In this paper,by proposing a novel and low-cost Ag salt paste,a robustly and large-area(35×35 mm^(2))bare Cu to Cu bonding was realized under a low sintering pressure of 0.8 MPa and a low sintering temperature of...In this paper,by proposing a novel and low-cost Ag salt paste,a robustly and large-area(35×35 mm^(2))bare Cu to Cu bonding was realized under a low sintering pressure of 0.8 MPa and a low sintering temperature of 300℃ in air atmospheric conditions.The relationship between the bonding strength and microstructure changes of sintered Ag under various bonding conditions was investigated in detail.The large-area bonded plate exhibits low porosity about 10%and low percentage of voids,which result in ultra-high bonding strength over 58 MPa.More importantly,the introduction of reducing agent formic acid(CH_(2)O_(2))and the low porosity successfully improve the anti-oxidation of novel Ag salt paste during sintering process,result in pure Cu-Ag-Cu bonding.The cross-section of the Ag joints was obtained to explain the bonding pattern,in which Cu was oxidized only at the edge of the sintering interface,and no Cu oxide generated in middle bonding section.The development of novel Ag salt paste successfully addresses the energy-intensive process and low bonding strength faced by large-scale sintering,which greatly promotes the high-temperature applications of power device.展开更多
A sodium-cooled fast reactor (SFR) is being developed at the Korea Atomic Energy Research Institute (KAERI). As in-core structural material for a SFR, advanced radiation resistant ODS steel (ARROS) has been developed....A sodium-cooled fast reactor (SFR) is being developed at the Korea Atomic Energy Research Institute (KAERI). As in-core structural material for a SFR, advanced radiation resistant ODS steel (ARROS) has been developed. This paper summarizes the current status of ARROS development regarding an ODS steel composition, fabrication technology of ODS steel structural components and key joining technologies of ODS steel structural components.展开更多
Embryonic stem(ES) cells are isolated from theinner cell mass of a blastocyst, and are used for the generation of gene-modified animals. In mice, the transplantation of gene-modified ES cells into recipient blastocyst...Embryonic stem(ES) cells are isolated from theinner cell mass of a blastocyst, and are used for the generation of gene-modified animals. In mice, the transplantation of gene-modified ES cells into recipient blastocysts leads to the creation of gene-targeted mice such as knock-in and knock-out mice; these gene-targeted mice contribute greatly to scientific development. Although the rat is considered a useful laboratory animal alongside the mouse, fewer genemodified rats have been produced due to the lack of robust establishment methods for rat ES cells. A new method for establishing rat ES cells using signaling inhibitors was reported in 2008. By considering the characteristics of rat ES cells, recent research has made progress in improving conditions for the stable culture of rat ES cells in order to generate gene-modified rats efficiently. In this review, we summarize several advanced methods to maintain rat ES cells and generate gene-targeted rats.展开更多
Korea imports about 97% of its energy resources as its available energy resources are extremely limited. Thus, the role of nuclear power in electricity generation is expected to become more important in future years. ...Korea imports about 97% of its energy resources as its available energy resources are extremely limited. Thus, the role of nuclear power in electricity generation is expected to become more important in future years. A fast reactor system is one of the most promising options for electricity generation with an efficient utilization of uranium resources and a reduction of radioactive wastes. Based on the experiences gained during the development of the conceptual designs for KALIMER （Korea advanced liquid metal reactor）, the KAERI （Korea Atomic Energy Research Institute） is currently developing advanced SFR （sodium cooled fast reactor） design concepts that can better meet the Gen IV （Generation IV） technology goals. The long-term advanced SFR development plan will be carried out toward the construction of an advanced SFR demonstration plant by 2028. Advanced concept design studies and the development of the advanced SFR technologies necessary for its commercialization and basic key technologies carried out by KAERI are included in this paper.展开更多
SINOPEC has successfully developed a series of hydrogenation technologies aimed at gasoline quality upgrading including pre-hydrotreating of FCC feed and post-hydrotreating of FCC naphtha that are playing a pivotal ro...SINOPEC has successfully developed a series of hydrogenation technologies aimed at gasoline quality upgrading including pre-hydrotreating of FCC feed and post-hydrotreating of FCC naphtha that are playing a pivotal role for gasoline quality upgrading.It is necessary in the next phase of technical development to carry out an in-depth study on the reaction mechanism,high-activity catalysts,process technology and engineering techniques to further raise the technical level,reduce investment and production cost in a bid to provide technical support for low-cost upgrading of gasoline quality.展开更多
Background:Impaired reproductive performance is the largest contributing factor for the removal of boars from commercial systems.Intrauterine growth restricted piglets represent 25%of the total number of piglets born ...Background:Impaired reproductive performance is the largest contributing factor for the removal of boars from commercial systems.Intrauterine growth restricted piglets represent 25%of the total number of piglets born and have impaired reproductive performance.This study aimed to improve the understanding of temporal changes in testicular gene expression during testes development in fetuses of different size.The lightest and closest to mean litter weight(CTMLW)male Large White×Landrace littermates were collected at gestational days(GD)45,60 and 90(n=5-6 litters/GD).Results:Testes weight and testes weight as a percentage of fetal weight were not associated with fetal size at GD60 or 90.Fetal plasma testosterone was not associated with fetal size at GD90.There was no association between fetal size and seminiferous tubule area and number,number of germ or Sertoli cells per tubule.The lightest fetuses tended to have wider seminiferous tubules compared to the CTMLW fetuses at GD90(P=0.077).The testicular expression of KI67(P≤0.01)and BAX:BCL2 ratio(P=0.058)mRNAs decreased as gestation progressed.Greater SPP1 mRNA expression was observed at GD60 when compared with GD45 and 90(P≤0.05).Lower expression of DMRT1 and SPP1(P<0.01)mRNAs was observed in testes associated with the lightest fetuses compared to the CTMLW fetuses at GD90.Conclusions:These findings provide novel insights into the expression profiles of genes associated with testicular development and function.Further,these data suggest that programming of reproductive potential in IUGR boars occurs late in gestation,providing a platform for further mechanistic investigation.展开更多
