This study employs deformation monitoring data acquired during the construction of the Haoji railway large-scale bridge to investigate the displacement behavior of the subgrades,catenary columns,and tracks.Emphasis is...This study employs deformation monitoring data acquired during the construction of the Haoji railway large-scale bridge to investigate the displacement behavior of the subgrades,catenary columns,and tracks.Emphasis is placed on data acquisition and processing methods using total stations and automated monitoring systems.Through a comprehensive analysis of lateral,longitudinal,and vertical displacement data from 26 subgrade monitoring points,catenary columns,and track sections,this research evaluates how construction activities influence railway structures.The results show that displacement variations in the subgrades,catenary columns,and tracks remained within the established alert thresholds,exhibiting stable deformation trends and indicating that any adverse environmental impact was effectively contained.Furthermore,this paper proposes an early warning mechanism based on an automated monitoring system,which can promptly detect abnormal deformations and initiate emergency response procedures,thereby ensuring the safe operation of the railway.The integration of big data analysis and deformation prediction models offers a practical foundation for future safety management in railway construction.展开更多
1.Introduction Cancer continues to be a major cause of global mortality rates,with conventional treatments such as chemotherapy and radiotherapy exhibiting inconsistent efficacy,high costs,and considerable side effect...1.Introduction Cancer continues to be a major cause of global mortality rates,with conventional treatments such as chemotherapy and radiotherapy exhibiting inconsistent efficacy,high costs,and considerable side effects.Over the past decade,a promising alternative has emerged:cancer immunotherapy,which leverages the body's immune system to identify and eradicate cancer cells[1].展开更多
Aging and regeneration represent complex biological phenomena that have long captivated the scientific community.To fully comprehend these processes,it is essential to investigate molecular dynamics through a lens tha...Aging and regeneration represent complex biological phenomena that have long captivated the scientific community.To fully comprehend these processes,it is essential to investigate molecular dynamics through a lens that encompasses both spatial and temporal dimensions.Conventional omics methodologies,such as genomics and transcriptomics,have been instrumental in identifying critical molecular facets of aging and regeneration.However,these methods are somewhat limited,constrained by their spatial resolution and their lack of capacity to dynamically represent tissue alterations.The advent of emerging spatiotemporal multi-omics approaches,encompassing transcriptomics,proteomics,metabolomics,and epigenomics,furnishes comprehensive insights into these intricate molecular dynamics.These sophisticated techniques facilitate accurate delineation of molecular patterns across an array of cells,tissues,and organs,thereby offering an in-depth understanding of the fundamental mechanisms at play.This review meticulously examines the significance of spatiotemporal multi-omics in the realms of aging and regeneration research.It underscores how these methodologies augment our comprehension of molecular dynamics,cellular interactions,and signaling pathways.Initially,the review delineates the foundational principles underpinning these methods,followed by an evaluation of their recent applications within the field.The review ultimately concludes by addressing the prevailing challenges and projecting future advancements in the field.Indubitably,spatiotemporal multi-omics are instrumental in deciphering the complexities inherent in aging and regeneration,thus charting a course toward potential therapeutic innovations.展开更多
Laser powder bed fusion(LPBF)is a popular additive manufacturing(AM)technique to fabricate metal components.LPBF Ti alloys often exhibit high strength but poor ductility.In this study,we report that trace Y_(2)O_(3) n...Laser powder bed fusion(LPBF)is a popular additive manufacturing(AM)technique to fabricate metal components.LPBF Ti alloys often exhibit high strength but poor ductility.In this study,we report that trace Y_(2)O_(3) nanoparticles added to a pre-alloyed Ti-4Al-4V(Ti44)powder provides an excellent feedstock for LPBF.As-built Ti44-Y_(2)O_(3) materials exhibited a strength-ductility combination that is slightly better than heat-treated LPBF Ti64.Some Y_(2)O_(3) particles may have melted or decomposed during LPBF.From electron microscopy,the addition of Y_(2)O_(3) refined α’martensite laths and weakened variant preference during β→α’transformation.Based on in situ synchrotron X-ray diffraction and elastic-viscoplastic self-consistent(EVPSC)modeling,(c+a)slip was more active in as-built Ti44-Y_(2)O_(3) than in as-built Ti64 or Ti44.This work demonstrates that LPBF can be an excellent method to fabricate metal-nanoparticle composite materials.展开更多
The post-fabrication machining of additively manufactured biomedical parts is essential for achieving dimensional accuracy.However,conventional machining encounters issues in dealing with the growing demand for surfac...The post-fabrication machining of additively manufactured biomedical parts is essential for achieving dimensional accuracy.However,conventional machining encounters issues in dealing with the growing demand for surface quality and the inherent defects of parts.To improve the machining quality,the correlation between material variations and ultrasonic machining quality is investigated in terms of material properties.This variation induced by additive strategies is experimentally revealed and the mechanism for this difference is further explained through molten pool dynamic simulation.In addition,to elucidate the unique machining advantages,a hybrid cutting simulation is implemented to analyze the improving behavior of ultrasonic vibration on the common defects of additively manufactured parts.Taken together,this study demonstrates the role that material property differences play in post-fabrication machining and validates the superiority of ultrasonic machining as a post-fabrication machining method for additively manufactured parts.展开更多
