The mechanistic target of rapamycin(m TOR) is a serine/threonine kinase that plays a pivotal role in cellular growth, proliferation, survival, and metabolism. In the central nervous system(CNS), the mTOR pathway regul...The mechanistic target of rapamycin(m TOR) is a serine/threonine kinase that plays a pivotal role in cellular growth, proliferation, survival, and metabolism. In the central nervous system(CNS), the mTOR pathway regulates diverse aspects of neural development and function. Genetic mutations within the m TOR pathway lead to severe neurodevelopmental disorders, collectively known as “mTORopathies”(Crino, 2020). Dysfunctions of m TOR, including both its hyperactivation and hypoactivation, have also been implicated in a wide spectrum of other neurodevelopmental and neurodegenerative conditions, highlighting its importance in CNS health.展开更多
China aims to build on its achievements of the past five years to accelerate rural revitalization during the 15th Five-Year Plan period.IN China,issues relating to agriculture,rural areas,and rural residents have alwa...China aims to build on its achievements of the past five years to accelerate rural revitalization during the 15th Five-Year Plan period.IN China,issues relating to agriculture,rural areas,and rural residents have always been a priority in national development.At its fourth plenary session held in October 2025,the 20th Central Committee of the Communist Party of China(CPC)once again emphasized the need to accelerate agricultural and rural modernization,and advance all-around rural revitalization over the next five years.展开更多
Each spring,China’s largest political gathering,the Two Sessions,brings together the National People’s Congress and the National Committee of the Chinese People’s Political Consultative Conference to set the nation...Each spring,China’s largest political gathering,the Two Sessions,brings together the National People’s Congress and the National Committee of the Chinese People’s Political Consultative Conference to set the nation’s broad policy direction for the year.展开更多
The year 2026 marks the 70th anniversary of the establishment of diplomatic relations between China and African countries.It also marks the launch of the China-Africa Year of People-to-People Exchanges.At this pivotal...The year 2026 marks the 70th anniversary of the establishment of diplomatic relations between China and African countries.It also marks the launch of the China-Africa Year of People-to-People Exchanges.At this pivotal juncture linking past achievements with future development,Wang Yi,member of the Political Bureau of the Communist Party of China Central Committee and foreign minister,continued the longstanding diplomatic tradition under which the Chinese foreign minister makes Africa the destination of the first overseas visit of the year,a practice upheld for 36 consecutive years,underscoring the stability,continuity and sincerity of China’s policy towards Africa.展开更多
The shale gas development in China faces challenges such as complex reservoir conditions and high development costs.Based on the pore pressure and geostress coupling theory,this paper studies the geostress evolution l...The shale gas development in China faces challenges such as complex reservoir conditions and high development costs.Based on the pore pressure and geostress coupling theory,this paper studies the geostress evolution laws and fracture network characteristics of shale gas infill wells.A mechanism model of CN platform logging data and geomechanical parameters is established to simulate the influence of parent well’s production on the geostress in the infill well area.It is suggested that with the increase of production time,normal fault stress state and horizontal stress deflection will occur.The smaller the parent well spacing and the longer the production time,the earlier the normal fault stress state appears and the larger the range.Based on the model,the fracture network morphology and construction parameters of infill wells are optimized.parentparentparentparent The results indicate that:1:A well spacing of 500 m achieves a Pareto optimum between“full reserve coverage”and“stress barrier”;2:A parent well recovery degree of 30%corresponds to the critical point of stress reversal,where the lateral deflection rate of the infill fracture is less than 8%and the SRV loss is minimized;3:6-cluster intensive completion with twice the liquid intensity increases the fracture complexity index by 1.7 times,enhances well group EUR by 15.4%,and reduces single-well cost by 22%.This research fills the theoretical gap in the collaborative optimization of“multi-parameter,multi-objective and multi-constraint”and provide parameter optimization basis for shale gas infill well development in China and help to improve the development efficiency and economic benefits.展开更多
In the complex architecture of global value-chain(GVC)trade,firms’technological content increasingly reflects external knowledge flows.This study examines how inter-regional technological complementarity shapes firms...In the complex architecture of global value-chain(GVC)trade,firms’technological content increasingly reflects external knowledge flows.This study examines how inter-regional technological complementarity shapes firms’GVC advancement,measured by the domestic value-added rate(DVAR)in exports.Using integrated Chinese microdata(2000-2014),we find this complementarity significantly boosts export DVAR,explaining about one-quarter of its observed growth.Two mechanisms drive this effect:increased use of domestic intermediates and gains in firm productivity.The benefits are especially large for firms with lower human capital and for those in accessible,innovation-peripheral regions,helping narrow productivity gaps across firms and space.Affected firms also exhibit broader export scopes,higher product quality,more diversified destinations,and greater markups-firm-level evidence of GVC upgrading.These findings highlight how external technological linkages drive upgrading and underscore the importance of fostering inter-regional synergies for balanced development.展开更多
County-to-district conversion(CDC) has restructured the pattern of urban-rural development and influenced the allocation of resources by local governments as well as the urbanization process.However,the impact and mec...County-to-district conversion(CDC) has restructured the pattern of urban-rural development and influenced the allocation of resources by local governments as well as the urbanization process.However,the impact and mechanism of the CDC on China's urban-rural integration development(URID) are not yet clear.Using panel data from 52 county-level cities,districts,and counties in Jiangsu Province of China during 2005–2021,this paper constructed an evaluation system for URID and applied the multi-period difference-in-differences(DID) model to measure the impact of the CDC on URID and identify its primary mechanisms of action.The results demonstrated that the CDC has significantly fostered URID,though with pronounced regional heterogeneity.Specifically,while the CDC facilitated URID in the southern and central Jiangsu Province—regions characterized by high socio-economic development—it exerted a less significant impact in the comparatively underdeveloped northern Jiangsu Province.Mechanistically,the implementation of the CDC promotes equal regional development,enhances rural selfdevelopment capacity,improves environmental quality and living standards,and optimizes urban-rural land allocation and transport networks.Ultimately,this study clarifies the role of the CDC in China,provides insights for achieving URID,and offers a reference for other countries pursuing coordinated urban-rural development.展开更多
For the first three decades of the 21st century,the United Nations(UN)guided global development through two successive agendas:the Millennium Development Goals(MDGs)and the Sustainable Development Goals(SDGs),each spa...For the first three decades of the 21st century,the United Nations(UN)guided global development through two successive agendas:the Millennium Development Goals(MDGs)and the Sustainable Development Goals(SDGs),each spanning 15 years.When the MDGs concluded in 2015,the 17 SDGs introduced a new vision for humanity,providing a framework for addressing global challenges and shaping international cooperation.Over the past decade.展开更多
