INTRODUCTIONThe“nonspecific” inflammatory bowel diseases ,ulcerative colitis and Crohn,s represent a group of heterogeneous inflammatory and ulcerative disases of the small and large intestines of unknown etiology ,...INTRODUCTIONThe“nonspecific” inflammatory bowel diseases ,ulcerative colitis and Crohn,s represent a group of heterogeneous inflammatory and ulcerative disases of the small and large intestines of unknown etiology ,associated with many gastrointestinal and systemic complications .Appearing initially as isolated cases in Great Britain and northern Europe during the 19th and early 20th centuries ,they have steadily increased numerically and geographically and today are recognized worldwide.展开更多
It is of interest in an era of increasing biomedical sophisticaton to recall that a relatively short time ago, early in the 20th century, ‘simple' ulcerative colitis was an obscure ‘medical curiosity' emergi...It is of interest in an era of increasing biomedical sophisticaton to recall that a relatively short time ago, early in the 20th century, ‘simple' ulcerative colitis was an obscure ‘medical curiosity' emerging slowly from an unknown past. Crohn's disease was yet unidentified as a separate entity although careful review of the IBD literature documented its early presence, masquerading as ‘intestinal tuberculosis'. Into the 1930s, the etiology and pathogenesis of ulcerative colitis and Crohn's disease were unknown, and investigative hypotheses were scarce. Therapeutic resources were limited and treatment was primitive. At a time of limited biomedical knowledge and minimal clinical awareness, unsubstantiated views prevailed, including ‘vague reactions to foods' (sugar,margarine, corn flakes), deficiency of a ‘protective factor'in pig intestine, and psychiatric disease.展开更多
The objective of this research is to determine the effect earthquakes have on the performance of transportation network systems.To do this,bridge fragility curves,expressed as a function of peak ground acceleration(PG...The objective of this research is to determine the effect earthquakes have on the performance of transportation network systems.To do this,bridge fragility curves,expressed as a function of peak ground acceleration(PGA)and peak ground velocity(PGV),were developed.Network damage was evaluated under the 1994 Northridge earthquake and scenario earthquakes.A probabilistic model was developed to determine the effect of repair of bridge damage on the improvement of the network performance as days passed after the event.As an example,the system performance degradation measured in terms of an index,'Drivers Delay,'is calculated for the Los Angeles area transportation system,and losses due to Drivers Delay with and without retrofit were estimated.展开更多
Natural and human-made disasters such as earthquakes, tsunamis, typhoons, floods, blasts, and impacts have resulted in more than 1.1 million deaths, affected the lives of more than 2 billion people, and caused an esti...Natural and human-made disasters such as earthquakes, tsunamis, typhoons, floods, blasts, and impacts have resulted in more than 1.1 million deaths, affected the lives of more than 2 billion people, and caused an estimated 1.5 trillion USD in damage worldwide between 2003 and 2013. The 2008 Wenchuan earthquake killed 69226 people and left 17923 unaccounted for, it caused a direct loss of 140 billion USD.展开更多
Resilience is the psychological capability to recover from difficulties quickly.Healthcare professionals are especially vulnerable to job-related stress and burnout.Unitary Caring Science is the framework for Watson’...Resilience is the psychological capability to recover from difficulties quickly.Healthcare professionals are especially vulnerable to job-related stress and burnout.Unitary Caring Science is the framework for Watson’s Human Caring Theory,providing a philosophy of practice in healthcare.With the high rates of clinician burnout and psychological issues,it will be significant to unify the human caring theory with research-informed psychological and neuroscience evidence to develop clinicians’resilience-building strategies.The purpose of this article is to introduce a Unitary Caring Science Resilience Model and explain the science behind the core strategies based on Unitary Caring Science philosophy and the psychological and neuroscience research.This model includes six strategies:Embracing loving-kindness for self and others;Nurturing interpersonal and intersubjective connections/relations;Deepening a creative use of self and sense of belonging;Balancing self-learning,self-awareness,and an evolved selfconsciousness;Valuing forgiveness and releasing negativity;Inspiring and maintaining faith-hope.The caring-theory guided resilience-building strategies are proven to alleviate the depletion of clinicians’energy and emotions.Healthcare practices are challenging but rewarding.Clinicians can be emotionally,psychologically,and physically exhausted if they always consider themselves‘giving’and‘doing’institutional tasks without a sense of purpose or fulfillment.The practice can be rewarding if it becomes more aligned with clinicians’value to serve humanity.Through the unitary caring science resilience strategies,clinicians can build resilience as an antidote to clinician burnout and depletion.展开更多