This study focuses on designing a solution to the perennial issue of clothing fit in Fashion Industry using tools offered by digital technology and statistical analysis, in particular, the data gathered on Asian women...This study focuses on designing a solution to the perennial issue of clothing fit in Fashion Industry using tools offered by digital technology and statistical analysis, in particular, the data gathered on Asian women (Bangladeshi and Chinese). The study reveals that managing information can significantly enhance the capability of the industry to cater to the needs of its consumers and increase diversity. It centers on the effectiveness of turning dressmaking patterns into digital ones, thus transecting from traditional cutting and stitching to remote techniques. This entails the requirement to have correct self-measures and probable errors, which can arise in the process. Thus, with the help of regression analysis, the study identifies, which measurements are incorrect and influence the fit of the clothes, and, therefore, digital pattern creation is more accurate. Altogether, it can be observed how digitalization and statistical methods are crucial to transforming the way clothes are created to approach an ideal standard of measurements that fulfill every customer’s needs to make operational and efficient the clothing sector.展开更多
CoCrMoW alloys with different nitrogen(N)additions(0,0.05,0.1,and 0.2 wt%)were prepared via laser powder bed fusion(LPBF).The effects of N content on the microstructure and mechanical properties were investigated.The ...CoCrMoW alloys with different nitrogen(N)additions(0,0.05,0.1,and 0.2 wt%)were prepared via laser powder bed fusion(LPBF).The effects of N content on the microstructure and mechanical properties were investigated.The results indicate that the LPBFed CoCrMoW alloy with 0.1 wt%N addition(0.1 N alloy)shows the best combination of mechanical properties with a yield strength of~983 MPa and an elongation of~19%.Both the LPBF process and the N addition impose great effects on suppressing theγtoεmartensitic transformation,resulting in a decrease in the width and amount ofεlaths/stacking faults.Besides,the N addition promotes the segregation of elements Mo,W,and Si along the cellular sub-grain boundaries(CBs),forming fine and discontinuous precipitates rich in Mo,W and Si along the CBs in the 0.1 N alloy,but dense and continuous(Mo,W)5Si_(3)precipitates along the CBs in the 0.2 N alloy.The(Mo,W)5Si_(3)precipitates with a tetragonal structure were observed and characterized for the first time in the Co-Cr based alloys.The negative mixing enthalpy between the non-metallic elements N,Si and the metallic elements Mo,W,Cr,and the rapid solidification induced segregation of high melting point elements such as Mo and W along CBs during LPBF process,synergistically contribute to the chemical heterogeneity in the alloys.The pure FCC matrix,the slightly increased segregation of Mo,W,Si elements and fine precipitates along the CBs contribute to the good combination of strength and elongation of the 0.1 N alloy.However,though pure FCC phase was present in the 0.2 N alloy,the dense and continuous(Mo,W)5Si_(3)precipitates along CBs acted as nucleation sites for cracks,deteriorating the elongation of the alloy.Overall,it is possible to tune the mechanical properties of the LPBFed CoCrMoW alloy by adjusting the local chemical heterogeneity.展开更多
Not always climate and cultural contexts are discussed at the forefront of architectural discussions on traditional or vernacular architecture,nevertheless,the construction material also plays a significant part in de...Not always climate and cultural contexts are discussed at the forefront of architectural discussions on traditional or vernacular architecture,nevertheless,the construction material also plays a significant part in defining places’architectural languages.Building from the local materials is an essential ingredient of the local distinctiveness,whilst forming the architectural grand gesture in its context.In Siwa oasis,salt architecture has formed that architectural grand gesture.The vernacular vocabularies adopted by old Bedouins using salt bricks generated Siwa’s unique spirit.In this paper,some examples are illustrated based on a series of site visits to three main sites in Siwa,namely:Old Shali,Abu Shuruf,and Aghourmy.This shows the evolution of Siwa’s vernacular architecture and the role of the architectural language or detrimental effect on the overall quality of architecture.From the site visits,it was observed that building with the traditional technique is now becoming abandoned in Siwa,explained by the local builders to be due to the huge costs required;forcing them to shifting to modern architecture.The influx to building using modern techniques has led to a significant transformation in the urban morphology and spirit of Siwa.Herein lies the scope of this paper:to discuss the impact of the evolution of vernacular architecture on the overall quality of architecture in Siwa and thus identifying the problems which will lead to policy formulation and guidelines for the redevelopment of Siwa in order to“revitalize/resuscitate”its vernacular style accordingly.展开更多
Osteoporosis is a major cause of bone fracture and can be characterised by both mass loss and microstructure deterioration of the bone.The modern way of osteoporosis assessment is through the measurement of bone miner...Osteoporosis is a major cause of bone fracture and can be characterised by both mass loss and microstructure deterioration of the bone.The modern way of osteoporosis assessment is through the measurement of bone mineral density,which is not able to unveil the pathological condition from the mesoscale aspect.To obtain mesoscale information from computed tomography(CT),the super-resolution(SR)approach for volumetric imaging data is required.A deep learning model AESR3D is proposed to recover high-resolution(HR)Micro-CT from low-resolution Micro-CT and implement an unsupervised segmentation for better trabecular observation and measurement.A new regularisation overcomplete autoencoder framework for the SR task is proposed and theoretically analysed.The best performance is achieved on structural similarity measure of trabecular CT SR task compared with the state-of-the-art models in both natural and medical image SR tasks.The HR and SR images show a high correlation(r=0.996,intraclass correlation coefficients=0.917)on trabecular bone morphological indicators.The results also prove the effectiveness of our regularisation framework when training a large capacity model.展开更多
Ammonia is a promising zero-carbon alternative fuel.Direct ammonia fuel cells (DAFCs),as an efficient ammonia-fueled power system,have an extremely high application value in the field of transportation for decarboniza...Ammonia is a promising zero-carbon alternative fuel.Direct ammonia fuel cells (DAFCs),as an efficient ammonia-fueled power system,have an extremely high application value in the field of transportation for decarbonization.Metals are essential components for catalysts and electrolytes in DAFCs,with catalysts being critical to their overall performance.Currently,ammoniafueled solid oxide fuel cells with Ni-based catalysts have reached peak power densities exceeding 1000 mW.cm^(-2).In the case of anion exchange membrane fuel cells,platinum-group metal catalysts can achieve a peak power density of 410 mW.cm^(-2).Despite these advancements,further development of more efficient,stable,and cost-effective catalysts is necessary to meet the demands for high efficiency and power density in transportation power systems.This review comprehensively summarizes the recent advancements of metal materials in DAFCs,as well as the potential applications of DAFCs in the transportation sector.展开更多
