(CRC)is one of the most frequent neoplasms and an important cause of mortality in the developed world.This cancer is caused by both genetic and environmental factors although 35%of the variation in CRC susceptibility involves inherited genetic differences.Mendelian syndromes account for about5%of the total burden of CRC,with Lynch syndrome and familial adenomatous polyposis the most common forms.Excluding hereditary forms,there is an important fraction of CRC cases that present familial aggregation for the disease with an unknown germline genetic cause.CRC can be also considered as a complex disease taking into account the common diseasecommom variant hypothesis with a polygenic model of inheritance where the genetic components of common complex diseases correspond mostly to variants of low/moderate effect.So far,30 common,low-penetrance susceptibility variants have been identified for CRC.Recently,new sequencing technologies including exomeand whole-genome sequencing have permitted to add a new approach to facilitate the identification of new genes responsible for human disease predisposition.By using whole-genome sequencing,germline mutations in the POLE and POLD1 genes have been found to be responsible for a new form of CRC genetic predisposition called polymerase proofreading-associated polyposis.
文摘<strong>Background and objective:</strong> Nasal obstruction is the most frequent presentation to the otolaryngologist all over the world. Symptoms are multisystem involvement such as headache, epistaxis, ophthalmological, otological, upper and lower respiratory tract infections;and many more. Septoplasty is commonly performed for nasal septal deviation as a primary indication of nasal airway obstruction. Physical examination, anterior rhinoscopy and nasal endoscopy are considered the gold standard for detecting septal deviation. Computed tomography (CT) can also be used to evaluate the nasal septum, anatomical variants and unveils the associated sinonasal diseases. This study aimed to find out the advantages of CT in endoscopic septoplasty for all out benefits to the patients. <strong>Patients and methods:</strong> 168 patients of nasal septal deviation were selected from 2015 to 2018 in the Bangladesh Medical and Popular Medical College Specialized Hospital. Age ranged between 10 years to 70 years of age. CT scanning in both coronal, axial and sagittal sections had been done in all patients after proper history taking, physical examination, anterior rhinoscopy and nasal endoscopy. Endoscopic septoplasty alone and/or other ancillary procedures were performed in all 168 patients under general anesthesia. <strong>Results:</strong> Amongst 168 patients, male was 116 (69%) and female was 52 (31%) with a ratio 2.2:1. Maximum 58 (35%) reported in 31 to 40 years and 48 (29%) was found in 21 to 31 years of age. Hypertrophied inferior turbinate (HIT) 54 (32%) and 48 (29%) concha bullosa (CB) were associated with 168 septal deviation. Associated pathologies like maxillary antral cyst 68 (40%) and maxillary sinusitis 62 (37%) were documented. <strong>Conclusion:</strong> CT scanning unveils the abnormal anatomic variants and associated sinonasal pathologies along with nasal septal deviation. Endoscopic septoplasty, correction of the anatomical variants and complete surgical clearance of the sinonasal pathologies can give the patient a grand success.
基金The National Natural Science Foundation of China under contract Nos 42130412 and 42376068the Fundamental Research Funds for the Central Universities under contract No.202241001+2 种基金the Ocean Negative Carbon Emissions Program and the Taishan Scholar Program under contract No.TSQN20182117the Russian Scientific Foundation under contract No.21-77-30001the Ministry of Science and Higher Education of the Russian Federation under contract Nos 124022100083-1 and 124022100084-8.
文摘Arctic climate changes have profoundly influenced the polar environmental changes in recent years.The Arctic Oscillation(AO),as a key component of the Arctic climate system’s internal variability,affects the source to sink processes and interactions across the multilayer Arctic system by regulating the land,ocean,sea ice,and atmospheric processes.The East Siberian Arctic Shelf(ESAS)has experienced significant changes in the input,transport,and burial of sedimentary organic carbon(OC)due to climate warming and shifts in the AO phase in recent decades.This study analyzes grain size,total organic carbon(TOC),total nitrogen(TN),and stable carbon isotope(δ^(13)C)in two sediment cores from the ESAS to reconstruct the burial record of OC over the past few decades and examine the response mechanism of sedimentary OC records to regional-scale climate forcing.The results show that the OC in the two sediment cores originates from mixed sources with a dominant terrestrial contribution.In the LV83-28 core from the Laptev Sea,the TOC and TN contents have increased at an accelerated rate since the 1990s,with a noticeable rise in the contribution of terrestrial OC.This trend is linked to an increase in terrigenous input caused by the positive AO phase.Core LV83-39 in the East Siberian Sea could have accumulated more terrestrial OC transported along the continental shelf during the positive AO.This implies that,under the interannual regulation of the AO regime,the input and crossshelf transport of terrigenous OC in the ESAS showed consistent sedimentary responses.This finding could enhance the understanding of the burial mechanism of sedimentary OC and its environmental response to regional climate change.