In 2017,Peking Union Medical College(PUMC)celebrated its 100 year anniversary.The anniversary celebration provided an important opportunity to reflect on what PUMC nursing education has accomplished since its inceptio...In 2017,Peking Union Medical College(PUMC)celebrated its 100 year anniversary.The anniversary celebration provided an important opportunity to reflect on what PUMC nursing education has accomplished since its inception in the 1920s.The events also provided an opportunity to consider the future of health and health care,as it may be shaped by nurses in China and around the world.展开更多
Nonlinear delay Caputo fractional differential equations with non-instantaneous impulses are studied and we consider the general case of delay,depending on both the time and the state variable.The case when the lower ...Nonlinear delay Caputo fractional differential equations with non-instantaneous impulses are studied and we consider the general case of delay,depending on both the time and the state variable.The case when the lower limit of the Caputo fractional derivative is fixed at the initial time,and the case when the lower limit of the fractional derivative is changed at the end of each interval of action of the impulse are studied.Practical stability properties,based on the modified Razumikhin method are investigated.Several examples are given in this paper to illustrate the results.展开更多
The present note is basically an announcement of a theoretical and experimental resolution of one of the most basic fundamental problems of physics, namely the very existence and reality of the Aether [1-11]. This is ...The present note is basically an announcement of a theoretical and experimental resolution of one of the most basic fundamental problems of physics, namely the very existence and reality of the Aether [1-11]. This is not only basic philosophy of science or insightful results in theoretical physics and cosmology [1-24] but more than that because it may lead to actually realizing the futuristic dream of free energy [25-28]. Our mathematical and indirect experimental verdict is that the Aether exists and it can be equated to the empty set of pure mathematics [3, 12-16]. More precisely the Aether may be understood for all mathematical and physical purposes as being identical to the empty set [8-14] underlying the Penrose fractal tessellation universe [17] which obeys the A. Connes’ corresponding dimensional function of his noncommutative geometry [18-21].展开更多
Any computer system with known vulnerabilities can be presented using attack graphs. An attacker generally has a mission to reach a goal state that he expects to achieve. Expected Path Length (EPL) [1] in the context ...Any computer system with known vulnerabilities can be presented using attack graphs. An attacker generally has a mission to reach a goal state that he expects to achieve. Expected Path Length (EPL) [1] in the context of an attack graph describes the length or number of steps that the attacker has to take in achieving the goal state. However, EPL varies and it is based on the “state of vulnerabilities” [2] [3] in a given computer system. Any vulnerability throughout its life cycle passes through several stages that we identify as “states of the vulnerability life cycle” [2] [3]. In our previous studies we have developed mathematical models using Markovian theory to estimate the probability of a given vulnerability being in a particular state of its life cycle. There, we have considered a typical model of a computer network system with two computers subject to three vulnerabilities, and developed a method driven by an algorithm to estimate the EPL of this network system as a function of time. This approach is important because it allows us to monitor a computer system during the process of being exploited. Proposed non-homogeneous model in this study estimates the behavior of the EPL as a function of time and therefore act as an index of the risk associated with the network system getting exploited.展开更多
This paper focuses on propagating perturbed two-body motion using orbital elements combined with a novel integration technique.While previous studies show that Modified Chebyshev Picard Iteration(MCPI)is a powerful to...This paper focuses on propagating perturbed two-body motion using orbital elements combined with a novel integration technique.While previous studies show that Modified Chebyshev Picard Iteration(MCPI)is a powerful tool used to propagate position and velocity,the present results show that using orbital elements to propagate the state vector reduces the number of MCPI iterations and nodes required,which is especially useful for reducing the computation time when including computationally-intensive calculations such as Spherical Harmonic gravity,and it also converges for>5.5x as many revolutions using a single segment when compared with cartesian propagation.Results for the Classical Orbital Elements and the Modified Equinoctial Orbital Elements(the latter provides singularity-free solutions)show that state propagation using these variables is inherently well-suited to the propagation method chosen.Additional benefits are achieved using a segmentation scheme,while future expansion to the two-point boundary value problem is expected to increase the domain of convergence compared with the cartesian case.MCPI is an iterative numerical method used to solve linear and nonlinear,ordinary differential equations(ODEs).It is a fusion of orthogonal Chebyshev function approximation with Picard iteration that approximates a long-arc trajectory at every iteration.Previous studies have shown that it outperforms the state of the practice numerical integrators of ODEs in a serial computing environment;since MCPI is inherently massively parallelizable,this capability is expected to increase the computational efficiency of the method presented.展开更多
