The mechanistic target of rapamycin(m TOR) is a serine/threonine kinase that plays a pivotal role in cellular growth, proliferation, survival, and metabolism. In the central nervous system(CNS), the mTOR pathway regul...The mechanistic target of rapamycin(m TOR) is a serine/threonine kinase that plays a pivotal role in cellular growth, proliferation, survival, and metabolism. In the central nervous system(CNS), the mTOR pathway regulates diverse aspects of neural development and function. Genetic mutations within the m TOR pathway lead to severe neurodevelopmental disorders, collectively known as “mTORopathies”(Crino, 2020). Dysfunctions of m TOR, including both its hyperactivation and hypoactivation, have also been implicated in a wide spectrum of other neurodevelopmental and neurodegenerative conditions, highlighting its importance in CNS health.展开更多
China aims to build on its achievements of the past five years to accelerate rural revitalization during the 15th Five-Year Plan period.IN China,issues relating to agriculture,rural areas,and rural residents have alwa...China aims to build on its achievements of the past five years to accelerate rural revitalization during the 15th Five-Year Plan period.IN China,issues relating to agriculture,rural areas,and rural residents have always been a priority in national development.At its fourth plenary session held in October 2025,the 20th Central Committee of the Communist Party of China(CPC)once again emphasized the need to accelerate agricultural and rural modernization,and advance all-around rural revitalization over the next five years.展开更多
The year 2026 marks the 70th anniversary of the establishment of diplomatic relations between China and African countries.It also marks the launch of the China-Africa Year of People-to-People Exchanges.At this pivotal...The year 2026 marks the 70th anniversary of the establishment of diplomatic relations between China and African countries.It also marks the launch of the China-Africa Year of People-to-People Exchanges.At this pivotal juncture linking past achievements with future development,Wang Yi,member of the Political Bureau of the Communist Party of China Central Committee and foreign minister,continued the longstanding diplomatic tradition under which the Chinese foreign minister makes Africa the destination of the first overseas visit of the year,a practice upheld for 36 consecutive years,underscoring the stability,continuity and sincerity of China’s policy towards Africa.展开更多
In the complex architecture of global value-chain(GVC)trade,firms’technological content increasingly reflects external knowledge flows.This study examines how inter-regional technological complementarity shapes firms...In the complex architecture of global value-chain(GVC)trade,firms’technological content increasingly reflects external knowledge flows.This study examines how inter-regional technological complementarity shapes firms’GVC advancement,measured by the domestic value-added rate(DVAR)in exports.Using integrated Chinese microdata(2000-2014),we find this complementarity significantly boosts export DVAR,explaining about one-quarter of its observed growth.Two mechanisms drive this effect:increased use of domestic intermediates and gains in firm productivity.The benefits are especially large for firms with lower human capital and for those in accessible,innovation-peripheral regions,helping narrow productivity gaps across firms and space.Affected firms also exhibit broader export scopes,higher product quality,more diversified destinations,and greater markups-firm-level evidence of GVC upgrading.These findings highlight how external technological linkages drive upgrading and underscore the importance of fostering inter-regional synergies for balanced development.展开更多
The vertical heterogeneity of the pore structure in deep coal seams with varying ash yields is a key control for coalbed methane storage and producibility;however,its specific impact on gas adsorption is not clearly d...The vertical heterogeneity of the pore structure in deep coal seams with varying ash yields is a key control for coalbed methane storage and producibility;however,its specific impact on gas adsorption is not clearly defined.The focus of this study is the No.8 coal seam of the Carboniferous Benxi Formation in the Central-Eastern Ordos Basin.By integrating microscopic identification,proximate analysis,gas adsorption(CO_(2),N_(2),and CH_(4)),and the multifractal theory,we quantitatively characterized the nanopore structure(micropores<2 nm and mesopores 2 nm-100 nm)of coal reservoirs with varying ash yields.The results indicate that(1)ash yield is the primary factor that controls the vertical evolution of pore structures in coal seams.In low-ash yield coal seams,the extent of thermal evolution and ash yield jointly constrain the heterogeneity of pore size distribution.In mediumto high-ash yield coal seams,the heterogeneity of pore structure and pore size distribution are predominantly constrained by ash yield.(2)As the ash yield vertically increases,the mesoporous pore volume and specific surface area initially decrease and subsequently increase,while the contribution of micropores to both pore volume and specific surface area continuously diminishes.Consequently,the total pore volume and specific surface area of the coal samples exhibit a two-stage reduction close to an ash yield threshold of approximately 20%.(3)Further,the Langmuir volume for CH_(4)adsorption sharply declines below the 20%threshold,followed by a gradual decrease;in contrast,the Langmuir pressure initially decreases and subsequently increases.Hence,the vertical increase in ash yield constrains the development of pore systems and diminishes pore connectivity,thereby reducing methane adsorption capacity and adversely affecting coalbed methane productivity.(4)Low-ash yield coal reservoirs are characterized by a rapid gas breakthrough and high productivity,whereas medium-ash yield coal reservoirs generally require prolonged depressurization to achieve peak gas production.These findings reveal that in medium-high rank coal,ash yield―and not thermal evolution―is the main factor that controls vertical pore evolution and methane adsorption efficiency.The quantitative ash yield threshold(20%)established in this study provides a practical criterion for evaluating reservoir quality and predicting vertical variations in gas storage potential in the Ordos Basin.展开更多
The available heat content (stored heat energy) of hot dry rock (HDR) at a depth of 1–10 km in the global land crust is estimated to be 5.06×10~8 EJ,attracting considerable global attention.This paper presents a...The available heat content (stored heat energy) of hot dry rock (HDR) at a depth of 1–10 km in the global land crust is estimated to be 5.06×10~8 EJ,attracting considerable global attention.This paper presents a comprehensive analysis of the geological framework,HDR resource potential,exploration advancements,and the development of enhanced geothermal systems (EGSs) in China.HDR resources are extensively distributed across China.Within the depth range of 3–10 km,China’s estimated potential approximates2.29×10~7 EJ,with a theoretical power generation capacity of approximately 1.67×10^(16) k Wh.Replacing coal power with HDR can help to achieve a net emission reduction of 1.34×10^(16) kg CO_(2) (approximately1.34×10^(13) t),representing an emission reduction efficiency of 94.4%.Based on a development cycle of100 years,the average annual emission reduction reaches 1.34×10^(10) t CO_(2),equivalent to 117%of China’s annual carbon emissions in 2022.Furthermore,in the context of global warming,the development and utilization of HDR,which is feasible in virtually any region worldwide,offers significant potential to support global carbon reduction efforts.China has made substantial progress in HDR exploration in recent years.This paper systematically classifies China’s HDR resources into four genetic types—highly radioactive heat-producing,sedimentary basin,active volcanic,and intensely tectonic zones—and offers detailed exploration insights for each category.Each classification exhibits distinct geological and tectonic characteristics that influence heat source mechanisms and resource distribution.Furthermore,this paper documents significant advances in EGS construction,particularly in the Gonghe Basin on the northeastern margin of the Qianghai-Xizang Plateau and the Matouying uplift in the North China Basin,where successful reservoir stimulation,microseismic monitoring,and experimental power generation have been achieved.Despite these developments,challenges persist,including technical adaptability under complex geological conditions and the economic viability of large-scale HDR development.This paper suggests that future initiatives should emphasize resource exploration,technological research,and policy support to foster sustainable HDR resource development in China,thereby contributing to the global energy transition and environmental sustainability.展开更多
