Introduction: Diabetes remains a real public health problem today, due to its associated morbidity and mortality. It induces numerous metabolic, biochemical, hematological, and immunological changes, responsible for m...Introduction: Diabetes remains a real public health problem today, due to its associated morbidity and mortality. It induces numerous metabolic, biochemical, hematological, and immunological changes, responsible for multiple complications. The objective of this study was to characterize clinically and biologically type 2 diabetic patients followed at the National Center for Diabetology and Arterial Hypertension of the Central Hospital of Yaoundé. Method: This prospective, cross-sectional, and analytical study took place from April 5 to July 31, 2023 (4 months) on 100 diabetic patients of both sexes (61 women and 39 men), aged from 31 to 88 years. Body Mass Index, systolic and diastolic blood pressure, and cardiac frequency were measured on each of the patients. Subsequently, blood was collected from the patients for the determination of the complete blood count, HBA1c, lipid profile, serum albumin, TNF-α, and IL-6 levels. The data were analyzed using SPSS 17.0 software. Results: The age average of our population was 56.99 ± 11.51 years, the population was primarily female (61%) and primarily between the ages of 55 and 88. 67% of respondents were married. 59% went to secondary school. 73% of them lived in urban areas. 30% were obese and 40% were overweight, with an average BMI of 28.75 kg/m2. 76% of patients took oral antidiabetic medications. HbA1c level average was 8.65%, with 60% having readings above 6.5%. Low hemoglobin and hypochromia were among the abnormalities of red blood cells observed. Lipid profiles revealed low HDL-cholesterol and high triglycerides and cholesterol. Elevated levels of TNF-α and IL-6 indicated inflammation and cardiovascular risk. Conclusion: These results indicate the necessity of focused diabetic care and management on diabetic patients attending the central hospital of Yaoundé, Cameroon.展开更多
Introduction: Foreign bodies (FB) in the lower airways (LAs) constitute a potentially life-threatening emergency requiring immediate management. The objective of our study was to describe the patient pathway and manag...Introduction: Foreign bodies (FB) in the lower airways (LAs) constitute a potentially life-threatening emergency requiring immediate management. The objective of our study was to describe the patient pathway and management of foreign bodies in the lower airways. Methodology: This was a descriptive study with retrospective data collection conducted over a 6-year period (January 1, 2014, to December 31, 2019) in the ENT and Head and Neck Surgery Department of Donka National Hospital. Results: We observed a prevalence of 1.79%. The average age was 5.71 years, with a sex ratio of 1.2. However, 82.61% of the cases originated from rural areas. We noted that 78.83% of patients were referred after visiting 1 to 2 healthcare facilities (75.36%). The consultation delay was 3 days. Penetration syndrome was present in 98.56% of cases. The foreign body incidents occurred during play in 54.84% and during meals in 29.09% of cases. Radiographs were performed in 93.9% of cases. Endoscopy was used for both diagnostic and therapeutic purposes in all patients. The foreign bodies were located in the trachea (37.68%), larynx (26.08%), and bronchi (21.73%). Non-organic foreign bodies were predominant (52.17%). Postoperative outcomes were uncomplicated in 95.98% of cases, and the lethality rate was 2.85%. Conclusion: The pathway of patients with foreign bodies in the airways remains unpredictable in our context due to parental hesitations. Early management reduces morbidity and mortality rates.展开更多
Objective This study aimed to investigate the effect of Astragalus(AST)on osteoporosis(OP)and the downstream mechanisms.Methods Human bone marrow-derived mesenchymal stem cells(hBMSCs)were induced to differentiate int...Objective This study aimed to investigate the effect of Astragalus(AST)on osteoporosis(OP)and the downstream mechanisms.Methods Human bone marrow-derived mesenchymal stem cells(hBMSCs)were induced to differentiate into osteogenic cells.After transfection with relevant plasmids,cell proliferation,cell cycle progression,and apoptosis were assessed.Alizarin red staining was used to detect calcium nodules in the cells,alkaline phosphatase(ALP)staining was used to detect ALP activity in the cells,and quantitative reverse transcription-polymerase chain reaction and western blotting were used to determine RUNX2 and Osterix expression levels.An OP rat model was established using ovariectomy and micro-computed tomography scanning.Hematoxylin and eosin staining and Masson’s trichrome staining were used to evaluate the pathological conditions of bone tissues,while immunohistochemistry was conducted to detect RUNX2 in bone tissues.Results AST promoted the osteogenic differentiation of BMSCs,reduced miR-181d-5p expression levels,and increased SOX11 expression levels.Restoring miR-181d-5p expression or reducing SOX11 expression levels reversed the effects of AST on the osteogenic differentiation of hBMSCs.miR-181d-5p was found to target SOX11 in hBMSCs.AST improved OP in rats,and miR-181d-5p overexpression or SOX11 inhibition reversed the therapeutic effects of AST on OP in rats.Conclusion AST promoted the osteogenic differentiation of hBMSCs and alleviated OP by targeting SOX11 via miR-181d-5p.展开更多
In this article we commented on an article published recently by Jiao et al.This retrospective study confirmed that the triple therapy of transarterial chemoembolization(TACE)combined with programmed death protein lig...In this article we commented on an article published recently by Jiao et al.This retrospective study confirmed that the triple therapy of transarterial chemoembolization(TACE)combined with programmed death protein ligand 1 inhibitors and molecular targeted therapy can significantly reverse TACE resistance in advanced hepatocellular carcinoma.Compared with TACE alone,the triple therapy reduced the resistance rate from 38.8%to 9.7%and increased the median progression-free survival and median overall survival by 92.3%and 26.8%,respectively.TACE induces tumor antigen release and upregulates programmed death protein ligand 1,activating the effect of immune checkpoint inhibitors while molecular targeted therapy inhibits postembolization vascular regeneration,forming a dynamic synergistic network of embolization-immune activation-vascular inhibition.The maximum tumor diameter,capsule loss,and bilateral distribution were identified as independent predictors.This study provided level I evidence and promoted the transformation of advanced hepatocellular carcinoma treatment from single local intervention to an integrated model of local control-systemic treatment.In the future it will be necessary to analyze the dynamic evolution rules of the tumor microenvironment through crossomics strategies,further explore biomarkers,optimize treatment sequences,and conduct multicenter prospective trials to verify long-term survival benefits and guide the optimization of individualized sequential treatment.展开更多
AIM:To assess early visual outcomes and corneal stability following small incision lenticule extraction(SMILE)in eyes with a pre-planned residual stromal thickness(RST)ranging from 280 to 300μm.METHODS:This retrospec...AIM:To assess early visual outcomes and corneal stability following small incision lenticule extraction(SMILE)in eyes with a pre-planned residual stromal thickness(RST)ranging from 280 to 300μm.METHODS:This retrospective study was designed to evaluate 82 eyes from 82 patients,all of whom had a pre-planned RST of 280 to 300μm and normal corneal topography prior to undergoing SMILE surgery.The mean preoperative spherical equivalent(SE)was-4.82±1.30 D.A standard follow-up protocol was conducted between 1 to 6mo postoperatively.Visual outcomes were recorded using uncorrected visual acuity(UCVA)and subjective refraction.The curvature of the anterior and posterior corneal surfaces,as well as the posterior elevation at the thinnest point(PTE)were derived from the Pentacam system.RESULTS:At the final follow-up,the efficacy index was 1.14±0.15,the safety index was 1.20±0.13.The mean preoperative UDVA was 0.78±0.16 logMAR,which improved significantly to-0.07±0.06 logMAR postoperatively(P<0.001).The preoperative mean SE was-4.82±1.30 D,which decreased to-0.14±0.30 D by the last visit.The curvature of the anterior cornea at the flat meridian(AK1)were 42.62±1.02 D preoperatively,38.56±1.37 D and 38.59±1.39 D at 1 and 6mo after operation,respectively.Corresponding measurements at the steep meridian(AK2)were 43.55±1.14 D preoperatively,39.18±1.46 D and 39.22±1.50 D at 1 and 6mo after operation,respectively.Both AK1 and AK2 remained stable at 1 and 6-mo postoperative intervals(P=0.126 and 0.082,respectively).There were no observed changes in the curvature of the posterior cornea at the flat meridian or at the steep meridian,or the PTE before and after surgery.CONCLUSION:SMILE represents a safe and effective procedure for the correction of myopia and astigmatism in eyes featuring a pre-planned RST ranging from 280 to 300μm accompanied by normal corneal topography,on the premise of strict control of surgical indications.展开更多
