Although the intermittent energy-driven direct seawater splitting technology provides an unparalleled approach to achieving sustainable development,the severe corrosion via aggressive Cl^(-)severely affects the stabil...Although the intermittent energy-driven direct seawater splitting technology provides an unparalleled approach to achieving sustainable development,the severe corrosion via aggressive Cl^(-)severely affects the stability and efficiency of the anode catalyst and limits its industrial application.Herein,a lattice Cl^(-)functioned NiFe-LDH electrode(E-NF-LDHCl or E-NF-LDHSW)is firstly constructed by a minute-level electrochemistry assisted chlorine corrosion strategy,which presents enhanced oxygen evolution reaction(OER)performance and excellent anti-Cl^(-)corrosion behavior for seawater splitting.The optimized E-NF-LDHCl and E-NF-LDHSW deliver low OER overpotential of 355 and 384 mV to reach 1 A cm^(-2)current density in the 1 mol L^(-1)KOH and 1 mol L^(-1)KOH seawater,respectively,as well as excellent stability of E-NF-LDHCl is maintained at 1 A cm^(-2) for 400 h in the 1 mol L^(-1)KOH and 1 mol L^(-1)KOH+0.5 mol L^(-1)NaCl.MD(molecular dynamics)simulation and DFT(density functional theory)calculation confirmed that strong common-ion repulsion effect in IHP region repels free Cl^(-),forming high spin polarization centers and more single electrons to enhance the intrinsic activity of OER.展开更多
Birch mice(family Sicistidae)are small dipodoid rodents distributed in regions surrounding the Qinghai-Xizang Plateau and extending across the Palearctic.In China,members of the genus Sicista are rarely recorded,and t...Birch mice(family Sicistidae)are small dipodoid rodents distributed in regions surrounding the Qinghai-Xizang Plateau and extending across the Palearctic.In China,members of the genus Sicista are rarely recorded,and their systematics remain poorly resolved.As part of the Second Xizang Plateau Expedition by the Kunming Institute of Zoology,Chinese Academy of Sciences,systematic surveys conducted in southern Xizang and the western Tianshan Mountains yielded two previously unrecognized species.Two specimens from southern Xizang were found to occupy a deeply divergent phylogenetic position within Sicistidae.Morphological assessments and molecular phylogenetic analyses of both extant and fossil Sicistidae,along with total-evidence dating and ancestral distribution reconstruction,identified these specimens as representatives of an ancient extant lineage that diverged from Sicista approximately 20.38 million years ago.This lineage is designated as a new genus,defined by the new species Breviforamen shannanensis gen.et sp.nov.Furthermore,11 specimens from the Tianshan Mountains are described as a second new species,Sicista brevicauda sp.nov.,based on diagnostic morphological and genetic features.Ancestral distribution reconstructions,combined with fossil records,indicate an early Miocene origin for Sicistidae across a broad region spanning the“Gobi”Desert to parts of North America.Climatic deterioration and increasing desertification during the mid-Miocene likely drove southward dispersal of Breviforamen gen.nov.into southern Xizang prior to the complete formation of the Yarlung Zangbo River.Overall,these findings broaden current understanding of Sicistidae diversity,elucidate the origin and dispersal patterns of the family,and highlight the presence of an ancient relict lineage in China.展开更多
We present the discovery of TCP J07222683+6220548,a new ultracompact binary system of the AM CVn type.This system was first identified displaying aΔV=7.6 mag outburst on 2025-01-20.9416 UTC by the New Milky Way wide-...We present the discovery of TCP J07222683+6220548,a new ultracompact binary system of the AM CVn type.This system was first identified displaying aΔV=7.6 mag outburst on 2025-01-20.9416 UTC by the New Milky Way wide-field survey for transients and later independently detected by ASAS-SN and ZTF.The outburst peaked at V_(max)=12.45 and lasted for seven days,followed by a series of rebrightenings.No previous outbursts are found in archival data.Positive superhumps with a period of 0.032546±0.000084 day(46.87±0.12 minutes),barely detectable during the main outburst,became clearly visible during the first rebrightening that lasted from day 18 to day 24 after the initial outburst.No convincing change in the superhump period was detected.Dense time-series photometry follow-up by a pair of 0.5 m INASAN robotic telescopes,together with VSNET and AAVSO observers,was essential for identifying TCP J07222683+6220548 as an AM CVn system and triggering confirmation spectroscopy with the 2.5 m CMO SAI telescope.Some outbursting AM CVn systems lacking such detailed follow-up may remain unrecognized among the newly discovered cataclysmic variable candidates.展开更多