Centering on the critical bottlenecks in the development of shale oil in the Jiyang Depression of Shengli Oilfield,key scientific and engineering issues are proposed in aspects such as the storage space and occurrence...Centering on the critical bottlenecks in the development of shale oil in the Jiyang Depression of Shengli Oilfield,key scientific and engineering issues are proposed in aspects such as the storage space and occurrence state of shale oil,the formation mechanisms of multi-scale flow spaces,the mobilization mechanisms of crude oil in pores and fractures,and the enhanced oil recovery(EOR)mechanisms during the late stage of elastic development.The research progress and mechanistic insights in recent years are reviewed with respect to experimental techniques,characteristics of pore-fracture structure and fluid occurrence,fracture evolution mechanisms,shale oil flow mechanisms and EOR techniques.Through improving the experimental methods,optimizing the testing conditions,and developing new technologies,we deeply understand the occurrence state,storage space and flow pattern of shale oil,and reveal the distribution pattern of“oil-bearing in all pore sizes and oil-rich in large pores”and the differences in fluid phase states under the confinement effect of nano-scale pores in the shales of the Jiyang Depression;depict the characteristics of“restricted vertical expansion and complex fracture networks”of induced fractures and the dynamic evolution of fracture networks during the fracturing-soaking-production process;establish a“easy flow-slow flow-stagnant flow”three-zone model and the elastic drive+imbibition drive synergistic energy replenishment mechanism;and carry out high-pressure injection to further enhance the mass transfer and diffusion capacity of CO_(2)within the shale pore-fracture system,and compete for the desorption of alkanes to improve the mobilization degree of shale oil.The research achievements provide crucial support for the formation of the theory of continental shale oil development and the construction of the technical system.The future research efforts will focus on mine-scale multi-field coupling physical simulation equipment,microscopic to macroscopic multi-scale experimental methods,pore/fracture fine characterization and post-fracturing core fracture description technologies,multi-media fluid-structure coupling numerical simulation algorithms,and low-cost EOR and low-quality shale oil in-situ upgrading technologies,in order to promote the large-scale and profitable development of shale oil in the Jiyang Depression.展开更多
Unmanned combat aerial vehicles require lightweight,stealth-capable exhaust systems.However,traditional metallic nozzles increase radar detectability and reduce range,while advanced composites offer high performance b...Unmanned combat aerial vehicles require lightweight,stealth-capable exhaust systems.However,traditional metallic nozzles increase radar detectability and reduce range,while advanced composites offer high performance but are expensive.Therefore,to improve the operational range and survivability of unmanned combat aerial vehicles,a lightweight,high-temperature-resistant,oxidation-resistant,and low-observable composite exhaust nozzle is developed to replace conventional metallic straight-type nozzles.The nozzle features a double serpentine shape to reduce radar and infrared signatures and is manufactured as a monolithic structure using the filament winding process,accommodating the complex geometry and large size(length:1.8 m,width:0.8 m).The exhaust nozzle consists of a ceramic matrix composite made of silicon carbide fibers and a silicon oxycarbide matrix,which absorbs and scatters radio frequency signals while withstanding prolonged exposure to high-temperature(700℃)oxidizing environments typical of engine exhaust gases.The polysiloxane resin used to produce the silicon oxycarbide matrix poses significant challenges owing to its low tackiness and high viscosity variations depending on the presence of nanoparticles,making filament winding difficult.These challenges are addressed by optimizing resin viscosity and winding pattern design.As a result,the tensile strength of the composite specimens fabricated with the optimized viscosity increases by 228.03% before pyrolysis and 97.68%after pyrolysis,compared with that of the non-optimized specimens.In addition,the density and tensile strength of the composite processed via three cycles of polymer infiltration and pyrolysis increased by 13.08% and 80.37%,respectively,compared to those of the non-densified composite.High-temperature oxidation and flame tests demonstrate exceptional thermal and oxidative stability.Furthermore,when compared with carbon fiber-reinforced ceramic matrix composites,the developed composite exhibits a permittivity at least two levels lower and a reflection loss below7 dB within the frequency range of 9.3-10.9 GHz,underscoring its superior electromagnetic stealth performance.展开更多
The vertical heterogeneity of the pore structure in deep coal seams with varying ash yields is a key control for coalbed methane storage and producibility;however,its specific impact on gas adsorption is not clearly d...The vertical heterogeneity of the pore structure in deep coal seams with varying ash yields is a key control for coalbed methane storage and producibility;however,its specific impact on gas adsorption is not clearly defined.The focus of this study is the No.8 coal seam of the Carboniferous Benxi Formation in the Central-Eastern Ordos Basin.By integrating microscopic identification,proximate analysis,gas adsorption(CO_(2),N_(2),and CH_(4)),and the multifractal theory,we quantitatively characterized the nanopore structure(micropores<2 nm and mesopores 2 nm-100 nm)of coal reservoirs with varying ash yields.The results indicate that(1)ash yield is the primary factor that controls the vertical evolution of pore structures in coal seams.In low-ash yield coal seams,the extent of thermal evolution and ash yield jointly constrain the heterogeneity of pore size distribution.In mediumto high-ash yield coal seams,the heterogeneity of pore structure and pore size distribution are predominantly constrained by ash yield.(2)As the ash yield vertically increases,the mesoporous pore volume and specific surface area initially decrease and subsequently increase,while the contribution of micropores to both pore volume and specific surface area continuously diminishes.Consequently,the total pore volume and specific surface area of the coal samples exhibit a two-stage reduction close to an ash yield threshold of approximately 20%.(3)Further,the Langmuir volume for CH_(4)adsorption sharply declines below the 20%threshold,followed by a gradual decrease;in contrast,the Langmuir pressure initially decreases and subsequently increases.Hence,the vertical increase in ash yield constrains the development of pore systems and diminishes pore connectivity,thereby reducing methane adsorption capacity and adversely affecting coalbed methane productivity.(4)Low-ash yield coal reservoirs are characterized by a rapid gas breakthrough and high productivity,whereas medium-ash yield coal reservoirs generally require prolonged depressurization to achieve peak gas production.These findings reveal that in medium-high rank coal,ash yield―and not thermal evolution―is the main factor that controls vertical pore evolution and methane adsorption efficiency.The quantitative ash yield threshold(20%)established in this study provides a practical criterion for evaluating reservoir quality and predicting vertical variations in gas storage potential in the Ordos Basin.展开更多