Sessile oak(Quercus petraea(Matt.)Liebl.)is widely distributed across most of Europe particularly the hills and lower mountain ranges,so is considered“the oak of the mountains”.This species grows on a wide variety o...Sessile oak(Quercus petraea(Matt.)Liebl.)is widely distributed across most of Europe particularly the hills and lower mountain ranges,so is considered“the oak of the mountains”.This species grows on a wide variety of soils and at altitudes ranging from sea level to 2200 m,especially in Atlantic and sub-Mediterranean climates,and it is sensitive to low winter temperatures,early and late frosts,as well as high summer temperatures.Sessile oak forms both pure and mixed stands especially with broadleaves such as European beech,European hornbeam,small-leaved lime and Acer spp.These form the understorey of sessile oak stands,promoting the natural shedding of lower branches of the oak and protecting the trunk against epicormic branches.Sessile oak is a long-lived,light-demanding and wind-firm species,owing to its taproot and heart-shaped root system.Its timber,one of the most valuable in Europe,is important for fur-niture-making(both solid wood and veneer),construction,barrels,railway sleepers,and is also used as fuelwood.It is one of the few major tree species in Europe that is regener-ated by seed(naturally or artificially)and by stump shoots in high forest,coppice-with-standards and coppice forests.Sessile oak forests are treated in both regular and irregular systems involving silvicultural techniques such as uniform shelterwood,group shelterwood,irregular shelterwood,irregular high forest,coppice-with-standards and simple coppice.Young naturally regenerated stands are managed by weeding,release cutting and cleaning-respacing,keeping the stands quite dense for good natural pruning.Plantations are based on(1)2-4-year old bare-root or container-grown seedlings produced in nurseries using seeds from genetic resources,seed stands and seed orchards.The density of sessile oak plantations(mostly in rows,but also in clusters)is usually between 4000 and 6000 ind.ha^(−1).Sessile oak silviculture of mature stands includes crown thinning,focus-ing on final crop trees(usually a maximum of 100 ind.ha^(−1))and targeting the production of large-diameter and high quality trees at long rotation ages(mostly over 120 years,sometimes 250-300 years).In different parts of Europe,conversion of simple coppices and coppice-with-standards to high forests is continuing.Even though manage-ment of sessile oak forests is very intensive and expensive,requiring active human intervention,the importance of this species in future European forests will increase in the con-text of climate change due to its high resistance to distur-bance,superior drought tolerance and heat stress resistance.展开更多
As the demands for environmental sustainability and the requirements to lower carbon emissions have escalated,New Energy Vehicles(NEVs)have emerged as a compelling substitute for fossil-fuel-run automobiles.Hence,a sm...As the demands for environmental sustainability and the requirements to lower carbon emissions have escalated,New Energy Vehicles(NEVs)have emerged as a compelling substitute for fossil-fuel-run automobiles.Hence,a smart energy management strategy has been developed to enhance the performance of NEVs,maximizing the sustainability of transportation systems and minimizing environmental impacts.The system combines different power reserves,includ-ing a photovoltaic(PV)generator,fuel cell(FC),and battery system,to provide a continuous energy supply,even when the vehicle is running.The Multi-Directional Power Transfer converter for the battery provides the required energy ad-aptation between the input and output.The FC and PV systems are all connected through a direct current/direct current converter to effectively charge the battery whenever excess energy is present.The new energy management technique called Optimized Ant Colony Algorithm is proposed to dynamically allocate power among the different power sources,improving system efficiency.Unlike traditional methods,the suggested approach actively optimizes energy flow accord-ing to actual demand and availability,minimizing energy losses and enhancing sustainability.The MATLAB/Simulink tool was used to simulate the energetic performance of an electric car utilizing the suggested approach.The performance of this multi-source power system is assessed by contrasting the energy the PV and FC generating devices offer,and the energy generation of each recharge system.Additionally,the battery power comparison validates the cost-effectiveness and sustainability of the proposed model in NEVs.Results designate a significant improvement in energy efficiency and overall NEV environmental sustainability within contemporary transportation networks.展开更多
The Tourism Industry plays a critical role in economic growth on the international scene but is equally responsible for contributing to greenhouse gas emissions and energy demand.The research analyzed the global trend...The Tourism Industry plays a critical role in economic growth on the international scene but is equally responsible for contributing to greenhouse gas emissions and energy demand.The research analyzed the global trends of energy consumption(EC)within this industry concerning environmental performance,limits,and prospects of sustained expan-sion.It includes 300 tourism-related businesses across different global economic regions.Key tourism factors include EC,greenhouse gas emissions,renewable energy(RE)use,tourism’s Gross Domestic Product(GDP)contribution,and energy efficiency.Statistical methods such as regression and panel data analysis assess the impact of tourism GDP,carbon emissions and RE.The regression analysis,including linear regression and panel data regression,to assess the influence of factors such as tourism GDP,carbon emissions,RE share,and energy efficiency improvements,providing a data-driven approach to understanding EC in tourism.The findings reveal regional differences,with developed regions consuming more energy per capita,while developing markets show progress in energy-efficient practices.The findings of the linear regression analysis show tourism GDP contribution(β=4,200).The outcomes of the panel data regression analysis show the t-statistic values of carbon emissions(t=5.64).The Difference-in-Differences analysis indicates that tourist GDP is greater in developed regions(β=4,100)compared to developing regions(β=3,500).Carbon emissions(β=4,800)are greater,although RE(β=4,200)and energy efficiency(β=2,500)increase more in developing nations.The research emphasizes expanding use of RE in tourism infrastructure,especially in ecotourism and green hotels.展开更多
Serious fine particulate matter(PM_(2.5))pollution and rapidly increasing of ground-level ozone(O_(3))concentrations are concern issues in China.To achieve the comprehensive control of PM_(2.5)-O_(3) composite air pol...Serious fine particulate matter(PM_(2.5))pollution and rapidly increasing of ground-level ozone(O_(3))concentrations are concern issues in China.To achieve the comprehensive control of PM_(2.5)-O_(3) composite air pollution,exploring the common sources of PM_(2.5) and VOCs is essential.However,previous researches most carried out either PM_(2.5) or VOCs source appointment.In this study,we applied the ensemble source apportionment method to explore the impacts of common sources on PM_(2.5)-VOCs.Subsequently,we obtained the ensemble source impacts on O_(3) combining the extracted VOCs source profile and ozone formation potential.We found that the focus of environmentalmanagement and source control should be varied accordingly for different pollutants.Vehicle emission was the largest contributor(41%)to PM_(2.5)-VOCs,while industrial emission was the main common source(51%)to O_(3).The result showed that the O_(3) production rate is not only related to the VOCs emission,but also to the reactivity of VOCs.In addition,sensitivity tests revealed that temperature was the main factor affecting O_(3) formation.The study provides a framework to explore the common sources impact on PM_(2.5) and VOCs,which is benefit to address both PM_(2.5) and O_(3) mitigations.展开更多
Sequencing of environmental samples has great potential for biodiversity research,but its application is limited by the lack of reliable DNA barcode databases for species identifications.Such a database has been creat...Sequencing of environmental samples has great potential for biodiversity research,but its application is limited by the lack of reliable DNA barcode databases for species identifications.Such a database has been created for epiphytic lichens of Europe,allowing us to compare the results of environmental sequencing with standard taxonomic surveys.The species undetected by taxonomic surveys(what we term the ghost component)amount to about half of the species actually present in hectare plots of Central European forests.Some of these,which currently occur only as diaspores or weakly developed thalli,are likely to be favoured in the course of global change.The ghost component usually represents a larger fraction in managed forests than in old-growth unmanaged forests.The total species composition of different plots is much more similar than suggested by taxonomic surveys alone.On a regional scale,this supports the well-known statement that“everything is everywhere,but,the environment selects”.展开更多