Shuttlecock used for badminton is light in mass so that its flight locus is strongly influenced by air. The highest launching velocity of the shuttlecock by professional badminton players exceeds speeds of over 83.3 m...Shuttlecock used for badminton is light in mass so that its flight locus is strongly influenced by air. The highest launching velocity of the shuttlecock by professional badminton players exceeds speeds of over 83.3 m/s （300 km/hr）. In this study, a new badminton server machine was developed. The badminton machine can launch the shuttlecocks at wide range of speeds up to 52.8 m/s （190 km/hr） and with many shot types such as smash, clear and so on, which are easily achieved. The finite element models of a shuttlecock with feathers and the badminton machine were made, and the launching simulations of the shuttlecock were tried. The roller with a large diameter attained a higher speed of the shuttlecock than the small rollers for all kinds of launching conditions. The taper angles of the roller edge and the insert height of the shuttlecock relative to the roller surface were optimized for attaining the maximum shuttle speed by the response surface approach. After the optimization, the performance of the badminton machine had been improved about 7% as the shuttle speeds increase and the stress causing the shuttle deterioration decreased.展开更多
China has rich deep shale gas resources,which will be an important source for an increase in China’s natural gas production in a certain period in the future.Realizing its large-scale efficient development is of stra...China has rich deep shale gas resources,which will be an important source for an increase in China’s natural gas production in a certain period in the future.Realizing its large-scale efficient development is of strategic importance in ensuring national energy security.This article analyses and summarizes the opportunities and challenges in China’s scale economy development of shale gas.Opportunities:China’s natural gas market has immense potential,and the prospects for shale gas development are broad;the national and local governments value and support the exploration and development of shale gas;there is a rich resource base that allows for rapid production increase and stable output of deep shale gas;technological advancements will accelerate the pace of scale economy development of deep gas resources.展开更多
As a typical tight sandstone gasfield with strong heterogeneity,the Sulige Gas Field in the Ordos Basin faces major challenges in its development because the reservoirs in the gasfield are small in effective sand scal...As a typical tight sandstone gasfield with strong heterogeneity,the Sulige Gas Field in the Ordos Basin faces major challenges in its development because the reservoirs in the gasfield are small in effective sand scale,rapid in lithologic change,strong in plane heterogeneity,and poor in connectivity.How to scientifically deploy development wells to improve the recovery is the most important issue for the successful development of this kind of gasfields.Therefore,a well inference analysis was conducted tofigure out the impact of well pattern density on the recovery based on the research of many years in gasfield development methods and the summary of practical effect.In this paper,we put forward for thefirst time the concept of inter-well interference probability,and present the relationship between the probability of inter-well interference and well pattern density of the Sulige Gas Field.Then we established a mathematical model for the optimization of development well pattern by combiningfine sand anatomy,reservoir engineering,numerical simulation and economic evaluation,and obtained a quantitative relationship between recovery and well pattern density.Furthermore,on the basis of comprehensive analysis,a reasonable development well pattern was designed for the Sulige Gas Field:this well pattern is parallelogram in shape,with a density of 3.1 wells/km2,well spacing of 500 m,and row spacing of 650 m.Development practices have confirmed that this scheme is capable of achieving better economic benefits,producing geological reserves as far as possible and improving the ultimate recovery of such gasfields.展开更多
Background:Fever is characterized by an upregulation of the thermoregulatory set-point after the body encounters any pathological challenge.It is accompanied by uncomfortable sickness behaviors and may be harmful in p...Background:Fever is characterized by an upregulation of the thermoregulatory set-point after the body encounters any pathological challenge.It is accompanied by uncomfortable sickness behaviors and may be harmful in patients with other comor-bidities.We have explored the impact of an Ayurvedic medicine,Fevogrit,in an endo-toxin(lipopolysaccharide)-induced fever model in Wistar rats.Methods:Active phytoconstituents of Fevogrit were identified and quantified using ultra-high-performance liquid chromatography(UHPLC)platform.For the in-vivo study,fever was induced in male Wistar rats by the intraperitoneal administration of lipopolysaccharide(LPS),obtained from Escherichia coli.The animals were allocated to normal control,disease control,Paracetamol treated and Fevogrit treated groups.The rectal temperature of animals was recorded at different time points using a digital thermometer.At the 6-h time point,levels of TNF-α,IL-1βand IL-6 cytokines were analyzed in serum.Additionally,the mRNA expression of these cytokines was deter-mined in hypothalamus,24 h post-LPS administration.Results:UHPLC analysis of Fevogrit revealed the presence of picroside I,picroside II,vanillic acid,cinnamic acid,magnoflorine and cordifolioside A,as bioactive constitu-ents with known anti-inflammatory properties.Fevogrit treatment efficiently reduces the LPS-induced rise in the rectal temperature of animals.The levels and gene ex-pression of TNF-α,IL-1βand IL-6 in serum and hypothalamus,respectively,was also significantly reduced by Fevogrit treatment.Conclusion:The findings of the study demonstrated that Fevogrit can suppress LPS-induced fever by inhibiting peripheral or central inflammatory signaling pathways and could well be a viable treatment for infection-induced increase in body temperatures.展开更多
Rauvolfia serpentina(L.)Benth.Ex Kurz is a greatly appreciated medicinal plant,well-known for its therapeutic benefits in traditional medicine,particularly in Ayurveda,where the roots and whole plant are used to treat...Rauvolfia serpentina(L.)Benth.Ex Kurz is a greatly appreciated medicinal plant,well-known for its therapeutic benefits in traditional medicine,particularly in Ayurveda,where the roots and whole plant are used to treat a variety of ailments.However,studies focusing on R.serpentina seeds are relatively scarce.Hence,the present study provides a novel approach by analysing the seed oil of R.serpentina extracted using the supercritical-carbon dioxide-fluid-extraction(SCFE)technique.The research employed advanced analytical methods including gas-chromatography with flame ionization detector(GC-FID),gas-chromatography-tandem mass spectrometry(GC-MS/MS),and high performance thin layer chromatography(HPTLC)to characterise the chemical composition of the extracted oil.Functional moieties were evaluated by Fourier transform infrared spectroscopy(FT-IR),while proton nuclear-magnetic-resonance(1H NMR)spectroscopy was utilised to identify the phytometabolites as well as to assess the physico-chemical parameters.The anti-microbial potential of the supercritically extracted oil was demonstrated through its activity against Klebsiella pneumoniae.The inhibitory effects on K.pneumoniae were quantified using the broth microdilution method,showing activity at both minimum inhibitory concentrations(MIC50 and MIC90).Furthermore,the oil was found to be non-genotoxic,as demonstrated by the Ames assay,which showed no mutagenic effects against S.typhimurium and E.coli WP2 uvrA.Since previous reports on R.serpentina seeds and their novel contribution in the field of pharmaceutics are rather limited,the present study is of utmost importance.The study may pave the way for future investigations into the therapeutic potentials of R.serpentina seeds.展开更多
