We studied the effects of butyric acid (BA) on mouse skin tumorigenesis using chronicanimal bioassays. Topical application of BA immediately after each treatment with 12-0-te-t radecanoyl phorbol-13-acetate (TPA) prom...We studied the effects of butyric acid (BA) on mouse skin tumorigenesis using chronicanimal bioassays. Topical application of BA immediately after each treatment with 12-0-te-t radecanoyl phorbol-13-acetate (TPA) promoter' inhi bi ted skint umors. The effect was depe n -dent on the dose of BA applied. BA showed no marked inhibitory effect on either skin tumorinitiation or complete tumorigenesis induced by dimet hyl benzant hracene (DMBA ). Si nce t u -mor promotion reportedly involves epigenetic events whereas tumor initiation or complete tu-morigenesis takes place through genetic pathways, it is Possible that BA exerts its antitumori-genic effects mainly by altering the epigenetic events responsible for tumor promotion. The re-sults of the study could further be used to study the mechanism of action and modification ofantitumorigenic effects of BA in combination with other substances展开更多
文摘We studied the effects of butyric acid (BA) on mouse skin tumorigenesis using chronicanimal bioassays. Topical application of BA immediately after each treatment with 12-0-te-t radecanoyl phorbol-13-acetate (TPA) promoter' inhi bi ted skint umors. The effect was depe n -dent on the dose of BA applied. BA showed no marked inhibitory effect on either skin tumorinitiation or complete tumorigenesis induced by dimet hyl benzant hracene (DMBA ). Si nce t u -mor promotion reportedly involves epigenetic events whereas tumor initiation or complete tu-morigenesis takes place through genetic pathways, it is Possible that BA exerts its antitumori-genic effects mainly by altering the epigenetic events responsible for tumor promotion. The re-sults of the study could further be used to study the mechanism of action and modification ofantitumorigenic effects of BA in combination with other substances