The common characteristic criteria of all functional gastrointestinal(GI)disorders are the persistence and recurrence of variable gastrointestinal symptoms that cannot be explained by any structural or biochemical abn...The common characteristic criteria of all functional gastrointestinal(GI)disorders are the persistence and recurrence of variable gastrointestinal symptoms that cannot be explained by any structural or biochemical abnormalities. Functional dyspepsia (FD) represents one of the important GI disorders in Western countries because of its remarkably high prevalence in general population and its impact on quality of life. Due to its dependence on both subjective determinants and diverse country-specific circumstances, the definition and management strategies of FD are still variably stated.Clinical trials with several drug classes (e.g., proton pump inhibitors, H2-blockers, prokinetic drugs) have been performed frequently without validated diseasespecific test instruments for the outcome measurements.Therefore, the interpretation of such trials remains difficult and controversial with respect to comparability and evaluation of drug efficacy, and definite conclusions can be drawn neither for diagnostic management nor for efficacious drug therapy so far. In view of these unsolved problems, guidelines both on the clinical management of FD and on the performance of clinical trials are needed. In recent years, increasing research work has been done in this area. Clinical trials conducted in adequately diagnosed patients that provided validated outcome measurements may result in better insights leading to more effective treatment strategies.Encouraging perspectives have been recently performed by methodologically well-designed treatment studies with herbal drug preparations. Herbal drugs, given their proven efficacy in clinical trials, offer a safe therapeutic alternative in the treatment of FD which is often favored by both patients and physicians. A fixed combination of peppermint oil and caraway oil in patients suffering from FD could be proven effective by well-designed clinical trials.展开更多
In order to understand the key mechanisms of the composting processes, the municipal solid waste(MSW) composting processes were divided into two stages, and the characteristics of typical experimental scenarios from t...In order to understand the key mechanisms of the composting processes, the municipal solid waste(MSW) composting processes were divided into two stages, and the characteristics of typical experimental scenarios from the viewpoint of microbial kinetics was analyzed. Through experimentation with advanced composting reactor under controlled composting conditions, several equations were worked out to simulate the degradation rate of the substrate. The equations showed that the degradation rate was controlled by concentration of microbes in the first stage. The degradation rates of substrates of inoculation Run A, B, C and Control composting systems were 13 61 g/(kg·h), 13 08 g/(kg·h), 15 671 g/(kg·h), and 10 5 g/(kg·h), respectively. The value of Run C is around 1 5 times higher than that of Control system. The decomposition rate of the second stage is controlled by concentration of substrate. Although the organic matter degradation rates were similar to all Runs, inoculation could reduce the values of the half velocity coefficient K \-m and could be more efficient to make the composting stable. Particularly, for Run C, the degradation rate is high in the first stage, and K \-m is low in the second stage. The results indicated that the inoculation was efficient for the composting processes.展开更多
AIM： To study the main environmental and lifestyle factors that account for the regional differences in esophageal cancer （EC） risk in low- and high-risk areas of Jiangsu Province, China. METHODS： Since 2003, a po...AIM： To study the main environmental and lifestyle factors that account for the regional differences in esophageal cancer （EC） risk in low- and high-risk areas of Jiangsu Province, China. METHODS： Since 2003, a population-based casecontrol study has been conducted simultaneously in lowrisk （Ganyu County） and high-risk （Dafeng County） areas of Jiangsu Province, China. Using identical protocols and pre-tested standardized questionnaire, following written informed consent, eligible subjects were inquired about their detail information on potential determinants of EC, including demographic information, socio-economic status, living conditions, disease history, family cancer history, smoking, alcohol drinking, dietary habits, frequency, amount of food intake, etc. Conditional logistic regression with maximum likelihood estimation was used to obtain Odds ratio （OR） and 95 % confidence interval （95% CI）, after adjustment for potential