Exploring innovative cellular architectures to achieve enhanced system capacity and good coverage has become a critical issue towards realizing the next generation of wireless communications. In this context, this pap...Exploring innovative cellular architectures to achieve enhanced system capacity and good coverage has become a critical issue towards realizing the next generation of wireless communications. In this context, this paper proposes a novel concept of Universal Intelligent Small Cell （UnISCell） for enabling the densification of the next generation of cellular networks. The proposed novel concept envisions an integrated platform of providing a strong linkage between different stakeholders such as street lighting networks, landline telephone networks and future wireless networks, and is universal in nature being independent of the operating frequency bands and traffic types. The main motivating factors for the proposed small cell concept are the need of public infrastructure re-engineering, and the recent advances in several enabling technologies. First, we highlight the main concepts of the proposed UnISCell platform. Subsequently, we present two deployment scenarios for the proposed UnISCell concept considering infrastructure sharing and service sharing as important aspects. We then describe the key future technologies for enabling the proposed UnISCell concept and present a use case example with the help of numerical results. Finally, we conclude this article by providing some interesting future recommendations.展开更多
We obtain explicit expressions for one unknown thermal coefficient (among the conductivity, mass density, specific heat and latent heat of fusion) of a semi-infinite material through the one-phase fractional Lamé...We obtain explicit expressions for one unknown thermal coefficient (among the conductivity, mass density, specific heat and latent heat of fusion) of a semi-infinite material through the one-phase fractional Lamé-Clapeyron-Stefan problem with an over-specified boundary condition on the fixed face . The partial differential equation and one of the conditions on the free boundary include a time Caputo’s fractional derivative of order . Moreover, we obtain the necessary and sufficient conditions on data in order to have a unique solution by using recent results obtained for the fractional diffusion equation exploiting the properties of the Wright and Mainardi functions, given in: 1) Roscani-Santillan Marcus, Fract. Calc. Appl. Anal., 16 (2013), 802 - 815;2) Roscani-Tarzia, Adv. Math. Sci. Appl., 24 (2014), 237 - 249 and 3) Voller, Int. J. Heat Mass Transfer, 74 (2014), 269 - 277. This work generalizes the method developed for the determination of unknown thermal coefficients for the classical Lamé-Clapeyron-Stefan problem given in Tarzia, Adv. Appl. Math., 3 (1982), 74 - 82, which is recovered by taking the limit when the order .展开更多
Access can be understood as the sum of a number of elements of the interface between patients and the health care system. This study took a comprehensive approach to the dimensions of access to medications, employing ...Access can be understood as the sum of a number of elements of the interface between patients and the health care system. This study took a comprehensive approach to the dimensions of access to medications, employing indicators to evaluate the dimensions of access to antihypertensive medications in Ceilandia, DF, Brazil. This was a cross-sectional epidemiological study, administering questionnaires during home visits. The survey covered epidemiological and socioeconomic profiles, behavioral habits and the dimensions of access to antihypertensive medications comprising physical, financial, and geographic availability and accept ability according to the hypertensive population of Ceilandia. The total sample comprised 400 individuals and the hypertensive subset numbered 140 (35%). Indicators of physical availability of medications revealed that users found it difficult to acquire their drugs on almost one third of occasions and in some cases were unable to access any of these products. The greatest barriers to access were reported by users of pharmacies belonging to the Brazilian National Health Service (SUS) and on the “People’s Pharmacies” network. More than one third of the hypertensive sample spent their own money on medications they could not find at these pharmacies. The majority of the hypertensive subsets were overweight/obese, a minority engaged in physical activity and 40% were smokers/ex-smokers. More women reduced their salt intake. Men had higher incomes, educational level, and socioeconomic status. Failure to keep the public health care system supplied has prejudiced access to essential medications for hypertension treatment, transferring the costs onto users. This population has lifestyle habits that increase the risk of exacerbation of hypertension. These results reveal a need for effective public policies to ensure access to antihypertensive medications and involve users of the health care system in changing their habits and behaviors in order to achieve adequate and lasting control of systemic arterial hypertension.展开更多
Bifidobacteria are health promoting microorganisms that can interact with drugs in the intestinal tract thus modifying the activation of immune cells and host homeostasis.To study the effect of acenocoumarol on the in...Bifidobacteria are health promoting microorganisms that can interact with drugs in the intestinal tract thus modifying the activation of immune cells and host homeostasis.To study the effect of acenocoumarol on the interaction between bifidobacteria and THP-1 cells or intestinal epithelial cells.Bifidobacterium bifidum CIDCA 5310 and B.adolescentis CIDCA 5317 were grown in MRS broth in anaerobic conditions.The experiments were done in the presence of acenocoumarol.FITC-labeled bacteria were incubated with THP1 cells differentiated with PMA(THP1-PMA),and phagocytosis and intracellular localization of bacteria were assessed by flow cytometry and confocal laser microscopy,respectively.Also,expression of macrophage surface molecules in THP1 and THP1-PMA cells was assessed by flow cytometry.By using the Caco-2 ccl20:luc reporter system innate immune response was analysed by determining luciferase expression induced by flagellin.Acenocoumarol decreased phagocytosis of bifidobacteria but intracellular routing was not modified.Also,anticoagulant reduced the expression of HLA-DR and CD64 induced by bifidobacteria in both THP1-PMA and THP1 cells.Instead,the decrease in the expression of CD206 and CD23 was dependent on differentiation status of THP1 cells.Acenocoumarol increased CCL20 expression and it was partially abrogated by strain CIDCA 5310.Presence of acenocoumarol modifies the interaction between bifidobacteria and eukaryotic cells thus suggesting that the expected modulation of immune response by probiotic foods can be different in persons under anticoagulant treatment.展开更多
文摘Exploring innovative cellular architectures to achieve enhanced system capacity and good coverage has become a critical issue towards realizing the next generation of wireless communications. In this context, this paper proposes a novel concept of Universal Intelligent Small Cell （UnISCell） for enabling the densification of the next generation of cellular networks. The proposed novel concept envisions an integrated platform of providing a strong linkage between different stakeholders such as street lighting networks, landline telephone networks and future wireless networks, and is universal in nature being independent of the operating frequency bands and traffic types. The main motivating factors for the proposed small cell concept are the need of public infrastructure re-engineering, and the recent advances in several enabling technologies. First, we highlight the main concepts of the proposed UnISCell platform. Subsequently, we present two deployment scenarios for the proposed UnISCell concept considering infrastructure sharing and service sharing as important aspects. We then describe the key future technologies for enabling the proposed UnISCell concept and present a use case example with the help of numerical results. Finally, we conclude this article by providing some interesting future recommendations.