Drug resistance poses a significant challenge to effective long-term treatment across various medical fields.This study proposed a feasible strategy to enhance lysosomal alkalinization by transporting mitochondria-tar...Drug resistance poses a significant challenge to effective long-term treatment across various medical fields.This study proposed a feasible strategy to enhance lysosomal alkalinization by transporting mitochondria-targeting quaternary ammonium salts into lysosomes,creating a deprotonated environment.This environment allows drugs to bypass protonation issues in lysosomes,thereby reversing drug resistance and improving therapeutic efficacy.As a proof of concept,a quaternary ammonium salt-based pH indicator was developed,berberrubine(BRB),enhancing the action of the anticancer drug hydroxycamptothecin(HCPT)in resistant cells.BRB-induced alkalinization increased lysosomal pH and deactivated lysosomal activity,enabling HCPT to bypass protonation constraints.This enhancement markedly improved the anticancer efficacy of HCPT in resistant cells,providing an innovative approach to address drug resistance and advancing therapeutic technologies.展开更多
Corex is an alternative ironmaking process and raceway is one of the important areas to maintain the stability of the furnace. The raceway parameters are well established for blast furnace operation. But for Corex pro...Corex is an alternative ironmaking process and raceway is one of the important areas to maintain the stability of the furnace. The raceway parameters are well established for blast furnace operation. But for Corex process,it has not yet been established and optimized. Thus,a mathematical model was developed to determine various raceway parameters such as RAFT （raceway adiabatic flame temperature）,tuyere gas velocity and kinetic energy. The model provides an idea about the raceway geometry,zone temperature and kinetic energy accumulated in tuyere gas. Besides,all the raceway parameters have been analyzed to find out their effects on the Corex process. It is found that RAFT influences the gasification reaction kinetics and higher RAFT generates more CO in reduction gas,which improves the metallisation degree of the DRI in shaft. It is also found that increased gas velocity and kinetic energy generate more fines and demand more coke to maintain char bed permeability. High coke rate increases the production cost and lowers the production of hot metal.展开更多
Rechargeable zinc-air batteries(ZABs)are a promising energy conversion device,which rely critically on electrocatalysts to accelerate their rate-determining reactions such as oxygen reduction(ORR)and oxygen evolution ...Rechargeable zinc-air batteries(ZABs)are a promising energy conversion device,which rely critically on electrocatalysts to accelerate their rate-determining reactions such as oxygen reduction(ORR)and oxygen evolution reactions(OER).Herein,we fabricate a range of bifunctional M-N-C(metal-nitrogen-carbon)catalysts containing M-Nx coordination sites and M/MxC nanoparticles(M=Co,Fe,and Cu)using a new class ofγ-cyclodextrin(CD)based metal-organic framework as the precursor.With the two types of active sites interacting with each other in the catalysts,the obtained Fe@C-FeNC and Co@C-CoNC display superior alkaline ORR activity in terms of low half-wave(E1/2)potential(~0.917 and 0.906 V,respectively),which are higher than Cu@C-CuNC(~0.829 V)and the commercial Pt/C(~0.861 V).As a bifunctional electrocatalyst,the Co@C-CoNC exhibits the best performance,showing a bifunctional ORR/OER overpotential(ΔE)of~0.732 V,which is much lower than that of Fe@C-FeNC(~0.831 V)and Cu@C-CuNC(~1.411 V),as well as most of the robust bifunctional electrocatalysts reported to date.Synchrotron X-ray absorption spectroscopy and density functional theory simulations reveal that the strong electronic correlation between metallic Co nanoparticles and the atomic Co-N4 sites in the Co@C-CoNC catalyst can increase the d-electron density near the Fermi level and thus effectively optimize the adsorption/desorption of intermediates in ORR/OER,resulting in an enhanced bifunctional electrocatalytic performance.The Co@C-CoNC-based rechargeable ZAB exhibited a maximum power density of 162.80 mW cm^(−2) at 270.30 mA cm^(−2),higher than the combination of commercial Pt/C+RuO2(~158.90 mW cm^(−2) at 265.80 mA cm^(−2))catalysts.During the galvanostatic discharge at 10 mA cm^(−2),the ZAB delivered an almost stable discharge voltage of 1.2 V for~140 h,signifying the virtue of excellent bifunctional ORR/OER electrocatalytic activity.展开更多
The coronavirus disease 2019(COVID-19)pandemic has caused a surge in demand for face masks,with the massive consumption of masks leading to an increase in resource-related and environmental con-cerns.In this work,we f...The coronavirus disease 2019(COVID-19)pandemic has caused a surge in demand for face masks,with the massive consumption of masks leading to an increase in resource-related and environmental con-cerns.In this work,we fabricated meltblown polypropylene(mb-PP)-based high-performance planar face masks and investigated the effects of six commonly used disinfection methods and various mask-wearing periods on the reusability of these masks.The results show that,after three cycles of treatment using hot water at 70℃ for 30 min,which is one of the most scalable,user-friendly methods for viral disinfection,the particle filtration efficiency(PFE)of the mask remained almost unchanged.After mask wearing for 24 h and subsequent disinfection using the same treatment procedures,the PFE decreased to 91.3%;the average number of bacterial and fungal colonies was assessed to be 9.2 and 51.6 colony-forming units per gram(CFU∙g^(-1)),respectively;and coliform and pyogenic bacteria were not detected.Both the PFE and the microbial indicators are well above the standard for reusable masks after disinfection.Schlieren pho-tography was then used to assess the capabilities of used and disinfected masks during use;it showed that the masks exhibit a high performance in suppressing the spread of breathed air.展开更多