The limits of medicine have not yet been reached. Numerous human illnesses initially thought to be incurable are reversible under unique and unpredictable individual circumstances.This paper, and the preceding compani...The limits of medicine have not yet been reached. Numerous human illnesses initially thought to be incurable are reversible under unique and unpredictable individual circumstances.This paper, and the preceding companion publication,describes instances of the successful treatment of patients previously labeled as untreatable, including instances of severe ulcerative colitis and Crohn's disease.展开更多
This article explores the boundary layer flow and heat transfer of a viscous nanofluid bounded by a hyperbolically stretching sheet. Effects of Brownian and thermophoretic diffusions on heat transfer and concentration...This article explores the boundary layer flow and heat transfer of a viscous nanofluid bounded by a hyperbolically stretching sheet. Effects of Brownian and thermophoretic diffusions on heat transfer and concentration of nanoparticles are given due attention. The resulting nonlinear problems are computed for analytic and numerical solutions. The effects of Brownian motion and thermophoretic property are found to increase the temperature of the medium and reduce the heat transfer rate. The thermophoretic property thus enriches the concentration while the Brownian motion reduces the concentration of the nanoparticles in the fluid. Opposite effects of these properties are observed on the Sherwood number.展开更多
Building on the various manifestations of the forces latent in the quantum vacuum of spacetime such as Hawking’s radiation and Unruh temperature, we resolve a major paradox connected to an immensely important proposa...Building on the various manifestations of the forces latent in the quantum vacuum of spacetime such as Hawking’s radiation and Unruh temperature, we resolve a major paradox connected to an immensely important proposal by NASA scientists for constructing a practically fuelless spacecraft. In a nutshell, preliminary laboratory work shows that NASA’s electromagnetic drive project is viable and several experiments and measurements show it is real. Yet the proposal violates a fundamental principle of classical mechanics, namely Newton’s third law. The resolution of this paradox is quite straight forward in principle. It is simply the case that although the proposal seems to be based on classical mechanics and classical thinking it is only superficially so. Deep at the roots, the EM drive proposal of NASA is not classical physics but rather based on the vacuum forces of quantum cosmology and the theory of dark energy density of the universe. In fact the proposal is deeply linked to Hawking’s radiation and Unruh temperature, which is explained in some detail in the main body of the present short paper within the frame work of E-infinity Cantorian spacetime theory and D. Gross’ Heterotic superstring theory. In short the quintessence of our explanation is to regard the EM drive as a quasi electromagnetic cavity with an effective event horizon akin to that of a Hawking black hole emitting radiation causing ultimately the needed thrust to push the spacecraft forwards. In addition and by invoking fractal spacetime self similarity we show that a spacecraft will be subject to another cosmic thrust on the large scale of the entire cosmos.展开更多
We demonstrate antimonene as a saturable absorber(SA) to generate an ultrafast mode-locked and Q-switched laser in the 2 μm wavelength region. The two antimonene-based SAs were prepared and inserted separately in a t...We demonstrate antimonene as a saturable absorber(SA) to generate an ultrafast mode-locked and Q-switched laser in the 2 μm wavelength region. The two antimonene-based SAs were prepared and inserted separately in a thulium–holmiumdoped fiber laser to produce the pulsed laser. Antimonene was coated onto a tapered fiber to generate soliton mode-locked pulses and used in thin-film form for the generation of Q-switched pulses. The mode-locking was stable within a pump power of 267 m W–511 m W, and the laser operated at a central wavelength of 1897.4 nm. The mode-locked laser had a pulse width of 1.3 ps and a repetition rate of 12.6 MHz, with a signal-to-noise ratio of 64 d B. Q-switched laser operation was stable at a wavelength of 1890.1 nm within a pump power of 312 m W–381 m W. With the increase in pump power from 312 m W to 381 m W, the repetition rate increased to a maximum of 56.63 k Hz and the pulse width decreased to a minimum value of 2.85 μs. Wide-range tunability of the Q-switched laser was also realized within the wavelength range of1882 nm–1936 nm.展开更多
