Objective:It was conducted to evaluate the susceptibility to ON(orthorexia nervosa)in the students of the nutrition and dietetics department according to the variables of gender,age and BMI(body massındex).Subjects an...Objective:It was conducted to evaluate the susceptibility to ON(orthorexia nervosa)in the students of the nutrition and dietetics department according to the variables of gender,age and BMI(body massındex).Subjects and Methods:The research covers the students of Marmara University Faculty of Health Sciences,Department of Nutrition and Dietetics in September-October 2017-2018 academic year.The data were collected by survey method.Socio-demographic characteristics and anthropometric measurements of the participants were questioned.EAT-40(Eating Attitude Test),ORTO-15 test and MOCI(Maudsley Obsessive Compulsive Inventory)were used in the study.It was evaluated with SPSS(The Statistical Package for The Social Sciences)21.0 program.Results:205 people participated in the study.EAT-40 scores were found to be≤20 in 94%of the women and 95.2%of the men in the study.The EAT-40 score is≥21 in 6%of women and 4.8%of men in the study(p=0.646>0.05).The ORTO-15 score of 72.3%of women and 71.4%of men is≤40(p=0.934>0.05).EAT-40 average is 10.25±1.10 in underweight.It was found to be 9.21±0.42 in normals and 8.23±0.76 in slightly obese subjects(p=0.758>0.05).ORTO-15 average of those with BMI≤18.49 kg/m2 is 39.59±0.54;Those with 18.50-24.99 kg/m2 were found to be 38.30±0.25 and those with 25.00-29.99 kg/m2 were found to be 39.54±0.75(p=0.098>0.05).As the EAT-40 score increased,the ORTO-15 score decreased.It shows a negative,statistically significant difference between EAT-40 and ORTO-15 scores(p=0.00<0.05).Conclusion:It was concluded that orthorexic tendency is common(72.2%)in nutrition dietetic students,and ON is associated with BMI and EAT-40 scores.In terms of ON,it would be beneficial to conduct comprehensive international studies and determine DSM(Diagnostic and Statistical Manual of Mental Disorders)diagnostic criteria.展开更多
It was aimed to investigate the eating attitudes and its relationships with anxiety and depression at Nutrition and Dietetics students. Students of Nutrition and Dietetics Departments were included in study group (n: ...It was aimed to investigate the eating attitudes and its relationships with anxiety and depression at Nutrition and Dietetics students. Students of Nutrition and Dietetics Departments were included in study group (n: 135) and non-medical students (n: 69) were in control group. Eating attitudes test (EAT-40), Beck Depression Inventory (BDI), and Beck Anxiety Inventory (BAI) were applied to all students and some anthropometric measurements were taken. Body mass index (BMI) and percent of body fat were higher at students in study group than students in control group. There were no significant differences between groups with respect to EAT, BDI and BAI scores. But, BMI and body fat percentage in girls were significantly lower than boys. Both EAT and BDI scores were significantly higher in girls than boys but BAI scores did not differ significantly. It was concluded that students training on Nutrition and Dietetics might have obsessions related to body image. But results of this study revealed that especially young women were more susceptible to eating disorders and depression.展开更多
The education and accreditation system of dietitian-nutritionists has gone through various changes throughout the years.These systems are important to produce competent nutrition professionals.Standardization attempts...The education and accreditation system of dietitian-nutritionists has gone through various changes throughout the years.These systems are important to produce competent nutrition professionals.Standardization attempts have been done internationally by the International Confederation of Dietetic Associations.Many countries have de veloped their own standards to educate and accredit nutrition professionals to ensure the quality of the nutrition and dietetic profession.Through internet and database searching,this paper aims to review and describe the edu cation requirements and accreditation system of nutrition professionals in Indonesia and compare it to other coun tries including the United States,United Kingdom,Australia,Japan,South Korea,Malaysia,Philippines,Thai land,and Singapore.Most countries,including Indonesia,require a minimum of bachelor’s degree to be a nutri tionist and a dietitian,whereas the US requires a minimum of master’s degree.In Indonesia,there is also an addi tional one-year training program after completing the undergraduate study that need to be taken if an individual wants to register as a dietitian or nutritionist,while other countries have included this similar program to their un dergraduate or master course.A certification exam to be a dietitian or nutritionist is required by Indonesia,the US,Japan,South Korea,Philippines,and Thailand,while the remaining others do not.In conclusion,differences in dietetic education and accreditation system were found.Indonesia’s nutrition and dietetic education system al ready meet the International Confederation of Dietetic Associations standard and on par with some countries re viewed here.However,further improvements are still needed.展开更多
Purpose:ATLAS is a cross-sectional study aiming to investigate environmental and genetic determinants of athletic performance in healthy Greek competitive athletes(CA).This article presents the study design,investigat...Purpose:ATLAS is a cross-sectional study aiming to investigate environmental and genetic determinants of athletic performance in healthy Greek competitive athletes(CA).This article presents the study design,investigates the muscle strength performance(MSP)of 289 adult and teenage CA,exercisers,and physically inactive individuals(PI),and proposes predictive models of MSP for adults.Methods:Muscle maximal,speed,and explosive strength(MMS/MSS/MES)at unilateral maximal concentric flexion and extension contraction(FC/EC)were evaluated using Biodex System 3 PRO^(TM)at 60°/s,180°/s,and 300°/s,while additional performance markers were assessed through field ergometric testing.Participants were interviewed about their lifestyle,dietary habits,physical activity,injury,and medical history.Body composition was assessed via bioelectrical impedance.gDNA was extracted from biochemical samples and then genotyped.Statistical analysis was conducted using IBM SPSS Statistics v21.0 and R.Results:Age,fitness,and sex impacted correlations of MSP with body composition and anthropometric measurements(p<0.05).Among CA,females outperformed males in accuracy(p<0.001)while,males outperformed females in anaerobic power,MSP,speed,and endurance(p<0.001).Adult CA outperformed exercisers and PI in MMS,MSS,and MES(p<0.05).Multiple linear regression models,with predictors age,FFM,body extremity,training load explained the majority of variation in MMS(R^(2)_(adj):71.4%–88.9%),MSS(R^(2)_(adj):64.8%–78.4%),and MES(R^(2)_(adj):52.7%–68.4%)at EC,FC,and their mean(p<0.001).Conclusions:Muscle-strengthening strategies should be customized according to individual fitness levels,body composition,and anthropometric measurements.The innovative sex-specific regression models assessing MMS,MSS,and MES at EC and FC provide a framework for personalizing rehabilitation and skill-specific training strategies.展开更多
Chat Generative Pre-trained Transformer(ChatGPT)is a conversational service that uses artificial intelligence and is also known as a chatbot.ChatGPT and similar applications have the potential to be a tool that can be...Chat Generative Pre-trained Transformer(ChatGPT)is a conversational service that uses artificial intelligence and is also known as a chatbot.ChatGPT and similar applications have the potential to be a tool that can be used in the field of psychiatry.Eating disorders affect a large number of individuals worldwide.Tools that encourage and support people with eating disorders to seek mental health services may be critical to helping them get the care they need.However,body image,defined as the totality of a person's thoughts and perceptions about their physical appearance,has been linked to a variety of health problems,particularly among young adults,about eating disorders.There is limited literature on how chatbots respond to or provide information about body image.Preventing eating disorders before they occur is also of great importance.However,young adults who struggle with body image perception may be misled by the information produced by ChatGPT.Studies have yet to clarify whether a chatbot can improve eating disorder-related factors,eating disorder psychopathology,depression,and anxiety or detect eating disorders in advance.This study focuses on the accuracy of ChatGPT in providing information regarding eating disorders and its potential effects on body image perception.展开更多