Introduction: Obstructive Sleep Apnea-Hypopnea Syndrome (OSAHS) is a sleep-related breathing disorder characterized by repeated episodes of partial obstruction of the upper airways (hypopnea) and/or intermittent compl...Introduction: Obstructive Sleep Apnea-Hypopnea Syndrome (OSAHS) is a sleep-related breathing disorder characterized by repeated episodes of partial obstruction of the upper airways (hypopnea) and/or intermittent complete obstruction (apnea). Our aim is to study the role of adeno-tonsillectomy in the management of OSAHS in children. Methodology: This was a prospective descriptive study conducted in the ENT-Head and Neck Surgery department of Ignace Deen National Hospital over a six-month period. We included in our study all patients aged 0 to 15 years, presenting with OSAHS of ENT etiology and who had undergone tonsillectomy/adenoidectomy. Results: The frequency of OSAHS was 13%. The mean age of our patients was 5.1 ± 3.8 years. There was a predominance of males (69.6%) with a sex ratio of 2.28. Snoring (98.6%), nasal obstruction (97.1%), and mouth breathing (96.6%) were the main reasons for consultation. Adeno-tonsillectomy (45.4%) was the primary surgical intervention. Almost all children (99.0%) had a simple postoperative course. Conclusion: OSAHS is a condition with a multifactorial etiology. Adeno-tonsillectomy remains the first-line surgical treatment to prevent severe complications and relieve the patient. Multidisciplinary collaboration is essential in the management of OSAHS.展开更多
Craniofacial microsomia(CFM)is a congenital malformation with maxillary and/or mandibular hypoplasia,skin tags,and ear malformations(Luo et al.,2023).Microtia,in its mildest form,can occur alone(Quiat et al.,2023).Wit...Craniofacial microsomia(CFM)is a congenital malformation with maxillary and/or mandibular hypoplasia,skin tags,and ear malformations(Luo et al.,2023).Microtia,in its mildest form,can occur alone(Quiat et al.,2023).With a prevalence of 3.8/100,000(Barisic et al.,2014),CFM is the second most common congenital craniofacial abnormality(Li et al.,2022;Luo et al.,2023).Most cases are sporadic,but familial ones suggest autosomal dominant(AD)or autosomal recessive(AR)(Beleza-Meireles et al.,2014).In 2023,Quiat et al.and Mao et al.successively identified FOXI3 variants in 16 pedigrees and 10 sporadic cases,respectively,accounting for 3.1%of CFM cases(Mao et al.,2023;Quiat et al.,2023).FOX/3 has surpassed SF3B2 as the most frequently identified pathogenic gene for CFM to date(Timberlake et al.,2021;Mao et al.,2023;Quiat et al.,2023).In this study,we performed whole-exome sequencing(WES)on 201 CFM pedigrees and detected FOX/3 variants in 8 AD-inherited pedigrees with 24 patients and 28 unaffected individuals(Fig.1A).展开更多
Hearing loss,which currently affects more than 430 million individuals globally and is projected to exceed 700 million by 2050,predominantly manifests as sensorineural hearing loss(SNHL),for which existing technologie...Hearing loss,which currently affects more than 430 million individuals globally and is projected to exceed 700 million by 2050,predominantly manifests as sensorineural hearing loss(SNHL),for which existing technologies such as hearing aids and cochlear implants fail to restore natural auditory function.Research focusing on protecting inner ear hair cells(HCs)from harmful factors through the regulation of epigenetic modifications has gained significant attention in otology for its role in regulating gene expression without altering the DNA sequence,suggesting potential strategies for preventing and treating SNHL.By synthesizing relevant studies on the inner ear,this review summarizes the emerging roles of histone modifications,DNA methylation,and noncoding RNAs in HC damage,with a focus on their therapeutic potential through epigenetic modulation.Moreover,this review examines the therapeutic potential of epigenetic regulation for the prevention and treatment of SNHL,emphasizing the application of small-molecule epigenetic compounds and their efficacy in modulating gene expression to preserve and restore auditory function.展开更多
AIM:To describe the anatomic characteristics of the lacrimal sac and its adjacent bone structures and to provide surgical recommendations for endoscopic dacryocystorhinostomy(EN-DCR).METHODS:This retrospective compara...AIM:To describe the anatomic characteristics of the lacrimal sac and its adjacent bone structures and to provide surgical recommendations for endoscopic dacryocystorhinostomy(EN-DCR).METHODS:This retrospective comparative study involved 118 sides with complete nasolacrimal duct obstruction and 83 unaffected sides from 126 patients.Computed tomographic-dacryocystography(CT-DCG)scans were performed before lacrimal surgery,and image reconstruction was used to obtain continuous 0.75-mm axial,coronal,and segmental sections for review.The morphology of the lacrimal sac and its relationship with adjacent bony structures were determined for measurement,as well as the obstructed location.RESULTS:The height of the lacrimal sac was 12.99±2.10 mm in this study.The operculum of the middle turbinate(OMT)was located vertically in the lower third of the lacrimal sac.Horizontally,the junction between the maxillary bone and the lacrimal bone(MB-LB)was close to,mostly(60.2%)posterior to,the lacrimal sac.The uncinate process was more frequently attached to the lacrimal bones(75.1%).The obstructions were generally located around the entrance of the nasolacrimal duct(NLD).However,some were placed higher,with 7.63%blocked not lower than the OMT.There was a negative correlation between the diameter of the lacrimal sac and the level of obstruction(r=-0.35,P<0.01).CONCLUSION:In this study,the OMT and MB-LB can be served as the landmarks in EN-DCR.Partial uncinectomy should be performed in most cases.The obstructions were generally located around the entrance of the NLD,but some extreme individual variations strongly implies the importance of CT-DCG scanning before surgery.展开更多
At 20:08,on September 18,2024,an M4.7 earthquake occurred along the Tanlu fault zone in the Feidong County of Hefei,Anhui Province.This earthquake is the largest event in the modern history of Hefei,which caused subst...At 20:08,on September 18,2024,an M4.7 earthquake occurred along the Tanlu fault zone in the Feidong County of Hefei,Anhui Province.This earthquake is the largest event in the modern history of Hefei,which caused substantial social impact.To reveal the seismogenic structure of the M4.7 Feidong earthquake sequence and assess seismic risks,we use data from both the permanent seismic network and a temporary dense nodal array deployed in the epicentral region prior to the mainshock for:(1)accurate location of the earthquake sequence and determination of the focal mechanisms;(2)obtaining the spatiotemporal distribution,b-value,and half-day occurrence frequency of the earthquake sequence.The Sentinel-1 satellite data are used to analyze the coseismic displacement.Additionally,velocity models from regional tomography and local high-resolution 2D active-and passive-source surveys across the Tanlu fault zone in the epicentral area are also used to reveal the detailed geometry of the seismogenic fault.The results indicate:(1)the M4.7 Feidong earthquake sequence is concentrated around 10.5 km in depth along a NW-dipping,subvertical fault which trends NE and is approximately 5 km in length;the focal mechanism solution also reveals that the fault hosting the mainshock is a subvertical strike-slip fault,driven by the regional compressional stress in ENE-WSW;the coseismic horizontal displacement on the surface caused by the M4.7 mainshock has a maximum value close to 1 mm;(2)the regional velocity model shows significant lateral variation in v_(S) in the source region,with the mainshock occurring in the area with higher velocity;high-resolution P-wave velocity structures obtained by full waveform inversion from active sources,and S-wave velocity structures from passive-source ambient noise tomography indicate that the mainshock occurred along the boundary between high-and low-velocity bodies,and the seismogenic fault dips NW;the deep seismic reflection profiling shows that the mainshock occurred within the Jurassic strata;(3)based on these results,we suggest the seismogenic fault for the M4.7 Feidong earthquake is either the Zhuding-Shimenshan fault,one of the major faults in the Tanlu fault zone,or a hidden fault to the east;the intersection of the NE-trending Tanlu fault zone and the WNW-trending Feizhong fault,along with significant velocity variations,likely create local stress concentrations which could have triggered the M4.7 Feidong earthquake sequence;(4)the strong aftershocks following the M4.7 Feidong mainshock did not further extend the fault rupture zone;the active period of the Zhuding-Shimenshan fault was the late Early Pleistocene to Middle Pleistocene,and the imaging results indicate that this fault does not cut through the shallow Feidong depression.In conjunction with the small coseismic rupture area,it is inferred that the probability of surface-rupturing earthquakes in the future is relatively low.展开更多
Quasi-one-dimensional(quasi-1D)van der Waals(vdWs)materials,such as ZrTe_(5),exhibit unique elec-trical properties and quantum phenomena,making them attractive for advanced electronic applications.However,large-scale ...Quasi-one-dimensional(quasi-1D)van der Waals(vdWs)materials,such as ZrTe_(5),exhibit unique elec-trical properties and quantum phenomena,making them attractive for advanced electronic applications.However,large-scale growth of ZrTe_(5) thin films presents challenges.We address this by employing sput-tering,a common semiconductor industry technique.The as-deposited ZrTe_(5) film is amorphous,and post-annealing induces a crystallization process akin to transition-metal dichalcogenides.Our study in-vestigates the electrical and optical properties during this amorphous-to-crystalline transition,reveal-ing insights into the underlying mechanism.This work contributes to the fundamental understanding of quasi-1D materials and introduces a scalable fabrication method for ZrTe_(5) which offers the possibility of fabricating unique future electronic and optical devices.展开更多