confounders. RESULTS： In the preliminary analysis of the ongoing study, we recruited 291 pairs of cases and controls in Dafeng and 240 pairs of cases and controls in Ganyu, respectively. In both low-risk and high-risk areas, EC was inversely associated with socio-economic status, such as level of education, past economic status and body mass index. However, this disease was more frequent among those who had a family history of cancer or encountered misfortune in the past 10 years. EC was also more frequent among smokers, alcohol drinkers and fast eaters. Furthermore, there was a geographic variation of the associations between smoking, alcohol drinking and EC risk despite the similar prevalence of these risk factors in both low-risk and high-risk areas. The dose-response relationship of smoking and smoking related variables, such as age of the first smoking, duration and amount were apparent only in high-risk areas. On the contrary, a dose-response relationship on the effect of alcohol drinking on EC was observed only in low-risk areas. CONCLUSION： The environmental risk factors, together with genetic factors and gene-environmental interactions might be the main reason for this high-risk gradient in .liangsu Province, China.展开更多
Lithium nickel oxide(LiNiO_(2)) cathode materials are featured with high capacity and low cost for rechargeable lithium-ion batteries but suffer from severe interface and structure instability.Here we report that rati...Lithium nickel oxide(LiNiO_(2)) cathode materials are featured with high capacity and low cost for rechargeable lithium-ion batteries but suffer from severe interface and structure instability.Here we report that rationally designed LiNiO_(2) via concentration-gradient yttrium modification exhibits alleviative side reactions and improved electrochemical performance.The LiNiO_(2) cathode with LiYO_(2)-Y_(2) O_(3) coating layer delivers a discharge capacity of 225 mAh g^(-1) with a high initial Coulombic efficiency of 93.4%.These improvements can be attributed to the formation of in-situ modified hybrid LiYO_(2)-Y_(2 O3) coating layer,which suppresses phase transformation,electrolyte oxidation and salt dissociation due to the formation of protective cathode electrolyte interface.The results indicate promising application of concentration-gradient yttrium coating as a facile approach to stabilize nickel-rich cathode materials.展开更多
B vitamins are enzyme cofactors that play an important role in energy metabolism.The aim of this study was to elucidate whether B vitamin administration can reduce body weight(BW)gain by improving energy metabolism-re...B vitamins are enzyme cofactors that play an important role in energy metabolism.The aim of this study was to elucidate whether B vitamin administration can reduce body weight(BW)gain by improving energy metabolism-related enzyme activities in rats fed on a highfat diet.Fifty rats were randomly assigned to one of the following five groups:control group(C),including rats fed on standard rat chow;four treatment groups(H0,H1,H2,and H3),in which rats were fed on a high-fat diet.Rats in the H1 group were treated daily with 100 mg/kg BW thiamine(VB1),100 mg/kg BW riboflavin(VB2),and 250 mg/kg BW niacin(VPP);rats in the H2 group were treated daily with 100 mg/kg BW pyridoxine(VB6),100 mg/kg BW cobalamin(VB12),and 5 mg/kg BW folate(FA);and rats in the H3 group were treated daily with all of the B vitamins administered to the H1 and H2 groups.After 12 weeks,the BW gains from the initial value were 154.5±58.4 g and 159.1±53.0 g in the H1 and C groups,respectively,which were significantly less than the changes in the H0 group(285.2±14.8 g,P〈0.05).In the H0 group,the plasma total cholesterol(CHO)and triglyceride(TG)levels were 1.59±0.30 mmol/L and 1.55±0.40 mmol/L,respectively,which were significantly greater than those in the H1 group(1.19±0.18 mmol/L and 0.76±0.34 mmol/L,respectively,P〈0.05).The activities of transketolase(TK),glutathione reductase,and Na^+/K^+adenosine triphosphatase were significantly increased in the B vitamin-treated groups and were significantly greater than those in the H0 group(P〈0.05).Furthermore,the glucose-6-phosphate dehydrogenase,pyruvic acid kinase,and succinate dehydrogenase activities also were increased after treatment with B vitamins.Supplementation with B vitamins could effectively reduce BW gain and plasma levels of lipids by improving energy metabolism-related enzyme activities in rats,thus possibly providing potential benefits to humans.展开更多