The use of single and twin-screw extruders for solid-phase reactions is a promising method to intensify a process in a more sustainable manner.In this manuscript,we report a detailed analysis of the residence time dis...The use of single and twin-screw extruders for solid-phase reactions is a promising method to intensify a process in a more sustainable manner.In this manuscript,we report a detailed analysis of the residence time distribution(RTD)in vertical single-screw reactors.The results will help in the selection of the right screw design that would help achieve the desired residence time,which is necessary for a reaction to happen.Experiments were conducted in three vertical screw reactors(having fixed shaft diameter)with varying dimensions using granular free-flowing powders of sodium chloride and silica with a mean particle size of∼25μm.RTD behavior was modeled using the radial particle velocities in the screw reactor's centrifugal field.Further,a method is proposed for estimating the axial dispersion coefficient of dry powders in such sheared flows using true and bulk densities of the powder and the screw shear rate.This dispersion coefficient is used in the axially dispersed plug flow model to describe the RTD behavior of screw reactors with acceptable accuracy.The theoretically predicted and experimentally obtained dispersion coefficients are found to be similar thereby confirming the suitability of the model.展开更多
BACKGROUND Since Japanese national insurance coverage was expanded to include Helicobacter pylori(H.pylori)gastritis in 2013,approximately 1.5 million patients have received eradication therapy annually.However,the pr...BACKGROUND Since Japanese national insurance coverage was expanded to include Helicobacter pylori(H.pylori)gastritis in 2013,approximately 1.5 million patients have received eradication therapy annually.However,the prevalence and clinical features of uninvestigated dyspepsia in the post-eradication era remain unclear.AIM To evaluate the prevalence of dyspepsia and related endoscopic findings in the general population.METHODS We analyzed data from a gastric cancer screening program using esophagogastroduodenoscopy in Sendai city between 2019 and 2021.Data regarding endoscopic findings,upper gastrointestinal symptoms,and history of H.pylori eradication were collected.Dyspepsia was defined as the presence of upper abdominal pain,bloating,or both.Multivariate logistic regression was used to identify independent factors associated with dyspepsia.RESULTS Among 23250 participants,overall dyspepsia prevalence was 28.0%.It was 28.7%in the non-infected and post-eradication cohorts,and lower(25.8%,P<0.05)in the currently infected or naturally eradicated cohort.In addition,23.1%of participants reported heartburn.The following were independently associated with dyspepsia:Age<60 years,female sex,gastric ulcers,duodenal ulcers,erosive esophagitis,a history of gastric surgery,and successful H.pylori eradication.Gastric or esophageal cancer showed no association.CONCLUSION Uninvestigated dyspepsia remains common even after successful H.pylori eradication.Dyspepsia was not considered a reliable indicator of gastric or esophageal cancer.展开更多
AIM:To evaluate parameters measured using the tear film imager(TFI)prototype,a new technology that enables to quantify the tear film thickness of lipid and mucoaqueous layers.METHODS:In this cross-sectional study,pati...AIM:To evaluate parameters measured using the tear film imager(TFI)prototype,a new technology that enables to quantify the tear film thickness of lipid and mucoaqueous layers.METHODS:In this cross-sectional study,patients with dry eye,meibomian gland dysfunction(MGD),and non-dry eye/MGD from February 2020 to January 2021 were analyzed.Quantified TFI outputs included lipid layer thickness(LLT),mucoaqueous layer thickness(MALT),MALT rate of change(MALTR),and lipid breakup time.Two other interferometry devices,LipiView2 and DR-1α,were used for comparison.TFI outputs and other clinical parameters were analyzed using correlation coefficients.Each patient underwent one or several study visits.Baseline values of three device outputs,other clinical parameters,and their changes were examined.RESULTS:This study involved 28 patients(8 patients with dry eyes,13 with MGD,and 7 with non-dry eye/MGD).Baseline TFI,LipiView2,and DR-1αvalues were associated with various clinical parameters.The LLT values estimated using TFI had a correlation with the plugging score in the upper eyelid(r=−0.42).Several TFI values have correlated better than LipiView2 and DR-1α,particularly with questionnaire scores.MALTR by TFI revealed a correlation between standardized patient evaluation on eye dryness(SPEED)and dry eye-related quality of life score(DEQS)scores(r=0.59,0.43),respectively.CONCLUSION:TFI enabled to quantify the LLT and MALT separately over time and shows the moderate correlations between TFI measurements and clinical parameters,which yields the potential for TFI to serve as a complementary tool for assessing dry eye and MGD.展开更多
Enzyme induced carbonate precipitation(EICP)is a promising technique in the field of biocementation due to its efficiency and controllability.Although many studies have proved its reliability in different environment,...Enzyme induced carbonate precipitation(EICP)is a promising technique in the field of biocementation due to its efficiency and controllability.Although many studies have proved its reliability in different environment,little attention has been paid to the influence of humic substances on the EICP.Humic substances cover most of the surface soil across the world land with vegetation,which varies according to the density of vegetation and climate.To understand the compatibility of this technique to distinct problematic soils,it is important to figure out how humic substances could affect the carbonate precipitation process induced by urease enzyme.Therefore,this study aims to investigate the effects of humic acid(HA),one type of humic substance,on the soil solidification through EICP.For this purpose,HA was added to natural soil with varying addition amounts(0%,1%,2%,4%,8%,16%)in soil column solidification tests.The results found that the cementation effectiveness was enhanced by a small amount of HA addition(<4%),while an addition up to 8%greatly inhibited the formation of calcium carbonate.At the same time,soil samples were buffered by HA in a weak acidic condition,thus preventing the emission of undesirable by-product ammonia in the ureolysis process.Therefore,this study makes a contribution to research on enzymatic biocementation by demonstrating the effects of HA on the cementation effectiveness of EICP technique.展开更多