Dongyuemiao Member shale in the Sichuan Basin,China,is characterized by organic-rich shale intervals with different types of interbeds and accumulation modes.The aim of this study is to elucidate the impact of paleoen...Dongyuemiao Member shale in the Sichuan Basin,China,is characterized by organic-rich shale intervals with different types of interbeds and accumulation modes.The aim of this study is to elucidate the impact of paleoenvironmental indicators on interbed development.With this aim in mind,we established an interbed classification scheme and quantified the development of different types of interbeds and their frequencies.We categorized the shale interbeds into three types based on interbed type:silt interbeds(SIs),shell fragment interbeds(SFIs),and shell skeleton interbeds(SSIs).The SIs,SFIs,and SSIs are respectively the products of extrabasinal low-density turbidity currents,intrabasinal debris flow,and intrabasinal low-density turbidity currents.We propose that variations in paleoenvironmental conditions primarily influenced the types of interbeds that developed but had minimal impact on the frequency of their development.Models depicting the interbed development within the 1st Submember of Dongyuemiao Member indicate that during the early Dongyuemiao depositional period,under conditions of relatively aridity,weak weathering,high terrigenous input,and strong hydrodynamic activity,SSIs were well developed.In the middle depositional period,as the climate gradually transitioned to more humid conditions,and the weathering intensity and amount of terrestrial input increased,the development of SIs and SFIs significantly increased.During the late depositional period,with a continuous decrease in terrestrial inputs and sedimentation rates,the development of SIs decreased while that of SSIs increased.展开更多
The adult subventricular zone of the lateral ventricles and the subgranular zone in the hippocampal dentate gyrus(DG)are the two brain regions where neurogenesis occurs throughout life in the adult mammalian brain(Min...The adult subventricular zone of the lateral ventricles and the subgranular zone in the hippocampal dentate gyrus(DG)are the two brain regions where neurogenesis occurs throughout life in the adult mammalian brain(Ming and Song,2011).Adult quiescent hippocampal neural stem cells(NSCs)are bona fide stem cells and,when activated,give rise to newborn granule neurons in the adult brain,which play vital roles in learning,memory,mood,and affective cognition(Bonaguidi et al.,2011;Ming and Song,2011).展开更多
Large regional differences and uneven regional development are fundamental challenges for China. Balanced regional development is an important issue in research on development geography. This study reviews the course ...Large regional differences and uneven regional development are fundamental challenges for China. Balanced regional development is an important issue in research on development geography. This study reviews the course of balanced regional development in China and summarizes its characteristics in each period. The results show that inter-regional development in China has undergone successive periods of balanced and unbalanced development. Each period has enhanced social development and contributed to a more balanced regional development. This paper discusses the scientific connotation of balanced regional development, and invokes sustainable development theory to argue that we should pay attention to the differences in resource endowments among regions, and solves the imbalance among the economy, humans, and nature to promote the spatial balance of regional development and green development for better coordination between economy and ecology. The balanced promotion of the well-being of people in each region is the ultimate goal of balanced regional development. We then use concepts from development geography to examine China’s path of balanced regional development from the three perspectives of society, the economy, and ecology. Suggestions are also provided for the balanced development of China’s regions and the improvement of public well-being.展开更多
The study offers a conceptual framework illuminating sustainable rural development by a continuous cycling interplay among five interdependent systems,physical,social,economic,knowledge,and creative.The framework is a...The study offers a conceptual framework illuminating sustainable rural development by a continuous cycling interplay among five interdependent systems,physical,social,economic,knowledge,and creative.The framework is applied to analyze the livelihood transition in the economic system and conversion of traditional knowledge in the creative system for farm households engaged in large cardamom cultivation in Northern mountainous region in Vietnam.This study used a probit model to examine a data set comprising 300 households and confirmed that factors within the social and physical systems(such as labor,access to information,social networks,land use,and transportation infrastructure)determined livelihood transition to tourism employment within the economic system.In addition,the conversion of traditional knowledge in the creative system was found to be contingent upon non-farm employment and credit capital in the economic system,as well as traditional knowledge and knowledge exchange in the knowledge system.This study demonstrates how the sustainable development of rural agriculture can be achieved by converting traditional knowledge and transferring livelihood,contributing to attain Sustainable Development Goals 2(Zero Hunger)and SDG 12(Responsible Consumption and Production).展开更多
China has achieved the poverty reduction goal of the United Nations 2030 Agenda for Sustainable Development 10 years ahead of schedule,contributing significantly to global poverty reduction.Despite extended efforts in...China has achieved the poverty reduction goal of the United Nations 2030 Agenda for Sustainable Development 10 years ahead of schedule,contributing significantly to global poverty reduction.Despite extended efforts in poverty elimination,there is a lack of quantitative studies categorizing and comparing poverty-elimination counties(PECs)based on their processes.This study proposes an innovative framework for analyzing PECs’development paths from the perspective of population-land-industry(PLI).We quantify the PLI matching degree of PECs in China during the critical phase of the battle against poverty through a multivariate matching model,classify PECs via K-means clustering according to the consistency in PLI matching degree evolution,and summarize the typical development patterns of PECs.Results indicate that the PLI matching degree of PECs in China increased substantially from 2015 to 2020,particularly in eastern areas,while the western region,including the Qinghai-Xizang Plateau and southwestern Xinjiang,shows untapped potential for improvement.Five types of PECs are identified,with the majority(30.1%)showing sustained moderate PLI matching and a minority(9.6%)experiencing long-term PLI mismatch.Industry is the shortfall of various PECs,and effective strategies to facilitate all types of PECs include the development of emerging businesses and the expansion of secondary and tertiary industries.Additionally,enriching rural labor force and increasing farmland use efficiency are essential for optimal PLI matching and positive interaction,ultimately ensuring poverty elimination and sustainable development.展开更多