Hearing and balance disorders are significant health issues primarily caused by developmental defects or the irreversible loss of sensory hair cells(HCs).ldentifying the underlying genes involved in the morphogenesis ...Hearing and balance disorders are significant health issues primarily caused by developmental defects or the irreversible loss of sensory hair cells(HCs).ldentifying the underlying genes involved in the morphogenesis and development of HCs is crucial.Our current study highlights rhpn2,a member of rho-binding proteins,as essential for vestibular HC development.The rhpn2 gene is highly expressed in the crista and macula HCs.Loss of rhpn2 function in zebrafish reduces the otic vesicle area and vestibular HC number,accompanied by vestibular dysfunction.Shorter stereocilia and compromised mechanotransduction channel function are found in the crista HCs of rhpn2 mutants.Transcriptome RNA sequencing analysis predicts the potential interaction of rhpn2 with rhoab.Furthermore,co-immunoprecipitation confirms that Rhpn2 directly binds to RhoA,validating the interaction of the two proteins.rhpn2 knockout leads to a decreased expression of rock2b,a canonical RhoA signaling pathway gene.Treatment with the RhoA activator or exogenous rock2b mRNA injection mitigates crista HC stereocilia defects in rhpn2 mutants.This study uncovers the role of rhpn2 in vestibular HC development and stereocilia formation via mediating the RhoA signaling pathway,providing a target for the treatment of balance disorders.展开更多
The available heat content (stored heat energy) of hot dry rock (HDR) at a depth of 1–10 km in the global land crust is estimated to be 5.06×10~8 EJ,attracting considerable global attention.This paper presents a...The available heat content (stored heat energy) of hot dry rock (HDR) at a depth of 1–10 km in the global land crust is estimated to be 5.06×10~8 EJ,attracting considerable global attention.This paper presents a comprehensive analysis of the geological framework,HDR resource potential,exploration advancements,and the development of enhanced geothermal systems (EGSs) in China.HDR resources are extensively distributed across China.Within the depth range of 3–10 km,China’s estimated potential approximates2.29×10~7 EJ,with a theoretical power generation capacity of approximately 1.67×10^(16) k Wh.Replacing coal power with HDR can help to achieve a net emission reduction of 1.34×10^(16) kg CO_(2) (approximately1.34×10^(13) t),representing an emission reduction efficiency of 94.4%.Based on a development cycle of100 years,the average annual emission reduction reaches 1.34×10^(10) t CO_(2),equivalent to 117%of China’s annual carbon emissions in 2022.Furthermore,in the context of global warming,the development and utilization of HDR,which is feasible in virtually any region worldwide,offers significant potential to support global carbon reduction efforts.China has made substantial progress in HDR exploration in recent years.This paper systematically classifies China’s HDR resources into four genetic types—highly radioactive heat-producing,sedimentary basin,active volcanic,and intensely tectonic zones—and offers detailed exploration insights for each category.Each classification exhibits distinct geological and tectonic characteristics that influence heat source mechanisms and resource distribution.Furthermore,this paper documents significant advances in EGS construction,particularly in the Gonghe Basin on the northeastern margin of the Qianghai-Xizang Plateau and the Matouying uplift in the North China Basin,where successful reservoir stimulation,microseismic monitoring,and experimental power generation have been achieved.Despite these developments,challenges persist,including technical adaptability under complex geological conditions and the economic viability of large-scale HDR development.This paper suggests that future initiatives should emphasize resource exploration,technological research,and policy support to foster sustainable HDR resource development in China,thereby contributing to the global energy transition and environmental sustainability.展开更多
The arginine-phenylalanine-amide neuropeptide receptor family comprises a subclass within the G protein-coupled receptor superfamily with crucial roles in physiological regulation.These receptors recognize and bind ne...The arginine-phenylalanine-amide neuropeptide receptor family comprises a subclass within the G protein-coupled receptor superfamily with crucial roles in physiological regulation.These receptors recognize and bind neuropeptides with an arginine-phenylalanine-amide motif,thereby participating in a variety of biological processes such as energy metabolism,pain perception,and reproductive functions.In this review,we explore the physiological and pathological processes involving these receptors and delve into the structure-activity relationships of their ligand peptides,clarifying the key structural motifs within these neuropeptides that determine their biological activity,pharmacological potency,and receptor selectivity.Particular emphasis is placed on their roles in modulating nociception,regulating appetite,and maintaining reproductive health.Additionally,we discuss the therapeutic potential of structure-based drug design targeting these receptors based on existing cryo-electron microscopy structures.The available structural insights into ligand-binding pockets and G protein-receptor interaction interfaces provide a clear perspective and valuable complement to ligand optimization.展开更多
Recent advancements in developing tannin-based non-isocyanate polyurethane(NIPU)resins have unlocked new possibilities for sustainable and eco-friendly wood adhesives.Unlike conventional polyurethane,NIPUs eliminate h...Recent advancements in developing tannin-based non-isocyanate polyurethane(NIPU)resins have unlocked new possibilities for sustainable and eco-friendly wood adhesives.Unlike conventional polyurethane,NIPUs eliminate hazardous isocyanates,offering safer alternatives for industrial applications.Tannin,a naturally occurring polyphenolic compound,plays a pivotal role in enhancing these resins’fire-resistance and super-hydrophobic properties.This review highlights key developments in synthesizing tannin-based NIPU,focusing on various polymerization techniques such as polyaddition,polycondensation,ring-opening polymerization,and rearrangement.These strategies contribute to improved mechanical strength,thermal stability,and resistance to water absorption.Recent studies demonstrate that tannin-based NIPU adhesives meet or exceed international internal bonding strength,elasticity,and durability standards.Their application in wood-based composites like oriented strand boards(OSB)has shown promising results,offering improved resistance to moisture and superior dimensional stability.Furthermore,the cross-linked polymer network,supported by chemical modifications like the introduction of fluoroalkyl groups,significantly enhances hydrophobicity and fire retardancy.Despite these advancements,challenges remain in terms of scalability,cost,and integration with existing manufacturing processes.Future research should focus on optimizing reaction conditions,improving raw material availability,and developing industrial-scale production methods.This review underscores the potential of tannin-based NIPU resins as a viable and sustainable alternative for various wood composite applications.展开更多