Long-emission carbon dots(CDs) is triggering immense enthusiasm on account of their intrinsic merits of high chemical stability and excellent optical properties.In this study,a facile and rapid approach was developed ...Long-emission carbon dots(CDs) is triggering immense enthusiasm on account of their intrinsic merits of high chemical stability and excellent optical properties.In this study,a facile and rapid approach was developed for the preparation of barium-doped carbon dots(Ba-CDs) with yellow fluo rescence emission and high quantum yields.Surface chemistry and the chemical architecture of the Ba-CDs was revealed under various spectroscopic methods.This work provides more insights into the effects of charge transfer caused by Ba heteroatoms,which is considered as the most challenging step in the investigation on luminescence mechanism.Remarkably,the prepared Ba-CDs were successfully applied as fluorescent probes in the detection of trace water in organic solvents(ethanol,isopropanol,acetone,tetrahydrofuran).Comparing with traditional fluorescent probes for water detection in organic solvents,Ba-CDs detection provides a more sensitive,much faster and more economical approach.展开更多
With the rapid development of the Internet,the amount of data recorded on the Internet has increased dramatically.It is becoming more and more urgent to effectively obtain the specific information we need from the vas...With the rapid development of the Internet,the amount of data recorded on the Internet has increased dramatically.It is becoming more and more urgent to effectively obtain the specific information we need from the vast ocean of data.In this study,we propose a novel collaborative filtering algorithm for generating recommendations in e-commerce.This study has two main innovations.First,we propose a mechanismthat embeds temporal behavior information to find a neighbor set in which each neighbor has a very significant impact on the current user or item.Second,we propose a novel collaborative filtering algorithm by injecting the neighbor set into probability matrix factorization.We compared the proposed method with several state-of-the-art alternatives on real datasets.The experimental results show that our proposed method outperforms the prevailing approaches.展开更多
The precise determination of zona pellucida (ZP) hardness is largely unknown due to the lack of appropriate measuring and modelling methods. In this study, we have used experimental and theoretical models to describe ...The precise determination of zona pellucida (ZP) hardness is largely unknown due to the lack of appropriate measuring and modelling methods. In this study, we have used experimental and theoretical models to describe the mechanical behavior of a single oocyte cell to improve the assisted reproductive technology (ART) outcomes by assessing oocyte/embryo quality. This paper presents the development of: i) a microinjection model to estimate the force of ZP penetration, ii) a micropipette aspiration model to determine the corresponding hardness, and iii) an experimental procedure to generate the required data for these two models. Our results show that the estimated penetration force provides a performance target for the penetration process during intracytoplasmic sperm injection (ICSI), while the estimated corresponding hardness serves as an indicator of the extent of deformation sustained by the oocyte prior to penetration. Evaluation of these results shows that a routine assessment of ZP hardness under microinjection would allow for the identification of certain oocyte pools for which further manipulation is recommended in order to improve injection, hatching and finally ART outcomes.展开更多
In this paper, a high-performance and low-complexity luminance transient improvement （LTI） algorithm is proposed and efficiently implemented on field programmable gate army （FPGA） devices, which can be widely used...In this paper, a high-performance and low-complexity luminance transient improvement （LTI） algorithm is proposed and efficiently implemented on field programmable gate army （FPGA） devices, which can be widely used to enhance the sharpness of digital video. The proposed algorithm generates the cor- rection signal by using the difference of the outputs of two Gaussian filters with different variances, and then modulates the correction signal adaptively according to the local contrast information of video frames. A 2-D min/max nonlinear filter is employed to suppress overshoots around edges. The proposed algorithm is thoroughly confirmed by experiments and compared with other algorithms on irrkages, which produces steeper edges and better visual quality while suppressing noise and artifacts. And the hardware architecture suitable for FPGA implementation is optimized based on the property of the algorithm and proves to be effective and efficient in many respects, such as resource consumption, performance and reconfigura- bility. The specific implementation details on both Xilinx and Ahera FPGA devices are also described in this paper.展开更多
This paper describes an approach to identify epicyclic and tricyclic motion during projectile flight caused by mass asymmetries in spinstabilized projectiles. Flight video was captured following projectile launch of s...This paper describes an approach to identify epicyclic and tricyclic motion during projectile flight caused by mass asymmetries in spinstabilized projectiles. Flight video was captured following projectile launch of several M110A2E1 155 mm artillery projectiles. These videos were then analyzed using the automated flight video analysis method to attain their initial position and orientation histories.Examination of the pitch and yaw histories clearly indicates that in addition to epicyclic motion's nutation and precession oscillations, an even faster wobble amplitude is present during each spin revolution, even though some of the amplitudes of the oscillation are smaller than 0.02 degree.The results are compared to a sequence of shots where little appreciable mass asymmetries were present, and only nutation and precession frequencies are predominantly apparent in the motion history results. Magnitudes of the wobble motion are estimated and compared to product of inertia measurements of the asymmetric projectiles.展开更多
文摘This study employs deformation monitoring data acquired during the construction of the Haoji railway large-scale bridge to investigate the displacement behavior of the subgrades,catenary columns,and tracks.Emphasis is placed on data acquisition and processing methods using total stations and automated monitoring systems.Through a comprehensive analysis of lateral,longitudinal,and vertical displacement data from 26 subgrade monitoring points,catenary columns,and track sections,this research evaluates how construction activities influence railway structures.The results show that displacement variations in the subgrades,catenary columns,and tracks remained within the established alert thresholds,exhibiting stable deformation trends and indicating that any adverse environmental impact was effectively contained.Furthermore,this paper proposes an early warning mechanism based on an automated monitoring system,which can promptly detect abnormal deformations and initiate emergency response procedures,thereby ensuring the safe operation of the railway.The integration of big data analysis and deformation prediction models offers a practical foundation for future safety management in railway construction.