文摘Although the intermittent energy-driven direct seawater splitting technology provides an unparalleled approach to achieving sustainable development,the severe corrosion via aggressive Cl^(-)severely affects the stability and efficiency of the anode catalyst and limits its industrial application.Herein,a lattice Cl^(-)functioned NiFe-LDH electrode(E-NF-LDHCl or E-NF-LDHSW)is firstly constructed by a minute-level electrochemistry assisted chlorine corrosion strategy,which presents enhanced oxygen evolution reaction(OER)performance and excellent anti-Cl^(-)corrosion behavior for seawater splitting.The optimized E-NF-LDHCl and E-NF-LDHSW deliver low OER overpotential of 355 and 384 mV to reach 1 A cm^(-2)current density in the 1 mol L^(-1)KOH and 1 mol L^(-1)KOH seawater,respectively,as well as excellent stability of E-NF-LDHCl is maintained at 1 A cm^(-2) for 400 h in the 1 mol L^(-1)KOH and 1 mol L^(-1)KOH+0.5 mol L^(-1)NaCl.MD(molecular dynamics)simulation and DFT(density functional theory)calculation confirmed that strong common-ion repulsion effect in IHP region repels free Cl^(-),forming high spin polarization centers and more single electrons to enhance the intrinsic activity of OER.
基金supported by the Second Qinghai-Xizang Plateau Scientific Expedition and Research Program(2024QZKK0200,2019QZKK05010100)Survey of Wildlife Resources in Key Areas of Xizang(ZL202203601,ZL202303601)。
文摘Birch mice(family Sicistidae)are small dipodoid rodents distributed in regions surrounding the Qinghai-Xizang Plateau and extending across the Palearctic.In China,members of the genus Sicista are rarely recorded,and their systematics remain poorly resolved.As part of the Second Xizang Plateau Expedition by the Kunming Institute of Zoology,Chinese Academy of Sciences,systematic surveys conducted in southern Xizang and the western Tianshan Mountains yielded two previously unrecognized species.Two specimens from southern Xizang were found to occupy a deeply divergent phylogenetic position within Sicistidae.Morphological assessments and molecular phylogenetic analyses of both extant and fossil Sicistidae,along with total-evidence dating and ancestral distribution reconstruction,identified these specimens as representatives of an ancient extant lineage that diverged from Sicista approximately 20.38 million years ago.This lineage is designated as a new genus,defined by the new species Breviforamen shannanensis gen.et sp.nov.Furthermore,11 specimens from the Tianshan Mountains are described as a second new species,Sicista brevicauda sp.nov.,based on diagnostic morphological and genetic features.Ancestral distribution reconstructions,combined with fossil records,indicate an early Miocene origin for Sicistidae across a broad region spanning the“Gobi”Desert to parts of North America.Climatic deterioration and increasing desertification during the mid-Miocene likely drove southward dispersal of Breviforamen gen.nov.into southern Xizang prior to the complete formation of the Yarlung Zangbo River.Overall,these findings broaden current understanding of Sicistidae diversity,elucidate the origin and dispersal patterns of the family,and highlight the presence of an ancient relict lineage in China.
基金support of the Foundation for the Development of Theoretical Physics and Mathematics BASIS(project 24-2-1-6-1)supported by the UKRI Science and Technology Facilities Council and is a collaboration between the University of Edinburgh(grant ST/N002512/1)and Queen’s University Belfast(grant ST/N002520/1)within the LSST:UK Science Consortium+4 种基金supported by the National Science Foundation under grants No.AST-1440341 and AST-2034437primarily funded to search for near earth asteroids through NASA grants NN12AR55G,80NSSC18K0284,and80NSSC18K1575partially funded by Kepler/K2 grant J1944/80NSSC19K0112 and HST GO-15889STFC grants ST/T000198/1 and ST/S006109/1made use of the Astrophysics Data System,funded by NASA under Cooperative Agreement 80NSSC21M00561。
文摘We present the discovery of TCP J07222683+6220548,a new ultracompact binary system of the AM CVn type.This system was first identified displaying aΔV=7.6 mag outburst on 2025-01-20.9416 UTC by the New Milky Way wide-field survey for transients and later independently detected by ASAS-SN and ZTF.The outburst peaked at V_(max)=12.45 and lasted for seven days,followed by a series of rebrightenings.No previous outbursts are found in archival data.Positive superhumps with a period of 0.032546±0.000084 day(46.87±0.12 minutes),barely detectable during the main outburst,became clearly visible during the first rebrightening that lasted from day 18 to day 24 after the initial outburst.No convincing change in the superhump period was detected.Dense time-series photometry follow-up by a pair of 0.5 m INASAN robotic telescopes,together with VSNET and AAVSO observers,was essential for identifying TCP J07222683+6220548 as an AM CVn system and triggering confirmation spectroscopy with the 2.5 m CMO SAI telescope.Some outbursting AM CVn systems lacking such detailed follow-up may remain unrecognized among the newly discovered cataclysmic variable candidates.