Through an understanding of diffusion,precise control of the size distribution of nano-precipitates can be essential to developing superior properties in precipitation-strengthened alloys.Although a significant influe...Through an understanding of diffusion,precise control of the size distribution of nano-precipitates can be essential to developing superior properties in precipitation-strengthened alloys.Although a significant influence of crystallographic orientation on the diffusion process is known to exist in low-symmetry hexagonal close-packed alloys,such anisotropic diffusion is still unidentified in high-symmetry cubic alloys.In this work,we reveal the diffusion-controlled coarsening induced anisotropic growth process of nano-precipitates in an Al-Zn-Mg-Cu alloy.Our experimental and theoretical studies demonstrate that with an increase in the residual stress,the diffusion-controlled coarsening rate is slow along the<112>fiber texture in the alloy matrix with smaller grain sizes.As such,we find that the diffusion activation energy will be increased along the preferred orientation with largest residual stress,which leads to a reduced diffusion-controlled coarsening rate.Specifically,we demonstrate that the increase in the volume fraction of nano-precipitates originates from the rapid grain-boundary controlled coarsening of the grainboundary precipitates.Based on these results,an underlying microstructural design strategy is proposed,involving the crystallographic orientation,the residual stress and the grain boundaries to manipulate the precipitate size distribution in this class of alloys.展开更多
BACKGROUND Patients with cirrhosis with hepatopulmonary syndrome(HPS)have a poorer prognosis.The disease has a subtle onset,symptoms are easily masked,clinical attention is insufficient,and misdiagnosis rates are high...BACKGROUND Patients with cirrhosis with hepatopulmonary syndrome(HPS)have a poorer prognosis.The disease has a subtle onset,symptoms are easily masked,clinical attention is insufficient,and misdiagnosis rates are high.AIM To compare the clinical characteristics of patients with cirrhosis,cirrhosis combined with intrapulmonary vascular dilatation(IPVD),and HPS,and to establish predictive models for IPVD and HPS.METHODS Patients with cirrhosis were prospectively screened at a liver-specialized university teaching hospital.Clinical information and blood samples were collected,and biomarker levels in blood samples were measured.Patients with cirrhosis were divided into three groups:Those with pure cirrhosis,those with combined IPVD,and those with HPS based on contrast-enhanced transthoracic echocardiography results and the pulmonary alveolar-arterial oxygen gradient values.Univariate logistic regression and Least Absolute Shrinkage and Selection Operator(LASSO)regression methods were utilized to identify risk factors for IPVD and HPS,and nomograms were constructed to predict IPVD and HPS.RESULTS A total of 320 patients were analyzed,with 101 diagnosed with IPVD,of whom 54 were diagnosed with HPS.There were statistically significant differences in clinical parameters among these three groups of patients.Among the tested biomarkers,sphingosine 1 phosphate,angiopoietin-2,and platelet-derived growth factor BB were significantly associated with IPVD and HPS in patients with cirrhosis.Following LASSO logistic regression screening,prediction models for IPVD and HPS were established.The area under the receiver operating characteristic curve for IPVD prediction was 0.792(95%confidence interval[CI]:0.737-0.847),and for HPS prediction was 0.891(95%CI:0.848-0.934).CONCLUSION This study systematically compared the clinical characteristics of patients with cirrhosis,IPVD,and HPS,and constructed predictive models for IPVD and HPS based on clinical parameters and laboratory indicators.These models showed good predictive value for IPVD and HPS in patients with cirrhosis.They can assist clinicians in the early prognosis assessment of patients with cirrhosis,ultimately benefiting the patients.展开更多
Objective:Pathologic complete response(pCR)following neoadjuvant therapy(NAT)for gastric cancer(GC)is rare but associated with a favorable prognosis.This study aims to reassess the optimal response population(ORP)foll...Objective:Pathologic complete response(pCR)following neoadjuvant therapy(NAT)for gastric cancer(GC)is rare but associated with a favorable prognosis.This study aims to reassess the optimal response population(ORP)following NAT by evaluating the prognostic outcomes associated with various T and N stages,utilizing multicenter data from China.Methods:Patients who underwent NAT following radical gastrectomy at 10 tertiary hospitals in China between2008 and 2021 were included.The ORP was introduced to explore the disease-free survival(DFS),overall survival(OS),recurrence patterns,and influencing factors following propensity score matching(PSM).Results:A total of 1,076 patients were enrolled in this study(median follow-up period:60 months).We defined ORP as a pCR or tumor infiltration of the mucosal or submucosal layer without lymph node metastasis(pCR or yp T1N0)after NAT.The ORP group comprised 136 patients(12.6%),while the non-ORP group comprised 940patients(87.4%).After applying a 1:4 PSM,we obtained an ORP group of 136 patients and non-ORP group of 544patients.Survival analysis demonstrated that both the 3-year OS(before PSM:89.0%vs.55.0%,P<0.001;after PSM:89.0%vs.55.4%,P<0.001)and DFS(before PSM:85.8%vs.49.7%,P<0.001;after PSM:85.8%vs.50.6%,P<0.001)were significantly superior in the ORP group compared to that in the non-ORP group.Remarkably,adjuvant chemotherapy did not impact the prognosis of patients in the ORP group(3-year OS:89.0%vs.89.7%,P=0.988;3-year DFS:84.9%vs.89.7%,P=0.700).Conclusions:This study reevaluates patients with ORP following NAT,providing a more comprehensive and accurate depiction of the potential beneficiary group and survival outcomes in patients with locally advanced GC.展开更多
This narrative literature review delves into the multifaceted realm of parental involvement in the rehabilitation of children with permanent hearing loss. While existing research has made strides in elucidating parent...This narrative literature review delves into the multifaceted realm of parental involvement in the rehabilitation of children with permanent hearing loss. While existing research has made strides in elucidating parental roles in this context, critical gaps persist, necessitating a comprehensive exploration to inform future endeavors. Our review synthesizes a wide array of studies, identifying these gaps and emphasizing the significance of addressing them. Themes emerging from the literature include the varying degrees of parental engagement, the impact of cultural and socio-economic factors, and the challenges faced by families navigating rehabilitation processes. The synthesis of this literature not only highlights the current state of knowledge but also provides a roadmap for future research efforts. By addressing these gaps, we aim to contribute to a more nuanced understanding of parental involvement in the rehabilitation of children with permanent hearing loss, ultimately fostering improved support systems and holistic care for affected families.展开更多
文摘Introduction: Diabetes remains a real public health problem today, due to its associated morbidity and mortality. It induces numerous metabolic, biochemical, hematological, and immunological changes, responsible for multiple complications. The objective of this study was to characterize clinically and biologically type 2 diabetic patients followed at the National Center for Diabetology and Arterial Hypertension of the Central Hospital of Yaoundé. Method: This prospective, cross-sectional, and analytical study took place from April 5 to July 31, 2023 (4 months) on 100 diabetic patients of both sexes (61 women and 39 men), aged from 31 to 88 years. Body Mass Index, systolic and diastolic blood pressure, and cardiac frequency were measured on each of the patients. Subsequently, blood was collected from the patients for the determination of the complete blood count, HBA1c, lipid profile, serum albumin, TNF-α, and IL-6 levels. The data were analyzed using SPSS 17.0 software. Results: The age average of our population was 56.99 ± 11.51 years, the population was primarily female (61%) and primarily between the ages of 55 and 88. 67% of respondents were married. 59% went to secondary school. 73% of them lived in urban areas. 30% were obese and 40% were overweight, with an average BMI of 28.75 kg/m2. 76% of patients took oral antidiabetic medications. HbA1c level average was 8.65%, with 60% having readings above 6.5%. Low hemoglobin and hypochromia were among the abnormalities of red blood cells observed. Lipid profiles revealed low HDL-cholesterol and high triglycerides and cholesterol. Elevated levels of TNF-α and IL-6 indicated inflammation and cardiovascular risk. Conclusion: These results indicate the necessity of focused diabetic care and management on diabetic patients attending the central hospital of Yaoundé, Cameroon.