Background There have been numerous intervention studies focusing on the development of preterm infants,but there has been limited investigation into the home environment as a determinant of developmental outcomes in ...Background There have been numerous intervention studies focusing on the development of preterm infants,but there has been limited investigation into the home environment as a determinant of developmental outcomes in preterm infants.The aspects and extent to which the home environment affects the early(18 months corrected age)neuropsychological development of preterm infants are still unclear.Aims This study aimed to analyse the effect of the home environment on the neuropsychiatric development of preterm infants at 18 months corrected age after discharge from the neonatal intensive care unit(NICU).It also sought to provide a basis for promoting neuropsychiatric development among preterm infants by improving the home environment.Methods In this retrospective cross-sectional study,275 preterm infants born between January 2019 and January 2022 were followed up for systematic management after discharge from the NICU at Shanghai Children's Hospital.The Home Nurture Environment Questionnaire was used to assess the home environment of the infants and analyse its impact on the developmental quotient(evaluated by the Gesell Developmental Scale)and the rate of developmental delays at 18 months corrected age.Results A total of 41.454%of the infants were extremely preterm.The developmental quotient scores at 18 months corrected age were in the middle of the scale.The language domain had the highest rate of developmental delay(46.182%),followed by the adaptive domain(37.091%).Multiple logistic regression analyses showed that compared with infants in supportive home environments,infants with moderate/unsupportive home environments had significantly elevated risks of development delay:2.162-fold for global(odds ratio(OR)2.162,95% confidence interval(Cl)1.274 to 3.665,p=0.004),2.193-fold for fine motor(OR 2.193,95%CI 1.161 to 4.140,p=0.016),2.249-fold for language(0R 2.249,95%CI 1.336 to 3.786,p=0.002)and 2.042-fold for personal-social(OR 2.042,95%CI 1.149 to 3.628,p=0.015).Conclusions A supportive home environment is a crucial protective factor for the neuropsychological development of preterm infants.It is associated with higher developmental quotient scores and protects against neuropsychiatric delays.Incorporating evaluation and continuous improvement of the home environment into the management framework for preterm infants to promote optimal neurodevelopment is essential.展开更多
Pentatricopeptide repeat(PPR)proteins are a large group of eukaryote-specific RNA-binding proteins that play pivotal roles in plant organelle gene expression.Here,we report the function of PPR21 in mitochondrial intro...Pentatricopeptide repeat(PPR)proteins are a large group of eukaryote-specific RNA-binding proteins that play pivotal roles in plant organelle gene expression.Here,we report the function of PPR21 in mitochondrial intron splicing and its role in maize kernel development.PPR21 is a typical P-type PPR protein targeted to mitochondria.The ppr21 mutants are arrested in embryogenesis and endosperm development,leading to embryo lethality.Null mutations of PPR21 reduce the splicing efficiency of nad2 intron 1,2,and 4 and impair the assembly and activity of mitochondrial complex I.Previous studies show that the P-type PPR protein EMP12 is required for the splicing of identical introns.However,our protein interaction analyses reveal that PPR21 does not interact with EMP12.Instead,both PPR21 and EMP12 interact with the small MutS-related(SMR)domain-containing PPR protein 1(PPR-SMR1)and the short P-type PPR protein 2(SPR2).PPR-SMR1 interacts with SPR2,and both proteins are required for the splicing of many introns in mitochondria,including nad2 intron 1,2,and 4.These results suggest that a PPR21-(PPR-SMR1/SPR2)-EMP12 complex is involved in the splicing of nad2 introns in maize mitochondria.展开更多
Purpose–This study summarizes the overall situation of the resources of the national science and technology innovation platform in the railway industry,including the distribution of platform types,supporting institut...Purpose–This study summarizes the overall situation of the resources of the national science and technology innovation platform in the railway industry,including the distribution of platform types,supporting institutions,construction sites,professional fields,etc.,to provide a reference for the further improvement and optimization of the national science and technology innovation platform system in the railway industry.Design/methodology/approach–Through literature review,field investigation,expert consultation and other methods,this paper systematically investigates and analyzes the development status of the national science and technology innovation platform in the railway industry.Findings–Taking the national science and technology innovation platform of the railway industry as the research object,this paper investigates and analyzes the construction,development and distribution of the national science and technology innovation platform of railway industry over the years.And the National Engineering Research Center of High-speed Railway and Urban Rail Transit System Technology was taken as an example to introduce its operation effect.Originality/value–China Railway has made great development achievements,with the construction and development of national science and technology innovation platform in the railway industry.In recent years,a large number of national science and technology innovation platforms have been built in the railway industry,which play an important role in railway technological innovation,standard setting and commodification,and Railway Sciences provide strong support for railway technology development.展开更多
Artificial intelligence(AI)is revolutionizing traditional drug discovery and development models by seamlessly integrating data,computational power,and algorithms.This synergy enhances the efficiency,accuracy,and succe...Artificial intelligence(AI)is revolutionizing traditional drug discovery and development models by seamlessly integrating data,computational power,and algorithms.This synergy enhances the efficiency,accuracy,and success rates of drug research,shortens development timelines,and reduces costs.Coupled with machine learning(ML)and deep learning(DL),AI has demonstrated significant advancements across various domains,including drug characterization,target discovery and validation,small molecule drug design,and the acceleration of clinical trials.Through molecular generation techniques,AI facilitates the creation of novel drug molecules,predicting their properties and activities,while virtual screening(VS)optimizes drug candidates.Additionally,AI enhances clinical trial efficiency by predicting outcomes,designing trials,and enabling drug repositioning.However,AI's application in drug development faces challenges,including the need for robust data-sharing mechanisms and the establishment of more comprehensive intellectual property protections for algorithms.AI-driven pharmaceutical companies must also integrate biological sciences and algorithms effectively,ensuring the successful fusion of wet and dry laboratory experiments.Despite these challenges,the potential of AI in drug development remains undeniable.As AI technology evolves and these barriers are addressed,AI-driven therapeutics are poised for a broader and more impactful future in the pharmaceutical industry.展开更多
The reform stems from honesty and determination. Since 2005, organ donation and transplantation in China has undergone thorough reform, which complies with legislation requirements and ethical principles established b...The reform stems from honesty and determination. Since 2005, organ donation and transplantation in China has undergone thorough reform, which complies with legislation requirements and ethical principles established by the World Health Organization(WHO). Reform in China has demonstrated the unwavering confidence and utmost determination of the Chinese government and the Chinese transplantation community. The year 2015 marked a historic turning point when voluntary donations from Chinese citizens became the sole legitimate source for organ transplantation. Since 2015, China has gradually established and refined the “Chinese Mode” and “China System” for organ donation and transplantation, fulfilling its political pledge of reform, and has garnered international recognition, and fostered a social culture which promotes organ donation. This article reviewed the history of reform on organ donation and transplantation in China, presented a new pattern of establishment of organ donation system in the new era of the country, and the direction of advances in the future.展开更多