This study quantitatively analyzes the effects of cloud seeding on precipitation and seasonal variations over the Boryeong Dam region,which has the lowest dam storage in South Korea,based on a one-year numerical simul...This study quantitatively analyzes the effects of cloud seeding on precipitation and seasonal variations over the Boryeong Dam region,which has the lowest dam storage in South Korea,based on a one-year numerical simulation for2021.The Morrison microphysics scheme in the WRF(Weather Research and Forecasting)model was modified to estimate differences in precipitation between simulations with seeding materials(Ag I and Ca Cl2;SEED)and without them(UNSD).The effect of cloud seeding on increasing precipitation or artificial rainfall(AR)between the two simulations was highest in August(average:0.21 mm;31%of the SEED-simulated monthly mean)and lowest in January(average:0.003 mm;30%).This large AR may be attributable to a combination of abundant moisture from the summer monsoon climate and enhanced cloud droplet growth resulting from cloud seeding.In the analysis of seasonal representative cases,cloud seeding demonstrated more pronounced effects in spring and summer,with mean 180-min accumulated AR values of 0.46 and 0.43 mm,respectively,within the study area.In the spring,where an actual flight experiment was conducted,the simulated mean180-min accumulated AR(1.41 mm)in the flight experiment area was close to the observed value(1.61 mm)for the same area.Additionally,cloud seeding promoted the hygroscopic growth of water vapor,thereby reducing the cloud water mixing ratio and increasing the rain water mixing ratio.Seasonal cross-sectional analysis further highlighted the impact of cloud seeding on changes in these two mixing ratios,with the most pronounced effects observed in spring and summer.展开更多
Conventional geostress evaluation methods often assume static rock properties and neglect the dynamic degradation of mechanical parameters caused by damage evolution during drilling and fracturing processes,which sign...Conventional geostress evaluation methods often assume static rock properties and neglect the dynamic degradation of mechanical parameters caused by damage evolution during drilling and fracturing processes,which significantly limits prediction accuracy.To address this gap,this study develops a multiphysics-coupled numerical framework integrating COMSOL Multiphysics and MATLAB,grounded in damage mechanics theory,to quantitatively investigate the control mechanism of progressive rock damage on geostress redistribution.By establishing a damage constitutive model coupled with thermo-hydro-mechanical interactions,we simulate the dynamic evolution of rock damage and its impact on stress field reorganization during wellbore operations.Key results demonstrate that(1)incorporating damage evolution leads to substantial deviations in both the magnitude and spatial distribution of geostress,with stress perturbations highly localized within damage zones;(2)changes in mechanical parameters-particularly elastic modulus and permeability-dominate stress adjustments,with heightened sensitivity in formations with low elastic moduli and high permeability;and(3)Poisson's ratio has a negligible influence,whereas permeability variation becomes critically important in low-stiffness formations.Field validation via leakage case analyses in the Wujiaping Formation confirms that the proposed method significantly enhances prediction accuracy compared with conventional approaches.This work elucidates the multiscale interdependency between damage and stress evolution by offering a physics-based framework to optimize drilling and stimulation design in heterogeneous reservoirs.展开更多
Gastric cancer is the second most common of cancerrelated deaths worldwide.In the majority of cases gastric cancer is advanced at diagnosis and although medical and surgical treatments have improved,survival rates rem...Gastric cancer is the second most common of cancerrelated deaths worldwide.In the majority of cases gastric cancer is advanced at diagnosis and although medical and surgical treatments have improved,survival rates remain poor.Cancer immunotherapy has emerged as a powerful and promising clinical approach for treatment of cancer and has shown major success in breast cancer,prostate cancer and melanoma.Here,we provide an overview of concepts of modern cancer immunotherapy including the theory,current approaches,remaining hurdles to be overcome,and the future prospect of cancer immunotherapy in the treatment of gastric cancer.Adaptive cell therapies,cancer vaccines,gene therapies,monoclonal antibody therapies have all been used with some initial successes in gastric cancer.However,to date the results in gastric cancer have been disappointing as current approaches often do not stimulate immunity efficiently allowing tumors continue to grow despite the presence of a measurable immune response.Here,we discuss the identification of targets for immunotherapy and the role of biomarkers in prospectively identifying appropriate subjects or immunotherapy.We also discuss the molecular mechanisms by which tumor cells escape host immunosurveillance and produce an immunosuppressive tumor microenvironment.We show how advances have provided tools for overcoming the mechanisms of immunosuppression including the use of monoclonal antibodies to block negative regulators normally expressed on the surface of T cells which limit activation and proliferation of cytotoxic T cells.Immunotherapy has greatly improved and is becoming an important factor in such fields as medical care and welfare for human being.Progress has been rapid ensuring that the future of immunotherapy for gastric cancer is bright.展开更多
Enteral nutrition has been strongly recommended by major scientific societies for the nutritional management of patients with acute pancreatitis.Providing severe acute pancreatitis patients with enteral nutrition with...Enteral nutrition has been strongly recommended by major scientific societies for the nutritional management of patients with acute pancreatitis.Providing severe acute pancreatitis patients with enteral nutrition within the first 24-48 h of hospital admission can help improve outcomes compared to parenteral nutrition and no feeding.New research is focusing in on when and what to feed to best improve outcomes for acute pancreatitis patients.Early enteral nutrition have the potential to modulate the immune responses.Despite this consistent evidence of early enteral nutrition in patients with acute pancreatitis,clinical practice continues to vary due to individual clinician preference.Achieving the immune modulating effects of enteral nutrition heavily depend on proper placement of the feeding tube and managing any tube feeding associated complications.The current article reviews the immune modulating effects of enteral nutrition and pro-and prebiotics and suggests some practical tools that help improve the patient adherence and tolerance to the tube feeding.Proper selection of the type of the tube,close monitoring of the tube for its placement,patency and securing its proper placement and routine checking the gastric residual volume could all help improve the outcome.Using peptide-based and high medium chaintriglycerides feeding formulas help improving feeding tolerance.展开更多