文摘Introduction: Foreign bodies (FB) in the lower airways (LAs) constitute a potentially life-threatening emergency requiring immediate management. The objective of our study was to describe the patient pathway and management of foreign bodies in the lower airways. Methodology: This was a descriptive study with retrospective data collection conducted over a 6-year period (January 1, 2014, to December 31, 2019) in the ENT and Head and Neck Surgery Department of Donka National Hospital. Results: We observed a prevalence of 1.79%. The average age was 5.71 years, with a sex ratio of 1.2. However, 82.61% of the cases originated from rural areas. We noted that 78.83% of patients were referred after visiting 1 to 2 healthcare facilities (75.36%). The consultation delay was 3 days. Penetration syndrome was present in 98.56% of cases. The foreign body incidents occurred during play in 54.84% and during meals in 29.09% of cases. Radiographs were performed in 93.9% of cases. Endoscopy was used for both diagnostic and therapeutic purposes in all patients. The foreign bodies were located in the trachea (37.68%), larynx (26.08%), and bronchi (21.73%). Non-organic foreign bodies were predominant (52.17%). Postoperative outcomes were uncomplicated in 95.98% of cases, and the lethality rate was 2.85%. Conclusion: The pathway of patients with foreign bodies in the airways remains unpredictable in our context due to parental hesitations. Early management reduces morbidity and mortality rates.
基金supported by the National Natural Science Foundation of China(No.81700888).
文摘Objective This study aimed to investigate the effect of Astragalus(AST)on osteoporosis(OP)and the downstream mechanisms.Methods Human bone marrow-derived mesenchymal stem cells(hBMSCs)were induced to differentiate into osteogenic cells.After transfection with relevant plasmids,cell proliferation,cell cycle progression,and apoptosis were assessed.Alizarin red staining was used to detect calcium nodules in the cells,alkaline phosphatase(ALP)staining was used to detect ALP activity in the cells,and quantitative reverse transcription-polymerase chain reaction and western blotting were used to determine RUNX2 and Osterix expression levels.An OP rat model was established using ovariectomy and micro-computed tomography scanning.Hematoxylin and eosin staining and Masson’s trichrome staining were used to evaluate the pathological conditions of bone tissues,while immunohistochemistry was conducted to detect RUNX2 in bone tissues.Results AST promoted the osteogenic differentiation of BMSCs,reduced miR-181d-5p expression levels,and increased SOX11 expression levels.Restoring miR-181d-5p expression or reducing SOX11 expression levels reversed the effects of AST on the osteogenic differentiation of hBMSCs.miR-181d-5p was found to target SOX11 in hBMSCs.AST improved OP in rats,and miR-181d-5p overexpression or SOX11 inhibition reversed the therapeutic effects of AST on OP in rats.Conclusion AST promoted the osteogenic differentiation of hBMSCs and alleviated OP by targeting SOX11 via miR-181d-5p.
基金Supported by the National Natural Science Foundation of China,No.82404058Shanghai Municipal Commission of Health and Family Planning,No.2024ZZ2049Beijing Xisike Clinical Oncology Research Foundation,No.Y-HS202401-0011.
文摘In this article we commented on an article published recently by Jiao et al.This retrospective study confirmed that the triple therapy of transarterial chemoembolization(TACE)combined with programmed death protein ligand 1 inhibitors and molecular targeted therapy can significantly reverse TACE resistance in advanced hepatocellular carcinoma.Compared with TACE alone,the triple therapy reduced the resistance rate from 38.8%to 9.7%and increased the median progression-free survival and median overall survival by 92.3%and 26.8%,respectively.TACE induces tumor antigen release and upregulates programmed death protein ligand 1,activating the effect of immune checkpoint inhibitors while molecular targeted therapy inhibits postembolization vascular regeneration,forming a dynamic synergistic network of embolization-immune activation-vascular inhibition.The maximum tumor diameter,capsule loss,and bilateral distribution were identified as independent predictors.This study provided level I evidence and promoted the transformation of advanced hepatocellular carcinoma treatment from single local intervention to an integrated model of local control-systemic treatment.In the future it will be necessary to analyze the dynamic evolution rules of the tumor microenvironment through crossomics strategies,further explore biomarkers,optimize treatment sequences,and conduct multicenter prospective trials to verify long-term survival benefits and guide the optimization of individualized sequential treatment.
文摘AIM:To assess early visual outcomes and corneal stability following small incision lenticule extraction(SMILE)in eyes with a pre-planned residual stromal thickness(RST)ranging from 280 to 300μm.METHODS:This retrospective study was designed to evaluate 82 eyes from 82 patients,all of whom had a pre-planned RST of 280 to 300μm and normal corneal topography prior to undergoing SMILE surgery.The mean preoperative spherical equivalent(SE)was-4.82±1.30 D.A standard follow-up protocol was conducted between 1 to 6mo postoperatively.Visual outcomes were recorded using uncorrected visual acuity(UCVA)and subjective refraction.The curvature of the anterior and posterior corneal surfaces,as well as the posterior elevation at the thinnest point(PTE)were derived from the Pentacam system.RESULTS:At the final follow-up,the efficacy index was 1.14±0.15,the safety index was 1.20±0.13.The mean preoperative UDVA was 0.78±0.16 logMAR,which improved significantly to-0.07±0.06 logMAR postoperatively(P<0.001).The preoperative mean SE was-4.82±1.30 D,which decreased to-0.14±0.30 D by the last visit.The curvature of the anterior cornea at the flat meridian(AK1)were 42.62±1.02 D preoperatively,38.56±1.37 D and 38.59±1.39 D at 1 and 6mo after operation,respectively.Corresponding measurements at the steep meridian(AK2)were 43.55±1.14 D preoperatively,39.18±1.46 D and 39.22±1.50 D at 1 and 6mo after operation,respectively.Both AK1 and AK2 remained stable at 1 and 6-mo postoperative intervals(P=0.126 and 0.082,respectively).There were no observed changes in the curvature of the posterior cornea at the flat meridian or at the steep meridian,or the PTE before and after surgery.CONCLUSION:SMILE represents a safe and effective procedure for the correction of myopia and astigmatism in eyes featuring a pre-planned RST ranging from 280 to 300μm accompanied by normal corneal topography,on the premise of strict control of surgical indications.