Objectives:Bladder cancer(BCa)progression is closely linked to the immune microenvironment.However,the key molecules that regulate this microenvironment and their specific mechanisms remain poorly understood.This stud...Objectives:Bladder cancer(BCa)progression is closely linked to the immune microenvironment.However,the key molecules that regulate this microenvironment and their specific mechanisms remain poorly understood.This study aims to identify a key molecule and elucidate its mechanisms,providing a theoretical basis for identifying novel therapeutic targets.Methods:Immune microenvironment-related genes in BCa were identified using The Cancer Genome Atlas and Shanghai Tenth People’s Hospital datasets.Proteasome 26S subunit non-ATPase 2(PSMD2)expression was validated via quantitative polymerase chain reaction(qPCR),Western blot(WB)analysis,and immunofluorescence(IF).In vitro and in vivo experiments confirmed the role of PSMD2 in cell proliferation,invasion,and migration.Kyoto encyclopedia of genes and genomes(KEGG)and Gene Ontology(GO)analyses were conducted to assess PSMD2’s influence on immune microenvironment remodeling.A pathomics model predicted PSMD2 expression in patients with BCa.Results:PSMD2 was identified as a critical factor in BCa,with high expression correlating with poor prognosis and tumor progression.Mechanistically,PSMD2 enhances malignancy by promoting mitogen-activated protein kinase kinase(MEK)and extracellular signal-regulated kinase(ERK)phosphorylation within the mitogen-activated protein kinase(MAPK)signaling pathway.Combined bioinformatics and experimental analyses reveal that PSMD2 downregulates chemokine(C-X-C motif)ligand 14(CXCL14)expression and secretion via the MAPK pathway,thereby remodeling the immune microenvironment and driving tumor progression.Pathomics analysis further supports the potential of PSMD2 expression as a predictive marker in BCa tissues.Conclusion:PSMD2 is overexpressed in BCa and significantly correlates with poor prognosis and tumor progression.It promotes malignant development and immune microenvironment remodeling through the MAPK pathway.Pathological analysis can predict PSMD2 expression,offering valuable insights into immunotherapy responses and survival outcomes.展开更多
Metastatic brain tumors undergo profound metabolic-epigenetic reprogramming driven by the unique constraints of the brain microenvironment.Hypoxia-inducible factor-1α(HIF1α)enhances glycolytic flux,lactate accumulat...Metastatic brain tumors undergo profound metabolic-epigenetic reprogramming driven by the unique constraints of the brain microenvironment.Hypoxia-inducible factor-1α(HIF1α)enhances glycolytic flux,lactate accumulation,and histone lactylation,collectively supporting metastatic colonization and immune evasion.Key metabolites including acetyl-CoA,S-adenosylmethionine(SAM),α-ketoglutarate(α-KG),fumarate,and 2-hydroxyglutarate(2-HG)-directly modify chromatin states by regulating histone acetyltransferases,DNA/histone methyltransferases,andα-KG dependent dioxygenases such as Ten-Eleven Translocation(TET)enzymes and lysine demethylases(KDMs).These metabolic shifts result in aberrant DNA methylation,histone lysine residue at position 27 on Histone H3(H3K27)trimethylation,and depletion of 5-hydroxymethylcytosine(5hmC),all of which are hallmark epigenetic alterations in brain metastasis and primary Central Nervous System(CNS)tumors.Additionally,the blood-brain barrier(BBB)and blood-tumor barrier(BTB)impose nutrient restrictions and induce metabolic dependency on glutamine,acetate,and lactate shuttling,thereby reshaping epigenetic enzyme activity.We synthesize current mechanistic evidence showing how metabolic pressures in the brain microenvironment remodel the epigenome to promote tumor plasticity,stemness,and therapeutic resistance.Understanding these coupled pathways reveals vulnerable nodes such as HIF1αsignaling,α-KG-dependent demethylation,and lactate-driven epigenetic remodeling that may be exploited for targeted treatment of metastatic brain tumors.The present review aims to provide in-depth insights into epigenetic regulation,including chromatin and histone modifications as well as noncoding RNAs and metabolic reprogramming,highlighting how the two interplay in the development and progression of metastatic brain tumors and their therapeutic potential.展开更多
Dongyuemiao Member shale in the Sichuan Basin,China,is characterized by organic-rich shale intervals with different types of interbeds and accumulation modes.The aim of this study is to elucidate the impact of paleoen...Dongyuemiao Member shale in the Sichuan Basin,China,is characterized by organic-rich shale intervals with different types of interbeds and accumulation modes.The aim of this study is to elucidate the impact of paleoenvironmental indicators on interbed development.With this aim in mind,we established an interbed classification scheme and quantified the development of different types of interbeds and their frequencies.We categorized the shale interbeds into three types based on interbed type:silt interbeds(SIs),shell fragment interbeds(SFIs),and shell skeleton interbeds(SSIs).The SIs,SFIs,and SSIs are respectively the products of extrabasinal low-density turbidity currents,intrabasinal debris flow,and intrabasinal low-density turbidity currents.We propose that variations in paleoenvironmental conditions primarily influenced the types of interbeds that developed but had minimal impact on the frequency of their development.Models depicting the interbed development within the 1st Submember of Dongyuemiao Member indicate that during the early Dongyuemiao depositional period,under conditions of relatively aridity,weak weathering,high terrigenous input,and strong hydrodynamic activity,SSIs were well developed.In the middle depositional period,as the climate gradually transitioned to more humid conditions,and the weathering intensity and amount of terrestrial input increased,the development of SIs and SFIs significantly increased.During the late depositional period,with a continuous decrease in terrestrial inputs and sedimentation rates,the development of SIs decreased while that of SSIs increased.展开更多
The adult subventricular zone of the lateral ventricles and the subgranular zone in the hippocampal dentate gyrus(DG)are the two brain regions where neurogenesis occurs throughout life in the adult mammalian brain(Min...The adult subventricular zone of the lateral ventricles and the subgranular zone in the hippocampal dentate gyrus(DG)are the two brain regions where neurogenesis occurs throughout life in the adult mammalian brain(Ming and Song,2011).Adult quiescent hippocampal neural stem cells(NSCs)are bona fide stem cells and,when activated,give rise to newborn granule neurons in the adult brain,which play vital roles in learning,memory,mood,and affective cognition(Bonaguidi et al.,2011;Ming and Song,2011).展开更多
Large regional differences and uneven regional development are fundamental challenges for China. Balanced regional development is an important issue in research on development geography. This study reviews the course ...Large regional differences and uneven regional development are fundamental challenges for China. Balanced regional development is an important issue in research on development geography. This study reviews the course of balanced regional development in China and summarizes its characteristics in each period. The results show that inter-regional development in China has undergone successive periods of balanced and unbalanced development. Each period has enhanced social development and contributed to a more balanced regional development. This paper discusses the scientific connotation of balanced regional development, and invokes sustainable development theory to argue that we should pay attention to the differences in resource endowments among regions, and solves the imbalance among the economy, humans, and nature to promote the spatial balance of regional development and green development for better coordination between economy and ecology. The balanced promotion of the well-being of people in each region is the ultimate goal of balanced regional development. We then use concepts from development geography to examine China’s path of balanced regional development from the three perspectives of society, the economy, and ecology. Suggestions are also provided for the balanced development of China’s regions and the improvement of public well-being.展开更多
基金supported by grants from Simons Foundation (SFARI 479754),CIHR (PJT-180565)the Scottish Rite Charitable Foundation of Canada (to YL)funding from the Canada Research Chairs program。
文摘The mechanistic target of rapamycin(m TOR) is a serine/threonine kinase that plays a pivotal role in cellular growth, proliferation, survival, and metabolism. In the central nervous system(CNS), the mTOR pathway regulates diverse aspects of neural development and function. Genetic mutations within the m TOR pathway lead to severe neurodevelopmental disorders, collectively known as “mTORopathies”(Crino, 2020). Dysfunctions of m TOR, including both its hyperactivation and hypoactivation, have also been implicated in a wide spectrum of other neurodevelopmental and neurodegenerative conditions, highlighting its importance in CNS health.