In 2015,the U.S National Institute of Standards and Technology(NIST)funded the Center of Excellence for Risk-Based Community Resilience Planning(CoE),a fourteen university-based consortium of almost 100 col-laborators...In 2015,the U.S National Institute of Standards and Technology(NIST)funded the Center of Excellence for Risk-Based Community Resilience Planning(CoE),a fourteen university-based consortium of almost 100 col-laborators,including faculty,students,post-doctoral scholars,and NIST researchers.This paper highlights the scientific theory behind the state-of-the-art cloud platform being developed by the CoE-the Interdisciplinary Networked Community Resilience Modeling Environment(IN-CORE).IN-CORE enables communities,consul-tants,and researchers to set up complex interdependent models of an entire community consisting of people,businesses,social institutions,buildings,transportation networks,water networks,and electric power networks and to predict their performance and recovery to hazard scenario events,including uncertainty propagation through the chained models.The modeling environment includes a detailed building inventory,hazard scenario models,building and infrastructure damage(fragility)and recovery functions,social science data-driven house-hold and business models,and computable general equilibrium(CGE)models of local economies.An important aspect of IN-CORE is the characterization of uncertainty and its propagation throughout the chained models of the platform.Three illustrative examples of community testbeds are presented that look at hazard impacts and recovery on population,economics,physical services,and social services.An overview of the IN-CORE technology and scientific implementation is described with a focus on four key community stability areas(CSA)that encompass an array of community resilience metrics(CRM)and support community resilience informed decision-making.Each testbed within IN-CORE has been developed by a team of engineers,social scientists,urban planners,and economists.Community models,begin with a community description,i.e.,people,businesses,buildings,infras-tructure,and progresses to the damage and loss of functions caused by a hazard scenario,i.e.,a flood,tornado,hurricane,or earthquake.This process is accomplished through chaining of modular algorithms,as described.The baseline community characteristics and the hazard-induced damage sets are the initial conditions for the recovery models,which have been the least studied area of community resilience but arguably one of the most important.Communities can then test the effect of mitigation and/or policies and compare the effects of“what if”scenarios on physical,social,and economic metrics with the only requirement being that the change much be able to be numerically modeled in IN-CORE.展开更多
In respond to the legal issue that artificial intelligence(AI)brings,countries all over the world established AI laws research center in succession.AI Laws Research Center of National University of Kaohsiung College o...In respond to the legal issue that artificial intelligence(AI)brings,countries all over the world established AI laws research center in succession.AI Laws Research Center of National University of Kaohsiung College of Law and International AI and Law Research Foundation were established in 2018 and 2019,respectively,and have both played the role in providing research information and assist in solving AI legal issues.展开更多
Background:Polycystic ovary syndrome(PCOS)is an endocrine disorder that occurs in women of child-bearing age.Moreover,PCOS patients have decreased pregnancy rates and clomiphene citrate resistance.The traditional Chin...Background:Polycystic ovary syndrome(PCOS)is an endocrine disorder that occurs in women of child-bearing age.Moreover,PCOS patients have decreased pregnancy rates and clomiphene citrate resistance.The traditional Chinese medicine formula Kun-Tai-1S(KT1S),consisting of the seahorse species hippocampus,has been reported to elicit therapeutic effects in patients with PCOS.However,given the limited resources and global demand for wild hippocampus,whether KT1S with or without hippocampus can elicit similar therapeutic effects has not been confirmed.Methods:KT1S and Kun-Tai-1A(KT1A,KT1S without dry hippocampus)were used to treat a letrozole-induced rat model of PCOS with an established disease.The serum levels of testosterone,luteinizing hormone,anti-Müllerian hormone,and estradiol were determined,the luteinizing hormone/follicle-stimulating hormone ratio was determined,and the ovarian pathology was evaluated.Results:Similar to the therapeutic effects of cyproterone acetate,both the KT1S and KT1A treatments reduced the body weight and ovarian and uterine indices in the rats with PCOS.The serum levels of testosterone,anti-Müllerian hormone,and luteinizing hormone and the luteinizing hormone/follicle-stimulating hormone ratio were significantly lower in the KT1S and KT1A treatment groups compared to the model group(P<0.01 and P<0.05,respectively).Moreover,the histopathological assessment results suggested that both the KT1S and KT1A treatments significantly ameliorated the PCOS pathology in the rats with an established disease,with a reduced number of cystic and atretic follicles and an increased number of corpora lutea being observed in the ovaries.Notably,there was no obvious difference in the disease outcomes between the KT1S and KT1A-treated groups.Network pharmacology analysis revealed that 4’,7-dihydroxyflavanone,sinpemine A,quercetin,8-isopentenyl-kaempferol,and luteolin in KT1A may promote estrogen signaling;furthermore,the nitric oxide regulation pathway is also closely involved.Conclusion:KT1A and KT1S treatments both significantly ameliorated the PCOS-related pathology in rats,suggesting that the hippocampus component is dispensable for KT1S-mediated amelioration.Given the limited resources and global demand for wild hippocampus for use in complementary medicines,our findings may help conserve this species.Together,our results suggest that KT1A is a promising approach for treating PCOS.展开更多