This study endeavors to investigate the effects of Bifidobacterium breve CCFM1078 on bone formation and resorption balance in growing BALB/c mice.Newborn BALB/c mice were assigned to the control group(administration s...This study endeavors to investigate the effects of Bifidobacterium breve CCFM1078 on bone formation and resorption balance in growing BALB/c mice.Newborn BALB/c mice were assigned to the control group(administration saline)and the CCFM1078 group(administration B.breve CCFM1078,3×10^(9) CFU/day)in 3-,4-,and 5-week tests.All the groups have male and female distinctions.Our findings demonstrate that B.breve CCFM1078 exerts on the dynamic equilibrium between bone formation and resorption during the critical period of growth in mice by modulating the composition of gut microbiota and metabolites(hexadecanamide,linoleoyl ethanolamide,and palmitoyl ethanolamide),the genes and proteins expression related to the growth hormone(GH)/insulin-like growth factors-1(IGF-1)axis and Gs/PKA/CREB signaling pathways,as well as downstream osteogenic and osteoclastic differentiation factors.The effects of B.breve CCFM1078 were different with age and gender dependent.This finding suggests B.breve CCFM1078 may have potential applications in regulating bone metabolism in the growth period population.展开更多
This article focuses on the economic dividends of Heilongjiang Province hosting the 9th Asian Winter Games(2025),centered on the ice and snow economy’s high-quality development.Leveraging unique ice and snow resource...This article focuses on the economic dividends of Heilongjiang Province hosting the 9th Asian Winter Games(2025),centered on the ice and snow economy’s high-quality development.Leveraging unique ice and snow resources,Heilongjiang built a“sports events+full industrial chain”model,driving ice and snow tourism upgrading,equipment technology breakthroughs,and cultural brand internationalization.The event optimized the industrial structure by upgrading traditional industries,fostering emerging sectors,and advancing modern services.It also spurred infrastructure leapfrogs(transportation,smart cities,ecology),improved livelihoods(employment,income,public services),and boosted innovation(technology R&D,digital integration,opening-up).Looking ahead,Heilongjiang will use the event’s long-term effects to build a ice and snow-led modern industrial system for high-quality development.展开更多
Multiple sets of marine shale sequences occur in western Hubei Province and its adjacent areas within the Middle-Upper Yangtze region,offering substantial resource potential.However,their shale gas preservation condit...Multiple sets of marine shale sequences occur in western Hubei Province and its adjacent areas within the Middle-Upper Yangtze region,offering substantial resource potential.However,their shale gas preservation conditions differ significantly due to the heterogeneous porosity and fracture system resulting from multistage tectonic reworking.This necessitates developing region-specific evaluation systems and exploitation techniques.Drawing on previous application cases and guided by the research paradigm of geology-engineering integration,this study presents key technologies potentially applicable to shales in western Hubei Province,spanning from reservoir and sweet spot evaluation to fractu ring scheme design and fracturing perfo rmance monitoring.Several insights are gained accordingly.In terms of pore evaluation,the pore heterogeneity caused by compaction and rebound can be quantified using ideal shape coefficients and fractal dimensions,both of which are influenced by structural deformations,thereby guiding reservoir classification.For seismic data interpretation,pre-stack elastic inversion and azimuthal anisotropy inversion can be employed as core techniques,overcoming the limitation of individual post-stack attributes in typically detecting only major faults.Furthermore,the inversion boundaries are constrained using log-seismic joint quality control and geomechanical simulation,contributing to enhanced reliability of sweet spot evaluation and efficient exploration in areas with complex structures.For fracturing scheme design,scientifically formulated well shut-in strategies,tailored to regional geological characteristics,are essential to activate the fracture-matrix imbibition effect.Parameters with vastly different scales used in the design,such as meter-scale fracture halflength and millidarcy-scale fracture conductivity,can be co-optimized using artificial intelligence(AI)algorithms such as the genetic algorithm(GA)and the simultaneous perturbation stochastic approximation(SPSA)algorithm.Dynamic monitoring of fracturing performance can be achieved using trace chemical tracer technology,thereby reducing target ambiguity caused by structural complexity.Research on shale gas in the structurally complex areas of western Hubei faces multiple challenges,spanning from basic geological understanding to development engineering.These challenges create an urgent need for deep interdisciplinary collaboration.Therefore,this study highlights research into geology-engineering integration,aiming to enhance the efficiency of shale gas exploration and development in western Hubei.展开更多
Currently,unconventional reservoirs are characterized by low single well-controlled reserves,high initial production but fast production decline.This paper sorts out the problems of energy dispersion and limited lengt...Currently,unconventional reservoirs are characterized by low single well-controlled reserves,high initial production but fast production decline.This paper sorts out the problems of energy dispersion and limited length and height of main hydraulic fractures induced in staged multi-cluster fracturing,and proposes an innovative concept of“energy-focused fracturing development”.The technical connotation,theoretical model,and core techniques of energy-focused fracturing development are systematically examined,and the implementation path of this technology is determined.The energy-focused fracturing development technology incorporates the techniques such as geology-engineering integrated design,perforation optimization design,fracturing process design,and drainage engineering control.It transforms the numerous,short and dense hydraulic fractures to limited,long and sparse fractures.It focuses on fracturing energy,and aims to improve the fracture length,height and lateral width,and the proppant long-distance transportation capacity,thus enhancing the single well-controlled reserves and development effect.The energy-focused fracturing development technology has been successfully applied in the carbonate reservoirs in buried hill,shallow coalbed methane reservoirs,and coal-rock gas reservoirs in China,demonstrating the technology's promising application.It is concluded that the energy-focused fracturing development technology can significantly increase the single well production and estimated ultimate recovery(EUR),and will be helpful for efficiently developing low-permeability,unconventional and low-grade resources in China.展开更多
基金supported by grants from Simons Foundation (SFARI 479754),CIHR (PJT-180565)the Scottish Rite Charitable Foundation of Canada (to YL)funding from the Canada Research Chairs program。
文摘The mechanistic target of rapamycin(m TOR) is a serine/threonine kinase that plays a pivotal role in cellular growth, proliferation, survival, and metabolism. In the central nervous system(CNS), the mTOR pathway regulates diverse aspects of neural development and function. Genetic mutations within the m TOR pathway lead to severe neurodevelopmental disorders, collectively known as “mTORopathies”(Crino, 2020). Dysfunctions of m TOR, including both its hyperactivation and hypoactivation, have also been implicated in a wide spectrum of other neurodevelopmental and neurodegenerative conditions, highlighting its importance in CNS health.