Objective:To evaluate the antioxidant activity of aqueous extract of Atoringa oleifeta M.oleifera) young leaves by in vivo as well as in vitro assays.Methods:In vitro study included estimation of total phenolic,total ...Objective:To evaluate the antioxidant activity of aqueous extract of Atoringa oleifeta M.oleifera) young leaves by in vivo as well as in vitro assays.Methods:In vitro study included estimation of total phenolic,total ilavonol,total flavonoid and total antioxidant power(FRAP assay).Tn addition, in vivo study was done with the identified most effective dose of 200 nig/kg of its lyophilized powder on normal and diabetic rats.Its effect on different oxidative free radical scavenging enzymes,viz,superoxide dismutase(SOD),catalase(CAT),glutathione-S-transferase(GST),lipid peroxide(LPO) contents were measured.Results:Significant increase in activities of SOD.CAT, GST while,a decrease in LPO content was observed.Whereas,total phenolic,flavonoid and ilavonol contents in the extract were found to be 120 mg/g of CAK,40.5 mg/g of QEK and 12.12 mg/g of QE,respectively.On the other hand.FRAP assay results of M.oleifera leaves was(85.00±5.00)μM of Fe^+/g of extract powder.Conclusions:The significant antioxidant activities of M.oleifera leaves from both in vivo as well as in vitro studies suggests that the regular intake of its leaves through diet can protect normal as well as diabetic patients against oxidative damage.展开更多
基金partly supported a project (JPNP14004) commissioned by the New Energy and Industrial Technology Development Organization (NEDO)the supporting from TOPPAN FORMS CO.,LTD,Japan
文摘In this paper,by proposing a novel and low-cost Ag salt paste,a robustly and large-area(35×35 mm^(2))bare Cu to Cu bonding was realized under a low sintering pressure of 0.8 MPa and a low sintering temperature of 300℃ in air atmospheric conditions.The relationship between the bonding strength and microstructure changes of sintered Ag under various bonding conditions was investigated in detail.The large-area bonded plate exhibits low porosity about 10%and low percentage of voids,which result in ultra-high bonding strength over 58 MPa.More importantly,the introduction of reducing agent formic acid(CH_(2)O_(2))and the low porosity successfully improve the anti-oxidation of novel Ag salt paste during sintering process,result in pure Cu-Ag-Cu bonding.The cross-section of the Ag joints was obtained to explain the bonding pattern,in which Cu was oxidized only at the edge of the sintering interface,and no Cu oxide generated in middle bonding section.The development of novel Ag salt paste successfully addresses the energy-intensive process and low bonding strength faced by large-scale sintering,which greatly promotes the high-temperature applications of power device.
文摘A sodium-cooled fast reactor (SFR) is being developed at the Korea Atomic Energy Research Institute (KAERI). As in-core structural material for a SFR, advanced radiation resistant ODS steel (ARROS) has been developed. This paper summarizes the current status of ARROS development regarding an ODS steel composition, fabrication technology of ODS steel structural components and key joining technologies of ODS steel structural components.
文摘Embryonic stem(ES) cells are isolated from theinner cell mass of a blastocyst, and are used for the generation of gene-modified animals. In mice, the transplantation of gene-modified ES cells into recipient blastocysts leads to the creation of gene-targeted mice such as knock-in and knock-out mice; these gene-targeted mice contribute greatly to scientific development. Although the rat is considered a useful laboratory animal alongside the mouse, fewer genemodified rats have been produced due to the lack of robust establishment methods for rat ES cells. A new method for establishing rat ES cells using signaling inhibitors was reported in 2008. By considering the characteristics of rat ES cells, recent research has made progress in improving conditions for the stable culture of rat ES cells in order to generate gene-modified rats efficiently. In this review, we summarize several advanced methods to maintain rat ES cells and generate gene-targeted rats.
文摘Korea imports about 97% of its energy resources as its available energy resources are extremely limited. Thus, the role of nuclear power in electricity generation is expected to become more important in future years. A fast reactor system is one of the most promising options for electricity generation with an efficient utilization of uranium resources and a reduction of radioactive wastes. Based on the experiences gained during the development of the conceptual designs for KALIMER （Korea advanced liquid metal reactor）, the KAERI （Korea Atomic Energy Research Institute） is currently developing advanced SFR （sodium cooled fast reactor） design concepts that can better meet the Gen IV （Generation IV） technology goals. The long-term advanced SFR development plan will be carried out toward the construction of an advanced SFR demonstration plant by 2028. Advanced concept design studies and the development of the advanced SFR technologies necessary for its commercialization and basic key technologies carried out by KAERI are included in this paper.
文摘SINOPEC has successfully developed a series of hydrogenation technologies aimed at gasoline quality upgrading including pre-hydrotreating of FCC feed and post-hydrotreating of FCC naphtha that are playing a pivotal role for gasoline quality upgrading.It is necessary in the next phase of technical development to carry out an in-depth study on the reaction mechanism,high-activity catalysts,process technology and engineering techniques to further raise the technical level,reduce investment and production cost in a bid to provide technical support for low-cost upgrading of gasoline quality.
基金The Roslin Institute receives Institute Strategic Grant funding from the BBSRC(BB/J004316/1)a studentship from the University of Edinburghfunded by the National Agency for Research and Development (ANID)/Scholarship Program/DOCTORADO BECAS CHILE/2016-72170349.
文摘Background:Impaired reproductive performance is the largest contributing factor for the removal of boars from commercial systems.Intrauterine growth restricted piglets represent 25%of the total number of piglets born and have impaired reproductive performance.This study aimed to improve the understanding of temporal changes in testicular gene expression during testes development in fetuses of different size.The lightest and closest to mean litter weight(CTMLW)male Large White×Landrace littermates were collected at gestational days(GD)45,60 and 90(n=5-6 litters/GD).Results:Testes weight and testes weight as a percentage of fetal weight were not associated with fetal size at GD60 or 90.Fetal plasma testosterone was not associated with fetal size at GD90.There was no association between fetal size and seminiferous tubule area and number,number of germ or Sertoli cells per tubule.The lightest fetuses tended to have wider seminiferous tubules compared to the CTMLW fetuses at GD90(P=0.077).The testicular expression of KI67(P≤0.01)and BAX:BCL2 ratio(P=0.058)mRNAs decreased as gestation progressed.Greater SPP1 mRNA expression was observed at GD60 when compared with GD45 and 90(P≤0.05).Lower expression of DMRT1 and SPP1(P<0.01)mRNAs was observed in testes associated with the lightest fetuses compared to the CTMLW fetuses at GD90.Conclusions:These findings provide novel insights into the expression profiles of genes associated with testicular development and function.Further,these data suggest that programming of reproductive potential in IUGR boars occurs late in gestation,providing a platform for further mechanistic investigation.