Metabolic dysfunction-associated steatotic liver disease(MASLD)and inflam-matory bowel disease(IBD)are chronic conditions with complex aetiologies,in which environmental factors and interactions between the gut and li...Metabolic dysfunction-associated steatotic liver disease(MASLD)and inflam-matory bowel disease(IBD)are chronic conditions with complex aetiologies,in which environmental factors and interactions between the gut and liver play a key role.Both conditions are characterised by disturbances in the gut microbiota,which can affect local and systemic inflammatory responses.In particular,inc-reased intestinal permeability promotes the translocation of bacterial components into the portal circulation,contributing to the development of inflammation in the liver.There is growing evidence that modulation of the gut microbiota and imp-roved intestinal barrier function may be of therapeutic importance.The purpose of this review is to discuss the pathogenetic mechanisms that link MASLD and IBD,with a particular emphasis on the influence of the microbiota and environ-mental factors on the development of these diseases.展开更多
BACKGROUND A diagnosis of a chronic disease has been shown to predispose patients to the development of feeding and eating disorders(FEDs).AIM To screen children and adolescents with type 1 diabetes mellitus(T1DM)for ...BACKGROUND A diagnosis of a chronic disease has been shown to predispose patients to the development of feeding and eating disorders(FEDs).AIM To screen children and adolescents with type 1 diabetes mellitus(T1DM)for FEDs and compare them to their counterparts with short stature.METHODS A total of 110 children and adolescents(55 with T1DM and 55 with short stature)were enrolled in the study.The SCOFF questionnaire was used to screen for possible FEDs,while anthropometric and dietary data were also collected.RESULTS Approximately 60%of the children with T1DM screened positive for FEDs compared to 30.9%of the children with short stature.Having a T1DM tripled the chances of screening positive for FEDs and halved the annual growth rate of children with T1DM.No differences were noted in the dietary intake between groups.CONCLUSION The results necessitate the education of pediatric endocrinologists and diabetologists on proper screening and identification of children at risk for developing FEDs.A prompt diagnosis might help children catch up growth and attain their genetically predisposed height.展开更多
In this article,we commented on the work done by Jiang et al,where they syn-thesized a kakkatin derivative,6-(hept-6-yn-1-yloxy)-3-(4-hydroxyphenyl)-7-me-thoxy-4H-chromen-4-one(HK),and investigated its antitumor activ...In this article,we commented on the work done by Jiang et al,where they syn-thesized a kakkatin derivative,6-(hept-6-yn-1-yloxy)-3-(4-hydroxyphenyl)-7-me-thoxy-4H-chromen-4-one(HK),and investigated its antitumor activities and me-chanism in gastric cancer MGC803 and hepatocellular carcinoma(HCC)SMMC-7721 cells.HK was evaluated for its antitumor activity as compared to kakkatin and cisplatin.This article focused on various risk factors of HCC,the mechanism of HCC progression and molecular targets of the kakkatin derivative,and limi-tations of available treatment options.HCC is a predominant form of primary liver cancer characterized by the accumulation of multiple gene modifications,overexpression of protooncogenes,altered immune microenvironment,and infilt-ration by immune cells.Puerariae flos(PF)has been used in traditional medicine in China,Korea,and Japan for lung clearing,spleen awakening,and relieving alcohol hangovers.PF exerts antitumor activity by inhibiting cancer cell prolif-eration,invasion,and migration.PF induces apoptosis in alcoholic HCC via the estrogen-receptor 1-extracellular signal-regulated kinases 1/2 signaling pathway.Kakkatin isolated from PF is known as a hepatoprotective bioflavonoid.The ka-kkatin derivative,HK,exhibited anticancer activity against HCC cell lines by in-hibiting cell proliferation and upregulating nuclear factor kappa B subunit 1 and phosphodiesterase 3B.However,further preclinical and clinical studies are required to establish its therapeutic potential against HCC.展开更多
Background:Weight-related self-stigma(WRSS)is prevalent among individuals with different types of weight status and is associated with a range of negative health outcomes.Social support and coping models explain how i...Background:Weight-related self-stigma(WRSS)is prevalent among individuals with different types of weight status and is associated with a range of negative health outcomes.Social support and coping models explain how individuals may use different coping methods to deal with their mental health needs.Psychological distress(e.g.,depression and stress)could lead to overuse of social media and smartphones.When using social media or smartphones,individuals are likely to be exposed to negative comments regarding weight/shape/size posted on the social media.Consequently,individuals who experience problematic social media use(PSMU)or problematic smartphone use(PSPU)may develop WRSS.Therefore,the present study examined the roles of PSMU and PSPU as mediators in the relationship between psychological distress and WRSS.Methods:Using convenience sampling via an online survey,622 participants with a mean age of 23.70 years(SD=4.33)completed questions assessing sociodemographic variables,psychological distress,PSMU,PSPU,WRSS,and self-reported weight and height.Results:The hierarchical regression models showed that sex(β=0.08,p=0.01),BMI(β=0.39,p<0.001),depression(β=0.21,p=0.001),stress(β=0.18,p=0.01),PSMU(β=0.09,p=0.045),and PSPU(β=0.14,p=0.001)were significant factors for WRSS.Conclusion:The mediation models showed that both PSMU and PSPU were significant mediators in the relationships between depression and stress with WRSS.The present findings provide some evidence for understanding WRSS and has important implications for developing interventions to reduce its negative impact on individuals’health and well-being.展开更多
Background In light of growing concern over eating disorders among young athletes amid cultural and social pressures,this study aimed to assess the prevalence of orthorexia nervosa(ON)risk and evaluate body image perc...Background In light of growing concern over eating disorders among young athletes amid cultural and social pressures,this study aimed to assess the prevalence of orthorexia nervosa(ON)risk and evaluate body image perception and its predictive factors among young football players from Poland and Türkiye.Methods The study involved 171 players aged 15–18 years,recruited from football academies in Poland and Türkiye.The Polish and Turkish versions of the Body-Esteem Scale for Adolescents and Adults(BESAA)were administered to assess body image perception,while the Düsseldorf Orthorexia Scale(DOS)was used to measure ON risk.Anthropometric measurements were taken to calculate Body Mass Index(BMI),which was then referenced to centile charts to determine nutritional status.Results Results indicated that 13%of participants exhibited characteristics of ON,with an additional 26%classified as at elevated risk.Comparative analysis revealed no significant differences in ON prevalence between Polish and Turkish players(p=0.938)and no age-related differences(p=0.694).Among Polish players,a significant positive association emerged between BMI(relative to centile charts)and overall appearance evaluation(BE-Appearance)(p=0.008,partialη^(2)=0.10).This relationship was not observed in Turkish players.Moreover,analysis of ON risk predictors—including age,nationality,nutritional status,and body image—did not identify any single variable as a definitive predictor(all p-values>0.05),with a low predictive capacity(McFadden’s R^(2)=0.03).Conclusion The study revealed a significant risk of ON among young footballers with no clear predictors.展开更多