文摘China aims to build on its achievements of the past five years to accelerate rural revitalization during the 15th Five-Year Plan period.IN China,issues relating to agriculture,rural areas,and rural residents have always been a priority in national development.At its fourth plenary session held in October 2025,the 20th Central Committee of the Communist Party of China(CPC)once again emphasized the need to accelerate agricultural and rural modernization,and advance all-around rural revitalization over the next five years.
文摘The year 2026 marks the 70th anniversary of the establishment of diplomatic relations between China and African countries.It also marks the launch of the China-Africa Year of People-to-People Exchanges.At this pivotal juncture linking past achievements with future development,Wang Yi,member of the Political Bureau of the Communist Party of China Central Committee and foreign minister,continued the longstanding diplomatic tradition under which the Chinese foreign minister makes Africa the destination of the first overseas visit of the year,a practice upheld for 36 consecutive years,underscoring the stability,continuity and sincerity of China’s policy towards Africa.
基金supported by the following grants:National Social Science Fund of China(NSSFC)(Major Project)“Research on the Mechanism and Breakthrough Path for Achieving Key Core Technologies through the Coupling of Innovation Chains and Industrial Chains”(Grant No.22&ZD093)Key Research Institute of Humanities and Social Sciences,Ministry of Education“Research on Innovation Development Theory Based on Chinese Practice”(Grant No.23CEDRZ03).
文摘In the complex architecture of global value-chain(GVC)trade,firms’technological content increasingly reflects external knowledge flows.This study examines how inter-regional technological complementarity shapes firms’GVC advancement,measured by the domestic value-added rate(DVAR)in exports.Using integrated Chinese microdata(2000-2014),we find this complementarity significantly boosts export DVAR,explaining about one-quarter of its observed growth.Two mechanisms drive this effect:increased use of domestic intermediates and gains in firm productivity.The benefits are especially large for firms with lower human capital and for those in accessible,innovation-peripheral regions,helping narrow productivity gaps across firms and space.Affected firms also exhibit broader export scopes,higher product quality,more diversified destinations,and greater markups-firm-level evidence of GVC upgrading.These findings highlight how external technological linkages drive upgrading and underscore the importance of fostering inter-regional synergies for balanced development.
基金sponsored by the National Natural Science Foundation of China(Grant No.42202205)Natural Science Foundation of Shandong Province,China(Grant No.ZR2021QD072).-。
文摘The vertical heterogeneity of the pore structure in deep coal seams with varying ash yields is a key control for coalbed methane storage and producibility;however,its specific impact on gas adsorption is not clearly defined.The focus of this study is the No.8 coal seam of the Carboniferous Benxi Formation in the Central-Eastern Ordos Basin.By integrating microscopic identification,proximate analysis,gas adsorption(CO_(2),N_(2),and CH_(4)),and the multifractal theory,we quantitatively characterized the nanopore structure(micropores<2 nm and mesopores 2 nm-100 nm)of coal reservoirs with varying ash yields.The results indicate that(1)ash yield is the primary factor that controls the vertical evolution of pore structures in coal seams.In low-ash yield coal seams,the extent of thermal evolution and ash yield jointly constrain the heterogeneity of pore size distribution.In mediumto high-ash yield coal seams,the heterogeneity of pore structure and pore size distribution are predominantly constrained by ash yield.(2)As the ash yield vertically increases,the mesoporous pore volume and specific surface area initially decrease and subsequently increase,while the contribution of micropores to both pore volume and specific surface area continuously diminishes.Consequently,the total pore volume and specific surface area of the coal samples exhibit a two-stage reduction close to an ash yield threshold of approximately 20%.(3)Further,the Langmuir volume for CH_(4)adsorption sharply declines below the 20%threshold,followed by a gradual decrease;in contrast,the Langmuir pressure initially decreases and subsequently increases.Hence,the vertical increase in ash yield constrains the development of pore systems and diminishes pore connectivity,thereby reducing methane adsorption capacity and adversely affecting coalbed methane productivity.(4)Low-ash yield coal reservoirs are characterized by a rapid gas breakthrough and high productivity,whereas medium-ash yield coal reservoirs generally require prolonged depressurization to achieve peak gas production.These findings reveal that in medium-high rank coal,ash yield―and not thermal evolution―is the main factor that controls vertical pore evolution and methane adsorption efficiency.The quantitative ash yield threshold(20%)established in this study provides a practical criterion for evaluating reservoir quality and predicting vertical variations in gas storage potential in the Ordos Basin.