基金supported by Australian Centre for AI in Medical Innovation(ACAMI)funded by the Victoria State Government,National University of Singapore(NUHSRO/2020/133/Startup/08,NUHSRO/2023/008/NUSMed/TCE/LOA,NUHSRO/2021/034/TRP/09/Nanomedicine,NUHSRO/2021/044/Kickstart/09/LOA,and 230173-A0001)National Medical Research Council(MOH-001388-00,CG21APR1005,MOH-001500-00,and MOH-001609-00)+1 种基金Singapore Ministry of Education(MOE-000387-00 and MOET32023-0005)National Research Foundation(NRF-000352-00)。
文摘1.Introduction Cancer continues to be a major cause of global mortality rates,with conventional treatments such as chemotherapy and radiotherapy exhibiting inconsistent efficacy,high costs,and considerable side effects.Over the past decade,a promising alternative has emerged:cancer immunotherapy,which leverages the body's immune system to identify and eradicate cancer cells[1].
基金supported by the Leading Innovative and Entrepreneur Team Introduction Program of Zhejiang(2023R01002)the National Natural Science Foundation of China(82271629,82301790)。
文摘Aging and regeneration represent complex biological phenomena that have long captivated the scientific community.To fully comprehend these processes,it is essential to investigate molecular dynamics through a lens that encompasses both spatial and temporal dimensions.Conventional omics methodologies,such as genomics and transcriptomics,have been instrumental in identifying critical molecular facets of aging and regeneration.However,these methods are somewhat limited,constrained by their spatial resolution and their lack of capacity to dynamically represent tissue alterations.The advent of emerging spatiotemporal multi-omics approaches,encompassing transcriptomics,proteomics,metabolomics,and epigenomics,furnishes comprehensive insights into these intricate molecular dynamics.These sophisticated techniques facilitate accurate delineation of molecular patterns across an array of cells,tissues,and organs,thereby offering an in-depth understanding of the fundamental mechanisms at play.This review meticulously examines the significance of spatiotemporal multi-omics in the realms of aging and regeneration research.It underscores how these methodologies augment our comprehension of molecular dynamics,cellular interactions,and signaling pathways.Initially,the review delineates the foundational principles underpinning these methods,followed by an evaluation of their recent applications within the field.The review ultimately concludes by addressing the prevailing challenges and projecting future advancements in the field.Indubitably,spatiotemporal multi-omics are instrumental in deciphering the complexities inherent in aging and regeneration,thus charting a course toward potential therapeutic innovations.
基金supported by the National Key Research and Development Program of China(No.2021YFB3702602)the National Natural Science Foundation of Chin a(No.U2032124)the support by the Ministry of Education,Singapore,under its Academic Research Fund Tier 1(No.A-0009475-01-00).
文摘Laser powder bed fusion(LPBF)is a popular additive manufacturing(AM)technique to fabricate metal components.LPBF Ti alloys often exhibit high strength but poor ductility.In this study,we report that trace Y_(2)O_(3) nanoparticles added to a pre-alloyed Ti-4Al-4V(Ti44)powder provides an excellent feedstock for LPBF.As-built Ti44-Y_(2)O_(3) materials exhibited a strength-ductility combination that is slightly better than heat-treated LPBF Ti64.Some Y_(2)O_(3) particles may have melted or decomposed during LPBF.From electron microscopy,the addition of Y_(2)O_(3) refined α’martensite laths and weakened variant preference during β→α’transformation.Based on in situ synchrotron X-ray diffraction and elastic-viscoplastic self-consistent(EVPSC)modeling,(c+a)slip was more active in as-built Ti44-Y_(2)O_(3) than in as-built Ti64 or Ti44.This work demonstrates that LPBF can be an excellent method to fabricate metal-nanoparticle composite materials.
基金supported by the National Natural Science Foun-dation of China(Nos.51975112 and52375412)the Fundamental Research Funds for Central Universities(No.N2203003)the Singapore Ministry of Education(Grant No.A-8001225-00-00).
文摘The post-fabrication machining of additively manufactured biomedical parts is essential for achieving dimensional accuracy.However,conventional machining encounters issues in dealing with the growing demand for surface quality and the inherent defects of parts.To improve the machining quality,the correlation between material variations and ultrasonic machining quality is investigated in terms of material properties.This variation induced by additive strategies is experimentally revealed and the mechanism for this difference is further explained through molten pool dynamic simulation.In addition,to elucidate the unique machining advantages,a hybrid cutting simulation is implemented to analyze the improving behavior of ultrasonic vibration on the common defects of additively manufactured parts.Taken together,this study demonstrates the role that material property differences play in post-fabrication machining and validates the superiority of ultrasonic machining as a post-fabrication machining method for additively manufactured parts.
文摘This study focuses on designing a solution to the perennial issue of clothing fit in Fashion Industry using tools offered by digital technology and statistical analysis, in particular, the data gathered on Asian women (Bangladeshi and Chinese). The study reveals that managing information can significantly enhance the capability of the industry to cater to the needs of its consumers and increase diversity. It centers on the effectiveness of turning dressmaking patterns into digital ones, thus transecting from traditional cutting and stitching to remote techniques. This entails the requirement to have correct self-measures and probable errors, which can arise in the process. Thus, with the help of regression analysis, the study identifies, which measurements are incorrect and influence the fit of the clothes, and, therefore, digital pattern creation is more accurate. Altogether, it can be observed how digitalization and statistical methods are crucial to transforming the way clothes are created to approach an ideal standard of measurements that fulfill every customer’s needs to make operational and efficient the clothing sector.