文摘The common characteristic criteria of all functional gastrointestinal(GI)disorders are the persistence and recurrence of variable gastrointestinal symptoms that cannot be explained by any structural or biochemical abnormalities. Functional dyspepsia (FD) represents one of the important GI disorders in Western countries because of its remarkably high prevalence in general population and its impact on quality of life. Due to its dependence on both subjective determinants and diverse country-specific circumstances, the definition and management strategies of FD are still variably stated.Clinical trials with several drug classes (e.g., proton pump inhibitors, H2-blockers, prokinetic drugs) have been performed frequently without validated diseasespecific test instruments for the outcome measurements.Therefore, the interpretation of such trials remains difficult and controversial with respect to comparability and evaluation of drug efficacy, and definite conclusions can be drawn neither for diagnostic management nor for efficacious drug therapy so far. In view of these unsolved problems, guidelines both on the clinical management of FD and on the performance of clinical trials are needed. In recent years, increasing research work has been done in this area. Clinical trials conducted in adequately diagnosed patients that provided validated outcome measurements may result in better insights leading to more effective treatment strategies.Encouraging perspectives have been recently performed by methodologically well-designed treatment studies with herbal drug preparations. Herbal drugs, given their proven efficacy in clinical trials, offer a safe therapeutic alternative in the treatment of FD which is often favored by both patients and physicians. A fixed combination of peppermint oil and caraway oil in patients suffering from FD could be proven effective by well-designed clinical trials.
文摘In order to understand the key mechanisms of the composting processes, the municipal solid waste(MSW) composting processes were divided into two stages, and the characteristics of typical experimental scenarios from the viewpoint of microbial kinetics was analyzed. Through experimentation with advanced composting reactor under controlled composting conditions, several equations were worked out to simulate the degradation rate of the substrate. The equations showed that the degradation rate was controlled by concentration of microbes in the first stage. The degradation rates of substrates of inoculation Run A, B, C and Control composting systems were 13 61 g/(kg·h), 13 08 g/(kg·h), 15 671 g/(kg·h), and 10 5 g/(kg·h), respectively. The value of Run C is around 1 5 times higher than that of Control system. The decomposition rate of the second stage is controlled by concentration of substrate. Although the organic matter degradation rates were similar to all Runs, inoculation could reduce the values of the half velocity coefficient K \-m and could be more efficient to make the composting stable. Particularly, for Run C, the degradation rate is high in the first stage, and K \-m is low in the second stage. The results indicated that the inoculation was efficient for the composting processes.