文摘China aims to build on its achievements of the past five years to accelerate rural revitalization during the 15th Five-Year Plan period.IN China,issues relating to agriculture,rural areas,and rural residents have always been a priority in national development.At its fourth plenary session held in October 2025,the 20th Central Committee of the Communist Party of China(CPC)once again emphasized the need to accelerate agricultural and rural modernization,and advance all-around rural revitalization over the next five years.
文摘Each spring,China’s largest political gathering,the Two Sessions,brings together the National People’s Congress and the National Committee of the Chinese People’s Political Consultative Conference to set the nation’s broad policy direction for the year.
文摘The year 2026 marks the 70th anniversary of the establishment of diplomatic relations between China and African countries.It also marks the launch of the China-Africa Year of People-to-People Exchanges.At this pivotal juncture linking past achievements with future development,Wang Yi,member of the Political Bureau of the Communist Party of China Central Committee and foreign minister,continued the longstanding diplomatic tradition under which the Chinese foreign minister makes Africa the destination of the first overseas visit of the year,a practice upheld for 36 consecutive years,underscoring the stability,continuity and sincerity of China’s policy towards Africa.
文摘The shale gas development in China faces challenges such as complex reservoir conditions and high development costs.Based on the pore pressure and geostress coupling theory,this paper studies the geostress evolution laws and fracture network characteristics of shale gas infill wells.A mechanism model of CN platform logging data and geomechanical parameters is established to simulate the influence of parent well’s production on the geostress in the infill well area.It is suggested that with the increase of production time,normal fault stress state and horizontal stress deflection will occur.The smaller the parent well spacing and the longer the production time,the earlier the normal fault stress state appears and the larger the range.Based on the model,the fracture network morphology and construction parameters of infill wells are optimized.parentparentparentparent The results indicate that:1:A well spacing of 500 m achieves a Pareto optimum between“full reserve coverage”and“stress barrier”;2:A parent well recovery degree of 30%corresponds to the critical point of stress reversal,where the lateral deflection rate of the infill fracture is less than 8%and the SRV loss is minimized;3:6-cluster intensive completion with twice the liquid intensity increases the fracture complexity index by 1.7 times,enhances well group EUR by 15.4%,and reduces single-well cost by 22%.This research fills the theoretical gap in the collaborative optimization of“multi-parameter,multi-objective and multi-constraint”and provide parameter optimization basis for shale gas infill well development in China and help to improve the development efficiency and economic benefits.
基金supported by the following grants:National Social Science Fund of China(NSSFC)(Major Project)“Research on the Mechanism and Breakthrough Path for Achieving Key Core Technologies through the Coupling of Innovation Chains and Industrial Chains”(Grant No.22&ZD093)Key Research Institute of Humanities and Social Sciences,Ministry of Education“Research on Innovation Development Theory Based on Chinese Practice”(Grant No.23CEDRZ03).
文摘In the complex architecture of global value-chain(GVC)trade,firms’technological content increasingly reflects external knowledge flows.This study examines how inter-regional technological complementarity shapes firms’GVC advancement,measured by the domestic value-added rate(DVAR)in exports.Using integrated Chinese microdata(2000-2014),we find this complementarity significantly boosts export DVAR,explaining about one-quarter of its observed growth.Two mechanisms drive this effect:increased use of domestic intermediates and gains in firm productivity.The benefits are especially large for firms with lower human capital and for those in accessible,innovation-peripheral regions,helping narrow productivity gaps across firms and space.Affected firms also exhibit broader export scopes,higher product quality,more diversified destinations,and greater markups-firm-level evidence of GVC upgrading.These findings highlight how external technological linkages drive upgrading and underscore the importance of fostering inter-regional synergies for balanced development.
基金supported by the National Natural Science Foundation of China (42271252,42230510)。
文摘County-to-district conversion(CDC) has restructured the pattern of urban-rural development and influenced the allocation of resources by local governments as well as the urbanization process.However,the impact and mechanism of the CDC on China's urban-rural integration development(URID) are not yet clear.Using panel data from 52 county-level cities,districts,and counties in Jiangsu Province of China during 2005–2021,this paper constructed an evaluation system for URID and applied the multi-period difference-in-differences(DID) model to measure the impact of the CDC on URID and identify its primary mechanisms of action.The results demonstrated that the CDC has significantly fostered URID,though with pronounced regional heterogeneity.Specifically,while the CDC facilitated URID in the southern and central Jiangsu Province—regions characterized by high socio-economic development—it exerted a less significant impact in the comparatively underdeveloped northern Jiangsu Province.Mechanistically,the implementation of the CDC promotes equal regional development,enhances rural selfdevelopment capacity,improves environmental quality and living standards,and optimizes urban-rural land allocation and transport networks.Ultimately,this study clarifies the role of the CDC in China,provides insights for achieving URID,and offers a reference for other countries pursuing coordinated urban-rural development.
文摘For the first three decades of the 21st century,the United Nations(UN)guided global development through two successive agendas:the Millennium Development Goals(MDGs)and the Sustainable Development Goals(SDGs),each spanning 15 years.When the MDGs concluded in 2015,the 17 SDGs introduced a new vision for humanity,providing a framework for addressing global challenges and shaping international cooperation.Over the past decade.