基金the financial support from National Natural Science Foundation of China[grant number 52171130(S.Ni)]Huxiang Youth Talents Support Program[grant number 2021RC3002(S.Ni)]+1 种基金the financial support from the Research Office and Research Institute of Advanced Manufacturing of the Hong Kong Polytechnic University[grant numbers P0039966 and P0041361]support from the Royal Society in the UK under Grant No.IES\R3\223190.
文摘CoCrMoW alloys with different nitrogen(N)additions(0,0.05,0.1,and 0.2 wt%)were prepared via laser powder bed fusion(LPBF).The effects of N content on the microstructure and mechanical properties were investigated.The results indicate that the LPBFed CoCrMoW alloy with 0.1 wt%N addition(0.1 N alloy)shows the best combination of mechanical properties with a yield strength of~983 MPa and an elongation of~19%.Both the LPBF process and the N addition impose great effects on suppressing theγtoεmartensitic transformation,resulting in a decrease in the width and amount ofεlaths/stacking faults.Besides,the N addition promotes the segregation of elements Mo,W,and Si along the cellular sub-grain boundaries(CBs),forming fine and discontinuous precipitates rich in Mo,W and Si along the CBs in the 0.1 N alloy,but dense and continuous(Mo,W)5Si_(3)precipitates along the CBs in the 0.2 N alloy.The(Mo,W)5Si_(3)precipitates with a tetragonal structure were observed and characterized for the first time in the Co-Cr based alloys.The negative mixing enthalpy between the non-metallic elements N,Si and the metallic elements Mo,W,Cr,and the rapid solidification induced segregation of high melting point elements such as Mo and W along CBs during LPBF process,synergistically contribute to the chemical heterogeneity in the alloys.The pure FCC matrix,the slightly increased segregation of Mo,W,Si elements and fine precipitates along the CBs contribute to the good combination of strength and elongation of the 0.1 N alloy.However,though pure FCC phase was present in the 0.2 N alloy,the dense and continuous(Mo,W)5Si_(3)precipitates along CBs acted as nucleation sites for cracks,deteriorating the elongation of the alloy.Overall,it is possible to tune the mechanical properties of the LPBFed CoCrMoW alloy by adjusting the local chemical heterogeneity.
文摘Not always climate and cultural contexts are discussed at the forefront of architectural discussions on traditional or vernacular architecture,nevertheless,the construction material also plays a significant part in defining places’architectural languages.Building from the local materials is an essential ingredient of the local distinctiveness,whilst forming the architectural grand gesture in its context.In Siwa oasis,salt architecture has formed that architectural grand gesture.The vernacular vocabularies adopted by old Bedouins using salt bricks generated Siwa’s unique spirit.In this paper,some examples are illustrated based on a series of site visits to three main sites in Siwa,namely:Old Shali,Abu Shuruf,and Aghourmy.This shows the evolution of Siwa’s vernacular architecture and the role of the architectural language or detrimental effect on the overall quality of architecture.From the site visits,it was observed that building with the traditional technique is now becoming abandoned in Siwa,explained by the local builders to be due to the huge costs required;forcing them to shifting to modern architecture.The influx to building using modern techniques has led to a significant transformation in the urban morphology and spirit of Siwa.Herein lies the scope of this paper:to discuss the impact of the evolution of vernacular architecture on the overall quality of architecture in Siwa and thus identifying the problems which will lead to policy formulation and guidelines for the redevelopment of Siwa in order to“revitalize/resuscitate”its vernacular style accordingly.
基金Beijing Natural Science Foundation-Haidian original Innovation Joint Foundation,Grant/Award Number:L192016Joint Funds of the National Natural Science Foundation of China,Grant/Award Number:U21A20489+3 种基金National Natural Science Foundation of China,Grant/Award Number:62003330Shenzhen Fundamental Research Funds,Grant/Award Numbers:JCYJ20220818101608019,JCYJ20190807170407391,JCYJ20180507182415428Natural Science Foundation of Guangdong Province,Grant/Award Number:2019A1515011699Guangdong-Hong Kong-Macao Joint Laboratory of Human-Machine Intelligence-Synergy Systems,Shenzhen Institute of Advanced Technology。
文摘Osteoporosis is a major cause of bone fracture and can be characterised by both mass loss and microstructure deterioration of the bone.The modern way of osteoporosis assessment is through the measurement of bone mineral density,which is not able to unveil the pathological condition from the mesoscale aspect.To obtain mesoscale information from computed tomography(CT),the super-resolution(SR)approach for volumetric imaging data is required.A deep learning model AESR3D is proposed to recover high-resolution(HR)Micro-CT from low-resolution Micro-CT and implement an unsupervised segmentation for better trabecular observation and measurement.A new regularisation overcomplete autoencoder framework for the SR task is proposed and theoretically analysed.The best performance is achieved on structural similarity measure of trabecular CT SR task compared with the state-of-the-art models in both natural and medical image SR tasks.The HR and SR images show a high correlation(r=0.996,intraclass correlation coefficients=0.917)on trabecular bone morphological indicators.The results also prove the effectiveness of our regularisation framework when training a large capacity model.
基金supported by the National Natural Science Foundation of China (No.T2241003)。
文摘Ammonia is a promising zero-carbon alternative fuel.Direct ammonia fuel cells (DAFCs),as an efficient ammonia-fueled power system,have an extremely high application value in the field of transportation for decarbonization.Metals are essential components for catalysts and electrolytes in DAFCs,with catalysts being critical to their overall performance.Currently,ammoniafueled solid oxide fuel cells with Ni-based catalysts have reached peak power densities exceeding 1000 mW.cm^(-2).In the case of anion exchange membrane fuel cells,platinum-group metal catalysts can achieve a peak power density of 410 mW.cm^(-2).Despite these advancements,further development of more efficient,stable,and cost-effective catalysts is necessary to meet the demands for high efficiency and power density in transportation power systems.This review comprehensively summarizes the recent advancements of metal materials in DAFCs,as well as the potential applications of DAFCs in the transportation sector.