文摘We obtain explicit expressions for one unknown thermal coefficient (among the conductivity, mass density, specific heat and latent heat of fusion) of a semi-infinite material through the one-phase fractional Lamé-Clapeyron-Stefan problem with an over-specified boundary condition on the fixed face . The partial differential equation and one of the conditions on the free boundary include a time Caputo’s fractional derivative of order . Moreover, we obtain the necessary and sufficient conditions on data in order to have a unique solution by using recent results obtained for the fractional diffusion equation exploiting the properties of the Wright and Mainardi functions, given in: 1) Roscani-Santillan Marcus, Fract. Calc. Appl. Anal., 16 (2013), 802 - 815;2) Roscani-Tarzia, Adv. Math. Sci. Appl., 24 (2014), 237 - 249 and 3) Voller, Int. J. Heat Mass Transfer, 74 (2014), 269 - 277. This work generalizes the method developed for the determination of unknown thermal coefficients for the classical Lamé-Clapeyron-Stefan problem given in Tarzia, Adv. Appl. Math., 3 (1982), 74 - 82, which is recovered by taking the limit when the order .
文摘Access can be understood as the sum of a number of elements of the interface between patients and the health care system. This study took a comprehensive approach to the dimensions of access to medications, employing indicators to evaluate the dimensions of access to antihypertensive medications in Ceilandia, DF, Brazil. This was a cross-sectional epidemiological study, administering questionnaires during home visits. The survey covered epidemiological and socioeconomic profiles, behavioral habits and the dimensions of access to antihypertensive medications comprising physical, financial, and geographic availability and accept ability according to the hypertensive population of Ceilandia. The total sample comprised 400 individuals and the hypertensive subset numbered 140 (35%). Indicators of physical availability of medications revealed that users found it difficult to acquire their drugs on almost one third of occasions and in some cases were unable to access any of these products. The greatest barriers to access were reported by users of pharmacies belonging to the Brazilian National Health Service (SUS) and on the “People’s Pharmacies” network. More than one third of the hypertensive sample spent their own money on medications they could not find at these pharmacies. The majority of the hypertensive subsets were overweight/obese, a minority engaged in physical activity and 40% were smokers/ex-smokers. More women reduced their salt intake. Men had higher incomes, educational level, and socioeconomic status. Failure to keep the public health care system supplied has prejudiced access to essential medications for hypertension treatment, transferring the costs onto users. This population has lifestyle habits that increase the risk of exacerbation of hypertension. These results reveal a need for effective public policies to ensure access to antihypertensive medications and involve users of the health care system in changing their habits and behaviors in order to achieve adequate and lasting control of systemic arterial hypertension.
文摘Bifidobacteria are health promoting microorganisms that can interact with drugs in the intestinal tract thus modifying the activation of immune cells and host homeostasis.To study the effect of acenocoumarol on the interaction between bifidobacteria and THP-1 cells or intestinal epithelial cells.Bifidobacterium bifidum CIDCA 5310 and B.adolescentis CIDCA 5317 were grown in MRS broth in anaerobic conditions.The experiments were done in the presence of acenocoumarol.FITC-labeled bacteria were incubated with THP1 cells differentiated with PMA(THP1-PMA),and phagocytosis and intracellular localization of bacteria were assessed by flow cytometry and confocal laser microscopy,respectively.Also,expression of macrophage surface molecules in THP1 and THP1-PMA cells was assessed by flow cytometry.By using the Caco-2 ccl20:luc reporter system innate immune response was analysed by determining luciferase expression induced by flagellin.Acenocoumarol decreased phagocytosis of bifidobacteria but intracellular routing was not modified.Also,anticoagulant reduced the expression of HLA-DR and CD64 induced by bifidobacteria in both THP1-PMA and THP1 cells.Instead,the decrease in the expression of CD206 and CD23 was dependent on differentiation status of THP1 cells.Acenocoumarol increased CCL20 expression and it was partially abrogated by strain CIDCA 5310.Presence of acenocoumarol modifies the interaction between bifidobacteria and eukaryotic cells thus suggesting that the expected modulation of immune response by probiotic foods can be different in persons under anticoagulant treatment.