文摘Shuttlecock used for badminton is light in mass so that its flight locus is strongly influenced by air. The highest launching velocity of the shuttlecock by professional badminton players exceeds speeds of over 83.3 m/s （300 km/hr）. In this study, a new badminton server machine was developed. The badminton machine can launch the shuttlecocks at wide range of speeds up to 52.8 m/s （190 km/hr） and with many shot types such as smash, clear and so on, which are easily achieved. The finite element models of a shuttlecock with feathers and the badminton machine were made, and the launching simulations of the shuttlecock were tried. The roller with a large diameter attained a higher speed of the shuttlecock than the small rollers for all kinds of launching conditions. The taper angles of the roller edge and the insert height of the shuttlecock relative to the roller surface were optimized for attaining the maximum shuttle speed by the response surface approach. After the optimization, the performance of the badminton machine had been improved about 7% as the shuttle speeds increase and the stress causing the shuttle deterioration decreased.
文摘China has rich deep shale gas resources,which will be an important source for an increase in China’s natural gas production in a certain period in the future.Realizing its large-scale efficient development is of strategic importance in ensuring national energy security.This article analyses and summarizes the opportunities and challenges in China’s scale economy development of shale gas.Opportunities:China’s natural gas market has immense potential,and the prospects for shale gas development are broad;the national and local governments value and support the exploration and development of shale gas;there is a rich resource base that allows for rapid production increase and stable output of deep shale gas;technological advancements will accelerate the pace of scale economy development of deep gas resources.
文摘As a typical tight sandstone gasfield with strong heterogeneity,the Sulige Gas Field in the Ordos Basin faces major challenges in its development because the reservoirs in the gasfield are small in effective sand scale,rapid in lithologic change,strong in plane heterogeneity,and poor in connectivity.How to scientifically deploy development wells to improve the recovery is the most important issue for the successful development of this kind of gasfields.Therefore,a well inference analysis was conducted tofigure out the impact of well pattern density on the recovery based on the research of many years in gasfield development methods and the summary of practical effect.In this paper,we put forward for thefirst time the concept of inter-well interference probability,and present the relationship between the probability of inter-well interference and well pattern density of the Sulige Gas Field.Then we established a mathematical model for the optimization of development well pattern by combiningfine sand anatomy,reservoir engineering,numerical simulation and economic evaluation,and obtained a quantitative relationship between recovery and well pattern density.Furthermore,on the basis of comprehensive analysis,a reasonable development well pattern was designed for the Sulige Gas Field:this well pattern is parallelogram in shape,with a density of 3.1 wells/km2,well spacing of 500 m,and row spacing of 650 m.Development practices have confirmed that this scheme is capable of achieving better economic benefits,producing geological reserves as far as possible and improving the ultimate recovery of such gasfields.
基金This study was supported by internal funds from Patanjali Research Foundation Trust,Haridwar,India。
文摘Background:Fever is characterized by an upregulation of the thermoregulatory set-point after the body encounters any pathological challenge.It is accompanied by uncomfortable sickness behaviors and may be harmful in patients with other comor-bidities.We have explored the impact of an Ayurvedic medicine,Fevogrit,in an endo-toxin(lipopolysaccharide)-induced fever model in Wistar rats.Methods:Active phytoconstituents of Fevogrit were identified and quantified using ultra-high-performance liquid chromatography(UHPLC)platform.For the in-vivo study,fever was induced in male Wistar rats by the intraperitoneal administration of lipopolysaccharide(LPS),obtained from Escherichia coli.The animals were allocated to normal control,disease control,Paracetamol treated and Fevogrit treated groups.The rectal temperature of animals was recorded at different time points using a digital thermometer.At the 6-h time point,levels of TNF-α,IL-1βand IL-6 cytokines were analyzed in serum.Additionally,the mRNA expression of these cytokines was deter-mined in hypothalamus,24 h post-LPS administration.Results:UHPLC analysis of Fevogrit revealed the presence of picroside I,picroside II,vanillic acid,cinnamic acid,magnoflorine and cordifolioside A,as bioactive constitu-ents with known anti-inflammatory properties.Fevogrit treatment efficiently reduces the LPS-induced rise in the rectal temperature of animals.The levels and gene ex-pression of TNF-α,IL-1βand IL-6 in serum and hypothalamus,respectively,was also significantly reduced by Fevogrit treatment.Conclusion:The findings of the study demonstrated that Fevogrit can suppress LPS-induced fever by inhibiting peripheral or central inflammatory signaling pathways and could well be a viable treatment for infection-induced increase in body temperatures.
基金Dr.Anupam Srivastava,Dr.Bhasker Joshi,Patanjali Herbal Research Division for their taxonomical supportsMr.Devendra Kumawat,Patanjali Research Foundation for his help in graphics+1 种基金Mr.Tarun Rajput,Mr.Gagan Kumar for their swift administrative supportsinternal research funds from Patanjali Research Foundation Trust,Haridwar,India.
文摘Rauvolfia serpentina(L.)Benth.Ex Kurz is a greatly appreciated medicinal plant,well-known for its therapeutic benefits in traditional medicine,particularly in Ayurveda,where the roots and whole plant are used to treat a variety of ailments.However,studies focusing on R.serpentina seeds are relatively scarce.Hence,the present study provides a novel approach by analysing the seed oil of R.serpentina extracted using the supercritical-carbon dioxide-fluid-extraction(SCFE)technique.The research employed advanced analytical methods including gas-chromatography with flame ionization detector(GC-FID),gas-chromatography-tandem mass spectrometry(GC-MS/MS),and high performance thin layer chromatography(HPTLC)to characterise the chemical composition of the extracted oil.Functional moieties were evaluated by Fourier transform infrared spectroscopy(FT-IR),while proton nuclear-magnetic-resonance(1H NMR)spectroscopy was utilised to identify the phytometabolites as well as to assess the physico-chemical parameters.The anti-microbial potential of the supercritically extracted oil was demonstrated through its activity against Klebsiella pneumoniae.The inhibitory effects on K.pneumoniae were quantified using the broth microdilution method,showing activity at both minimum inhibitory concentrations(MIC50 and MIC90).Furthermore,the oil was found to be non-genotoxic,as demonstrated by the Ames assay,which showed no mutagenic effects against S.typhimurium and E.coli WP2 uvrA.Since previous reports on R.serpentina seeds and their novel contribution in the field of pharmaceutics are rather limited,the present study is of utmost importance.The study may pave the way for future investigations into the therapeutic potentials of R.serpentina seeds.
基金funding from CSIR(MLP100926)and SERB(DST,Govt.of India)(CRG//2023/001897-G)for this work.
