Objective: To compare the efficacy of acetaminophen, ibuprofen, and prednisone in the treatment of interferon β-1a (IFNβ-1a) flu like syndrome (FLS). Methods: Patients with relapsing remitting multiple sclerosis ini...Objective: To compare the efficacy of acetaminophen, ibuprofen, and prednisone in the treatment of interferon β-1a (IFNβ-1a) flu like syndrome (FLS). Methods: Patients with relapsing remitting multiple sclerosis initiating treatment with IM IFNβ 1a were randomized in a multicenter, randomized, double blind, controlled trial to receive acetaminophen 500 mg before and 6 and 12 hours after each injection, ibuprofen 400 mg before and 6 and 12 hours after each injection, or prednisone 60 mg daily for 1 week, plus tapering. Patients were instructed to keep a daily diary of fever severity, myalgia, chills, headache, and asthenia for 27 days. The sum of the scores of individual symptoms was used to obtain a daily FLS index. The primary outcome was the FLS index area under the curve (AUC) corrected by the number of measurement days. Results: Eighty four patients were randomized at 11 hospitals: acetaminophen (n = 28), ibuprofen (n = 28), and corticosteroids (n = 28). No differences were detected between treatments in the mean AUC of the FLS index. With limitation of the analysis to the days of IM IFNβ 1a injection, differences favoring ibuprofen were observed in the mean FLS index (p = 0.0007). Conclusions: No prophylactic treatment for flu like syndrome seems to be superior to another in terms of overall well being during the first month of IM IFNβ 1a therapy. However, ibuprofen confers better control of symptoms immediately following IM IFNβ 1a injection.展开更多
Low-carbon hydrogen is expected to play a key role in realizing net-zero and sustainable development plans.Nonetheless,there is a gap between the cost of producing low-carbon hydrogen and its potential users’willingn...Low-carbon hydrogen is expected to play a key role in realizing net-zero and sustainable development plans.Nonetheless,there is a gap between the cost of producing low-carbon hydrogen and its potential users’willingness to pay for such hydrogen.To implement support for the development of the industry,we propose using low-carbon hydrogen long-term agreements allocated through auction mechanisms.The objectives are 2-fold:(i)matching supply and demand volumes considering the time horizon and geographical delivery point specification and(ii)allocating the subsidy.This perspective article innovates by proposing a reference price indexed to liquid to natural-gas prices,which is the main product that low-carbon hydrogen aims to substitute.The premium and the production cost are defined through a double-sided auction.This aims to minimize the public policy funds required to incentivize the low-carbon hydrogen market while facilitating long-term agreements and mitigating price risks that may hinder investment.展开更多
This paper considers the eventual leader election problem in asynchronous message-passing systems where an arbitrary number t of processes can crash（t〈n,where n is the total number of processes）.It considers weak a...This paper considers the eventual leader election problem in asynchronous message-passing systems where an arbitrary number t of processes can crash（t〈n,where n is the total number of processes）.It considers weak assumptions both on the initial knowledge of the processes and on the network behavior.More precisely,initially,a process knows only its identity and the fact that the process identities are different and totally ordered（it knows neither n nor t）.Two eventual leader election protocols and a lower bound are presented.The first protocol assumes that a process also knows a lower bound α on the number of processes that do not crash.This protocol requires the following behavioral properties from the underlying network：the graph made up of the correct processes and fair lossy links is strongly connected,and there is a correct process connected to（n〈f）-α other correct processes（where f is the actual number of crashes in the considered run） through eventually timely paths（paths made up of correct processes and eventually timely links）.This protocol is not communication-efficient in the sense that each correct process has to send messages forever.The second protocol is communication-efficient：after some time,only the final common leader has to send messages forever.This protocol does not require the processes to know α,but requires stronger properties from the underlying network：each pair of correct processes has to be connected by fair lossy links（one in each direction）,and there is a correct process whose n〈f-1 output links to the rest of correct processes have to be eventually timely.A matching lower bound result shows that any eventual leader election protocol must have runs with this number of eventually timely links,even if all processes know all the processes identities.In addition to being communication-efficient,the second protocol has another noteworthy efficiency property,namely,be the run finite or infinite,all the local variables and message fields have a finite domain in the run.展开更多