基金supported by Young Elite Scientists Sponsorship Program by China Association for Science and Technology(No.CACM-2023-QNRC1–02)Shandong Province Key R&D Program(Major Technological Innovation Project)(No.2021CXGC010501)+6 种基金National Natural Science Foundation of China(No.22107059)Natural Science Foundation of Shandong Province(No.ZR2021QH057)Program for Youth Innovation Technology in Colleges and Universities of Shandong Province of China(No.2021KJ035)Taishan Scholars Program(No.TSQN202211221)Shandong Science Fund for Excellent Young Scholars(No.ZR2022YQ66)Funded by Shandong Postdoctoral Science Foundation(No.SDCX-ZG-202400084)the National Administration of Traditional Chinese Medicine Young Qihuang Scholar Project。
文摘Drug resistance poses a significant challenge to effective long-term treatment across various medical fields.This study proposed a feasible strategy to enhance lysosomal alkalinization by transporting mitochondria-targeting quaternary ammonium salts into lysosomes,creating a deprotonated environment.This environment allows drugs to bypass protonation issues in lysosomes,thereby reversing drug resistance and improving therapeutic efficacy.As a proof of concept,a quaternary ammonium salt-based pH indicator was developed,berberrubine(BRB),enhancing the action of the anticancer drug hydroxycamptothecin(HCPT)in resistant cells.BRB-induced alkalinization increased lysosomal pH and deactivated lysosomal activity,enabling HCPT to bypass protonation constraints.This enhancement markedly improved the anticancer efficacy of HCPT in resistant cells,providing an innovative approach to address drug resistance and advancing therapeutic technologies.
文摘Corex is an alternative ironmaking process and raceway is one of the important areas to maintain the stability of the furnace. The raceway parameters are well established for blast furnace operation. But for Corex process,it has not yet been established and optimized. Thus,a mathematical model was developed to determine various raceway parameters such as RAFT （raceway adiabatic flame temperature）,tuyere gas velocity and kinetic energy. The model provides an idea about the raceway geometry,zone temperature and kinetic energy accumulated in tuyere gas. Besides,all the raceway parameters have been analyzed to find out their effects on the Corex process. It is found that RAFT influences the gasification reaction kinetics and higher RAFT generates more CO in reduction gas,which improves the metallisation degree of the DRI in shaft. It is also found that increased gas velocity and kinetic energy generate more fines and demand more coke to maintain char bed permeability. High coke rate increases the production cost and lowers the production of hot metal.
基金supported by the Shenzhen Government’s Plan of Science and Technology(JCYJ20190808121407676 and 20200813142301001)National Natural Science Foundation of China(22178223 and 22262010)+1 种基金Guangxi Science and Technology Fund for Distinguished High-Talent Introduction Program(No.RZ2200002233AC22035091).
文摘Rechargeable zinc-air batteries(ZABs)are a promising energy conversion device,which rely critically on electrocatalysts to accelerate their rate-determining reactions such as oxygen reduction(ORR)and oxygen evolution reactions(OER).Herein,we fabricate a range of bifunctional M-N-C(metal-nitrogen-carbon)catalysts containing M-Nx coordination sites and M/MxC nanoparticles(M=Co,Fe,and Cu)using a new class ofγ-cyclodextrin(CD)based metal-organic framework as the precursor.With the two types of active sites interacting with each other in the catalysts,the obtained Fe@C-FeNC and Co@C-CoNC display superior alkaline ORR activity in terms of low half-wave(E1/2)potential(~0.917 and 0.906 V,respectively),which are higher than Cu@C-CuNC(~0.829 V)and the commercial Pt/C(~0.861 V).As a bifunctional electrocatalyst,the Co@C-CoNC exhibits the best performance,showing a bifunctional ORR/OER overpotential(ΔE)of~0.732 V,which is much lower than that of Fe@C-FeNC(~0.831 V)and Cu@C-CuNC(~1.411 V),as well as most of the robust bifunctional electrocatalysts reported to date.Synchrotron X-ray absorption spectroscopy and density functional theory simulations reveal that the strong electronic correlation between metallic Co nanoparticles and the atomic Co-N4 sites in the Co@C-CoNC catalyst can increase the d-electron density near the Fermi level and thus effectively optimize the adsorption/desorption of intermediates in ORR/OER,resulting in an enhanced bifunctional electrocatalytic performance.The Co@C-CoNC-based rechargeable ZAB exhibited a maximum power density of 162.80 mW cm^(−2) at 270.30 mA cm^(−2),higher than the combination of commercial Pt/C+RuO2(~158.90 mW cm^(−2) at 265.80 mA cm^(−2))catalysts.During the galvanostatic discharge at 10 mA cm^(−2),the ZAB delivered an almost stable discharge voltage of 1.2 V for~140 h,signifying the virtue of excellent bifunctional ORR/OER electrocatalytic activity.