文摘After the approval of the International Classification of Functioning,Disability and Health(ICF)[1] and a worldwide ranging exploration of the use of the ICF in rehabilitation and health services provision in cooperation with WHO and ISPRM[2],it is now time for a system-wide implementation[3-7].The approval of the ICF in
文摘WHO-FIC-FDRG专家委员会Stucki博士于2008年5月13日访问了中国康复研究中心康复信息研究所,并与WHO-FIC-FDRG专家邱卓英博士及其同事做了广泛交流。Stucki博士就ICF应用于康复科学体系建设以及开发基于ICF核心分类模板相关事宜做了专题讲座。作为《Journal of Rehabilitation Medicine》杂志编委,Stucki博士欣然接受本刊邀请成为本刊的国际编委,并代表德国国际分类家族WHO合作中心—ICF研究分中心(ICF Research Branch of WHO Collaborating Center for the Family of International Classifications,Germany(DMIDI))与中国康复信息研究所建立有关ICF研究国际合作,建立了《Journal of Rehabilitation Medicine》和《中国康复理论与实践》杂志间的学术联系。本专题的英文文章发表于《Journal of Rehabilitation Medicine》,由Stucki教授授权《中国康复理论与实践》杂志以中文形式独家发表。第一篇是由中外专家专门为本刊撰写的特稿。本专题的文章是在相关专家组织下翻译的,内容涉及基于ICF的康复学科体系的建立,面向功能的整合性康复学科体系的发展,从细胞到社会的功能结构分类摸板,基于ICF重新定义康复医学、康复科学和康复服务,以及开发应用于不同康复医疗领域的ICF核心分类等内容。这些研究反应了国际最新的理论和应用发展成果,对于依据ICF这一国际性的功能残疾模式和知识分类标准,建立符合科学发展规律和社会发展要求的学科体系以及实践领域具有十分重要的理论和实践意义。通过出版本专题,希望能使广大康复科技工作者关注国际相关发展,更新有关观念和方法,推动康复科学学科建设和发展,扩大国际合作与交流。鉴于ICF理论与方法相对较新,本专题中很多文章从科学学和方法论角度探讨学科建设和知识体系的构建,有的内容涉及到专业性很强的测量学方法,这些对于专题译校团队的专家学者也是一种挑战。作为当前国际康复界研究发展的热点领域,文章作者、译校者也衷心希望专家和读者就有关问题开展广泛讨论,促进残疾和康复科学发展。本研究相关研究是国家科技部科技基础性工作和社会公益研究专项项目:中国残疾分类系统和评定标准平台研究(2003DIB1J063);国家科技部科技基础性工作和社会公益研究专项项目:中国残疾人功能和健康评定研究(2004DIB5J183)和首都医学发展科研基金:基于ICF架构的功能、残疾和健康评定和研究(2007-3132)支持研究项目。
基金High Education Research Project Funding(No.2018C-11)Natural Science Fund of Gansu Province(Nos.18JR3RA107,1610RJYA034)Key Research and Development Program of Gansu Province(No.17YF1WA 158)。
文摘In order to diagnose the common faults of railway switch control circuit,a fault diagnosis method based on density-based spatial clustering of applications with noise(DBSCAN)and self-organizing feature map(SOM)is proposed.Firstly,the three-phase current curve of the switch machine recorded by the micro-computer monitoring system is dealt with segmentally and then the feature parameters of the three-phase current are calculated according to the action principle of the switch machine.Due to the high dimension of initial features,the DBSCAN algorithm is used to separate the sensitive features of fault diagnosis and construct the diagnostic sensitive feature set.Then,the particle swarm optimization(PSO)algorithm is used to adjust the weight of SOM network to modify the rules to avoid“dead neurons”.Finally,the PSO-SOM network fault classifier is designed to complete the classification and diagnosis of the samples to be tested.The experimental results show that this method can judge the fault mode of switch control circuit with less training samples,and the accuracy of fault diagnosis is higher than that of traditional SOM network.