Intermittent fasting(IF)has emerged as a potential adjunctive strategy in cancer prevention,mitigation,and treatment.This narrative review synthesizes existing literature to explore the relationship between IF and can...Intermittent fasting(IF)has emerged as a potential adjunctive strategy in cancer prevention,mitigation,and treatment.This narrative review synthesizes existing literature to explore the relationship between IF and cancer across 3 dimensions:prevention,mitigation,and treatment.We examine the underlying mechanisms by which IF may reduce cancer risk,including its effects on insulin-like growth factor 1 suppression,autophagy induction,and chronic inflammation reduction.Furthermore,we discuss IF’s potential to enhance the efficacy of conventional cancer therapies by sensitizing cancer cells,promoting apoptosis,and reducing treatmentrelated side effects.While promising,the evidence is still limited,and further research is required to elucidate the long-term impact and optimal implementation of IF in cancer care.This review aims to provide health care professionals and patients with a comprehensive understanding of the potential benefits and risks associated with IF as a complementary approach in the oncology setting.展开更多
Resection of the terminal ileum and ileocecal valve remains the most commonly performed procedure in patients with Crohn's disease.However,despite radical treatment,there is a risk of disease recurrence at the sit...Resection of the terminal ileum and ileocecal valve remains the most commonly performed procedure in patients with Crohn's disease.However,despite radical treatment,there is a risk of disease recurrence at the site of the intestinal ana-stomosis in some cases.Therefore,long-term postoperative management is crucial and requires systematic clinical assessment,endoscopic surveillance,and pharma-cological support when indicated.A key challenge is identifying the risk factors associated with the recurrence of anastomotic failure and defining the principles of follow-up care to prevent secondary intestinal insufficiency.This paper focuses on both surgical and non-surgical factors that may play a role in preventing complications in patients undergoing ileocecal resection,providing a compre-hensive approach to postoperative management.展开更多
The consumption of ultra-processed foods(UPFs)is continuously increasing,and there is growing evidence that these foods contribute to the development and progression of cancer.For oncology patients alone,maintaining n...The consumption of ultra-processed foods(UPFs)is continuously increasing,and there is growing evidence that these foods contribute to the development and progression of cancer.For oncology patients alone,maintaining nutritional status is crucial for tolerating treatments and improving survival.The aim of this paper is to review the role of UPFs in the diet of oncology patients,highlighting their potential health-damaging effects(e.g.,increased inflammation,microbiome disruption,nutrient deficiencies)and potential benefits(e.g.,easy accessibility,high energy content,specially formulated nutritional supplements)particularly in the context of addressing the energy and nutrient needs and nutritional challenges of patients experiencing cancer-related cachexia or anorexia.Using a literature review,we examine how the UPFs can impact oncology patients’health,supporting the quality of life and clinical outcomes of oncology patients.展开更多
Background The decreasing prevalence of physical activity(PA)among urban children in Sub-Saharan Africa is a growing public health concern.More emphasis should focus on examining the influence of parental PA behaviour...Background The decreasing prevalence of physical activity(PA)among urban children in Sub-Saharan Africa is a growing public health concern.More emphasis should focus on examining the influence of parental PA behaviour on the children’s PA patterns.We explored associations of 24hour(h)accelerometer-measured movement behaviours of guardian-child pairs in Nairobi City County,Kenya.Methods This cross-sectional study assessed 80 pairs consisting of children aged 9-14 years and their guardians in one area of low and one area of middle socioeconomic status(SES)(Embakasi Sub-County and Lang’ata Sub-County),in Nairobi City County,Kenya.The study used waist worn Tri-axial Actigraph(GT3X+and ActiSleep+)accelerometers to quantify PA and sedentary time(SED).Association between guardians'and children’s PA was examined using linear regression,adjusting for guardians'educational attainment and household wealth.Results Of the children,42(52.5%)and 76(96.2%)of the guardians were women.Children in low SES areas spent more time(p<0.001)in moderate-to-vigorous physical activity compared to children from middle SES area.The guardians in low SES area were younger and spent more time in light PA(p=0.036)while their counterparts had higher daily SED(p=0.049).Guardian’s SED associated with higher children’s SED(p=0.033)even after adjusting for guardians'educational attainment(p=0.032)and wealth(p=0.05).There was no association between guardians'and children’s MVPA.Conclusion Considered alongside the extant literature,these results suggest that health promotion strategies should aim to reduce parental SED time while also planning to increase children’s PA.展开更多
Background Dysregulation of lipid metabolism and its consequences on growth performance in young ruminants have attracted attention,especially in the context of alternative feeding strategies.This study aims to elucid...Background Dysregulation of lipid metabolism and its consequences on growth performance in young ruminants have attracted attention,especially in the context of alternative feeding strategies.This study aims to elucidate the effects of milk replacer(MR)feeding on growth,lipid metabolism,colonic epithelial gene expression,colonic microbiota composition and systemic metabolism in goat kids compared to breast milk(BM)feeding,addressing a critical knowledge gap in early life nutrition.Methods Ten female goat kids were divided into 2 groups:those fed breast milk(BM group)and those fed a milk replacer(MR group).Over a period of 28 d,body weight was monitored and blood and tissue samples were collected for biochemical,transcriptomic and metabolomic analyses.Profiling of the colonial microbiota was performed using 16S rRNA gene sequencing.Intestinal microbiota transplantation(IMT)experiments in gnotobiotic mice were per-formed to validate causality.Results MR-fed pups exhibited reduced daily body-weight gain due to impaired lipid metabolism as evidenced by lower serum and liver total cholesterol(TC)and non-esterified fatty acid(NEFA)concentrations.Transcriptomic analysis of the colonic epithelium revealed upregulated genes involved in negative regulation of lipid metabolism,concomitant with microbiota shifts characterized by a decrease in Firmicutes and an increase in Actinobacteria.Specifically,genera such as Bifidobacterium and Prevotella were enriched in the MR group,while Clostridium and Fae-calibacterium were depleted.Metabolomics analyses confirmed alterations in bile acid and fatty acid metabolic path-ways.IMT experiments in mice recapitulated the metabolic phenotype observed in MR-fed goats,confirming the role of the microbiota in modulating host lipid metabolism.Conclusions Milk replacer feeding in goat kids disrupts lipid metabolism and gut microbiota dynamics,result-ing in reduced growth rates and metabolic alterations.These findings highlight the importance of early nutritional intervention on metabolic programming and suggest that modulation of the gut microbiota may be a target for improving growth and metabolic health in ruminants.This study contributes to the understanding of nutritional management strategies in livestock and their impact on animal health and productivity.展开更多
Background: Obesity is a chronic complex disease defined by excessive fat deposits that can impair health. Obesity occurs as a result of an imbalance in diet (energy intake) and physical activity (energy expended), mu...Background: Obesity is a chronic complex disease defined by excessive fat deposits that can impair health. Obesity occurs as a result of an imbalance in diet (energy intake) and physical activity (energy expended), multifactorial diseases due to obesogenic environment (availability of convenience food, media influence, etc.), psycho-social factors (social support systems, cultural/environmental influence, etc.) and genetic variants. Other causes are a subgroup of etiological factors (medications, diseases, immobilization, iatrogenic procedures, monogenic disease/genetic syndrome). Obesity is measured clinically by several common tools apart from body mass index (BMI), such as waist circumference (WC), waist-to-hip ratio (WHR), waist-to-height ratio, and neck circumference. WC and WHR are common tools for measuring central obesity while BMI measures generalized obesity. Aims: The goal of this study is to assess the prevalence of obesity amongst health workers of David Umahi Federal University Teaching Hospital, Uburu, Ebonyi state, Southeast Nigeria and to note the prevailing factors. A reliable estimate of