基金supported by the National Key Research and Development Program of China (2021YFB1507401)Qinghai Province Clean Energy Minerals Special Project(2022013004qj004)Geological Survey Project of China Geological Survey (DD20221676, DD20230019)。
文摘The available heat content (stored heat energy) of hot dry rock (HDR) at a depth of 1–10 km in the global land crust is estimated to be 5.06×10~8 EJ,attracting considerable global attention.This paper presents a comprehensive analysis of the geological framework,HDR resource potential,exploration advancements,and the development of enhanced geothermal systems (EGSs) in China.HDR resources are extensively distributed across China.Within the depth range of 3–10 km,China’s estimated potential approximates2.29×10~7 EJ,with a theoretical power generation capacity of approximately 1.67×10^(16) k Wh.Replacing coal power with HDR can help to achieve a net emission reduction of 1.34×10^(16) kg CO_(2) (approximately1.34×10^(13) t),representing an emission reduction efficiency of 94.4%.Based on a development cycle of100 years,the average annual emission reduction reaches 1.34×10^(10) t CO_(2),equivalent to 117%of China’s annual carbon emissions in 2022.Furthermore,in the context of global warming,the development and utilization of HDR,which is feasible in virtually any region worldwide,offers significant potential to support global carbon reduction efforts.China has made substantial progress in HDR exploration in recent years.This paper systematically classifies China’s HDR resources into four genetic types—highly radioactive heat-producing,sedimentary basin,active volcanic,and intensely tectonic zones—and offers detailed exploration insights for each category.Each classification exhibits distinct geological and tectonic characteristics that influence heat source mechanisms and resource distribution.Furthermore,this paper documents significant advances in EGS construction,particularly in the Gonghe Basin on the northeastern margin of the Qianghai-Xizang Plateau and the Matouying uplift in the North China Basin,where successful reservoir stimulation,microseismic monitoring,and experimental power generation have been achieved.Despite these developments,challenges persist,including technical adaptability under complex geological conditions and the economic viability of large-scale HDR development.This paper suggests that future initiatives should emphasize resource exploration,technological research,and policy support to foster sustainable HDR resource development in China,thereby contributing to the global energy transition and environmental sustainability.
基金sponsored by the National Natural Science Foundation of China,China(No.42272171)National Science and Technology Major Project of China,China(No.2017ZX05036).
文摘Dongyuemiao Member shale in the Sichuan Basin,China,is characterized by organic-rich shale intervals with different types of interbeds and accumulation modes.The aim of this study is to elucidate the impact of paleoenvironmental indicators on interbed development.With this aim in mind,we established an interbed classification scheme and quantified the development of different types of interbeds and their frequencies.We categorized the shale interbeds into three types based on interbed type:silt interbeds(SIs),shell fragment interbeds(SFIs),and shell skeleton interbeds(SSIs).The SIs,SFIs,and SSIs are respectively the products of extrabasinal low-density turbidity currents,intrabasinal debris flow,and intrabasinal low-density turbidity currents.We propose that variations in paleoenvironmental conditions primarily influenced the types of interbeds that developed but had minimal impact on the frequency of their development.Models depicting the interbed development within the 1st Submember of Dongyuemiao Member indicate that during the early Dongyuemiao depositional period,under conditions of relatively aridity,weak weathering,high terrigenous input,and strong hydrodynamic activity,SSIs were well developed.In the middle depositional period,as the climate gradually transitioned to more humid conditions,and the weathering intensity and amount of terrestrial input increased,the development of SIs and SFIs significantly increased.During the late depositional period,with a continuous decrease in terrestrial inputs and sedimentation rates,the development of SIs decreased while that of SSIs increased.
基金supported by National Institutes of Health(R35NS137480,R35NS116843,and RF1AG079557)by Dr.Miriam and Sheldon G.Adelson Medical Research Foundation.
文摘The adult subventricular zone of the lateral ventricles and the subgranular zone in the hippocampal dentate gyrus(DG)are the two brain regions where neurogenesis occurs throughout life in the adult mammalian brain(Ming and Song,2011).Adult quiescent hippocampal neural stem cells(NSCs)are bona fide stem cells and,when activated,give rise to newborn granule neurons in the adult brain,which play vital roles in learning,memory,mood,and affective cognition(Bonaguidi et al.,2011;Ming and Song,2011).
基金National Natural Science Foundation of China,No.41771568Social Development Science and Technology Project of Chaoyang District,Beijing,China,No.CYSF1906。
文摘Large regional differences and uneven regional development are fundamental challenges for China. Balanced regional development is an important issue in research on development geography. This study reviews the course of balanced regional development in China and summarizes its characteristics in each period. The results show that inter-regional development in China has undergone successive periods of balanced and unbalanced development. Each period has enhanced social development and contributed to a more balanced regional development. This paper discusses the scientific connotation of balanced regional development, and invokes sustainable development theory to argue that we should pay attention to the differences in resource endowments among regions, and solves the imbalance among the economy, humans, and nature to promote the spatial balance of regional development and green development for better coordination between economy and ecology. The balanced promotion of the well-being of people in each region is the ultimate goal of balanced regional development. We then use concepts from development geography to examine China’s path of balanced regional development from the three perspectives of society, the economy, and ecology. Suggestions are also provided for the balanced development of China’s regions and the improvement of public well-being.
文摘The study offers a conceptual framework illuminating sustainable rural development by a continuous cycling interplay among five interdependent systems,physical,social,economic,knowledge,and creative.The framework is applied to analyze the livelihood transition in the economic system and conversion of traditional knowledge in the creative system for farm households engaged in large cardamom cultivation in Northern mountainous region in Vietnam.This study used a probit model to examine a data set comprising 300 households and confirmed that factors within the social and physical systems(such as labor,access to information,social networks,land use,and transportation infrastructure)determined livelihood transition to tourism employment within the economic system.In addition,the conversion of traditional knowledge in the creative system was found to be contingent upon non-farm employment and credit capital in the economic system,as well as traditional knowledge and knowledge exchange in the knowledge system.This study demonstrates how the sustainable development of rural agriculture can be achieved by converting traditional knowledge and transferring livelihood,contributing to attain Sustainable Development Goals 2(Zero Hunger)and SDG 12(Responsible Consumption and Production).
基金supported by the National Natural Science Foundation of China(Grants No.41931293,42271279,42293271,and 41801175).
文摘China has achieved the poverty reduction goal of the United Nations 2030 Agenda for Sustainable Development 10 years ahead of schedule,contributing significantly to global poverty reduction.Despite extended efforts in poverty elimination,there is a lack of quantitative studies categorizing and comparing poverty-elimination counties(PECs)based on their processes.This study proposes an innovative framework for analyzing PECs’development paths from the perspective of population-land-industry(PLI).We quantify the PLI matching degree of PECs in China during the critical phase of the battle against poverty through a multivariate matching model,classify PECs via K-means clustering according to the consistency in PLI matching degree evolution,and summarize the typical development patterns of PECs.Results indicate that the PLI matching degree of PECs in China increased substantially from 2015 to 2020,particularly in eastern areas,while the western region,including the Qinghai-Xizang Plateau and southwestern Xinjiang,shows untapped potential for improvement.Five types of PECs are identified,with the majority(30.1%)showing sustained moderate PLI matching and a minority(9.6%)experiencing long-term PLI mismatch.Industry is the shortfall of various PECs,and effective strategies to facilitate all types of PECs include the development of emerging businesses and the expansion of secondary and tertiary industries.Additionally,enriching rural labor force and increasing farmland use efficiency are essential for optimal PLI matching and positive interaction,ultimately ensuring poverty elimination and sustainable development.