基金Supported by the China National Science and Technology Major Project(2024ZD1405103)SINOPEC Science and Technology Major Project(P25184)。
文摘Centering on the critical bottlenecks in the development of shale oil in the Jiyang Depression of Shengli Oilfield,key scientific and engineering issues are proposed in aspects such as the storage space and occurrence state of shale oil,the formation mechanisms of multi-scale flow spaces,the mobilization mechanisms of crude oil in pores and fractures,and the enhanced oil recovery(EOR)mechanisms during the late stage of elastic development.The research progress and mechanistic insights in recent years are reviewed with respect to experimental techniques,characteristics of pore-fracture structure and fluid occurrence,fracture evolution mechanisms,shale oil flow mechanisms and EOR techniques.Through improving the experimental methods,optimizing the testing conditions,and developing new technologies,we deeply understand the occurrence state,storage space and flow pattern of shale oil,and reveal the distribution pattern of“oil-bearing in all pore sizes and oil-rich in large pores”and the differences in fluid phase states under the confinement effect of nano-scale pores in the shales of the Jiyang Depression;depict the characteristics of“restricted vertical expansion and complex fracture networks”of induced fractures and the dynamic evolution of fracture networks during the fracturing-soaking-production process;establish a“easy flow-slow flow-stagnant flow”three-zone model and the elastic drive+imbibition drive synergistic energy replenishment mechanism;and carry out high-pressure injection to further enhance the mass transfer and diffusion capacity of CO_(2)within the shale pore-fracture system,and compete for the desorption of alkanes to improve the mobilization degree of shale oil.The research achievements provide crucial support for the formation of the theory of continental shale oil development and the construction of the technical system.The future research efforts will focus on mine-scale multi-field coupling physical simulation equipment,microscopic to macroscopic multi-scale experimental methods,pore/fracture fine characterization and post-fracturing core fracture description technologies,multi-media fluid-structure coupling numerical simulation algorithms,and low-cost EOR and low-quality shale oil in-situ upgrading technologies,in order to promote the large-scale and profitable development of shale oil in the Jiyang Depression.
基金supported by the Agency for Defense Development Grant Funded by the Korean Government(Grant No.912822501).
文摘Unmanned combat aerial vehicles require lightweight,stealth-capable exhaust systems.However,traditional metallic nozzles increase radar detectability and reduce range,while advanced composites offer high performance but are expensive.Therefore,to improve the operational range and survivability of unmanned combat aerial vehicles,a lightweight,high-temperature-resistant,oxidation-resistant,and low-observable composite exhaust nozzle is developed to replace conventional metallic straight-type nozzles.The nozzle features a double serpentine shape to reduce radar and infrared signatures and is manufactured as a monolithic structure using the filament winding process,accommodating the complex geometry and large size(length:1.8 m,width:0.8 m).The exhaust nozzle consists of a ceramic matrix composite made of silicon carbide fibers and a silicon oxycarbide matrix,which absorbs and scatters radio frequency signals while withstanding prolonged exposure to high-temperature(700℃)oxidizing environments typical of engine exhaust gases.The polysiloxane resin used to produce the silicon oxycarbide matrix poses significant challenges owing to its low tackiness and high viscosity variations depending on the presence of nanoparticles,making filament winding difficult.These challenges are addressed by optimizing resin viscosity and winding pattern design.As a result,the tensile strength of the composite specimens fabricated with the optimized viscosity increases by 228.03% before pyrolysis and 97.68%after pyrolysis,compared with that of the non-optimized specimens.In addition,the density and tensile strength of the composite processed via three cycles of polymer infiltration and pyrolysis increased by 13.08% and 80.37%,respectively,compared to those of the non-densified composite.High-temperature oxidation and flame tests demonstrate exceptional thermal and oxidative stability.Furthermore,when compared with carbon fiber-reinforced ceramic matrix composites,the developed composite exhibits a permittivity at least two levels lower and a reflection loss below7 dB within the frequency range of 9.3-10.9 GHz,underscoring its superior electromagnetic stealth performance.
基金sponsored by the National Natural Science Foundation of China(Grant No.42202205)Natural Science Foundation of Shandong Province,China(Grant No.ZR2021QD072).-。
文摘The vertical heterogeneity of the pore structure in deep coal seams with varying ash yields is a key control for coalbed methane storage and producibility;however,its specific impact on gas adsorption is not clearly defined.The focus of this study is the No.8 coal seam of the Carboniferous Benxi Formation in the Central-Eastern Ordos Basin.By integrating microscopic identification,proximate analysis,gas adsorption(CO_(2),N_(2),and CH_(4)),and the multifractal theory,we quantitatively characterized the nanopore structure(micropores<2 nm and mesopores 2 nm-100 nm)of coal reservoirs with varying ash yields.The results indicate that(1)ash yield is the primary factor that controls the vertical evolution of pore structures in coal seams.In low-ash yield coal seams,the extent of thermal evolution and ash yield jointly constrain the heterogeneity of pore size distribution.In mediumto high-ash yield coal seams,the heterogeneity of pore structure and pore size distribution are predominantly constrained by ash yield.(2)As the ash yield vertically increases,the mesoporous pore volume and specific surface area initially decrease and subsequently increase,while the contribution of micropores to both pore volume and specific surface area continuously diminishes.Consequently,the total pore volume and specific surface area of the coal samples exhibit a two-stage reduction close to an ash yield threshold of approximately 20%.(3)Further,the Langmuir volume for CH_(4)adsorption sharply declines below the 20%threshold,followed by a gradual decrease;in contrast,the Langmuir pressure initially decreases and subsequently increases.Hence,the vertical increase in ash yield constrains the development of pore systems and diminishes pore connectivity,thereby reducing methane adsorption capacity and adversely affecting coalbed methane productivity.(4)Low-ash yield coal reservoirs are characterized by a rapid gas breakthrough and high productivity,whereas medium-ash yield coal reservoirs generally require prolonged depressurization to achieve peak gas production.These findings reveal that in medium-high rank coal,ash yield―and not thermal evolution―is the main factor that controls vertical pore evolution and methane adsorption efficiency.The quantitative ash yield threshold(20%)established in this study provides a practical criterion for evaluating reservoir quality and predicting vertical variations in gas storage potential in the Ordos Basin.
基金supported by grants from the Natural Science Foundation of Jiangsu Province(BK20221377 and BK20220607)the Natural Science Foundation of the Jiangsu Higher Education Institutions of China(22KJB180023)the National Natural Science Foundation of China Grants(32200783,32350017,and 92368104),and the Qing Lan Project of Jiangsu Province.