文摘Sessile oak(Quercus petraea(Matt.)Liebl.)is widely distributed across most of Europe particularly the hills and lower mountain ranges,so is considered“the oak of the mountains”.This species grows on a wide variety of soils and at altitudes ranging from sea level to 2200 m,especially in Atlantic and sub-Mediterranean climates,and it is sensitive to low winter temperatures,early and late frosts,as well as high summer temperatures.Sessile oak forms both pure and mixed stands especially with broadleaves such as European beech,European hornbeam,small-leaved lime and Acer spp.These form the understorey of sessile oak stands,promoting the natural shedding of lower branches of the oak and protecting the trunk against epicormic branches.Sessile oak is a long-lived,light-demanding and wind-firm species,owing to its taproot and heart-shaped root system.Its timber,one of the most valuable in Europe,is important for fur-niture-making(both solid wood and veneer),construction,barrels,railway sleepers,and is also used as fuelwood.It is one of the few major tree species in Europe that is regener-ated by seed(naturally or artificially)and by stump shoots in high forest,coppice-with-standards and coppice forests.Sessile oak forests are treated in both regular and irregular systems involving silvicultural techniques such as uniform shelterwood,group shelterwood,irregular shelterwood,irregular high forest,coppice-with-standards and simple coppice.Young naturally regenerated stands are managed by weeding,release cutting and cleaning-respacing,keeping the stands quite dense for good natural pruning.Plantations are based on(1)2-4-year old bare-root or container-grown seedlings produced in nurseries using seeds from genetic resources,seed stands and seed orchards.The density of sessile oak plantations(mostly in rows,but also in clusters)is usually between 4000 and 6000 ind.ha^(−1).Sessile oak silviculture of mature stands includes crown thinning,focus-ing on final crop trees(usually a maximum of 100 ind.ha^(−1))and targeting the production of large-diameter and high quality trees at long rotation ages(mostly over 120 years,sometimes 250-300 years).In different parts of Europe,conversion of simple coppices and coppice-with-standards to high forests is continuing.Even though manage-ment of sessile oak forests is very intensive and expensive,requiring active human intervention,the importance of this species in future European forests will increase in the con-text of climate change due to its high resistance to distur-bance,superior drought tolerance and heat stress resistance.
文摘As the demands for environmental sustainability and the requirements to lower carbon emissions have escalated,New Energy Vehicles(NEVs)have emerged as a compelling substitute for fossil-fuel-run automobiles.Hence,a smart energy management strategy has been developed to enhance the performance of NEVs,maximizing the sustainability of transportation systems and minimizing environmental impacts.The system combines different power reserves,includ-ing a photovoltaic(PV)generator,fuel cell(FC),and battery system,to provide a continuous energy supply,even when the vehicle is running.The Multi-Directional Power Transfer converter for the battery provides the required energy ad-aptation between the input and output.The FC and PV systems are all connected through a direct current/direct current converter to effectively charge the battery whenever excess energy is present.The new energy management technique called Optimized Ant Colony Algorithm is proposed to dynamically allocate power among the different power sources,improving system efficiency.Unlike traditional methods,the suggested approach actively optimizes energy flow accord-ing to actual demand and availability,minimizing energy losses and enhancing sustainability.The MATLAB/Simulink tool was used to simulate the energetic performance of an electric car utilizing the suggested approach.The performance of this multi-source power system is assessed by contrasting the energy the PV and FC generating devices offer,and the energy generation of each recharge system.Additionally,the battery power comparison validates the cost-effectiveness and sustainability of the proposed model in NEVs.Results designate a significant improvement in energy efficiency and overall NEV environmental sustainability within contemporary transportation networks.
文摘The Tourism Industry plays a critical role in economic growth on the international scene but is equally responsible for contributing to greenhouse gas emissions and energy demand.The research analyzed the global trends of energy consumption(EC)within this industry concerning environmental performance,limits,and prospects of sustained expan-sion.It includes 300 tourism-related businesses across different global economic regions.Key tourism factors include EC,greenhouse gas emissions,renewable energy(RE)use,tourism’s Gross Domestic Product(GDP)contribution,and energy efficiency.Statistical methods such as regression and panel data analysis assess the impact of tourism GDP,carbon emissions and RE.The regression analysis,including linear regression and panel data regression,to assess the influence of factors such as tourism GDP,carbon emissions,RE share,and energy efficiency improvements,providing a data-driven approach to understanding EC in tourism.The findings reveal regional differences,with developed regions consuming more energy per capita,while developing markets show progress in energy-efficient practices.The findings of the linear regression analysis show tourism GDP contribution(β=4,200).The outcomes of the panel data regression analysis show the t-statistic values of carbon emissions(t=5.64).The Difference-in-Differences analysis indicates that tourist GDP is greater in developed regions(β=4,100)compared to developing regions(β=3,500).Carbon emissions(β=4,800)are greater,although RE(β=4,200)and energy efficiency(β=2,500)increase more in developing nations.The research emphasizes expanding use of RE in tourism infrastructure,especially in ecotourism and green hotels.
基金supported by the National Key Research and Development Program of China(Nos.2023YFC3709500,2023YFC3709502 and 2022YFC3703400)the National Natural Science Foundation of China(No.42077191)+1 种基金the Fundamental Research Funds for the Central Universities(No.63233054)Tianjin Science and Technology Plan Project(No.18PTZWHZ00120).
文摘Serious fine particulate matter(PM_(2.5))pollution and rapidly increasing of ground-level ozone(O_(3))concentrations are concern issues in China.To achieve the comprehensive control of PM_(2.5)-O_(3) composite air pollution,exploring the common sources of PM_(2.5) and VOCs is essential.However,previous researches most carried out either PM_(2.5) or VOCs source appointment.In this study,we applied the ensemble source apportionment method to explore the impacts of common sources on PM_(2.5)-VOCs.Subsequently,we obtained the ensemble source impacts on O_(3) combining the extracted VOCs source profile and ozone formation potential.We found that the focus of environmentalmanagement and source control should be varied accordingly for different pollutants.Vehicle emission was the largest contributor(41%)to PM_(2.5)-VOCs,while industrial emission was the main common source(51%)to O_(3).The result showed that the O_(3) production rate is not only related to the VOCs emission,but also to the reactivity of VOCs.In addition,sensitivity tests revealed that temperature was the main factor affecting O_(3) formation.The study provides a framework to explore the common sources impact on PM_(2.5) and VOCs,which is benefit to address both PM_(2.5) and O_(3) mitigations.
基金supported by the Technology Agency of the Czech Republic(Grant Nos.SS01010270,SS06010420)by a long-term research development grant RVO(Grant No.67985939)。
文摘Sequencing of environmental samples has great potential for biodiversity research,but its application is limited by the lack of reliable DNA barcode databases for species identifications.Such a database has been created for epiphytic lichens of Europe,allowing us to compare the results of environmental sequencing with standard taxonomic surveys.The species undetected by taxonomic surveys(what we term the ghost component)amount to about half of the species actually present in hectare plots of Central European forests.Some of these,which currently occur only as diaspores or weakly developed thalli,are likely to be favoured in the course of global change.The ghost component usually represents a larger fraction in managed forests than in old-growth unmanaged forests.The total species composition of different plots is much more similar than suggested by taxonomic surveys alone.On a regional scale,this supports the well-known statement that“everything is everywhere,but,the environment selects”.