Countries have invested considerable sums of human capital and material resources in the practical application of self-driving cars demonstrating the impressive market opportunity.In light of this trend,Taiwan does no...Countries have invested considerable sums of human capital and material resources in the practical application of self-driving cars demonstrating the impressive market opportunity.In light of this trend,Taiwan does not want to fall behind either.As on-road testing and technological development for self-driving cars continue to develop in different countries,the controversial issues of safety,ethics,liability,and the invasion of privacy continue to emerge.In order to resolve these issues,the government of Taiwan seeks to provide a good environment for AI(artificial intelligence)innovation and applications.This article summarizes and highlights relevant content and key points of Unmanned Vehicles Technology Innovative Experimentation Act,which was legislated in Taiwan in 2018.In addition,it points out the fundamental ethics regulation of AI,which has influenced Taiwan legal policy.展开更多
文摘INTRODUCTIONThe“nonspecific” inflammatory bowel diseases ,ulcerative colitis and Crohn,s represent a group of heterogeneous inflammatory and ulcerative disases of the small and large intestines of unknown etiology ,associated with many gastrointestinal and systemic complications .Appearing initially as isolated cases in Great Britain and northern Europe during the 19th and early 20th centuries ,they have steadily increased numerically and geographically and today are recognized worldwide.
文摘It is of interest in an era of increasing biomedical sophisticaton to recall that a relatively short time ago, early in the 20th century, ‘simple' ulcerative colitis was an obscure ‘medical curiosity' emerging slowly from an unknown past. Crohn's disease was yet unidentified as a separate entity although careful review of the IBD literature documented its early presence, masquerading as ‘intestinal tuberculosis'. Into the 1930s, the etiology and pathogenesis of ulcerative colitis and Crohn's disease were unknown, and investigative hypotheses were scarce. Therapeutic resources were limited and treatment was primitive. At a time of limited biomedical knowledge and minimal clinical awareness, unsubstantiated views prevailed, including ‘vague reactions to foods' (sugar,margarine, corn flakes), deficiency of a ‘protective factor'in pig intestine, and psychiatric disease.
基金The Federal Highway Administration(FHWA)under Contract No.DTFH61-98-C-00094the California Department of Transportation(CALTRANS)
文摘The objective of this research is to determine the effect earthquakes have on the performance of transportation network systems.To do this,bridge fragility curves,expressed as a function of peak ground acceleration(PGA)and peak ground velocity(PGV),were developed.Network damage was evaluated under the 1994 Northridge earthquake and scenario earthquakes.A probabilistic model was developed to determine the effect of repair of bridge damage on the improvement of the network performance as days passed after the event.As an example,the system performance degradation measured in terms of an index,'Drivers Delay,'is calculated for the Los Angeles area transportation system,and losses due to Drivers Delay with and without retrofit were estimated.
文摘Natural and human-made disasters such as earthquakes, tsunamis, typhoons, floods, blasts, and impacts have resulted in more than 1.1 million deaths, affected the lives of more than 2 billion people, and caused an estimated 1.5 trillion USD in damage worldwide between 2003 and 2013. The 2008 Wenchuan earthquake killed 69226 people and left 17923 unaccounted for, it caused a direct loss of 140 billion USD.
文摘Resilience is the psychological capability to recover from difficulties quickly.Healthcare professionals are especially vulnerable to job-related stress and burnout.Unitary Caring Science is the framework for Watson’s Human Caring Theory,providing a philosophy of practice in healthcare.With the high rates of clinician burnout and psychological issues,it will be significant to unify the human caring theory with research-informed psychological and neuroscience evidence to develop clinicians’resilience-building strategies.The purpose of this article is to introduce a Unitary Caring Science Resilience Model and explain the science behind the core strategies based on Unitary Caring Science philosophy and the psychological and neuroscience research.This model includes six strategies:Embracing loving-kindness for self and others;Nurturing interpersonal and intersubjective connections/relations;Deepening a creative use of self and sense of belonging;Balancing self-learning,self-awareness,and an evolved selfconsciousness;Valuing forgiveness and releasing negativity;Inspiring and maintaining faith-hope.The caring-theory guided resilience-building strategies are proven to alleviate the depletion of clinicians’energy and emotions.Healthcare practices are challenging but rewarding.Clinicians can be emotionally,psychologically,and physically exhausted if they always consider themselves‘giving’and‘doing’institutional tasks without a sense of purpose or fulfillment.The practice can be rewarding if it becomes more aligned with clinicians’value to serve humanity.Through the unitary caring science resilience strategies,clinicians can build resilience as an antidote to clinician burnout and depletion.