the prevalence of obesity among health workers will contribute to the statistics needed to sway policymakers in the country to take urgent and substantial action on the increasing prevalence of obesity, especially in the healthcare industry. Methodology: The study was carried out between May 2024 and June 2024 at the David Umahi Federal University Teaching Hospital situated in Uburu, Ohaozara Local government area of Ebonyi state, Southeast Nigeria. The questionnaire was designed using the Finnish diabetic risk score (FINDRISC). It contained basic comprehending questions on age, gender, exposure to high blood pressure medication, and anthropometric measurement amongst others. Weight was taken with a portable weighing scale and height, with a stadiometer. Both were taken with shoes and headgear removed. The BMI was calculated using the weight (kg) divided by the square of the height (m2). Result: Generally, the prevalence of obesity (>30 kg/m2) in this study was low 17.6% (38), Overweight (BMI 25 - 30), 38.9%, (84) healthy Weight, (BMI 18.5 - 24.9), 43.5% (94). The study revealed that a family history of diabetes was significantly related to higher BMI, with participants more likely to be overweight or obese (p = 0.00030). Similarly, participants with a personal history of diabetes were predominantly in the obese category (p = 0.00038). Waist circumference also showed a strong association with BMI, as larger waist measurements were more common among obese individuals (p = 9.2 × 10−8). In contrast, the analysis found no significant relationships between BMI and age, gender, high blood pressure, or exercise habits. Conclusion: The socio-demographic determinants of obesity in this study were gender, age < 45 years and exposure to exercise. These determinants should form the areas of focus for interventions such as health education and the design of work environments as environments designed to promote physical activities while working will reduce the prevalence of obesity in tertiary institutions.展开更多
BACKGROUND Current guidelines recommend providing malnourished individuals immunonutrition before major gastrointestinal surgery.Nonetheless,the advantages of preoperative immunonutrition remain controversial.AIM To a...BACKGROUND Current guidelines recommend providing malnourished individuals immunonutrition before major gastrointestinal surgery.Nonetheless,the advantages of preoperative immunonutrition remain controversial.AIM To analyses the effects of preoperative immunonutrition and standard oral nutrition supplements on colorectal surgery outcomes.METHODS This study employed a prospective single-center randomized double-blinded comparative approach and was conducted at Hospital Universiti Sains Malaysia between September 2023 and September 2024.In this study,the participants in the experimental group were supplied with a specialized oral supplement enriched with immune-modulating nutrients.Meanwhile,a conventional oral nutrition supplement was provided to the control group.The time to first flatus and the time to first bowel evacuation were the primary outcomes recorded.Incidence of nosocomial infections,surgical site infections,and the total length of hospital stay were considered secondary data.RESULTS This study involved 58 patients who were allocated into two groups.No dropouts were documented.The mean age of the participants was 61.20±12.96,and most were males(63.38%).All participants’baseline and surgical characteristics in both arms were also generally comparable.The participants in this study underwent colorectal surgery,where most had laparoscopic surgery(58%).Based on the results,no significant statistical differences were observed regarding the duration from the first flatus to the first bowel evacuation,the onset of a normal diet,and hospital stay between the experimental and control groups.Both groups also recorded 10(17.24%)infectious complications.CONCLUSION The findings indicated no notable variations in the primary and secondary endpoints despite the theoretical benefits of immune-modulating nutrients.Conclusively,routine preoperative immunonutrition may not provide additional advantages over standard nutrition in this demographic.展开更多
Objective:To evaluate the hepatoprotective effects of the ethanol fraction of Verbascum thapsus L.(EFVT)against CCl4-induced liver injury and elucidate its underlying mechanisms.Methods:The assessment of antioxidant p...Objective:To evaluate the hepatoprotective effects of the ethanol fraction of Verbascum thapsus L.(EFVT)against CCl4-induced liver injury and elucidate its underlying mechanisms.Methods:The assessment of antioxidant properties and cell viability was conducted using the 2,2-diphenyl-1-picrylhydrazyl assay and HepG2 cells,respectively.The in vivo hepatoprotective efficacy of EFVT was evaluated in a rat model of carbon tetrachloride(CCl4)-induced liver injury by determining biochemical parameters,and oxidative stress-and inflammation-related markers.Gas chromatography-mass spectrometry was also employed for the qualitative analysis of its phytochemical composition.Results:GC-MS analysis of EFVT revealed the presence of several bioactive compounds such as 3 methyl mannoside and 9,12-octadecadienoic acid.Oral administration of EFVT significantly mitigated CCl4-induced liver injury,as evidenced by reduced levels of total bilirubin,alkaline phosphatase,alanine aminotransferase,aspartate aminotransferase,and malondialdehyde,boosted activities of catalase and superoxide dismutase,as well as enhanced glutathione levels.Histopathological examinations indicated EFVT restored abnormal liver architecture and reduced inflammation.Additionally,EFVT substantially downregulated the mRNA levels of IL-6,IL-1β,TNF-α,and NF-κB,and upregulated IL-10 expression.Conclusions:These findings underscore the therapeutic potential of EFVT in ameliorating liver damage associated with oxidative stress,providing scientific validation for its traditional utilization in ethnomedicine.展开更多
BACKGROUND Type 2 diabetes(T2D)is a major health concern globally and its prevalence is expected to continue to escalate.Lifestyle intervention is an integral part of T2D management.Meal replacements are often used as...BACKGROUND Type 2 diabetes(T2D)is a major health concern globally and its prevalence is expected to continue to escalate.Lifestyle intervention is an integral part of T2D management.Meal replacements are often used as part of lifestyle intervention programs in T2D and weight management programs.There are various trials being carried out to date;however,a thorough review regarding the usage of meal replacement on its types,dosage and associated outcomes and adverse events is still lacking.AIM To provide a comprehensive overview on existing studies regarding meal replacement usage among patients with T2D,and map out glycemic and weightrelated outcomes along with adverse effects incidences.METHODS This scoping review is conducted based on Arksey and O’Malley’s seminal framework for scoping reviews.A systematic search has been done for studies published between January 2020 and January 2024 across six online databases(Cochrane Library,PubMed,Science Direct,Scopus,Web of Science and Ebscohost Discovery)using specific keywords.Two researchers independently assessed the eligibility of the studies and extracted the data.The selected articles and extracted data were reviewed by all researchers.RESULTS The initial search resulted in an initial count of 53922 articles from which 133 articles were included in this review after eligibility screening.Included studies were categorized based on meal replacement type into low calorie/energy,low glycemic index,protein-rich,low-fat,diabetes-specific formulas,and combined lifestyle intervention programs.Fifty-nine studies reported improvements on hemoglobin A1c,and 70 studies reported positive changes in weight or BMI after the meal replacement intervention.The combination of meal replacements with education,counseling or structured lifestyle interventions has proved to be effective.Only 13 studies reported occurrence of adverse events related to the intervention.Most of the reported incidents were of mild occurrences with constipation being the most reported adverse event.CONCLUSION The results suggest that meal replacements,especially when combined with lifestyle intervention programs and counseling,are an effective and safe strategy in glycemic and weight management among patients with T2D.展开更多