文摘Introduction: Obstructive Sleep Apnea-Hypopnea Syndrome (OSAHS) is a sleep-related breathing disorder characterized by repeated episodes of partial obstruction of the upper airways (hypopnea) and/or intermittent complete obstruction (apnea). Our aim is to study the role of adeno-tonsillectomy in the management of OSAHS in children. Methodology: This was a prospective descriptive study conducted in the ENT-Head and Neck Surgery department of Ignace Deen National Hospital over a six-month period. We included in our study all patients aged 0 to 15 years, presenting with OSAHS of ENT etiology and who had undergone tonsillectomy/adenoidectomy. Results: The frequency of OSAHS was 13%. The mean age of our patients was 5.1 ± 3.8 years. There was a predominance of males (69.6%) with a sex ratio of 2.28. Snoring (98.6%), nasal obstruction (97.1%), and mouth breathing (96.6%) were the main reasons for consultation. Adeno-tonsillectomy (45.4%) was the primary surgical intervention. Almost all children (99.0%) had a simple postoperative course. Conclusion: OSAHS is a condition with a multifactorial etiology. Adeno-tonsillectomy remains the first-line surgical treatment to prevent severe complications and relieve the patient. Multidisciplinary collaboration is essential in the management of OSAHS.
基金support in this study.This work was supported by the National Natural Science Foundation of China(82271889,82172105)the National Key Research and Development Program of China(2021YFC2701000)Shanghai Natural Science Foundation(23ZR1409400,24ZR1409400).
文摘Craniofacial microsomia(CFM)is a congenital malformation with maxillary and/or mandibular hypoplasia,skin tags,and ear malformations(Luo et al.,2023).Microtia,in its mildest form,can occur alone(Quiat et al.,2023).With a prevalence of 3.8/100,000(Barisic et al.,2014),CFM is the second most common congenital craniofacial abnormality(Li et al.,2022;Luo et al.,2023).Most cases are sporadic,but familial ones suggest autosomal dominant(AD)or autosomal recessive(AR)(Beleza-Meireles et al.,2014).In 2023,Quiat et al.and Mao et al.successively identified FOXI3 variants in 16 pedigrees and 10 sporadic cases,respectively,accounting for 3.1%of CFM cases(Mao et al.,2023;Quiat et al.,2023).FOX/3 has surpassed SF3B2 as the most frequently identified pathogenic gene for CFM to date(Timberlake et al.,2021;Mao et al.,2023;Quiat et al.,2023).In this study,we performed whole-exome sequencing(WES)on 201 CFM pedigrees and detected FOX/3 variants in 8 AD-inherited pedigrees with 24 patients and 28 unaffected individuals(Fig.1A).
基金supported by the National Natural Science Foundation of China(Nos.82271158,82301312,82071045,82101219,82071048).
文摘Hearing loss,which currently affects more than 430 million individuals globally and is projected to exceed 700 million by 2050,predominantly manifests as sensorineural hearing loss(SNHL),for which existing technologies such as hearing aids and cochlear implants fail to restore natural auditory function.Research focusing on protecting inner ear hair cells(HCs)from harmful factors through the regulation of epigenetic modifications has gained significant attention in otology for its role in regulating gene expression without altering the DNA sequence,suggesting potential strategies for preventing and treating SNHL.By synthesizing relevant studies on the inner ear,this review summarizes the emerging roles of histone modifications,DNA methylation,and noncoding RNAs in HC damage,with a focus on their therapeutic potential through epigenetic modulation.Moreover,this review examines the therapeutic potential of epigenetic regulation for the prevention and treatment of SNHL,emphasizing the application of small-molecule epigenetic compounds and their efficacy in modulating gene expression to preserve and restore auditory function.
基金Supported by the National Natural Science Foundation of China(No.81700807).
文摘AIM:To describe the anatomic characteristics of the lacrimal sac and its adjacent bone structures and to provide surgical recommendations for endoscopic dacryocystorhinostomy(EN-DCR).METHODS:This retrospective comparative study involved 118 sides with complete nasolacrimal duct obstruction and 83 unaffected sides from 126 patients.Computed tomographic-dacryocystography(CT-DCG)scans were performed before lacrimal surgery,and image reconstruction was used to obtain continuous 0.75-mm axial,coronal,and segmental sections for review.The morphology of the lacrimal sac and its relationship with adjacent bony structures were determined for measurement,as well as the obstructed location.RESULTS:The height of the lacrimal sac was 12.99±2.10 mm in this study.The operculum of the middle turbinate(OMT)was located vertically in the lower third of the lacrimal sac.Horizontally,the junction between the maxillary bone and the lacrimal bone(MB-LB)was close to,mostly(60.2%)posterior to,the lacrimal sac.The uncinate process was more frequently attached to the lacrimal bones(75.1%).The obstructions were generally located around the entrance of the nasolacrimal duct(NLD).However,some were placed higher,with 7.63%blocked not lower than the OMT.There was a negative correlation between the diameter of the lacrimal sac and the level of obstruction(r=-0.35,P<0.01).CONCLUSION:In this study,the OMT and MB-LB can be served as the landmarks in EN-DCR.Partial uncinectomy should be performed in most cases.The obstructions were generally located around the entrance of the NLD,but some extreme individual variations strongly implies the importance of CT-DCG scanning before surgery.
基金supported by the Anhui Province Science and Technology Breakthrough Plan Project(Key Project,No.202423l10050030)the National Natural Science Foundation of China(Fundamental Science Center Category B,No.4248830017)+4 种基金the Joint Funds of National Natural Science Foundation of China(No.U2139204)the National Natural Science Foundation of China Project(No.42104063)the Hefei Government Key Construction Project(No.2024BFFFD02048)the Earthquake Science and Technology Spark Program of the China Earthquake Administration(Nos.XH23020YA,XH24020B)the Anhui Mengcheng National Geophysical Observatory Joint Open Fund(No.MENGO-202307).
文摘At 20:08,on September 18,2024,an M4.7 earthquake occurred along the Tanlu fault zone in the Feidong County of Hefei,Anhui Province.This earthquake is the largest event in the modern history of Hefei,which caused substantial social impact.To reveal the seismogenic structure of the M4.7 Feidong earthquake sequence and assess seismic risks,we use data from both the permanent seismic network and a temporary dense nodal array deployed in the epicentral region prior to the mainshock for:(1)accurate location of the earthquake sequence and determination of the focal mechanisms;(2)obtaining the spatiotemporal distribution,b-value,and half-day occurrence frequency of the earthquake sequence.The Sentinel-1 satellite data are used to analyze the coseismic displacement.Additionally,velocity models from regional tomography and local high-resolution 2D active-and passive-source surveys across the Tanlu fault zone in the epicentral area are also used to reveal the detailed geometry of the seismogenic fault.The results indicate:(1)the M4.7 Feidong earthquake sequence is concentrated around 10.5 km in depth along a NW-dipping,subvertical fault which trends NE and is approximately 5 km in length;the focal mechanism solution also reveals that the fault hosting the mainshock is a subvertical strike-slip fault,driven by the regional compressional stress in ENE-WSW;the coseismic horizontal displacement on the surface caused by the M4.7 mainshock has a maximum value close to 1 mm;(2)the regional velocity model shows significant lateral variation in v_(S) in the source region,with the mainshock occurring in the area with higher velocity;high-resolution P-wave velocity structures obtained by full waveform inversion from active sources,and S-wave velocity structures from passive-source ambient noise tomography indicate that the mainshock occurred along the boundary between high-and low-velocity bodies,and the seismogenic fault dips NW;the deep seismic reflection profiling shows that the mainshock occurred within the Jurassic strata;(3)based on these results,we suggest the seismogenic fault for the M4.7 Feidong earthquake is either the Zhuding-Shimenshan fault,one of the major faults in the Tanlu fault zone,or a hidden fault to the east;the intersection of the NE-trending Tanlu fault zone and the WNW-trending Feizhong fault,along with significant velocity variations,likely create local stress concentrations which could have triggered the M4.7 Feidong earthquake sequence;(4)the strong aftershocks following the M4.7 Feidong mainshock did not further extend the fault rupture zone;the active period of the Zhuding-Shimenshan fault was the late Early Pleistocene to Middle Pleistocene,and the imaging results indicate that this fault does not cut through the shallow Feidong depression.In conjunction with the small coseismic rupture area,it is inferred that the probability of surface-rupturing earthquakes in the future is relatively low.