文摘In 2017,Peking Union Medical College(PUMC)celebrated its 100 year anniversary.The anniversary celebration provided an important opportunity to reflect on what PUMC nursing education has accomplished since its inception in the 1920s.The events also provided an opportunity to consider the future of health and health care,as it may be shaped by nurses in China and around the world.
基金supported by Portuguese funds through the CIDMA-Center for Research and Development in Mathematics and Applicationsthe Portuguese Foundation for Science and Technology(FCT-Fundação para a Ciência e a Tecnologia),within project UIDB/04106/2020Fund Scientific Research MU21FMI007,University of Plovdiv"Paisii Hilendarski".
文摘Nonlinear delay Caputo fractional differential equations with non-instantaneous impulses are studied and we consider the general case of delay,depending on both the time and the state variable.The case when the lower limit of the Caputo fractional derivative is fixed at the initial time,and the case when the lower limit of the fractional derivative is changed at the end of each interval of action of the impulse are studied.Practical stability properties,based on the modified Razumikhin method are investigated.Several examples are given in this paper to illustrate the results.
文摘The present note is basically an announcement of a theoretical and experimental resolution of one of the most basic fundamental problems of physics, namely the very existence and reality of the Aether [1-11]. This is not only basic philosophy of science or insightful results in theoretical physics and cosmology [1-24] but more than that because it may lead to actually realizing the futuristic dream of free energy [25-28]. Our mathematical and indirect experimental verdict is that the Aether exists and it can be equated to the empty set of pure mathematics [3, 12-16]. More precisely the Aether may be understood for all mathematical and physical purposes as being identical to the empty set [8-14] underlying the Penrose fractal tessellation universe [17] which obeys the A. Connes’ corresponding dimensional function of his noncommutative geometry [18-21].
文摘Any computer system with known vulnerabilities can be presented using attack graphs. An attacker generally has a mission to reach a goal state that he expects to achieve. Expected Path Length (EPL) [1] in the context of an attack graph describes the length or number of steps that the attacker has to take in achieving the goal state. However, EPL varies and it is based on the “state of vulnerabilities” [2] [3] in a given computer system. Any vulnerability throughout its life cycle passes through several stages that we identify as “states of the vulnerability life cycle” [2] [3]. In our previous studies we have developed mathematical models using Markovian theory to estimate the probability of a given vulnerability being in a particular state of its life cycle. There, we have considered a typical model of a computer network system with two computers subject to three vulnerabilities, and developed a method driven by an algorithm to estimate the EPL of this network system as a function of time. This approach is important because it allows us to monitor a computer system during the process of being exploited. Proposed non-homogeneous model in this study estimates the behavior of the EPL as a function of time and therefore act as an index of the risk associated with the network system getting exploited.
文摘This paper focuses on propagating perturbed two-body motion using orbital elements combined with a novel integration technique.While previous studies show that Modified Chebyshev Picard Iteration(MCPI)is a powerful tool used to propagate position and velocity,the present results show that using orbital elements to propagate the state vector reduces the number of MCPI iterations and nodes required,which is especially useful for reducing the computation time when including computationally-intensive calculations such as Spherical Harmonic gravity,and it also converges for>5.5x as many revolutions using a single segment when compared with cartesian propagation.Results for the Classical Orbital Elements and the Modified Equinoctial Orbital Elements(the latter provides singularity-free solutions)show that state propagation using these variables is inherently well-suited to the propagation method chosen.Additional benefits are achieved using a segmentation scheme,while future expansion to the two-point boundary value problem is expected to increase the domain of convergence compared with the cartesian case.MCPI is an iterative numerical method used to solve linear and nonlinear,ordinary differential equations(ODEs).It is a fusion of orthogonal Chebyshev function approximation with Picard iteration that approximates a long-arc trajectory at every iteration.Previous studies have shown that it outperforms the state of the practice numerical integrators of ODEs in a serial computing environment;since MCPI is inherently massively parallelizable,this capability is expected to increase the computational efficiency of the method presented.
文摘The limits of medicine have not yet been reached. Numerous human illnesses initially thought to be incurable are reversible under unique and unpredictable individual circumstances.This paper, and the preceding companion publication,describes instances of the successful treatment of patients previously labeled as untreatable, including instances of severe ulcerative colitis and Crohn's disease.