BACKGROUND Picky eating is a commonly observed behavior among children globally,negatively impacting their physical and mental growth.Although common characteristics distinguish peaky eaters,including food selectivity...BACKGROUND Picky eating is a commonly observed behavior among children globally,negatively impacting their physical and mental growth.Although common characteristics distinguish peaky eaters,including food selectivity,food neophobia,and food avoidance,there is no clear definition to assess this behavior.Due to the unavailability of data regarding picky eating,it wasn’t easy to estimate its prevalence.AIM To develop a regional protocol to help healthcare professionals identify and manage mild and moderate picky eating cases.METHODS A virtual roundtable discussion was held in April 2021 to gather the opinions of seven pediatricians and two pediatric dietitians from eight Middle Eastern countries who had great experience in the management of picky eating.The discussion covered different topics,including clearly defining mild and moderate picky eating,identifying the role of diet fortification in these cases,and the possibility of developing a systematic approach to diet fortification.RESULTS The panel identified picky eating as consuming an inadequate amount and variety of foods by rejecting familiar and unfamiliar food.Most of the time,moderate picky eating cases had micronutrient deficiencies with over-or undernutrition;the mild cases only showed inadequate food consumption and/or poor diet quality.Paying attention to the organic red flags like growth faltering and development delay and behavioral red flags,including food fixation and anticipatory gagging,will help healthcare professionals evaluate the picky eaters and the caregivers to care for their children.Although dietary supplementation and commercial food fortification play an important role in picky eating,they were no benefit in the Middle East.CONCLUSION The panel agreed that food fortification through a food-first approach and oral nutritional supplements would be the best for Middle Eastern children.These recommendations would facilitate identifying and managing picky-eating children in the Middle East.展开更多
文摘Objective:It was conducted to evaluate the susceptibility to ON(orthorexia nervosa)in the students of the nutrition and dietetics department according to the variables of gender,age and BMI(body massındex).Subjects and Methods:The research covers the students of Marmara University Faculty of Health Sciences,Department of Nutrition and Dietetics in September-October 2017-2018 academic year.The data were collected by survey method.Socio-demographic characteristics and anthropometric measurements of the participants were questioned.EAT-40(Eating Attitude Test),ORTO-15 test and MOCI(Maudsley Obsessive Compulsive Inventory)were used in the study.It was evaluated with SPSS(The Statistical Package for The Social Sciences)21.0 program.Results:205 people participated in the study.EAT-40 scores were found to be≤20 in 94%of the women and 95.2%of the men in the study.The EAT-40 score is≥21 in 6%of women and 4.8%of men in the study(p=0.646>0.05).The ORTO-15 score of 72.3%of women and 71.4%of men is≤40(p=0.934>0.05).EAT-40 average is 10.25±1.10 in underweight.It was found to be 9.21±0.42 in normals and 8.23±0.76 in slightly obese subjects(p=0.758>0.05).ORTO-15 average of those with BMI≤18.49 kg/m2 is 39.59±0.54;Those with 18.50-24.99 kg/m2 were found to be 38.30±0.25 and those with 25.00-29.99 kg/m2 were found to be 39.54±0.75(p=0.098>0.05).As the EAT-40 score increased,the ORTO-15 score decreased.It shows a negative,statistically significant difference between EAT-40 and ORTO-15 scores(p=0.00<0.05).Conclusion:It was concluded that orthorexic tendency is common(72.2%)in nutrition dietetic students,and ON is associated with BMI and EAT-40 scores.In terms of ON,it would be beneficial to conduct comprehensive international studies and determine DSM(Diagnostic and Statistical Manual of Mental Disorders)diagnostic criteria.
文摘It was aimed to investigate the eating attitudes and its relationships with anxiety and depression at Nutrition and Dietetics students. Students of Nutrition and Dietetics Departments were included in study group (n: 135) and non-medical students (n: 69) were in control group. Eating attitudes test (EAT-40), Beck Depression Inventory (BDI), and Beck Anxiety Inventory (BAI) were applied to all students and some anthropometric measurements were taken. Body mass index (BMI) and percent of body fat were higher at students in study group than students in control group. There were no significant differences between groups with respect to EAT, BDI and BAI scores. But, BMI and body fat percentage in girls were significantly lower than boys. Both EAT and BDI scores were significantly higher in girls than boys but BAI scores did not differ significantly. It was concluded that students training on Nutrition and Dietetics might have obsessions related to body image. But results of this study revealed that especially young women were more susceptible to eating disorders and depression.
基金supported by Faculty of Medicine,Public Health,and Nursing,Universitas Gadjah Mada,Indonesia[grant number 3030/UN1/FKKMK.1.3/PPKE/PT/2024].
文摘The education and accreditation system of dietitian-nutritionists has gone through various changes throughout the years.These systems are important to produce competent nutrition professionals.Standardization attempts have been done internationally by the International Confederation of Dietetic Associations.Many countries have de veloped their own standards to educate and accredit nutrition professionals to ensure the quality of the nutrition and dietetic profession.Through internet and database searching,this paper aims to review and describe the edu cation requirements and accreditation system of nutrition professionals in Indonesia and compare it to other coun tries including the United States,United Kingdom,Australia,Japan,South Korea,Malaysia,Philippines,Thai land,and Singapore.Most countries,including Indonesia,require a minimum of bachelor’s degree to be a nutri tionist and a dietitian,whereas the US requires a minimum of master’s degree.In Indonesia,there is also an addi tional one-year training program after completing the undergraduate study that need to be taken if an individual wants to register as a dietitian or nutritionist,while other countries have included this similar program to their un dergraduate or master course.A certification exam to be a dietitian or nutritionist is required by Indonesia,the US,Japan,South Korea,Philippines,and Thailand,while the remaining others do not.In conclusion,differences in dietetic education and accreditation system were found.Indonesia’s nutrition and dietetic education system al ready meet the International Confederation of Dietetic Associations standard and on par with some countries re viewed here.However,further improvements are still needed.
文摘Purpose:ATLAS is a cross-sectional study aiming to investigate environmental and genetic determinants of athletic performance in healthy Greek competitive athletes(CA).This article presents the study design,investigates the muscle strength performance(MSP)of 289 adult and teenage CA,exercisers,and physically inactive individuals(PI),and proposes predictive models of MSP for adults.Methods:Muscle maximal,speed,and explosive strength(MMS/MSS/MES)at unilateral maximal concentric flexion and extension contraction(FC/EC)were evaluated using Biodex System 3 PRO^(TM)at 60°/s,180°/s,and 300°/s,while additional performance markers were assessed through field ergometric testing.Participants were interviewed about their lifestyle,dietary habits,physical activity,injury,and medical history.Body composition was assessed via bioelectrical impedance.gDNA was extracted from biochemical samples and then genotyped.Statistical analysis was conducted using IBM SPSS Statistics v21.0 and R.Results:Age,fitness,and sex impacted correlations of MSP with body composition and anthropometric measurements(p<0.05).Among CA,females outperformed males in accuracy(p<0.001)while,males outperformed females in anaerobic power,MSP,speed,and endurance(p<0.001).Adult CA outperformed exercisers and PI in MMS,MSS,and MES(p<0.05).Multiple linear regression models,with predictors age,FFM,body extremity,training load explained the majority of variation in MMS(R^(2)_(adj):71.4%–88.9%),MSS(R^(2)_(adj):64.8%–78.4%),and MES(R^(2)_(adj):52.7%–68.4%)at EC,FC,and their mean(p<0.001).Conclusions:Muscle-strengthening strategies should be customized according to individual fitness levels,body composition,and anthropometric measurements.The innovative sex-specific regression models assessing MMS,MSS,and MES at EC and FC provide a framework for personalizing rehabilitation and skill-specific training strategies.