文摘Hearing and balance disorders are significant health issues primarily caused by developmental defects or the irreversible loss of sensory hair cells(HCs).ldentifying the underlying genes involved in the morphogenesis and development of HCs is crucial.Our current study highlights rhpn2,a member of rho-binding proteins,as essential for vestibular HC development.The rhpn2 gene is highly expressed in the crista and macula HCs.Loss of rhpn2 function in zebrafish reduces the otic vesicle area and vestibular HC number,accompanied by vestibular dysfunction.Shorter stereocilia and compromised mechanotransduction channel function are found in the crista HCs of rhpn2 mutants.Transcriptome RNA sequencing analysis predicts the potential interaction of rhpn2 with rhoab.Furthermore,co-immunoprecipitation confirms that Rhpn2 directly binds to RhoA,validating the interaction of the two proteins.rhpn2 knockout leads to a decreased expression of rock2b,a canonical RhoA signaling pathway gene.Treatment with the RhoA activator or exogenous rock2b mRNA injection mitigates crista HC stereocilia defects in rhpn2 mutants.This study uncovers the role of rhpn2 in vestibular HC development and stereocilia formation via mediating the RhoA signaling pathway,providing a target for the treatment of balance disorders.
基金supported by the National Key Research and Development Program of China (2021YFB1507401)Qinghai Province Clean Energy Minerals Special Project(2022013004qj004)Geological Survey Project of China Geological Survey (DD20221676, DD20230019)。
文摘The available heat content (stored heat energy) of hot dry rock (HDR) at a depth of 1–10 km in the global land crust is estimated to be 5.06×10~8 EJ,attracting considerable global attention.This paper presents a comprehensive analysis of the geological framework,HDR resource potential,exploration advancements,and the development of enhanced geothermal systems (EGSs) in China.HDR resources are extensively distributed across China.Within the depth range of 3–10 km,China’s estimated potential approximates2.29×10~7 EJ,with a theoretical power generation capacity of approximately 1.67×10^(16) k Wh.Replacing coal power with HDR can help to achieve a net emission reduction of 1.34×10^(16) kg CO_(2) (approximately1.34×10^(13) t),representing an emission reduction efficiency of 94.4%.Based on a development cycle of100 years,the average annual emission reduction reaches 1.34×10^(10) t CO_(2),equivalent to 117%of China’s annual carbon emissions in 2022.Furthermore,in the context of global warming,the development and utilization of HDR,which is feasible in virtually any region worldwide,offers significant potential to support global carbon reduction efforts.China has made substantial progress in HDR exploration in recent years.This paper systematically classifies China’s HDR resources into four genetic types—highly radioactive heat-producing,sedimentary basin,active volcanic,and intensely tectonic zones—and offers detailed exploration insights for each category.Each classification exhibits distinct geological and tectonic characteristics that influence heat source mechanisms and resource distribution.Furthermore,this paper documents significant advances in EGS construction,particularly in the Gonghe Basin on the northeastern margin of the Qianghai-Xizang Plateau and the Matouying uplift in the North China Basin,where successful reservoir stimulation,microseismic monitoring,and experimental power generation have been achieved.Despite these developments,challenges persist,including technical adaptability under complex geological conditions and the economic viability of large-scale HDR development.This paper suggests that future initiatives should emphasize resource exploration,technological research,and policy support to foster sustainable HDR resource development in China,thereby contributing to the global energy transition and environmental sustainability.
基金supported by the Shenzhen Science and Technology Innovation Commission,No.JCYJ20220818103009018(to YD).
文摘The arginine-phenylalanine-amide neuropeptide receptor family comprises a subclass within the G protein-coupled receptor superfamily with crucial roles in physiological regulation.These receptors recognize and bind neuropeptides with an arginine-phenylalanine-amide motif,thereby participating in a variety of biological processes such as energy metabolism,pain perception,and reproductive functions.In this review,we explore the physiological and pathological processes involving these receptors and delve into the structure-activity relationships of their ligand peptides,clarifying the key structural motifs within these neuropeptides that determine their biological activity,pharmacological potency,and receptor selectivity.Particular emphasis is placed on their roles in modulating nociception,regulating appetite,and maintaining reproductive health.Additionally,we discuss the therapeutic potential of structure-based drug design targeting these receptors based on existing cryo-electron microscopy structures.The available structural insights into ligand-binding pockets and G protein-receptor interaction interfaces provide a clear perspective and valuable complement to ligand optimization.
基金funded by the LPDP-RIIM,Research Grant No.18/IV/KS/06/2022 and 4830/IT3.L1/PT.01.03/P/B/2022,titled Pengembangan Produk Oriented Strand Board Unggul dari Kayu Ringan dan Cepat Tumbuh dalam Rangka Pengembangan Produk Biokomposit Prospektif.
文摘Recent advancements in developing tannin-based non-isocyanate polyurethane(NIPU)resins have unlocked new possibilities for sustainable and eco-friendly wood adhesives.Unlike conventional polyurethane,NIPUs eliminate hazardous isocyanates,offering safer alternatives for industrial applications.Tannin,a naturally occurring polyphenolic compound,plays a pivotal role in enhancing these resins’fire-resistance and super-hydrophobic properties.This review highlights key developments in synthesizing tannin-based NIPU,focusing on various polymerization techniques such as polyaddition,polycondensation,ring-opening polymerization,and rearrangement.These strategies contribute to improved mechanical strength,thermal stability,and resistance to water absorption.Recent studies demonstrate that tannin-based NIPU adhesives meet or exceed international internal bonding strength,elasticity,and durability standards.Their application in wood-based composites like oriented strand boards(OSB)has shown promising results,offering improved resistance to moisture and superior dimensional stability.Furthermore,the cross-linked polymer network,supported by chemical modifications like the introduction of fluoroalkyl groups,significantly enhances hydrophobicity and fire retardancy.Despite these advancements,challenges remain in terms of scalability,cost,and integration with existing manufacturing processes.Future research should focus on optimizing reaction conditions,improving raw material availability,and developing industrial-scale production methods.This review underscores the potential of tannin-based NIPU resins as a viable and sustainable alternative for various wood composite applications.
基金supported by the National Natural Science Foundation of China Commission,Youth Project(No.82203150,No.82302304)Anhui Health Commission Research Project(No.2024Aa30184)+7 种基金The Bengbu City Health and Medical Research Project(BBWK2024A103)Cultivation grant for clinical and basic integration research of Shanghai Tenth People’s Hospital(SYYYRH2025020)Doctoral Workstation Foundation of Guangdong Second Provincial General Hospital,China(Grant No.2022BSGZ011)Elevate Engineering Foundation of Guangdong Second Provincial General Hospital,China(Grant No.TJGC2022009)Science and Technology Program of Guangzhou,China(2024A04J4159)China Postdoctoral Science Foundation(2021M702137)Natural Science Foundation of Chongqing(cstc2021jcyj-msxmX1176)Chongming District Sustainable Development Science and Technology Innovation Initiative Project(CKY2022-30).