基金funded by Shanghai Municipal Health and Wellness Commission Health Industry Clinical Research Special Project(202140299).
文摘Background There have been numerous intervention studies focusing on the development of preterm infants,but there has been limited investigation into the home environment as a determinant of developmental outcomes in preterm infants.The aspects and extent to which the home environment affects the early(18 months corrected age)neuropsychological development of preterm infants are still unclear.Aims This study aimed to analyse the effect of the home environment on the neuropsychiatric development of preterm infants at 18 months corrected age after discharge from the neonatal intensive care unit(NICU).It also sought to provide a basis for promoting neuropsychiatric development among preterm infants by improving the home environment.Methods In this retrospective cross-sectional study,275 preterm infants born between January 2019 and January 2022 were followed up for systematic management after discharge from the NICU at Shanghai Children's Hospital.The Home Nurture Environment Questionnaire was used to assess the home environment of the infants and analyse its impact on the developmental quotient(evaluated by the Gesell Developmental Scale)and the rate of developmental delays at 18 months corrected age.Results A total of 41.454%of the infants were extremely preterm.The developmental quotient scores at 18 months corrected age were in the middle of the scale.The language domain had the highest rate of developmental delay(46.182%),followed by the adaptive domain(37.091%).Multiple logistic regression analyses showed that compared with infants in supportive home environments,infants with moderate/unsupportive home environments had significantly elevated risks of development delay:2.162-fold for global(odds ratio(OR)2.162,95% confidence interval(Cl)1.274 to 3.665,p=0.004),2.193-fold for fine motor(OR 2.193,95%CI 1.161 to 4.140,p=0.016),2.249-fold for language(0R 2.249,95%CI 1.336 to 3.786,p=0.002)and 2.042-fold for personal-social(OR 2.042,95%CI 1.149 to 3.628,p=0.015).Conclusions A supportive home environment is a crucial protective factor for the neuropsychological development of preterm infants.It is associated with higher developmental quotient scores and protects against neuropsychiatric delays.Incorporating evaluation and continuous improvement of the home environment into the management framework for preterm infants to promote optimal neurodevelopment is essential.
基金supported by the National Natural Science Foundation of China(32072126 and 32230075)the Shandong Provincial Natural Science Foundation(ZR2019MC005).
文摘Pentatricopeptide repeat(PPR)proteins are a large group of eukaryote-specific RNA-binding proteins that play pivotal roles in plant organelle gene expression.Here,we report the function of PPR21 in mitochondrial intron splicing and its role in maize kernel development.PPR21 is a typical P-type PPR protein targeted to mitochondria.The ppr21 mutants are arrested in embryogenesis and endosperm development,leading to embryo lethality.Null mutations of PPR21 reduce the splicing efficiency of nad2 intron 1,2,and 4 and impair the assembly and activity of mitochondrial complex I.Previous studies show that the P-type PPR protein EMP12 is required for the splicing of identical introns.However,our protein interaction analyses reveal that PPR21 does not interact with EMP12.Instead,both PPR21 and EMP12 interact with the small MutS-related(SMR)domain-containing PPR protein 1(PPR-SMR1)and the short P-type PPR protein 2(SPR2).PPR-SMR1 interacts with SPR2,and both proteins are required for the splicing of many introns in mitochondria,including nad2 intron 1,2,and 4.These results suggest that a PPR21-(PPR-SMR1/SPR2)-EMP12 complex is involved in the splicing of nad2 introns in maize mitochondria.
文摘Purpose–This study summarizes the overall situation of the resources of the national science and technology innovation platform in the railway industry,including the distribution of platform types,supporting institutions,construction sites,professional fields,etc.,to provide a reference for the further improvement and optimization of the national science and technology innovation platform system in the railway industry.Design/methodology/approach–Through literature review,field investigation,expert consultation and other methods,this paper systematically investigates and analyzes the development status of the national science and technology innovation platform in the railway industry.Findings–Taking the national science and technology innovation platform of the railway industry as the research object,this paper investigates and analyzes the construction,development and distribution of the national science and technology innovation platform of railway industry over the years.And the National Engineering Research Center of High-speed Railway and Urban Rail Transit System Technology was taken as an example to introduce its operation effect.Originality/value–China Railway has made great development achievements,with the construction and development of national science and technology innovation platform in the railway industry.In recent years,a large number of national science and technology innovation platforms have been built in the railway industry,which play an important role in railway technological innovation,standard setting and commodification,and Railway Sciences provide strong support for railway technology development.
基金supported by the National Natural Science Foundation of China(Grant No.:82304564)the Liaoning Province Education Department Scientific Research Funding Project(Grant No.:LJKZ0777).
文摘Artificial intelligence(AI)is revolutionizing traditional drug discovery and development models by seamlessly integrating data,computational power,and algorithms.This synergy enhances the efficiency,accuracy,and success rates of drug research,shortens development timelines,and reduces costs.Coupled with machine learning(ML)and deep learning(DL),AI has demonstrated significant advancements across various domains,including drug characterization,target discovery and validation,small molecule drug design,and the acceleration of clinical trials.Through molecular generation techniques,AI facilitates the creation of novel drug molecules,predicting their properties and activities,while virtual screening(VS)optimizes drug candidates.Additionally,AI enhances clinical trial efficiency by predicting outcomes,designing trials,and enabling drug repositioning.However,AI's application in drug development faces challenges,including the need for robust data-sharing mechanisms and the establishment of more comprehensive intellectual property protections for algorithms.AI-driven pharmaceutical companies must also integrate biological sciences and algorithms effectively,ensuring the successful fusion of wet and dry laboratory experiments.Despite these challenges,the potential of AI in drug development remains undeniable.As AI technology evolves and these barriers are addressed,AI-driven therapeutics are poised for a broader and more impactful future in the pharmaceutical industry.