文摘Chat Generative Pre-trained Transformer(ChatGPT)is a conversational service that uses artificial intelligence and is also known as a chatbot.ChatGPT and similar applications have the potential to be a tool that can be used in the field of psychiatry.Eating disorders affect a large number of individuals worldwide.Tools that encourage and support people with eating disorders to seek mental health services may be critical to helping them get the care they need.However,body image,defined as the totality of a person's thoughts and perceptions about their physical appearance,has been linked to a variety of health problems,particularly among young adults,about eating disorders.There is limited literature on how chatbots respond to or provide information about body image.Preventing eating disorders before they occur is also of great importance.However,young adults who struggle with body image perception may be misled by the information produced by ChatGPT.Studies have yet to clarify whether a chatbot can improve eating disorder-related factors,eating disorder psychopathology,depression,and anxiety or detect eating disorders in advance.This study focuses on the accuracy of ChatGPT in providing information regarding eating disorders and its potential effects on body image perception.
文摘Metabolic dysfunction-associated steatotic liver disease(MASLD)and inflam-matory bowel disease(IBD)are chronic conditions with complex aetiologies,in which environmental factors and interactions between the gut and liver play a key role.Both conditions are characterised by disturbances in the gut microbiota,which can affect local and systemic inflammatory responses.In particular,inc-reased intestinal permeability promotes the translocation of bacterial components into the portal circulation,contributing to the development of inflammation in the liver.There is growing evidence that modulation of the gut microbiota and imp-roved intestinal barrier function may be of therapeutic importance.The purpose of this review is to discuss the pathogenetic mechanisms that link MASLD and IBD,with a particular emphasis on the influence of the microbiota and environ-mental factors on the development of these diseases.
文摘BACKGROUND A diagnosis of a chronic disease has been shown to predispose patients to the development of feeding and eating disorders(FEDs).AIM To screen children and adolescents with type 1 diabetes mellitus(T1DM)for FEDs and compare them to their counterparts with short stature.METHODS A total of 110 children and adolescents(55 with T1DM and 55 with short stature)were enrolled in the study.The SCOFF questionnaire was used to screen for possible FEDs,while anthropometric and dietary data were also collected.RESULTS Approximately 60%of the children with T1DM screened positive for FEDs compared to 30.9%of the children with short stature.Having a T1DM tripled the chances of screening positive for FEDs and halved the annual growth rate of children with T1DM.No differences were noted in the dietary intake between groups.CONCLUSION The results necessitate the education of pediatric endocrinologists and diabetologists on proper screening and identification of children at risk for developing FEDs.A prompt diagnosis might help children catch up growth and attain their genetically predisposed height.
基金Supported by the Indian Council of Scientific and Industrial Research,No.MLP0204(CSIR-IHBT no.5712).
文摘In this article,we commented on the work done by Jiang et al,where they syn-thesized a kakkatin derivative,6-(hept-6-yn-1-yloxy)-3-(4-hydroxyphenyl)-7-me-thoxy-4H-chromen-4-one(HK),and investigated its antitumor activities and me-chanism in gastric cancer MGC803 and hepatocellular carcinoma(HCC)SMMC-7721 cells.HK was evaluated for its antitumor activity as compared to kakkatin and cisplatin.This article focused on various risk factors of HCC,the mechanism of HCC progression and molecular targets of the kakkatin derivative,and limi-tations of available treatment options.HCC is a predominant form of primary liver cancer characterized by the accumulation of multiple gene modifications,overexpression of protooncogenes,altered immune microenvironment,and infilt-ration by immune cells.Puerariae flos(PF)has been used in traditional medicine in China,Korea,and Japan for lung clearing,spleen awakening,and relieving alcohol hangovers.PF exerts antitumor activity by inhibiting cancer cell prolif-eration,invasion,and migration.PF induces apoptosis in alcoholic HCC via the estrogen-receptor 1-extracellular signal-regulated kinases 1/2 signaling pathway.Kakkatin isolated from PF is known as a hepatoprotective bioflavonoid.The ka-kkatin derivative,HK,exhibited anticancer activity against HCC cell lines by in-hibiting cell proliferation and upregulating nuclear factor kappa B subunit 1 and phosphodiesterase 3B.However,further preclinical and clinical studies are required to establish its therapeutic potential against HCC.
基金supported in part by(received funding from)the Ministry of Science and Technology,Taiwan(MOST 110-2410-H-006-115,MOST 111-2410-H-006-100)the National Science and Technology Council,Taiwan(NSTC 112-2410-H-006-089-SS2)+1 种基金the Higher Education Sprout Project,the Ministry of Education at the Headquarters of University Advancement at the National Cheng Kung University(NCKU)the 2021 Southeast and South Asia and Taiwan Universities Joint Research Scheme(NCKU 31).
文摘Background:Weight-related self-stigma(WRSS)is prevalent among individuals with different types of weight status and is associated with a range of negative health outcomes.Social support and coping models explain how individuals may use different coping methods to deal with their mental health needs.Psychological distress(e.g.,depression and stress)could lead to overuse of social media and smartphones.When using social media or smartphones,individuals are likely to be exposed to negative comments regarding weight/shape/size posted on the social media.Consequently,individuals who experience problematic social media use(PSMU)or problematic smartphone use(PSPU)may develop WRSS.Therefore,the present study examined the roles of PSMU and PSPU as mediators in the relationship between psychological distress and WRSS.Methods:Using convenience sampling via an online survey,622 participants with a mean age of 23.70 years(SD=4.33)completed questions assessing sociodemographic variables,psychological distress,PSMU,PSPU,WRSS,and self-reported weight and height.Results:The hierarchical regression models showed that sex(β=0.08,p=0.01),BMI(β=0.39,p<0.001),depression(β=0.21,p=0.001),stress(β=0.18,p=0.01),PSMU(β=0.09,p=0.045),and PSPU(β=0.14,p=0.001)were significant factors for WRSS.Conclusion:The mediation models showed that both PSMU and PSPU were significant mediators in the relationships between depression and stress with WRSS.The present findings provide some evidence for understanding WRSS and has important implications for developing interventions to reduce its negative impact on individuals’health and well-being.
文摘Background In light of growing concern over eating disorders among young athletes amid cultural and social pressures,this study aimed to assess the prevalence of orthorexia nervosa(ON)risk and evaluate body image perception and its predictive factors among young football players from Poland and Türkiye.Methods The study involved 171 players aged 15–18 years,recruited from football academies in Poland and Türkiye.The Polish and Turkish versions of the Body-Esteem Scale for Adolescents and Adults(BESAA)were administered to assess body image perception,while the Düsseldorf Orthorexia Scale(DOS)was used to measure ON risk.Anthropometric measurements were taken to calculate Body Mass Index(BMI),which was then referenced to centile charts to determine nutritional status.Results Results indicated that 13%of participants exhibited characteristics of ON,with an additional 26%classified as at elevated risk.Comparative analysis revealed no significant differences in ON prevalence between Polish and Turkish players(p=0.938)and no age-related differences(p=0.694).Among Polish players,a significant positive association emerged between BMI(relative to centile charts)and overall appearance evaluation(BE-Appearance)(p=0.008,partialη^(2)=0.10).This relationship was not observed in Turkish players.Moreover,analysis of ON risk predictors—including age,nationality,nutritional status,and body image—did not identify any single variable as a definitive predictor(all p-values>0.05),with a low predictive capacity(McFadden’s R^(2)=0.03).Conclusion The study revealed a significant risk of ON among young footballers with no clear predictors.