文摘Objectives:Bladder cancer(BCa)progression is closely linked to the immune microenvironment.However,the key molecules that regulate this microenvironment and their specific mechanisms remain poorly understood.This study aims to identify a key molecule and elucidate its mechanisms,providing a theoretical basis for identifying novel therapeutic targets.Methods:Immune microenvironment-related genes in BCa were identified using The Cancer Genome Atlas and Shanghai Tenth People’s Hospital datasets.Proteasome 26S subunit non-ATPase 2(PSMD2)expression was validated via quantitative polymerase chain reaction(qPCR),Western blot(WB)analysis,and immunofluorescence(IF).In vitro and in vivo experiments confirmed the role of PSMD2 in cell proliferation,invasion,and migration.Kyoto encyclopedia of genes and genomes(KEGG)and Gene Ontology(GO)analyses were conducted to assess PSMD2’s influence on immune microenvironment remodeling.A pathomics model predicted PSMD2 expression in patients with BCa.Results:PSMD2 was identified as a critical factor in BCa,with high expression correlating with poor prognosis and tumor progression.Mechanistically,PSMD2 enhances malignancy by promoting mitogen-activated protein kinase kinase(MEK)and extracellular signal-regulated kinase(ERK)phosphorylation within the mitogen-activated protein kinase(MAPK)signaling pathway.Combined bioinformatics and experimental analyses reveal that PSMD2 downregulates chemokine(C-X-C motif)ligand 14(CXCL14)expression and secretion via the MAPK pathway,thereby remodeling the immune microenvironment and driving tumor progression.Pathomics analysis further supports the potential of PSMD2 expression as a predictive marker in BCa tissues.Conclusion:PSMD2 is overexpressed in BCa and significantly correlates with poor prognosis and tumor progression.It promotes malignant development and immune microenvironment remodeling through the MAPK pathway.Pathological analysis can predict PSMD2 expression,offering valuable insights into immunotherapy responses and survival outcomes.
文摘Metastatic brain tumors undergo profound metabolic-epigenetic reprogramming driven by the unique constraints of the brain microenvironment.Hypoxia-inducible factor-1α(HIF1α)enhances glycolytic flux,lactate accumulation,and histone lactylation,collectively supporting metastatic colonization and immune evasion.Key metabolites including acetyl-CoA,S-adenosylmethionine(SAM),α-ketoglutarate(α-KG),fumarate,and 2-hydroxyglutarate(2-HG)-directly modify chromatin states by regulating histone acetyltransferases,DNA/histone methyltransferases,andα-KG dependent dioxygenases such as Ten-Eleven Translocation(TET)enzymes and lysine demethylases(KDMs).These metabolic shifts result in aberrant DNA methylation,histone lysine residue at position 27 on Histone H3(H3K27)trimethylation,and depletion of 5-hydroxymethylcytosine(5hmC),all of which are hallmark epigenetic alterations in brain metastasis and primary Central Nervous System(CNS)tumors.Additionally,the blood-brain barrier(BBB)and blood-tumor barrier(BTB)impose nutrient restrictions and induce metabolic dependency on glutamine,acetate,and lactate shuttling,thereby reshaping epigenetic enzyme activity.We synthesize current mechanistic evidence showing how metabolic pressures in the brain microenvironment remodel the epigenome to promote tumor plasticity,stemness,and therapeutic resistance.Understanding these coupled pathways reveals vulnerable nodes such as HIF1αsignaling,α-KG-dependent demethylation,and lactate-driven epigenetic remodeling that may be exploited for targeted treatment of metastatic brain tumors.The present review aims to provide in-depth insights into epigenetic regulation,including chromatin and histone modifications as well as noncoding RNAs and metabolic reprogramming,highlighting how the two interplay in the development and progression of metastatic brain tumors and their therapeutic potential.
基金sponsored by the National Natural Science Foundation of China,China(No.42272171)National Science and Technology Major Project of China,China(No.2017ZX05036).
文摘Dongyuemiao Member shale in the Sichuan Basin,China,is characterized by organic-rich shale intervals with different types of interbeds and accumulation modes.The aim of this study is to elucidate the impact of paleoenvironmental indicators on interbed development.With this aim in mind,we established an interbed classification scheme and quantified the development of different types of interbeds and their frequencies.We categorized the shale interbeds into three types based on interbed type:silt interbeds(SIs),shell fragment interbeds(SFIs),and shell skeleton interbeds(SSIs).The SIs,SFIs,and SSIs are respectively the products of extrabasinal low-density turbidity currents,intrabasinal debris flow,and intrabasinal low-density turbidity currents.We propose that variations in paleoenvironmental conditions primarily influenced the types of interbeds that developed but had minimal impact on the frequency of their development.Models depicting the interbed development within the 1st Submember of Dongyuemiao Member indicate that during the early Dongyuemiao depositional period,under conditions of relatively aridity,weak weathering,high terrigenous input,and strong hydrodynamic activity,SSIs were well developed.In the middle depositional period,as the climate gradually transitioned to more humid conditions,and the weathering intensity and amount of terrestrial input increased,the development of SIs and SFIs significantly increased.During the late depositional period,with a continuous decrease in terrestrial inputs and sedimentation rates,the development of SIs decreased while that of SSIs increased.
基金supported by National Institutes of Health(R35NS137480,R35NS116843,and RF1AG079557)by Dr.Miriam and Sheldon G.Adelson Medical Research Foundation.
文摘The adult subventricular zone of the lateral ventricles and the subgranular zone in the hippocampal dentate gyrus(DG)are the two brain regions where neurogenesis occurs throughout life in the adult mammalian brain(Ming and Song,2011).Adult quiescent hippocampal neural stem cells(NSCs)are bona fide stem cells and,when activated,give rise to newborn granule neurons in the adult brain,which play vital roles in learning,memory,mood,and affective cognition(Bonaguidi et al.,2011;Ming and Song,2011).
基金National Natural Science Foundation of China,No.41771568Social Development Science and Technology Project of Chaoyang District,Beijing,China,No.CYSF1906。
文摘Large regional differences and uneven regional development are fundamental challenges for China. Balanced regional development is an important issue in research on development geography. This study reviews the course of balanced regional development in China and summarizes its characteristics in each period. The results show that inter-regional development in China has undergone successive periods of balanced and unbalanced development. Each period has enhanced social development and contributed to a more balanced regional development. This paper discusses the scientific connotation of balanced regional development, and invokes sustainable development theory to argue that we should pay attention to the differences in resource endowments among regions, and solves the imbalance among the economy, humans, and nature to promote the spatial balance of regional development and green development for better coordination between economy and ecology. The balanced promotion of the well-being of people in each region is the ultimate goal of balanced regional development. We then use concepts from development geography to examine China’s path of balanced regional development from the three perspectives of society, the economy, and ecology. Suggestions are also provided for the balanced development of China’s regions and the improvement of public well-being.