文摘The use of single and twin-screw extruders for solid-phase reactions is a promising method to intensify a process in a more sustainable manner.In this manuscript,we report a detailed analysis of the residence time distribution(RTD)in vertical single-screw reactors.The results will help in the selection of the right screw design that would help achieve the desired residence time,which is necessary for a reaction to happen.Experiments were conducted in three vertical screw reactors(having fixed shaft diameter)with varying dimensions using granular free-flowing powders of sodium chloride and silica with a mean particle size of∼25μm.RTD behavior was modeled using the radial particle velocities in the screw reactor's centrifugal field.Further,a method is proposed for estimating the axial dispersion coefficient of dry powders in such sheared flows using true and bulk densities of the powder and the screw shear rate.This dispersion coefficient is used in the axially dispersed plug flow model to describe the RTD behavior of screw reactors with acceptable accuracy.The theoretically predicted and experimentally obtained dispersion coefficients are found to be similar thereby confirming the suitability of the model.
文摘BACKGROUND Since Japanese national insurance coverage was expanded to include Helicobacter pylori(H.pylori)gastritis in 2013,approximately 1.5 million patients have received eradication therapy annually.However,the prevalence and clinical features of uninvestigated dyspepsia in the post-eradication era remain unclear.AIM To evaluate the prevalence of dyspepsia and related endoscopic findings in the general population.METHODS We analyzed data from a gastric cancer screening program using esophagogastroduodenoscopy in Sendai city between 2019 and 2021.Data regarding endoscopic findings,upper gastrointestinal symptoms,and history of H.pylori eradication were collected.Dyspepsia was defined as the presence of upper abdominal pain,bloating,or both.Multivariate logistic regression was used to identify independent factors associated with dyspepsia.RESULTS Among 23250 participants,overall dyspepsia prevalence was 28.0%.It was 28.7%in the non-infected and post-eradication cohorts,and lower(25.8%,P<0.05)in the currently infected or naturally eradicated cohort.In addition,23.1%of participants reported heartburn.The following were independently associated with dyspepsia:Age<60 years,female sex,gastric ulcers,duodenal ulcers,erosive esophagitis,a history of gastric surgery,and successful H.pylori eradication.Gastric or esophageal cancer showed no association.CONCLUSION Uninvestigated dyspepsia remains common even after successful H.pylori eradication.Dyspepsia was not considered a reliable indicator of gastric or esophageal cancer.
基金Supported by Topcon Corporation and Santen Pharmaceutical Co.Ltd.
文摘AIM:To evaluate parameters measured using the tear film imager(TFI)prototype,a new technology that enables to quantify the tear film thickness of lipid and mucoaqueous layers.METHODS:In this cross-sectional study,patients with dry eye,meibomian gland dysfunction(MGD),and non-dry eye/MGD from February 2020 to January 2021 were analyzed.Quantified TFI outputs included lipid layer thickness(LLT),mucoaqueous layer thickness(MALT),MALT rate of change(MALTR),and lipid breakup time.Two other interferometry devices,LipiView2 and DR-1α,were used for comparison.TFI outputs and other clinical parameters were analyzed using correlation coefficients.Each patient underwent one or several study visits.Baseline values of three device outputs,other clinical parameters,and their changes were examined.RESULTS:This study involved 28 patients(8 patients with dry eyes,13 with MGD,and 7 with non-dry eye/MGD).Baseline TFI,LipiView2,and DR-1αvalues were associated with various clinical parameters.The LLT values estimated using TFI had a correlation with the plugging score in the upper eyelid(r=−0.42).Several TFI values have correlated better than LipiView2 and DR-1α,particularly with questionnaire scores.MALTR by TFI revealed a correlation between standardized patient evaluation on eye dryness(SPEED)and dry eye-related quality of life score(DEQS)scores(r=0.59,0.43),respectively.CONCLUSION:TFI enabled to quantify the LLT and MALT separately over time and shows the moderate correlations between TFI measurements and clinical parameters,which yields the potential for TFI to serve as a complementary tool for assessing dry eye and MGD.
基金JST SPRING,Grant Number JPMJSP2119Japan Society for the Promotion of Science(JSPS)KAKENHI Grant Number JP22H01581。
文摘Enzyme induced carbonate precipitation(EICP)is a promising technique in the field of biocementation due to its efficiency and controllability.Although many studies have proved its reliability in different environment,little attention has been paid to the influence of humic substances on the EICP.Humic substances cover most of the surface soil across the world land with vegetation,which varies according to the density of vegetation and climate.To understand the compatibility of this technique to distinct problematic soils,it is important to figure out how humic substances could affect the carbonate precipitation process induced by urease enzyme.Therefore,this study aims to investigate the effects of humic acid(HA),one type of humic substance,on the soil solidification through EICP.For this purpose,HA was added to natural soil with varying addition amounts(0%,1%,2%,4%,8%,16%)in soil column solidification tests.The results found that the cementation effectiveness was enhanced by a small amount of HA addition(<4%),while an addition up to 8%greatly inhibited the formation of calcium carbonate.At the same time,soil samples were buffered by HA in a weak acidic condition,thus preventing the emission of undesirable by-product ammonia in the ureolysis process.Therefore,this study makes a contribution to research on enzymatic biocementation by demonstrating the effects of HA on the cementation effectiveness of EICP technique.
基金funded by the Korea Meteorological Administration Research and Development Program“Research on Weather Modification and Cloud Physics”(Grant No.KMA2018-00224)supported by Korea Institute of Marine Science&Technology Promotion(KIMST)funded by the Ministry of Oceans and Fisheries,Korea(RS-202502217872)supported by an NRF grant funded by the Korean government(MSIT)(Grant No.NRF2023R1A2C1002367)。
文摘This study quantitatively analyzes the effects of cloud seeding on precipitation and seasonal variations over the Boryeong Dam region,which has the lowest dam storage in South Korea,based on a one-year numerical simulation for2021.The Morrison microphysics scheme in the WRF(Weather Research and Forecasting)model was modified to estimate differences in precipitation between simulations with seeding materials(Ag I and Ca Cl2;SEED)and without them(UNSD).The effect of cloud seeding on increasing precipitation or artificial rainfall(AR)between the two simulations was highest in August(average:0.21 mm;31%of the SEED-simulated monthly mean)and lowest in January(average:0.003 mm;30%).This large AR may be attributable to a combination of abundant moisture from the summer monsoon climate and enhanced cloud droplet growth resulting from cloud seeding.In the analysis of seasonal representative cases,cloud seeding demonstrated more pronounced effects in spring and summer,with mean 180-min accumulated AR values of 0.46 and 0.43 mm,respectively,within the study area.In the spring,where an actual flight experiment was conducted,the simulated mean180-min accumulated AR(1.41 mm)in the flight experiment area was close to the observed value(1.61 mm)for the same area.Additionally,cloud seeding promoted the hygroscopic growth of water vapor,thereby reducing the cloud water mixing ratio and increasing the rain water mixing ratio.Seasonal cross-sectional analysis further highlighted the impact of cloud seeding on changes in these two mixing ratios,with the most pronounced effects observed in spring and summer.