文摘Intermittent fasting(IF)has emerged as a potential adjunctive strategy in cancer prevention,mitigation,and treatment.This narrative review synthesizes existing literature to explore the relationship between IF and cancer across 3 dimensions:prevention,mitigation,and treatment.We examine the underlying mechanisms by which IF may reduce cancer risk,including its effects on insulin-like growth factor 1 suppression,autophagy induction,and chronic inflammation reduction.Furthermore,we discuss IF’s potential to enhance the efficacy of conventional cancer therapies by sensitizing cancer cells,promoting apoptosis,and reducing treatmentrelated side effects.While promising,the evidence is still limited,and further research is required to elucidate the long-term impact and optimal implementation of IF in cancer care.This review aims to provide health care professionals and patients with a comprehensive understanding of the potential benefits and risks associated with IF as a complementary approach in the oncology setting.
文摘Resection of the terminal ileum and ileocecal valve remains the most commonly performed procedure in patients with Crohn's disease.However,despite radical treatment,there is a risk of disease recurrence at the site of the intestinal ana-stomosis in some cases.Therefore,long-term postoperative management is crucial and requires systematic clinical assessment,endoscopic surveillance,and pharma-cological support when indicated.A key challenge is identifying the risk factors associated with the recurrence of anastomotic failure and defining the principles of follow-up care to prevent secondary intestinal insufficiency.This paper focuses on both surgical and non-surgical factors that may play a role in preventing complications in patients undergoing ileocecal resection,providing a compre-hensive approach to postoperative management.
文摘The consumption of ultra-processed foods(UPFs)is continuously increasing,and there is growing evidence that these foods contribute to the development and progression of cancer.For oncology patients alone,maintaining nutritional status is crucial for tolerating treatments and improving survival.The aim of this paper is to review the role of UPFs in the diet of oncology patients,highlighting their potential health-damaging effects(e.g.,increased inflammation,microbiome disruption,nutrient deficiencies)and potential benefits(e.g.,easy accessibility,high energy content,specially formulated nutritional supplements)particularly in the context of addressing the energy and nutrient needs and nutritional challenges of patients experiencing cancer-related cachexia or anorexia.Using a literature review,we examine how the UPFs can impact oncology patients’health,supporting the quality of life and clinical outcomes of oncology patients.
基金funded by the Finnish Ministry of Foreign Affairs through the Higher Education Institutions Institutional Cooperation Instrument,grant no.HEL7M0453-82(https://www.oph.fi/en/programmes/hei-ici-programme).
文摘Background The decreasing prevalence of physical activity(PA)among urban children in Sub-Saharan Africa is a growing public health concern.More emphasis should focus on examining the influence of parental PA behaviour on the children’s PA patterns.We explored associations of 24hour(h)accelerometer-measured movement behaviours of guardian-child pairs in Nairobi City County,Kenya.Methods This cross-sectional study assessed 80 pairs consisting of children aged 9-14 years and their guardians in one area of low and one area of middle socioeconomic status(SES)(Embakasi Sub-County and Lang’ata Sub-County),in Nairobi City County,Kenya.The study used waist worn Tri-axial Actigraph(GT3X+and ActiSleep+)accelerometers to quantify PA and sedentary time(SED).Association between guardians'and children’s PA was examined using linear regression,adjusting for guardians'educational attainment and household wealth.Results Of the children,42(52.5%)and 76(96.2%)of the guardians were women.Children in low SES areas spent more time(p<0.001)in moderate-to-vigorous physical activity compared to children from middle SES area.The guardians in low SES area were younger and spent more time in light PA(p=0.036)while their counterparts had higher daily SED(p=0.049).Guardian’s SED associated with higher children’s SED(p=0.033)even after adjusting for guardians'educational attainment(p=0.032)and wealth(p=0.05).There was no association between guardians'and children’s MVPA.Conclusion Considered alongside the extant literature,these results suggest that health promotion strategies should aim to reduce parental SED time while also planning to increase children’s PA.
基金financially supported by National Natural Science Foundation of China (32160801)China Agriculture Research System (CARS-39-12)+1 种基金Young Talent Fund of Association for Science and Technology in Shaanxi, China (2023-6-2-1)“Double-chain” project on livestock breeding (2022GDTSLD-46)
文摘Background Dysregulation of lipid metabolism and its consequences on growth performance in young ruminants have attracted attention,especially in the context of alternative feeding strategies.This study aims to elucidate the effects of milk replacer(MR)feeding on growth,lipid metabolism,colonic epithelial gene expression,colonic microbiota composition and systemic metabolism in goat kids compared to breast milk(BM)feeding,addressing a critical knowledge gap in early life nutrition.Methods Ten female goat kids were divided into 2 groups:those fed breast milk(BM group)and those fed a milk replacer(MR group).Over a period of 28 d,body weight was monitored and blood and tissue samples were collected for biochemical,transcriptomic and metabolomic analyses.Profiling of the colonial microbiota was performed using 16S rRNA gene sequencing.Intestinal microbiota transplantation(IMT)experiments in gnotobiotic mice were per-formed to validate causality.Results MR-fed pups exhibited reduced daily body-weight gain due to impaired lipid metabolism as evidenced by lower serum and liver total cholesterol(TC)and non-esterified fatty acid(NEFA)concentrations.Transcriptomic analysis of the colonic epithelium revealed upregulated genes involved in negative regulation of lipid metabolism,concomitant with microbiota shifts characterized by a decrease in Firmicutes and an increase in Actinobacteria.Specifically,genera such as Bifidobacterium and Prevotella were enriched in the MR group,while Clostridium and Fae-calibacterium were depleted.Metabolomics analyses confirmed alterations in bile acid and fatty acid metabolic path-ways.IMT experiments in mice recapitulated the metabolic phenotype observed in MR-fed goats,confirming the role of the microbiota in modulating host lipid metabolism.Conclusions Milk replacer feeding in goat kids disrupts lipid metabolism and gut microbiota dynamics,result-ing in reduced growth rates and metabolic alterations.These findings highlight the importance of early nutritional intervention on metabolic programming and suggest that modulation of the gut microbiota may be a target for improving growth and metabolic health in ruminants.This study contributes to the understanding of nutritional management strategies in livestock and their impact on animal health and productivity.
文摘Background: Obesity is a chronic complex disease defined by excessive fat deposits that can impair health. Obesity occurs as a result of an imbalance in diet (energy intake) and physical activity (energy expended), multifactorial diseases due to obesogenic environment (availability of convenience food, media influence, etc.), psycho-social factors (social support systems, cultural/environmental influence, etc.) and genetic variants. Other causes are a subgroup of etiological factors (medications, diseases, immobilization, iatrogenic procedures, monogenic disease/genetic syndrome). Obesity is measured clinically by several common tools apart from body mass index (BMI), such as waist circumference (WC), waist-to-hip ratio (WHR), waist-to-height ratio, and neck circumference. WC and WHR are common tools for measuring central obesity while BMI measures generalized obesity. Aims: The goal of this study is to assess the prevalence of obesity amongst health workers of David Umahi Federal University Teaching Hospital, Uburu, Ebonyi state, Southeast Nigeria and to note the prevailing factors. A reliable estimate of the prevalence of obesity among health workers will contribute to the statistics needed to sway policymakers in the country to take urgent and substantial action on the increasing prevalence of obesity, especially in the healthcare industry. Methodology: The study was carried out between May 2024 and June 2024 at the David Umahi Federal University Teaching Hospital situated in Uburu, Ohaozara Local government area of Ebonyi state, Southeast Nigeria. The questionnaire was designed using the Finnish diabetic risk score (FINDRISC). It contained basic comprehending questions on age, gender, exposure to high blood pressure medication, and anthropometric measurement amongst others. Weight was taken with a portable weighing scale and height, with a stadiometer. Both were taken with shoes and headgear removed. The BMI was calculated using the weight (kg) divided by the square of the height (m2). Result: Generally, the prevalence of obesity (>30 kg/m2) in this study was low 17.6% (38), Overweight (BMI 25 - 30), 38.9%, (84) healthy Weight, (BMI 18.5 - 24.9), 43.5% (94). The study revealed that a family history of diabetes was significantly related to higher BMI, with participants more likely to be overweight or obese (p = 0.00030). Similarly, participants with a personal history of diabetes were predominantly in the obese category (p = 0.00038). Waist circumference also showed a strong association with BMI, as larger waist measurements were more common among obese individuals (p = 9.2 × 10−8). In contrast, the analysis found no significant relationships between BMI and age, gender, high blood pressure, or exercise habits. Conclusion: The socio-demographic determinants of obesity in this study were gender, age < 45 years and exposure to exercise. These determinants should form the areas of focus for interventions such as health education and the design of work environments as environments designed to promote physical activities while working will reduce the prevalence of obesity in tertiary institutions.