基金supported by the JSPS KAKENHI(Grant Nos.21H05009,22K20474,and 24K00915)the Murata Science Foundation+1 种基金supported by the Commissioned Research(No.JPJ012368C03701)of the National Institute of Information and Communications Technology(NICT),Japansupport from the Hirose Foundation and Iketani Science and Technology Foundation.
文摘Quasi-one-dimensional(quasi-1D)van der Waals(vdWs)materials,such as ZrTe_(5),exhibit unique elec-trical properties and quantum phenomena,making them attractive for advanced electronic applications.However,large-scale growth of ZrTe_(5) thin films presents challenges.We address this by employing sput-tering,a common semiconductor industry technique.The as-deposited ZrTe_(5) film is amorphous,and post-annealing induces a crystallization process akin to transition-metal dichalcogenides.Our study in-vestigates the electrical and optical properties during this amorphous-to-crystalline transition,reveal-ing insights into the underlying mechanism.This work contributes to the fundamental understanding of quasi-1D materials and introduces a scalable fabrication method for ZrTe_(5) which offers the possibility of fabricating unique future electronic and optical devices.
基金supported by the National Key Research and Development Program of China(No.2017YFF0210002)the National Science and Technology Major Projects of China(No.J2019VII-0015-0155).
文摘Through an understanding of diffusion,precise control of the size distribution of nano-precipitates can be essential to developing superior properties in precipitation-strengthened alloys.Although a significant influence of crystallographic orientation on the diffusion process is known to exist in low-symmetry hexagonal close-packed alloys,such anisotropic diffusion is still unidentified in high-symmetry cubic alloys.In this work,we reveal the diffusion-controlled coarsening induced anisotropic growth process of nano-precipitates in an Al-Zn-Mg-Cu alloy.Our experimental and theoretical studies demonstrate that with an increase in the residual stress,the diffusion-controlled coarsening rate is slow along the<112>fiber texture in the alloy matrix with smaller grain sizes.As such,we find that the diffusion activation energy will be increased along the preferred orientation with largest residual stress,which leads to a reduced diffusion-controlled coarsening rate.Specifically,we demonstrate that the increase in the volume fraction of nano-precipitates originates from the rapid grain-boundary controlled coarsening of the grainboundary precipitates.Based on these results,an underlying microstructural design strategy is proposed,involving the crystallographic orientation,the residual stress and the grain boundaries to manipulate the precipitate size distribution in this class of alloys.
基金Supported by the National Key Research and Development Program of China,No.2022YFC2305002Beijing Natural Science Foundation,No.7232079+1 种基金Middle-aged and Young Talent Incubation Programs(Clinical Research)of Beijing Youan Hospital,No.BJYAYY-YN2022-12,No.BJYAYY-YN2022-13,and No.BJYAYY-YN2022-01the China Postdoctoral Science Foundation,No.2023M732410 and No.2024T170595.
文摘BACKGROUND Patients with cirrhosis with hepatopulmonary syndrome(HPS)have a poorer prognosis.The disease has a subtle onset,symptoms are easily masked,clinical attention is insufficient,and misdiagnosis rates are high.AIM To compare the clinical characteristics of patients with cirrhosis,cirrhosis combined with intrapulmonary vascular dilatation(IPVD),and HPS,and to establish predictive models for IPVD and HPS.METHODS Patients with cirrhosis were prospectively screened at a liver-specialized university teaching hospital.Clinical information and blood samples were collected,and biomarker levels in blood samples were measured.Patients with cirrhosis were divided into three groups:Those with pure cirrhosis,those with combined IPVD,and those with HPS based on contrast-enhanced transthoracic echocardiography results and the pulmonary alveolar-arterial oxygen gradient values.Univariate logistic regression and Least Absolute Shrinkage and Selection Operator(LASSO)regression methods were utilized to identify risk factors for IPVD and HPS,and nomograms were constructed to predict IPVD and HPS.RESULTS A total of 320 patients were analyzed,with 101 diagnosed with IPVD,of whom 54 were diagnosed with HPS.There were statistically significant differences in clinical parameters among these three groups of patients.Among the tested biomarkers,sphingosine 1 phosphate,angiopoietin-2,and platelet-derived growth factor BB were significantly associated with IPVD and HPS in patients with cirrhosis.Following LASSO logistic regression screening,prediction models for IPVD and HPS were established.The area under the receiver operating characteristic curve for IPVD prediction was 0.792(95%confidence interval[CI]:0.737-0.847),and for HPS prediction was 0.891(95%CI:0.848-0.934).CONCLUSION This study systematically compared the clinical characteristics of patients with cirrhosis,IPVD,and HPS,and constructed predictive models for IPVD and HPS based on clinical parameters and laboratory indicators.These models showed good predictive value for IPVD and HPS in patients with cirrhosis.They can assist clinicians in the early prognosis assessment of patients with cirrhosis,ultimately benefiting the patients.
基金supported by the construction funds for“high-level hospitals and clinical specialties”of Fujian Province(No.[2021]76)。
文摘Objective:Pathologic complete response(pCR)following neoadjuvant therapy(NAT)for gastric cancer(GC)is rare but associated with a favorable prognosis.This study aims to reassess the optimal response population(ORP)following NAT by evaluating the prognostic outcomes associated with various T and N stages,utilizing multicenter data from China.Methods:Patients who underwent NAT following radical gastrectomy at 10 tertiary hospitals in China between2008 and 2021 were included.The ORP was introduced to explore the disease-free survival(DFS),overall survival(OS),recurrence patterns,and influencing factors following propensity score matching(PSM).Results:A total of 1,076 patients were enrolled in this study(median follow-up period:60 months).We defined ORP as a pCR or tumor infiltration of the mucosal or submucosal layer without lymph node metastasis(pCR or yp T1N0)after NAT.The ORP group comprised 136 patients(12.6%),while the non-ORP group comprised 940patients(87.4%).After applying a 1:4 PSM,we obtained an ORP group of 136 patients and non-ORP group of 544patients.Survival analysis demonstrated that both the 3-year OS(before PSM:89.0%vs.55.0%,P<0.001;after PSM:89.0%vs.55.4%,P<0.001)and DFS(before PSM:85.8%vs.49.7%,P<0.001;after PSM:85.8%vs.50.6%,P<0.001)were significantly superior in the ORP group compared to that in the non-ORP group.Remarkably,adjuvant chemotherapy did not impact the prognosis of patients in the ORP group(3-year OS:89.0%vs.89.7%,P=0.988;3-year DFS:84.9%vs.89.7%,P=0.700).Conclusions:This study reevaluates patients with ORP following NAT,providing a more comprehensive and accurate depiction of the potential beneficiary group and survival outcomes in patients with locally advanced GC.
文摘This narrative literature review delves into the multifaceted realm of parental involvement in the rehabilitation of children with permanent hearing loss. While existing research has made strides in elucidating parental roles in this context, critical gaps persist, necessitating a comprehensive exploration to inform future endeavors. Our review synthesizes a wide array of studies, identifying these gaps and emphasizing the significance of addressing them. Themes emerging from the literature include the varying degrees of parental engagement, the impact of cultural and socio-economic factors, and the challenges faced by families navigating rehabilitation processes. The synthesis of this literature not only highlights the current state of knowledge but also provides a roadmap for future research efforts. By addressing these gaps, we aim to contribute to a more nuanced understanding of parental involvement in the rehabilitation of children with permanent hearing loss, ultimately fostering improved support systems and holistic care for affected families.