基金supported by National Key Research and Development Program of China (2020YFC0844800)the Science and Technology Planning Project of Beijing (Z201100007520006)
文摘The coronavirus disease 2019(COVID-19)pandemic has caused a surge in demand for face masks,with the massive consumption of masks leading to an increase in resource-related and environmental con-cerns.In this work,we fabricated meltblown polypropylene(mb-PP)-based high-performance planar face masks and investigated the effects of six commonly used disinfection methods and various mask-wearing periods on the reusability of these masks.The results show that,after three cycles of treatment using hot water at 70℃ for 30 min,which is one of the most scalable,user-friendly methods for viral disinfection,the particle filtration efficiency(PFE)of the mask remained almost unchanged.After mask wearing for 24 h and subsequent disinfection using the same treatment procedures,the PFE decreased to 91.3%;the average number of bacterial and fungal colonies was assessed to be 9.2 and 51.6 colony-forming units per gram(CFU∙g^(-1)),respectively;and coliform and pyogenic bacteria were not detected.Both the PFE and the microbial indicators are well above the standard for reusable masks after disinfection.Schlieren pho-tography was then used to assess the capabilities of used and disinfected masks during use;it showed that the masks exhibit a high performance in suppressing the spread of breathed air.
基金financially supported by the National Natural Science Foundation of China (NSFC,No.21805024)Science Foundation of China University of Petroleum (Nos. 2462019QNXZ02,2462018BJC004)+1 种基金the Scientifc and Technological Research Program of Chongqing Municipal Education Commission (No.KJ QN202001335)the Research Program ofYongchuan Science and Technology Commission (Ycstc,No.2018nb1402)。
文摘Long-emission carbon dots(CDs) is triggering immense enthusiasm on account of their intrinsic merits of high chemical stability and excellent optical properties.In this study,a facile and rapid approach was developed for the preparation of barium-doped carbon dots(Ba-CDs) with yellow fluo rescence emission and high quantum yields.Surface chemistry and the chemical architecture of the Ba-CDs was revealed under various spectroscopic methods.This work provides more insights into the effects of charge transfer caused by Ba heteroatoms,which is considered as the most challenging step in the investigation on luminescence mechanism.Remarkably,the prepared Ba-CDs were successfully applied as fluorescent probes in the detection of trace water in organic solvents(ethanol,isopropanol,acetone,tetrahydrofuran).Comparing with traditional fluorescent probes for water detection in organic solvents,Ba-CDs detection provides a more sensitive,much faster and more economical approach.
基金supported by the National Natural Science Foundation of China under Grant Nos.81873915,61702225 and 61806026Ministry of Science and Technology Key Research and Development Program of China under Grant No.2018YFC0116902+3 种基金by the Natural Science Foundation of Jiangsu Province under Grant No.BK20180956by the 2018 Six Talent Peaks Project of Jiangsu Province under Grant No.XYDXX-127by the Science and Technology demonstration project of social development of Wuxi under Grant WX18IVJN002by the Philosophy and Social Science Foundation of Jiangsu Province(18YSC009).
文摘With the rapid development of the Internet,the amount of data recorded on the Internet has increased dramatically.It is becoming more and more urgent to effectively obtain the specific information we need from the vast ocean of data.In this study,we propose a novel collaborative filtering algorithm for generating recommendations in e-commerce.This study has two main innovations.First,we propose a mechanismthat embeds temporal behavior information to find a neighbor set in which each neighbor has a very significant impact on the current user or item.Second,we propose a novel collaborative filtering algorithm by injecting the neighbor set into probability matrix factorization.We compared the proposed method with several state-of-the-art alternatives on real datasets.The experimental results show that our proposed method outperforms the prevailing approaches.
文摘The precise determination of zona pellucida (ZP) hardness is largely unknown due to the lack of appropriate measuring and modelling methods. In this study, we have used experimental and theoretical models to describe the mechanical behavior of a single oocyte cell to improve the assisted reproductive technology (ART) outcomes by assessing oocyte/embryo quality. This paper presents the development of: i) a microinjection model to estimate the force of ZP penetration, ii) a micropipette aspiration model to determine the corresponding hardness, and iii) an experimental procedure to generate the required data for these two models. Our results show that the estimated penetration force provides a performance target for the penetration process during intracytoplasmic sperm injection (ICSI), while the estimated corresponding hardness serves as an indicator of the extent of deformation sustained by the oocyte prior to penetration. Evaluation of these results shows that a routine assessment of ZP hardness under microinjection would allow for the identification of certain oocyte pools for which further manipulation is recommended in order to improve injection, hatching and finally ART outcomes.
基金Supported by the National Science and Technology Support Projects Funded by Ministry of Science & Technology of China (No. 2006BAK07B04)
文摘In this paper, a high-performance and low-complexity luminance transient improvement （LTI） algorithm is proposed and efficiently implemented on field programmable gate army （FPGA） devices, which can be widely used to enhance the sharpness of digital video. The proposed algorithm generates the cor- rection signal by using the difference of the outputs of two Gaussian filters with different variances, and then modulates the correction signal adaptively according to the local contrast information of video frames. A 2-D min/max nonlinear filter is employed to suppress overshoots around edges. The proposed algorithm is thoroughly confirmed by experiments and compared with other algorithms on irrkages, which produces steeper edges and better visual quality while suppressing noise and artifacts. And the hardware architecture suitable for FPGA implementation is optimized based on the property of the algorithm and proves to be effective and efficient in many respects, such as resource consumption, performance and reconfigura- bility. The specific implementation details on both Xilinx and Ahera FPGA devices are also described in this paper.
文摘This paper describes an approach to identify epicyclic and tricyclic motion during projectile flight caused by mass asymmetries in spinstabilized projectiles. Flight video was captured following projectile launch of several M110A2E1 155 mm artillery projectiles. These videos were then analyzed using the automated flight video analysis method to attain their initial position and orientation histories.Examination of the pitch and yaw histories clearly indicates that in addition to epicyclic motion's nutation and precession oscillations, an even faster wobble amplitude is present during each spin revolution, even though some of the amplitudes of the oscillation are smaller than 0.02 degree.The results are compared to a sequence of shots where little appreciable mass asymmetries were present, and only nutation and precession frequencies are predominantly apparent in the motion history results. Magnitudes of the wobble motion are estimated and compared to product of inertia measurements of the asymmetric projectiles.