基金supported by the CIIT Research Grant Program(CRGP)of COMSATS Institute of Information Technology,Islamabad,Pakistan(Grant No.1669/CRGP/CIIT/IBD/10/711)
文摘This article explores the boundary layer flow and heat transfer of a viscous nanofluid bounded by a hyperbolically stretching sheet. Effects of Brownian and thermophoretic diffusions on heat transfer and concentration of nanoparticles are given due attention. The resulting nonlinear problems are computed for analytic and numerical solutions. The effects of Brownian motion and thermophoretic property are found to increase the temperature of the medium and reduce the heat transfer rate. The thermophoretic property thus enriches the concentration while the Brownian motion reduces the concentration of the nanoparticles in the fluid. Opposite effects of these properties are observed on the Sherwood number.
文摘Building on the various manifestations of the forces latent in the quantum vacuum of spacetime such as Hawking’s radiation and Unruh temperature, we resolve a major paradox connected to an immensely important proposal by NASA scientists for constructing a practically fuelless spacecraft. In a nutshell, preliminary laboratory work shows that NASA’s electromagnetic drive project is viable and several experiments and measurements show it is real. Yet the proposal violates a fundamental principle of classical mechanics, namely Newton’s third law. The resolution of this paradox is quite straight forward in principle. It is simply the case that although the proposal seems to be based on classical mechanics and classical thinking it is only superficially so. Deep at the roots, the EM drive proposal of NASA is not classical physics but rather based on the vacuum forces of quantum cosmology and the theory of dark energy density of the universe. In fact the proposal is deeply linked to Hawking’s radiation and Unruh temperature, which is explained in some detail in the main body of the present short paper within the frame work of E-infinity Cantorian spacetime theory and D. Gross’ Heterotic superstring theory. In short the quintessence of our explanation is to regard the EM drive as a quasi electromagnetic cavity with an effective event horizon akin to that of a Hawking black hole emitting radiation causing ultimately the needed thrust to push the spacecraft forwards. In addition and by invoking fractal spacetime self similarity we show that a spacecraft will be subject to another cosmic thrust on the large scale of the entire cosmos.
基金support for this work through Grant, HiCoE (PRC-2022)the Universiti Malaya for the funding of this work through Grant Nos. RU005-2021 and MGO23-2022。
文摘We demonstrate antimonene as a saturable absorber(SA) to generate an ultrafast mode-locked and Q-switched laser in the 2 μm wavelength region. The two antimonene-based SAs were prepared and inserted separately in a thulium–holmiumdoped fiber laser to produce the pulsed laser. Antimonene was coated onto a tapered fiber to generate soliton mode-locked pulses and used in thin-film form for the generation of Q-switched pulses. The mode-locking was stable within a pump power of 267 m W–511 m W, and the laser operated at a central wavelength of 1897.4 nm. The mode-locked laser had a pulse width of 1.3 ps and a repetition rate of 12.6 MHz, with a signal-to-noise ratio of 64 d B. Q-switched laser operation was stable at a wavelength of 1890.1 nm within a pump power of 312 m W–381 m W. With the increase in pump power from 312 m W to 381 m W, the repetition rate increased to a maximum of 56.63 k Hz and the pulse width decreased to a minimum value of 2.85 μs. Wide-range tunability of the Q-switched laser was also realized within the wavelength range of1882 nm–1936 nm.