文摘Objective: To compare the efficacy of acetaminophen, ibuprofen, and prednisone in the treatment of interferon β-1a (IFNβ-1a) flu like syndrome (FLS). Methods: Patients with relapsing remitting multiple sclerosis initiating treatment with IM IFNβ 1a were randomized in a multicenter, randomized, double blind, controlled trial to receive acetaminophen 500 mg before and 6 and 12 hours after each injection, ibuprofen 400 mg before and 6 and 12 hours after each injection, or prednisone 60 mg daily for 1 week, plus tapering. Patients were instructed to keep a daily diary of fever severity, myalgia, chills, headache, and asthenia for 27 days. The sum of the scores of individual symptoms was used to obtain a daily FLS index. The primary outcome was the FLS index area under the curve (AUC) corrected by the number of measurement days. Results: Eighty four patients were randomized at 11 hospitals: acetaminophen (n = 28), ibuprofen (n = 28), and corticosteroids (n = 28). No differences were detected between treatments in the mean AUC of the FLS index. With limitation of the analysis to the days of IM IFNβ 1a injection, differences favoring ibuprofen were observed in the mean FLS index (p = 0.0007). Conclusions: No prophylactic treatment for flu like syndrome seems to be superior to another in terms of overall well being during the first month of IM IFNβ 1a therapy. However, ibuprofen confers better control of symptoms immediately following IM IFNβ 1a injection.
文摘Low-carbon hydrogen is expected to play a key role in realizing net-zero and sustainable development plans.Nonetheless,there is a gap between the cost of producing low-carbon hydrogen and its potential users’willingness to pay for such hydrogen.To implement support for the development of the industry,we propose using low-carbon hydrogen long-term agreements allocated through auction mechanisms.The objectives are 2-fold:(i)matching supply and demand volumes considering the time horizon and geographical delivery point specification and(ii)allocating the subsidy.This perspective article innovates by proposing a reference price indexed to liquid to natural-gas prices,which is the main product that low-carbon hydrogen aims to substitute.The premium and the production cost are defined through a double-sided auction.This aims to minimize the public policy funds required to incentivize the low-carbon hydrogen market while facilitating long-term agreements and mitigating price risks that may hinder investment.
基金supported by the Comunidad de Madrid under Grant No.S2009/TIC-1692the Spanish MEC under Grant Nos.TIN2007-67353-C02-01 and TIN2008-06735-C02-01
文摘This paper considers the eventual leader election problem in asynchronous message-passing systems where an arbitrary number t of processes can crash（t〈n,where n is the total number of processes）.It considers weak assumptions both on the initial knowledge of the processes and on the network behavior.More precisely,initially,a process knows only its identity and the fact that the process identities are different and totally ordered（it knows neither n nor t）.Two eventual leader election protocols and a lower bound are presented.The first protocol assumes that a process also knows a lower bound α on the number of processes that do not crash.This protocol requires the following behavioral properties from the underlying network：the graph made up of the correct processes and fair lossy links is strongly connected,and there is a correct process connected to（n〈f）-α other correct processes（where f is the actual number of crashes in the considered run） through eventually timely paths（paths made up of correct processes and eventually timely links）.This protocol is not communication-efficient in the sense that each correct process has to send messages forever.The second protocol is communication-efficient：after some time,only the final common leader has to send messages forever.This protocol does not require the processes to know α,but requires stronger properties from the underlying network：each pair of correct processes has to be connected by fair lossy links（one in each direction）,and there is a correct process whose n〈f-1 output links to the rest of correct processes have to be eventually timely.A matching lower bound result shows that any eventual leader election protocol must have runs with this number of eventually timely links,even if all processes know all the processes identities.In addition to being communication-efficient,the second protocol has another noteworthy efficiency property,namely,be the run finite or infinite,all the local variables and message fields have a finite domain in the run.