基金Supported by Universiti Sains Malaysia,Short-Term Grant,No.R501-LR-RND002-0000000342-0000.
文摘BACKGROUND Current guidelines recommend providing malnourished individuals immunonutrition before major gastrointestinal surgery.Nonetheless,the advantages of preoperative immunonutrition remain controversial.AIM To analyses the effects of preoperative immunonutrition and standard oral nutrition supplements on colorectal surgery outcomes.METHODS This study employed a prospective single-center randomized double-blinded comparative approach and was conducted at Hospital Universiti Sains Malaysia between September 2023 and September 2024.In this study,the participants in the experimental group were supplied with a specialized oral supplement enriched with immune-modulating nutrients.Meanwhile,a conventional oral nutrition supplement was provided to the control group.The time to first flatus and the time to first bowel evacuation were the primary outcomes recorded.Incidence of nosocomial infections,surgical site infections,and the total length of hospital stay were considered secondary data.RESULTS This study involved 58 patients who were allocated into two groups.No dropouts were documented.The mean age of the participants was 61.20±12.96,and most were males(63.38%).All participants’baseline and surgical characteristics in both arms were also generally comparable.The participants in this study underwent colorectal surgery,where most had laparoscopic surgery(58%).Based on the results,no significant statistical differences were observed regarding the duration from the first flatus to the first bowel evacuation,the onset of a normal diet,and hospital stay between the experimental and control groups.Both groups also recorded 10(17.24%)infectious complications.CONCLUSION The findings indicated no notable variations in the primary and secondary endpoints despite the theoretical benefits of immune-modulating nutrients.Conclusively,routine preoperative immunonutrition may not provide additional advantages over standard nutrition in this demographic.
文摘Objective:To evaluate the hepatoprotective effects of the ethanol fraction of Verbascum thapsus L.(EFVT)against CCl4-induced liver injury and elucidate its underlying mechanisms.Methods:The assessment of antioxidant properties and cell viability was conducted using the 2,2-diphenyl-1-picrylhydrazyl assay and HepG2 cells,respectively.The in vivo hepatoprotective efficacy of EFVT was evaluated in a rat model of carbon tetrachloride(CCl4)-induced liver injury by determining biochemical parameters,and oxidative stress-and inflammation-related markers.Gas chromatography-mass spectrometry was also employed for the qualitative analysis of its phytochemical composition.Results:GC-MS analysis of EFVT revealed the presence of several bioactive compounds such as 3 methyl mannoside and 9,12-octadecadienoic acid.Oral administration of EFVT significantly mitigated CCl4-induced liver injury,as evidenced by reduced levels of total bilirubin,alkaline phosphatase,alanine aminotransferase,aspartate aminotransferase,and malondialdehyde,boosted activities of catalase and superoxide dismutase,as well as enhanced glutathione levels.Histopathological examinations indicated EFVT restored abnormal liver architecture and reduced inflammation.Additionally,EFVT substantially downregulated the mRNA levels of IL-6,IL-1β,TNF-α,and NF-κB,and upregulated IL-10 expression.Conclusions:These findings underscore the therapeutic potential of EFVT in ameliorating liver damage associated with oxidative stress,providing scientific validation for its traditional utilization in ethnomedicine.
文摘BACKGROUND Type 2 diabetes(T2D)is a major health concern globally and its prevalence is expected to continue to escalate.Lifestyle intervention is an integral part of T2D management.Meal replacements are often used as part of lifestyle intervention programs in T2D and weight management programs.There are various trials being carried out to date;however,a thorough review regarding the usage of meal replacement on its types,dosage and associated outcomes and adverse events is still lacking.AIM To provide a comprehensive overview on existing studies regarding meal replacement usage among patients with T2D,and map out glycemic and weightrelated outcomes along with adverse effects incidences.METHODS This scoping review is conducted based on Arksey and O’Malley’s seminal framework for scoping reviews.A systematic search has been done for studies published between January 2020 and January 2024 across six online databases(Cochrane Library,PubMed,Science Direct,Scopus,Web of Science and Ebscohost Discovery)using specific keywords.Two researchers independently assessed the eligibility of the studies and extracted the data.The selected articles and extracted data were reviewed by all researchers.RESULTS The initial search resulted in an initial count of 53922 articles from which 133 articles were included in this review after eligibility screening.Included studies were categorized based on meal replacement type into low calorie/energy,low glycemic index,protein-rich,low-fat,diabetes-specific formulas,and combined lifestyle intervention programs.Fifty-nine studies reported improvements on hemoglobin A1c,and 70 studies reported positive changes in weight or BMI after the meal replacement intervention.The combination of meal replacements with education,counseling or structured lifestyle interventions has proved to be effective.Only 13 studies reported occurrence of adverse events related to the intervention.Most of the reported incidents were of mild occurrences with constipation being the most reported adverse event.CONCLUSION The results suggest that meal replacements,especially when combined with lifestyle intervention programs and counseling,are an effective and safe strategy in glycemic and weight management among patients with T2D.
文摘BACKGROUND Picky eating is a commonly observed behavior among children globally,negatively impacting their physical and mental growth.Although common characteristics distinguish peaky eaters,including food selectivity,food neophobia,and food avoidance,there is no clear definition to assess this behavior.Due to the unavailability of data regarding picky eating,it wasn’t easy to estimate its prevalence.AIM To develop a regional protocol to help healthcare professionals identify and manage mild and moderate picky eating cases.METHODS A virtual roundtable discussion was held in April 2021 to gather the opinions of seven pediatricians and two pediatric dietitians from eight Middle Eastern countries who had great experience in the management of picky eating.The discussion covered different topics,including clearly defining mild and moderate picky eating,identifying the role of diet fortification in these cases,and the possibility of developing a systematic approach to diet fortification.RESULTS The panel identified picky eating as consuming an inadequate amount and variety of foods by rejecting familiar and unfamiliar food.Most of the time,moderate picky eating cases had micronutrient deficiencies with over-or undernutrition;the mild cases only showed inadequate food consumption and/or poor diet quality.Paying attention to the organic red flags like growth faltering and development delay and behavioral red flags,including food fixation and anticipatory gagging,will help healthcare professionals evaluate the picky eaters and the caregivers to care for their children.Although dietary supplementation and commercial food fortification play an important role in picky eating,they were no benefit in the Middle East.CONCLUSION The panel agreed that food fortification through a food-first approach and oral nutritional supplements would be the best for Middle Eastern children.These recommendations would facilitate identifying and managing picky-eating children in the Middle East.