基金The Center for Risk-Based Community Resilience Planning is a NIST-funded Center of Excellencethe Center is funded through a cooperative agreement between the U.S.National Institute of Standards and Tech-nology and Colorado State University(NIST Financial Assistance Award Numbers:70NANB15H044 and 70NANB20H008)。
文摘In 2015,the U.S National Institute of Standards and Technology(NIST)funded the Center of Excellence for Risk-Based Community Resilience Planning(CoE),a fourteen university-based consortium of almost 100 col-laborators,including faculty,students,post-doctoral scholars,and NIST researchers.This paper highlights the scientific theory behind the state-of-the-art cloud platform being developed by the CoE-the Interdisciplinary Networked Community Resilience Modeling Environment(IN-CORE).IN-CORE enables communities,consul-tants,and researchers to set up complex interdependent models of an entire community consisting of people,businesses,social institutions,buildings,transportation networks,water networks,and electric power networks and to predict their performance and recovery to hazard scenario events,including uncertainty propagation through the chained models.The modeling environment includes a detailed building inventory,hazard scenario models,building and infrastructure damage(fragility)and recovery functions,social science data-driven house-hold and business models,and computable general equilibrium(CGE)models of local economies.An important aspect of IN-CORE is the characterization of uncertainty and its propagation throughout the chained models of the platform.Three illustrative examples of community testbeds are presented that look at hazard impacts and recovery on population,economics,physical services,and social services.An overview of the IN-CORE technology and scientific implementation is described with a focus on four key community stability areas(CSA)that encompass an array of community resilience metrics(CRM)and support community resilience informed decision-making.Each testbed within IN-CORE has been developed by a team of engineers,social scientists,urban planners,and economists.Community models,begin with a community description,i.e.,people,businesses,buildings,infras-tructure,and progresses to the damage and loss of functions caused by a hazard scenario,i.e.,a flood,tornado,hurricane,or earthquake.This process is accomplished through chaining of modular algorithms,as described.The baseline community characteristics and the hazard-induced damage sets are the initial conditions for the recovery models,which have been the least studied area of community resilience but arguably one of the most important.Communities can then test the effect of mitigation and/or policies and compare the effects of“what if”scenarios on physical,social,and economic metrics with the only requirement being that the change much be able to be numerically modeled in IN-CORE.
文摘In respond to the legal issue that artificial intelligence(AI)brings,countries all over the world established AI laws research center in succession.AI Laws Research Center of National University of Kaohsiung College of Law and International AI and Law Research Foundation were established in 2018 and 2019,respectively,and have both played the role in providing research information and assist in solving AI legal issues.
文摘Background:Polycystic ovary syndrome(PCOS)is an endocrine disorder that occurs in women of child-bearing age.Moreover,PCOS patients have decreased pregnancy rates and clomiphene citrate resistance.The traditional Chinese medicine formula Kun-Tai-1S(KT1S),consisting of the seahorse species hippocampus,has been reported to elicit therapeutic effects in patients with PCOS.However,given the limited resources and global demand for wild hippocampus,whether KT1S with or without hippocampus can elicit similar therapeutic effects has not been confirmed.Methods:KT1S and Kun-Tai-1A(KT1A,KT1S without dry hippocampus)were used to treat a letrozole-induced rat model of PCOS with an established disease.The serum levels of testosterone,luteinizing hormone,anti-Müllerian hormone,and estradiol were determined,the luteinizing hormone/follicle-stimulating hormone ratio was determined,and the ovarian pathology was evaluated.Results:Similar to the therapeutic effects of cyproterone acetate,both the KT1S and KT1A treatments reduced the body weight and ovarian and uterine indices in the rats with PCOS.The serum levels of testosterone,anti-Müllerian hormone,and luteinizing hormone and the luteinizing hormone/follicle-stimulating hormone ratio were significantly lower in the KT1S and KT1A treatment groups compared to the model group(P<0.01 and P<0.05,respectively).Moreover,the histopathological assessment results suggested that both the KT1S and KT1A treatments significantly ameliorated the PCOS pathology in the rats with an established disease,with a reduced number of cystic and atretic follicles and an increased number of corpora lutea being observed in the ovaries.Notably,there was no obvious difference in the disease outcomes between the KT1S and KT1A-treated groups.Network pharmacology analysis revealed that 4’,7-dihydroxyflavanone,sinpemine A,quercetin,8-isopentenyl-kaempferol,and luteolin in KT1A may promote estrogen signaling;furthermore,the nitric oxide regulation pathway is also closely involved.Conclusion:KT1A and KT1S treatments both significantly ameliorated the PCOS-related pathology in rats,suggesting that the hippocampus component is dispensable for KT1S-mediated amelioration.Given the limited resources and global demand for wild hippocampus for use in complementary medicines,our findings may help conserve this species.Together,our results suggest that KT1A is a promising approach for treating PCOS.
文摘Countries have invested considerable sums of human capital and material resources in the practical application of self-driving cars demonstrating the impressive market opportunity.In light of this trend,Taiwan does not want to fall behind either.As on-road testing and technological development for self-driving cars continue to develop in different countries,the controversial issues of safety,ethics,liability,and the invasion of privacy continue to emerge.In order to resolve these issues,the government of Taiwan seeks to provide a good environment for AI(artificial intelligence)innovation and applications.This article summarizes and highlights relevant content and key points of Unmanned Vehicles Technology Innovative Experimentation Act,which was legislated in Taiwan in 2018.In addition,it points out the fundamental ethics regulation of AI,which has influenced Taiwan legal policy.