基金supported by Science Project of PetroChina Southwest Oil&Gas field Company,China(Grant.No:2024D112-01-02).
文摘Conventional geostress evaluation methods often assume static rock properties and neglect the dynamic degradation of mechanical parameters caused by damage evolution during drilling and fracturing processes,which significantly limits prediction accuracy.To address this gap,this study develops a multiphysics-coupled numerical framework integrating COMSOL Multiphysics and MATLAB,grounded in damage mechanics theory,to quantitatively investigate the control mechanism of progressive rock damage on geostress redistribution.By establishing a damage constitutive model coupled with thermo-hydro-mechanical interactions,we simulate the dynamic evolution of rock damage and its impact on stress field reorganization during wellbore operations.Key results demonstrate that(1)incorporating damage evolution leads to substantial deviations in both the magnitude and spatial distribution of geostress,with stress perturbations highly localized within damage zones;(2)changes in mechanical parameters-particularly elastic modulus and permeability-dominate stress adjustments,with heightened sensitivity in formations with low elastic moduli and high permeability;and(3)Poisson's ratio has a negligible influence,whereas permeability variation becomes critically important in low-stiffness formations.Field validation via leakage case analyses in the Wujiaping Formation confirms that the proposed method significantly enhances prediction accuracy compared with conventional approaches.This work elucidates the multiscale interdependency between damage and stress evolution by offering a physics-based framework to optimize drilling and stimulation design in heterogeneous reservoirs.
基金Supported by Research Center for Innovative Cancer Therapy,Cancer Vaccine Development Division,Kurume University to Matsueda Sin part by the Office of Research and Development Medical Research Service Department of Veterans Affairs,Public Health Service grants DK067366 and DK56338 which funds the Texas Medical Center Digestive Diseases Center to Graham DY
文摘Gastric cancer is the second most common of cancerrelated deaths worldwide.In the majority of cases gastric cancer is advanced at diagnosis and although medical and surgical treatments have improved,survival rates remain poor.Cancer immunotherapy has emerged as a powerful and promising clinical approach for treatment of cancer and has shown major success in breast cancer,prostate cancer and melanoma.Here,we provide an overview of concepts of modern cancer immunotherapy including the theory,current approaches,remaining hurdles to be overcome,and the future prospect of cancer immunotherapy in the treatment of gastric cancer.Adaptive cell therapies,cancer vaccines,gene therapies,monoclonal antibody therapies have all been used with some initial successes in gastric cancer.However,to date the results in gastric cancer have been disappointing as current approaches often do not stimulate immunity efficiently allowing tumors continue to grow despite the presence of a measurable immune response.Here,we discuss the identification of targets for immunotherapy and the role of biomarkers in prospectively identifying appropriate subjects or immunotherapy.We also discuss the molecular mechanisms by which tumor cells escape host immunosurveillance and produce an immunosuppressive tumor microenvironment.We show how advances have provided tools for overcoming the mechanisms of immunosuppression including the use of monoclonal antibodies to block negative regulators normally expressed on the surface of T cells which limit activation and proliferation of cytotoxic T cells.Immunotherapy has greatly improved and is becoming an important factor in such fields as medical care and welfare for human being.Progress has been rapid ensuring that the future of immunotherapy for gastric cancer is bright.
文摘Enteral nutrition has been strongly recommended by major scientific societies for the nutritional management of patients with acute pancreatitis.Providing severe acute pancreatitis patients with enteral nutrition within the first 24-48 h of hospital admission can help improve outcomes compared to parenteral nutrition and no feeding.New research is focusing in on when and what to feed to best improve outcomes for acute pancreatitis patients.Early enteral nutrition have the potential to modulate the immune responses.Despite this consistent evidence of early enteral nutrition in patients with acute pancreatitis,clinical practice continues to vary due to individual clinician preference.Achieving the immune modulating effects of enteral nutrition heavily depend on proper placement of the feeding tube and managing any tube feeding associated complications.The current article reviews the immune modulating effects of enteral nutrition and pro-and prebiotics and suggests some practical tools that help improve the patient adherence and tolerance to the tube feeding.Proper selection of the type of the tube,close monitoring of the tube for its placement,patency and securing its proper placement and routine checking the gastric residual volume could all help improve the outcome.Using peptide-based and high medium chaintriglycerides feeding formulas help improving feeding tolerance.
基金National Medicinal Plants Board. Govt,of India,New Delhi,India for providing financial assistance in the form of Senior Research Fellowship to cam' out the present study
文摘Objective:To evaluate the antioxidant activity of aqueous extract of Atoringa oleifeta M.oleifera) young leaves by in vivo as well as in vitro assays.Methods:In vitro study included estimation of total phenolic,total ilavonol,total flavonoid and total antioxidant power(FRAP assay).Tn addition, in vivo study was done with the identified most effective dose of 200 nig/kg of its lyophilized powder on normal and diabetic rats.Its effect on different oxidative free radical scavenging enzymes,viz,superoxide dismutase(SOD),catalase(CAT),glutathione-S-transferase(GST),lipid peroxide(LPO) contents were measured.Results:Significant increase in activities of SOD.CAT, GST while,a decrease in LPO content was observed.Whereas,total phenolic,flavonoid and ilavonol contents in the extract were found to be 120 mg/g of CAK,40.5 mg/g of QEK and 12.12 mg/g of QE,respectively.On the other hand.FRAP assay results of M.oleifera leaves was(85.00±5.00)μM of Fe^+/g of extract powder.Conclusions:The significant antioxidant activities of M.oleifera leaves from both in vivo as well as in vitro studies suggests that the regular intake of its leaves through diet can protect normal as well as diabetic patients against oxidative damage.