基金Supported by Jiangsu Provincial Health Department No. RC 2003090
文摘AIM： To study the main environmental and lifestyle factors that account for the regional differences in esophageal cancer （EC） risk in low- and high-risk areas of Jiangsu Province, China. METHODS： Since 2003, a population-based casecontrol study has been conducted simultaneously in lowrisk （Ganyu County） and high-risk （Dafeng County） areas of Jiangsu Province, China. Using identical protocols and pre-tested standardized questionnaire, following written informed consent, eligible subjects were inquired about their detail information on potential determinants of EC, including demographic information, socio-economic status, living conditions, disease history, family cancer history, smoking, alcohol drinking, dietary habits, frequency, amount of food intake, etc. Conditional logistic regression with maximum likelihood estimation was used to obtain Odds ratio （OR） and 95 % confidence interval （95% CI）, after adjustment for potential confounders. RESULTS： In the preliminary analysis of the ongoing study, we recruited 291 pairs of cases and controls in Dafeng and 240 pairs of cases and controls in Ganyu, respectively. In both low-risk and high-risk areas, EC was inversely associated with socio-economic status, such as level of education, past economic status and body mass index. However, this disease was more frequent among those who had a family history of cancer or encountered misfortune in the past 10 years. EC was also more frequent among smokers, alcohol drinkers and fast eaters. Furthermore, there was a geographic variation of the associations between smoking, alcohol drinking and EC risk despite the similar prevalence of these risk factors in both low-risk and high-risk areas. The dose-response relationship of smoking and smoking related variables, such as age of the first smoking, duration and amount were apparent only in high-risk areas. On the contrary, a dose-response relationship on the effect of alcohol drinking on EC was observed only in low-risk areas. CONCLUSION： The environmental risk factors, together with genetic factors and gene-environmental interactions might be the main reason for this high-risk gradient in .liangsu Province, China.
基金supported by the National Key R&D Program of China (2016YFA0202503)the SINOPEC Project (129015-1)+2 种基金the National Natural Science Foundation of China (21835004 and21925503)the 111 Project from the Ministry of Education of China(B12015)the Fundamental Research Funds for the Central Universities。
文摘Lithium nickel oxide(LiNiO_(2)) cathode materials are featured with high capacity and low cost for rechargeable lithium-ion batteries but suffer from severe interface and structure instability.Here we report that rationally designed LiNiO_(2) via concentration-gradient yttrium modification exhibits alleviative side reactions and improved electrochemical performance.The LiNiO_(2) cathode with LiYO_(2)-Y_(2) O_(3) coating layer delivers a discharge capacity of 225 mAh g^(-1) with a high initial Coulombic efficiency of 93.4%.These improvements can be attributed to the formation of in-situ modified hybrid LiYO_(2)-Y_(2 O3) coating layer,which suppresses phase transformation,electrolyte oxidation and salt dissociation due to the formation of protective cathode electrolyte interface.The results indicate promising application of concentration-gradient yttrium coating as a facile approach to stabilize nickel-rich cathode materials.
文摘B vitamins are enzyme cofactors that play an important role in energy metabolism.The aim of this study was to elucidate whether B vitamin administration can reduce body weight(BW)gain by improving energy metabolism-related enzyme activities in rats fed on a highfat diet.Fifty rats were randomly assigned to one of the following five groups:control group(C),including rats fed on standard rat chow;four treatment groups(H0,H1,H2,and H3),in which rats were fed on a high-fat diet.Rats in the H1 group were treated daily with 100 mg/kg BW thiamine(VB1),100 mg/kg BW riboflavin(VB2),and 250 mg/kg BW niacin(VPP);rats in the H2 group were treated daily with 100 mg/kg BW pyridoxine(VB6),100 mg/kg BW cobalamin(VB12),and 5 mg/kg BW folate(FA);and rats in the H3 group were treated daily with all of the B vitamins administered to the H1 and H2 groups.After 12 weeks,the BW gains from the initial value were 154.5±58.4 g and 159.1±53.0 g in the H1 and C groups,respectively,which were significantly less than the changes in the H0 group(285.2±14.8 g,P〈0.05).In the H0 group,the plasma total cholesterol(CHO)and triglyceride(TG)levels were 1.59±0.30 mmol/L and 1.55±0.40 mmol/L,respectively,which were significantly greater than those in the H1 group(1.19±0.18 mmol/L and 0.76±0.34 mmol/L,respectively,P〈0.05).The activities of transketolase(TK),glutathione reductase,and Na^+/K^+adenosine triphosphatase were significantly increased in the B vitamin-treated groups and were significantly greater than those in the H0 group(P〈0.05).Furthermore,the glucose-6-phosphate dehydrogenase,pyruvic acid kinase,and succinate dehydrogenase activities also were increased after treatment with B vitamins.Supplementation with B vitamins could effectively reduce BW gain and plasma levels of lipids by improving energy metabolism-related enzyme activities in rats,thus possibly providing potential benefits to humans.