文摘The reform stems from honesty and determination. Since 2005, organ donation and transplantation in China has undergone thorough reform, which complies with legislation requirements and ethical principles established by the World Health Organization(WHO). Reform in China has demonstrated the unwavering confidence and utmost determination of the Chinese government and the Chinese transplantation community. The year 2015 marked a historic turning point when voluntary donations from Chinese citizens became the sole legitimate source for organ transplantation. Since 2015, China has gradually established and refined the “Chinese Mode” and “China System” for organ donation and transplantation, fulfilling its political pledge of reform, and has garnered international recognition, and fostered a social culture which promotes organ donation. This article reviewed the history of reform on organ donation and transplantation in China, presented a new pattern of establishment of organ donation system in the new era of the country, and the direction of advances in the future.
基金supported by the National Key R&D Program of China(2021YFD2100700)National Natural Science Foundation of China(32021005)+1 种基金111 project(BP0719028)Collaborative Innovation Center of Food Safety and Quality Control in Jiangsu Province。
文摘This study endeavors to investigate the effects of Bifidobacterium breve CCFM1078 on bone formation and resorption balance in growing BALB/c mice.Newborn BALB/c mice were assigned to the control group(administration saline)and the CCFM1078 group(administration B.breve CCFM1078,3×10^(9) CFU/day)in 3-,4-,and 5-week tests.All the groups have male and female distinctions.Our findings demonstrate that B.breve CCFM1078 exerts on the dynamic equilibrium between bone formation and resorption during the critical period of growth in mice by modulating the composition of gut microbiota and metabolites(hexadecanamide,linoleoyl ethanolamide,and palmitoyl ethanolamide),the genes and proteins expression related to the growth hormone(GH)/insulin-like growth factors-1(IGF-1)axis and Gs/PKA/CREB signaling pathways,as well as downstream osteogenic and osteoclastic differentiation factors.The effects of B.breve CCFM1078 were different with age and gender dependent.This finding suggests B.breve CCFM1078 may have potential applications in regulating bone metabolism in the growth period population.
文摘This article focuses on the economic dividends of Heilongjiang Province hosting the 9th Asian Winter Games(2025),centered on the ice and snow economy’s high-quality development.Leveraging unique ice and snow resources,Heilongjiang built a“sports events+full industrial chain”model,driving ice and snow tourism upgrading,equipment technology breakthroughs,and cultural brand internationalization.The event optimized the industrial structure by upgrading traditional industries,fostering emerging sectors,and advancing modern services.It also spurred infrastructure leapfrogs(transportation,smart cities,ecology),improved livelihoods(employment,income,public services),and boosted innovation(technology R&D,digital integration,opening-up).Looking ahead,Heilongjiang will use the event’s long-term effects to build a ice and snow-led modern industrial system for high-quality development.
基金supported by the Excellence Research Group Program of the Hubei Provincial Natural Science Foundation(originally termed Basic Science Center Program)(JCKXXM202500016)the Key Program of the National Natural Science Foundation of China(42230812)the National Natural Science Foundation of China(42073068)。
文摘Multiple sets of marine shale sequences occur in western Hubei Province and its adjacent areas within the Middle-Upper Yangtze region,offering substantial resource potential.However,their shale gas preservation conditions differ significantly due to the heterogeneous porosity and fracture system resulting from multistage tectonic reworking.This necessitates developing region-specific evaluation systems and exploitation techniques.Drawing on previous application cases and guided by the research paradigm of geology-engineering integration,this study presents key technologies potentially applicable to shales in western Hubei Province,spanning from reservoir and sweet spot evaluation to fractu ring scheme design and fracturing perfo rmance monitoring.Several insights are gained accordingly.In terms of pore evaluation,the pore heterogeneity caused by compaction and rebound can be quantified using ideal shape coefficients and fractal dimensions,both of which are influenced by structural deformations,thereby guiding reservoir classification.For seismic data interpretation,pre-stack elastic inversion and azimuthal anisotropy inversion can be employed as core techniques,overcoming the limitation of individual post-stack attributes in typically detecting only major faults.Furthermore,the inversion boundaries are constrained using log-seismic joint quality control and geomechanical simulation,contributing to enhanced reliability of sweet spot evaluation and efficient exploration in areas with complex structures.For fracturing scheme design,scientifically formulated well shut-in strategies,tailored to regional geological characteristics,are essential to activate the fracture-matrix imbibition effect.Parameters with vastly different scales used in the design,such as meter-scale fracture halflength and millidarcy-scale fracture conductivity,can be co-optimized using artificial intelligence(AI)algorithms such as the genetic algorithm(GA)and the simultaneous perturbation stochastic approximation(SPSA)algorithm.Dynamic monitoring of fracturing performance can be achieved using trace chemical tracer technology,thereby reducing target ambiguity caused by structural complexity.Research on shale gas in the structurally complex areas of western Hubei faces multiple challenges,spanning from basic geological understanding to development engineering.These challenges create an urgent need for deep interdisciplinary collaboration.Therefore,this study highlights research into geology-engineering integration,aiming to enhance the efficiency of shale gas exploration and development in western Hubei.
基金Supported by the PetroChina Scentific and Technological Projects(2023ZZ082023ZZ28)。
文摘Currently,unconventional reservoirs are characterized by low single well-controlled reserves,high initial production but fast production decline.This paper sorts out the problems of energy dispersion and limited length and height of main hydraulic fractures induced in staged multi-cluster fracturing,and proposes an innovative concept of“energy-focused fracturing development”.The technical connotation,theoretical model,and core techniques of energy-focused fracturing development are systematically examined,and the implementation path of this technology is determined.The energy-focused fracturing development technology incorporates the techniques such as geology-engineering integrated design,perforation optimization design,fracturing process design,and drainage engineering control.It transforms the numerous,short and dense hydraulic fractures to limited,long and sparse fractures.It focuses on fracturing energy,and aims to improve the fracture length,height and lateral width,and the proppant long-distance transportation capacity,thus enhancing the single well-controlled reserves and development effect.The energy-focused fracturing development technology has been successfully applied in the carbonate reservoirs in buried hill,shallow coalbed methane reservoirs,and coal-rock gas reservoirs in China,demonstrating the technology's promising application.It is concluded that the energy-focused fracturing development technology can significantly increase the single well production and estimated ultimate recovery(EUR),and will be helpful for efficiently developing low-permeability,unconventional and low-grade resources in China.
